Digital Commons Network^™

Optimizing Control Definitions In Opioid Use Disorder Genetic Research Using Electronic Health Records, Maria Niarchou, Ellen L Tsai, Mariela V Jennings, Annika Faucon, Hyunjoon Lee, Kritika Singh, Justin D Tubbs, Panos Roussos, Tian Ge, Richard C Crist, Rachel Vickers-Smith, Howard Edenberg, Amy Moore, Bradley T Webb, Eric O Johnson, Rachel L Kember, Jordan W Smoller, Lea K Davis, Brandon J Coombes, Georgios Voloudakis, David Burstein, Travis T Mallard, Vanessa Troiani, Sandra Sanchez-Roige

Epidemiology and Environmental Health Faculty Publications

Amidst the opioid crisis, understanding the genetic basis of opioid use disorder (OUD) is crucial for identifying biological mechanisms and intervention points. However, genome-wide association studies (GWASs) have been hampered by inadequate sample sizes and often the use of control populations not assessed for prior opioid exposure. Because opioid exposure is a prerequisite for the development of OUD, consideration of exposure history in controls is important. Electronic health record data (EHR) paired with genomic information allow a broader sampling of patients with OUD and exposed controls. We leveraged data across two healthcare systems to evaluate the impact of using controls …

Building The Ryan White Hiv/Aids Program Bench In Kentucky, Lauren Bifulco, Kathleen Harding, Jana Collins, Anna Rogers, Lenon Farkash, Marwan Haddad, Alice Thornton

Epidemiology and Environmental Health Faculty Publications

The Ryan White HIV/AIDS program (RWHAP) is governed by legislative and programmatic guidelines that ensure comprehensive services are provided to persons with HIV (PWH) across the United States. Comprehensive training and skill building opportunities for programmatic staff are rare. RWHAP funding recipient organizations may struggle to acquire and retain essential program-specific knowledge, with downstream impact on patient care and treatment. We designed a comprehensive 11-session videoconference learning series to improve program staff’s confidence and competence with RWHAP fundamentals. Quantitative pre-vs-post session data were analyzed using Wilcoxon Signed-Rank tests, and qualitative data using thematic analysis. We enrolled 136 staff from 23 …

Metabolic Reprogramming Following Mitochondrial Transfer Between Idh2-Mutant Chondrosarcoma Cells And A Normal B-Cell Line, Caleb Wyckoff, Christopher Osgood, Ellen Jing, Michael Stacey

Bioelectrics Publications

Background/Objectives: Chondrosarcoma, glioblastoma, acute myeloid leukemia, chronic lymphocytic leukemia, and cholangiocarcinoma cancers all contain mutations in the gene isocitrate dehydrogenase 2 (IDH2). The mutant IDH2 enzyme metabolizes alpha-ketoglutarate (αKG) into the potent oncometabolite D-2-hydroxyglutarate (D2HG) in the mitochondria of these cancers, leading to altered cellular metabolism. Emerging evidence suggests that mitochondrial transfer between cancer and recipient cells represents an important form of intercellular communication that may influence cellular metabolism. The presence of intercellular TNTs between IDH2-mutant chondrosarcoma cells motivated an investigation into mitochondria-associated physiological changes occurring during an intercellular exchange with immune cells. A mitochondrial transfer is a two-way …

Cxcr6+ Natural Killer Cell Immunotherapy Preserves Cd4+ T Helper Cells In Humanized Mice, Naushad Khan, Kayla Frank, Silke Paust

Faculty Research 2026

Human immunodeficiency virus (HIV) persists despite antiretroviral therapy because long-lived viral reservoirs are not eliminated, and ongoing or rebound infection contributes to progressive loss of CD4⁺ T helper cells. Natural killer (NK) cells can acquire adaptive, antigen-experienced functions, including recall responses to HIV envelope protein, suggesting that defined NK-cell subsets may be therapeutically useful against HIV. Because HIV-responsive adaptive NK-cell activity is enriched among CXC chemokine receptor 6-positive (CXCR6⁺) NK cells, we tested whether CXCR6⁺ NK cells provide enhanced antiviral activity and CD4⁺ T-cell protection compared with CXCR6⁻ NK cells. In co-cultures with HIV-infected …

