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Conditional Execution Of Compiler Passes Based On Per-Script Feature Detection, Rishipal Singh Bhatia, Laura Harker Jan 2026

Conditional Execution Of Compiler Passes Based On Per-Script Feature Detection, Rishipal Singh Bhatia, Laura Harker

Defensive Publications Series

Source-to-source compilers may perform inefficiently by executing transpilation passes on scripts that do not contain the specific language features a pass is designed to transform, potentially leading to redundant processing. A compiler can analyze a script to generate a per-script feature map, for example, by identifying language features in its abstract syntax tree (AST). Before executing a transpilation pass, the compiler can check this map and may bypass the pass for that script if the specific feature targeted by the pass is not present. This feature map can also be dynamically updated throughout the compilation process as other passes transform …


“The Monster That Ate Jurisprudence”: The Misfire Of Civil Rico In Third-Party Payor Recovery, Jillian Rae Bloom Jan 2026

“The Monster That Ate Jurisprudence”: The Misfire Of Civil Rico In Third-Party Payor Recovery, Jillian Rae Bloom

University of Miami Business Law Review

A law created to dismantle organized crime is now being misused to target pharmaceutical companies. The Racketeer Influenced and Corrupt Organizations Act (RICO), originally intended to combat criminal enterprises, has since expanded far beyond its intended purpose. Third-party payors (TTPs), such as health insurers, have increasingly relied on RICO to sue pharmaceutical companies for deceptive marketing practices that allegedly cause significant financial harm. While it is important to hold pharmaceutical companies accountable for their fraudulent conduct, applying RICO in these cases represents a troublesome overreach. The link between the alleged fraud and TPPs alleged harm is too attenuated to meet …


Tracing The Truth: Strengthening U.S. Food Traceability With Lessons From The Eur. Union, Carolina Gomez Jan 2026

Tracing The Truth: Strengthening U.S. Food Traceability With Lessons From The Eur. Union, Carolina Gomez

University of Miami Business Law Review

The United States (U.S.) has made significant progress in improving food traceability, with the FDA’s Final Food Traceability Rule set to take effect in 2026. This long-overdue regulation aims to improve outbreak response and better protect public health. However, major gaps in the U.S. traceability system remain, leaving consumers exposed to preventable foodborne illness outbreaks. Legislative challenges, including H.R. Bill 7563 and provisions in the Fiscal Year 2025 Agriculture Appropriations bill, threaten to delay or weaken these necessary reforms. Compounding these challenges, on August 7, 2025, the FDA proposed extending the compliance deadline for the rule by 30 months, to …


Examining The Science Of Reading Focusing On Phonemic Awareness And Multicultural Literature To Enhance Reading Achievement Among African American Students, Danielle L. Gantt Jan 2026

Examining The Science Of Reading Focusing On Phonemic Awareness And Multicultural Literature To Enhance Reading Achievement Among African American Students, Danielle L. Gantt

Theses and Dissertations

This mixed-methods action research study examined how implementing the CKLA, Core Knowledge Language Arts, curriculum, founded in the science of reading, enhanced the reading achievement among first-grade African American students. The purpose of the study was to explore how phonics instruction, specifically phonemic awareness, and multicultural literature would improve literacy. The study was guided by Ivankova’s six-phased mixed methods model integrating quantitative and qualitative data. The quantitative data collected included the DIBELS, Dynamic Indicators of Basic Early Literacy Skills, benchmark and progress monitoring assessments. The qualitative data included student work samples, multicultural literature lessons, and open-ended student responses. The quantitative …


Intelligent Skies: Deep Learning Architectures For Scalable Aviation Safety Systems, Amine Khelifi Jan 2026

Intelligent Skies: Deep Learning Architectures For Scalable Aviation Safety Systems, Amine Khelifi

