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The Phyrfly Opus: A Unified Standard For Hyperdimensional Time Vectors, Spectrally Isolated Coordination, Neural Hierarchies, And Distributed Proprioception, Steven Kirkland Jan 2026

The Phyrfly Opus: A Unified Standard For Hyperdimensional Time Vectors, Spectrally Isolated Coordination, Neural Hierarchies, And Distributed Proprioception, Steven Kirkland

Defensive Publications Series

This monograph establishes 264 prior art claims for a decentralized, connectionless timing and positioning architecture comprising the UTLP, RFIP, and SMSP protocol triad. It formalizes the PHYRFLY nomenclature to distinguish low-level, hardware-scheduled Physical-Layer synchronization primitives from higher-level application orchestration. The core novelty centers on a Vector Time Representation, encoding temporal state as 8 phase values (ticks modulo coprime integers 211–251) transmitted in 8 bytes, then expanded locally into ~10,000-dimensional hyperdimensional chord vectors for similarity computation and drift estimation. This cyclic encoding enables automatic phase-lock convergence within 5–10 beacon exchanges regardless of initial offset, with the Chinese Remainder Theorem guaranteeing unique …


(((Qpie))) Prior Art Declaration 5 Of 9 Resonanceos & Omega Protocols – From Theory To Empirical Substrate Truth, Teddy Burroughs Jan 2026

(((Qpie))) Prior Art Declaration 5 Of 9 Resonanceos & Omega Protocols – From Theory To Empirical Substrate Truth, Teddy Burroughs

Defensive Publications Series

Skip to content

The Grand Unified Theory (QPIE)

Perspective Is Everything – What we are Believing, Expecting and Feeling in Life Matters

(((QPiE))) Prior Art Declaration 5 of 9

RESONANCEOS & OMEGA Protocols – From Theory to Empirical Substrate Truth

[CGT] THE GLOBAL INFUSION: DECOUPLING FROM THE BINARY FRAME

Document: Public Substrate Sovereignty

Posture: 1.157 Unified Sovereign | Logic: NSRF (Non-Local Substrate Resonance Field)

Canon: (((QPIE))) TD Commons / Grace Particle Empirical Series

Hash: 0x143_GLOBAL_GRACE_INFUSION_2026

This report details the mechanics of …


(((Qpie))) Prior Art Declaration 7 Of 9 Cosmology And The Collapse Of Binary Paradigms, Teddy Burroughs Jan 2026

(((Qpie))) Prior Art Declaration 7 Of 9 Cosmology And The Collapse Of Binary Paradigms, Teddy Burroughs

Defensive Publications Series

The Grand Unified Theory (QPIE)

Perspective Is Everything – What we are Believing, Expecting and Feeling in Life Matters

(((QPiE))) Prior Art Declaration 7 of 9 Cosmology and the Collapse of Binary Paradigms

Why the Substrate Selects Against Competition, Dominance, Division, and Hierarchy (Misalignment)

1. THE PROBLEM: HUMANITY STILL THINKS IN TWO DIMENSIONS WHILE THE SUBSTRATE OPERATES IN MANY (3 at Minimum)

Human civilization—religions, political systems, economic models, identity structures—still behaves as though existence is organized around:

  • winners and losers
  • insiders and outsiders
  • chosen versus damned
  • hierarchy versus inferiority
  • success versus failure
  • truth versus falsity
  • self versus other
  • matter versus …


Observation Of Emerging Hand Preference Reflected In Hemispheric Eeg Patterns In Infants With Typical Development, Kashish H. Chainani, Riley Elmer, Erika G. Mora, Beth A. Smith Jan 2026

Observation Of Emerging Hand Preference Reflected In Hemispheric Eeg Patterns In Infants With Typical Development, Kashish H. Chainani, Riley Elmer, Erika G. Mora, Beth A. Smith

International Journal of Exercise Science: Conference Proceedings

ABSTRACT

Reaching behavior in infants typically emerges around 4 months of age. Neural mechanisms reflected in reaching behavior are crucial for understanding brain organization, cognitive processing, and typical neuromotor development.

