Digital Commons Network^™

Atrial Myocyte Ampk Deletion Alters Single Nuclear Profiles In Mice, Julia Nicole Eisen

Yale Medicine Thesis Digital Library

Atrial fibrillation (AF) is the most common arrhythmia worldwide with about 1 in 4 adults expected to develop the condition in their lifetime. AMP-activated kinase (AMPK) is a critical energy sensor and regulates tissue energy and substrate metabolism. Our lab has previously shown that atrial cardiomyocyte-specific cardiac AMPK deletion induces electrophysiologic changes, left atria structural remodeling and spontaneous AF. The mechanism by which loss of AMPK and consequent metabolic stress leads to AF has not yet been elucidated. Using single nuclear RNA sequencing (snRNA sequencing) of mouse heart atria from mice with atrial cardiomyocyte AMPK deletion, we begin to investigate …

Mass Sars-Cov-2 In A State Correctional System During The Pandemic, Charlotte Kim

Yale Medicine Thesis Digital Library

Mass screening has been shown to be more efficient in identifying infections in correctional facilities compared to symptom-based screening, but little is known about the impact of systematic mass screening on timely isolation of infectious cases over the course of the entire pandemic. Between March 2020 and May 2023, the Connecticut Department of Correction (CT DOC) performed a multifaceted SARS-CoV-2 testing strategy for its incarcerated population, which included RT-PCR for mass screening, as well as rapid antigen testing for contact tracing, symptom-based screening, and other miscellaneous reasons. Testing data reveals that mass screening identified 48% of all positive results, whereas …

Pregnancy Outcomes After Glp-1 Receptor Agonist Exposure And Ethical Considerations, Nishita Pondugula

Yale Medicine Thesis Digital Library

The objective of this study is 1) to understand the effect of GLP-1 receptor agonist (GLP-1RA) use in the year prior to conception on risk of developing hypertensive disorders of pregnancy (HDP) and on gestational weight gain (GWG), and 2) to analyze important ethical considerations relevant to research in pregnancy and specifically related to GLP-1RAs.All patients delivering between 2014-2024 with evidence of GLP-1RA exposure in the year prior to conception were identified through electronic medical record (EMR) query with hand review to confirm exposure. GLP-1RA exposed patients were classified according to GLP-1RA indication for use: 1) pregestational diabetes mellitus (PGDM) …

Macrophage Migration Inhibitory Factor And D-Dopachrome Tautomerase As Biomarkers And Key Modulators Of Tumor Progression In Head And Neck Cancer And Melanoma, Caroline Naomi Valdez

Yale Medicine Thesis Digital Library

Macrophage Migration Inhibitory Factor (MIF) and its homolog D-dopachrome Tautomerase (DDT) are pro-inflammatory cytokines implicated in tumor progression across multiple cancers. Both MIF and DDT act through canonical CD74 and non-canonical CXCR2/4/7 signaling pathways, which contribute to immune suppression and tumor progression. Elevated MIF levels are associated with metastasis and poor prognosis in HNC and contribute to immune checkpoint inhibitor (ICI) resistance in melanoma. DDT’s role in cancer is not well understood. This study aims to evaluate the expression and therapeutic potential of MIF and DDT inhibition, focusing on their ability to modulate immune responses and improve survival outcomes as …

Neurosurgical Praxis Guidelines During The Covid-19 Outbreak. Consensus-Based On Currently Available Literature., José Antonio Soriano Sánchez, Bárbara Nettel Rueda, José Alberto Israel Romero Rangel, Armando Alpizar Aguirre, Miguel Ángel Andrade-Ramos, Ulises García Dr., Diego Mendez Rosito, Jorge A. Santos, Sara Patricia Pérez Reyes, Julian Eduardo Soto Abraham, Jose E. Valerio Pascua, Marco Antonio Barajas Romero, Eduardo Díaz Juárez, Alma Griselda Ramírez Reyes, Maria Elena Gonzalez, Claudia Katiutska González Valdez, Félix Domínguez Cortinas, Noé Santiago Ramírez, Tenoch Herrada Pineda, Manuel Eduardo Soto García, Edgar Nathal Vera, Gustavo Melo Guzmán