Theses and Dissertations

The growing complexity of aviation operations, particularly in rotorcraft and vertical flight necessitates the development of intelligent, automated systems to enhance safety and situational awareness. This thesis investigates the application of artificial intelligence (AI), with a focus on deep learning (DL), to address critical safety challenges in aviation. Four core use cases are examined: helicopter cockpit flight data monitoring, runway detection, helipad segmentation, and obstacle localization around rotorcraft landing zones. Each application targets a specific gap in current aviation infrastructure, with an emphasis on operational needs identified by the Federal Aviation Administration (FAA). Leveraging a range of DL architectures, including …


N-Acetylcysteine Is Associated With Changes In Functional Connectivity In Patients With Parkinson's Disease, Daniel A. Monti, George Zabrecky, Daniel Kremens, Tsao-Wei Liang, Nancy A. Wintering, Faezeh Vedaei, Emily Navarreto, Monisha Gupta, Alicia Steinmetz, Anthony J. Bazzan, Feroze Mohamed, Andrew B. Newberg Jan 2026

N-Acetylcysteine Is Associated With Changes In Functional Connectivity In Patients With Parkinson's Disease, Daniel A. Monti, George Zabrecky, Daniel Kremens, Tsao-Wei Liang, Nancy A. Wintering, Faezeh Vedaei, Emily Navarreto, Monisha Gupta, Alicia Steinmetz, Anthony J. Bazzan, Feroze Mohamed, Andrew B. Newberg

Marcus Institute of Integrative Health Faculty Papers

INTRODUCTION: This study assessed the changes in functional connectivity from resting functional magnetic resonance imaging (fMRI) in patients with Parkinson's disease (PD) given N-Acetylcysteine (NAC), the prodrug to L-cysteine and a precursor to the natural biological antioxidant glutathione (GSH). The aim of this study was to determine whether NAC is associated with changes in functional connectivity, particularly in the basal ganglia, and improvements in Parkinson's symptoms.

METHODS: Forty-four patients with PD were randomized to either weekly intravenous infusions of NAC (50 mg/kg) plus oral doses (500 mg twice per day) for six months plus standard of care, or standard of …


Integrated Proteomics To Understand The Role Of Neuritin-1 (Nrn1) As A Molecular Mediator Of Synaptic Resilience In Alzheimer’S Disease, Derian Pugh Jan 2026

Integrated Proteomics To Understand The Role Of Neuritin-1 (Nrn1) As A Molecular Mediator Of Synaptic Resilience In Alzheimer’S Disease, Derian Pugh

ETDs from 2020-2029

Alzheimer’s disease (AD) is the leading cause of dementia in adults over the age of 65, and currently affects approximately 6.9 million people in the United States. By 2060, the number of people age 65 and older with AD is projected to reach 13.8 million, barring the development of disease-altering therapies to prevent, slow or cure AD. Thus, there is a need for progress in the understanding of AD pathophysiology, as well as in the development of diagnostic and therapeutic interventions. Approximately one-third of individuals without dementia at the time of death are found to harbor high levels of amyloid-beta …


Cbct Evaluation Of Planned Vs. Achieved Expansion And Buccal Bone Thickness In Phase I Orthodontic Cases Treated With Clear Aligners, Jared Teeples Jan 2026

Cbct Evaluation Of Planned Vs. Achieved Expansion And Buccal Bone Thickness In Phase I Orthodontic Cases Treated With Clear Aligners, Jared Teeples

ETDs from 2020-2029

Introduction: Within orthodontics, CBCT technology has been used to analyze tooth movement with both fixed appliances and clear aligners. However, little research has evaluated alveolar bone remodeling outcomes in growing patients treated with clear aligner expansion. Methods: This study compared pre-treatment (T0) and post-treatment (T1) CBCTs of Phase I patients treated with clear aligners who had expansion planned in the Invisalign® ClinCheck. CBCTs were collected and analyzed, including 27 maxillary and 22 mandibular arches. The aims were (1) to compare planned vs. actual expansion and (2) to evaluate the arch width (AW) and alveolar bone changes before and after treatment. …


Exercise Testing And Training For Individuals With Cystic Fibrosis, Najlaa Zayed Alotaibi Jan 2026

