Digital Commons Network^™

Knowledge And Awareness Of Thalassemia Carrier Screening Among Thai Medical Students, Pawitchaya Jariyapongpaiboon, Boodchiya Rojsuriyawong, Suwijak Meenapa, Pacharapan Surapolchai, Prapasri Kulalert, Chanapat Chouwalit, Thanpisit Phanawal, Prapasiri Niamkamnoet, Parin Pongrungsee, Kitiwan Rojnueangnit

Asian Medical Journal and Alternative Medicine

Introduction: Thalassemia is the most common hereditary hemolytic anemia in Southeast Asia, including Thailand. Despite thalassemia screening tests being currently performed in all Thai pregnant women, this approach can sometimes be too late. Prevention would be improved if we could perform thalassemia screening tests prior to pregnancy.

Objectives: Assess the knowledge and awareness of thalassemia screening in medical students.

Methods: A descriptive cross-sectional survey among Thai medical students in 16 universities, during April 2022- May 2023, by using a valid set of research questions in the online-based questionnaire to assess their knowledge and awareness of carrier screening tests and intention …

Usa V. Derby Clerfe

2026 Decisions

USDC for the Western District of Pennsylvania

Timothy Mclaughlin V. International Brotherhood Of Teamsters Local 249

2026 Decisions

USDC for the Western District of Pennsylvania

Threads Across The Atlantic: A Dialogue Of Feminist Writings Between Portugal And Cape Verde, Elliana Shillig Venancio

Theses and Dissertations

This thesis examines the feminist literary traditions of Portugal and Cape Verde through a comparative analysis of Ana de Castro Osório’s Infelizes and Dina Salústio’s Mornas eram as noites. Separated by nearly nine decades and an ocean, these two works nonetheless converge in their insistence on women’s autonomy, bodily sovereignty, and resistance to patriarchal structures. Drawing on Hélène Cixous’s theory of écriture féminine and Kimberlé Crenshaw’s framework of intersectionality, this thesis argues that despite the significant differences in time, geography, and socio-political context that separate these authors, powerful threads of feminist consciousness bind their writing together. At the same time, …

“Lost In Transcription?”: A Case Study Of Using Ai And Humans-In The Loop To Create Captions And Transcripts For A Library Symposium, Eva Lu, Sonya Panangaden, Mark Weiler, Michael R. Clark

Library Publications

In many regions, academic libraries are increasingly expected to generate recorded content as part of their services and operations, such as hosting public or academic events. These recordings require quality captions and transcripts to address the needs of users with disabilities as required by human rights legislation. Unfortunately, auto-generated captions cannot be relied upon to provide error-free outputs. This paper presents a case study of how we used AI and involved 35 volunteers from across North America to create captions and transcripts for recordings of a 3-day virtual accessibility symposium. This initiative was put in place to ensure all attendees …

Analyzing The Transition From Writing Center Tutor To Graduate Student Instructor, Luci Mackenzie Sullivan

Theses and Dissertations

Writing center tutoring is almost universally considered to be beneficial preparation for graduate student instructors (GSIs) of writing, so much so that many programs require writing center experience as part of their GSI training. Despite various similarities between the roles of tutor and teacher, the precise ways in which writing center experience influences GSIs as teachers remain unclear. This IRB-approved, mixed-methods study builds on previous empirical scholarship on transfer between tutoring and teaching to determine how new GSIs with previous writing center experience integrate practices, knowledge, and dispositions developed in the writing center. My findings echo those of previous studies …

Malt1 Protease Inhibition Restrains Glioblastoma Progression By Reversing Tumor-Associated Macrophage-Dependent Immunosuppression In Mice, Juliana Hofstätter Azambuja, Saigopalakrishna Yerneni, Lisa Maurer, Hannah Crentsil, Gabriela Debom, Linda Klei, Mei Smyers, Chaim Sneiderman, Kristina Schwab, Rajesh Acharya, Aivi Nguyen, Josie Emery, John Little, Jeffrey Meridew, Yijen Lin Wu, Prasanna Ekambaram, Dong Hu, Pete Gough, John Bertin, Ari Melnick, Gary Kohanbash, Riyue Bao, Peter Lucas, Linda Mcallister-Lucas

