Digital Commons Network^™

Homocysteine Thiolactone From Translation Proofreading Is An Endogenous Ligand For Cell-Cell Signaling By The Receptor Sdia, Lorenzo Eugenio Leiva, Roberto A. Zúñiga, Gregory J. Phillips, Michael Ibba

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Several widespread mechanisms enable cellular communication and coordinate the behavior of bacterial populations. The modules responsible for cellular communication are often found in matching pairs: an enzyme that synthesizes a signal molecule and a specific receptor that decodes it. A notable exception is Escherichia coli SdiA, a homolog of known N-acyl-homoserine lactone (AHL) receptors, for which no corresponding AHL synthase exists. SdiA is an orphan receptor that enables cross-talk by sensing AHLs from other bacterial species. In this work, we investigated whether homocysteine thiolactone (HTL), an AHL-like molecule arising from a proofreading reaction of methionyl tRNA synthetase (MetRS) to correct …

Health Disparities, Early Intervention, And Neurodevelopmental Outcomes In Preterm Infants, Samantha Dora Pescatore

ETD Collection

Preterm infants are at a higher risk for a variety of health complications due to their underdeveloped organ systems and neurological systems. While the survival of preterm infants has greatly improved due to the advances of modern medicine, these infants are at increased risk for neurodevelopmental delays when compared to full term infants due to risk factors that accompany preterm birth, such as low birth weight, brain immaturity, nutritional challenges, and more (Behrman & Butler., 2007; Chung et al., 2020; Rubens et al., 2014; Song, I. G., 2022;). Research suggests that early intervention services can influence the development, health, education, …

A Late Holocene (Late Bronze Age) Record Of The Syrian Elephant (Elephas Maximus Asurus) From Gavur Lake Swamp (Kahramanmaraş, Türkiye), Serdar Mayda, Yarenkür Alkan

Turkish Journal of Earth Sciences

The Syrian elephant (Elephas maximus asurus Deraniyagala, 1951) constitutes the extinct westernmost population of the Asian elephant and occupied parts of the Near East until the early first millennium BCE. Although historical, iconographic, and dental evidence for this population has been discussed extensively, its postcranial anatomy remains poorly documented. We present a revised osteological and morphometric study of cranial and postcranial remains recovered from the Late Bronze Age Gavur Lake Swamp assemblage (ca. 1650–1400 cal BCE) in Kahramanmaraş, southeastern Türkiye, during rescue excavations conducted in 2021 and 2022. The material derives from a natural swamp deposit rather than from an …

Resource Assessment Report 9: South Coast Crustacean Resource 2045-25 Assessment, Emma-Jade Tuffley, Simon De Lestang

Resource Assessment Reports

The South Coast Crustacean Resource (SCCR) comprises southern rock lobster (Jasus edwardsii), western rock lobster (Panulirus cygnus), crystal crab (Chaceon albus), giant crab (Pseudocarcinus gigas), and champagne crab (Hypothalassia acerba). The resource is accessed primarily by the South Coast Crustacean Managed Fishery (SCCMF), which operates between Augusta in the west and the South Australian border in the east. Since the 2022–23 season, the SCCMF has been managed under an Individual Transferable Quota (ITQ) system with Total Allowable Commercial Catches (TACs) set for four quota zones. Recreational fishing retains a small quantity of rock lobster only.

During the 2024–25 fishing season, …

Assessing Current Non-Pharmacologic Pain Management Practices For Sickle Cell Disease In Adults, Shreya Kolipaka, Michelle Axe, Charmaine Wright, Stephanie Guarino

Student Papers, Posters & Projects

OBJECTIVES: Both acute and chronic pain caused by sickle cell disease (SCD) is often managed with opioid therapy despite limited evidence for long-term efficacy. Adequately managing SCD pain requires a comprehensive approach, incorporating both pharmacologic and non-pharmacologic interventions. In other conditions, peer-mentored group programs are effective in managing chronic pain; however, their role in SCD is not yet described. Our objective is to understand patients' current pharmacologic and non-pharmacologic SCD management practices as well as further exploring perspectives of pain related to SCD.

