Digital Commons Network^™

Association Between Neighborhood-Level Social Vulnerability And Hypertension Outcomes, John E. Brush Jr., Chungsoo Kim, Yuntian Liu, Xin Xin, Chenxi Huang, Iris J. Lundy, Jordan R. Asher, Mitsuaki Sawano, Patrick Young, Jacob Mcpadden, Mark Anderson, John S. Burrows, Harlan M. Krumholz, Yuan Lu

Department of Medicine Faculty Publications

Background

Neighborhood-level social vulnerability is associated with hypertension prevalence and severity and with cardiovascular complications in conditions other than hypertension, but its association with cardiovascular complications in patients with hypertension is understudied.

Objectives

The aim of the study was to examine how the neighborhood-level social vulnerability index (SVI) influences cardiovascular outcomes in a large, diverse cohort of patients with hypertension.

Methods

We used electronic health data to examine the association between census tract-level rankings for the SVI with a composite endpoint of incident myocardial infarction, congestive heart failure, or stroke.

Results

In a longitudinal cohort of 330,972 patients with hypertension …

Project Manager Risk Response Via The Schedule Duration Mechanism In New Product Development, James S. Bryant

Open Access Dissertations

This experimental study investigated the relationship between project risk level and forecasted project schedule duration. Grounded within a systematic literature review, the research is motivated by the continuing high failure rate for new product development (NPD) projects to meet their time objectives. U.S.-based project managers (PMs) were given a project network diagram, assigned to one of four experimental groups (each group also receiving varying information regarding project risks), and asked to forecast the most likely schedule duration from start to finish. The data suggest that there is no correlation between the level of project risk and the forecasted duration and …

Incentives, Performance Metrics, And Healthcare Supply Chain Waste, Sharon Ann Franzetta

Open Access Dissertations

Healthcare spending in the United States (US) is increasing at a rate higher than the US gross domestic product while the demand for healthcare services is simultaneously increasing. With supply costs posing as the second highest cost in hospital expenditures, reducing supply expenses by means of eliminating supply management waste could potentially reduce overall healthcare costs. Supported by evidence found through three manuscript studies, this study expounds upon the findings from previous studies to better understand the relationship between medical supply inefficiency due to the influence of stakeholders’ misaligned decision-making in efforts to achieve performance goals. This exploratory, mixed-methods study …

Monotonic Constant Normal Stiffness Tests For Improving The Skin Friction Resistance Prediction Of Drilled Piles In Sand, Amir Babaee

Open Access Dissertations

This body of work consists of three manuscripts. The first manuscript focuses on the evaluation of constant normal stiffness tests on sand using a newly developed active control system. The second manuscript is related to prediction of axial capacity of drilled and grouted micropiles for offshore foundations. The third manuscript corresponds to evaluation of quality control measures for cyclic resistance of sand using cyclic direct simple shear equipment.

Small diameter drilled piles (micropiles) are being considered for use as an economical foundation for floating offshore wind structures. On land, micropiles are typically load tested to confirm design capacity; this is …

Machine Learning For Optimized Ocean Exploration Data Analysis, Puja Banerjee

Open Access Dissertations

The deep sea remains one of the most crucial frontiers in Earth sciences, with vast unknowns regarding its biodiversity, ecosystem dynamics, and geological features and processes, and impact and interaction with humans. Ocean exploration seeks to address this gap by focusing data collection in some of the least known places on the planet in order to significantly expand our knowledge of marine ecosystems, geological formations, and oceanographic processes. Ocean exploration datasets provide crucial insights into a wide range of scientific domains including: deep sea biodiversity, seafloor morphology, and deep-sea soundscapes. The advent of autonomous and remotely operated underwater vehicles (AUVs …

Development And Deployment Of In Situ Fiber Optic Distributed Temperature Sensing Systems And Data Processing Workflows For Oceanographic Observatories In Coastal And Deep-Sea Environments, Johann Sebastian Becker

Open Access Dissertations

Over the last two decades, fiber optic distributed temperature sensing (DTS) has emerged as a transformative technology capable of providing unprecedented spatiotemporal resolution observations of temperature in a broad range of environmental sensing, industrial, and civil engineering monitoring applications. DTS uses a single interrogator unit to measure temperature continuously along an optical fiber, effectively turning the fiber into the equivalent of an array of temperature probes that can be interrogated synoptically. Modern commercially-available DTS systems are capable of continuous sensing with sampling frequencies up 5 sec, spatial resolution of 0.25 m, and temperature precision up to 0.01 °C) observations, on …

