Digital Commons Network^™

Artificial Intelligence Algorithm Predicts Response To Immune Checkpoint Inhibitors, Faisal Fa'ak, Nicolas Coudray, George Jour, Milad Ibrahim, Irineu Illa-Bochaca, Shi Qiu, Adalberto Claudio Quiros, Ke Yuan, Douglas B Johnson, David L Rimm, Jeffrey S Weber, Aristotelis Tsirigos, Iman Osman

2020-Current year OA Pubs

PURPOSE: Cancer treatment has been revolutionized by immune checkpoint inhibitors (ICI). However, a subset of patients do not respond and/or they experience significant adverse events. Attempts to integrate reliable biomarkers of ICI response as part of standard care have been hampered by limited generalizability. We previously reported our supervised machine learning (ML) model in a retrospective cohort of metastatic melanoma.

EXPERIMENTAL DESIGN: In this study, we expanded our testing to include larger cohorts of patients with melanoma accrued at several sites, including patients enrolled in clinical trials in both adjuvant and metastatic settings. We examined pretreatment hematoxylin and eosin slides …

Alekna V. 207-217 W. 110 Portfolio Owner Llc

All Decisions

The Appellate Division, First Department, remanded this class action for trial to determine if the landlord engaged in a fraudulent scheme to deregulate apartments while receiving J-51 tax credits. The court applied the "totality of the circumstances" standard, which superseded the stricter common-law fraud standard, and held that tenants must prove the landlord "knowingly engaged" in the fraudulent scheme. The decision found no impermissible retroactive effect in applying the new standard and affirmed that managing agents can be held liable for their participation in a fraudulent scheme. The court denied the tenant's summary judgment motion and modified the lower court's …

Rna Gene Expression-Based Liquid Biopsies For Diagnosing Hepatocellular Carcinoma, Balvinder Bobbie Saarsal, Ila Chauhan, Jeevan Divakaran, Shizue Mito

School of Medicine Publications

The incidence of non-alcoholic steatohepatitis, a significant risk factor for hepatocellular carcinoma (HCC), is on the rise, highlighting the urgent need for improved diagnostic biomarkers. To date, no systematic analysis has evaluated international studies using liquid samples to assess the utilization of RNA species as biomarkers for HCC. Liquid biopsies based on RNA expression offer more specific and sensitive diagnostic biomarkers for HCC than alpha-fetoprotein (AFP). The inclusion criteria mandated English-language articles, freely available full texts, and primary research published between January 1, 2019, and May 15, 2024. Quantitative analysis was performed using the area under the receiver operating characteristic …

Transcriptional Remodeling Shapes Therapeutic Vulnerability To Necroptosis In Acute Lymphoblastic Leukemia, Anna Saorin, Anna Dehler, Bartimée Galvan, Fabio Steffen, Marine Ray, Dong Lu, Xin Yu, James Kim, Aneta Drakul, Samanta Kisele, Jin Wang, Jean-Pierre Bourquin, Beat C Bornhauser

Faculty, Staff and Students Publications

Insufficient eradication of cancer cells and survival of drug tolerant clones are major relapse driving forces. Underlying molecular mechanisms comprise activated prosurvival and antiapoptotic signaling, leading to insufficient apoptosis and drug resistance. The identification of programmed cell death pathways alternative to apoptosis opens up possibilities to antagonize apoptosis escape routes. We have earlier shown that acute lymphoblastic leukemia (ALL) harbors a distinct propensity to undergo cell death by receptor-interacting protein kinase 1 (RIPK1)-dependent necroptosis, activated by small-molecule second mitochondria-derived activators of caspase (SMAC) mimetics. Despite demonstrated safety and tolerability of SMAC mimetics in clinical trials, their efficacy as single agent …

Improving Particle-Phase Nitrate Measurement In Pm2.5 Filter Sampling: Evaluation Of A Denuder–Nylon Filter Modification In The Spartan Network, Wenyu Liu

McKelvey School of Engineering Graduate Student Theses & Dissertations

Accurate measurement of PM_2.5 composition is of global importance. Evaporation-induced mass loss introduces potential bias in filter-based PM_2.5 measurements, with ammonium nitrate volatilization from Teflon filters being a major contributor to negative mass artifacts. Previous studies have demonstrated that using an acid gas denuder in combination with nylon filters can help recover the nitrate mass. This study evaluates design modifications to the AirPhoton sampling station setup within the globally distributed Surface Particulate Matter Network (SPARTAN) incorporating an additional acid gas denuder upstream and a nylon filter downstream of the existing Teflon filter.