METHODS: Participants were interviewed using semi-structured format. Audio-recorded interviews were transcribed. Descriptive statistics and pain management modality …

Palatal Expansion Using The Invisalign Palatal Expander, Hassan Chihab

ETDs from 2020-2029

Palatal expansion has been used in orthodontics to treat a narrow maxilla and to primarily correct posterior dental crossbites. In younger patients, palatal expansion can readily be achieved through opening of the mid-palatal suture, as it is not fused at that age. As the mid-palatal suture matures, expansion will gradually be difficult to achieve, and more dental expansion is obtained rather than skeletal. In addition, there is a tendency to get more dental tipping. Palatal expansion has been recommended not only to correct crossbites but also to improve breathing in patients with sleep disorders such as obstructive sleep apnea (OSA). …

In Re: Raphael Ross

2026 Decisions

USDC for the Eastern District of Pennsylvania

Integrated Edge Detection Of Gravity Data And Seismicity Approach For Mapping Potential Faults In The Bolu Region, Hazel Deni̇z Toktay, Burçi̇n Di̇dem Tamtaş

Turkish Journal of Earth Sciences

The Bolu region, situated along the western–central segment of the North Anatolian Fault Zone (NAFZ), is characterized by a complex fault architecture in which multiple overlapping strike-slip segments and associated subsurface structures accommodate active crustal deformation. Although the principal fault strands of the NAFZ have been well mapped, several clusters of seismicity are observed in areas without clear surface fault expression, indicating the presence of subsurface or poorly expressed fault zones. In this study, we integrated edge detection methods with a seismicity approach to delineate active and buried structural features across the Bolu region. Bouguer gravity anomalies derived from the …

Modern Economic Analysis And Antitrust Law: A Guide, Steven C. Salop

Georgetown Law Faculty Publications and Other Works

This book presents a modern economics approach to antitrust law. It expands upon and supplements traditional legal analysis of antitrust law and policy. It does so by analyzing antitrust legal standards and case law through the lenses of industrial organization economics and decision theory. The work is intended to be a comprehensive introductory guide for students, practitioners, and anyone else interested in learning the core of modern antitrust economics. Understanding the economics of antitrust and decision theory and applying that reasoning to specific cases and issues are critical steps for successfully studying and practicing antitrust law and policy. It treats …

The Algorithmic Collusion Problem: A Judicial Framework For Analyzing Algorithms Under § 1 Of The Sherman Act, Rix Ryskamp

Washington Journal of Law, Technology & Arts

Courts are increasingly seeing Sherman Act Section 1 claims that involve AI and other software algorithms at the center of alleged conspiracies to unreasonably restrain trade—often called algorithmic collusion claims. Adjudicating these claims can involve complex analyses of how algorithms interact with alleged conspiracies. However, most of the Section 1 case law stems from traditional agreements and can be hard to apply to algorithmic collusion scenarios. This Article provides a framework that judges and other adjudicators might use to analyze the role of an algorithm in an alleged conspiracy without becoming bogged down in technical details early in the case. …

Pacific Rxtracts - July 2026, Pacific Rxtracts

Pacific RxTracts

Articles:

• Tribute: In Memory of Evan Le
• Redefining Influenza Prevention: Phase 3 Trial of an mRNA Influenza Vaccine
• Risk of Non-Vitamin K Anticoagulants in Atrial Fibrillation
• Oral Semaglutide and Cardiovascular Risk: Expanding Its Role in High-Risk Patients
• Baxdrostat for Resistant Hypertension: The Bax24 Phase 3 Trial
• SGLT2 Inhibitors Shown to Normalize Blood Pressure in Patients with Type 2 Diabetes
• Brolucizumab: A New Vision for Treating Proliferative Diabetic Retinopathy
• Mavacamten Comes of Age: FDA Expands Treatment Options for Adolescent Hypertrophic Cardiomyopathy
• Children and Adolescent CKD Management: New Evidence Supports RAAS Inhibitors as First-Line Therapy
• Comparing Survival Outcomes of CDK4/6 Inhibitors plus …