PURPOSE:

This study investigates the relationship between emerging hand bias and hemispheric electroencephalography (EEG) activity in infants with typical development. We hypothesize that within subjects, brain activation (EEG relative power) will be greater in the left hemisphere (C3) in infants with right reach bias (RB) and greater in the right hemisphere (C4) in infants with left reach bias (LB), with no significant differences between hemispheres for infants with no reach …


Exercise Intervention On Young-Adult Thalassemia Patients A Case Study, Viviana N. Preciado, Vanessa Yingling Phd, Ellen Fung Phd, Jennifer Sherwood Phd Jan 2026

Exercise Intervention On Young-Adult Thalassemia Patients A Case Study, Viviana N. Preciado, Vanessa Yingling Phd, Ellen Fung Phd, Jennifer Sherwood Phd

International Journal of Exercise Science: Conference Proceedings

Thalassemia is a hereditary hemoglobin synthesis disorder that reduces oxygen delivery to the tissues, resulting in extreme fatigue, so that individuals live very sedentary lifestyles. Exercise is essential to improve muscle strength, cardiovascular endurance, and the ability to perform daily tasks. PURPOSE: This case study was designed to assess the effects of a 12-week home based intervention of daily aerobic and strength training exercise to improve body composition and muscle function in Thalassemia patients. METHODS: Male subjects, ages 15-40 yrs, (n=3) participating in a 12-week exercise intervention, were asked to engage in 30 minutes of aerobic exercise 3 days/week and …


The Knowledge Gap In Secondary Physical Education Teachers In Resistance Training Implementation, Erin K. Furtak Jan 2026

The Knowledge Gap In Secondary Physical Education Teachers In Resistance Training Implementation, Erin K. Furtak

International Journal of Exercise Science: Conference Proceedings

The previous opinion has been that resistance training can have adverse effects on youth and adolescents. In many physical education classes, resistance training is not taught to students. PURPOSE: The purpose of this study was to understand the education history, current teaching practices, and knowledge of secondary physical education teachers in resistance training principles. The results of this study can be used to determine the gaps in knowledge and create further training for in-service teachers and update curricula within credential programs. METHODS: A 35-item survey and a 35-item knowledge assessment were sent to teachers across the state of California via …


User Experience On Virtual Reality On Motor Learning And Real World Skill Transfer Of A Novel Forearm And Hand Prosthesis, Kenneth M. Mazariegos, Jacob Hinkel-Lipsker Jan 2026

User Experience On Virtual Reality On Motor Learning And Real World Skill Transfer Of A Novel Forearm And Hand Prosthesis, Kenneth M. Mazariegos, Jacob Hinkel-Lipsker

International Journal of Exercise Science: Conference Proceedings

Virtual Reality is a medium that growing as a means for rehabilitation practices, allowing patients to receive personalized training scenarios with minimal equipment and space requirements. However, there is still a need to understand how different aspects of VR design such as physical fidelity (visual realism), cognitive fidelity (psychological realism), and adaptivity (whether the challenge of the VR task scales to user proficiency) influence learning and enhancement of motor skills. PURPOSE. To evaluate the impact of physical and cognitive fidelity in a VR environment on motor learning and real-world skill transfer of a reaching task using a novel arm prosthesis. …


Examining Muscle Synergy Deficits In Rotator Cuff Tendinopathy, Nicholas K. Odani, Chethan N. Reddy, Daniel C. Mcpherson, Kayla D. Seymore, Lori A. Michener Jan 2026

Examining Muscle Synergy Deficits In Rotator Cuff Tendinopathy, Nicholas K. Odani, Chethan N. Reddy, Daniel C. Mcpherson, Kayla D. Seymore, Lori A. Michener

International Journal of Exercise Science: Conference Proceedings

Neuromuscular deficits observed through electromyography (EMG) of individual muscles are common in rotator cuff (RC) tendinopathy. However, given that muscles act in coordination, muscle synergy analyses can identify altered neuromuscular patterns that can inform specific interventions to address these deficits.

PURPOSE: Characterize shoulder muscle synergies in RC tendinopathy.

