Digital Commons Network^™

Cancer Cells Avoid Ferroptosis Induced By Immune Cells Via Fatty Acid Binding Proteins, Maria Angelica Freitas-Cortez, Fatemeh Masrorpour, Hong Jiang, Iqbal Mahmud, Yue Lu, Ailing Huang, Lisa K Duong, Qi Wang, Tiffany A Voss, Claudia S Kettlun Leyton, Bo Wei, Wai-Kin Chan, Kevin Lin, Jie Zhang, Efrosini Tsouko, Shonik Ganjoo, Hampartsoum B Barsoumian, Thomas S Riad, Yun Hu, Carola Leuschner, Nahum Puebla-Osorio, Jing Wang, Jian Hu, Michael A Davies, Vinay K Puduvalli, Cyrielle Billon, Thomas P Burris, Philip L Lorenzi, Boyi Gan, James W Welsh

Faculty, Staff and Student Publications

Background: Cancer creates an immunosuppressive environment that hampers immune responses, allowing tumors to grow and resist therapy. One way the immune system fights back is by inducing ferroptosis, a type of cell death, in tumor cells through CD8 + T cells. This involves lipid peroxidation and enzymes like lysophosphatidylcholine acyltransferase 3 (Lpcat3), which makes cells more prone to ferroptosis. However, the mechanisms by which cancer cells avoid immunotherapy-mediated ferroptosis are unclear. Our study reveals how cancer cells evade ferroptosis and anti-tumor immunity through the upregulation of fatty acid-binding protein 7 (Fabp7).

Methods: To explore how cancer cells resist immune cell-mediated …

Understanding Pediatric Bipolar Disorder Through The Investigation Of Clinical, Neuroanatomic, Neurophysiological And Neurocognitive Dimensions: A Pilot Study, Alessio Simonetti, Evelina Bernardi, Sherin Kurian, Antonio Restaino, Claudia Calderoni, Emanuela De Chiara, Francesca Bardi, Gabriele Sani, Jair C Soares, Kirti Saxena

Faculty, Staff and Student Publications

Background: Pathophysiological models of pediatric bipolar disorder (PBD) are lacking. Multimodal approaches may provide a comprehensive description of the complex relationship between the brain and behavior. Aim: To assess behavioral, neuropsychological, neurophysiological, and neuroanatomical alterations in youth with PBD.

Methods: Subjects with PBD (n = 23) and healthy controls (HCs, n = 23) underwent (a) clinical assessments encompassing the severity of psychiatric symptoms, (b) neuropsychological evaluation, (c) analyses of event-related potentials (related to the passive viewing of fearful, neutral, and happy faces during electroencephalography recording, and (d) cortical thickness and deep gray matter volume measurement using magnetic …

Racial Differences In Ctdna Profiles, Targeted Therapy Use, And Outcomes In Metastatic Breast Cancer, Emily L Podany, Katherine Clifton, Shaili Tapiavala, Foluso O Ademuyiwa, Cynthia X Ma, Andrew A Davis, Et Al.

2020-Current year OA Pubs

IMPORTANCE: Black patients with metastatic breast cancer (mBC) have higher mortality rates than White patients despite advances in treatment.

OBJECTIVES: To examine whether Black patients with metastatic breast cancer have different genomic profiles compared with White patients and whether there are inequities in targeted treatment use between these groups.

DESIGN, SETTING, AND PARTICIPANTS: This retrospective, population-based cohort study assessed adult patients with mBC who underwent genomic profiling at academic institutions in the US between January 1, 2015, and December 31, 2023. Data analysis was performed between July 2023 and July 2024. A validation cohort was also included.

EXPOSURES: Targeted treatment …

Differential Impact Of Lymphatic Outflow Pathways On Cerebrospinal Fluid Homeostasis, Zachary Papadopoulos, Leon C D Smyth, Igor Smirnov, Daniel A Gibson, Jasmin Herz, Jonathan Kipnis

2020-Current year OA Pubs

Dysfunctional lymphatic drainage from the central nervous system (CNS) has been linked to neuroinflammatory and neurodegenerative disorders, but our understanding of the lymphatic contribution to CNS fluid autoregulation remains limited. Here, we studied forces that drive the outflow of the cerebrospinal fluid (CSF) into the deep and superficial cervical lymph nodes (dcLN and scLN) and tested how the blockade of lymphatic networks affects CNS fluid homeostasis. Outflow to the dcLN occurred spontaneously in the absence of lymphatic pumping and was coupled to intracranial pressure (ICP), whereas scLN drainage was driven by pumping. Impaired dcLN drainage led to elevated CSF outflow …