The Effect Of Maternal Diet On Developmental Programming: A Cross Species Analysis, Lindsey Eileen Eaton

Open Access Dissertations

Maternal nutrition plays an important role in shaping offspring health through developmental programming, with lasting implications on metabolic function and disease susceptibility. This dissertation explores the molecular and physical consequences of maternal nutrition, particularly its effects on pancreatic development and function in offspring. Chapter one provides a comprehensive review of the literature, detailing the mechanisms of fetal development, epigenetic regulation, and metabolic programming. It highlights the thrifty phenotype hypothesis, the role of DNA methylation and histone modifications, and the impact of maternal nutrition, emphasizing how nutrient availability during pregnancy influences fetal organogenesis and long term metabolic health.

Chapter two examines …

Numerical Modeling Study Of Coastal Impacts From Extreme Storms And Sea Level Rise In Southern New England, Deborah Crowley

Open Access Dissertations

Coastal areas in southern New England are vulnerable to a range of impacts from extreme storms and sea level rise. The most frequent extreme storms are extratropical storms, commonly referred to as nor’easters, named for the direction of the strongest winds, though these storms also have strong winds from other directions.

Storm winds generate large waves and push water up along the coast in the form of storm surge. The combined impacts of increased water levels and waves include flooding and morphological change. Sea level rise (SLR) will exacerbate these processes, amplifying the associated impacts, which may pose increasing threats …

Dynamics Of Metal-Coordinated Coumarin Dyes For Photoswitching Applications, Danielle Jacoby

Open Access Dissertations

Optical transient absorption spectroscopy is a fundamental pump-probe technique that is used to analyze the photophysical and photochemical properties of molecules. Our research group specifically utilizes both a femtosecond and nanosecond set up to probe dynamics of molecules on time scales ranging from 100s of femtoseconds to approximately 50 microseconds. Chapter 2 is a standard operating procedure for the nanosecond transient absorption instrument.

Photoacids are molecules that undergo a change in the acidity of one of their protons when exposed to light. Utilizing this phenomenon, we have designed a series of dyes that, when bound to divalent first row transition …

Electro-Vascular Dynamics During Auditory Processing: Variation Along The Schizotypy Continuum, John P. Mclinden

Open Access Dissertations

Electroencephalography (EEG) and functional near-infrared spectroscopy (fNIRS) are complementary noninvasive neuroimaging modalities that have contributed greatly to our understanding of the mechanisms of auditory processing. As an emerging technology, fNIRS has produced promising insights into the mechanisms of auditory processing, although considerable work remains to characterize hemodynamic responses in auditory tasks. In addition, the complementary nature of EEG and fNIRS and the relationships between the signals they record have been underexplored. In particular, nonlinear interactions between these signals remain under-characterized, despite the potential benefit to future multimodal neuroimaging studies. A challenge in understanding these interactions is the influence of systemic …

Democratizing Deep-Sea Technology Development Using Rapid Prototyping Techniques, Breanna Motsenbocker

Open Access Dissertations

Deep-sea research and exploration have consistently been inaccessible to a broader oceanographic community due to the lack of affordable technology and resources that are required for this type of work. Traditionally, to investigate the deep sea, large research vessels are required to operate the expensive and massive equipment that can withstand the intense pressure and harsh environment beyond 200 meters of water. Not only does this lessen the capacity for exploring the deep sea but it also introduces an extreme inequity for who can participate and lead these efforts. With a growing demand for the global Blue Economy and a …

Light, Symbiosis, And The Biology Of Corals, Taylor R. Lindsay

Open Access Dissertations

Light is critical for the survival of most shallow water scleractinian corals. Corals are mixotrophs, acquiring energy via both feeding on water column plankton and photosynthesis via a symbiotic relationship with dinoflagellates living within their tissues. Corals rely heavily on photosynthetically derived metabolites through this symbiotic relationship, intrinsically linking their biology to light availability. Corals are known to modulate their biology to maximize light capture. However, there is a limited understanding of the interaction between morphology, physiology, and energetic strategy, as well as how light may affect these relationships. In Chapter 1, we quantified the morphology, physiology and energetic …

Development Of A Scituate Reservoir Mitigation Model For Assessing Flood Control During Extreme Scenarios, Supria Paul

