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Models Of Judicial Interpretation: From Marshall To Kavanaugh And How The Umpire Model Changed The Game, Beau Sullivan Feb 2025

Models Of Judicial Interpretation: From Marshall To Kavanaugh And How The Umpire Model Changed The Game, Beau Sullivan

Ohio Northern University Law Review

The three predominant modes of judicial interpretation are living constitutionalism, originalism, and the umpire model. The living constitutionalist believes the Constitution is a living document that must change and adapt over time. The living constitutionalist considers the history, text, precedent, and policy when deciding a case. This is in contrast to the originalist, who considers the history and text of the document when deciding a case. The originalist favors judicial restraint and seeks to limit the role of the judge. The devotee of the umpire model champions the independent judge whose function is to the law and does not consider …


“Major Questions” Malarkey: An Arbitrary And Capricious New Doctrine For Vetoing Controversial Agency Rules, Lars Noah Feb 2025

“Major Questions” Malarkey: An Arbitrary And Capricious New Doctrine For Vetoing Controversial Agency Rules, Lars Noah

St. John's Law Review

(Excerpt)

In 2022, after years of hinting at the idea, the United States Supreme Court officially adopted the “major questions” doctrine in West Virginia v. EPA. Commentators have already spilled plenty of ink trying to make sense of what this might portend, but so far seemingly everyone has accepted at face value the Court’s framing of the issue that it confronted in that case. This essay offers a slightly different perspective on the decision and suggests that closer attention to the precise nature of the question posed therein might reveal a distinctive flaw at the heart of the majority’s newfangled …


Khartoum, Sheila Nayar Feb 2025

Khartoum, Sheila Nayar

Journal of Religion & Film

This is a film review of Khartoum (2025), directed by Anas Saeed, Rawia Alhag, Ibrahim Snoopy, Timeea M. Ahmed, and Phil Cox.


Learn By Doing: A Cure Approach To Teaching Exercise Testing And Prescription, Zakkoyya H. Lewis Feb 2025

Learn By Doing: A Cure Approach To Teaching Exercise Testing And Prescription, Zakkoyya H. Lewis

Educational Practices in Kinesiology

The purpose of this paper is to outline a course-based undergraduate research experience (CURE) for exercise testing and prescription. The CURE is a non-human research study aimed to evaluate whether readily available fitness applications (apps) follow the Frequency-Intensity- Time-Type (FITT) principle for exercise prescription. The CURE is intended to be incorporated into an in-person introductory level course over the final month of the term. Through the project, students will develop a research question and hypothesis, conduct a literature review of related research, appraise fitness apps, and congregate the results. The overall structure of the CURE is a mini-lecture from the …


Cutting Through Rocks, Sheila Nayar Feb 2025

Cutting Through Rocks, Sheila Nayar

Journal of Religion & Film

This is a film review of Cutting Through Rocks (2025), directed by Sara Khaki and Mohammadreza Eyni.


Use Of Simulation In Dietetic Internships: A Qualitative Exploration Of Program Director Attitudes And Motivations, Theresa B. O'Reilly, Amy J. Nwora, Megan Whelan, Mary-Pat Maciolek Feb 2025

Use Of Simulation In Dietetic Internships: A Qualitative Exploration Of Program Director Attitudes And Motivations, Theresa B. O'Reilly, Amy J. Nwora, Megan Whelan, Mary-Pat Maciolek

Journal of Dietetic Education

The use of simulation holds promise for the future of dietetics education for its use as an alternative for up to 30% of the 1,000 supervised practice hours for the training of Registered Dietitian Nutritionists. Even more so, simulation is a teaching tool. When done well, simulation can challenge students in a safe environment where they can receive constructive feedback from expert guides and meaningfully reflect on their learning. The purpose of this study was to interview dietetic internship (DI) program directors on their attitudes and motivations on the use of simulation in their programs, targeting the heavily program-congested states …


