Digital Commons Network^™

The Rpm-1/Phr Signaling Hub Modulates Tau-Induced Neurodegeneration Through Regulation Of Microtubule Stability And Mapk Pathways In C. Elegans, Xinxing Ding

Theses and Dissertations

Neurodegenerative diseases, including Alzheimer's disease and frontotemporal dementia, are characterized by the accumulation of pathological tau proteins and progressive neuronal loss. Although research regarding tau-mediated toxicity is extensive, the specific pathology that determine whether neurons maintain homeostasis or succumb to collapse under tau-induced stress remain incompletely elucidated. A central, yet still insufficiently understood, feature of these diseases is the disruption of the microtubule (MT) cytoskeleton . The PHR protein family is evolutionarily highly conserved; within this family, RPM-1 in C. elegans functions as an intracellular signaling hub that regulates axon development, synapse formation, axon termination, and various microtubule-associated processes. This …

The Influence Of Rainfall And Land Cover Change On Streamflow Variability In Eastern Florida Watersheds, Brynn Romberger

Theses and Dissertations

Streamflow in Florida watersheds is influenced by both land cover change and rainfall variability, but separating their contributions is difficult because both have changed over recent decades. This study evaluated rainfall trends and land cover change to determine which better explains flood and drought threshold exceedance across 27 USGS streamflow gauges within the St. Johns River Water Management District (SJRWMD) from 1985 to 2025. Streamflow was characterized using change-point, trend, and variability analyses with a six-threshold exceedance framework. Land cover was quantified using the National Land Cover Database (NLCD), rainfall characteristics were derived from the Analysis of Records for Calibration …

Quantifying Dust Structure In An Elliptical Galaxy Via Optical–Near-Infrared Color Mapping: A Detailed Study Of Ngc 6251, Luke Reed

Theses and Dissertations

The giant elliptical galaxy NGC 6251 is a well-studied active radio galaxy that hosts one of the largest known relativistic jet systems, with a projected size of approximately 3 Mpc. In addition to its large-scale radio structure, the galaxy hosts a prominent circumnuclear dust feature surrounding the active nucleus, previously interpreted as a warped dust disk. This thesis focuses on the inner morphology and dust structure of NGC 6251 using archival Hubble Space Telescope observations obtained with the WFPC2 and NICMOS instruments.

The central structure of the galaxy was investigated across multiple wavelengths through image calibration, PSF modeling and subtraction, …

Use Of Active Learning In The Teaching Of The Veterinary Science Course, Cary Rita

All Dissertations

Agricultural education is rooted in active learning, where students develop skills and learning opportunities through hands-on experiences on classroom farms, greenhouses, and even school-based grooming salons. Recent policy and funding revisions have shifted the measures of success in agricultural education programs towards the number of students earning industry-based certifications. This shift has led to the adoption of a test-focused curriculum, often provided by the company offering the certification exam. While the certification-aligned curriculum provides strong content for veterinary knowledge, the problem is that it is often at the expense of hands-on learning. Balancing active learning while also preparing the students …

Unlocking Potential: How High-Fidelity Plcs Protect First Graders From Over-Identification In Tiered Placement, Tomeka D. Love

All Dissertations

Nationally, the demand for special education services under the Individuals with Disabilities Education Act (IDEA) has reached an unprecedented peak, serving 7.5 million students (representing 15% of all public school students) in the 2022–23 school year. While national academic discussions regarding socioeconomic hurdles and systemic inequities frequently center on urban environments, minoritized students in rural communities face a persistent and disproportionate over-representation in special education. This trend is driven by complex intersections of geographic isolation, systemic resource allocation issues, and cultural misalignments in assessment practices.

