Digital Commons Network^™

The Impact Of Congenital Heart Disease On The Timing Of Alzheimer's Disease In Down Syndrome, Julianne G. Clina, Brian C. Helsel, Sigan L. Hartley, David A. White, Victoria L. Fleming-Batayneh, Benjamin Handen, Bradley Christian, Elizabeth Head, Mark Mapstone, Christy L. Hom, Beau Ances, Jeffrey Burns, H. Diana Rosas, Florence Lai, Sharon Krinsky Mchale, Joseph H. Lee, Frederick A. Schmitt, Jordan Harp, Ira T. Lott, Shahid Zaman, Lauren T. Ptomey

Neurology Faculty Publications

INTRODUCTION: The incidence of Alzheimer's disease (AD) in Down syndrome (DS) exceeds 90%. Approximately 50% of people with DS have congenital heart disease (CHD). Having CHD increases risk for early-onset AD in populations without DS, but it is unclear if CHD influences AD in DS. METHODS: Data from the Alzheimer Biomarker Consortium-Down Syndrome (ABC-DS) were used. Participants with CHD (n = 82, mean age = 39.9 ± 8.5 years, 97.6% White race) were age- and sex-matched to participants without CHD (n = 82, mean age = 40.5 ± 8.1 years, 98.8% White race). Cognitive assessments and Centiloid load (CL) (positron …

Hyperacute Interleukin-1Β Production And Neutrophil Extracellular Trap Formation In The Cerebral Circulation Of Stroke Patients With Large Vessel Occlusion, Justine Münsterberg, Caspar Brekenfeld, Hanna Englert, Marius Piepke, Regine J. Dress, Martin Oertel, Tina Fischer, Romy Hackbusch, Mingming Zha, Haodi Cai, Christian Casar, Ines S. Schädlich, Leo Winter, Alina Jander, Karoline Degenhardt, Maxim Bester, Fabian Flottmann, Uta Hanning, Brigitte Holst, Anna Worthman, Johanna Hiefner, Berenike Rutz, Eckhard Schlemm, Götz Thomalla, Bettina H. Clausen, Ann M. Stowe, Immo Prinz, Thiruma V. Arumugam, Markus Glatzel, Thomas Renné, Jens Fiehler, Eva Tolosa

Neurology Faculty Publications

Objective: Cerebral ischemia remains a major cause of disability, and the contribution of the hyperacute immune response is increasingly recognized. The aim of this study was to investigate the local inflammatory response in the affected brain of stroke patients with large vessel occlusion during the hyperacute phase of stroke. Methods: To decipher the role of myeloid immune cells in stroke-induced inflammation, we performed an unsupervised multiomics analysis of innate immune pathways in ischemic blood obtained directly from the occluded middle cerebral artery in 54 patients undergoing mechanical recanalization. Paired nonischemic arterial blood served as an internal control. Results: Stroke triggered …

Decoding The Human Pbmc Isonome, Patricia Hayes Doyle, Madeline L. Page, J. Anthony Brandon, Bernardo Aguzzoli Heberle, Brendan J. White, Ann Marie Stowe, Mark T.W. Ebbert

Neurology Faculty Publications

Long-read single-cell RNA sequencing provides an opportunity to understand human health and disease at a level difficult to resolve with bulk or short-read methods. This approach enables isoform-level investigation of cellular diversity and disease mechanisms and definition of cell-types, rather than using genes alone. Using a modified, microfluidic-free PIPseq workflow and computational pipeline adapted for Oxford Nanopore long-read sequencing, we generated the largest long-read single-cell dataset of human peripheral blood mononuclear cells (PBMCs) from a single donor to date, the first with sufficient cell numbers to detect megakaryocytes. This study profiled isoform usage across immune cells, integrating marker expression and …

A 1d Symmetric Interior Penalty Discontinuous Galerkin Solver In Rust, William Aey

Williams Honors College, Honors Research Projects

This honors project will build a 1D Symmetric Interior Discontinuous Galerkin (SIPDG) solver in Rust for Stum-Liouville type problems such as the Poisson equation, with Robin, Dirichlet, and Neumann boundary conditions. The work will cover the full pipeline: starting from the strong form of the PDE, deriving the DG weak form, implementing element and interface operators, and assembling or apply the discrete operator. Rust's safety and concurrency (e.g, via Rayon) will be used to explore serial and parallel performance. A test-driven development approach will be used to maintain a strong suite of tests. The project will result in a documented …