A Qualitative Analysis Of 14- To 17-Year-Olds’ Perceptions Of And Interest In Dietetics, Andrea Barney, Kelsey Mueller, Emily Patten Feb 2025

A Qualitative Analysis Of 14- To 17-Year-Olds’ Perceptions Of And Interest In Dietetics, Andrea Barney, Kelsey Mueller, Emily Patten

Journal of Dietetic Education

Objective: To understand 14-17-year-old youth’s perceptions of the field of dietetics and what would influence them to pursue or not pursue dietetics as a career. Design: Researchers developed an electronic survey asking about youth’s perceptions of the dietetics profession. Setting/Participants: The survey was distributed to a diverse population of youth aged 14-17 in the USA. Main Outcome Measures: Researchers aimed to understand what qualities 14-17-year-olds associate with dietetics professionals and if youth are interested in and/or view themselves as capable of becoming a dietitian. Analysis: SPSS software calculated descriptive statistics. Open-ended responses were analyzed using conventional content analysis. Results: Half …


The Usefulness Of 3d Heart Models As A Tool Of Congenital Heart Disease Education: A Narrative Review, Raghad Abdulaziz Alhojailan, Reghd Husain M Alkhalifah, Bana Albani, Majed Wadi Feb 2025

The Usefulness Of 3d Heart Models As A Tool Of Congenital Heart Disease Education: A Narrative Review, Raghad Abdulaziz Alhojailan, Reghd Husain M Alkhalifah, Bana Albani, Majed Wadi

Journal of the Saudi Heart Association

Objectives: The objective of this review is to evaluate the effectiveness of three-dimensional (3D) heart models as teaching tools for congenital heart disease (CHD), addressing the limitations of traditional medical education methods. Methods: A thorough literature review was conducted using PubMed, Google Scholar, Scientific Direct and Scopus databases. Relevant articles were screened and selected based on their discussion of the application of 3D models in CHD education. Results: The comprehensive review of 19 studies revealed that 3D heart models provide students, healthcare professionals, and patients with meaningful experiences that significantly enhance understanding and learning outcomes. These models improve …


British Latino: Investigating Discourse-Stylistic Variables And The Construction Of Persona Within Podcasting, Jonathan A. Pye Feb 2025

British Latino: Investigating Discourse-Stylistic Variables And The Construction Of Persona Within Podcasting, Jonathan A. Pye

International Journal of the Linguistic Association of the Southwest

This study expands upon previous work (McIlwaine et al., 2011; McIlwaine & Bunge, 2016) by analyzing how the Latin American community in the UK constructs identity through podcasting. The sociolinguistic construct of the persona (Campbell-Kibler, 2008; Coupland, 2007; D’Onofrio, 2020; Eckert, 2019; Podesva, 2007) is operationalized to understand how the persona of the British Latino is discursively constructed in the podcast of the British Latino Network. Using qualitative discourse analysis and values coding (Saldaña, 2013), this analysis finds that the British Latino persona is indexed in the podcast as a bricolage of four principal attributes: (1) aspirational, (2) educated, …


Murder Mystery Solved! Unmasking Multi-Generational Familial Death As A Result Of Brugada Syndrome, Ryan Tam, Sandres Aodish, Jeremiah Tom, Mohammad Jawish Feb 2025

Murder Mystery Solved! Unmasking Multi-Generational Familial Death As A Result Of Brugada Syndrome, Ryan Tam, Sandres Aodish, Jeremiah Tom, Mohammad Jawish

Advances in Clinical Medical Research and Healthcare Delivery

Brugada syndrome is an inherited condition that has an increased risk of developing ventricular arrhythmias and sudden cardiac death. This condition can be diagnosed by using the Shanghai Scoring System. Here, we present a patient with an incidental finding of Type 1 Brugada pattern on electrocardiogram amidst atypical neurological findings on presentation to the emergency department and a history of cardiac-related familial deaths of uncertain etiology.


