Digital Commons Network^™

A Multi-Site Study Of Clinician Perspectives In The Lifecycle Of An Algorithmic Risk Prediction Tool, Rita Dexter, Kristin Kostick-Quenet, Jennifer Blumenthal-Barby

Center for Medical Ethics and Health Policy Staff Publications

Recent advancements in the performative capacities of artificial intelligence (AI), machine learning (ML), and algorithmic-based tools open up numerous applications in modern medicine. There are, however, few studies that track the whole lifecycle of a digital healthcare tool as it evolves from conception, to design, and deployment in real world settings-especially with a focus on the social dynamics amongst the end-users of the tool: clinicians. In this paper, we present data from a multi-site, 5-year study focused on the development and deployment of an algorithmic risk calculator (HeartMate 3 Risk Score) into a validated and efficacy tested clinical decision support …

An Ethnomusicological Approach To Culture In Culturally Relevant Pedagogies And Curricula, Andrés R. Amado

School of Music Faculty Publications

Although the frameworks of Culturally Relevant Pedagogy, Culturally Responsive Teaching, and Culturally Responsive Curriculum tend to reduce educational disparities, pedagogical approaches focused on minoritized populations now draw controversy. This chapter exam ines the essentializing potential of historical notions of “culture” used in these frameworks and proposes instead an ethnomusicological definition that conceives culture as a malleable collection of habits shared by different individuals and groups. This definition avoids equating culture with specific traits of minoritized people and helps valorize collaborative teaching and learning. After situating Culturally Relevant Pedagogy within the intellectual history of “culture,” and overviewing the field of ethnomusicology …

Tort Law Heterodoxy In China, Benjamin L. Liebman, Rachel E. Stern, Eva Wenwa Gao, Xiaohan Wu

Faculty Scholarship

Chinese courts routinely ask defendants to pay damages without evidence of negligence while relying on concepts such as fairness, substantive justice, or discretion. This chapter examines how Chinese courts arrive at decisions that feel fair or just in cases where they refer to those ideas. Analysis of a dataset of 10,000 judicial decisions in personal injury cases suggests that Chinese courts refer to these concepts when they impose liability on two types of parties: (1) participants in a shared activity and (2) those who control a physical space. By assigning legal responsibility in these cases, Chinese courts acknowledge traumatic harm, …

Graphage: Unleashing The Power Of Graph Neural Network To Decode Epigenetic Aging, Saleh Sakib Ahmed, Nahian Shabab, Abul Hassan Samee, M Sohel Rahman

Faculty, Staff and Students Publications

DNA methylation is a crucial epigenetic marker used in various clocks to predict epigenetic age. However, many existing clocks fail to account for crucial information about CpG sites and their interrelationships, such as co-methylation patterns. We present a novel approach to represent methylation data as a graph, using methylation values and relevant information about CpG sites as nodes, and relationships like co-methylation, same gene, and same chromosome as edges. We then use a graph neural network (GNN) to predict age. Thus our model, GraphAge leverages both the structural and positional information for prediction as well as better interpretation. Although, we …

Corrigendum To “Neuro-Ophthalmic Complications Following Eighth Cranial Nerve Microvascular Decompression” [Am J Ophthalmol Case Rep (2025) Ecollection 1–3 102258], Stanley M Saju, Patrick J Hunt, Pamela Davila-Siliezar, Noor Laylani, Andrew G Lee

Faculty, Staff and Students Publications

This corrects the article "Neuro-ophthalmic complications following eighth cranial nerve microvascularx decompression" in volume 37, 102258.

Impact Of Length Of Stay On Diagnostic Yield In The Epilepsy Monitoring Unit: A Multi-Center Retrospective 12-Year Veterans Health Administration Study, Maximillian S Feygin, Autumn Smith, Sruthi Gopinath Karicheri, Khadar Haroun, Omar Khan, Maria R Lopez, Stephan Eisenschenk, John Jones, Stephanie Reeder, Alan R Towne, Christopher Ransom, Karen Medin, James Chen, Tung Tran, Nina I Garga, Noemi Rincon-Flores, Marissa Kellogg, Steven Tobochnik, Zulfi Haneef

Faculty, Staff and Students Publications

Objective: Epilepsy Monitoring Units (EMUs) in Veterans Health Administration (VHA) Epilepsy Centers of Excellence (ECoE) are critical for the diagnosis and management of seizure disorders. Whether a shorter length of stay (LOS) in the EMU due to scheduling impacts diagnostic yield is unclear.

