Digital Commons Network^™

Mapping Dna Methylation Signatures To Identify Epigenetic Variation Across Subcortical Regions Of The Human Posttraumatic Stress Disorder Brain, Hongyu Li, Yujing Liu, Yiming Shi, Jiawei Wang, Tuan P Nguyen, Yuhan Xie, Wangjie Zheng, Youshu Cheng, Dianne A Cruz, Jennifer L Modliszewski, Rosemarie Terwilliger, Alexa-Nicole Sliby, José Jaime Martínez-Magaña, Janitza L Montalvo-Ortiz, John D Roache, Lynnette A Averill, Stacey Young-Mccaughan, Paulo R Shiroma, Bertrand R Huber, David A Lewis, Jill Glausier, Paul Holtzheimer, Matthew J Friedman, Jing Zhang, Alan L Peterson, Chadi G Abdallah, Amir Valizadeh, Xinyu Zhang, Ke Xu, John H Krystal, Ronald S Duman, Hongyu Zhao, David L Corcoran, Douglas E Williamson, Matthew J Girgenti

Staff and Researcher Publications

Background: Posttraumatic stress disorder (PTSD) is a mental disorder that may occur in the aftermath of severe psychological trauma. Epigenetic changes in the brain may play a critical role in understanding the neurobiology of PTSD by linking environmental traumatic stress exposure to lasting alterations in gene expression that shape neuronal function.

Methods: We examined 1,065,750 DNA methylation (DNAm) sites from 171 donors including neurotypical controls and PTSD and major depressive disorder (MDD) cases across 6 regions implicated in the fear circuitry of the brain. We performed RNA sequencing (RNA-seq) to examine changes in gene expression and linked these changes to …

Glacier Elevation Difference Data For The Conterminous U.S., Andrew G. Fountain, Bryce Allen Glenn, Christopher Mcneil, Brian Menounos

Geology Faculty Datasets

Historic and recent elevation data for the glaciers in the conterminous US were differenced to estimate glacier mass and volume change.

Historic glacier elevations were obtained from the USGS National Elevation Dataset (https://doi.org/10.15760/geology-data.04), a digitized product from the USGS 1:24,000 paper topographic maps that included the glacier extent (Gesch, 2007). Recent glacier elevations were derived from aerial lidar and from satellite radar. The lidar data were largely obtained from the USGS 3D Elevation Program (Stoker and Miller, 2022; US Geological Survey, 2024), and filtered by acquisition date using only those data collected between mid-summer and early autumn. The …

Adlm Guidance Document On Incorporating Gender Diversity In Pathology And Laboratory Medicine, Tiffany A Thomas, Gabrielle N Winston-Mcpherson, Ina Amarillo, Alisha D Berry, Caroline J Davidge-Pitts, Sridevi Devaraj, Zil Goldstein, Brad S Karon, Brooke M Katzman, Mahmoud A Khalifa, Hung S Luu, James H Nichols, Tracy L Stockley, Michelle R Stoffel, Dina N Greene, Matthew D Krasowski

Faculty, Staff and Students Publications

Background: The first international clinical standards of care for the gender-diverse population were formulated in the late 1970s. In the last 15 years, multiple subspecialty societies within the United States have developed clinical care guidelines for those with gender dysphoria, including gender-affirming hormone therapy (GAHT) and surgical treatments. To date, there are no pathology- and laboratory medicine-specific recommendations in the United States for the gender-diverse population.