Open Access Dissertations

Effective reservoir management is essential for mitigating downstream flooding, especially with the increasing frequency and intensity of extreme weather events impacting major drinking water reservoirs such as the Scituate Reservoir in Rhode Island. These reservoirs provide water for large populations but can be overwhelmed by intense precipitation, flooding and land cover changes. Climate change is expected to increase precipitation in the study area located in New England, highlighting the need for improved reservoir systems, especially given the aging dams and higher risk of failures. Additionally, land cover changes, like the widespread defoliation caused by the Gypsy Moth infestations, affect water …

Novel Methodology And Proof-Of-Concept For Proton Ct Using Spot Profile Rather Than Bragg Peak Location, Brett Albert Ruben

Open Access Dissertations

Proton radiation therapy offers a highly precise method for cancer treatment, theoretically providing superior dose deposition characteristics compared to conventional X-ray radiation therapy. Its steep and finite dose fall-off region allows for superior tumor coverage while reducing, though not eliminating, dose to surrounding healthy tissue. However, its full potential is limited by range uncertainties, particularly those arising from the reliance on X-ray-based imaging methods called computed tomography (CT) for proton-based treatment. CT image Hounsfield Units (HU) must be converted to stopping power ratios (SPR) as these ratios are the clinically relevant value for accurately planning particle interactions during proton therapy. …

Entrepreneurial Selling And Business Success In Brazil, Renato Fernandes

Open Access Dissertations

This study aimed to deepen the understanding of the relationship between Entrepreneurial Selling and business success in Brazil through two different studies about the antecedents and consequences of Entrepreneurial Selling.

Using grounded theory and an exploratory-confirmatory mixed methods design, this dissertation demonstrates that Entrepreneurial Selling is crucial for business success. The database was sufficiently diverse for an in-depth analysis of the entrepreneurial Brazilian context: 777 entrepreneurs participated in the studies, ranging from first-time founders and serial entrepreneurs, leading B2B, B2C, and B2B2C companies from 31 segments, from startups struggling to make their first million to established companies already earning more …

Intersections Of Inattention: A Qualitative Inquiry Into The Experiences Of Multiply Marginalized Students In Community College Settings, Jana N. Knibb

Open Access Dissertations

Educational research has examined the impact of expanded access to higher education for historically marginalized groups. However, research on the experiences of students who are both racially minoritized and dis/abled is limited. Findings suggest that, due to their intersectional identities, multiply marginalized dis/abled students (MMDS) navigate policies and practices related to racist ableism, which further marginalize them and create additional barriers in their higher education experiences. Expanding this research requires theoretical frameworks that account for students' identities, experiences, and barriers in higher educational spaces and contexts. This qualitative study, grounded in Dis/ability Studies and Critical Race Theory in Education (DisCrit), …

Confronting The Seaport Resilience Gap: Incentives, Frameworks, And Case Studies For Enhancing Resilience To Natural Hazards In Port Planning And Policy, Rosemarie Fusco

Open Access Dissertations

This dissertation investigates the critical issue of seaport resilience, focusing on the gaps in resilience planning and the role of incentives in motivating resilience investment. The research arc addresses the question: What incentivizes seaports to increase natural hazard resilience (NHR)? It is organized into three interconnected manuscripts, each examining distinct aspects of the problem.

The first manuscript critically examines the resilience planning approaches of Small Island Developing States (SIDS) as outlined in their National Adaptation Plans (NAPs), highlighting the limited consideration of seaports despite their critical role in economic and social connectivity. SIDS offer critical insight into seaport resilience due …

Textual Sediments: Genre And The Planetary Novel, William Bowden

Open Access Dissertations

This dissertation investigates how twenty-first-century prose fiction navigates the ecological and temporal dimensions of planetary crisis. In response to accelerating pressures - climate change, ecological collapse, and the intensification of capitalist modernity - literary studies has turned increasingly to the planetary as a conceptual frame. Yet this shift has often outpaced the development of adequate critical vocabularies and narrative methodologies. By drawing on ecocriticism, narrative theory, phenomenology, and related fields, Textual Sediments proposes a new framework for reading what it terms the planetary novel: a sedimentary genre characterized by temporal layering, formal hybridity, and a recursive engagement with scale. Through …

Per- And Polyfluoroalkyl Substances (Pfas) Effects On Tissue Disposition, Proteome, And Health Effects, Juliana Agudelo Areiza