Exercise Testing And Training For Individuals With Cystic Fibrosis, Najlaa Zayed Alotaibi

ETDs from 2020-2029

Cystic fibrosis (CF) is a progressive genetic disease that impacts multiple systems (e.g., respiratory system). Hence, routine cardiopulmonary exercise testing (CPET) is recommended to track the disease progression in people with CF. Besides the benefits of exercise testing, exercise training is also beneficial for long-term wellness. It is recommended that people with CF engage in at least 30–60 minutes of aerobic exercise 3 days a week. However, despite the significance of exercise testing and training for people with CF, CPET and exercise training are underutilized in international CF centers. According to the literature, the majority of international CF centers use …


Physical And Psychophysiological Responses To Self-Selected Music In Individuals With Parkinson's Disease, Sophia Porrill Jan 2026

Physical And Psychophysiological Responses To Self-Selected Music In Individuals With Parkinson's Disease, Sophia Porrill

ETDs from 2020-2029

Exercise is a cornerstone adjunct therapy for people with Parkinson’s Disease (PwP). However, exercise capacity is often impaired by non-motor processes including decreased motivation, arousal, and physical effort. Self-selected music (SSM) has been shown to improve motivation and arousal state in healthy individuals thereby leading to increases in exercise capacity. Whether these positive effects of SSM translate to PwP is unclear. The purpose of this study was to measure 1) the psychophysiological effects of SSM at rest, and 2) psychophysiological and physical responses during a 6-minute walk test (6MWT) in PwP. In a counterbalanced crossover manner, PwP (n=12) completed resting …


Analysis Of Activated Carbon Fiber (Acf) As Particulate Filtration And Volatile Organic Compound (Voc) Media For The Development Of A Dual-Air Purifying Facepiece Respirator, Brie Mcmahan Jan 2026

Analysis Of Activated Carbon Fiber (Acf) As Particulate Filtration And Volatile Organic Compound (Voc) Media For The Development Of A Dual-Air Purifying Facepiece Respirator, Brie Mcmahan

ETDs from 2020-2029

Exposure to particulate matter (PM) and volatile organic compounds (VOCs) in occupational or public settings poses adverse health outcomes such as respiratory, cardiovascular, reproductive, neurological, carcinogenic morbidity and mortality. Many occupational settings expose workers to PM and VOC concurrently, yet most commercially available respirators are designed to address either particulates or vapors alone. This includes air-purifying respirators (APRs), powered air-purifying respirators (PAPRs), and filtering facepiece respirators (FFRs) with nuisance-level vapor protection, often limited by bulk, discomfort, high pressure drop, and misuse. We identified a need for alternative dual-exposure media and a respiratory protection device that is lighter, and more comfortable …


Understanding Mobility Limitations And Public Transportation Accessibility For People With Disabilities, Jada Meria Stringer Jan 2026

Understanding Mobility Limitations And Public Transportation Accessibility For People With Disabilities, Jada Meria Stringer

ETDs from 2020-2029

Mobility for people with disabilities (PWDs) depends on both the availability of transportation and public services and the accessibility of these systems. The presence of public transportation systems does not ensure usability. Vehicles, infrastructure, and the built environment must be designed to accommodate diverse physical, sensory, cognitive, and other needs. PWDs must also be able to navigate public buildings and surrounding spaces safely and comfortably. This thesis examines mobility limitations for PWDs in India and the United States, focusing on accessibility along the full mobility chain. A review of existing literature provides context on accessibility policies, design standards, and the …


Biomineralization Of Low Temperature Plasma(Ltp) Modified Polymeric Biomaterials And Scaffolds, John Patrick Bradford Jan 2026

Biomineralization Of Low Temperature Plasma(Ltp) Modified Polymeric Biomaterials And Scaffolds, John Patrick Bradford