A Comprehensive Head-To-Head Comparison Of Key Plasma Phosphorylated Tau 217 Biomarker Tests, Noëlle Warmenhoven, Nicolas R Barthélemy, Suzanne E Schindler, Andrew J Aschenbrenner, Cyrus A Raji, Tammie L S Benzinger, John C Morris, Laura Ibanez, Jigyasha Timsina, Carlos Cruchaga, Randall J Bateman, Et Al.

2020-Current year OA Pubs

Plasma phosphorylated-tau 217 (p-tau217) is currently the most promising biomarker for reliable detection of Alzheimer's disease pathology. Various p-tau217 assays have been developed, but their relative performance is unclear. We compared key plasma p-tau217 tests using cross-sectional and longitudinal measures of amyloid-β (Aβ)-PET, tau-PET and cognition as outcomes and benchmarked them against CSF biomarker tests. Samples from 998 individuals [mean (range) age 68.5 (20.0-92.5) years, 53% female] from the Swedish BioFINDER-2 cohort, including both cognitively unimpaired and cognitively impaired individuals, were analysed. Plasma p-tau217 was measured with mass spectrometry assays [the ratio between phosphorylated and non-phosphorylated (%p-tau217WashU) and p-tau217WashU] and …

Method For Optical Measurement Of Relative Humidity In A Fuel Cell System, Anonymous

Defensive Publications Series

Proper membrane hydration is critical to the performance of a fuel cell powertrain, which is an important potential low-carbon energy system for future medium- and heavy-duty vehicles. However, direct measurement of relative humidity in a fuel cell gas stream is complicated by multiple factors. First, the sensor must be able to operate within an environment with elevated temperature and pressure. Additionally, the de-ionized water used in such systems can leach metals and is therefore not compatible with all materials. Finally, the sensor must not only be accurate, but must have sufficient time resolution to capture important transient information from the …

Required Related: Why Music And Audio Technology Courses Are Not Enough For Success In The Music Industry, Barry G. Atticks, Dain Estes

Journal of the Association for Technology in Music Instruction

This pilot study evaluates the relevance of ancillary courses (required related) in music technology curricula, emphasizing the alignment of academic offerings with industry needs. While core subjects like studio recording and sound design are well-studied, this research focuses on related courses outside the primary sequence, including technology, business, industry-specific, core music, and education courses. Surveying 20 professionals across various music technology sectors, we assessed the importance of topics such as basic electronics, wireless systems, media studies, and industrial safety. Results indicate that basic electronics and wireless systems are crucial. Media studies and industrial safety courses are also valued highly, though …

Mnet 315-102: Industrial Statistics, Edwin May

School of Applied Engineering and Technology Syllabi

No abstract provided.

Most Infants With Prenatal Osteogenesis Imperfecta Diagnosis And Poor Prognosis Survive: Experience Of A Quaternary Care Osteogenesis Imperfecta Center, Ricki S. Carroll, Sarah Little, Tina Mcgreal, Shannon Bonner, Daria Willis, Jeanne M. Franzone, Jeffery Campbell, Margaret Chou, Megan B. Raymond, Andrea Schelhaas, Joanna Costa, Mahim Jain

Department of Obstetrics and Gynecology Faculty Papers

Osteogenesis imperfecta is a genetic condition with improperly or inadequately produced Type I collagen. Manifestations include bowing deformities, fractures, hydrocephalus, respiratory insufficiency, and feeding difficulty. Moderate or severe OI is often diagnosed prenatally based on ultrasound findings and genetic testing may be labeled as lethal. Here, we present 18 infants with moderate to severely presenting OI who received neonatal care at a single center over a 5 yr period, 10 of which were delivered at our institution. All 18 infants survived to neonatal discharge, with 7 infants requiring respiratory support and 9 infants requiring feeding support at discharge. Through Fisher …