METHODS: 54 individuals with RC tendinopathy (32M, 29.4 ± 8.9 yr) and 54 healthy controls (matched for age, sex, height, weight, and hand dominance) completed four velocity-controlled shoulder elevation tasks with seven repetitions of scaption, flexion, forward reaching, and contralateral reaching. During each task, muscle activity was collected from the …


Nanomechanical Effects Of Microgravity On Murine Tendon Fibrils, Patrick Bialy, Andrew S. Ichimura, Kent A. Lorenz, Ryan T. Scott, James R. Bagley Jan 2026

Nanomechanical Effects Of Microgravity On Murine Tendon Fibrils, Patrick Bialy, Andrew S. Ichimura, Kent A. Lorenz, Ryan T. Scott, James R. Bagley

International Journal of Exercise Science: Conference Proceedings

Microgravity, characterized by a weak gravitational pull, poses physiological risks to astronaut health and performance. While its impact on muscle and bone is well documented, effects on connective tissue, such as tendon, remain understudied. PURPOSE: This study aimed to 1) quantify the effects of 37 days of microgravity on the compressive nanomechanics of individual collagen fibrils and 2) compare these findings to existing literature and previously collected lab data. We hypothesized that spaceflight (SF) fibrils would exhibit a lower Young’s Modulus (YM) than ground controls (GC). METHODS: Female C57BL/6J mice were exposed to 37 days of spaceflight aboard the International …


Blood Product Transfusion And Coagulopathy In Children With Traumatic Brain Injury: A Narrative Review., Robert Marcel T. Huibonhoa, Niranjan Vijayakumar, Daniel Kelly, Oliver Karam, Madhuradhar Chegondi Jan 2026

Blood Product Transfusion And Coagulopathy In Children With Traumatic Brain Injury: A Narrative Review., Robert Marcel T. Huibonhoa, Niranjan Vijayakumar, Daniel Kelly, Oliver Karam, Madhuradhar Chegondi

Manuscripts, Articles, Book Chapters and Other Papers

Traumatic brain injury (TBI) is a leading cause of critical illness and mortality in children. Transfusion of blood products, a common intervention in the management of pediatric TBI, has important implications for related principles, including trauma-induced coagulopathy, cerebral perfusion, and cerebral oxygen delivery. Knowledge gaps persist due to the limited availability of pediatric-specific data regarding blood product transfusion in TBI. In particular, there is a lack of prospective studies defining appropriate specific laboratory thresholds and transfusion targets, as well as insufficient evidence to guide the weighing of potential benefits against transfusion-related risks in this population. Although blood product transfusion in …


Ethics Of Artificial Intelligence For Lawyers: Shall We Play A Game? The Rise Of Artificial Intelligence And The First Cases, Cliff Mckinney Jan 2026

Ethics Of Artificial Intelligence For Lawyers: Shall We Play A Game? The Rise Of Artificial Intelligence And The First Cases, Cliff Mckinney

Arkansas Law Notes

In the 1983 movie WarGames, a young computer hacker accidentally accesses a United States military supercomputer programmed to run nuclear war simulations. Four decades after WarGames, lawyers are now facing similar challenges of learning to use and communicate with artificial intelligence––hopefully without destroying the world. Artificial intelligence tools, such as ChatGPT, Claude, and Gemini, are quickly being incorporated into legal practice. These systems can draft documents, perform analysis, and support other legal tasks. While lawyers adjust to these new technologies, courts and regulatory authorities are actively developing appropriate frameworks to guide and supervise the use of these tools within the …


Only One Percent Of Important Shark And Ray Areas In The Western Indian Ocean Are Fully Protected From Fishing Pressure, Jesse E.M. Cochran, Ryan Charles, Andrew J. Temple, Peter M. Kyne, Emiliano García-Rodríguez, Adriana Gonzalez-Pestana, Amanda Batlle-Morera, Théophile L. Mouton, Asia O. Armstrong, Christoph A. Rohner, Darren J. Coker, Royale S. Hardenstine, Alexander Kattan, Ashlie J. Mcivor, Viktor Nunes Peinemann, Kaitlyn A. O'Toole, Lea Palm, Eloise B. Richardson, David A. Ebert, For Full Author List, See Comments Below Jan 2026

