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The Bugbear Of Indigenous Commercial Fishing Rights On The Eastern Frontiers Of Australia And The United States, Teresa Singh Jan 2025

The Bugbear Of Indigenous Commercial Fishing Rights On The Eastern Frontiers Of Australia And The United States, Teresa Singh

LL.M. Essays & Theses

Restrictions on the commercial exercise of Indigenous fishing rights are plentiful across the U.S. and Australia. They have particular force and prevalence for Indigenous communities residing in the sites of the first colonies in both nations. This note exposes the common history underlying the diminished rights in these regions and argues the situation amounts to a critical environmental injustice. It follows that environmental justice advocates and scholars should embrace and advance the more encompassing iteration of Indigenous fishing rights urged by this note and support their restoration as a form of corrective justice for these communities.


Principles Of Biomedical Research, Faina Linkov, Matthew C. Kostek Jan 2025

Principles Of Biomedical Research, Faina Linkov, Matthew C. Kostek

Open Education Materials

HLT 430/530

CC BY-NC-SA


Occupied Lands, Occupied Histories: Activist-Historians And The Red Power Movement, Elena Rose Paz Thompson Jan 2025

Occupied Lands, Occupied Histories: Activist-Historians And The Red Power Movement, Elena Rose Paz Thompson

History - Master of Arts in Teaching

I. Synthesis Essay.............................4

II. Primary Document Collection......25

III. Textbook Critique........................37

IV. New Textbook Writing.................42


Examining The Psychometric Properties Of The Classroom Whiteness Scale (Claws) Through Rasch Partial Credit Analysis, Jaylene T. Patterson Jan 2025

Examining The Psychometric Properties Of The Classroom Whiteness Scale (Claws) Through Rasch Partial Credit Analysis, Jaylene T. Patterson

Theses and Dissertations--Educational, School, and Counseling Psychology

This pilot study examines how whiteness manifests in K-12 classrooms by developing and evaluating the Classroom Whiteness Scale (ClaWS), an instrument designed to assess in-service teachers’ salience and engagement with whiteness-informed practices. ClaWS consists of 21 items across two subscales: one measuring the salience of whiteness-related beliefs in teachers’ pedagogical decisions and the other capturing the frequency of these practices in classroom settings. Rooted in critical whiteness studies, the scale operationalizes key dimensions of whiteness, including ethnocentric monoculturalism, white standardization, white silence, right to comfort, white saviorism, and colorblind racial ideology.

Using Rasch Partial Credit Model (RPCM) analysis, this study …


Generative Contracts, Spencer Williams Jan 2025

Generative Contracts, Spencer Williams

Faculty Scholarship

This Article examines how consumers can use generative artificial intelligence to write their own contracts. Popularized by “chatbots” such as OpenAI’s ChatGPT, generative AI is a form of artificial intelligence that uses statistical models trained on massive amounts of data to generate human-like content such as text, images, music, and more. Generative AI is already being integrated into the practice of law and the legal profession. In the context of contracting and transactional law, most generative AI tools are focused on reviewing and managing large volumes of business contracts. Thus far, little attention has been given to using generative AI …


Artificial Intelligence And The Self-Represented Inventor, Brenda M. Simon Jan 2025

Artificial Intelligence And The Self-Represented Inventor, Brenda M. Simon

Faculty Scholarship

Lack of access to competent legal representation is pervasive throughout the justice system. Unfortunately, the patent system is no exception. Self-represented inventors are far less likely to obtain patents than those with legal representation. Increasing access to artificial intelligence (AI) can mitigate some of the disadvantages of self-representation, but the use of AI will also raise new challenges. To the extent that AI systems can help self-represented inventors, they can begin to address one of the underlying causes of the patent gap—lack of access to high quality legal services. Women and people of color hold fewer patents, in part, because …


Ending The Paper Chase At The U.S. Supreme Court, William J. Aceves Jan 2025

Ending The Paper Chase At The U.S. Supreme Court, William J. Aceves

Faculty Scholarship

This Article offers the first systematic analysis of the administrative impact and practical consequences of the U.S. Supreme Court's filing requirements. The lack of meaningful research on this subject reveals how Justices, clerks, and lawyers have become inured to these requirements and their attendant costs.