ETDs from 2020-2029

Bio-integration, specifically osseo-integration of bone implants and scaffolds, are vital for the success of implants and bone tissue engineering (BTE). Calcification can be defined as the deposition of calcium compounds as either calcium phosphate(CaP) minerals consisting of hydroxyapatite(HAP) or CaP salts. The significance of the variety of phases of CaP is that mature bone matrix is composed of 65% CaP mineral. Many investigators have attempted to model the natural matrix by producing materials containing calcium phosphate in both amorphous CaP or in the more crystalline HAP form, with biomaterials (both synthetic and biological). Biomimetic CaP formation is a sign of …


Development Of Human Trophoblast Cell Surface Antigen-2 (Trop-2) Specific Radiopharmaceutical Tracers, Arnav Vipulkumar Patel Jan 2026

Development Of Human Trophoblast Cell Surface Antigen-2 (Trop-2) Specific Radiopharmaceutical Tracers, Arnav Vipulkumar Patel

ETDs from 2020-2029

Trophoblast cell surface antigen 2 (Trop2) is closely related to the development and progression of triple-negative breast cancers (TNBC) and is also being investigated as a pan-cancer biomarker. Trop-2 tumorigenesis is mediated by the calcium ion signaling pathways. By accurately predicting and targeting Trop-2 for immunotherapy, precision therapy is crucial. Trop-2 is overexpressed in tumor tissues compared to normal tissues, which makes it a promising molecular target for cancer-targeted therapy. This thesis reports the development and preclinical evaluation of two novel Trop-2-specific radiopharmaceutical tracers derived from the clinically approved antibody-drug conjugate Sacituzumab Govitecan (SG): a full antibody drug conjugate-based tracer …


Quantum Technologies, Part One: Focusing A Bit Upon Realities, James Giordano Jan 2026

Quantum Technologies, Part One: Focusing A Bit Upon Realities, James Giordano

Strategic Insights

This commentary examines the current realities of quantum technologies and their implications for national security and defense. While quantum systems are often described as revolutionary, their practical military impact remains uneven and frequently overstated. This analysis reviews three key domains—quantum computing, sensing, and communications, and explains where these technologies currently outperform classical systems and where significant technical limitations remain. In particular, quantum computing is still in a “noisy, intermediate-scale” stage, meaning most applications remain experimental and dependent on advances in error correction, algorithms, and hardware. Understanding both the promise and limitations of quantum technologies is essential for shaping realistic defense …


Spherex: Aromatics, Aliphatics, And Pah Size Across The Iris Nebula, C. Boersma, A. Maragkoudakis, L. J. Allamandola, J. D. Bregman, P. Temi, Vincent J. Esposito, R. C. Fortenberry Jan 2026

Spherex: Aromatics, Aliphatics, And Pah Size Across The Iris Nebula, C. Boersma, A. Maragkoudakis, L. J. Allamandola, J. D. Bregman, P. Temi, Vincent J. Esposito, R. C. Fortenberry

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Observations by the Spectro-Photometer for the History of the Universe, Epoch of Reionization, and Ices Explorer (SPHEREx) are combined with counterpart Spitzer spectral map data to study the aromatic, aliphatic, and polycyclic aromatic hydrocarbon (PAH) size evolution across the northwest photodissociation region (PDR) of the Iris Nebula (NGC 7023). The 3.3–3.4 μm complex (I3.3) and 11.2 μm (I11.2) PAH band strength are determined through direct integration. In addition, the former is decomposed into a 3.3 (I3.3) and 3.4 μm (I3.4) subfeature by fitting SPHEREx bandpass-integrated photometry using a modeled, highly sampled, multicomponent …


Derivative Attorney-Client Privilege In Organizations, Douglas R. Richmond Jan 2026

Derivative Attorney-Client Privilege In Organizations, Douglas R. Richmond

University of Miami Business Law Review

A lawyer and client must be able to communicate about the client’s legal affairs in confidence for the lawyer to be able to meaningfully advise the client, hence courts’ recognition of the attorney-client privilege. Fundamentally, the very term “attorney-client privilege” seemingly requires a lawyer’s participation in a communication for the privilege to attach. But, in fact, lawyers need not always participate in client communications for the attorney-client privilege to shield the communications from discovery. Clients or their employees’ confidential conversations among themselves with respect to legal matters sometimes deserve privilege protection. This derivative application of the privilege can be crucial …