At the local level, Love and Logic Elementary School [pseudonym], a rural K-5 institution, faces …

Counting The Days: The Impact Of Career And Advanced Coursework On Academic And Perceptual Outcomes For Eighth Grade Students Who Are At Risk Of Experiencing Adverse Educational Outcomes, Jamie Megna

All Dissertations

This study addressed limited academic achievement and limited access to meaningful learning opportunities among eighth grade students who are at risk of adverse educational outcomes. The purpose of this study was to examine how implementing career-based and advanced coursework opportunities for eighth grade students who are at risk improves student engagement with relevant and meaningful learning while supporting progress in academic achievement. The study achieved this by reducing barriers to career-based and advanced coursework to expand access to these learning environments for students who are at risk.

Using a mixed-methods design, the team collected and analyzed data to monitor the …

Lesson Plans, Teacher Self-Efficacy, And Ml Achievement: A Quantitative Study Of Teachers Incorporating Language Acquisition Within Lesson Plans To Improve Multi-Lingual Learner Achievement, Patrick R. Withers

All Dissertations

South Carolina’s public schools are increasingly facing the challenge of addressing the needs of a growing number of multi-lingual (ML) learners. ML learners are increasingly marginalized in society and schools, and show lower rates of achievement within schools. Schools are faced with providing effective tier 1, universal instruction for all students, including ML learners. This quantitative study seeks to improve ML achievement through incorporation of language acquisition skills within the classroom lesson plans. It is also the goal of this study to measure teacher self-efficacy of the selected study cohort.

This study takes place in a large suburban high school …

Closing The Gap: Addressing College Readiness Inequities Through Dual Enrollment Policy And Practice Reform, Tabytha L. Walls

All Dissertations

This dissertation employed improvement science to increase college readiness at Phosphate Grove High School by expanding the dual-enrollment program. At this research site, a majority-minority, Title I high school in South Carolina, dual enrollment serves as the primary pathway towards college readiness on the state report card. College readiness at this school has been low for many years, and participation in the program has not been representative of the school's size. Many students meet the academic eligibility requirements, but students and families are unaware of the opportunities and have difficulty navigating the sign-up process.

This study aimed to address some …

Making The Case For Historically Minoritized Students At Career Centers With A Focus On Agriculture, Janine Honey Sutter

All Dissertations

Historically minoritized students are still underrepresented in many Career and Technical Education (CTE) programs, such as agricultural education, even though these programs offer valuable academic, workforce, and postsecondary opportunities. This dissertation used Improvement Science to explore whether educator perceptions and communication practices played a role in this underrepresentation at Liberty Career Center. It also examined whether targeted informational interventions could help educators become more aware of and more positive about Career Center opportunities.

Following Improvement Science principles, the study used a continuous improvement approach to find system-level barriers and test new ways to improve communication between the Career Center and …

Growing Our Own Garden: The Implementation Of Cross Curricular And Cross Grade Level Teacher Rounds To Increase Professional Learning Individualization And Feedback, Logan Greene

All Dissertations

Educators are constantly faced with balancing the demands of teaching and professional learning expectations from their districts. Concurrently, administrators are routinely prevented from providing adequate feedback for classroom instructional practices with observations instead focused upon generic and formulaic checks for classroom activities. This results in a gap of intentional professional learning and growth for educators.

The idea of instructional rounds sought to provide teacher-to-teacher feedback for educators to grow their practice together. The original theory focused on groups of teachers operating under a school or district goal of improvement. Instructional rounds have shown positive effects for teacher happiness and student …

Exploring The Effect Of Writing-To-Learn Practices On Critical Thinking In A Graduate Teacher Education Program, Alisa Alybaeva

GHEA21 Publications

This project investigates the impact of writing-to-learn practices on the critical thinking skills of first-year students in a graduate teacher preparation program in the Kyrgyz Republic. For this purpose, multiple writing-to-learn strategies (such as Focused Freewriting, Loop Writing, Private Freewriting, Writing in the Zones, Dialectical Notebooks, and others) were integrated into the academic writing course instruction. The analysis of student responses at the beginning and end of the course demonstrated a movement from general statements towards richer responses with evidence of perspective taking, metacognitive reflection, and synthesis. Additionally, student reflections revealed that writing-to-learn practices provided space to overcome writing anxiety, …

Reading The Western Canon From Elsewhere: Teaching Political Theory Through Writing, Zlata Božac

GHEA21 Publications

No abstract provided.