Every year, the Supreme Court receives approximately five thousand petitions for certiorari. With some exceptions, the Court compels litigants to file multiple paper copies of their submissions. When combined, these submissions exceed two hundred thousand documents, which include over five million separate pieces of paper. If stacked, these documents would reach beyond the height of …


Beyond Involuntary Movements: A Case Of Diabetic Striatopathy Complicated By Cardiac Arrest, Deepa M Jan 2025

Beyond Involuntary Movements: A Case Of Diabetic Striatopathy Complicated By Cardiac Arrest, Deepa M

Manipal Journal of Nursing and Health Sciences

Abstract

Diabetic striatopathy (DS) is a rare neurological manifestation of poorly controlled diabetes mellitus, typically characterized by hemichorea–hemiballismus and distinctive basal ganglia abnormalities on neuroimaging. We report the case of a 57-year-old woman with type 2 diabetes mellitus who presented with generalized choreiform and ballistic movements and subsequently developed an in-hospital cardiac arrest. Diagnostic evaluation revealed uncontrolled hyperglycemia (random blood glucose 243 mg/dL; HbA1c 8.3%) without ketosis, with neuroimaging findings consistent with DS. The patient was initially managed in the casualty department and subsequently admitted to a neuro stepdown intensive care unit, where she remained for 10 days. Comprehensive medical, …


Effects Of Starter Cultures On The Metabolite Profile, Antioxidant Activities, And Anti-Aging Properties Of Tapuy Lees, Edward Kevin B. Bragais, Paul Mark B. Medina Jan 2025

Effects Of Starter Cultures On The Metabolite Profile, Antioxidant Activities, And Anti-Aging Properties Of Tapuy Lees, Edward Kevin B. Bragais, Paul Mark B. Medina

Biology Faculty Publications

The Philippine rice wine (tapuy) and tapuy lees making process utilizes bubod, the traditional starter culture. The bubod contains variable number and species of microorganisms and influences the physical and chemical properties of tapuy and tapuy lees, resulting in inconsistent quality products. Hence, improvement and standardization of local starter culture are significant. Here, we examined the effects of well-defined starter cultures (Rhizopus oryzae (RO), Mucor indicus (MI), and Saccharomyces cerevisiae (SC)) and bubod on the metabolite profile, antioxidant, and anti-aging activities of tapuy lees. Our results showed the presence of polyphenols (102.36 ± 2.84 to 173.92 …


A Concoction Pipeline For Generating Molecular Operational Taxonomic Units (Motus) Among Riparian And Aquatic Beetles, Emmanuel D. Delocado, Voltaire Rafael H. Banzon, Enrico Gerard S. Sanchez Jan 2025

A Concoction Pipeline For Generating Molecular Operational Taxonomic Units (Motus) Among Riparian And Aquatic Beetles, Emmanuel D. Delocado, Voltaire Rafael H. Banzon, Enrico Gerard S. Sanchez

Biology Faculty Publications

No abstract provided.


Assessment Of Validity And Reliability Of Survey Tool For Good Aquaculture Practices Of Philippine Shellfish Farmers, Crisanto M. Lopez, A. Rustia, E. Barrios, D. Tanay Jan 2025

Assessment Of Validity And Reliability Of Survey Tool For Good Aquaculture Practices Of Philippine Shellfish Farmers, Crisanto M. Lopez, A. Rustia, E. Barrios, D. Tanay

Biology Faculty Publications

Food safety farm-to-fork model compliance to good aquaculture practices (GAqP) of Filipino shellfish farmers placed a special consideration in the validation and reliability of the developed survey tool that consisted of 11 sections of GAqP provisions based on Philippine National Standards 207:2017 and CXS 52-2003 standards. Validation [content validity index (CVI) and impact factor (IF)] and reliability (Cronbach’s alpha) included pre-testing (item difficulty and discrimination index) (n = 7 shellfish farmers; n = 7 technical personnel on fisheries), validation (n = 30 shellfish farmers and five experts), and pilot testing (n = 30 shellfish farmers) to measure the reliability. Pre-testing …


Evaluation Of A Customer Development Simulator Using Large Language Model-Based Multi-Agent System And Synthetic Respondents, Lois Abigail To, Zachary Matthew C. Alabastro, Joseph Benjamin R. Ilagan Jan 2025

Evaluation Of A Customer Development Simulator Using Large Language Model-Based Multi-Agent System And Synthetic Respondents, Lois Abigail To, Zachary Matthew C. Alabastro, Joseph Benjamin R. Ilagan