Open Access Dissertations

Per- and polyfluoroalkyl substances are a class of nonbiodegradable synthetic aliphatic environmental toxicants that are ubiquitous in the environment. A small subset, specifically perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA), have been designated as highly hazardous to human health by the Environmental Protection Agency (EPA) under the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA). PFOA and PFOS-associated adverse health effects include, but are not limited to, immune suppression, thyroid dysfunction, increased serum cholesterol, liver damage (i.e., alanine aminotransferase (ALT)), and developmental toxicity (i.e., low fetal birth weight and neurotoxicity). In this doctoral dissertation, it was hypothesized that environmental PFAS …

Coupled Numerical Modeling Of Wave-Current Interactions In Tropical Cyclones, Angelos Papandreou

Open Access Dissertations

This Ph.D. dissertation presents a numerical modeling study of wave-current interactions in tropical cyclones. Chapter 1 focuses on wave-current interaction in shallow water during hurricane landfall, when strong winds often generate severe storm surges that dramatically raise water levels and cause significant damage to human lives and property. Large waves generated by these winds further amplify storm surges, making it necessary to couple storm surge models with wave prediction models. Currently, two-dimensional coupled storm surge-wave models incorporate the effect of waves on the storm surge through the forcing of radiation stress gradients. However, recent studies on wave-current interactions indicate that …

"Understanding Obesity Experiences And Treatment Decision-Making In Hispanic-Latino Communities”, Viviane Fornasaro-Donahue

Open Access Dissertations

Obesity disproportionately affects Hispanic-Latino adults in the United States, yet rates of metabolic and bariatric surgery (MBS) remain lower in this population compared with non-Hispanic White adults. This dissertation comprises three interconnected phases aimed to (I) explore perceptions of obesity, obesity treatment, and patient-provider communication, (II) inform the development of a culturally responsive bilingual educational material about obesity and MBS, and (III) evaluate its acceptability among Hispanic-Latinos adults with obesity.

Phase I involved a qualitative exploration using semi-structured interviews with Hispanic-Latino adults (n=26) recruited from a community and a clinical MBS setting. These interviews explored participants’ perceptions of …

A Multispectral Analysis Of High Redshift Quasars And Their Energy Production Mechanisms, Erik Carlson

Open Access Dissertations

We present a complete sample of radio-loud (P_3.0 GHz = 10^27.26 W/Hz) high-redshift (z ≥ 2.5) quasars in the Northern Hemisphere (δ ≥ 0). Each source was imaged with a user-defined imaging protocol developed for the Very Large Array Sky Survey. Higher-resolution images were generated from archival observations and new Enhanced Very Large Array observations (Project Code: 24B-010).  We produced 407 images of galaxies, where we are likely the first humans to see them. Twenty of these sources were high-redshift jets which increased the number of known high-redshift jets by 69%. This sample represents one of the largest …

Synthesis And Evaluation Of Anti-Hiv Activity Of Fatty Acyl Conjugates Of Tenofovir Alefanamide, Muhammad Sajid, Naglaa Salem El-Sayed, Louise A. Ouattara, Amita Verma, Gustavo F. Doncel, Keykavous Parang, M. Iqbal Choudhary, Hina Siddiqui

CONRAD Publications

The activity of nucleoside and nucleotide analogs as antiviral agents requires phosphorylation by intracellular enzymes. Phosphate-substituted analogs have low bioavailability due to the presence of ionizable negatively-charged groups. To circumvent this limitation, several prodrug approaches have been proposed and developed. Herein, we hypothesized that the conjugation of anti-HIV fatty acids with the nucleotide tenofovir alafenamide (TAF) (1) could improve the anti-HIV activity of the nucleotide. Several fatty acyl amide conjugates of TAF were synthesized and evaluated in comparative studies with TAF. The synthesized compounds were evaluated as racemic mixtures for anti-HIV activity in vitro in a single-round HIV-1 infection assay …

Environmentally Friendly Chelation For Enhanced Algal Biomass Deashing, Agyare Asante, George Daramola, Ryan W. Davis, Sandeep Kumar

Civil & Environmental Engineering Faculty Publications

High ash content in algal biomass limits its suitability for biofuel production by reducing combustion efficiency and increasing fouling. This study presents a green deashing strategy using nitrilotriacetic acid (NTA) and deionized (DI) water to purify Scenedesmus algae, which was selected for its high ash removal potential. The optimized sequential treatment (DI, NTA chelation, and DI+NTA treatment at 90–130 °C) achieved up to 83.07% ash removal, reducing ash content from 15.2% to 3.8%. Elevated temperatures enhanced the removal of calcium, magnesium, and potassium, while heavy metals like lead and copper were reduced below detection limits. CHN analysis confirmed minimal …

