Digital Commons Network^™

Preliminary Evidence Of Blood Dna Methylation Changes In Pregnant Women Adhering To A Mediterranean Diet, Grace Tavelli, Nikki Schultz, Joanna Brisbane, Nina Kresoje, Samantha Lodge, Jeremy K. Nicholson, Nicola J. Armstrong, Desiree Silva, Nina D’Vaz, David Martino

Research outputs 2022 to 2026

Background/Objectives: Consumption of a Mediterranean diet (MD) has been associated with reduced incidence of non-communicable diseases and reduced overall mortality, with epigenomic effects representing plausible mediators. The aim of this pilot study was to explore potential epigenetic associations between DNA methylation markers in blood and adherence to an MD in pregnancy. Methods: Fifty-two pregnant women with high or low adherence to an MD throughout pregnancy, who participated in the BioMood ORIGINS study, were selected using an extremes-of-exposure design. DNA methylation (DNAm) profiles from whole blood were generated using the TWIST human methylome panel. We conducted both genome-wide and candidate gene-based …

Towards Automated Assessment Of Students Self-Explanations In Code Comprehension, Jeevan Chapagain

Electronic Theses and Dissertations Archive

The field of computer science faces a significant challenge in meeting the growing demand for skilled graduates, despite increasing interest in CS education. A persistent gap between supply and demand is partly attributed to high attrition rates of 30-40% (or higher) in introductory CS courses (CS1 and CS2). While various interventions have been proposed, the scalable assessment of students’ understanding of programming concepts remains a critical challenge, particularly in the context of code comprehension exercises. This dissertation addresses the challenge of automated assessment in code comprehension by developing and evaluating novel approaches for analyzing students’ self-explanations of program code. We …

Predictive Validity Of The Obsessive-Compulsive Inventory-4 And Florida Obsessive-Compulsive Inventory-Ii Severity Scale, Eric A. Storch, Ryan J. Mccarty, Maya Zehavi, Mahnoor Ahmad, Joseph D. Hovey, Isabella A. Cruz, Monica E. Ochoa, Nadeen Salhadar, Laura D. Seligman

Psychological Science Faculty Publications

Efficient and accurate screening tools are crucial for improving early identification and treatment outcomes among individuals with obsessive-compulsive disorder (OCD). This study evaluated the sensitivity and specificity of two OCD screening measures: the Obsessive-Compulsive Inventory-4 (OCI-4) and the Florida Obsessive-Compulsive Inventory-II (FOCI-II) severity scale. The measures were administered in a large transnational sample of Spanish speaking Latin American adults (N = 1696) with elevated obsessive-compulsive symptomatology. Participants completed diagnostic interviews (MINI and Y-BOCS) and self-report assessments across 23 sites in 11 countries. Both measures significantly distinguished OCD from non-OCD cases, with the FOCI-II demonstrating somewhat better predictive performance (AUC = …

Impact Of Cyp2d6 Genotype And Inhibitor Use On Risperidone Metabolism In Children: Functional Insights Into The *17 And *29 Alleles, Matthew H. Bennett, Ethan A. Poweleit, Samuel E. Vaughn, Brandon Retke, Paul Toren, Jeffrey R. Strawn, Laura B. Ramsey

Student Publications

Risperidone, an atypical antipsychotic, is increasingly prescribed in pediatric patients with psychiatric disorders. It is primarily metabolized by CYP2D6 to 9-hydroxyrisperidone, an active metabolite associated with a higher risk of adverse effects. The CYP2D6*17 and *29 alleles are prevalent in individuals of African ancestry and less studied than variants found in European ancestry individuals. This knowledge gap contributes to differences in health outcomes in individuals of non-European origin. The primary objective of this study is to replicate recently identified risperidone-specific activity for the CYP2D6*17 and *29 alleles. During psychiatric hospitalization, CYP2D6 was genotyped as part of routine care. Remnant plasma …

Systematic, Bibliographic And Statistical Aspects On Multi Generation Recycled Concrete Materials Research: A Review, Henrique Comba Gomes, Maozhou Meng, Katie Jones, William Vevers, Aissa Bouaissi, Boksun Kim

School of Engineering, Computing and Mathematics

This article aimed to review the current literature related to the topic of multiple generation recycled concrete materials considering systematic, bibliographic and statistical aspects. The review was conducted from an adaptation from the systematic review for engineering and experiments (SREE) method. Papers wrote in English with scientific relevance, title and abstract full aligned with the topic were selected from Scopus and Web of Science databases. Bibliographic aspects highlighted the research novelty, the quality of research and prominence for future works. The systematic review aimed to provide insights in the literature concerning multiple recycling concrete materials. Some of the main aspects …

Quality Of Human-Genai Collaboration And Its Driving Factors: A Symbiotic Agency Perspective, Jiayu Shang, Dan Huang, Songshan (Sam) Huang

Research outputs 2022 to 2026

Generative AI (GenAI) is increasingly integrated into users’ daily work as a collaborative partner. Drawing on the symbiotic agency theory, this study investigates the quality of human-GenAI collaboration using a mixed-methods approach, including qualitative interviews and quantitative surveys. Study 1 identified three dimensions of human-GenAI collaboration quality that comprise outcome quality, comfort, and efficiency; and six driving factors which can be categorized under human agency (domain knowledge, desire for control, and domestication ability), and GenAI agency (communication ability, working memory, and long-term memory). Study 2 applied fuzzy-set qualitative comparative analysis (fsQCA) to explore configurations of the driving factors that lead …