Confronting Founding Injustices: Reconstructive Constitutional Adjudication And Constitutional Legitimacy In Postcolonial States, Mutasim Abuzeid

International Studies (MA) Theses

Why do some postcolonial constitutions achieve higher constitutional legitimacy than others? Across the Global South, constitutions have proliferated while legitimacy remains uneven and contested. Existing scholarship explains variation in constitutional legitimacy in postcolonial states through three dominant paradigms. Institutionalist theories equate legitimacy with procedural design and endurance, presuming that stable institutions generate compliance and, over time, diffuse support. Transformative constitutionalism locates legitimacy in social justice, emphasizing judicial doctrines such as proportionality and reasonableness to advance equality and material inclusion. Transitional justice approaches, by contrast, locate moral repair largely outside constitutional law—through truth commissions, reparations, and memory projects—often leaving the constitutional …

Aegic Blogposts - Climate Impacts On Grain Production, Ross Kingwell, Nicholas Thorsager, David Stephens, Ian Foster, Imma Farre

Grain and other field crops published reports

The Australian Export Grains Innovation Centre (AEGIC) was an independent, not-for-profit organisation established in 2012 by the Western Australian Government and the Grains Research and Development Corporation (GRDC). Its core mission was to increase the value and international competitiveness of Australia’s multibillion-dollar export grains industry. AEGIC ceased operation at the end of 2025.

Early in its history between 20 to 30 staff from the former Western Australian Department of Agriculture were seconded to AEGIC. Following the formation of DPIRD, AEGIC continued to receive substantial annual funding support from DPIRD.

This publication is a legacy document containing collated AEGIC blog posts …

Investigations Into The Structure-Property Relationships Of Magnetic Fe2mnsn And Gradient Copt Thin Films For Next-Generation Magnetic Technologies, Lance Griswold

Theses

e study of spin-based electronic phenomena, or spintronics, has become increasingly important in materials science and condensed matter physics due to its potentialto enable next-generation magnetic technologies, including advanced memory devices and quantum computing. Central to this field is the relationship between a material’s atomic structure and its physical properties, which requires precise control over synthesis conditions to achieve desired magnetic and electronic behavior. In this work, I investigate the structure–property relationships of several magnetic thin-film systems, each designed to address a specific technological challenge. All films were synthesized using magnetron co-sputtering from elemental magnetic and non-magnetic targets, either at …

Power Signature-Based Hardware Security Techniques For The Internet Of Things, Ashish Mahanta

Dissertations

The rapid proliferation of the Internet of Things (IoT) has introduced significant security challenges, particularly concerning stealthy, instruction-level malicious code injections that evade traditional software defenses. While conventional power analysis techniques are highly effective at detecting such subtle abnormalities, they require capturing high-resolution, voluminous power trace data. This dependency necessitates bulky data acquisition (DAQ) instrumentation, power-hungry analog-to-digital converters (ADCs), and intensive computational resources, making these methods impractical for deployment on resource-constrained IoT devices. To bridge this critical gap, this dissertation presents a novel hardware security paradigm, the Power Rising and Descending Signature (PRIDES) methodology. Instead of quantizing actual power consumption …

Agent-Based Modeling Of Cellular Dynamics In Adoptive Cell Therapies, Yujia Wang

Dissertations and Theses (Open Access)

Adoptive cell therapies (ACT) have shown promising progress in combating cancer, but clinical responses remain heterogeneous. Key determinants, including the functional states of infused cells, tumor–immune interactions, and dosing strategies, are difficult to resolve experimentally in the dynamic and heterogeneous tumor microenvironment, limiting optimization of ACT products and treatment regimens. To address the gap, we developed ABMACT (Agent-Based Model for Adoptive Cell Therapies), a computational framework that reconstruct key cellular functions, interactions, and molecular signatures to recapitulate cell population dynamics associated with differential treatment responses. ABMACT encodes autonomous “virtual cells” using literature-informed rules calibrated with experimental data, enabling simulation of …