Special Patient Populations - A Case Report Of A Jehovah’S Witness, Michael P. Mullinax, S. Jiaming Lin, Paige M. Kieper, Jake W. Vogel, Orlando Nunez Isaac Feb 2025

Special Patient Populations - A Case Report Of A Jehovah’S Witness, Michael P. Mullinax, S. Jiaming Lin, Paige M. Kieper, Jake W. Vogel, Orlando Nunez Isaac

Advances in Clinical Medical Research and Healthcare Delivery

This case report describes a Jehovah’s Witness patient with a life-threatening exacerbation of chronic anemia, warranting blood transfusion. This case highlights the complex medical management and ethical considerations encountered when treating special patient populations. Moreover, this case illustrates the delicate balance that healthcare providers must maintain when delivering necessary medical interventions to patients with competing religious beliefs.


Unilateral Hearing Loss Caused By Bilateral Otosclerosis In The Context Of Prior Viral Infection - Case Report, Ryan Tam, Michael Mullinax, Timothy Ehmann, Bryan Scott Feb 2025

Unilateral Hearing Loss Caused By Bilateral Otosclerosis In The Context Of Prior Viral Infection - Case Report, Ryan Tam, Michael Mullinax, Timothy Ehmann, Bryan Scott

Advances in Clinical Medical Research and Healthcare Delivery

This is a case report of a patient who presented with left sided hearing loss. The patient was found to have mixed conductive and sensorineural hearing loss of the left ear and restrictive hearing of the right ear. Subsequent imaging demonstrated evidence of bilateral otosclerosis. Otosclerosis is characterized by progressive pathological bone remodeling in the otic capsule, resulting in hearing loss. Given the disease burden of otosclerosis and the corresponding effects on quality of life, providers must have knowledge of the disease to incorporate it into working differential diagnoses for patients presenting with hearing loss. With increasing recognition of otosclerosis …


Interaction Personalization Based On Digital Proficiency Metrics, Usha Seetharaman Feb 2025

Interaction Personalization Based On Digital Proficiency Metrics, Usha Seetharaman

Defensive Publications Series

The variation in user skill level in interacting with software applications and devices presents a challenge in delivering user experiences that cater to diverse needs and abilities. User segmentation models that rely on metrics such as usage frequency and retention do not adequately reflect a user's actual digital proficiency. This disclosure describes a digital proficiency quotient (DPQ) that represents an individual's overall capability and comfort level within the digital realm. With user permission, DPQ is determined based on actual skill sets and behaviors based on data of user interaction with various software applications and devices. DPQ of user is used …


A Seat At The Table: Gardner-Webb Alumnus Keon Williams Jr. Opens Restaurant With A Mission, Office Of University Communications Feb 2025

A Seat At The Table: Gardner-Webb Alumnus Keon Williams Jr. Opens Restaurant With A Mission, Office Of University Communications

Gardner-Webb NewsCenter Archive

After a decade of helping his bank customers invest their money, Keon Williams Jr. decided it was time to pursue his entrepreneurial dream. The 2014 alumnus of Gardner-Webb University recently hosted the grand opening of his new restaurant, Tacos4Life, in Charlotte, N.C.


Publishing Companies: Where Is The Accountability?, Serena Roche Feb 2025

Publishing Companies: Where Is The Accountability?, Serena Roche

Cardozo Journal of Equal Rights and Social Justice (ERSJ) Blog

Over the past five decades, the consensus on best practices for effective reading instruction has gradually evolved into a debate over whether young children, in kindergarten and primary grades, learn to read more successfully through a phonics or whole language based curriculum.

This post was originally published on the Cardozo Journal of Equal Rights and Social Justice website on February 4, 2025. The original post can be accessed via the Archived Link button above.