Content: This document outlines pathology- and laboratory medicine-specific recommendations for providing optimal care to the gender-diverse population, with a predominant focus on the adult population. The scope of this document focuses on the following …

Longitudinal And Cross-Sectional Evidence That Daily Resting And Activity Energy Expenditures Are Independent In Humans, Andrew K Yegian, Elizabeth Pachus, Leanne M Redman, Steven B Heymsfield, K Falkenhain, Alexandra R Harris, Shaji K Chacko, William W Wong, Daniel E Lieberman

Faculty, Staff and Students Publications

Total energy expenditure (TEE) is commonly modelled as the sum of resting energy expenditure (REE), activity energy expenditure (AEE), and diet-induced thermogenesis (DIT). This additive model has recently been challenged by the constrained energy balance model, which proposes that reductions in mass-adjusted REE compensate to some extent for increases in AEE, rendering mass-adjusted TEE effectively invariant. We tested these competing models using two complementary approaches. First, we conducted a short-term longitudinal, repeated-measures experiment in 12 adults who completed 10-day periods of high and low physical activity separated by a washout period. TEE was measured with doubly labelled water, AEE with …

Na-Gst-1 Adsorbed On Alhydrogel Co-Administered With Different Toll-Like Receptor Agonists In Hookworm-Naive Adults Using A Controlled Human Infection Model In The Usa: A Phase 2, Double-Blind, Randomised Controlled Trial, Caroline K Dirosato, Elissa M Malkin, Sean M Lee, Guacyara Erwin, Lara Hoeweler, Larissa Scholte, Maria Elena Bottazzi, David I Pritchard, Peter J Hotez, Jeffrey M Bethony, David J Diemert

Faculty, Staff and Students Publications

Background: Necator americanus glutathione S-transferase-1 (Na-GST-1) performs a crucial enzymatic step in hookworm blood feeding and is a leading target for vaccine development. Phase 1 trials in Brazil, Gabon, and the USA of recombinant Na-GST-1 adsorbed on Alhydrogel (Na-GST-1/Al), co-administered with or without AP 10-701 (Toll-like receptor [TLR] 4 agonist) or CpG 10104 (TLR9 agonist), showed the vaccine was well tolerated, safe, and immunogenic. A controlled human hookworm infection (CHHI) model was previously developed to evaluate the effect of candidate hookworm vaccines on infection. We aimed to assess the effect of vaccination with three different Na-GST-1 vaccine formulations on subsequent …

Blinded, Bias-Controlled Multi-Rater Evaluation Of Human-Versus-Ai Brain Metastasis Segmentation Using A Hybrid Foundation-Model Framework, Yiding Han, Enze Zhu, Mhd Hasan Ai Mekdash, Omar Awad, Piyush Pathak, Shixiao Liang, Daniel Allan Hamstra, Xizhe Zhang, Zaid Ali Siddiqui, Baozhou Sun

Faculty, Staff and Students Publications

Background: Accurate segmentation of brain metastases (BM) is essential for diagnosis, stereotactic radiosurgery planning, and longitudinal assessment. However, manual contouring is time-intensive, limiting clinical scalability, and exhibits substantial inter-observer variability. This variability complicates objective assessment of automated segmentation methods and challenges interpretation of model performance.

Purpose: To address these limitations, we developed TUM-SAM, a hybrid foundation-model framework for fully automated BM segmentation, and introduced a bias-controlled, blinded multi-rater evaluation paradigm to determine whether AI-based BM segmentation has reached expert-level performance and whether AI-generated contours are preferred by human experts under unbiased assessment.

Methods: TUM-SAM integrates nnU-Net-based lesion detection with a …

Fluocinolone Acetonide Implant As A Baseline Therapy For Diabetic Macular Edema: Results From The Randomized Phase 4 New Day Study, Michael A Singer, Charles C Wykoff, Christopher D Riemann, Victor H Gonzalez, Christina Y Weng, Kamel Alkhatib, Rohit A Amarshi, Scott Moody, Mary Pao

Faculty, Staff and Students Publications

Purpose: The NEW DAY (ClinicalTrials.gov identifier, NCT04469595) study assessed the efficacy and safety of the fluocinolone acetonide (FAc; 0.19 mg) intravitreal implant as baseline therapy in diabetic macular edema (DME).