Two co-located AirPhoton Sampling stations were …

Safe Real-Time Obstacle Detection And Navigation Using Cbf–Clf And Cbf–Pid Control, Nicolas M. Hernandez

McKelvey School of Engineering Graduate Student Theses & Dissertations

Traditional robotic navigation pipelines typically follow a three stage architecture: obstacle detection, path planning, and low-level control for trajectory tracking. While effective in static environments, these methods often introduce latency and lack formal guarantees of safety in dynamic or unplanned for scenarios. Our work addresses these limitations by developing a real-time controller grounded in Control Barrier Functions (CBFs) and Control Lyapunov Functions (CLFs), unified through a Quadratic Program (QP). We first investigate a hybrid CBF-PID-QP controller on a 1/10 scale car, where the CBF serves as a real-time safety filter, modifying the PID output to prevent constraint violations. While this …

Re: Butte Priority Soils Operable Unit (Bpsou) Draft Final Bres No. 35 Del Monte Reclamation Improvement Field Sampling Plan (Fsp), Mike Mcanulty

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Re: Butte Priority Soils Operable Unit Revised Draft Final Reclamation Improvement Sites Field Sampling And Investigation Plan (Fsp): Bres No. 45 – Garfield Response To Agency Comments Received June 28, 2024, Mike Mcanulty

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Using The Epic (Exposure, Persuasion, Identification, And Commitment) To Develop A Measure Of Student Buy-In To Laboratory Learning Goals, Elizabeth Blanche Vaughan, A. Montoya-Cowan, Jack Barbera

Chemistry Faculty Publications and Presentations

Buy-in has been described as the series of judgements students make when deciding to engage with a pedagogical practice. Buy-in to pedagogical practices is known to have a meaningful impact on students’ engagement in learning environments, making it a construct of interest for researchers and practitioners. This study develops a measure of student buy-in to faculty defined laboratory learning goals by adapting an existing measure which operationalizes the construct in terms of Exposure, Persuasion, Identification, and Commitment (EPIC). The adapted measure presented in this study, deemed the EPIC-LaG (Laboratory Goals), was developed using learning goals for general and organic chemistry …

A Ka Band High Data Rate Transmitter For Leo Satellites Design And System Simulation, Jean-Hervé Corre, Ronan Foubert, Thomas Dehaene, Hugo Hartmann, Yann Prigent, Bertrand Lechevalier

Small Satellite Conference

This paper addresses the design of a high-throughput Ka-band transmitter for LEO satellites. This article particularly focuses on RF and microwave subsystems and system simulation.

The purpose of this transmitter (named KaLLISTO) is to operate the downlink from a LEO satellite to a ground station. High data rates are required to meet the expressed demand from satellite operators to enable much more data volume downlink. The equipment is the latest state-of-the-art qualified COTS based design. This design is perfectly adapted to New-Space programs, where cost effectiveness, performance and reliability are key factors. The allocated band goes from 25.5 to 27GHz …

Stari: Starlight Acquisition And Reflection Toward Interferometry, John D. Monnier, James Cutler, Michael Meyer, Caden Burkhardt, Akshat Dubey, Jacob Klingler, Raven St. Clair, Shivani Sunil, Daniil Voloshin, Leonid Pogorelyuk, Melissa Flores, Albert Ostoja-Starzewski, Simone D'Amico, Ethan Foss, Prachet Jain, Antonio Rizza, E. Glenn Lightsey, Althea Noonan, Kerri Cahoy, Gautam Vasisht

Small Satellite Conference

We introduce the NASA-funded mission STARI (STarlight Acquisition and Reflection toward Interferometry). We plan to demonstrate the first transfer of starlight between two separate spacecraft, a key technology step towards long-baseline interferometry. Consisting of two propulsive 6U CubeSats flying in Low Earth Orbit separated by ∼100 meters, STARI will reflect a small beam of starlight from the Chief spacecraft toward the Deputy spacecraft, where the light will be collected by an off-axis parabola and focused into a single-mode fiber. With the use of differential Global Positioning System (GPS), visual LED beacons and fast-steering-mirrors (FSMs), we aim for continuous high-throughput fiber …