Quantitative Methods and Information Technology Faculty Publications

Customer development (CD) is a Lean Startup (LS) methodology for startups to validate their business hypotheses and refine their business model based on customer feedback. This paper proposes designing a large language model-based multi-agent system (LLM MAS) to enhance the customer development process by simulating customer feedback. Using LLMs’ natural language understanding (NLU) and synthetic multi-agent capabilities, startups can conduct faster validation while obtaining preliminary insights that may help refine their business model before engaging with the real market. The study presents a model in which the LLM MAS simulates customer discovery interactions between a startup founder and potential customers, …


Millennials And Generation Z Customers' Service Recovery Evaluation From A Self-Esteem Perspective, Megan Mcdade Jan 2025

Millennials And Generation Z Customers' Service Recovery Evaluation From A Self-Esteem Perspective, Megan Mcdade

Graduate Thesis and Dissertation post-2024

While a significant amount of research has been conducted to assess the effectiveness of service recovery based on various factors, there is limited research on emerging customer segments, specifically Generation Z and Millennials. Justice theory has been predominant in service recovery literature, however, recent studies suggest that self-esteem can provide valuable insight into understanding customers’ evaluations of service recovery. This research focuses on how Generation Z and Millennial customers evaluate service recovery efforts in the context of restaurants. The main objective of this study is to examine how these customers perceive economic (compensation) and psychological (apology) service recovery strategies, considering …


Understanding The Mechanism In Shaping Guest Acceptance Of Service Robots In Caribbean Hotels: The Moderating Role Of Cultural Familiarity In The Cac Model, Jamilia A. Lawrence Jan 2025

Understanding The Mechanism In Shaping Guest Acceptance Of Service Robots In Caribbean Hotels: The Moderating Role Of Cultural Familiarity In The Cac Model, Jamilia A. Lawrence

Graduate Thesis and Dissertation post-2024

Service robots continue to become increasingly popular in the hospitality and tourism industry. Understanding the cognitive and emotional processes is important in explaining the sequential processes of guests accepting new technologies. Especially in regions like the Caribbean, where human-to-human interaction and personalized services are highly valued.

This study investigates how cognitive evaluations of service robots, including utility, coolness, autonomy, courtesy, and interactivity, influence guests' emotional responses and their acceptance of the technology in Caribbean hotels. Additionally, the study explores the moderating role of cultural familiarity in the relationship between emotion and acceptance.

Using the cognitive-affective-conative (CAC) model, 415 responses were …


Comparing Inter-Rater Reliability For Two Coding Methodologies In Meta-Analysis Data Extraction, Christine D. Destefano Jan 2025

Comparing Inter-Rater Reliability For Two Coding Methodologies In Meta-Analysis Data Extraction, Christine D. Destefano

Graduate Thesis and Dissertation post-2024

Meta-analyses are critical tools for evidence-based policymaking, but their validity depends heavily on accurate data extraction from primary studies. While previous research has focused on procedural aspects of coding and reliability of effect size extraction, there remains a significant gap in understanding how to improve inter-rater reliability (IRR) for moderator variables that provide crucial context for meta-analytic findings. This study compared two methodological approaches for coding moderator variables: traditional low-inference coding and a novel drill-down questioning technique adapted from database development principles. Using a comparative analysis design, two independent coders extracted data from 18 primary studies included in a published …


Enhancing The Accuracy Of Image Classification For Degenerative Brain Diseases With Cnn Ensemble Models Using Mel-Spectrograms, Sang-Ha Sung, Michael Pokojovy, Do-Young Kang, Woo-Yong Bae, Yeon-Jae Hong, Sangjin Kim Jan 2025

Enhancing The Accuracy Of Image Classification For Degenerative Brain Diseases With Cnn Ensemble Models Using Mel-Spectrograms, Sang-Ha Sung, Michael Pokojovy, Do-Young Kang, Woo-Yong Bae, Yeon-Jae Hong, Sangjin Kim

Mathematics & Statistics Faculty Publications

Alzheimer’s disease (AD) and Parkinson’s disease (PD) are prevalent neurodegenerative disorders among the elderly, leading to cognitive decline and motor impairments. As the population ages, the prevalence of these neurodegenerative disorders is increasing, providing motivation for active research in this area. However, most studies are conducted using brain imaging, with relatively few studies utilizing voice data. Using voice data offers advantages in accessibility compared to brain imaging analysis. This study introduces a novel ensemble-based classification model that utilizes Mel spectrograms and Convolutional Neural Networks (CNNs) to distinguish between healthy individuals (NM), AD, and PD patients. A total of 700 voice …