From Automation To Adjudication: Evaluating The Role Of Artificial Intelligence In Dispute Settlement, Karem Sayed Aboelazm, Muayad Ahmad Obeidat, Raghda Raafat, Nada Zuhair Alfil, Fady Tawakol

All Works

This paper explores the evolving transition from automation to adjudication by examining the role of artificial intelligence (AI) in dispute settlement processes. It assesses how AI can enhance procedural efficiency, support judicial reasoning, and improve access to justice. Adopting a qualitative and interpretive approach, the study analyzes academic scholarship, policy frameworks, and comparative international practices to understand the integration of AI within judicial and quasi-judicial settings (Abedi et al., 2025). The findings suggest that while AI significantly improves administrative processes and provides valuable decision-support tools, it also raises critical concerns regarding algorithmic bias, lack of transparency, and the risk of …

Anthony Dowell V. Laurel Harry

2026 Decisions

USDC for the Middle District of Pennsylvania

Icon Psg 1 Fl Llc V. Jenkins Court Realty Co Lp

2026 Decisions

USDC for the Eastern District of Pennsylvania

Hudson Hospital Opco Llc V. Cigna Health And Life Insurance Co

2026 Decisions

USDC for the District of New Jersey

Bridge Scour Analysis For Rocks: Classification, Method Selection, And Practical Case Studies, Darud E. Sheefa, Stanley Vitton, Zhen (Leo) Liu, Brian Barkdoll

Michigan Tech Publications

Despite the availability of several scour calculation methods, bridge scour analysis for scour susceptible rocks is much less understood than its counterpart for sands, because scour calculation equations were traditionally obtained using flume tests with sands. As a result, there are three major knowledge gaps in the bridge scour analysis for susceptible rocks: (1) a rock classification system is needed for scour considerations to serve as a pre-screening process before conventional scour analysis involving sampling, erodibility testing, and scour calculation, (2) there has been a lack of information to guide the scour analysis for rocks including detailed procedures, needed and …

Staff Education To Decrease Workplace Violence Through De-Escalation Training In The Emergency Department, Tyrani Anderson

Walden Dissertations and Doctoral Studies

Workplace violence remains a significant issue in healthcare settings, particularly in emergency departments where psychiatric patients may present with aggressive behaviors. Nurses and healthcare staff are frequently exposed to verbal threats, intimidation, and physical aggression, which negatively impact staff safety, job satisfaction, and patient care quality. Despite workplace violence prevention policies, gaps remain in staff preparedness when managing escalating patient behaviors. The purpose of this Doctor of Nursing Practice project was to implement an evidence-based de-escalation training program to improve staff knowledge about managing aggressive psychiatric patients in the emergency department. The practice- focused question was: Can staff education on …

Stephen Brown V. Delaware County Sheriffs Department

2026 Decisions

USDC for the Eastern District of Pennsylvania

George Arsenis V. Blue Foundry Bancorp

2026 Decisions

USDC for the District of New Jersey

Examination Of Maternal Mortality, Mental Health Conditions, And Co-Occurring Factors, Laura Eileen Skaarer

Walden Dissertations and Doctoral Studies

Maternal mortality (MM) continues to be a public health concern in the state of Arizona. There is little to no research investigating the relationship between MM and mental health conditions co-occurring with contributing factors among women who have died in Arizona while pregnant or within 1 year of the end of a pregnancy. The purposes of this quantitative study, guided by the three delays model (3DM), were to examine (a) MM and mental health conditions as the primary underlying cause of death; (b) MM and mental health conditions surrounding death; and (c) significant contributing factors (i.e., discrimination, knowledge, lack of …