Methods: Data from 7074 EMU visits across 15 VHA EMUs (2012-2024) were analyzed. Based on usual admission schedules, EMUs were divided into "fixed" (typically Monday-Friday) or "flexible" subgroups. Diagnostic outcomes were classified as epileptic seizures (ES), psychogenic non-epileptic seizures (PNES), other non-epileptic events, and inconclusive. Diagnostic rates were compared between fixed and flexible sites using cumulative distribution …

Functional Mobility And Pain Are Improved For 6 Years After Adolescent Bariatric Surgery, Neil Thivalapill, Todd M Jenkins, Thomas H Inge, Changchun Xie, Anita P Courcoulas, Carroll M Harmon, Michael A Helmrath, Stephanie Sisley, Marc P Michalsky, Justin R Ryder, Teen‐Longitudinal Assessment Of Bariatric Surgery (Teen‐Labs) Consortium

Faculty, Staff and Students Publications

Objective: The long-term durability of improvements in functional mobility and musculoskeletal pain for adolescents after metabolic and bariatric surgery (MBS) is unknown.

Methods: We used the Teen-Longitudinal Assessment of Bariatric Surgery (Teen-LABS) study to determine the change in mobility and pain among adolescents who underwent MBS. From standardized 400-m walk tests, we analyzed walk time, heart rate (HR) parameters, and musculoskeletal pain.

Results: The mean walk time improved from 383 s (95% CI: 368-399) prior to surgery to 351 s (95% CI: 330-372) by 6 years. The mean resting HR was 90 beats per minute (bpm; 95% CI: 87-93) preoperatively …

Empowering Educational Leaders: Enhancing Administrative Leaders’ Effectiveness Through Strategic Professional Development, Elizabeth Reed

Dissertations

This study analyzed the current state of professional development opportunities for administrative leaders across ten U.S. states. The research aimed to explore trends, perceived needs, and gaps in professional learning programs for educational administrators. The central research question guiding this study asked: How do administrative leaders perceive and experience existing professional development opportunities, and what areas require strategic improvement? A mixed methods approach was used, with survey data collected from administrative leaders serving in K–12 school settings. The survey instrument was designed to assess participants' perceptions of the relevance, effectiveness, and accessibility of their current professional development experiences. Data analysis …

Effective And Empowering Psychotherapy For Black Women: A Culturally Adapted Proposed Model, Kaylla A. Jackson

Dissertations

Black women in the United States are a minoritized group that has experienced oppression and suffering explicitly targeting their intersectional and minority identities. The intensity and frequency of stressors result in a negative impact on Black women that prompts a need to cope. Rather than relying on professional mental health care, many Black women rely on their religious and spiritual communities and other cultural and historical methods to cope with stressors. As a field and profession, clinical psychology has been overwhelmingly dominated by White individuals. The profession has a rich history of developing and perpetuating oppressive systems that have ignored …

Understanding The Afghan Newcomer Experience From The Perspectives Of Teachers And Students, Elisabeth C. Trost

Dissertations

Newcomer English learners (ELs) often arrive in the United States having fled persecution, economic or political oppression, war, or natural disasters in their country of origin. They are new to the English language, new to the American school system, at times well into their educational journey, and sometimes have missed out on significant amounts of formal schooling. Many also carry trauma from the circumstances that forced them to leave their homes. Most schools are not fully equipped to welcome these students and their families into the learning community, nor are they prepared to address the unique challenges newcomer ELs face. …

Bridging The Gap: Exploring The Intersection Of Formal Mental Health Services And Informal Social Supports In Bipoc Communities, Patrice D. Patton-Campbell