Determining Critical Micelle Concentrations Of Standard Surfactants And Rhamnolipids, Kathryn E. Kunz

Williams Honors College, Honors Research Projects

My proposed project will study the critical micelle concentration (CMC) of rhamnolipids using the pendant-drop and drop-weight methods. First, the critical micelle concentrations of ionic and nonionic common surfactants will be tested. Sodium Dodecyl Sulfate (SDS) will be used as an ionic surfactant and Tween 20 will be used as a nonionic surfactant. The critical micelle concentrations will be determined using the pendant-drop and drop-weight methods. The experimental results from the standard surfactants compared to their accepted values will be tested to assist with determining a more suitable approach. Completing the tests will provide a better understanding of critical micelle …

Ai-Based Porosity Detection In Babbitt Bore Turning, Kaylee Leggett, Hannah Adams Gemmell, Kaisa Shingleton

Williams Honors College, Honors Research Projects

For this project, an external company reached out to the University of Akron requesting assistance with defect detection during their vertical turning operations. As babbitt is removed in a vertical turning process, it occasionally reveals defects, mainly porosity, which can lead to costly downstream failures of the part. Current inspection techniques involve use of dye penetrant, which is time consuming, labor intensive, unergonomic, and a source of human error. The goal of the project is to create an alternative inspection method using an AI-based machine-learning model. After the turning operation, a camera is deployed to perform an in-place inspection, taking …

Design New Stage For Vacuum Pin On Disk, Miranda Boyd

Williams Honors College, Honors Research Projects

For my senior design project, I am redesigning the moving stage for the vacuum pin-on-disk test used in the Akron Engineering Tribology Lab. This system is used to evaluate bearings and lubricants for aerospace applications under controlled vacuum conditions. The current stage design limits flexibility when adjusting for different testing parameters, so my goal is to develop a new movable stage that allows for varying weights and loads to be applied accurately and safely. The redesigned stage will improve test efficiency, adaptability, and precision, ensuring the system can accommodate a wider range of experimental conditions and materials while maintaining compatibility …

Printer For Music Box, Chad Lewis, Caleb Murawski, Zion Smith, Bryan Tibbs

Williams Honors College, Honors Research Projects

The traditional method of creating music box sheet music involves manually punching holes into a paper strip using a hand-operated hole punch. This process involves precise knowledge of each note’s location and the ability to achieve perfect accuracy for hours.

The goal of this system is to automate this process, significantly reducing the time required while greatly improving the accuracy of the resulting music box playback. The user simply uploads a MIDI file of their choice into a user-friendly application. Here, the file is modified based on the user’s needs and sent to an automated hole-punching system to punch the …

Crashheart, Ellie Riekert, Kennady Skidmore, Madison Furino

Williams Honors College, Honors Research Projects

This project aims to develop an XR (extended reality) iPad training system to improve pediatric crash cart preparedness among nurses and clinical staff at Akron Children’s Hospital. In emergencies such as respiratory failure or shock, quick and accurate access to crash cart supplies is vital, yet opportunities for hands-on practice are limited. Current nurse training relies on PowerPoint instruction or costly physical simulations, reducing engagement and skill retention. Our interactive XR solution replicates the crash cart’s layout and contents, allowing users to practice identifying and retrieving critical items in a realistic environment without using physical supplies. The system will be …

Seat Belt Data Collection Methods: A Comparison Between States And National Guidelines, Madison R A Richards

Williams Honors College, Honors Research Projects

Thousands of fatalities related to vehicle crashes occur every year. One method to reduce fatalities is to encourage seat belt use compliance. To promote statistics regarding seat belt use, there first must be reliable data on seat belt compliance and this comes from good survey design.