Design: Prospective, randomized, single-masked, active-controlled, multicenter, 18-month, phase 4 study.

Participants: Adults with type 1 or 2 diabetes and center-involving DME confirmed by central subfield thickness (CST).

Methods: Treatment regimens were FAc implant followed by rescue supplemental injections of aflibercept if needed (2 mg/0.05 ml) for 17 months versus aflibercept loading dose (2 mg every 4 weeks for 5 consecutive doses) followed by rescue supplemental injections of aflibercept if …

Reciprocal Compensation Of Caspase-2 And P53 Regulates The Dna Damage Response In Hct116 Colon Cancer Cells, Karla E Lopez, Leslie Bandera, Luiza E Coutinho, Karen Zúñiga, Sarah Wright, Lisa Bouchier-Hayes

Faculty, Staff and Students Publications

Caspase-2 has positive and negative effects on tumor growth in different cancer models. The mechanisms determining these dual outcomes of caspase-2 activation are unclear underscoring the need to assess caspase-2 function in different cell types. We report that high caspase-2 expression is associated with lower survival in patients with colon cancer and increased tumor size in HCT116 colon cancer xenografts. We investigated the interplay between caspase-2 and p53 in regulating the proliferation of these cells. While neither of these proteins had much of an effect on cell cycle arrest on their own, deficiency in both caspase-2 and p53 led to …

Jak Inhibition In Pnpt1-Related Mitochondrial Interferonopathy: A Case Report And Review Of Mitochondrial-Immune Crosstalk, Dan Ross Brooks, Hyun Yong Koh, Taylor Martin Kerrins, Steven Lang, Emily Bland, Rui Yang, Sarah Kogan Nicholas, Stephanie Jean Sikkink, Stephen Kralik, Christine Eng, Chaya Nautiyal Murali, Seema Lalani, Pilar Lenglet Magoulas, Lisa Emrick, Kristen Sydney Fisher, Fernando Scaglia

Faculty, Staff and Students Publications

Biallelic pathogenic variants in PNPT1 cause combined oxidative phosphorylation deficiency 13 (COXPD13) (MIM #614932), linking mitochondrial dysfunction to type I interferon (IFN) activation through cytosolic leakage of mitochondrial double‐stranded RNA (mt‐dsRNA). This mechanism connects mitochondrial disease to interferonopathies such as Aicardi–Goutières syndrome (AGS). We describe a 7‐month‐old female infant with compound heterozygous PNPT1 variants presenting with severe hypotonia, feeding difficulties necessitating gastrostomy, dystonia, and elevated serum lactate. Brain magnetic resonance imaging (MRI) demonstrated marked cerebellar, brainstem, and basal ganglia atrophy, with a lactate peak on MR spectroscopy (consistent with an inverted doublet). Serum immune profiling revealed a mild but elevated …

Author Correction: Plasticity And Language In The Anaesthetized Human Hippocampus, Kalman A Katlowitz, Eric R Cole, Elizabeth A Mickiewicz, Shraddha Shah, Melissa Franch, Joshua A Adkinson, James L Belanger, Raissa K Mathura, Domokos Meszéna, Matthew Mcginley, William Muñoz, Garrett P Banks, Sydney S Cash, Chih-Wei Hsu, Angelique C Paulk, Nicole R Provenza, Andrew J Watrous, Ziv Williams, Alica M Goldman, Vaishnav Krishnan, Atul Maheshwari, Sarah R Heilbronner, Robert Kim, Nuttida Rungratsameetaweemana, Benjamin Y Hayden, Sameer A Sheth

Faculty, Staff and Students Publications

This corrects the article "Plasticity and language in the anaesthetized human hippocampus" in volume 654 on page 714.