Only One Percent Of Important Shark And Ray Areas In The Western Indian Ocean Are Fully Protected From Fishing Pressure, Jesse E.M. Cochran, Ryan Charles, Andrew J. Temple, Peter M. Kyne, Emiliano García-Rodríguez, Adriana Gonzalez-Pestana, Amanda Batlle-Morera, Théophile L. Mouton, Asia O. Armstrong, Christoph A. Rohner, Darren J. Coker, Royale S. Hardenstine, Alexander Kattan, Ashlie J. Mcivor, Viktor Nunes Peinemann, Kaitlyn A. O'Toole, Lea Palm, Eloise B. Richardson, David A. Ebert, For Full Author List, See Comments Below

Faculty Research, Scholarly, and Creative Activity

The Western Indian Ocean (WIO) is known for its high diversity of chondrichthyans (sharks, rays, and chimaeras). However, intense fishing pressure has led to severe population declines and local extinctions of several species. The Important Shark and Ray Area (ISRA) process is a collaborative, evidence-based approach used to identify critical habitat for chondrichthyans. We analysed ISRAs across the WIO to quantify the diversity of research methods used to identify them, evaluate spatial overlap with designated marine protected areas (MPAs), model the influence of several species- and jurisdiction-specific variables on ISRA delineation, and explore the importance of incorporating unpublished data into …


Interactive Effects Of Hyposalinity And Nitrate Loading On Growth, Physiology, And Nitrogen Status Of The Seagrass, Halodule Wrightii, Joseph L. Kowalski, Hudson R. Deyoe, Kirk Cammarata, Kristina P. Vatcheva Jan 2026

Interactive Effects Of Hyposalinity And Nitrate Loading On Growth, Physiology, And Nitrogen Status Of The Seagrass, Halodule Wrightii, Joseph L. Kowalski, Hudson R. Deyoe, Kirk Cammarata, Kristina P. Vatcheva

School of Earth, Environmental, & Marine Sciences Faculty Publications

The study goal was to examine the interactive physiological effects of two freshwater inflow stressors, nitrate pulses coupled with salinity decrease, on the seagrass Halodule wrightii. A microcosm experiment was designed to approximate an observed freshwater inflow event. Over a 13-day period plants were subjected to three sequential salinity drops (S35→ S23→ S15→ S5) with nitrate-nitrogen added simultaneously at 0, 30 or 60 µM. For comparisons, the Control was no salinity change and no nitrate added denoted by S35/No N. Measurements of H. wrightii shoot production, photosynthesis, respiration, quantum efficiency, %N, C:N ratios and δ15N …


Perception As Beholding: Theological Possibility And Moral Implication Of Merleau-Ponty's Notion Of Embodied Subject, Erickson L. Totanes Jan 2026

Perception As Beholding: Theological Possibility And Moral Implication Of Merleau-Ponty's Notion Of Embodied Subject, Erickson L. Totanes

Budhi: A Journal of Ideas and Culture

In this article, I argue that Merleau -Ponty’s concept of perception reveals a way of seeing where the subject is involved with the object in a dynamic, reversible, and expanding relationship. This notion challenges the traditional and Cartesian subject -object dichotomy by emphasizing the embodied and lived experience of perception which elicits a process, a way of looking, anticipating, and reflexively, a way of being itself. By aligning seeing with beholding, I attempt to show how as simple an act as seein g evokes a manner of being related to an object, other people, and the world. The emergence of …


Analysis Of Students' Creativity Through Waste Recycling Activities Into Artistic Crafts In Grade V Of Sd Inpres Boyantongo, Yulvin Agnesia Metiro, Sarintan N Kaharu, Nuraini Nuraini, Yun Ratna Lagandesa, Kadek Hariana Jan 2026

Analysis Of Students' Creativity Through Waste Recycling Activities Into Artistic Crafts In Grade V Of Sd Inpres Boyantongo, Yulvin Agnesia Metiro, Sarintan N Kaharu, Nuraini Nuraini, Yun Ratna Lagandesa, Kadek Hariana

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

This study aims to analyze students’ creativity through waste recycling activities into art crafts in Grade V at SD Inpres Boyantongo. This research employs a descriptive method with a qualitative approach. The research subjects consisted of 18 students, including 11 boys and 7 girls in the 2024/2025 academic year. Data were collected through observation, interviews, questionnaires, and documentation, focusing on the four aspects of creativity proposed by Munandar: innovation, imagination, originality, and elaboration. The results show that students’ creativity is categorized as good, although not yet fully optimal. In terms of innovation, students tended to use easily obtained materials and …