This report is a comparative analysis of seat belt data collection methodologies for Ohio, Michigan, and Indiana, in addition to an evaluation of how each state aligns with standards set by the National Highway Traffic Safety Administration (NHTSA). The framework for this analysis focuses on NHTSA’s five core survey design requirements: selection of observation …

Supporting Mothers Within The Criminal Legal System: Programs In Akron And Perceptions Of “Good Motherhood”, Brynn R. Lewis

Williams Honors College, Honors Research Projects

This paper examines the programs and support systems available in Akron, Ohio, for mothers involved in the criminal legal system, including defendants, survivors, and other justice-involved individuals. Using qualitative interviews (n = 6) with professionals across courts, legal defense, community corrections, and advocacy organizations, this study examines how local institutions provide resources and support to mothers. Findings indicate that while programs aim to promote stability and rehabilitation, mothers face persistent barriers such as limited access to transportation, childcare, and communication, as well as heightened stigma tied to societal expectations of caregiving. These findings reveal that institutional support both reflects and …

Security Onion Ids Case Study: Detecting And Investigating Threat Traffic Using Suricata, Zeek, And Pcap Evidence, Daryna Myroniuk

Williams Honors College, Honors Research Projects

A key component of cybersecurity is network intrusion detection, which is used to examine network traffic for any malicious activity. Many organizations deploy intrusion detection systems (IDS) but still face challenges such as validating detections, investigating alerts in a timely manner, and producing clear and repeatable evidence of what has occurred, especially when live traffic capture may be limited to risks, permissions, or privacy concerns. The goal of this project was to use Security Onion, which includes Suricata and Zeek to create and demonstrate a controllable and manageable evidence-based IDS investigation workflow. This project is focused on deploying and validating …

Stanislavski And Operatic Acting: What Caused The Divide Between Stanislavski’S Ideals And The Opera World?, Max Smith

Williams Honors College, Honors Research Projects

There is a difference between the realism of acting in opera and in other theatrical art forms. One reason for this might be due to theatre practitioner Konstantin Stanislavski’s ideals not being readily adopted in the opera world. Due to translation and publication issues in both the West and in the USSR, his work on opera has been largely neglected by theatre and opera historians. Certain demands of opera as an art form limit or make more difficult the ability for realism in portraying a character, but Stanislavski and others show that it is possible. A look at literature reflecting …

Defending A Soho Network Against Mitm Attacks, Braeden J. Wise

Williams Honors College, Honors Research Projects

Cybersecurity is a vast domain that consists of many threats that target sensitive information found on wired and wireless networks. One of those threats is a man-in-the-middle (MITM) attack, which involves an attacker situating themselves between a sender and a receiver to intercept or redirect network traffic. These kinds of attacks can run rampant on a small office home office (SOHO) network due to the vulnerabilities and lack of enterprise level tools. The intent of this project is to perform and defend against MITM attacks for a SOHO network. In the context of the project, three MITM attacks will be …

Rapid Skin Stapler, Emma J. Patterson, Allison M. Milligan, Morgan E. Dunlap

Williams Honors College, Honors Research Projects

Severe burn injuries frequently require split-thickness skin grafts, with metal surgical staples serving as the current standard for fixation. While staples provide rapid and secure placement of graft material, they also introduce significant challenges. Removal is painful, time-consuming, and often requires sedation in pediatric patients, leading to added risk, resource strain, and poor patient experience. These drawbacks highlight the need for improved fixation methods that maintain graft stability while reducing procedural burden. This project applies the engineering design process to address these challenges through identification of user needs, translation into design inputs, risk assessment, and development of a prototype aimed …

The Effect Of Minimum Wage On Household Debts And Delinquencies, Payton G. Rader

Williams Honors College, Honors Research Projects

This paper examines how increases in binding minimum wages affect various types of household debts and delinquency rates. Within this paper, household debt is defined as the combined sum of auto loans, credit card debt, mortgage debt, and student loan debt. The goal of the analysis is to conclude whether minimum wage increases are contributing to America’s growing debt crisis. The answer to this question likely relies on whether or not minimum wage increases cause unemployment. This is because unemployment can contribute significantly to debt levels when unemployed people rely on credit for day-to-day transactions or payments. Traditional economic theory …

A Decade Of Programming Languages: Trends In Popularity And Influence, Jonathan C. Erb