College of Life Sciences Faculty Papers

MALT1 protease is an intracellular signaling molecule that promotes tumor progression via cancer cell-intrinsic and cancer cell-extrinsic mechanisms. MALT1 has been mostly studied in lymphocytes, and little is known about its role in tumor-associated macrophages. We show that MALT1 is expressed in glioblastoma (GBM)-associated macrophages. Mechanistically, GBM tumor cells induce a MALT1-NF-κB signaling axis in macrophages, leading to enhanced macrophage migration and polarization toward an immunosuppressive ('M2-like') phenotype. Inactivation of MALT1 protease promotes transcriptional reprogramming that reduces migration and restores a macrophage anti-tumor 'M1-like' phenotype. Preclinical in vivo analysis shows that MALT1 inhibitor treatment results in immuno-reactivity of GBM-associated macrophages …

A Retrospective Study Of The Impact Of Standard Versus Staggered Arc Arrangements In Vmat Planning For Localized Prostate Cancer., Samantha J. Arthur

Masters Projects

Purpose: To evaluate whether implementing a staggered beam arrangement in volumetric modulated arc therapy (VMAT) improves treatment plan quality by enhancing normal tissue and organ-at-risk (OAR) sparing in patients with localized prostate cancer.

Methods: Ten patients meeting the study inclusion criteria were retrospectively replanned using both a standard arc technique and a staggered arc arrangement. Both plans were generated using identical optimization objectives and planning parameters. Dosimetric comparisons were performed after normalizing both plans to equivalent planning target volume (PTV) coverage. Dose-volume metrics were evaluated for the PTV, rectum, bladder, and penile bulb.

Results: The staggered beam arrangement produced statistically …

Teaching Writing With Confidence: A Professional Learning Series To Build Special Education Teachers' Knowledge And Self-Efficacy For Explicit Writing Instruction, Lindsay E. Bowen

Masters Projects

Writing is an essential skill used to communicate ideas effectively, assess understanding, and demonstrate critical thinking across educational and workplace settings. Yet, research demonstrates that a majority of special education teacher preparation programs do not offer standalone courses in writing instruction methods, leaving many special education teachers to enter the profession with limited knowledge of effective writing instruction for students with high-incidence disabilities. This project explores current research on effective sentence-level writing instruction for students with high-incidence disabilities, as well as a research-based approach for applying these practices in a systematic yet adaptable manner to meet the needs of individual …

Garcia V. Miller

All Decisions

In this proceeding that converted from a holdover to a nonpayment proceeding and settled by stipulation requiring Petitioner to offer Respondent a rent-stabilized lease at $2,145/month, Respondent moved to compel compliance with the stipulation. The court granted Respondent's motion, ordering Petitioner to provide the agreed rent-stabilized lease and comply with outstanding repair obligations.

Comparing Boost Ptv/Plans Made On The Initial Prone Whole-Breast Ct Vs A Near-Boost Supine Re-Simulation Ct In Hypo-Fractionated Wbi Using A 3-Field Photon Boost Technique, Daniel Garcia

Masters Projects

Purpose: To evaluate dosimetric differences between breast boost plans generated on an initial prone whole-breast computed tomography (CT) simulation and those generated on a near-boost supine re-simulation CT acquired closer to boost delivery.

Methods: Ten patients receiving hypo-fractionated whole-breast irradiation followed by a sequential boost were retrospectively analyzed. Boost plans were generated using a three-field photon technique on both the initial prone CT and a near-boost supine CT. Target volumes, target coverage metrics, conformity index (CI), and organ-at-risk (OAR) doses were compared using paired statistical analyses.