Streamlining Wildlife Regulation, Robert L. Fischman

Articles by Maurer Faculty

A recent burst of revisions in the bedrock regulations governing projects that may adversely affect wildlife represents a generational shift in policy. Streamlining federal decision -making drove much of this reform. Streamlining offers a path to address climate change without abandoning a longstanding commitment to wildlife conservation. The conservation community recognizes the need to build new infrastructure to reduce the rate of climate change through air emissions. The most urgent priority is decarbonizing the electrical ~rid through renewable energy generation and a better transmission network. Adaptation to the "new abnormal" of climate-driven environmental disruption demands federal approvals for a host …

International Students’ Perceptions And Experiences Of Institutional Diversity Initiatives And Self-Authorship Attainment: A Mixed Methods Study, Sandra Ayivor

Graduate Theses, Dissertations, and Problem Reports (ETD)

Higher education institutions in the United States have responded to years of discrimination through several diversity initiatives. Although research has indicated the merits of such initiatives on student development, the outcomes are not uniform across all student populations. Moreover, student development discourses have often excluded the experiences of international students. Employing a convergent mixed methods approach, this study investigated the perceptions and experiences of international students at a flagship land-grant higher education institution in the Appalachian region of the United States regarding institutional diversity initiatives and their self-authorship based on some demographic characteristics (i.e., gender, age, marital status, religion, continent, …

Assessing The Feasibility Of The Virtual Reality Training Protocol For Sport, Jarad A. Lewellen

Graduate Theses, Dissertations, and Problem Reports (ETD)

Research has supported the use of virtual reality (VR) in sport to train skills such as decision-making and anticipation, as well as aid in injury rehabilitation. Despite this, VR is not commonly used as a training tool in sport. Barriers to its adoption include a lack of understanding, low awareness, and risk of cybersickness. As such, there is a critical need to address these barriers and promote acceptance of VR in sport. The purpose of this single-arm, non-randomized, mixed-methods feasibility trial was to examine the feasibility and acceptability of the Virtual Reality Training Protocol for Sport (VRTPS), which was designed …

Exploring Teacher Perception And Implementation Of Sae Programming In West Virginia, Joseph Laflamme

Graduate Theses, Dissertations, and Problem Reports (ETD)

The purpose of this study was to describe the phenomenon of SAE implementation in West Virginia. This study utilized qualitative research methodology to describe teacher perceptions of how student, guardian, school and community factors affect SAE program implementation. Additionally, teacher backgrounds, including formative experiences, training and education, guiding philosophies, skills, and motivation were explored. This study describes contextual aspects of population, economics, state guidelines and local agriculture industries. This is done through a document review of student reported records as well as surveys and teacher interviews.

A Difference-In-Differences Investigation Of The Impact Of State-Mandated Campus Carry Laws In Texas On Violent Campus Crime Rates, Ryan Matthew Gibson

Graduate Theses, Dissertations, and Problem Reports (ETD)

The purpose of this study is to examine the potential impact of state-mandated campus carry laws on sexual misconduct and other violent crime statistics at public, four-year institutions. The study focuses on the state-mandated campus carry law put into effect in Texas starting in 2016 to analyze whether or not it had an impact on campus crime rates. Findings of the study showed that reported campus crime increased at Texas institutions post-2016 at a larger rate than the states that explicitly ban campus carry. Due to a lack of data on the number of individuals carrying guns on campuses in …

"She's Such A Nice Girl": Exploring The Literacy And Identity Formation Practices Of Black Girls In White, Appalachian Communities, Tamicah Tierra Owens

Graduate Theses, Dissertations, and Problem Reports (ETD)

This study examines the experiences and stories of two Black girls in predominantly White Appalachian communities, focusing on the language and literacy practices they employ to navigate and make sense of their Black feminine identities. It focuses on how literacy and language skills acquired from spending quality time with their mothers, engaging in various spaces with friends, and engaging in interest-driven traditional media and/or social media helped them to analyze their communities’ and the larger landscapes’ discourses around race and gender to create and modify their desired identities. This qualitative study employs narrative case study to center the lived experiences …