Williams Honors College, Honors Research Projects

Programming languages play a central role in open-source software ecosystems, yet their adoption, visibility, and influence shift over time as technologies, developer communities, and industry practices evolve. The study aims to investigate long-term trends in programming-language usage on GitHub from 2014 through 2024, focusing on ten major languages that represent diverse domains and ecosystems. Using repository metadata, engagement metrics such as stars and forks, and language-level code statistics measured with cloc, the analysis will examine changes in repository creation, code contribution volume, and popularity. Since popularity remains an unsettled and multidimensional concept, part of this research involves determining how it …

Reconstructing Lost Voices, Lana Tamim

Williams Honors College, Honors Research Projects

This project uses digital text mining tools (OCR, NLP, sentiment analysis, and topic modeling) to analyze 19th–20th-century newspaper archives, focusing on how marginalized groups (women, immigrants, or labor workers) were historically portrayed. Many historical newspapers were dominated by elite voices, so this project aims to recover silenced or misrepresented perspectives by identifying hidden patterns in language, frequency of coverage, sentiment, and shifts in public perception over time. Using machine learning and visualization tools, the project will create interactive maps and timelines showing how representation evolved across regions.

Lunar Regolith Densometer, Liam Lee, Vincent Innocenzi

Williams Honors College, Honors Research Projects

Testing of extraterrestrial rovers is a growing concern as lunar exploration as an industry is becoming increasingly commercialized. Currently, the way rover testing is conducted is on a soil regolith which is already available. The structure of the soil, however, is harmful to humans and requires a full bunny suit and respirator to be worn during the conduction of the experiment. This limitation, along with the expensive price tag, prevents college university students and companies from establishing a rover test area in labs. The goal of the overall project is to create a safer testing environment by mimicking the soil-to-tire …

Redrawing Anatomy: Addressing Female Genital Underrepresentation In Educational Texts, Clara E. Krohn

Williams Honors College, Honors Research Projects

The fight for female equality in the historically male dominated medical field is an ongoing battle. This project focuses primarily on the underrepresentation of female genitalia in undergraduate academic textbooks. A dissected pelvis of a female cadaver was initially examined. Pictures were obtained with scale bars to accurately depict size of the structures included. Underrepresented structures such as the clitoris and the broad ligament were closely examined along with the reproductive system as a whole. The pictures compiled along with further research were used to design a portfolio of diagrams and a survey to be later administered. The survey was …

Expanding State Tax Authority: Public And Private Sector Impacts Of Wayfair, Maxwell Pastoria

Williams Honors College, Honors Research Projects

The 2018 Supreme Court decision in South Dakota v. Wayfair, Inc. (Wayfair) overturned the longstanding physical presence rule for state sales tax collection, enabling states to enforce tax obligations on remote sellers through marketplace facilitator and economic nexus laws (Oyez, 2018). This study investigates the effects of these two post-Wayfair tax laws on state sales tax revenues, entrepreneurship, and public expenditures across all 50 states. Using a two-way fixed effects difference-in-differences (TWFE DID) framework, this research analyzes how policy adoption influenced per-capita outcomes in tax revenue, firm formation, and government spending in social services, education, infrastructure, and …

Codezip: A University-Based Coding Practice And Collaboration Platform, Manoj Khatri

Williams Honors College, Honors Research Projects

This project proposes the development of CodeZip, a university-exclusive web platform designed to help University of Akron students practice coding problems, prepare for technical interviews, and engage in collaborative learning. CodeZip ensures a secure environment by restricting access to users with @uakron.edu email addresses via Clerk API authentication.

The goal of this honors project is to expand CodeZip into an intelligent, interactive system. Planned enhancements include AI-generated problem hints, automated grading with performance analytics, and a visual dashboard to track learning progress. These features will provide personalized guidance, encourage collaboration between students and alumni, and create a dynamic platform that …

Locked In: The High Price Of Overcrowding And The Strain Of America's Growing Prison System, Kaitlyn N. Timmerman

Williams Honors College, Honors Research Projects

Over the past several decades, the number of people incarcerated in the United States has increased substantially, placing a significant strain on correctional systems. This project examines long-term trends in incarceration to better understand how population growth may relate to concerns about overcrowding. Specifically, it asks: How has the total incarcerated population in the United States changed from 1925 to 2022? Which type of correctional system (state prisons, federal prisons, or local jails) has experienced the most growth? And to what extent can changes in incarceration counts and facility distribution be used as indicators of overcrowding?