Covariate Selection For Rna-Seq Differential Expression Analysis With Hidden Factor Adjustment, Farzana Noorzahan, Hyeongseon Jeon, Yet Nguyen Jan 2025

Covariate Selection For Rna-Seq Differential Expression Analysis With Hidden Factor Adjustment, Farzana Noorzahan, Hyeongseon Jeon, Yet Nguyen

Mathematics & Statistics Faculty Publications

In RNA-seq data analysis, a primary objective is the identification of differentially expressed genes, which are genes that exhibit varying expression levels across different conditions of interest. It is widely known that hidden factors, such as batch effects, can substantially influence the differential expression analysis. Furthermore, apart from the primary factor of interest and unforeseen artifacts, an RNA-seq experiment typically contains multiple measured covariates, some of which may significantly affect gene expression levels, while others may not. Existing methods either address the covariate selection or the unknown artifacts separately. In this study, we investigate two integrated strategies, FSR_sva and SVAall_FSR, …


Characterizing Conditioned Pain Modulation And Quadriceps Motor Unit Recruitment Among Older Adults With Chronic Knee Pain, Emily J. Parsowith Jan 2025

Characterizing Conditioned Pain Modulation And Quadriceps Motor Unit Recruitment Among Older Adults With Chronic Knee Pain, Emily J. Parsowith

Graduate Thesis and Dissertation post-2024

BACKGROUND: Over 25% of U.S. older adults experience chronic knee pain, which worsens with inactivity, creating a cycle of pain, disability, and sedentary behavior. However, a limited understanding of its underlying mechanisms hinders the development of effective treatments. PURPOSE: This study integrated assessments of Conditioned Pain Modulation (CPM) and motor unit control to elucidate the role of pain sensitization and neuromuscular impairments specific to chronic knee pain. METHODS: Seventy-five participants were divided into three groups: young adults (n=25), older adults without pain (n=30), and older adults with chronic pain (n=20). CPM efficiency was evaluated using heat and pressure test stimuli …


Understanding Pre-Service Teachers’ Engagement, Application And Perception Of Instructor Feedback In An Online Teacher Education Course: An Action Research Study, Iram Khan Jan 2025

Understanding Pre-Service Teachers’ Engagement, Application And Perception Of Instructor Feedback In An Online Teacher Education Course: An Action Research Study, Iram Khan

Graduate Thesis and Dissertation post-2024

Teachers should prioritize continuous professional development through shared experiences and reflective teaching to remain competitive in the global education system and become better teachers to assist language learners in achieving their goals (Vadivel et al., 2021). Professional development courses are crucial for enhancing teaching skills; however, there is a concern that such initiatives seem ineffective in promoting change in teaching practices (Darling-Hammond et al., 2017; Gore et al., 2017). Implementing effective instructional approaches in teacher education courses, such as feedback and reflection, is crucial for aspiring teachers to enhance their knowledge and professional growth (Darling-Hammond et al., 2017; Pharis et …


Florida Title I School Principals' Characteristics And Practices In Professional Learning As Related To Student Reading Achievement, Sarah K. Hall Jan 2025

Florida Title I School Principals' Characteristics And Practices In Professional Learning As Related To Student Reading Achievement, Sarah K. Hall

Graduate Thesis and Dissertation post-2024

This study explored the relation between Florida’s Title I elementary school principals’ characteristics and how they design professional learning with student reading achievement. This study used Descriptive Statistics, Spearman’s Correlation, Independent Samples T-tests, Pearson’s Correlation, and ANCOVA to explore the relation between 259 of Florida’s Title I public elementary school principals’ characteristics (years of experience, number of state reading certifications, degrees, and level of autonomy) and how they design professional learning with student reading achievement. The research design was quantitative and correlational. Data was collected from 58 districts through a piloted survey using parametric sampling. A statistically significant difference was …


Developing, Designing, And Evaluating Knightly Codes: A System Of Resources Supporting Motivation Using Automated Feedback, Kyle S. Dencker Jan 2025