Dissertations

Despite growing awareness of mental health disparities, BIPOC (Black, Indigenous, and People of Color) communities continue to face significant barriers in accessing culturally responsive mental health care. This dissertation explores the intersection between formal mental health services and informal social supports such as family, religious institutions, and community networks to understand which systems are more trusted, accessible, and effective for BIPOC individuals. Grounded in Urban Liberation Psychology and guided by decolonial and culturally responsive care frameworks, this qualitative study draws from focus groups and interviews with 33 participants, including both community members and service providers from the Chicagoland area and …

The Premature Loss Of The Black Male And Its Implications On The Black Family System And Community: A Proposed 12-Step Grief Support Group Model, Alicia Smith

Dissertations

Premature deaths, ages 15–44, and loss of Black males through homicide, along with suicide and systemic violence, and incarceration, create lifelong emotional and psychological trauma for those who remain behind in Black family settings and society. U.S. social injustices against Black communities and multigenerational losses and racial harm create specific population-based challenges, such as questioning care, lack of accessibility to competent resources, and Black identity issues, which traditional grief recovery programs struggle to help adequately. Even though approaches such as cognitive-behavioral therapy, complicated grief treatment, present-centered therapy, trauma-focused therapy, including eye movement desensitization and reprocessing (EMDR) therapy, and forgiveness therapy …

Polyclonal Plasma Cell (Polypc) Signature As A Key Indicator For Predicting The Progression Of Mgus To Multiple Myeloma, Fumou Sun, Yan Cheng, Catherine Ma, Hongwei Xu, Clyde Bailey, David Mery, Timothy Cody Ashby, Daisy Alapat, Yong Li, Ken H Young, Samer Al Hadidi, Sharmilan Thanendrarajan, Carolina Schinke, Maurizio Zangari, Frits Van Rhee, Guido Tricot, John D Shaughnessy, Fenghuang Zhan

Faculty, Staff and Students Publications

Background

Multiple myeloma (MM) is virtually always preceded by monoclonal gammopathy of undetermined significance (MGUS). Elevated serum markers are used to classify MGUS patients into clinical risk categories. Previous research has indicated that the absence of a normal plasma cell signature in MGUS is linked to early progression.

Objective

To confirm that the presence of a “polyclonal plasma cell (PolyPC) signature” serves as a robust negative predictor of MGUS progression.

Methods

374 MGUS patients were enrolled, including 334 patients with stable disease and 40 patients who progressed to MM within 10 years. An oligonucleotide microarray analysis was performed on mRNA …

Power Asymmetry Dynamics: Assessing Interdependence In France-Cameroon Relations Through Economic And Security Cooperation (2000–2024), Chick Edmond

Political Science & Geography Faculty Publications

This paper examines the dynamics of power asymmetry in the interdependent relationship between Cameroon and France from 2000 – 2024 with a focus on security and economic cooperation. The main research question asks: To what extent has power asymmetry reinforced or mitigated the interdependent relationship between Cameroon and France within the realm of economic and security cooperation? Based on the hypothesis that increased interdependence between these two states during this period has strengthened existing power disparity. The paper examines how such dynamics have restrained Cameroon’s autonomy and its capacity to pursue policy goals.

The theoretical framework combines dependency theory, postcolonial …

Claustrum Volume Is Reduced In Multiple Sclerosis And Predicts Disability, Nicole Shelley, Bradley Judge, Dmitriy A Yablonskiy, Robert T Naismith, Matthew R Brier, Anne H Cross

2020-Current year OA Pubs

OBJECTIVE: The claustrum is a small, thin structure of predominantly gray matter with broad connectivity and enigmatic function. Little is known regarding the impact of claustrum pathology in multiple sclerosis (MS).

METHODS: This study assessed whether claustrum volume was reduced in MS and whether reductions were associated with specific disability domains. We compared the impact of claustrum volume reductions on neurological disability versus the well-studied thalamus. Data from the 15,793 participants in the MS PATHS study were used for primary analyses. A second cohort of 71 people with MS and healthy controls from our center was used for validation.