Short Term Trends In Benthic Macroinvertebrate Communities Downstream Of Iron Gate Dam Before And During Klamath Dam Removal, Rosa Cox

Cal Poly Humboldt theses and projects

Dam removals are increasingly being used to restore connectivity and ecological function to rivers degraded by impoundments, yet the short-term ecological impacts of large-scale dam removals remain poorly understood. In 2023-2024, four hydroelectric dams were removed from the Klamath River in Northern California and southern Oregon, mobilizing large volumes of fine sediments stored in reservoirs.  This study evaluated short-term trends in benthic macroinvertebrate (BMI) communities within the first ~90 km downstream of the Klamath dam removal project reach by comparing benthic kick net, invertebrate drift, and juvenile salmonid diet samples before (2022-2023) and during (2024) dam removal at paired mainstem …

Bacterial Community Function In Pitcher Plant Leaves As An Experimental And Mathematical Model Of Functional Dynamics, Amelia Jackson

Cal Poly Humboldt theses and projects

This work looks at two different sites with differing abiotic factors in measures of altitude, temperature and precipitation. The site with higher altitude, larger temperature range, and lower precipitation, located in Plumas National Forest (Quincy, CA), had a flat BEF trend that suggests functional redundancy The site with lower altitude, more moderate temperatures, and higher precipitation located in Six Rivers National Forest (Gasquet, CA), also had a flat BEF trend. These abiotic factors could correlate to the significantly different bacterial compositions between sites. The second portion of this work is modeling the host antagonist relationship between Eyxra moths and their …

Reward Deficits In Co-Occurring Social Anxiety And Depression: The Roles Of Anhedonia, Boredom, Loneliness, And Covid-19 Social Restriction, Nathan M. Hager, Alicia L. Milam, Hannah C. Hamrick, Benjamin Swanson, Matt R. Judah

Psychology Faculty Publications

Prior research points toward reward deficits as crucial to the link between social anxiety disorder and major depressive disorder. However, studies have not explored specific types of reward deficits or how social-environmental factors may impact them. The current study examined whether the indirect effects of three reward deficits (anhedonia, boredom, and loneliness) accounted for the connection between social anxiety and depression. Questionnaires were collected in a sample of college students (N = 523) during the first year of the COVID-19 pandemic, allowing examination of environmental stressors (i.e., remote learning and current friend network size) on reward deficits. Indirect effect models …

Ai Deployment Authorisation: A Global Standard For Machine-Readable Governance Of High-Risk Artificial Intelligence, Daniel Djan Saparning

Student Publications

Modern artificial intelligence (AI) governance lacks a formal, enforceable mechanism for determining whether a given AI system is legally permitted to operate in a specific domain and jurisdiction. Existing approaches-such as model cards, audits, and benchmark evaluations provide descriptive information about model behaviour and training data but do not produce binding deployment decisions with legal or financial force. This paper introduces the AI Deployment Authorisation Score (ADAS). This machine-readable, regulator-grade framework evaluates AI systems across five legally and economically grounded dimensions: Risk, Alignment, Externality, Control, and Auditability, derived from safety engineering, alignment theory, algorithmic accountability, and liability economics. ADAS produces …

2025 Annual Report Of The Officers, Town Of Orange, New Hampshire, Orange Town Representatives

Orange, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

Town Of Harrisville, Nh Annual Report For The Year Ending December 31, 2025, Harrisville Town Representatives

Harrisville, NH Annual Reports

This is an annual report containing vital statistics for a town/city in the state of New Hampshire.