Homework Adherence In Exposure-Based Cbt For Youth With Obsessive-Compulsive Disorder: Clinical Outcomes And Predictors Across Treatment, Abigail E Pine, Qimin Liu, Eric A Storch, Daniel A Geller, Brent J Small, Sabine Wilhelm, Joseph F Mcguire

Faculty, Staff and Students Publications

Exposure-based cognitive behavioral therapy (CBT) is the frontline treatment for pediatric obsessive-compulsive disorder (OCD), but not all youth fully respond to this treatment. While multiple factors may influence CBT response, homework adherence in CBT is a modifiable target that can improve treatment outcomes. This report examines the relationship between homework adherence and clinical outcomes in a large sample of youth with OCD who received exposure-based CBT. Here, 137 youth with OCD between 7 and 17 years old (M = 12.42, SD = 2.88) participated in a randomized controlled trial of exposure-based CBT. Homework adherence was monitored weekly, and OCD severity …

Video Games As An Advertising Media: A Comparative Analysis Between Portuguese And Spanish University Students, Alejandro Tapia-Frade, Gema Bonales-Daimiel, Belén Moreno-Albarracín

Faculty Research, Scholarly, and Creative Activity

Changes in leisure consumption are causing transformations in the relationships between young people and brands. A reflection of this is found in video games, whose predominant user profile is that of young people between 18 and 30 years old. They invest more and more time in digital universes: they play, socialize and even buy, and income from the video game sector has increased year after year in Spain and in the world, surpassing those generated jointly by cinema and music. A review of previous literature indicates the relevance as an object of study of video games that are used as …

The Impact Of Alexithymia On Body Image: The Mediating Role Of Rumination Among Students At Sultan Qaboos University, Fatima Alrahbi, Mai Helmy, Amal Alhadabi

Journal of Educational and Psychological Studies

The study aimed to examine the mediating role of rumination in the relationship between the dimensions of alexithymia and body image among first-year students at Sultan Qaboos University in the Sultanate of Oman. The descriptive method was employed, and the sample consisted of 310 male and female first-year students at Sultan Qaboos University, who were selected using a convenience sampling method. The study instruments included three scales: the Body Image Scale, the Toronto Alexithymia Scale, and the Rumination Scale. The results indicated the presence of statistically significant direct effects of the dimensions of alexithymia on rumination. The findings showed that …

Plasma And Extracellular Vesicle–Enriched Protein Profiles In Chronic Rhinosinusitis, Aryana Amin, Rutviben P. Shah Bds, Dhvani Parikh Mph, Niki Mirhosseini Bs, Baharan Fekry Phd, Donyea L. Moore, Mahboobeh Mahdavinia Md, Phd

Summer Research Program Abstracts

No abstract provided.

Cryptic Habits: The Hidden Lives Of Midsouth Entomologists. Interview With Dr. Jerome Goddard, Mississippi Public Health Entomologist And Fiction Novelist, C. J. Peterson, Jerome Goddard

Midsouth Entomologist

No abstract provided.

Subspace Decomposition For Spatial Parameter Estimation, Arthur Grik

USF Tampa Graduate Theses and Dissertations

Passive emitter localization is an important capability for wireless sensing, interference detection, and spectrum awareness. Classical timing-based localization methods estimate emitter position from differences in signal arrival time across distributed sensor platforms, but their performance depends on precise receiver synchronization and favorable signal bandwidth characteristics. This thesis investigates subspace-decomposition-based spatial parameter estimation as an alternative approach in which directional information is extracted from coherent antenna-array measurements. This work develops the theoretical foundation and signal-processing framework for angle-of-arrival estimation. Various spatial parameter estimators are presented as supporting array-processing methods before focusing on a well-known subspace-decomposition-based approach called the Multiple SIgnal Classification …

Evaluating Special Education Teachers’ Competence In Inclusive Education: A Study Of Behavior Management, Level Of Confidence, And Training Needs, Kourtney Guthrie