Pharmacogenetic And Microrna Mechanisms Of Beta Blocker Use On Bone, Christine W Lary, Elizabeth J Atkinson, Jennifer Spillane, Zannatun Nayema, Tyler A Roy, Rebecca Peters, Griffin T Scott, Hongyu Chen, Archana Nagarajan, Aaron Brown, Katherine J Motyl, David G Monroe, Sundeep Khosla

Faculty, Staff and Students Publications

Motivated by studies showing an association between beta blocker (BB) use and positive bone outcomes, a pilot randomized control trial was performed at the Mayo Clinic which randomized postmenopausal women to placebo, propranolol (40 or 80 mg twice daily), atenolol (50 mg/d), or nebivolol (5 mg/d) to determine changes in bone turnover markers (BTMs) and in BMD over 20 wk. Pharmacogenetic effects and microRNA-mediated mechanisms involving beta adrenergic receptor and related genes have previously been found. We sought to validate these effects and discover new candidates in an ancillary study to the pilot clinical trial. We genotyped all participants and …

Cardiovascular Disease In Adults With Osteogenesis Imperfecta: Clinical Characteristics, Care Recommendations, And Research Priorities Identified Using A Modified Delphi Technique, Lars Folkestad, Siddharth K Prakash, Sandesh C S Nagamani, Niels Holmark Andersen, Erin Carter, Jannie Dahl Hald, Riley J Johnson, Bente Langdahl, Eleanor M Perfetto, Cathleen Raggio, Stuart H Ralston, Robert A Sandhaus, Oliver Semler, Laura Tosi, Eric Orwoll

Faculty, Staff and Student Publications

Osteogenesis imperfecta (OI) is a multisystem disorder most often caused by pathogenic variants in genes that encode type I collagen. Type I collagen is abundant not only in bone but also in multiple tissues including skin, tendons, cornea, blood vessels, and heart. Thus, OI can be expected to affect cardiovascular system, and there are numerous reports of cardiovascular disease (CVD) in people with OI. However, there is no consensus on how CVD in OI should be assessed or managed. To fill this gap, a multidisciplinary group was convened to develop clinical guidance. The work included a systematic review of the …

Volume 37-1 Complete Issue, C. Nicholas Raphael

The Geographical Bulletin

Volume 37-1 Complete Issue

The Effect Of Meteorological Conditions On Fly Ball Distances In North American Major League Baseball Games, Mark D. Kraft, Brent R. Skeeter

The Geographical Bulletin

This study examines the effect of meteorological conditions on the flight of baseballs hit in North American major league baseball games. Statistical analyses are used to relate game-time temperature, humidity, wind speed and wind direction data to the flight distance of every fair fly ball hit in non-domed stadiums during the 1991 and 1992 seasons. Results indicate that temperature is the most important meteorological variable affecting fly ball distances at most stadiums. The effect of wind speed and direction varies in different stadiums, with surprising influences at certain stadiums. The results of this study may be strategically valuable to managers …

The Renaming Of A Tennessee Region, John Morgan, Leonard W. Brinkman

The Geographical Bulletin

The northeastern section of Tennessee has been known as Upper East Tennessee since the 1840s. During the last few years, however, a new regional label, Northeast Tennessee, has been promoted as a more appropriate regional name. The push for a shift from the use of Upper East Tennessee to Northeast Tennessee has been spearheaded by agencies whose missions are to increase tourism and to attract new industry in the region. The local medianewspapers, radio, and television-have played key roles in the renaming process. Although there is some opposition to the new name, a campaign to designate the region as Northeast …

The Elderly Return-Migration In The United States: Role Of Place Attributes And Individual Characteristics In Destination Choice, Rshood M. Khraif

The Geographical Bulletin

The return migration of the aged is analyzed using a logit model that integrates selected place attributes (i.e., climate, living costs, and health services), distance to the state of birth, and several personal characteristics (i.e., gender, marital status, age, and income). A five-percent Publ ic Use Microdata sample of the 1980 Census of the United States of America is utilized in this paper. Results indicate that a recently retired elderly person is likely to select his/ her place (state) of birth if it has a pleasant climate and low living costs. Also the less wealthy and single people are more …

The Age Of Light: An Overview Of Arab Geography In The Middle Ages, Elizabeth A. Gutierrez