Developing, Designing, And Evaluating Knightly Codes: A System Of Resources Supporting Motivation Using Automated Feedback, Kyle S. Dencker

Graduate Thesis and Dissertation post-2024

Providing meaningful practice and feedback is a critical component of supporting students' learning, but it is also labor-intensive and time-consuming for instructors. This study evaluated the effectiveness of Knightly Codes, a supplemental system designed to provide automated, tiered feedback to students in an introductory, college-level Computer Science course designed to help them develop strategies to tackle real-world coding problems and maintain or improve their interest and motivation. Key design features include increasingly specific guidance as students submit multiple incorrect solutions, gamification elements including progress checks, badges, and personal and global statistics, and reflection surveys to promote self-regulated learning. A total …


Comparing Experiences In Medication-Assisted Recovery Anonymous (Mara) Versus 12-Step Groups: A Qualitative Study, Rachel Totaram Jan 2025

Comparing Experiences In Medication-Assisted Recovery Anonymous (Mara) Versus 12-Step Groups: A Qualitative Study, Rachel Totaram

Graduate Thesis and Dissertation post-2024

The United States continues to face an opioid epidemic, with over 80,000 opioid overdose deaths reported in 2023. Although medications for opioid use disorder (MOUDs) are effective treatments for opioid use disorder (OUD), stigma remains a major barrier to their adoption. People taking MOUDs often feel stigmatized within traditional 12-step peer support groups like Alcoholics Anonymous or Narcotics Anonymous (AA/NA), potentially harming the recovery process. Medication-Assisted Recovery Anonymous (MARA) was recently developed as an alternative 12-step support group explicitly open to people using MOUD.

This qualitative mixed methods study retrospectively examines how MARA meetings differ from AA/NA meetings, based on …


Teacher Retention And The Disabilities-To-Prison Pipeline, Angela P. Mccloud-Bond Jan 2025

Teacher Retention And The Disabilities-To-Prison Pipeline, Angela P. Mccloud-Bond

Graduate Thesis and Dissertation post-2024

There is an overrepresentation of individuals with disabilities in the criminal and juvenile justice systems. Similar to the commonly known School-to-Prison Pipeline, Christoper Mallet has coined the term the Disabilities-to-Prison Pipeline to refer to this growing problem. Research has not yet determined how individual variables at the school or district levels lead to the expansion of the Disabilities-to-Prison Pipeline. Mallot (2021) presented three possible hypotheses to explain the expansion of this phenomenon: the differential treatment hypothesis, the school failure hypothesis, and the susceptibility hypothesis. There is a significant gap in the literature that focuses specifically on the differential treatment of …


The Effect Of Four Vocabulary Tasks On The Initial Learning And Retention Of Formulaic Language: The Case Of Phrasal Verbs, Eman Barri Jan 2025

The Effect Of Four Vocabulary Tasks On The Initial Learning And Retention Of Formulaic Language: The Case Of Phrasal Verbs, Eman Barri

Graduate Thesis and Dissertation post-2024

The quasi-experimental study investigated the effect of four vocabulary tasks on the learning and retention of English phrasal verbs (PVs). University Intensive English Program students (91) completed one of the following tasks: One Fill-in-the-Blank, Three Fill-in-the-Blank, Sentence Writing, and Composition Writing. Their knowledge of eight target PVs was measured using a modified vocabulary knowledge scale at three points: pretest, immediate posttest, and delayed posttest (two weeks later). A mixed factorial ANOVA revealed a significant interaction between task and time. Follow-up repeated-measures and one-way ANOVAs showed that the Three Fill-in-the-Blank produced the highest scores on both posttests. Consistent with findings on …


Examining The Impact African American Male Teachers Have On The Math Scores Of Underserved Students, Demetrice Thomas Jan 2025

Examining The Impact African American Male Teachers Have On The Math Scores Of Underserved Students, Demetrice Thomas

Graduate Thesis and Dissertation post-2024

This study contributed to a growing body of evidence emphasizing that teacher identity profoundly influences not only how students learn but also how they perceive themselves and their potential. As Gershenson (2022) noted, “Black teachers provide benefits to all students, fostering higher achievement and stronger aspirations,” highlighting the essential role of diverse educators in shaping student success. Consistent academic gains observed among students taught by African American male teachers reinforce the urgent need for educational systems to prioritize equity not only in student outcomes but also in diversifying the teaching workforce. Despite African American male teachers comprising less than 2% …