Generative Ai In The Online Classroom: Lessons From A Plant Physiology Course, Dan Ye, Svoboda V. Pennisi, David Jespersen, Christy Rich

Michigan Tech Publications

Although the adoption of generative artificial intelligence (GenAI) in higher education is a reality, we are still in the early days of understanding how it can be used and applied in educational contexts. A significant gap remains in understanding its impacts within plant sciences, and in horticulture in particular. More research is needed to understand the overall impact of artificial intelligence on learning and teaching from educational perspectives, and to investigate how to integrate GenAI tools in education to ensure technology affects teaching and learning in a meaningful way on a broader scale. We investigated university students’ perceptions and uses …

How Children Recognize Emotions: Familiarity, Emotional Information Processing, And Autism Spectrum Disorder, Katy Wagner Brooks

Electronic Theses and Dissertations 2020 - Present

The ability to identify facial emotional cues is an important nonverbal communicative skill that may be impaired in individuals with Autism Spectrum Disorder (ASD), although prior research has produced inconsistent findings regarding the nature and extent of these impairments. The present study examined facial emotion recognition (FER) abilities in 105 children aged 3 to 8 years, including 32 children with ASD and 73 typically developing (TD) children. Relationships between FER performance and resting-state electroencephalographic (EEG) activity were explored in a smaller subsample. The study investigated effects of emotion type, facial familiarity, emotional intensity, and stimulus presentation format (dynamic versus static) …

Portrait: A Calibrated Patient ‘Passport’ With Built-In Refusal - Describing Individuals Against A Reference Population, Daniela Oehring

School of Health Professions

Background Average-based summaries serve individual patients poorly. PORTRAIT is a calibrated, abstention-aware tool that describes where one patient sits relative to a reference population across 12 cardiometabolic markers, how confident that placement is, and which features drive it. PORTRAIT describes; it does not diagnose or predict. Abstention is a designed feature given the known limits of conditional coverage.Methods Conformal calibration was combined with distribution-free coverage bounds, quantile-regression coordinates, and copula-based joint structure. A frozen reference cohort (n=9421) supplied fixed calibration; a held-out cohort (n=2247) tested transportability across six strata. A release gate required the minimum per-slice coverage to hold across …

Property Tables For Thermally Perfect Gases At Low Pressure, Travis J. Moore, Matthew R. Jones

Faculty Publications

Tables giving gas properties at low pressure enable the efficient analysis of processes in which the gas is approximated as thermally perfect but not calorically perfect. In addition to specific enthalpy and specific internal energy, thermally perfect gas tables include special functions that depend only on temperature—relative pressure and relative specific volume. These functions may be used to determine pressure, volume, and temperature of thermally perfect gases undergoing hypothetical isentropic processes. However, the definitions of these functions included in widely used thermodynamics textbooks are vague, inconsistent, or incorrect. The intent of this work is to discuss common inaccuracies in the …

"Todo: Fix The Mess Gemini Created": Towards Understanding Genai-Induced Self-Admitted Technical Debt, Abdullah Al Mujahid, Mia Mohammad Imran

Computer Science Faculty Research & Creative Works

As large language models (LLMs) such as ChatGPT, Copilot, Claude, and Gemini become integrated into software development workflows, developers increasingly leave traces of AI involvement in their code comments. Among these, some comments explicitly acknowledge both the use of generative AI and the presence of technical shortcomings. Analyzing 6,540 LLM-referencing code comments from public Python and JavaScript-based GitHub repositories (November 2022-July 2025), we identified 81 that also self-admit technical debt (SATD). Developers most often describe postponed testing, incomplete adaptation, and limited understanding of AI-generated code, suggesting that AI assistance affects both when and why technical debt emerges. We term GenAI-Induced …