Spacecraft-Initiated Scheduling Of Ground Stations: On-Orbit Results From Techedsat-11, Adam Gannon, Timothy Recker, Lucas Shalkhauser, Rachel Dudukovich, Janette Briones, Alejandro Salas, Malachi Mooney-Rivkin, Marcus Murbach

Small Satellite Conference

The commonplace practice of manually scheduling communications is challenged by complex and often unpredictable data needs of modern spacecraft. Automation has clear benefits to improve timeliness and efficiency of space communications. In this work we describe and experimentally demonstrate a suite of software which automates the process of scheduling contacts for satellite communications. Service is scheduled based on a spacecraft’s needs and contacts execute automatically without a human in the loop. Requests for service originate onboard the spacecraft, traverse a low-rate control channel to reach a terrestrial server, and are fulfilled by ground station assets. This work describes an experiment …

Augmenting Attitude Knowledge For Optical Communication Terminals On Cubesats By Kalman Filter Based Estimation, Elisa Garbagnati, René Rüddenklau, Chrisopher Schmidt

Small Satellite Conference

Given the growing demand for high data rate transmission on small satellites like CubeSats, free-space optical communication terminals have recently attracted an increasing interest thanks to their capability of ensuring high data rates, compact designs and low power requirements. Yet, the performances of the acquisition and pointing processes crucially depend on their attitude knowledge information. This information is currently available only if an optical link has already been established. Nevertheless, it is likewise important to accurately know the attitude during the link acquisition phase to shorten the search time until the opposing target is found. This aspect is equally relevant …

Tes-11 Goes Dcs Demonstration: A Novel Leo-To-Geo Communication System For Nanosatellites, Marcus S. Murbach, Beau Backus, Brett H. Bestill, David B. Kunkee, Thom Stone, Alejandro Salas, Malachi Mooney-Rivkin, Vasant Chalemcherla

Small Satellite Conference

A satellite in any low Earth orbit (LEO), with access to various geostationary Earth orbit (GEO) satellites, could have a near constant, low bandwidth, real-time link back to Earth during most of an orbit. These GEO satellites could include the two GOES, steadily refreshed since 1974, the European Space Agency (ESA) Meteosat, and the Japanese Space agencies (JAXA) Himawari satellite. These satellites implement the GOES Data Collection System (DCS), or analog, with applications which include meteorology, oceanography, hydrology, ecology, and remote sensing of Earth resources. The relatively compact DCS ground stations used by thousands of researchers transmit data at 100, …

Flight Demonstration Of A Next-Generation Uhf Telecommand Card With Cognitive Clear Channel Assessment For Cubesat Missions, Dhruva Anantha Datta, Pratik Aher, Srinidhi Gonahal, Immanuel Raja, Priyadarshan Hari

Small Satellite Conference

We present a developmental in-orbit demonstration of a TRL-9 UHF telecommand card, flown as a technology demonstrator payload on the fourth and final stage of the PSLV-C60/SPADEX Mission by ISRO. The card is an in-house developed RF PCB utilizing the ADF7030-1 transceiver from Analog Devices, marking the first flight of a new generation of sub-GHz modules with on-chip GFSK modulation and AX.25 packetization, widely used in CubeSat communications. Design and Implementation discussion of the UHF card is discussed, the design philosophy and various debugging techniques employed in the RF PCB development are discussed. The card integrates a digital SPI interface, …

A Torrent-Inspired Large File Transfer System For Small Satellite Swarms, Caleb Adams, Michael Iatauro, Brian Kempa, Sergei Gridnev, Pavlo Vlastos, Caroline Lassiter

Small Satellite Conference

The increasing complexity and coordination requirements of multi-spacecraft missions, distributed space systems, and small satellite swarms necessitate efficient and scalable data transfer mechanisms. Inspired by peer-to-peer file sharing protocols, we present a novel large file transfer (LFT) system designed for NASA’s Core Flight Software (cFS) framework. The LFT system was tested on NASA’s Starling mission, a multi-cubesat swarm with S-Band cross-link capabilities and a mesh network topology. Our system leverages the Better Approach to Mobile Ad-hoc Networking (BATMAN) routing protocol and the Data Distribution Service (DDS) standard to enable seamless communication among swarm members. The LFT system features two primary …