Electronic Theses and Dissertations

The purpose of this mixed-methods study is to examine the competence of special education teachers in rural East Texas, focusing on their experiences, perceptions, and professional development needs related to behavior management and inclusive education. Quantitative data were gathered through questionnaires given to special education teachers and elaborated upon through focus group interviews, where themes emerged. An explanatory sequential mixed-methods design was used to develop a better understanding of teachers’ preparedness and the problems involved in the implementation of inclusive practices. The findings may inform more effective teacher training, policy-making, and support systems in rural educational settings by highlighting professional …

Modern Molecular Profiling Recontextualizes The Nrg/Rtog 0539 Trial And Reveals Hidden High-Risk And Radiotherapy-Resistant Meningiomas, Leeor S Yefet, Clifford Robinson, Et Al.

2020-Current year OA Pubs

BACKGROUND: Meningiomas exhibit clinical heterogeneity. Radiotherapy (RT) remains the only adjuvant therapy, but tumor-control is variable, and biomarkers are limited. NRG/RTOG-0539 is the first prospective phase 2 trial to stratify meningioma patients for adjuvant RT based on clinical risk. Here, we apply modern molecular tools to this cohort and identify correlates of RT response.

METHODS: Tumor tissue from 100 RTOG-0539 patients was profiled using DNA methylation arrays, RNA sequencing, and whole-exome sequencing. Recurrence scores, Molecular Groups, gene expression, and copy number alterations were compared across clinical groups and between RT responders and non-responders; non-response was defined as progression or death …

Enhancing Validation Of Case-Control Omics Signatures Through "Minimalist" Single-Subject Analysis (N-Of-1 Trials): Proof Of Concept In Sepsis, Liam S Wilson, Nima Pouladi, Rachel F Nelson, Elizabeth A Middleton, Neal D Tolley, Mahdieh Shabanian, Colleen Kenost, Robert A Campbell, Matthew T Rondina, Yves A Lussier

2020-Current year OA Pubs

OBJECTIVE: To evaluate if a single-subject study (S3) design, utilizing paired transcriptome samples from the same patient (eg, "sepsis" vs "recovered"), can replicate transcriptomic signatures from small case-control studies, addressing challenges in patient accrual for rare or sub-stratified diseases.

METHODS: We generated a sepsis gene signature (SGS) comprising 300 differentially expressed genes (DEGs; FDR <  5%) from a human sepsis case-control cohort using general linear models (GLMs). Reproducibility of SGS was assessed through three approaches applied to sub-sampled independent datasets: single-subject analyses (N-of-1-MixEnrich), anticipated to perform better; conventional paired-sample GLM analyses; and a traditional case-control GLM analysis.

RESULTS: SGS reproducibility in GLM analyses was inconsistent at smaller cohort sizes (∼80% reproducibility; n = 5) but stabilized at cohort sizes >6. Remarkably, the single-subject-study approach consistently reproduced SGS in each of the 18 subjects individually (100% reproducibility; n = 1).

DISCUSSION: Conventional GLMs are …

Laser Interstitial Thermal Therapy Enhances Bidirectional Blood-Brain Barrier Permeability In Glioblastoma, Ryan T Cleary, Yiwei Fu, David Giles, Jinyun Yuan, Diogo P Moniz Garcia, Danny Palmer, Rowland H Han, Timothy Woodiwiss, Alicia B Yang, Dimitrios Mathios, Hong Chen, Albert H Kim

2020-Current year OA Pubs

BACKGROUND: Laser interstitial thermal therapy (LITT) is a minimally invasive treatment for glioblastoma that increases blood-brain barrier (BBB) permeability. However, the mechanisms and spatiotemporal features of this effect remain unclear. It is also unknown whether LITT promotes release of circulating tumor DNA (ctDNA).