Queering The Queer Bildungsroman: Literature Of Aids, The Rhizome, And Rat Bohemia, Emma Tolliver Jan 2025

Queering The Queer Bildungsroman: Literature Of Aids, The Rhizome, And Rat Bohemia, Emma Tolliver

Graduate Thesis and Dissertation post-2024

The advent of the bildungsroman with Johann Wolfgang Von Goethe’s Wilhelm Meister’s Apprenticeship was a seminal moment in literature. From that point onward, the genre, which would come to be known as the “coming-of-age” novel, evolved and as such developed a variety of subgenres. This thesis focuses on the queer bildungsroman, a subgenre which has been dubbed the “coming-out” novel. Through Judith Butler’s work, I conceptualize genre as gender. Additionally, I utilize the Deleuzian concepts of the rhizome, becoming, and minor literature along with literature of AIDS to argue that the queer bildungsroman is not solely the coming out novel. …


Cigarettes, Flesh, & Other Cravings, Gabrielle F. Decker Jan 2025

Cigarettes, Flesh, & Other Cravings, Gabrielle F. Decker

Graduate Thesis and Dissertation post-2024

Cigarettes, Flesh, & Other Cravings is a collection of short stories that explores themes of motherhood, death, and desire. Each character struggles with the friction between society's expectations and their desires for happiness, all through the lens of the surreal and the absurd. A destructive raccoon’s nightly visits unravel a woman’s sense of control. A teenager begins an internship with a conspiracy-obsessed clown. A minuscule old woman tumbles out of a chicken egg. A fissure in a kitchen floor births an imp. A Choose Your Own Adventure examines the illusion of choice. In Hell, torture is personalized. Cigarettes, Flesh, & …


Methods And Applications Of Coherent Analog Photonic Processing, Andrew B. Klein Jan 2025

Methods And Applications Of Coherent Analog Photonic Processing, Andrew B. Klein

Graduate Thesis and Dissertation post-2024

Photonic processing is a compelling approach to address the increasing computational requirements of neural networks, promising increased processing speed and better energy efficiency for operations such as matrix-vector multiplication. However, in practice the limitations of photonic hardware necessitate that these systems adopt fixed-point encoding rather than the floating-point standard used by digital electronics. The reduction in accuracy incurred by this requirement must be managed and addressed for real world applications. In this work, we present a reconfigurable, scalable, and parallelizable photonic multiplier cell using coherent balanced photodetection of analog signals to produce signed multiplications. This style of system outperforms other …


High-Efficiency Micro-Display Light Engines, Yizhou Qian Jan 2025

High-Efficiency Micro-Display Light Engines, Yizhou Qian

Graduate Thesis and Dissertation post-2024

Augmented reality displays, which integrate digital information with environmental backgrounds, are emerging in our daily lives. To ensure readability under outdoor environments with intense ambient light, AR displays must achieve high luminance levels suitable for human visual perception. However, severe light leakage in waveguide couplers and significant losses during exit pupil expansion limit the overall system efficiency to approximately 4%, requiring the light engine to reach luminance levels over one million nits. In addition, to match visual acuity while keeping a compact light engine size (< 1cc), full-color pixel pitch must be below 4 µm. This dissertation is devoted to addressing the possibility of existing light engines to meet these demanding requirements.

In Chapter 2, we comprehensively analyze the power consumption of existing commercial light engines …


Molecular Basis For The Disaggregase Activity Of Protein Disulfide Isomerase, Antonio Mele Jan 2025

Molecular Basis For The Disaggregase Activity Of Protein Disulfide Isomerase, Antonio Mele

Graduate Thesis and Dissertation post-2024

Protein disulfide isomerase (PDI) is an essential, multifunctional, and promiscuous protein with a modular abb’xa’c domain arrangement. Conformational flexibility and the independent, yet coordinated, functionality of PDI domains facilitate protein folding, redox regulation, and the maintenance of cellular homeostasis. Previous investigations have shown that PDI can inhibit amyloid β peptide aggregation, associated with Alzheimer's disease, and is required for cholera toxin disassembly, the rate-limiting step in Vibrio cholerae pathogenesis. However, the precise mechanistic details underlying these interactions remain to be elucidated. Using molecular and biophysical approaches, this study has begun to establish substrate-induced unfolding, or conditional disorder, of PDI as …