RESULTS: …

Spatiotemporal Association Of Coronavirus Disease 2019 Cases And Deaths With Exposure To Wildfire Particulate Matter In 2020, Thomas C Mchale, David R Boulware, Kelly Searle, Leda Kobziar, Phinehas Lampman, Julio C Zuniga-Moya, Ben Papadopoulos, Andrej Spec, Naomi E Hauser, George R Thompson

2020-Current year OA Pubs

BACKGROUND: Climate change is anticipated to have profound effects on human health, including in infectious diseases. Wildfires have been increasing in frequency and intensity due to climate change and have been linked to worsening respiratory disease outcomes. We aimed to demonstrate whether there was an association between wildfire smoke and coronavirus disease 2019 (COVID-19) in California during 2020.

METHODS: We used an ecologic cohort study with a spatial autoregressive model to test for associations between wildfire smoke, measured as particulate matter < 2.5 µg/m

RESULTS: In an adjusted analysis, we found a 1-month lag increase of 203 COVID-19 cases per 10 000 persons …

Large-Scale Network Analysis Of The Cerebrospinal Fluid Proteome Identifies Molecular Signatures Of Frontotemporal Lobar Degeneration, Rowan Saloner, Nupur Ghoshal, Et Al.

2020-Current year OA Pubs

The pathophysiological mechanisms driving disease progression of frontotemporal lobar degeneration (FTLD) and corresponding biomarkers are not fully understood. Here we leveraged aptamer-based proteomics (>4,000 proteins) to identify dysregulated communities of co-expressed cerebrospinal fluid proteins in 116 adults carrying autosomal dominant FTLD mutations (C9orf72, GRN and MAPT) compared with 39 non-carrier controls. Network analysis identified 31 protein co-expression modules. Proteomic signatures of genetic FTLD clinical severity included increased abundance of RNA splicing (particularly in C9orf72 and GRN) and extracellular matrix (particularly in MAPT) modules, as well as decreased abundance of synaptic/neuronal and autophagy modules. The generalizability of genetic FTLD proteomic …

Cysteine Depletion Triggers Adipose Tissue Thermogenesis And Weight Loss, Aileen H Lee, Irina Shchukina, Prabhakar Sairam Andhey, Maxim N Artyomov, Et Al.

2020-Current year OA Pubs

Caloric restriction and methionine restriction-driven enhanced lifespan and healthspan induces 'browning' of white adipose tissue, a metabolic response that increases heat production to defend core body temperature. However, how specific dietary amino acids control adipose thermogenesis is unknown. Here, we identified that weight loss induced by caloric restriction in humans reduces thiol-containing sulfur amino acid cysteine in white adipose tissue. Systemic cysteine depletion in mice causes lethal weight loss with increased fat utilization and browning of adipocytes that is rescued upon restoration of cysteine in diet. Mechanistically, cysteine-restriction-induced adipose browning and weight loss requires sympathetic nervous system-derived noradrenaline signalling via …

Telemedicine In Nerve Surgery: An Effective Method To Determine Indications For Surgery, Noah S. Llaneras, Ruby L. Taylor, Jonah P. M. Orr, Rachel Alessio, Carolyn Carper, Brendan M. Patterson, Susan E. Mackinnon

2020-Current year OA Pubs

BACKGROUND: The COVID-19 pandemic accelerated the adoption of telemedicine for surgical consultations. Although patient satisfaction has been well documented, limited research exists regarding telemedicine's effectiveness in determining the ability to indicate for surgical care compared with in-office visits. We conducted a retrospective review comparing surgical decision-making via telemedicine versus in-person consultations, hypothesizing that in-office visits would be more effective in establishing a surgical plan than telemedicine.