Minutes, Faculty Research And Development Committee Meeting, Tuesday, February 4, 2025, Faculty Research And Development Committee Feb 2025

Minutes, Faculty Research And Development Committee Meeting, Tuesday, February 4, 2025, Faculty Research And Development Committee

Faculty Research and Development Committee Minutes

No abstract provided.


Usa V. Francis Garzon Feb 2025

Usa V. Francis Garzon

2025 Decisions

USDC for the District of New Jersey


Committee Motion For Disclosure Feb 2025

Committee Motion For Disclosure

Catholic Dioceses in Bankruptcy

No abstract provided.


Agricultural Drought Prediction From Multispectral Image Processing Using Deep Learning Models, Gowri L Feb 2025

Agricultural Drought Prediction From Multispectral Image Processing Using Deep Learning Models, Gowri L

Theses and Dissertations

Accurate and timely prediction of agricultural droughts is fundamental to the management of ecosystems, preservation of biodiversity, and environmental sustainability. It helps to reduce environmental exploitation, promotes eco-friendly irrigation techniques, and tackles climate change efficiently. Its social implications include food safety and financial stability through continuous rural employment. Drought prediction guarantees social progress and sustainability by ensuring zero hunger/poverty and effective water management. A multi-sensor image pre-processing framework that incorporates data from various satellite platforms like Landsat (30 metres), Sentinel-2 (10 metres, 20 metres, 30 metres), and MODIS (500 metres) is used to monitor and assess agricultural drought effectively.

Analysis …


Assessing Post-Fire Damage In Concrete Structures: A Comprehensive Review, Eneye A. Ibrahim, Dale Goff, Ali Keyvanfar, Mohammad Jonaidi Feb 2025

Assessing Post-Fire Damage In Concrete Structures: A Comprehensive Review, Eneye A. Ibrahim, Dale Goff, Ali Keyvanfar, Mohammad Jonaidi

Faculty Articles

Bridge fires present unique challenges due to their potential for catastrophic structural failures, leading to extensive traffic disruptions, economic losses, and, in some cases, loss of life. In the aftermath of a fire incident, assessing the structural integrity and future viability of concrete bridges has become a paramount concern for civil engineers and safety inspectors. The critical decision to rehabilitate or demolish a fire-damaged structure hinges on accurately assessing the extent of damage incurred. Enhancing the fire resilience of concrete structures is a critical endeavor within civil engineering, necessitating accurate evaluation methods to analyze conditions after fire exposure. Focusing on …


The Road Ahead: Emerging Therapies For Primary Iga Nephropathy, Edward J. Filippone, Rakesh Gulati, John Farber Feb 2025

The Road Ahead: Emerging Therapies For Primary Iga Nephropathy, Edward J. Filippone, Rakesh Gulati, John Farber

Division of Nephrology Faculty Papers

Primary IgA nephropathy (IgAN) is the most common form of primary glomerulopathy. A slowly progressive disease presenting in the young to middle-aged, most patients with reduced eGFR or proteinuria will progress to end-stage kidney disease (ESKD) in their lifetimes. The pathogenesis involves increased production of galactose-deficient IgA1 (Gd-IgA1) that forms immune complexes that deposit in the glomerulus, eliciting mesangial cell proliferation, inflammation, and complement activation. The backbone of therapy is supportive, including lifestyle modifications, strict blood pressure control, and renin-angiotensin system inhibition targeting proteinuria < 300 mg/day. Sodium-glucose transporter 2 inhibitors are indicated for persisting proteinuria or declining eGFR. Sparsentan is indicated for persisting proteinuria. Immunosuppression should be considered for all patients at risk for progression (persisting proteinuria and/or declining eGFR). To reduce Gd-IgA1 production, targeted-release budesonide is approved. Agents targeting B cell survival factors APRIL or BAFF/APRIL have significantly reduced Gd-IgA1 production and proteinuria in phase 2 trials but await phase 3 data for approval. To reduce inflammation, high-dose steroids are ineffective and toxic in Caucasian patients, although lower-dose regimens may be effective in Chinese patients. Complement inhibition is being actively studied. The factor B inhibitor iptacopan has conditional approval. The terminal pathway inhibitors cemdisiran and ravulizumab show promise in phase 2 studies. Our current approach for those requiring immunosuppression involves combining the reduction of Gd-IgA1 (nefecon) with suppressing the effects of inflammation (iptacopan). The optimal duration of such therapy is uncertain. Clearly, there is more to be learned with many trials underway.