Using historical data and …

Ai-Based Music Mood Analysis With Historical And Real-Time Data, Biswash Bhattarai

Williams Honors College, Honors Research Projects

The Music Mood Analyzer Dashboard identifies and visualizes the emotional tone of songs using audio features like tempo, energy, and valence. It classifies tracks into moods such as happy, sad, or calm and presents insights through an interactive dashboard. The project combines music analysis and data visualization to help users understand how sound relates to emotion.

Simplified Traffic Studies For Local Agencies, Laura Slusher

Indiana Local Technical Assistance Program (LTAP) Publications

Traffic studies are critical in the decision-making process for many transportation-related projects, funding requests, paving and plowing priorities, and in reporting to elected officials and the public. It is often difficult for local jurisdictions with limited equipment, staff, and time to perform these studies or have the funds available to hire them out. This handbook describes simplified procedures that are easy to apply and are written for all potential users.

Cav Pilot Development And Deployment In Midwest Winter, Yupeng Zhou, Can Cui, Zichong Yang, Juntong Peng, Ziran Wang

Center for Connected and Automated Transportation

This project addresses the critical challenges of deploying Connected and Automated Vehicles (CAVs) in adverse Midwest winter conditions by developing a novel hierarchical framework that integrates Large Vision-Language Models for robust, context-aware decision-making. Real-world pilot experiments demonstrate that this architecture significantly enhances vehicle safety and personalization, effectively translating abstract human commands into precise control adjustments on low-friction, snow-covered surfaces. Furthermore, a specialized high-fidelity dataset capturing unique environmental edge cases was established to bridge the domain gap in existing resources and support the future development of resilient all-weather autonomous technologies.

Breech Baby, Madison Kaufman, Cassidy Allen, Lilian Mills

Williams Honors College, Honors Research Projects

Our project aims to develop a non-invasive device to assist in turning breech babies to a head down position before delivery. Pregnant women facing breech presentations often need safe and effective solutions, yet current options like external cephalic version (ECV), maternal positioning techniques, and cesarean sections can present challenges. Key barriers include variability in maternal and fetal anatomy, patient comfort, compliance, and training for healthcare providers, along with cost and insurance concerns.

Our innovative device will address these issues by providing clear guidance and support throughout the process. It will prioritize minimizing discomfort and risk, ensuring adaptability for various stages …

Bare Bones Creamery/Ice Cream, Hanna Pope, Mason Dexter, Stephen Parker, Evan Trumpower, Logan Miller

Williams Honors College, Honors Research Projects

Essentially, our project focuses on the fictional company, “Bare Bones Creamery.” Bare Bones Creamery is a company that sells all natural, affordable, no nonsense ice cream targeted towards people between the ages of 18 to 40. Our main goal is to document the process to grow and scale this company to 100 employees in about 10 years. Outside of this, we’ll also develop different departments of the company including finance, accounting, supply chain, IT/ data analytics, human resources, legal, sales, and marketing. Each department will grow with the company and will become more detailed as time progresses. Certain variables such …

Nail Salon Appointment Management System., Alexander Tran

Williams Honors College, Honors Research Projects

I will create an appointment management system for my family's nail salon. This will contain a database and tables that keep track of data of the employees, customers, and the receptionist to make it easier to book appointments for the nail salon. This was originally made to create an appointment system because I have family members who don't understand technology well and wanted to make something simple and intuitive for anyone to use, since the appointment system that we currently use is extremely off the cuff, and this should remedy that.

Length Modulatin Hip Implant, Ethan Smith

Williams Honors College, Honors Research Projects

Leg length discrepancy is a well-documented complication of total hip arthroplasty, commonly known as hip replacement surgery. Even small differences in leg length can lead to an altered gait, increased joint stress, and long-term postural issues that may affect a patient’s overall mobility and comfort. The current method for correcting this discrepancy often involves a follow-up surgical procedure, which extends recovery time and increases the physical and financial burden on the patient. To address these shortcomings, we developed a concept for an adjustable hip implant that can be lengthened noninvasively after surgery. The design incorporates an internally housed battery and …