Results: Mean clinical target volume and planning target volume were significantly smaller on the …

Growing Students' Fluency And Comprehension Skills, Makayla Irwin

Masters Projects

Research emphasizes the importance of building strong foundational skills among early readers. While reading is taught everyday in the classroom, there are not enough strategies and knowledge known by teachers to effectively instruct on fluency and comprehension skills. Fluency and comprehension are known as being crucial aspects of the reading process, but they have been inadequately included in many literacy curriculums. This project, grounded in research and well developed theories, holds fluency and comprehension instruction high in regard to the development of a proficient reader.It has been found that educators lack the training, resources, and confidence necessary to successfully teach …

Automated Classification, Measurement, And Semantic Segmentation Of Open-Web Joists From Point Cloud Data, Justin Raymond Dworacek

Theses and Dissertations

This thesis presents a BIM-oriented methodology for the automated classification, measurement, and segmentation of structural trusses from point cloud data. A real truss point cloud and a complementary synthetic dataset derived from CADBIM Revit families were used to develop and evaluate the workflow. Classification was performed using a rule-based Python algorithm based on principal component analysis, side-view feature extraction, and family-specific geometric decision logic, while a separate family-aware script was used to extract key truss dimensions. Semantic segmentation was evaluated using a PointTransformerV3 model to separate truss and non-truss points in mixed point cloud scenes. The results demonstrated strong performance …

A Distinct Form Of Fat Fibrosis Is Linked To Insulin Resistance In People With Hiv, Diana L Alba, Alaa Abdellatif, Moon Kyung Choi, Stephen M Brown Mayfield, Thuy An T Pham, David I Berrios, Antonio E Rodriguez, Marin Ewing, Tony R Figueroa, Judy Gonzalez-Vargas, Ningyan Zhang, Zhiqiang An, Dawei Bu, Steven G Deeks, Philipp E Scherer, Peter W Hunt, Suneil K Koliwad

The Brown Foundation: Institute of Molecular Medicine

BACKGROUND

Despite antiretroviral therapy (ART), people with HIV (PWH) are at heightened risk for insulin resistance (IR) and type 2 diabetes (T2D). Subcutaneous adipose tissue (SAT) fibrosis contributes to metabolic disease, but its role in IR among PWH is unknown. We investigated the relationship between SAT fibrosis and IR in PWH, along with transcriptional signatures to distinguish it from SAT fibrosis due to obesity.

METHODS

We analyzed body composition and SAT fibrosis (hydroxyproline) in 46 PWH and 74 people without HIV (PWoH), excluding individuals with T2D. We examined fibrosis-related gene transcription in the SAT using a targeted panel and measured …

Treating Intractable Nausea And Vomiting In Cerebellar And Medullary Stroke, Adil Bhatti, Peter Schultz, Shantanu Amin, Taimur Khalid, John Varras

Student Publications

Cerebellar and medullary stroke can cause persistent nausea and vomiting that may be resistant to initial antiemetic monotherapy and interfere with oral intake and recovery. Evidence guiding management remains limited. We report a 48-year-old man with diabetes mellitus and acute-to-subacute infarcts involving the inferomedial right cerebellum and posterior right medulla who presented with 10 days of persistent nausea and vomiting accompanied by focal neurologic symptoms. Diabetic gastroparesis was considered, but abdominal imaging and gastric emptying scintigraphy did not support a contributory gastrointestinal cause. Ondansetron and metoclopramide provided only limited or temporary relief. Symptoms improved after sequential escalation to ondansetron, chlorpromazine, …

Breast Cancer Knowledge, Awareness And Screening Practices Among Female Healthcare Workers In Al-Mukalla, Yemen, Wafa Al Shoaeeb, Ahmed M. Badheeb, Faisal Ahmed, Amen Bawazir, Abdulla Bin Nabhan, Mohammed Badheeb, Abdulkader Bayazid