Angel: An Architecture For Simplified Ai/Ml Implementation On Low-Power Fpgas For Small Satellites, Shawn Jones, Benjamin Lewis, Jonathan Phillips, Charles Swenson, Kade Howes, Justin Hulme

Small Satellite Conference

Utah State University has been developing a complier to ease burden of implementing artificial intelligence (AI) and machine learning (ML) algorithms to FPGAs for both low-power and accelerated computation purposes. This system called “Architecture and Network Generalization for Edge computing and Low-power applications” (ANGEL) is aimed at the problem of the growing volume of data collected by small satellites, combined with the increasing interest in AI/ML algorithms to process this data onboard. Executing modern AI/ML algorithms onboard small satellites in GPUs or CPUs demands significant power—often stretching the capabilities of small satellite platforms. FPGAs, particularly the MicroSemi Polar Fire series, …

Optical Inter-Satellite Link Demonstration On Cubesats - Update On The Cubeisl-Iod Mission, Benjamin Rödiger, Jorge Rosano Nonay, Arvind Kumar Balan, Alberto Rodríguez Pérez-Silva, José Franciso Briz Valero, Cristóbal Nieto Peroy

Small Satellite Conference

Free-space optical communication has become a mature technology to extend and replace classical radio channels for data transmission from satellites to the Earth. The advantages of high data throughputs, resilience against electromagnetic disturbances and its robustness against jamming spoofing and eavesdropping makes laser communication attractive for governmental, defense authorities and commercial users. To enable global connectivity and interoperability beyond the line of sight, inter-satellite links are required and therefore terminals with high data rates are necessary to avoid communication bottlenecks. Size weight and power limitations on spacecraft demand highly efficient and miniaturized payloads, especially for use cases on smallest satellites. …

Deployable Diffractive Optical Elements For Small Satellite Lidar Missions, Adam Bahlous-Boldi, Leila Freitag, Amber Cooper, Mary Dahl, Afreen Siddiqi, John Leckey, Kerri Cahoy

Small Satellite Conference

SPECIES (Smart Polyimide Expandable Collector to enable Investigations for Earth Science) is a NASA Earth Science Technology Office (ESTO) project that explores the use of a deployable diffractive optical element (DOE) in a space-based lidar instrument for a 12–24U CubeSat operating in low Earth orbit (LEO). The DOE, a 0.6-meter hybrid multi-level Fresnel zone plate, is made using a tessellation of hexagonal molds, each with a unique number of diffractive levels. It is stowed for launch and deployed on orbit using a 3 meter long extendible boom, which positions the optic at the correct distance from the spacecraft, while guy …

Paradise Lost In The Patent Law? Changing Visions Of Technology In The Subject Matter Inquiry, Dana Remus Irwin

Florida Law Review

In recent decades, the Patent and Trademark Office and the federal courts have dramatically expanded the scope of patentable subject matter—the set of inventions eligible for patent protection. Existing scholarship has taken a narrow view of this expansion. Scholars argue on efficiency grounds that without more meaningful limits on the scope of patentable subject matter, future invention will be impeded rather than encouraged. This Article takes a broader view of the subject matter inquiry, tracing its historical development and its changing theories of technology, from the patent system’s inception to the present. This Article demonstrates that through these theories of …

Dream Big: A Novel, Flexible And Robust ½U Thinsat Constellation Solution, Dillon Embry, Alex Reno, Thomas Foltz, Jasmin Consales, Matt Orvis, John Pugsley, Matthew C. Voss, Jeff Dailey, Hank Voss

Small Satellite Conference

The Dream Big project is a joint initiative between NearSpace Launch (NSL) and NearSpace Education (NSE), combining commercial satellite development with hands-on educational outreach. Focused on advanced manufacturing and space entrepreneurship, the program engages university teams in designing, building, and integrating custom payloads into a novel ½U ThinSat bus. Over the past year, six Midwestern universities completed Phase 1, culminating in the development of six student-built payloads integrated into the NSL bus scheduled for launch in late 2025 or early 2026.