“… It's Google That's Big Brother”: The Symbiosis Between Icac Investigators And The Private Sector Regarding Encryption And Privacy, Christopher G. Brewer, Kevin F. Steinmetz, Don Kurtz, Brian Schaefer

Faculty Publications - Criminal Justice Sciences

Encryption technologies have become ubiquitous for both individual and commercial sectors. Perhaps no realm of law enforcement is so acutely affected by encryption than cybercrime, including internet crimes against children (ICAC) personnel. There exist a variety of encryption-based tools and authentication measures available to help online child sexual abusers and consumers of child sexual abuse material (CSAM) hide their activities and obstruct law enforcement efforts to gather evidence of criminal activity. Established here is the idea that ICAC investigative practice is ultimately shaped by these technologies as well as the relationship between the distributors of these technologies and private platforms …

Giddy Character Rig, Arden Jean Millhouse-Lewis

Senior Honors Theses and Projects

This project was an in-depth investigation into creating a production-ready rig using the widely used industry-standard software, Autodesk Maya. Using a character I designed, modeled, and shaded, I explored the workflow of bringing it to life through the technical lens of rigging, then tested its functionality in animation, troubleshooting, and further refining the overall rig as I went. I revised the prior model’s topology to create optimal edge flow for deformations before I went on to place it in the skeletal hierarchy, accounting for not only the bones of the character but also secondary bones in the clothing, hair, and …

Investigating The Effects Of Atg3 On Autophagosome Size And Number, Keeran R. Senthil Kumar

Senior Honors Theses and Projects

Macroautophagy, or autophagy, is a highly conserved catabolic process in all eukaryotes which allows for the degradation of large cytosolic contents. It occurs in two forms: bulk autophagy, which is induced by nutrient deprivation and targets nonspecific cargo, and selective autophagy, which is induced by cellular stress and sequesters specific substrates. The process of autophagosome formation is carried out by a group of Atg (autophagy-related) proteins, one of which is Atg3. Atg3 functions as an E2-like enzyme by conjugating Atg8 — a ubiquitin-like protein — to phosphatidylethanolamine (PE), a step required for autophagosome membrane formation. This lipidation process is catalyzed …

Oligarchy And Democratic Decline: A Platonic Framework For Analyzing The Contemporary American Political System, Jonah Huskey-Wright

Senior Honors Theses and Projects

This paper explores the idea that there is a meaningful philosophical connection between Plato’s account of oligarchy and the development of the modern American political order. Rather than approaching American politics only through constitutional design, electoral procedures, or institutional mechanics, the paper argues that political systems must also be understood as reflections of the values and motivations of the people who inhabit them. Drawing on Plato’s framework that links the ordering of the human soul to the ordering of political regimes, the project examines how the priorities a society places on certain goods—particularly wealth, economic achievement, and material success—can shape …

Enhancing Healthcare Accessibility For Maya Immigrants In Northeast Ohio, Ellen D. Barnes

Senior Honors Theses and Projects

This research considers the efforts of healthcare practitioners and community workers in enhancing healthcare accessibility for Maya immigrant communities in northeast Ohio. Through ethnographic interviews and participant-observation research, I analyze how practitioners interpret their work with community members to navigate economic disparities and questions of legal standing, as well as cultural and linguistic differences. I also consider ways in which healthcare providers have sought to promote institutional change. This research gives insight into how institutional structures shape efforts for culturally informed care and how healthcare providers and healthcare seekers negotiate relationships within these confines.