Sultan Qaboos University Medical Journal

Objectives: Breast cancer (BC) is the most common malignancy among women worldwide and represents a significant burden for Yemeni women. Early detection through breast self-examination (BSE) and knowledge of risk factors and symptoms are crucial. This study aimed to assess awareness, knowledge and practice regarding BC risk factors, symptoms and BSE among female healthcare workers (HCWs) in Al-Mukalla, Yemen. Methods: This cross-sectional study was conducted from September to October 2022 at three public hospitals in Al-Mukalla, Yemen. A census sampling approach was used to recruit HCWs. Data were collected using a validated self-administered questionnaire covering breast awareness practices, risk …

Mystical Revelation And Knowledge Of God: Reclaiming Spirituality In Theology Through The Mystics, Elizabeth A. Merski

Electronic Theses and Dissertations

Since the scholastic era, the pursuit of God has occurred preeminently through reason, leading to an imbalanced theology of God that persists to the present day in the form of intellect-centered theology. As a resolution, this work proposes that the mobilization of private, mystical revelation as a source of legitimized theological knowledge of God has the potential to close the existent epistemological gap between reason/belief and theology/spirituality, demonstrating the integral unity between authentic knowledge of God and the receiver’s personal acceptance of God in faith. After examining the required methodological components for the discipline of theology and identifying criteria for …

Beyond The Pencil: Creating Early Writers, Pamela L. Gernaat

Masters Projects

“Schools in many countries are faced with the challenge of developing student writing proficiency. Identifying and implementing effective writing instruction for young, beginning writers play important roles in improving student writing performance. Providing effective writing instruction to beginning writers can promote writing development and minimize the number of children who encounter challenges in learning to write” (Finlayson & McCrudden, 2022, p. 1). Despite the amount of research that has been done on the importance of early writing instruction, many lower elementary students struggle with the ability to write and cannot keep up with the cognitive demands of written instruction. Many …

Sandbox Fictions, Douglas Sarro

Osgoode Hall Law Journal

Regulatory sandboxes are designed to give firms space to offer novel products and services to consumers on a trial basis, under an interim, tailor-made regulatory regime. Ideally, this leaves regulators better placed to understand how rules ought to be modified to accommodate new, socially beneficial offerings on a more permanent basis. But little is known about sandboxes’ implications for consumers. Will they reduce barriers to entry for innovative offerings that do a better job of serving consumer needs? Or will they lead regulators to compromise on consumer protections, allowing low-quality or even fraudulent offerings to flow into the markets they …

Effective Visibility In The Infrared Bands, Peter L. Dean-Erlander, Steven T. Fiorino, Ronald G. Driggers

Faculty Publications

Visibility is an atmospheric metric for the comparison of terrestrial imaging conditions and locations. A limitation of visibility is that it is defined for the visible spectrum only, and there is no simple infrared equivalent. This study compares three reflective infrared wavebands: near-IR (NIR), shortwave IR (SWIR), and extended shortwave IR (eSWIR), to the visible band across a global set of cities to develop three rule-of-thumb functions for IR effective visibility. To accomplish this, a radiometric sensor model is combined with the Laser Environmental Effects Definition and Reference (LEEDR) software package to calculate the visibility of a black-and-white contrast target …

An Atmospheric Optical Turbulence Structure Parameter Measurements System Based On Direct Ri Sensing Using High-Resolution Fiber-Optic Sensors, Matej Njegovec, Simon Pevec, Vedran Budinski, Boris Macuh, Melissa K. Beason, Denis Onlagic

Faculty Publications

The paper presents a method to characterize the refractive index structure parameter (C_n²) associated with optical turbulence directly. The characterization system is based on miniature, high‑resolution, all‑fiber refractive index (RI) sensors. The refractive index sensors employ open‑path, low‑finesse Fabry–Perot interferometers that are approximately 8 mm long and 200 μm in diameter. The active part of the interferometers is made of ultra‑low‑expansion glass, which eliminates the influence of thermal expansion on the refractive index measurements. The proposed refractive index sensor, operating in a differential configuration, achieved a resolution of 2×10^-9 RIU using a custom‑designed spectral interrogation system …

Tuan Mai V. Sp 1143 Second Llc

All Decisions

Respondent wins summary judgment dismissing nearly all overcharge claims. Reargument denied—Burrows v 75-25 153rd St. did not require a different result since petitioner offered no evidence of fraud whatsoever. The 2012-2013 increase is explained by the Carbone renewal lease; the 2016 IAI is substantiated by contractor affidavits, design drawings, and photographs. One narrow factual dispute survives: whether the $1,032 cabinet-door component of the 2013 IAI was proper where the door count is disputed. Respondent awarded attorneys' fees as prevailing party on the central claims; parties to confer on damages amount.