Archives of Neurosurgery

INTRODUCTION: The World Health Organization recommended several strategies to contain the COVID-19 pandemic, including optimization of care for all patients, especially the seriously ill. Given the strain, the pandemic has posed on healthcare systems around the world, many neurosurgical associations have provided triage recommendations for patients to save resources for the pandemic. We aimed to provide practical recommendations based on specific illnesses requiring surgical procedures commonly performed by neurosurgeons on a life-threatening basis of patient illness. We consider this guideline will help neurosurgeons for the appropriate triage of patients on a daily-situation basis during this pandemic.

METHODS: The Mexican Society …

Mandatory Public Reason-Giving In Corporate Governance, Sarah C. Haan

Scholarly Articles

Since the late 1970s, corporate governance law has incorporated a growing number of mandates that require corporate boards to explain to their shareholders the reasons behind their decision-making. These mandates do more than merely require boards to disclose certain decisions. They compel boards to publicly state why they have made a particular choice.

Public reason-giving is a core democratic value that recognizes the accountability of a representative body to its constituents. It provides a basis for constituents to assess the quality of leaders’ decision-making and to engage with that decision-making in effective ways. In corporations, public reason-giving facilitates the shareholder’s …

Natalie Collins, Wilmer Amina Carter Foundation

Bridges Digital Archive: Audio and Video Recordings

In this recording, Natalie Collins is the guest being interviewed by her adult child. She is asked about her life living in Southern California, to which she talks about being in a large family and how schools were segregated and integrated. She also speaks about the dairy farm her family had, which was run by her father to support his family. She then talks about how her parents separated and explains how living between parents changed the way she and her siblings attended school. After a brief discussion of how her mother preferred ice boxes to fridges and the friends …

South Dakota Farmers Alliance Records, Sdsu Archives And Special Collections, Hilton M. Briggs Library

Manuscript Archive

The South Dakota Farmers Alliance Records document the early agricultural reform movement in Dakota Territory, focusing on farmers’ efforts to organize against economic hardships and railroad monopolies. The collection includes an 1887 address by President H. L. Loucks, proceedings from the Alliance’s annual convention that same year, and an undated advertisement for A Book for Farmers – Dunning’s Farm Ledger and Historical Account. These materials reflect the Alliance’s advocacy for economic reforms, railroad regulation, and farmer education.

The South Dakota Farmers’ Alliance emerged in the early 1880s, influenced by the National Farmers’ Alliance, and driven by declining wheat prices …

Annual Reports Of The Selectmen And Other Town Officers Of The Town Of Langdon, N.H. For The Year Ending December 31st, 2024, Langdon Town Representatives

Langdon, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

"Reasonable [Cybersecurity] Measures" For Digital Trade Secrets: Lessons From Marketing, Raj Sachdev

Law Faculty Scholarship

The loss of digital trade secrets in marketing and beyond, often the source of competitive advantage, can have disastrous impacts on brands and companies. Bad actors want to get their digital hands on digital trade secrets, and other actors and factors may also cause a risk to their secrecy. The Defend Trade Secrets Act (DTSA) makes clear that “reasonable measures” must be taken to maintain the secrecy of a trade secret. Likewise, the Uniform Trade Secrets Act (UTSA) requires “reasonable steps.” However, in a digital age, the definition of what is “reasonable” is even more unclear than in offline settings. …

Merrimack County New Hampshire Annual Report, Fiscal Year 2024, January 1st - December 31st, Merrimack County Representatives

Merrimack County, NH Annual Reports

This is an annual report containing vital statistics for a county in the state of New Hampshire.