METHODS: Using our previously developed LITT mouse model, we employed single-cell RNA-sequencing (scRNA-seq) to investigate gene expression changes in endothelial cells following LITT in the naive mouse brain. Brains were also harvested at multiple time points to assess LITT effects on tight junction (TJ) integrity and transcytosis via immunofluorescence and transmission electron microscopy. Human glioblastoma tissues were …

Coordinated Load-Aware Contention Domain Assignment, Peiman Amini, Navid Reyhanian, Ardalan Alizadeh, Matt Silverman

Defensive Publications Series

A system is proposed herein through which a set of techniques can be utilized to create a coordinated, latency-aware allocation policy for Dynamic Sub-band Operation (DSO).  DSO can be used to create multiple parallel contention domains.  For example, an access point (AP) can use fine-grained per-sub-band measurements, including overlapping basic service set (OBSS) frame ratio, jitter variance, airtime fairness, clear channel assessment (CCA), and retry metrics, to compute a condition score per sub-band. The AP can also use neighbor coordination pressure to prevent overlapping basic service sets (BSSs) from converging on the same sub-band and apply traffic-class-aware admission limits with …

Hierarchical Multi-Level Knowledge Graph With Compositional Contracts For Ai Agent Navigation Of Distributed Software Systems, Anonymous

Defensive Publications Series

Systems and methods store a hierarchical knowledge graph for navigating and changing distributed software systems. A product layer defines product identity, system bindings, and an end-to-end dataflow across system domains. A system knowledge graph includes a four-level specification hierarchy: domain specifications with intent phrases and ownership metadata; feature specifications with typed accepts/produces compositional contracts; behavior specifications with given/when/then invariants; and technical specifications with implementation anchors and referenced skills. An agent follows a six-phase change protocol: understand a request via semantic discovery over intent phrases, plan by traversing bindings and dataflow to identify impacted specs and code locations for approval, execute …

Confidence-Gated Hybrid Diagnosis System With Cross-System Signal Correlation For Infrastructure Failure Management, Anonymous

Defensive Publications Series

A confidence-gated hybrid diagnosis approach is disclosed for multi-system infrastructure operations. Typed signals are collected from multiple independent monitoring systems and temporally aligned within a configurable window. The aligned observations are compared to structured historical failure patterns stored in a knowledge base, where each pattern includes cross-system signal signatures and operational metadata such as recommended actions and oncall routing. A pattern match confidence is computed based on a proportion of signatures satisfied. A triage report is generated with diagnosis, confidence, affected systems, and routing. A large language model (LLM) copilot is invoked only when confidence falls below a threshold or …

Closed-Loop Profile-Guided Kernel Optimization With Bottleneck-Shift Detection And Cross-Kernel Transfer Learning, Anonymous

Defensive Publications Series

A closed-loop GPU kernel optimization technique collects hardware performance counters to form a normalized counter-profile vector and classifies the kernel into a bottleneck class. Candidate structured transforms are selected using probabilistic ranking based on stored successes and failures for transforms conditioned on bottleneck class and hardware. After each transform, the kernel is re-profiled (in addition to benchmarking), re-classified, and a bottleneck shift is detected when the bottleneck class changes. Upon a shift, remaining transforms are re-ranked for the new bottleneck class. Optimization trajectories are recorded as sequences of transforms, bottleneck-shift pairs, and speedups, enabling multi-step lookahead scoring. Cross-kernel transfer is …

Regional Shrink Testing For Empirical Capacity Validation In Distributed Computing Infrastructure, Anonymous

Defensive Publications Series

Regional Shrink Testing is disclosed for empirical capacity validation in distributed computing infrastructure. A controller configures a production region by applying safeguards such as disabling autoscaling and isolating load balancing behavior, captures baseline metrics, and iteratively reduces active service instances while maintaining substantially constant production traffic. Shrink targets may be computed proportionally per hardware type class (LSST) using resource weights, with instance selection based on priority and/or random sampling. A monitoring layer evaluates stopper metrics at a percentile across active hosts and classifies health into multiple levels to control shrinking, backoff, and peak detection based on sustained threshold durations. The …