The Military Order Of The Serpent And Philippine War Memory, 1904-1974, Eric Jason Kriner Feb 2025

The Military Order Of The Serpent And Philippine War Memory, 1904-1974, Eric Jason Kriner

Student Theses and Dissertations

The Military Order of the Serpent (M.O.S.) was an American anti-Filipino minstrel fraternity and veterans' organization comprised of members of the United Spanish War Veterans. To commemorate the Philippine-American War, the group dressed in Filipino blackface and paraded around the United States from 1904 to 1974. Publicly, the group’s narrative arc posited that Filipinos, by virtue of their contact with the United States Military, underwent a rapid, three-phased evolution from savage to civil. Privately, they celebrated one of the war’s atrocities, and expressed their racist hostilities and amalgamationist anxieties. During the 1920s, when Filipino emigration to the United States began …


Sustaining Diversity, Equity, And Inclusion Through Transformational Leadership In Behavioral Health Management, Ndubuisi Christopher Egunetugo Feb 2025

Sustaining Diversity, Equity, And Inclusion Through Transformational Leadership In Behavioral Health Management, Ndubuisi Christopher Egunetugo

Walden Dissertations and Doctoral Studies

This case study examines the challenges of Diversity, Equity, and Inclusion (DEI) within an organization, emphasizing systemic biases, workforce diversity, and the necessity of culturally competent care. The Behavioral Health Organization in the southern United States faces significant DEI challenges due to its diverse clientele, workforce, and various stakeholders. Transformational leadership, marked by visionary thinking and actionable initiatives, is crucial for sustaining DEI efforts and addressing disparities in service access, care quality, management practices, and treatment outcomes. The Baldrige Framework of Excellence is employed as a systematic method to embed DEI principles across organizational operations, facilitated by transformational leadership to …


Determining Spatial Responses Of Fishers (Pakania Pennanti) To Mechanical Treatments Of Forest Stands For Fuel Reduction, Tessa R. Smith, Eric M. Gese, R. David Clayton, Patricia A. Terletzky, Kathryn L. Purcell, Craig M. Thompson Feb 2025

Determining Spatial Responses Of Fishers (Pakania Pennanti) To Mechanical Treatments Of Forest Stands For Fuel Reduction, Tessa R. Smith, Eric M. Gese, R. David Clayton, Patricia A. Terletzky, Kathryn L. Purcell, Craig M. Thompson

Wildland Resources Faculty Publications

Historical forestry practices (e.g., fire suppression, heavy timber logging) have contributed to a discernable change in stand composition of western forests in the U.S., which now comprise a tinderbox mixture of increased surface and ladder fuels, dense stands, and fire-intolerant species. Forest managers are mitigating this concern by implementing silviculture practices (e.g., selective logging, thinning, prescribed burning) to reduce fuel loads and improve stand resiliency. Concern for habitat specialists, such as the fisher (Pekania pennanti), have arisen as they may be negatively influenced in the short-term by modifications to their environment that are needed to ensure long-term habitat …


State Of Utah Appellee/ Plaintiff V. Ryan Scott Hatch Appellant/Defendant : Brief Of Appellee, Utah Court Of Appeals Feb 2025

State Of Utah Appellee/ Plaintiff V. Ryan Scott Hatch Appellant/Defendant : Brief Of Appellee, Utah Court Of Appeals