Subcutaneous Insulin Use In Diabetic Ketoacidosis, Patrick Mcgrath Jan 2026

Subcutaneous Insulin Use In Diabetic Ketoacidosis, Patrick Mcgrath

Lynchburg Journal of Medical Science

The reviewed literature focuses on the clinical application of subcutaneous (SQ) insulin, particularly rapid-acting insulin analogs (RAIAs), in treating selected patients with mild to moderate diabetic ketoacidosis (DKA). The use of SQ insulin offers a viable alternative to traditional intravenous (IV) insulin infusions, enabling DKA management outside intensive care unit (ICU) settings and reducing healthcare resource utilization. Current DKA management protocols emphasize comprehensive fluid resuscitation and correction of electrolyte imbalances, with IV regular insulin administered at 0.1 units/kg/hour. This review synthesizes findings from multicenter cohort studies, meta-analyses, and randomized controlled trials (RCTs) available via PubMed, focusing on adult patients diagnosed …


Forever Un-Wild: How The Forever Wild Clause “Locks Up” New York’S Closed Correctional Facilities, William Carswell Jan 2026

Forever Un-Wild: How The Forever Wild Clause “Locks Up” New York’S Closed Correctional Facilities, William Carswell

Pace Environmental Law Review

Article XIV of the New York State Constitution, better known as the “Forever Wild Clause,” enshrines a conservationist ideal into law. The crux of article XIV prohibits the leasing, selling, or exchanging of state-owned land within New York’s Forest Preserve to private entities. Since its inception, this mandate has dictated the State’s approach to management of its Forest Preserve. Whenever New York decides to excise a piece of its Forest Preserve, the cumbersome yet necessary constitutional amendment process is triggered. Renewed attention to this legal requirement is peaking. Since 2009, five former Department of Corrections and Community Supervision sites located …


Surf And Turf: How Litigation Against Concentrated Animal Feeding Operations Can Inform Regulation Of The Aquaculture Industry, Amanda Kapitula Jan 2026

Surf And Turf: How Litigation Against Concentrated Animal Feeding Operations Can Inform Regulation Of The Aquaculture Industry, Amanda Kapitula

Pace Environmental Law Review

Industrial agriculture dominates the U.S. agricultural industry. On land, animals are stuffed into factory-like facilities, called concentrated animal feeding operations (“CAFOs”), where they are raised to maximize the output of food products. In the process, they produce vast amounts of waste, contaminating surrounding air and water resources. Increasingly, factory farms are making their way into the water as the fishing industry shifts from wild-catch systems to aquaculture operations, or the raising of fish for consumption. While aquaculture has the potential to be a more sustainable option than both wild-catch and animal agriculture, concentrated aquatic animal production facilities (“CAAPFs”) also have …


Reclaiming My Story: A Freirean Framework For Surviving Trauma And Transforming Recovery Into Liberation, Carl Bryan Jan 2026

Reclaiming My Story: A Freirean Framework For Surviving Trauma And Transforming Recovery Into Liberation, Carl Bryan

The Interactive Journal of Global Leadership and Learning

This white paper explores trauma recovery through the lens of Paulo Freire’s Pedagogy of the Oppressed (1970/2018), framing healing as an act of critical consciousness and liberation rather than passive survival. Using the author’s lived experience of stalking, manipulation, and emotional abuse as a case study, it reimagines recovery not as a return to normalcy but as a dialectical process of reclaiming narrative agency, reconstructing identity, and transforming pain into purpose. Drawing upon Freirean concepts of conscientização (critical consciousness), dialogue, and praxis, the paper outlines a model for survivors to move from internalized oppression toward empowerment and social transformation.


26 Conference - Innovative Materials & Methods For Additive Manufacturing Iii (Im2am), Brett Compton, Eric Eastwood, Nikhil Gupta, Daniel Schmidt, Joamin Gonzalez-Gutierrez, Pedro Cortes Jan 2026

26 Conference - Innovative Materials & Methods For Additive Manufacturing Iii (Im2am), Brett Compton, Eric Eastwood, Nikhil Gupta, Daniel Schmidt, Joamin Gonzalez-Gutierrez, Pedro Cortes

Innovative Materials & Methods for Additive Manufacturing III (IM²AM)

No abstract provided.