Transcriptional Regulation In The Uterine Luminal Epithelium, Evelyn A. Carrion

Dissertations and Theses (Open Access)

Transcriptional Regulation in the Uterine Luminal Epithelium

Evelyn A. Carrion

Advisor: Richard R. Behringer, PhD

Abstract

The uterus is an organ comprised of multiple tissues that are essential for women’s health and reproduction. The uterus is composed of multiple tissue layers, including the perimetrium, myometrium, and the endometrium. The endometrium is the inner lining of the uterus, and contains the luminal epithelium, glandular epithelium, and stroma. The luminal epithelium is a simple columnar layer of cells that is necessary for embryo implantation. The uterus is derived in part from the embryonic precursor tissue called the Müllerian duct. There are no …

Ai-Driven Segmentation And Volumetric Response Modeling Of Liver Regions To Radiotherapy, Aashish Chandra Gupta

Dissertations and Theses (Open Access)

In liver-directed radiotherapy (RT), liver regions receiving higher doses typically undergo atrophy while contralateral/adjacent lower-dose regions may exhibit compensatory hypertrophy through regeneration of healthy tissue. Optimizing the RT plan to promote regional hypertrophy while minimizing the risk of developing atrophy has the potential to enhance post-RT liver function and long-term survivorship. However, current clinical practice largely relies on global liver dose-volume metrics during RT-planning, which may obscure favorable dose-response correlation and limit actionable guidance for clinicians. Therefore, we hypothesized that post-RT regional liver response is governed by a combination of region-specific dose-volume and patient clinical features, and that these responses …

Oxidative Stress Mediated Glutamate Release And Nmda Receptor-Dependent Synaptic Remodeling In Radiation-Induced Cognitive Dysfunction, Thanh Lam

Dissertations and Theses (Open Access)

In children younger than 14 years old, the brain and other parts of the central nervous system are the most common sites for solid tumors. Radiotherapy is an effective treatment for central nervous system (CNS) tumors. However, it often causes a progressive decline in cognitive functions, which is especially devastating for pediatric patients. Although post-mitotic neurons are generally considered resistant to radiation-induced immediate cell death, ionizing radiation causes complex neurochemical and structural changes that damage synaptic integrity. In this study, we examined the molecular cascades following a 10 Gy radiation dose applied to mouse cortical neurons. We found that radiation-induced …

From Geometry To Recognition: A Quantitative Framework For Tcr-Pmhc Structural Analysis In The Age Of Predicted Structures, Kun Hee Kim

Dissertations and Theses (Open Access)

Recognition of antigen by a T cell begins with a single physical event, the engagement of the T cell receptor (TCR) with a peptide-major histocompatibility complex (pMHC), and this interaction is encoded in the geometry with which the receptor docks onto the composite pMHC surface. Whether that docking geometry is biologically organized, and whether the structures now produced at scale by prediction preserve recognition or only reproduce that organization, are the two questions this thesis addresses. Two gaps stand in the way. The first is a gap of measurement, because docking geometry has never been made quantitatively comparable across many …

Developing A Deep-Learning Model To Segment White Matter Lesions In Cerebral Palsy, Varsha Kumar, Hyukjin Yun, Rose N. Gelineau-Morel, Avner Meoded

Posters

No abstract provided.

My God Is My Mercy: A Philological And Exegetical Study Of The Use Of Hesed In The Old Testament And Its Echoes In The New Testament, Sister Mary Agatha Hester, O.P.