Effects Of Leucine Supplementation On Athletic Performance, Central Fatigue, And Serum Metabolism In Endurance Athletes: A Randomized Controlled Trial And Targeted Metabolomics Study, Tieying Li, Wei Xu, Jun Chen, Zhaobo Kan, Xuemei Sui, Zhiguang Zhao, Qirong Wang Jan 2026

Effects Of Leucine Supplementation On Athletic Performance, Central Fatigue, And Serum Metabolism In Endurance Athletes: A Randomized Controlled Trial And Targeted Metabolomics Study, Tieying Li, Wei Xu, Jun Chen, Zhaobo Kan, Xuemei Sui, Zhiguang Zhao, Qirong Wang

Faculty Publications

Objectives: We aimed to investigate the effects of 6 weeks of leucine supplementation on athletic performance, central fatigue, and serum metabolome in endurance athletes, and to provide valuable insights into nutritional strategies for endurance athletes. Methods: Twenty cross-country skiers were recruited and randomized into 2 groups: the placebo (PLA) group and the leucine (LEU) group. Subjects were given leucine (8.5 g) + sucrose (14 g) or only sucrose (14 g) supplements twice each day from Monday to Saturday for 6 weeks. Test parameters include body composition, aerobic capacity, isokinetic muscle strength, blood biochemistry, and targeted metabolomics. Results: After intervention, compared …


Staff Education To Increase Knowledge And Awareness Of Cultural Sensitivity Among Providers, Stephanie Chiamaka Anyanwu Jan 2026

Staff Education To Increase Knowledge And Awareness Of Cultural Sensitivity Among Providers, Stephanie Chiamaka Anyanwu

Walden Dissertations and Doctoral Studies

This Doctor of Nursing Practice (DNP) project aimed to enhance cultural sensitivity among healthcare providers through an educational intervention in a local organization. With the U.S. foreign-born population exceeding 47 million, the need for culturally competent care has become paramount. The study involved nine participants who underwent a pretest and posttest assessment to evaluate their knowledge and awareness of cultural sensitivity. Results indicated a significant increase in knowledge, with pretest and posttest scores improving from a mean of 4.33 to 8.56 (p < 0.01). Awareness in key areas such as patient-provider relationships, cultural beliefs, and language barriers also showed marked improvement. These findings further support the necessity of ongoing cultural sensitivity training to enhance patient care and outcomes, highlighting the potential for broader application across healthcare institutions.


Minutes, Curriculum Committee Meeting, Tuesday, January 27, 2026, Curriculum Committee Jan 2026

Minutes, Curriculum Committee Meeting, Tuesday, January 27, 2026, Curriculum Committee

Curriculum Committee Minutes

No abstract provided.


Expanding Access To Live Donation Opportunities: Implementing Telehealth Solutions To Enhance The Living Donor Navigator Program, Alexis Carter Jan 2026

Expanding Access To Live Donation Opportunities: Implementing Telehealth Solutions To Enhance The Living Donor Navigator Program, Alexis Carter

ETDs from 2020-2029

Living donor kidney transplantation (LDKT) is the most effective treatment for patients with end-stage kidney disease; however, living donation rates have remained suboptimal over the past two decades. As a result, many interventions have been developed and tailored to increase living donation. The Living Donor Navigator (LDN) Program is one effort designed to help transplant candidates identify potential living donors and guide them through the donation process, using a combination of advocacy and systems training. The LDN Program is a lay-navigator-based intervention that equips participants with the knowledge, communication skills, and confidence needed to identify and engage potential living donors. …


Novel Retinal Biomarker Development In Early Alzheimer’S Disease, Swetha Ravichandran Jan 2026