Epilepsy-Associated Digenic Variants Affecting An Actin-Mitochondria-Glutamate Pathway Promote Seizure Susceptibility, Shenzhao Lu, Mengqi Ma, Shabab B Hannan, Mingxi Deng, Hu Chen, Zhijian Yu, Lindsey D Goodman, Haein Kim, Yun Zhao, Sandeep Kumar Dubey, Wen-Wen Lin, Xueyang Pan, Debdeep Dutta, Vishnu Anand Cuddapah, Jill A Rosenfeld, Xi Luo, Zhandong Liu, Joshua M Shulman, Hugo J Bellen

Faculty, Staff and Students Publications

Epilepsy affects approximately 50 million people worldwide, yet more than half of individuals with a presumed genetic cause still lack a molecular diagnosis despite the identification of over 1,000 monogenic epilepsy genes. This diagnostic gap is unlikely to be resolved by improved variant detection alone, suggesting that variants affecting the same biological pathway may combine to cause disease. By studying epilepsy-associated actin regulatory genes, we identified a conserved "actin-mitochondria-glutamate (AMG) pathway". We demonstrate that reduced actin polymerization promotes DRP1-mediated mitochondrial fission, increases reactive oxygen species (ROS) levels, and enhances glutamatergic transmission, leading to seizures. The glial innate immune pathway, a …

Impostor Syndrome In The Ranks: Understanding Self-Doubt To Improve Leader Performance, Joel Kotanko

USF Tampa Graduate Theses and Dissertations

Impostor syndrome (IS) — the persistent pattern of self-doubt in which capable individuals fear being exposed as frauds despite objective evidence of competence — has been studied extensively in academic, healthcare, and corporate populations, where it is generally treated as detrimental to professional performance. Little empirical work has examined IS in U.S. military officers, a population operating under structural conditions the literature identifies as primary amplifiers of fraudulence perceptions: high-stakes permanent evaluations, up-or-out promotion systems, cultural pressure against outward expressions of doubt, and recurring role transitions under compressed timelines. This dissertation provides the first quantitative investigation of the relationship between …

Sober Curiosity Among Lgbtq+ Women And Non-Binary People In Aotearoa New Zealand, Tonda L. Hughes, Jillian R. Scheer, Lauren Bochicchio, Laurie A. Drabble, Carol Emslie, David Whiteley, Belinda Lunnay, Paul R. Ward, Antonia C. Lyons

Faculty Research, Scholarly, and Creative Activity

Background: Although global drinking rates are declining, this trend is less evident among women, with LGBTQ+ women and nonbinary people at elevated risk for hazardous drinking. In addition to minority stress (e.g., stigma, discrimination), drinking culture and social norms likely shape alcohol use within these groups, yet remain underexplored as potential intervention points. Objective: This study was part of a larger multi-country project on alcohol use among LGBTQ+ women and nonbinary individuals. Because online resources have been found to appeal to stigmatized groups, we aimed to examine LGBTQ+ women’s and nonbinary people’s experiences with alcohol use in Aotearoa New Zealand, …

From Shortage To Strategy: Optimizing Scarce Resource Allocation In Healthcare, Daniela Duran Cantarino

USF Tampa Graduate Theses and Dissertations

The allocation of scarce medical resources presents one of the most consequential challenges in health care, requiring decisions that balance equity and efficiency under pervasive uncertainty. This dissertation develops optimization-based frameworks for two critical domains, organ transplantation and emergency medical services, and demonstrates how operations research methods can improve upon current practice along both dimensions simultaneously.

In the domain of deceased-donor kidney allocation, two complementary frameworks are proposed. The first is a bi-objective stochastic optimization model that jointly maximizes post-transplant survival (efficiency) and prioritizes candidates with the highest pre-transplant mortality risk (equity), subject to regional chance constraints on graft failure …

Va Dent J October, November And December 2011

Virginia Dental Journal

No abstract provided.