Zero Tolerance Discipline In American Schools: Racial Injustice In The Age Of Youth Disposability, Trinity J. Perkins

Senior Honors Theses and Projects

This study critically examines how neoliberal social controls and school-based criminalization efforts emerged in response to a series of moral panics surrounding perceived increases in school violence and mass shootings. Largely, this response manifested in the form of rigid zerotolerance disciplinary policies focused on deterrence and retribution. However, research reveals the application of these policies produce racial and income-based disparities in how school discipline is administered, which contributes to the school-to-prison pipeline (i.e., a pathway for youth to be funneled out of education and into incarceration). As such, it is believed that racial threat dynamics may be contributing to the …

Efficient Organic Molecular Crystal Structure Prediction Using The Density Functional Tight-Binding Method, Maureen M. Kitheka, Yan Jing, Yan Yao, Puja Goyal

Faculty Publications – Chemistry

Over the years, computational crystal structure prediction (CSP) for organic molecules has thrived as an area of research, spanning various scientific disciplines and having significant applications in industries such as pharmaceuticals and agrochemicals. Within the field of batteries, redox-active organic materials (ROMs) such as quinones have received increased attention as promising electrode materials for rechargeable batteries. However, experimental determination of the crystal structure of intermediate species formed during the discharge/charge cycle can often be challenging. Incomplete X-ray diffraction patterns can also lead to difficulties in crystal structure determination for ROMs used in batteries. Use of a semiempirical electronic structure method …

Seasonal And Lunar Patterns Of Peach Blossom Jellyfish (Craspedacusta Sowerbii) In Michigan, Claire Kozal

Master's Theses and Doctoral Dissertations

The peach blossom jellyfish (Craspedacusta sowerbii) is the only freshwater medusa found in the United States, yet its distribution, abundance, and mechanisms of dispersal remain poorly understood. Given its uncertain status, understanding the ecology of this species is a priority. To characterize population dynamics during the medusa season, surface water temperature and medusa abundance were surveyed at six inland lakes in Michigan. Occurrence records of C. sowerbii in Michigan were then used to compare co-occurrence patterns with nine aquatic invasives as a window into potential dispersal mechanisms and to create a regional ecological niche model. Medusae were observed in one …

The Trial Of Socrates, Jonathan Van Patten

Faculty Publications

In many important ways, the trial of Socrates was not just the trial of the century, nor even the trial of the millennium. It predated the trial of Jesus, which is important for many other reasons, but Socrates’ contribution to how we think about justice and the rule of law is without equal. This Article explores the ways that this fifth-century B.C. trial, located geographically on the margin of what came to be known as the West, is at the center of what makes us a civilization. It is not simply about the drama, nor the politics of free inquiry, …

I And Ai: Human Personhood In An Age Of Artificial Intelligence, Jonathan A. Powers, Daniel H. Strait

Academic Books

No abstract provided.

Detecting And Repairing Conflicting Constraints In Co-Trained Physics-Informed Neural Networks For Composite Curing Processes, Cooper J. Evans

Dissertations, Master's Theses and Master's Reports

Composite materials have become a critical component of modern manufacturing, especially in the automotive and aerospace industries. The curing process for these composites has been modeled using a variety of partial differential equations representing the heat transfer and composite curing kinetics. Optimizing the applied temperature profile is critical for maximizing the efficiency and capacity of composite part manufacturers. Constraints must be placed on the inputs and outputs of the model, including but not limited to, the applied temperature profile, part temperature, and final degree of cure. Conflicting sets of constraints are easy to unknowingly impose due to the highly coupled …

Torque-Based Detection And Isolation Of Bucket-Specific Load Variations In A Continuous Bucket Ladder Excavator, Mason R. Krause

Dissertations, Master's Theses and Master's Reports

Understanding how cutter geometry, material, and operating conditions influence excavation performance is critical for the design of lunar surface systems operating in regolith environments. This work presents a torque-based methodology for detecting and quantifying bucket-specific load variations in a continuous bucket ladder excavator. A nine-bucket excavator was constructed to record drivetrain torque while operating in a regolith simulant over multi-day test periods. Each bucket featured a unique combination of cutting edge material and geometry. A method was developed to separate the continuous torque data into individual excavation events, enabling identification of individual bucket interactions. Analysis of the resulting event-based dataset …

2026 Projects Day Booklet, Seattle University

Projects Day Booklets

No abstract provided.