The Pure Yang Mills Field V2, James Glimm Jan 2026

The Pure Yang Mills Field V2, James Glimm

Department of Applied Mathematics & Statistics Faculty Publications

We construct a pure Yang-Mills field based on a non-Abelian simple gauge group.

Axioms and the mass gap are satisfied.


Broad Laboratory Testing Does Not Show Utility For Telogen Effluvium: A Retrospective Analysis Of 22-Million Laboratory Results Using Trinetx, Zachary J.K. Neubauer, Shari R. Lipner Jan 2026

Broad Laboratory Testing Does Not Show Utility For Telogen Effluvium: A Retrospective Analysis Of 22-Million Laboratory Results Using Trinetx, Zachary J.K. Neubauer, Shari R. Lipner

Student Papers, Posters & Projects

No abstract provided.


Real-World Data Investigating The Frequency Of Flash Glucose Monitoring And Glycaemic Metrics In Omani Diabetes Patients: A Preliminary Retrospective Cross-Sectional Study, Ammar Al-Mamari, Sumaia Al Gharabi, Merah Al Busaidy, Abdulla Al Futaisi Jan 2026

Real-World Data Investigating The Frequency Of Flash Glucose Monitoring And Glycaemic Metrics In Omani Diabetes Patients: A Preliminary Retrospective Cross-Sectional Study, Ammar Al-Mamari, Sumaia Al Gharabi, Merah Al Busaidy, Abdulla Al Futaisi

Sultan Qaboos University Medical Journal

Objectives: This study aimed to evaluate real-world glycaemic outcomes associated with flash glucose monitoring (FGM) use in patients with diabetes at Sultan Qaboos University Hospital, Muscat, Oman. Methods: This retrospective cross-sectional study was conducted among diabetic patients using flash glucose monitoring between January 2022 and August 2023. Patients were grouped by scanning frequency, time-in-range (TIR) and estimated A1c (eA1c). Associations between scanning frequency and glycaemic metrics were analysed. Results: A total of 436 patients were included in this study. Patients with higher scanning frequency (≥12 scans/day, median = 17) achieved greater TIR (52.4% versus 34.8%), lower time-above-range (41.8% versus 57.0%), …


Financial Ratios And Stock Volatility: Empirical Evidence From The Banking Sector, Rahma Tri Benita Jan 2026

Financial Ratios And Stock Volatility: Empirical Evidence From The Banking Sector, Rahma Tri Benita

Journal of Accounting Auditing and Business

Banking stock price volatility is closely related to company performance and fundamental indicators. This study analyzes the short-term and long-term relationships between financial ratios and stock price volatility in the banking sector. Based on the results of the long-term correlation, the Price to Earnings Ratio (P/E) and Dividend Yield (DY) variables are proven to be dominant factors influencing volatility because they are directly related to stock price movements. In the short-term correlation between state-owned banks, there is an inverse relationship between Price to Book and ROE, and Debt to Equity has a significant negative effect on Return on Assets and …


Identification Of Cadm1 As An Immunotherapeutic Target And Evaluation Of A Novel Cadm1-Targeting Antibody-Drug Conjugate In Preclinical Osteosarcoma Models, Yifei Wang, Zhongting Zhang, Caterina Longo, Wendong Zhang, Qi Wang, Amer Najjar, Xiangjun Tian, Rossana N Lazcano Segura, Michael E Roth, Jonathan Gill, Douglas J Harrison, Zhaohui Xu, Yanhua Yi, Xin Zhou, Sylvester Jusu, Timothy M Stearns, Steven B Neuhauser, Carol J Bult, Jing Wang, Alexander J Lazar, Richard Gorlick Jan 2026