METHODS: A retrospective review of the medical records of all new patients presenting to the senior author's nerve surgery clinic at a high-volume quaternary referral center between June 2020 and January 2023 was performed. …

Genetically Encoded Biosensors Of Metabolic Function For The Study Of Neurodegeneration, A Review And Perspective, Minglei Zhao, Saman Behboudi Tanourlouee, Sean Mccracken, Philip R Williams

2020-Current year OA Pubs

Nervous system tissue is the most metabolically active in the body and neurons are the primary consumers of oxygen and metabolites in nervous tissue. Many processes support neuronal metabolism, and dysregulation of these processes or intrinsic neuronal metabolism is often tied to neurodegenerative diseases. While many techniques are available to query metabolic function and disease (e.g. Seahorse XF, histology, immunostaining), almost all of these approaches are destructive and few offer cellular resolution. However, genetically encoded biosensors can optically measure metabolic features in any tissue with optical access. Biosensors represent an approach to non-destructively monitor metabolic components and regulatory signaling repeatedly …

Nf2 Loss-Of-Function And Hypoxia Drive Radiation Resistance In Grade 2 Meningiomas, Bhuvic Patel, Sangami Pugazenthi, Shree S Pari, Tatenda Mahlokozera, William A Leidig, Hsiang-Chih Lu, Alicia Yang, Kaleigh Roberts, Patrick Desouza, Kyle P Mcgeehan, Diane D Mao, Namita Sinha, Joseph E Ippolito, Sonika Dahiya, Hiroko Yano, Albert H Kim, Et Al.

2020-Current year OA Pubs

BACKGROUND: World Health Organization Grade 2 meningiomas (G2Ms) often recur and resist therapies. Grade 2 meningiomas with histopathological necrosis have been associated with worse local control (LC) after radiation therapy, but the drivers and biomarkers of radiation resistance in G2Ms remain unknown.

METHODS: We performed genetic sequencing and histopathological analysis of 113 G2Ms and investigated the role of genetic and microenvironmental factors on clonogenic survival after ionizing radiation. We performed transcriptional profiling of our in vitro model and 18 human G2M tumors by bulk RNA sequencing as well as 8 G2Ms by single nuclei RNA sequencing.

RESULTS: NF2 loss-of-function (LOF) …

Beyond Country: Southern Language And Identity In North Mississippi, Meredith Hilliard

Dissertations, Theses, and Capstone Projects

This dissertation is about the language of the US South and the identities of the people who inhabit it. Its purpose is twofold: (1) to explain, on micro- and macro-levels, the processes of enregisterment (Agha 2003) of Southern US English, drawing conclusions about the phenomenon of enregisterment more generally; and (2) to articulate the relationship of Southern redneck identity to this process of enregisterment. It uses a mixed-methods approach that relies primarily on a Critical Discourse Analysis (CDA) methodology, adopting a stancetaking approach (Du Bois 2007) and an enregisterment approach to language and identity, with some quantitative elements, to analyze …

Bimodal Hearing Vs. Bilateral Hearing: Presenting A Review Of Existing Literature To Assist Audiologists With Determining The Optimal Hearing Modality, Eliana Dachman

Dissertations, Theses, and Capstone Projects

While guidelines exist for cochlear implant candidates, there are no specific established guidelines for bimodal users who are considering a 2nd cochlear implant. The objective of this paper is to critically review the literature addressing the question of comparative performance outcomes for bimodal hearing (one hearing aid in combination with a cochlear implant) and bilateral cochlear implants (two cochlear implants). The inclusion criteria were publications comparing bimodal and bilateral cochlear implant performance on speech perception, localization, and subjective quality. Fifteen qualifying papers were identified and analyzed. The results indicate that there are possible advantages to bilateral cochlear implants when assessing …

Biophysical Analysis Of S100a12 And The Nucleosome Core Particle, Christopher Diforte Jr.

Dissertations, Theses, and Capstone Projects

Calcium signaling and chromatin remodeling are fundamental regulatory processes that control protein activity and gene expression, respectively. This thesis investigates the molecular mechanisms by which local ligand binding and structural perturbations propagate allosteric effects across larger protein systems, using two distinct yet mechanistically analogous models: the calcium binding protein S100A12 and the nucleosome core particle. These studies are unified by a shared emphasis on how physical forces govern biological function.