Utah Court of Appeals Briefs (2020 –)

Appeal from a conviction for wanton destruction of wildlife, a third degree felony, in the Sixth Judicial District, Kane County, the Honorable Mandy Larsen presiding

SCOTT F. GARRETT, JESSICA GRIFFIN ANDERSON, Counsel for Appellant

NATALIE M. EDMUNDSON, DEREK E. BROWN, JEFFREY N. STOTT, Counsel for Appellee


Large-Bore Mechanical Thrombectomy Versus Catheter-Directed Thrombolysis In The Management Of Intermediate-Risk Pulmonary Embolism: Primary Results Of The Peerless Randomized Controlled Trial, Wissam Jaber, Carin Gonsalves, Stefan Stortecky, Samuel Horr, Orestis Pappas, Ripal Gandhi, Keith Pereira, Jay Giri, Sameer Khandhar, Khawaja Afzal Ammar, David Lasorda, Brian Stegman, Lucas Busch, David Dexter, Ezana Azene, Nikhil Daga, Fakhir Elmasri, Chandra Kunavarapu, Mark Rea, Joseph Rossi, Joseph Campbell, Jonathan Lindquist, Adam Raskin, Jason Smith, Thomas Tamlyn, Gabriel Hernandez, Parth Rali, Torrey Schmidt, Jeffrey Bruckel, Juan Camacho, Jun Li, Samy Selim, Catalin Toma, Sukhdeep Singh Basra, Brian Bergmark, Bhavraj Khalsa, David Zlotnick, Jordan Castle, David O'Connor, C. Michael Gibson Feb 2025

Large-Bore Mechanical Thrombectomy Versus Catheter-Directed Thrombolysis In The Management Of Intermediate-Risk Pulmonary Embolism: Primary Results Of The Peerless Randomized Controlled Trial, Wissam Jaber, Carin Gonsalves, Stefan Stortecky, Samuel Horr, Orestis Pappas, Ripal Gandhi, Keith Pereira, Jay Giri, Sameer Khandhar, Khawaja Afzal Ammar, David Lasorda, Brian Stegman, Lucas Busch, David Dexter, Ezana Azene, Nikhil Daga, Fakhir Elmasri, Chandra Kunavarapu, Mark Rea, Joseph Rossi, Joseph Campbell, Jonathan Lindquist, Adam Raskin, Jason Smith, Thomas Tamlyn, Gabriel Hernandez, Parth Rali, Torrey Schmidt, Jeffrey Bruckel, Juan Camacho, Jun Li, Samy Selim, Catalin Toma, Sukhdeep Singh Basra, Brian Bergmark, Bhavraj Khalsa, David Zlotnick, Jordan Castle, David O'Connor, C. Michael Gibson

Department of Radiology Faculty Papers

BACKGROUND: There are a lack of randomized controlled trial data comparing outcomes of different catheter-based interventions for intermediate-risk pulmonary embolism.

METHODS: PEERLESS is a prospective, multicenter, randomized controlled trial that enrolled 550 patients with intermediate-risk pulmonary embolism with right ventricular dilatation and additional clinical risk factors randomized 1:1 to treatment with large-bore mechanical thrombectomy (LBMT) or catheter-directed thrombolysis (CDT). The primary end point was a hierarchal win ratio composite of the following (assessed at the sooner of hospital discharge or 7 days after the procedure): (1) all-cause mortality, (2) intracranial hemorrhage, (3) major bleeding, (4) clinical deterioration and/or escalation to …


Police Culture Influence On Mental Health Of Federal Law Enforcement Officers, Ania Amat Feb 2025

Police Culture Influence On Mental Health Of Federal Law Enforcement Officers, Ania Amat