The Mathematics Of Calendar Patterns: Day-Of-Week Phenomena, Number Patterns, And Recreational Investigations, Vijender Nallapu, Mrinal Kanti Roychowdhury

School of Mathematical & Statistical Sciences Faculty Publications

Calendars are among the most familiar mathematical structures encountered in everyday life. Beyond their practical use in organizing dates and measuring time, calendars contain a rich collection of numerical patterns, symmetries, and arithmetic relationships. Many of these patterns can be explored using only elementary mathematics, making calendars an attractive subject for recreational investigation and mathematical enrichment.

In this article we examine several mathematical properties arising from the structure of monthly calendars. We investigate arithmetic patterns associated with rows, columns, and rectangular blocks of dates, establish properties of calendar squares, and explore connections with modular arithmetic through day-of-week calculations. We also …

Vitamin D As A Candidate Host Susceptibility Factor In Sugar-Driven Oral Dysbiosis, Moldir Turaliyeva, Nuraly S. Akimbekov, Ilya Digel, Adil Y. Yerezhepov, Mohammed Razzaque

School of Medicine Publications

Introduction: Sugar-sweetened beverages (SSBs) represent a modifiable dietary factor that promotes oral dysbiosis by supplying fermentable sugars and generating low-pH conditions that favor acidogenic and acid-tolerant biofilms. Vitamin D plays a biologically significant role in oral host defense through regulation of the epithelial barrier, induction of antimicrobial peptides, immune modulation, inflammatory control, and mineral metabolism. However, the extent to which vitamin D modifies the SSB -oral microbiome -disease pathway in humans remains unclear.

Methods: This narrative-conceptual review employed structured evidence mapping. Relevant literature was identified through PubMed/MEDLINE, Scopus, and Web of Science Core Collection, with additional sources obtained via citation …

Jpmorgan Chase Bank, N.A. V. Smith

All Decisions

In this debt collection lawsuit, the defendant defaulted and moved to vacate the judgment and interpose an answer denying proper service. At the traverse hearing, the plaintiff's process server failed to testify credibly about service. Specifically, there was a dispute about whether the door she allegedly affixed the documents to was the door to defendant's apartment, and the description in her affidavit did not match the photograph defendant submitted into evidence. The process server also only attempted service when defendant was at work and failed to bring her logbook or any other paper or electronic records to support her testimony. …

Translational Reading Frame Predicts The Pathogenicity Of C-Terminal Frameshift Deletions In Mecp2, Jacky Guy, Elena Hein, Beatrice Alexander-Howden, Timur Von Bock Und Polach, Tricia Mathieson, Benjamin P Kleinstiver, Huda Y Zoghbi, Adrian Bird

Duncan NRI Faculty and Staff Publications

Mutations in the MECP2 gene cause the severe neurological disorder Rett syndrome. A cluster of frameshift-causing C-terminal deletions (CTDs) removes ~100 amino acids and accounts for approximately 10% of RTT-causing mutations. Their pathogenicity is unexpected because this C-terminal domain is dispensable in mice. Analysis of pathogenic and benign human MECP2 variants reveals that some individuals with apparently typical CTDs do not develop Rett syndrome, confirming that C-terminal truncations are not intrinsically pathogenic. Using human sequence data and mouse models we show that pathogenicity results from a marked reduction in MeCP2 levels and depends on the presence of a proline proline …