In addition to satellite development, teams conducted high-altitude balloon flights to validate hardware and promote STEM engagement in their …

Dream Big: A Novel, Flexible And Robust ½U Thinsat Constellation Solution, Dillon Embry, Alex Reno, Thomas Foltz, Jasmin Consales, Matt Orvis, John Pugsley, Matthew C. Voss, Jeff Dailey, Hank Voss

Small Satellite Conference

The Dream Big project is a joint initiative between NearSpace Launch (NSL) and NearSpace Education (NSE), combining commercial satellite development with hands-on educational outreach. Focused on advanced manufacturing and space entrepreneurship, the program engages university teams in designing, building, and integrating custom payloads into a novel ½U ThinSat bus. Over the past year, six Midwestern universities completed Phase 1, culminating in the development of six student-built payloads integrated into the NSL bus scheduled for launch in late 2025 or early 2026.

In addition to satellite development, teams conducted high-altitude balloon flights to validate hardware and promote STEM engagement in their …

Pulse-A Mission Overview: Optical Communications For Undergraduate Students, Logan Hanssler, Seth Knights, Graydon Schulze-Kalt, Juan Ignacio Prieto Asbun, Robert Pitu, Lauren Ayala, Rohan Gupta, Vincent Redwine, Spencer Shelton, Catherine Todd, Maya Mcdaniel, Sofia Mansilla, John Baird, Mason Mccormack, Leah Vashevko, Tian Zhong, Michael Lembeck

Small Satellite Conference

Recent advances in the size, weight, and power (SWaP) requirements for space-based sensing have dramatically increased the demand for high-bandwidth downlink. However, high data rate RF transceivers still pose significant SWaP and cost restrictions, especially for university-class CubeSat missions. Optical communication may provide a solution to this challenge, enabling data transmission with order-of-magnitude rate increases over RF while being both secure and SWaP-efficient. The Polarization-modUlated Laser Satellite Experiment (PULSE-A) is a University of Chicago mission to demonstrate optical downlink at a data rate of up to 10 Mbps using circular polarization shift keying (CPolSK). PULSE-A comprises a < 1.5U Optical Transmission Terminal, 3U CubeSat Bus, Optical Ground Station (OGS) employing an amateur telescope, and RF Ground Station (RFGS), all of which are being designed and integrated by a team of over 60 undergraduate students. The mission objective is threefold: (1) to provide hands-on educational experiences for undergraduate students, (2) to make hardware for optical communication systems more accessible via open-source design, and (3) to explore the viability and potential advantages of using CPolSK for optical downlink.

PULSE-A serves an …

Pulse-A Mission Overview: Optical Communications For Undergraduate Students, Logan Hanssler, Seth Knights, Graydon Schulze-Kalt, Juan Ignacio Prieto Asbun, Robert Pitu, Lauren Ayala, Rohan Gupta, Vincent Redwine, Spencer Shelton, Catherine Todd, Maya Mcdaniel, Sofia Mansilla, John Baird, Mason Mccormack, Leah Vashevko, Tian Zhong, Michael Lembeck

Small Satellite Conference

Recent advances in the size, weight, and power (SWaP) requirements for space-based sensing have dramatically increased the demand for high-bandwidth downlink. However, high data rate RF transceivers still pose significant SWaP and cost restrictions, especially for university-class CubeSat missions. Optical communication may provide a solution to this challenge, enabling data transmission with order-of-magnitude rate increases over RF while being both secure and SWaP-efficient. The Polarization-modUlated Laser Satellite Experiment (PULSE-A) is a University of Chicago mission to demonstrate optical downlink at a data rate of up to 10 Mbps using circular polarization shift keying (CPolSK). PULSE-A comprises a <1.5U Optical Transmission Terminal, 3U CubeSat Bus, Optical Ground Station (OGS) employing an amateur telescope, and RF Ground Station (RFGS), all of which are being designed and integrated by a team of over 60 undergraduate students. The mission objective is threefold: (1) to provide hands-on educational experiences for undergraduate students, (2) to make hardware for optical communication systems more accessible via open-source design, and (3) to explore the viability and potential advantages of using CPolSK for optical downlink.