A Landscape Analysis Of Civic And Community Engagement In Community Colleges, Carrie Kisker, Carol Cutler White, Stephanie King, Janet Johnson, Will Bowlin

CoE Publications

Providing opportunities for civic learning and democratic engagement has been central to the community college mission for over 100 years. This report presents findings from the 2024 AmeriCorps Civic Engagement among Community Colleges Project (ACECCP) survey, highlighting the ways and extent to which community colleges demonstrate an intentional commitment to civic and community engagement, illustrating how they incorporate this intentionality into curricular and co-curricular structures, and identifying the barriers and challenges that may preclude some colleges from engaging more fully in their civic mission. The report offers recommendations for future research on the positive impacts of community colleges in their …

Preservice Teachers' Perceptions Of Gifted Students' Characteristics And Needs, Courtney Warren

Masters Theses & Specialist Projects

Gifted students possess unique needs that require appropriately challenging opportunities to develop their advanced abilities. To meet these needs, gifted students must be correctly identified, which is often through teacher referral, thus subjecting the identification process to teachers’ knowledge and perceptions of giftedness. Teachers can also implement practices, such as differentiation, to meet gifted needs within their own classrooms. Thus, teachers must hold accurate perceptions of gifted students and their needs. However, teacher preparation programs often offer minimal training in giftedness. The purpose of the current study was to examine preservice teachers’ perceptions of gifted students’ characteristics and needs. Thirty-one …

Examining Antecedents Of Diversity Initiative Fatigue: A Moderatedmediation Model, Anne Simpson

Masters Theses & Specialist Projects

This thesis investigates the relationships between bias awareness, motivation to respond without prejudice, racialized attitudes, and diversity initiative fatigue (DIF) among employees within an academic setting, specifically focusing on faculty and staff at Western Kentucky University. Data were collected through a survey-based approach to measure these constructs and assess their relationships. This study hypothesized that bias awareness negatively correlates with DIF and motivation to respond without prejudice mediating this relationship. Furthermore, the research examines how racialized attitudes moderate the relationship between bias awareness and motivation to respond without prejudice. By examining these relationships using a moderated mediation model, the study …

Examining The Impact Of A Mobile-Delivered Brief Intervention On Substance Coping Motives Among A Sample Of Interpersonal Trauma Survivors With Heavy Alcohol Use, Lily Milam

Masters Theses & Specialist Projects

Brief interventions (BIs) aim to reduce risky alcohol use but show limited effectiveness for interpersonal trauma (IPT) survivors, who may use alcohol to cope with trauma-related issues. BIs typically do not target coping-related motivations or include effective emotion regulation strategies, which may improve outcomes for at-risk groups like IPT survivors. Additionally, digital interventions often struggle with low engagement. This study examined a trauma-informed and peer-supported BI to reduce coping-related drinking motives in heavy drinking young adults and assess its effectiveness compared to a standard BI and assessment only condition. Participants (N=133, 79.2% Female, 91.2% White, M age=19.77) with a lifetime …

Characterization Of Legionella Pneumophila Effector Protein Ceg10, Emmanuella Ofoka

Masters Theses & Specialist Projects

Legionella pneumophila, the causative agent of Legionnaires' disease, utilizes a Type IV secretion system (T4SS) to transport effector proteins into host cells. This bacterium is said to have over 300 effector proteins. Among these, the Ceg10 effector protein had remained uncharacterized, despite evidence suggesting the importance of bacterial effector proteins in the host-pathogen interaction. This study aimed to perform a structural and functional characterization of Ceg10 through transcriptomic, bioinformatics, and molecular analyses. Transcriptomic profiling of HEK 293T cells expressing Ceg10 revealed significant differential gene expression, with approximately 20 upregulated genes, including leucine-rich repeat, as well as other downregulated genes. …