Novel Retinal Biomarker Development In Early Alzheimer’S Disease, Swetha Ravichandran

ETDs from 2020-2029

Alzheimer’s disease is a progressive neurodegenerative disorder that causes damage to the neurons that are present in the brain. Progress in the management and treatment of AD is limited by lack of early diagnostics, which are critical to the development of effective therapies. It is therefore critical to develop non-invasive/cost efficient biomarkers to aid in early diagnosis and interventions to prevent or delay dementia onset. While Positron Emission Tomography (PET) and cerebrospinal fluid assessment have greatest utility, they are not routinely used because they are expensive and invasive, respectively. Retinal imaging offers a promising, low-cost, and non-invasive avenue for detecting …


Awareness And Knowledge Of Juvenile Idiopathic Arthritis Among Orthodontic And Oral And Maxillofacial Surgery Specialties In The United States., Kavita Nayar Jan 2026

Awareness And Knowledge Of Juvenile Idiopathic Arthritis Among Orthodontic And Oral And Maxillofacial Surgery Specialties In The United States., Kavita Nayar

ETDs from 2020-2029

Introduction: Juvenile Idiopathic Arthritis (JIA) is the most common chronic pediatric arthritis, frequently involving the temporomandibular joint (TMJ) and resulting in facial growth disturbances, functional impairment, and complex multidisciplinary treatment needs. Despite its clinical relevance, limited awareness and inconsistent management strategies exist among specialists who are involved in the care of these patients including orthodontists, oral and maxillofacial surgeons and rheumatologists. This study aimed to evaluate the understanding, knowledge and interdisciplinary management practices between board-certified orthodontists and oral and maxillofacial surgeons (OMSs) across the United States regarding JIA. Materials and Methods: A cross-sectional survey was distributed electronically via Qualtrics to …


Nutritional Care For Adults With Obesity Treated With Glp-1and Dual Gip/Glp-1 Receptor Agonists: A Review Of Evidence, Gaps, And Clinical Implications, Carolina Mcguane Jan 2026

Nutritional Care For Adults With Obesity Treated With Glp-1and Dual Gip/Glp-1 Receptor Agonists: A Review Of Evidence, Gaps, And Clinical Implications, Carolina Mcguane

Department of Nutrition Student Projects

Abstract

Background:

Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) and dual glucose-dependent insulinotropic polypeptide/glucagon-like peptide-1 receptor agonists (GIP/GLP-1 RAs) have revolutionized obesity management, producing unprecedented weight loss outcomes. Their widespread use has outpaced research on nutritional implications, adverse events, and evidence-based guidance for dietitians. Given the central role of nutrition practitioners in supporting adults with obesity, understanding the mechanisms, risks, and nutrition-related outcomes of GLP-1 therapies is critical.

Methods:

A comprehensive literature search was conducted utilizing PubMed, Embase, and Google Scholar to identify relevant peer-reviewed articles on the topic of glucagon-like peptide-1 receptor agonists (GLP-1 RAs) use and nutrition-related …


How To Finalize Pdfs To Correspond To American Disabilities Act (Ada) Tagging: The Basics, Kimberly Holling Jan 2026

How To Finalize Pdfs To Correspond To American Disabilities Act (Ada) Tagging: The Basics, Kimberly Holling

ScholarWorks Publications

This document is a basic step-by-step outline for tagging a PDF file in accordance with the American Disabilities Act (ADA).  ADA tagging allows a digital document to work well with screen readers in order to assist those with visual impairments to more fully engage with a document's content.  This is not a comprehensive guide, as it will not cover forms or complex tables.  This specific workflow shows how to use Adobe Acrobat Pro to work with, finalize, and verify accessibility in PDFs created from simple Word documents.  Such documents should already use Word heading and list features and very simple …


Exploring The Relationship Among Nurse-Specific Factors And Triage Accuracy In The Emergency Setting, Krisada Suamchaiyaphum Jan 2026

Exploring The Relationship Among Nurse-Specific Factors And Triage Accuracy In The Emergency Setting, Krisada Suamchaiyaphum