Catch 23: Putting Superior Back Into The Superiority Prong Of Rule 23(B)(3), Fred B. Burnside

Loyola Consumer Law Review

No abstract provided.

A 725-Bp Quadruple Repeat In The Promoter Of Smmyb113 Is Associated With Light-Independent Anthocyanin Regulation In Eggplant, Zhilei Xia, Meng Yang, Yinggemei Huang, Bingxin Yu, Tingxia Wan, Duanhua Wang, Qian Li, Manoj Sapkota, Shuangshuang Yan, Bihao Cao, Zhengkun Qiu

Horticulture Faculty Publications

Eggplant exhibits a diverse range of fruit colors, making it an excellent model for studying fruit pigmentation and its genetic regulation. While genes responsible for green and photosensitive purple fruit have been identified, the genetic basis of the nonphotosensitive (NPS) fruit trait in eggplant has remained elusive. In this study, we characterized a major quantitative trait locus (QTL), SmNPS10.1, on chromosome 10 using QTL-seq. By combining linkage-based gene mapping with progeny testing, we fine-mapped SmNPS10.1 to a 33.58-kb interval, within which we identified SmMYB113, an R2R3-MYB transcription factor that regulates anthocyanin biosynthesis, as the candidate gene. Sequence analysis …

Adding Family Complications To Birthright Citizenship, Scott Titshaw

Articles

On the first day of his second administration, President Trump issued an executive order purporting to restrict citizenship of U.S.-born children based on their parents’ citizenship or immigration status. In the process, it discriminates between mothers and fathers and adopts genetic definitions of “mother” and “father” to exclude any parent, who is not the child’s “immediate … biological progenitor.”

Courts and scholars have condemned this attempt to restrict birthplace citizenship as a violation of both the Fourteenth Amendment and the Immigration and Nationality Act. Yet there has been little, if any, discussion of the new family-based conditions in the order. …

The Love We Draw, Caleb Van Cleave

English Honors Papers

This thesis contains a completed story about navigating how to continue loving someone after one’s understanding of their being has changed in a way that makes them suddenly unfamiliar. It is a story that asks its characters if they are willing to adjust their perceptions of one another in order to remain connected or if they would rather sacrifice that growth in favor of chasing prior ideals. It is a story about seeking affection but no longer feeling certain of where to find it.

My goal for this thesis was to focus on fragmentation within a family dynamic, specifically during …

“But I’M Glad I’M Not A Hog!”: The Pig, The Laborer & “Humanity” In Animal Farm (1945) & The Jungle (1905), Madelyn Bell

English Honors Papers

This thesis places The Jungle and Animal Farm in conversation with one another to examine how each text engages, reframes, and complicates Marxist conceptions of labor, class, and (de)individuality through the figure of the pig. Beginning from the pig’s marked similarity to humans – its intelligence, sociality, and symbolic proximity – the analysis considers how this likeness makes the pig a particularly charged symbol for negotiating the moral and conceptual boundary between human and animal, inviting a reading in which human structures are reflected back through the animal form. Attending each novel’s distinct concern with socialism – Sinclair’s investment in …

“Us Who Die For You”: Necropolitics Through The Historiography Of Zombies, Kazi Stanton-Thomas

Gender, Sexuality, and Intersectionality Studies Honors Papers

No abstract provided.

Hear & Now: Culturally Responsive Music Education Through Digital Audio Workstations & Musique Concrète, Benjamin T. Connolly

Pitzer Senior Theses

Hear & Now: Culturally Responsive Music Education Through Digital Audio Workstations & Musique Concrète is a two-part ethnomusicological study of how the capacities and affordability of modern electronic instruments could be utilized within school curricula as an affordable alternative to traditional music classes. I explore the musique concrète movement from mid-20th century France, aiming my examination towards the movement’s emphasis on the materiality of sound production and utilization of modern technology during the composition process. From there, the paper transitions into a study on the affordances of contemporary music technologies through a series of interviews with electronic composers, tracing the …