Walden Dissertations and Doctoral Studies

Occupational stressors are inherent in police work. Left unmitigated, these stressors may have deleterious effects on officers’ overall health. Police agencies throughout the country offer organizational resilience programs to aid officers navigate stressors. A constraint keeping officers from seeking mental health wellness are the unspoken social norms of police culture. Police culture stigmatizes mental health seeking behaviors, deterring officers from accessing organizational resilience programs. The purpose of this study was to understand the perceptions and lived experiences of federal law enforcement officers regarding mental health-seeking behaviors and the influence of the police culture. Study participants included 16 federal law enforcement …


Spartan Daily, February 4, 2025, San Jose State University, School Of Journalism And Mass Communications Feb 2025

Spartan Daily, February 4, 2025, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2025

Volume 164, Issue 5


The Link February 4, 2025, Access To Justice Institute Feb 2025

The Link February 4, 2025, Access To Justice Institute

The Link Newsletter

No abstract provided.


Large-Bore Mechanical Thrombectomy Versus Catheter-Directed Thrombolysis In The Management Of Intermediate-Risk Pulmonary Embolism: Primary Results Of The Peerless Randomized Controlled Trial., Wissam A Jaber, Carin F Gonsalves, Stefan Stortecky, Samuel Horr, Orestis Pappas, Ripal T Gandhi, Keith Pereira, Jay Giri, Sameer J Khandhar, Khawaja Afzal Ammar, David M Lasorda, Brian Stegman, Lucas Busch, David J Dexter, Ezana M Azene, Nikhil Daga, Fakhir Elmasri, Chandra R Kunavarapu, Mark E Rea, Joseph S Rossi, Joseph Campbell, Jonathan Lindquist, Adam Raskin, Jason C Smith, Thomas M Tamlyn, Gabriel A Hernandez, Parth Rali, Torrey R Schmidt, Jeffrey T Bruckel, Juan C Camacho, Jun Li, Samy Selim, Catalin Toma, Sukhdeep Singh Basra, Brian A Bergmark, Bhavraj Khalsa, David M Zlotnick, Jordan Castle, David J O'Connor, C Michael Gibson Feb 2025

Large-Bore Mechanical Thrombectomy Versus Catheter-Directed Thrombolysis In The Management Of Intermediate-Risk Pulmonary Embolism: Primary Results Of The Peerless Randomized Controlled Trial., Wissam A Jaber, Carin F Gonsalves, Stefan Stortecky, Samuel Horr, Orestis Pappas, Ripal T Gandhi, Keith Pereira, Jay Giri, Sameer J Khandhar, Khawaja Afzal Ammar, David M Lasorda, Brian Stegman, Lucas Busch, David J Dexter, Ezana M Azene, Nikhil Daga, Fakhir Elmasri, Chandra R Kunavarapu, Mark E Rea, Joseph S Rossi, Joseph Campbell, Jonathan Lindquist, Adam Raskin, Jason C Smith, Thomas M Tamlyn, Gabriel A Hernandez, Parth Rali, Torrey R Schmidt, Jeffrey T Bruckel, Juan C Camacho, Jun Li, Samy Selim, Catalin Toma, Sukhdeep Singh Basra, Brian A Bergmark, Bhavraj Khalsa, David M Zlotnick, Jordan Castle, David J O'Connor, C Michael Gibson

Heart and Vascular Articles

BACKGROUND: There are a lack of randomized controlled trial data comparing outcomes of different catheter-based interventions for intermediate-risk pulmonary embolism.

METHODS: PEERLESS is a prospective, multicenter, randomized controlled trial that enrolled 550 patients with intermediate-risk pulmonary embolism with right ventricular dilatation and additional clinical risk factors randomized 1:1 to treatment with large-bore mechanical thrombectomy (LBMT) or catheter-directed thrombolysis (CDT). The primary end point was a hierarchal win ratio composite of the following (assessed at the sooner of hospital discharge or 7 days after the procedure): (1) all-cause mortality, (2) intracranial hemorrhage, (3) major bleeding, (4) clinical deterioration and/or escalation to …