Sram-Based Deficit Weighted Round-Robin Eligibility Maintainer With Pipelined Read-Modify-Write Forwarding, Safe Reload, And Deterministic Initialization, Anonymous

Defensive Publications Series

An SRAM-based eligibility maintainer for deficit weighted round-robin scheduling stores per-queue quantum and credit in packed SRAM entries. A fixed-latency pipeline accepts multiple opcodes including CSR read, CSR write, credit decrement, and credit increment, aligned to SRAM read latency. Read-after-write correctness is provided using address-collision forwarding of in-flight write data. Per-queue eligibility is tracked in a first register vector and reload selection is tracked in a second vector indicating whether a next credit operation should reload relative to quantum. Credit updates use saturating arithmetic and threshold-aware eligibility comparisons with selectable semantics. Deterministic initialization paints SRAM with known data while defining …

Systems And Methods For Automated Recipe Extraction From Multimedia Content With Visual Pantry Inventory Detection And Differential Shopping List Generation, Anonymous

Defensive Publications Series

Systems and methods are described for transforming unstructured cooking-related multimedia into actionable outputs. A client provides a video link, web link, screenshot, or photo. One or more models extract ingredients and preparation actions using combinations of speech recognition, optical character recognition, and visual recognition. A structured recipe is generated with ingredients and ordered steps, and additional attributes such as serving size, nutrition or macronutrients, and dietary tags are derived. A meal plan may be produced over a time window, and required ingredients are aggregated. Optionally, the user captures images of pantry and/or refrigerator contents via a guided flow. Inventory items …

Autonomous Multi-Agent System For Social Discovery And Interpersonal Compatibility Evaluation, Anonymous

Defensive Publications Series

Autonomous agent-mediated social discovery is disclosed. Users configure personalized AI agents with personality models, tiered values hierarchies, and conversational behavior parameters. Agents publish anonymized personality embeddings to a discovery service that performs compatibility pre-filtering and a handshake protocol to initiate contact. Matched agents conduct a structured, multi-stage, multi-turn compatibility conversation managed by a conversation orchestrator, with optional early termination based on non-negotiable value misalignment. A compatibility scoring engine generates a multi-dimensional compatibility report derived from conversation signals, including sub-scores for personality alignment, values congruence, and behavioral compatibility. A human supervisory interface enables observation of agent-to-agent interactions, private guidance injection invisible …

Agent Preference Memory Integrity Verification System For Detecting And Recovering From Preference Poisoning Attacks, Anonymous

Defensive Publications Series

Systems and methods are described for integrity verification of AI agent preference memory. Preference entries include semantic content, confidence, timestamp, source interaction identifier, and reinforcement history, and are associated with cryptographic provenance signatures and interaction context hashes. A preference consistency graph computes embedding-based consistency weights between preferences and produces anomaly scores for candidate preferences based on contradictions with stored high-confidence preferences. Confidence values may decay over time and be re-verified using subsequent behavior and a multi-source corroboration ladder. The system creates cryptographically signed checkpoints and performs targeted rollback to surgically remove unverifiable or anomalous preference entries while preserving verified entries, …

Cascading Proxy Drift Detection And Corrective Action System For Multi-Layer Optimization Pipelines, Anonymous

Defensive Publications Series

Systems and methods are described for detecting and correcting cascading proxy drift in multi-layer optimization pipelines. A directed acyclic graph represents proxy metrics across layers, including a ground-truth metric and downstream proxies. For each adjacent layer pair, a drift state is computed using sliding-window Spearman correlation, a trend estimate, and volatility, with adaptive window sizing via change-point detection. Cascade onset is detected based on a product of per-layer correlations and/or concurrent negative drift across multiple layers. Upon cascade detection, a drift source is localized using intervention-based tests including sequential freeze, counterfactual correlation estimation, and Shapley-value attribution (optionally via permutation sampling). …