ETDs from 2020-2029

Triage is a critical function of emergency nursing practice, directly influencing patient safety, flow, and outcomes in the emergency department (ED). Despite widespread use of standardized triage training and resources, triage accuracy among ED nurses remains suboptimal. The purpose of this three-manuscript dissertation was to examine factors associated with triage accuracy in the ED setting. Manuscript One was an integrative literature review of 14 studies published between 2011 and 2021, with reported triage accuracy rates ranging from 59.3% to 82%. Primary factors associated with triage accuracy were: nurse-specific, patient, and work environment factors. Manuscript Two reported a retrospective study of …


Psychosocial Outcomes In Adults With Cleft Lip And Palate: Exploring The Relationship Between Cleft Severity, Mental Health, And Treatment Satisfaction, Haley Hannabass Jan 2026

Psychosocial Outcomes In Adults With Cleft Lip And Palate: Exploring The Relationship Between Cleft Severity, Mental Health, And Treatment Satisfaction, Haley Hannabass

ETDs from 2020-2029

Introduction:This study aimed to examine psychosocial outcomes in adults with cleft lip and palate (CL/P), focusing on how cleft severity (unilateral versus bilateral) influences depression, anxiety, social functioning, oral health–related quality of life, and satisfaction with treatment outcomes. Individuals born with clefts often continue to face psychosocial challenges even after surgical repair, and limited research has compared how these outcomes differ by cleft type in adulthood. Materials and Methods:A cross-sectional design was used, including 24 adults aged 18 years and older who had undergone cleft repair and were finished or in active orthodontic treatment at UAB. Participants completed an online …


Handling Missing Data In Copd Research, Chia-Ying Chiu Jan 2026

Handling Missing Data In Copd Research, Chia-Ying Chiu

ETDs from 2020-2029

Chronic Obstructive Pulmonary Disease (COPD) remains a major global health concern and one of the leading causes of death in the United States, affecting approximately 4.6% of adults and reaching a prevalence of 9.4% in Alabama according to 2024 National Health Interview Survey. The disease imposes a substantial burden on quality of life and healthcare costs and contributes to increased disability-adjusted life years and years of life lost, as highlighted by the 2022 Lancet Commission report. Despite its im-pact, COPD is frequently diagnosed only after irreversible lung damage has occurred, largely due to under-recognized symptoms and limited diagnostic tools. Early …


Development Of Salinomycin Analogs As Potential Anti-Cancer Agents, Pavan Goud Juluri Jan 2026

Development Of Salinomycin Analogs As Potential Anti-Cancer Agents, Pavan Goud Juluri

Theses and Dissertations

Salinomycin, a poly-ionophore antibiotic originally isolated from Streptomyces albus, exhibits antimicrobial activity against Gram-positive bacteria. Over the years Salinomycin has been studied in the effects it has on cancer, specifically cancer stem cells. Poly(ADP-ribose) polymerase (PARP) is an enzyme involved in DNA repair. Inhibiting PARP has been explored as a strategy in cancer treatment, particularly in cancers with defective DNA repair mechanisms, such as those with BRCA mutations. The benzo-thiazoles, and -imidazoles are identified as inhibitor scaffolds, which compete with nicotinamide in the binding pocket of human poly- and mono-ADP-ribosylating enzymes. Benzothiazole, and benzimidazole based compounds particularly with modification at …


Through The Ages: Reflecting On 250 Years Of Ai Technology, Ethan Brue Jan 2026

Through The Ages: Reflecting On 250 Years Of Ai Technology, Ethan Brue

Faculty Work Comprehensive List

"The only thing historians know for certain is that humans have been proven quite inept at being certain, particularly when it involves the future."

Posting about the longterm influence of artificial intelligence from In All Things, an online hub that offers insight into maintaining and faithful and orthodox Reformed Christian worldview while fearlessly engaging in every aspect of contemporary life – until all is made new.

Through the Ages