PULSE-A serves an …

A Proposed Process To Define And Collect Project Information For Cost Estimation Of Cubesat Platforms, Ana Carolina Di Iorio Jeronymo, Lidia Hissae Shibuya Sato, Renan Guilherme Soares Menezes, Felipe Oliveira Tavares, Maria Eduarda Mora Camino-Priante, Luís Eduardo Vergueiro Loures Da Costa

Small Satellite Conference

Cost estimation is a key element in the planning and execution of CubeSat mission, as it helps ensure that resources are used efficiently and that mission objectives remain aligned with technical and operational constraints. A solid technical baseline - one that clearly describes the system’s characteristics - is essential for developing reliable cost estimates and for establishing a shared understanding of the project among stakeholders. This paper presents the cost estimation process used at the ITA Space Center for CubeSat platforms. The method follows a structured, eight-step approach adapted from NASA and ESA standards. The steps begin with receiving the …

A Proposed Process To Define And Collect Project Information For Cost Estimation Of Cubesat Platforms, Ana Carolina Di Iorio Jeronymo, Lidia Hissae Shibuya Sato, Renan Guilherme Soares Menezes, Felipe Oliveira Tavares, Maria Eduarda Mora Camino-Priante, Luís Eduardo Vergueiro Loures Da Costa

Small Satellite Conference

Cost estimation is a key element in the planning and execution of CubeSat mission, as it helps ensure that resources are used efficiently and that mission objectives remain aligned with technical and operational constraints. A solid technical baseline - one that clearly describes the system’s characteristics - is essential for developing reliable cost estimates and for establishing a shared understanding of the project among stakeholders. This paper presents the cost estimation process used at the ITA Space Center for CubeSat platforms. The method follows a structured, eight-step approach adapted from NASA and ESA standards. The steps begin with receiving the …

Novel Solutions For Cubecat Attitude Determination And Control Systems Using Pcb Magnetorquers And Low Power Control Solutions, Weston Willardson, Eero Ward, Harrison Thomas, Michael Evans, Michael Williams, Sarahi Oretga-Duran, W. Seth Nelson, David Long

Small Satellite Conference

Satellite attitude determination and control systems (ADCS) can be large, heavy, and expensive relative to a CubeSat’s size, weight, and cost requirements. We have developed a compact, low-mass, inexpensive ADCS prototype suitable for a student-class 1U CubeSat. We utilize three enabling technologies to reduce size, weight, and power (SWaP): 3-axis low-profile printed circuit board (PCB) magnetorquers, a basic sensor package, and computationally efficient control. The PCB magnetorquers are mounted on the exterior of the CubeSat frame to conserve internal volume for spacecraft electronics and payload. Attitude is determined by infrared horizon sensors and a magnetometer. The control algorithms utilize computer …

Development Of A Tool For Planning Fuel-Optimized Collision Avoidance Maneuvers, Saksham Jain

Small Satellite Conference

The need for collision avoidance maneuvers is expected to rise due to growing congestion in low-Earth orbit. This paper presents the development of a tool to automate the generation of collision avoidance maneuvers in response to conjunction events. The tool presented has allowed the Space Flight Laboratory (SFL) to eliminate concerns associated with human error, while concurrently addressing the expected increase in the need for these maneuvers without needing to impose any additional burden on flight dynamics engineers. The automation of this task has reduced the hands-on time required by over 80% when compared to the pre-existing workflow.

If the …

Ibis Advanced Technology For Smallsats, Johan Leijtens, Frank Stelwagen

Small Satellite Conference

For many years, ESA has been involved in attempts to develop a commercially attractive radiation hardened true digital Sunsensor. Although both Galileo Avionica (IT) (now Leonardo) and TNO (NL) developed a sensor based on standard active pixel sensors (APS) none of these products became commercially successful. Although TNO started the development of a single chip true digital Sunsensor in 2004 and a prototype was successfully tested in 2011,^{[1] [2]} the product was neither radiation hardened nor optimized for volume production. Development of this prototype into a real sensor was however never completed.

Although both a digital output and albedo …

Hardware In The Loop Simulation For Commercial Off The Shelf Sensor Qualification In Small Satellite Rendezvous And Proximity Operations, Esme Kovács, Bartłomiej Koszek

Small Satellite Conference

This paper presents a hardware-in-the-loop (HIL) simulation framework designed for the rapid evaluation and qualification of commercial off-the-shelf (COTS) sensors in small satellite Rendezvous and Proximity Operations (RPO). The proposed system supports 2U to 6U CubeSat platforms and enables subsystem-level testing by integrating a real-time mechanical simulator with a software-defined dynamic environment. The setup replicates target satellite motion using a custom 3-DOF rig driven by stepper motors and supports configurable sensor parameters, motion profiles, and automated parameter sweeps. A Microsoft Kinect v2 sensor captures RGB, IR, and depth data, enabling multi-spectral evaluation under varied illumination and material reflectivity conditions. Preliminary …