Personality And How It Relates To Coping Flexibility, Rebecca Kearns

Masters Theses & Specialist Projects

Stressful events, negative emotions, and negative events are all a normal part of life. How we react and cope with these events can reduce the damage stress can have on our mental health and well-being. There are many ways to cope with situations, but not all are considered to be beneficial. The ability to alternate between different coping strategies within a given situation is called coping flexibility. Having high coping flexibility is considered to be healthy and adaptive, but not everyone possesses the ability to flexibly cope with situations. Personality may explain individual differences among coping flexibility. The big five …

Kettlebell Swings As A Conditioning Activity On Standing Power Throw: Exploring Post-Activation Performance Enhancement In Rotc Cadets, Knik Durman

Masters Theses & Specialist Projects

Post-activation performance enhancement (PAPE) is a neuromuscular phenomenon where high-intensity conditioning activities (CA) temporarily improve explosive performance. While resistance and ballistic exercises are well-studied for PAPE, the effectiveness of kettlebell swings (KBS) in enhancing Standing Power Throw (SPT) performance remains unclear. Given the SPT’s role in the Army Combat Fitness Test (ACFT), identifying effective PAPE strategies could improve ACFT scores. Using a randomized crossover design, this study examined whether KBS before the SPT enhanced throw distance in 19 ROTC cadets (male: n = 17, female: n = 2). Participants completed two conditions: (1) KBS (two sets of five reps with …

Social Comparison And Pressure: Examining The Roles Of Sex And Rank, Ashley East

Masters Theses & Specialist Projects

Faculty in academia face intense competition and growing expectations, often shaped by perceptions of others’ performance. During the COVID-19 pandemic, these dynamics were magnified, making social comparison a critical factor in understanding academic workplace pressures. The purpose of this study is to examine the changing work pressures and social comparison tendencies among academics during the COVID-19 pandemic. It is hypothesized that social comparison tendencies will be positively related to time pressure (H1a) and telepressure (H1b), with moderation by sex (H2a and H2b) and organizational rank (H3a and H3b). Using a panel survey of 197 tenure-track and tenured faculty members in …

Diversity And Phylogeny Of Spider Beetles (Ptinidae: Ptininae) In Coastal Chile And Peru, Jacob Bowen

Masters Theses & Specialist Projects

Spider beetles of South America have historically received little systematic study, though now they are the subject of recent diversity surveys and documentation. This investigation contributes to the ongoing exploration of spider beetle diversity in South America by adding records for the recently described Cordielytrum and the yet to be described Furcillifer, as well as constructing phylogenies with new genetic material. MaxEnt was used to create an ecological niche model revealing habitat suitability in Chile and Peru for Cordielytrum, a genus of flightless spider beetles currently known only from Peru. Even with few occurrence records, a model with …

Supplementary Materials To "Preindustrial Inequality In Mexico", Amilcar Challú, Israel García Solares, Aurora Gómez-Galvarriato

History Faculty Publications

Supplementary material to "Preindustrial Inequality in Mexico" by Amílcar Challú, Israel García Solares, Aurora Gómez-Galvarriato, in Preindustrial Inequality in Latin America, edited by María Inés Moraes and Amílcar E. Challú (Routledge, forthcoming 2026).

Nsu Communiversity Outreach, Nova Southeastern University

NSU Digital: Communiversity

No abstract provided.

College Students’ Beliefs: Association Between Skin Color And Acceptance, Christopher James Thompson

Theses and Dissertations

The Multiracial population represents the fastest-growing demographic group in the United States and is expected to more than double by 2060 (Vespa et al., 2018). Despite this rapid increase in the Multiracial population, there is a dearth of research regarding racial identity development, anxiety, and depression on this group. Social inclusion has been recognized as a fundamental human need, and Multiracial individuals may be more likely to be accepted into a majority group if their appearance is racially ambiguous. The current study builds on previous knowledge by utilizing a novel measure developed to examine the beliefs held by Monoracial and …

Special Education Teachers’ Burnout: Exploring The Impact Of Special Education Setting And Teaching Experience, Adriana Noel Haugen