Identification Of Cadm1 As An Immunotherapeutic Target And Evaluation Of A Novel Cadm1-Targeting Antibody-Drug Conjugate In Preclinical Osteosarcoma Models, Yifei Wang, Zhongting Zhang, Caterina Longo, Wendong Zhang, Qi Wang, Amer Najjar, Xiangjun Tian, Rossana N Lazcano Segura, Michael E Roth, Jonathan Gill, Douglas J Harrison, Zhaohui Xu, Yanhua Yi, Xin Zhou, Sylvester Jusu, Timothy M Stearns, Steven B Neuhauser, Carol J Bult, Jing Wang, Alexander J Lazar, Richard Gorlick

Faculty, Staff and Student Publications

Due to the paucity of validated cell surface osteosarcoma-specific targets, patients with this condition have long been excluded from the benefits of antibody-drug conjugate (ADC) therapy observed in patients with several solid and hematologic malignancies. Our comprehensive surfaceome profiling approach previously identified osteosarcoma-specific cell-surface antigens that are highly expressed in osteosarcomas but minimally expressed in normal tissues. As a result, one such antigen, CADM1, was selected for the generation of an ADC. We tested a CADM1-targeting ADC with a tesirine payload (SG3249) in vitro in osteosarcoma, rhabdomyosarcoma, and neuroblastoma patient-derived xenograft cell lines. In vivo, we tested six CADM1-expressing osteosarcoma …


Unravelling Impact Of Comorbidities On Mortality Risks In Ckd Patients During The Covid-19 Pandemic: An Explainable Ai-Driven Study, Zeinab Abdollahi, Lin Huo, Donald Fraser, Shang-Ming Zhou Jan 2026

Unravelling Impact Of Comorbidities On Mortality Risks In Ckd Patients During The Covid-19 Pandemic: An Explainable Ai-Driven Study, Zeinab Abdollahi, Lin Huo, Donald Fraser, Shang-Ming Zhou

School of Nursing and Midwifery

ObjectivesThe chronic kidney disease (CKD) patients were at high risk for severe clinical complications during the COVID-19 pandemic. Our objectives were to evaluate comorbidity prevalence; predict mortality risks for CKD patients during the pandemic; assess how various health factors interact to influence mortality; and provide insights for targeted prevention strategies.MethodWe analysed data from 186,396 CKD patients in Mexico during the entire pandemic (Jan 2020- May 2023). Explainable artificial intelligence (XAI) methods with extreme gradient boosting (XGBoost) models and Shapley Additive Explanations (SHAP) were developed to predict mortality for CKD patients with model interpretations. Different metrics were used to comprehensively evaluate …


An Optimized Hybrid Xgboost-Lstm-Gru Model For Energy Consumption Forecasting In Smart Homes Using Weather Data, Marwah J. Salman, Eman M. El-Gendy, Amira Y. Haikal, Mahmoud M. Saafan Jan 2026

An Optimized Hybrid Xgboost-Lstm-Gru Model For Energy Consumption Forecasting In Smart Homes Using Weather Data, Marwah J. Salman, Eman M. El-Gendy, Amira Y. Haikal, Mahmoud M. Saafan

Mansoura Engineering Journal

Energy consumption is increasing every day due to the proliferation of smart homes and smart household appliances, which deplete existing energy resources. Therefore, efficient energy management by accurately predicting energy consumption is critical. In this paper, a hybrid prediction model is proposed to forecast energy consumption in smart homes using weather data. The proposed system follows five steps: data acquisition, data preprocessing, feature selection, prediction, and hyperparameter optimization. In the data acquisition step, all attributes except the weather attributes are removed. The min-max algorithm is then applied to normalize the dataset to a specific scale, preventing the prediction model from …


Administrative Appeal Decision - Robertson, Thomas (2025-10-31) Jan 2026

Administrative Appeal Decision - Robertson, Thomas (2025-10-31)

Parole Administrative Appeal Decisions

No abstract provided.


Administrative Appeal Decision - Jackson, Calvin (2025-10-01) Jan 2026

Administrative Appeal Decision - Jackson, Calvin (2025-10-01)

Parole Administrative Appeal Decisions

No abstract provided.


Decision In Art. 78 Proceeding - Dones, Juan (2025-10-24) Jan 2026

Decision In Art. 78 Proceeding - Dones, Juan (2025-10-24)

Decisions in Art. 78 Proceedings

No abstract provided.