The Geographical Bulletin

The Medieval Arab world was a time of curiosity and inquiry, and many contributions to the knowledge of the earth were made during this period. Scientific study was strongly encouraged by many of the caliphate leaders. For this reason, we can call this period the "Age of Light." In contrast, many scientific studies during the " Dark Ages" of Medieval Europe were hindered by the Christian Church. Unfortunately, many Western scholarly accounts of the Middle Ages ignore the writings of Arab geographers. This study highlights the findings and theoretical underpinnings of selected Medieval Arab geographical works. It also discusses why …

A Review On Exploring Artificial Intelligence Applications, Advancements, Issues, And Future Challenges, Sajid Naeem, Novman Nabeel, Waseem Beg, Shujaat Ali, Rajiv N. Kanojiya, Satish S. Mandawade, Chetan R. Yewale, Sc Kulkarni, Vt Salunke, Av Patil

Polytechnic Journal

Artificial intelligence (AI) is a transformative technology with diverse applications that is transforming several industries. AI is the use of systems and technology to replicate human intelligence and solve common real-world issues. Machine learning (ML) and deep learning are AI technologies that use algorithms to more accurately predict occurrences without the need for human intervention. Explainable Artificial Intelligence (XAI) refers to AI that can explain decisions or forecasts to human users. XAI seeks to improve AI systems' transparency, trustworthiness, and accountability, particularly when utilized in high-risk applications such as healthcare, finance, or security. This review article provides a thorough overview …

Shared Leave Policy

Human Resources Policies

The shared leave policy enables eligible employees to donate accrued vacation leave benefits to a pool. This pool will be used to provide additional paid leave benefits to eligible employees who have experienced certain catastrophic events personally or to qualifying family members and have exhausted other sources of paid leave.

For The Purpose Of Instruction And Diversion: The Library At The South Dakota State Penitentiary, Lisa R. Lindell

Hilton M. Briggs Library Faculty Publications

The library at the South Dakota State Penitentiary in Sioux Falls played an important role within the institution’s history and can serve as a lens into wider cultural dynamics. This article examines the development of the library and how its use reflected societal perceptions of reading. In connection to the library, it explores the introduction and influence of entertainment and educational programs at the penitentiary. Many historical insights about reading at the penitentiary come from the inmates who oversaw the library. Notably, the study discloses the committed efforts of these library caretakers in advocating for the transformative power of reading. …

From Classroom To Boardroom: An In-Depth Look At Critical Thinking Amongst Accounting Students, Dorothy A. Thompson, Timothy G. Bryan

Accounting Faculty Research

The 2020 Guiding Principles and Standards of the Association to Advance Collegiate Schools of Business accreditation Standard 4.3 requires business students to be equipped with critical and analytical thinking skills. Killian (2013) states that by engaging students in a problem-based case study in an introductory-level managerial accounting course, students can acquire critical thinking skills, rather than memorize. Results from this study suggest critical thinking skills increased when it came to detecting, explaining, and defining a problem. Just as significant, critical thinking skills increase when a student encounters a problem and can solve it and make a conclusion. The paper concludes …

A Cohort Of The Willing: How Secondary Schools Might Face The Literacy Crisis, Michelle A. Barney

The Utah English Journal

Experts like Louisa Moats and anyone who has recently completed LETRS (Language Essentials for Teachers of Reading and Spelling) training, know that 95% of children can be taught to read (Louisa Moats, 2023). As a secondary educator, it’s tempting to see this statistic and ignore it. Surely, this must be someone else’s problem. In fact, if all goes according to plan in the world of elementary education, students become proficient at foundational reading skills before fourth grade, especially if one considers Kilpatrick’s work which establishes this benchmark for the development of advanced phonological awareness skills (Kilpatrick, 2015, p. …

Criminal Justice Update - February 2025, Mia Agudelo

Criminal Justice Updates

The Criminal Justice Update is a monthly newsletter created by the Adams County Bar Foundation Fellow providing updates in criminal justice policy coming from Pennsylvania's courts and legislature as well as the US Supreme Court.