All Electronic Theses and Dissertations

This quantitative study investigated the extent to which special education teachers' perceptions of burnout are associated with two contextual variables: federal instructional setting and years of teaching experience. Although burnout in special education is well documented, few studies have examined how these particular factors influence reported levels of burnout. A total of 15,412 licensed special education teachers in Minnesota, including those with Tier 1 through Tier 4 licenses and Out of Field Permission, were invited to participate. Of these, 1,468 completed the Copenhagen Burnout Inventory, a validated instrument measuring personal, work-related, and student-related dimensions of burnout. Participants were grouped by …

Rapid Adaptation Of Intra-Operative Strategies For Transurethral Cystoscopic Procedures In Response To Intravenous Fluid Shortage, Emily Y. Huang, Rijul Nandi, Kevin P. Nguyen, Ricardo R. Gonzalez

Gulf Coast Division GME Research Day 2025

No abstract provided.

Increasing Academic Engagement In Underserved Elementary Students, Molly K. Boss

All Electronic Theses and Dissertations

The issue of student disengagement has been troubling teachers and school systems for years. The COVID crisis brought the issue to the forefront and renewed attention to the critical effects of disengagement on students’ academic and life prospects, most significantly - on marginalized students. This study analyzes the effects of disengagement and the factors that influence student disengagement. It also provides practical tools and strategies that can be implemented to promote engagement for underserved students. The goal of this literature review is to increase the understanding of disengagement and its effects on underserved students and to equip educators with tools …

Neurocognitive Teaching Strategies In The English Language Learner Classroom, Susan Annette Biasco

All Electronic Theses and Dissertations

The emergence of advanced medical technology in the past 30 years has allowed doctors and researchers to look inside the brain to more accurately model cognition and memory. The concept of neuroplasticity has replaced the outdated idea that we are born with all the brain connections we will ever have. Based on these new discoveries, neurocognitive teaching strategies seek to apply the model of how the brain learns best to classroom pedagogy. Teaching techniques that put the student at the center of the equation, instead of the teacher, have been repeatedly shown in the research to improve learning and knowledge …

Investigating The Relationship Of Feminization Of Education And Teacher Attrition, Kate Irene Toriseva Trosen

All Electronic Theses and Dissertations

The feminization of teaching has taken place over multiple centuries, born of a mixture of social-political movements which reveal current complex issues leading to a shortage of young women entering and staying in education careers. Through a review of literature and study on the subjects of educational feminization, teacher attrition, and female workplace concerns and preferences, this thesis assessed the correlations between current teacher shortages and female-based causes and solutions. By assessing these reasons, studying the working habits of women, and evaluating teachers’ reported concerns and reasons for leaving the classroom, this literature review identified important causational effects directly related …

Use Of Va Ecmo In Patients With Acute Pulmonary Embolism Presenting With Obstructive Cardiogenic Shock Undergoing Mechanical Thrombectomy, Luke Taylor, Otoniel Espinoza, Omar O. Hernandez, Shannon Biggers, Shirin Miller, Srinivas Yallapragada, Amer Alaiti, Andrew Fredericks, Song Li, Claudius Mahr

North Texas Research Forum 2025

Background Patients with massive/sub-massive pulmonary embolism (PE) and right ventricular strain have a significant risk of hemodynamic collapse. VA ECMO support provides an excellent salvage option for patients with acute/unstable pulmonary embolism with obstructive cardiogenic shock undergoing mechanical thrombectomy. Using VA-ECMO for a “protective PE” procedure allows control of hemodynamics and enables interventionalists to perform the thrombectomy in a more controlled environment. Here, we present our experience. Methods A retrospective data analysis on consecutive VA ECMO patients with cardiogenic shock secondary to pulmonary embolism was abstracted from August 2022 to June 2024. Results Patient characteristics and outcomes are described in …

Smokejumper Biographies For 1943 Rookie Class, National Smokejumper Association

Smokejumper Biographies by Rookie Year

This document contains short biographies of smokejumpers who rookied in 1943.