Theology Graduate Theses

One little word can have a mighty impact. This is the case with the Hebrew word hesed.  Having encountered hesed in Scripture scholarship, pursuit of its nature and nuance has become a quest that has resulted in this thesis. What follows is a philological and exegetical study of the meaning and use of hesed in the Old Testament, its intertextual echoes in the New Testament, and its implications for right living. First, the use of hesed is analyzed in the context of the Old Testament, focusing on Exodus 34:6-7, which serves as the exemplar text. Using the work of …

Full Issue

Comparative Civilizations Review

No abstract provided.

Effects Of Peer-Mediated Constant Time Delay Instruction On Science Vocabulary Acquisition For Students With Moderate Intellectual Disabilities, Amy S. Roberts

Electronic Theses and Dissertations

This study examined the effectiveness of combining peer-mediated embedded instruction with constant time-delay (CTD) procedures to improve Agriscience vocabulary learning among secondary students with moderate intellectual disability who were educated in an inclusive Agriscience classroom. A multiple-probe across participants design was conducted with three students with moderate intellectual disability. Trained peer tutors provided embedded vocabulary instruction during naturally occurring classroom activities. Results showed an increase in independent correct responding for all participants following the implementation of the intervention. Procedural fidelity, interobserver agreement, Tau-U effect size, and social validity data further demonstrated that the intervention was implemented consistently and was viewed …

Leapp Vowel Spelling Visual Chart, Chenell Loudermill, Tamar Greenwell

Purdue-LEaPP Instructional Toolkit

The LEaPP Vowel Spelling Visual Chart is a spelling aid that can be used to support learners as they acquire knowledge of basic and advanced vowel spellings. This document contains basic and advanced spellings for vowel sounds in the English language. It also contains a key for educators and a template for learners to tailor to their known spelling patterns.

Leapp Sight Word Protocol, Chenell Loudermill, Tamar Greenwell

Purdue-LEaPP Instructional Toolkit

The Sight Word Protocol provides guidance for explicit teaching of a sight word. It includes a script for the educator that provokes multiple modalities supporting errorless learning. The script provides 15+ trials for learners to spell a target word during the learning process and includes a special template to be used with instruction. This document also includes instructions on how to use the special template, helpful instructional hints, list of materials needed, and optional items to support the learner as they work through the sight word protocol. This protocol should be used after the educator has completed the basic or …

Jison Jiei: Offensive Realism And Imperial Japan's Spiral Toward Regional Hegemony, John William Dodd

War, Diplomacy, and Society (MA) Theses

This thesis examines Imperial Japan’s march from the Mukden Incident of 1931 to the attack on Pearl Harbor in 1941 through the lens of offensive realism. It asks to what extent Japan’s prewar grand strategy can be understood as a bid for regional hegemony, and what that interpretation reveals about the relationship between power politics, international law, and future great-power crises. Rather than treating Japanese expansion as irrational madness or reducing it only to ideology or militarism, this thesis argues that Japanese leaders acted according to a recognizable strategic logic.

Proceeding from theory to historical analysis, this project first situates …

Understanding Hypertensive Renal Injury: A Well-Structured Approach, Peter A Doris

The Brown Foundation: Institute of Molecular Medicine

No abstract provided.

Technique-Level Normalization For Cybersecurity Intelligence: An Empirical Evaluation Of Att&Ck Attribution From Hids Alerts Using Fine-Tuned Transformers And Metadata Re-Ranking, Emad Sherif

International Journal of Cybersecurity Intelligence & Cybercrime

Cybercrime investigations increasingly depend on the ability to interpret large volumes of automated security events. For organizations without dedicated security operations centres, a situation common among small and medium enterprises, the manual translation of raw alerts into structured threat intelligence represents a critical bottleneck that slows investigative triage and limits cross-case comparability. This paper evaluates an automated enrichment pipeline designed to address this bottleneck by mapping security events to standardised adversary behaviour labels drawn from the MITRE ATT&CK framework, supporting both operational response and cybercrime investigation workflows. We compare three pipeline configurations, a general-purpose encoder model, a cybersecurity domain-adapted variant, …