Contents:

• Updates from PA Governor's Office (no updates this month)
• Updates from the PA Legislature (no updates this month)
• Updates from the Courts
• U.S. Supreme Court: Criminal Law & Procedure
• PA Supreme Court: Criminal Law & Procedure
• PA Superior Court: Criminal Law & Procedure

Woody Plant Reinvasion Shortens The Lifespan Of Grassland Restoration Treatments, Dillon T. Fogarty, Michele Beadle, Craig R. Allen, Christine Bielski, Dirac Twidwell

Biology Student Work

An important question in restoration ecology is whether restored ecological regimes are more vulnerable to transitions back to a degraded state. In woody-invaded grasslands, high-intensity fire can collapse woody plant communities and induce a shift back to a grass-dominated regime. Yet, legacies from woody-dominated regimes often persist and it remains unclear whether restored regimes are at heightened vulnerability to reinvasion. In this study, we utilize a 17-year history of fire-based restoration in Nebraska's Loess Canyons Experimental Landscape to determine whether restored grassland regimes experience faster rates of Juniperus virginiana (eastern redcedar) reinvasion compared to the initial invasion process in adjacent …

Examining Tension Management Of Coastal Residents' Decisions To Stay Or Leave During Hurricane Florence, Andrew S. Pyle, Ryan P. Fuller, Hillary Smith

Publications

This study examines how coastal residents in the path of a hurricane manage the tension to evacuate or stay. In interviews with 17 coastal residents, we found evidence of tension management through account giving. Stayers justified their choices as keeping close to loved ones and animals, reducing difficulties in returning, and benchmarking prior storms to guide their actions over other sources of information. Evacuees framed the tension as either the only choice or the better of two poor choices. Our analysis also revealed contradictions in evacuating: a case of haves (have resources to evacuate but do not) and have nots …

Recruitment And Retention In Law Enforcement, Jefferson Dennis

Master of Arts in Criminal Justice Leadership

This capstone paper covered the topic of recruitment and retention. It detailed issues around this topic and ways to improve it. United States law enforcement agencies face challenges when recruiting qualified personnel, including issues related to image, working under stress, low pay scale, and disciplined organizations. Topics were analyzed through administrative, ethical, legal, and legislative lenses. The study outlines comprehensive policy changes that include a broad and competitive pay structure, increased support to mental health workers, better community outreaches, and product modernization in recruitment and retention.

Keeping It Green Newsletter, February 2025, State University Of New York College At Cortland

Sustainability

The Keeping It Green Newsletter from the Sustainability Office, published in February 2025.

February 2025 Quicknotes, Southern Adventist University

QuickNotes – Advancement e-Newsletter

QuickNotes is an e-newsletter that comes from Advancement at Southern Adventist University. The February 2023 edition features information the ivory comb exhibit, MLK Service Day, and a new scholarship.

Magnetus: A Magnetized Plasma Research Ecosystem, N. C. Hurst, M. Abler, Michael R. Brown, J. Juno, E. G. Kostadinova, N. A. Murphy, J. Olson, D. M. Orlov, D. B. Schaeffer, D. A. Schaffner, E. E. Scime, T. M. Tenbarge, S. C. Thakur

Physics & Astronomy Faculty Works

MagNetUS is a network of scientists and research groups that coordinates and advocates for fundamental magnetized plasma research in the USA. Its primary goal is to bring together a broad community of researchers and the experimental and numerical tools they use in order to facilitate the sharing of ideas, resources and common tasks. Discussed here are the motivation and goals for this network and details of its formation, history and structure. An overview of associated experimental facilities and numerical projects is provided, along with examples of scientific topics investigated therein. Finally, a vision for the future of the organization is …

2024 Reports, Thomas Quinn Marabello, Barbara Müller, Ernie Thurston, Richard Hacken

Swiss American Historical Society Review

Business Meeting Report—September 28, 2024

President’s Report for 2024

President’s Report for 2024 for The Friends of the Swiss American Historical Society

Annual Financial Report of the SAHS

SAHS Membership Report

Publications Report

SAHS Website Report 2024

In Defense Of The Major Questions Doctrine, Louis J. Capozzi Iii

Notre Dame Law Review

The major questions doctrine, which requires agencies claiming important powers to identify clear authority from Congress, is transforming administrative law. Breaking with recent practice, the doctrine prevents the executive branch from issuing laws addressing pressing, novel issues without Congress’s affirmative consent.

In response, scholars have generally criticized the doctrine and questioned its legitimacy. Critics have alleged that the doctrine was fabricated by the Supreme Court without proper justification, is incapable of principled application, frustrates the intent of past Congresses to delegate broad power to agencies, aggrandizes judicial power, and hinders desirable executive branch lawmaking.

This Article disagrees with those criticisms …