Cigarette Smoke Induces Fasn-Dependent Fatty Acid Metabolic Rewiring To Drive Bladder Cancer Progression, Chandra Sekhar Amara, Danthasinghe Waduge Badrajee Piyarathna, Abu Hena Mostafa Kamal, Yuen San Chan, Karthik Reddy Kami Reddy, Chandra Shekar R Ambati, Mohammed Khurshidul Hassan, Pratik Shriwas, Tanmay Gandhi, Antrix Jain, Tanja Gangnus, Pooja Popli, Roshan Borkar, Sung Wook Kang, Silvia L Summers, Vasanta Putluri, Sandra L Grimm, Sharan Venkatesh, Ningxin Song, Erin H Seeley, Jenna Hedlich-Dwyer, Shu-Hsia Chen, Nupam P Mahajan, Abhinav K Jain, Lacey Elizabeth Dobrolecki, Gabrielle A Wells, Hugo Villanueva, Jenny Li, Xuefeng Liu, Roni J Bollag, Anna Malovannaya, Sung Yun Jung, Hyun-Sung Lee, Irfan A Asangani, Martha K Terris, Chad J Creighton, Leomar Y Ballester, Balasubramanyam Karanam, Suyu Liu, Minjae Lee, Rajeeva R Raju, M Minhaj Siddiqui, Livia S Eberlin, Ramakrishna Kommagani, Arun Sreekumar, Jianjun Gao, Nicolas L Young, H Courtney Hodges, Cristian Coarfa, Natalie R Gassman, Seth P Lerner, Yair Lotan, Nagireddy Putluri

Faculty, Staff and Students Publications

Cigarette smoke promotes bladder tumor growth by enhancing cancer cell survival and proliferation through smoke mediated carcinogens. FASN, a key enzyme in fatty acid synthesis, is dysregulated in many cancers and correlates with aggressive phenotypes. In this study, we demonstrate elevated fatty acid levels and FASN specifically in smokers with bladder cancer. Elevated FASN under smoke exposure imparted epigenetic alterations, particularly histone acetylation, impacts DNA repair and DNA-binding transcription factors which regulate metabolic pathways. Under cigarette smoke, bladder cancer cells undergo a metabolic shift, utilizing glutamine as a major carbon source through reductive carboxylation to fuel fatty acid biosynthesis via …

Measuring The Tokenization Premium: A Cost Audit For Underserved Language Communities, Avijit Roy, Proma Roy, Hrishitva Patel

Publications and Research

Large language models are increasingly deployed as general-purpose educational and technical assistance systems, but their basic infrastructure does not treat languages equally. One underexamined source of disparity is tokenization: semantically equivalent content can require substantially different token counts across languages, affecting API cost, latency, and usable context length before a model is even invoked. We introduce the Tokenization Equity Audit (TEA), a reproducible benchmark for measuring tokenization premiums in technical tutoring content. TEA evaluates three widely used tokenizers, GPT-4o’s o200k base, Qwen2.5-7B, and Mistral-7B, on a 120-item Python debugging corpus translated from English into Bengali, Hindi, Arabic, Tamil, and Yoruba. …

Cardinal Vices In Middle-Earth (2025), By Martina Juričková, John Wm. Houghton

Journal of Tolkien Research

Book review, by John Wm. Houghton, of Cardinal Vices in Middle-earth (2025), by Martina Juričková.

Effects Of Microalgae Supplementation On Broiler Meat Quality, Antioxidant Status, And Fatty Acid Profile, Ebrar Filizoğlu, Özlem Karadağoğlu

The Thai Journal of Veterinary Medicine

This study aimed to evaluate the dose-dependent effects of dietary supplementation with Schizochytrium limacinum, a microalga rich in omega-3 fatty acids and bioactive compounds, on the fatty acid composition and antioxidant status of broiler breast meat, as well as its potential effects on growth performance, carcass characteristics, and meat quality. In a 42-day feeding trial, 192 day-old Ross-308 broiler chicks were randomly allocated to four dietary treatment groups (48 chicks per group): a control group fed the basal diet without S. limacinum supplementation (0 g/kg), and three treatment groups fed the basal diet supplemented with 0.25, 0.5, and 1 …