In the first part, we explore calcium mediated allostery in S100A12, focusing on the distinct roles of its two EF-hand calcium binding loops (EF-I and EF-II). Through a combination of …

Excitons And Polaritons In Two-Dimensional Materials Heterostructures - Applications As Qubits, Time Crystals, And Superfluids, Gabriel Pimenta Martins

Dissertations, Theses, and Capstone Projects

This dissertation is concerned with exploring the properties and applications of excitons and polaritons in two-dimensional (2D) materials and heterostructures. It focuses on their potential to form qubits, time crystals, and superfluids. The work is motivated by the unique electronic and optical properties of 2D materials—specifically, their ability to host strongly bound excitons and hybrid light-matter quasiparticles known as polaritons. By exploiting a combination of theoretical modeling and numerical simulations, this work examines the behavior of these quasiparticles under various physical conditions, including strain-induced pseudomagnetic fields, optical microcavities, and periodic external potentials.

The first part of this dissertation is devoted …

Energy Conversion Materials: Computational Design Of Electrocatalysts Toward Sustainable Energy Applications, Courtney M. Brea

Dissertations, Theses, and Capstone Projects

As the global-scale need for sustainable energy technologies emerges due to anthropogenic climate change, electrocatalysis plays a crucial role in facilitating many sustainable processes. Several heterogenous cathode materials can perform different electrochemical activities using water, oxygen, hydrogen, carbon dioxide to deliver renewable electricity and value-added chemicals. By using the density functional theory method, it is possible to explore the structural and electronic properties that govern a catalysts’ activity and selectivity. In this thesis, we start by exploring 48 reconstructed transition metal dichalcogenides edges (MX₂, M = Mo, W; X = S, Se, Te) for carbon dioxide reduction reaction …

Fast Transients From Magnetic Disks Around Non-Spinning Collapsar Black Holes, Justin A. Bopp

Dissertations, Theses, and Capstone Projects

Most black holes (BHs) formed in collapsing stars have low spin, though some are expected to acquire a magnetic accretion disk during the collapse. While such BH disks can launch magnetically driven winds, their physics and observational signatures have remained unexplored. We present global 3D general relativistic magnetohydrodynamic simulations of collapsing stars that form slowly spinning BHs with accretion disks. As the disk transitions to a magnetically arrested state, it drives mildly relativistic, wobbling, collimated magnetic outflows through two mechanisms: steady outflows along vertical magnetic field lines (“Blandford-Payne jets”) and magnetic flux eruptions. With isotropic-equivalent energy of E_iso ≈10 …

Structural Studies Towards The Mechanism Of Scanning And Initiator Trna Recruitment During Eukaryotic Translation Initiation, Da Cui

Dissertations, Theses, and Capstone Projects

The central dogma, proposed by Francis Crick in 1958, marks the direction of the flow of genetic information: from DNA to DNA (DNA replication), DNA to RNA (transcription), and RNA to protein (translation). Each of these is tightly regulated and important for cells and organisms to function correctly, grow, and reproduce.

In the eukaryotic system, the initiation stage of translation is the first, the rate-limiting, and the most regulated stage. It involves direct regulation of multiple eukaryotic initiation factors (eIFs), scanning factors such as DHX29, and other factors such as Poly-A binding protein (PABP). It starts with the small subunit …

The Sub-Syllabic Symphonies Of Self-Learning: How Do Zebra Finches Sing Them?, Abiesha Abiola Budiman

Dissertations, Theses, and Capstone Projects

Learning is a lifelong journey, where the mind and muscle dance to a tune of memory and motion. It begins at infancy and continues throughout life, encompassing everything from singing to achieving peak performance in sports. Complex motor skills involve multiple components and require coordination of several muscles. Humans and animals are extremely adept at learning complex motor skills on their own. However, we do not completely understand how self-directed learning works. One group of animals used to observe self-directed learning are songbirds. Zebra finches, Taeniopygia guttata, are one of the most studied songbird species due to their well-defined …

Alle Or Elle: Automatic Speech Recognition On Louisiana French, Emily Chiu

Dissertations, Theses, and Capstone Projects

Applications of automatic speech recognition largely serve the most commonly spoken languages, but can cause harm through bias when used for speakers of underrepresented language varieties who are not adequately supported. This experiment’s goal is to reveal how state-of-the-art end-to-end ASR systems perform with Louisiana French, a nonstandard variety of French that has suffered a history of state-sanctioned language oppression in Louisiana.