A Multi-Dimensional Analysis Of Household Food Waste In The Republic Of Ireland: Drivers, Patterns, And Impacts, Courage Yaw Krah

Doctoral

Despite growing research on consumer food waste, existing efforts have fallen short of achieving meaningful reductions. This challenge has primarily been attributed to the complex behavioural and demographic diversity within populations, reflected in varying practices of food acquisition, storage, preparation, and disposal. In addition, there is a limited understanding of the broader impacts of discarded food, particularly the environmental, economic, and nutritional losses. This results in an oversimplified view of HFW and leads to less effective intervention strategies. An integrated assessment that incorporates environmental, nutritional, and economic consequences can provide a more holistic representation of the problem and support the …

Temperature Dependence Of The Imaging Properties Of Holographic Lenses, Tomás Lloret, Jorge Lasarte, Suzanne Martin, Izabela Naydenova, Inmaculada Pascual

Research Outputs: 2025-Present

The demand for advanced photonic technologies to enhance augmented reality (AR) devices has led to a significant interest in new optical materials suitable for operation in sometimes challenging environmental conditions, such as elevated temperatures levels. Holographic optical lenses (HOLs), fabricated using holographic recording, offer several advantages over traditional refractive lenses, including greater versatility, lower cost, lower weight, and increased adaptability. In this study, we investigated the optical and thermal performance of HOLs recorded on four different photosensitive materials: Bayfol HX200, Bayfol HX120, a PVA/acrylamide-based photopolymer (AA/PVA), and a photopolymerisable hybrid sol–gel (PHSG). The lenses were exposed to thermal cycles 20 …

Design, Testing, And Safety Performance Of Movable Guardrail Systems: A Prisma-Based Systematic Review, Navid Hashemi Taba, Ahdieh Sadat Khatavakhotan, Majid Tolouei-Rad

Research outputs 2022 to 2026

Movable guardrail systems are increasingly used in work zones, reversible lanes, and temporary traffic operations; however, evidence on their crashworthiness, material performance, and operational reliability remains dispersed across multiple design typologies and regulatory frameworks. This PRISMA-compliant systematic review synthesizes 78 studies involving full-scale crash tests, validated finite-element simulations, field performance evaluations, and compliance evaluations under MASH, EN 1317, NCHRP 350, and AS/NZS 3845.1. The findings indicate that modular rigid barriers reliably achieve TL-3/TL-4 performance when joint alignment and foundation conditions are properly controlled; semi-rigid steel systems provide a practical balance between containment capacity and redeployability, but remain sensitive to post …

Risk Management Strategies Used By Project Leaders In Construction Projects On The East Coast, Dylan David Decuffa

Construction Management

Construction projects are often defined by their visible outcomes, structures completed on time, within budget, and built to the required standards. Yet beneath these outcomes lies a less visible force that quietly shapes whether success is achieved or compromised. Uncertainty is present in every phase of construction, influencing decisions, performance, and ultimately the trajectory of the project. The ability to recognize and respond to this uncertainty may separate projects that proceed with stability from those that experience delays, escalating costs, and diminished quality. Project managers, superintendents, project engineers, and other related fields play a central role in navigating this uncertainty …

Thousand Hills Pet Resort Ada Compliant Access Ramp And Connecting Deck: Preconstruction Activities, Sonya Nahama Wijoyo

Construction Management

This paper presents the design and preconstruction of an ADA-compliant access ramp and connecting deck system for two mobile homes located at Thousand Hills Pet Resort. The primary objective was to enhance accessibility and safety for residents by providing code-compliant, durable, and functional access to the mobile homes on site. This project is interdisciplinary between construction management and architectural engineering. The project began with a site evaluation to assess existing conditions. Field measurements and site observation guided planning decisions and helped identify potential challenges. Following the site evaluation, the project proceeded into the design phase, where the ramp and deck …

Prior Head Circumference Measurements In Infants With Older Subdural Hematomas: Did We Miss It?, Maryann Alvarez Griffis, Nancy D. Kellogg, Wouter Koek

School of Medicine Publications

Objective: To establish whether infants with macrocephaly and non-acute subdural hematomas (SDHs) had missed opportunities for measuring fronto-occipital circumference (FOC) and obtaining neuroimaging prior to diagnosis. Macrocephaly due to SDH in infancy is initially detected by FOC measurements and/or neuroimaging, as neurologic symptoms may be subtle or missed.

Methods: Retrospective chart review of infants with macrocephaly and non-acute SDHs referred to child abuse pediatricians for suspected abusive head trauma (AHT) over an 8-year period. A study sample of 35 infants met inclusion criteria and had complete prior medical records which were reviewed for missed opportunities for earlier SDH diagnosis. Four …

Stard-Net: Spatiotemporal Attention For Robust Detection Of Tiny Airborne Objects From Moving Drones, Hasibur Rahman, Sanjay Kumar Madria

Computer Science Faculty Research & Creative Works

The rapid adoption of drones across various domains, alongside advancements in computer vision, has driven growing interest in vision-based airborne object detection from moving aerial platforms. However, this task remains challenging due to the small scale of objects, camouflage within cluttered backgrounds, and occlusions. To address these challenges, we introduce an end-to-end detection framework that integrates a Drone Receptive Field Block (DRFB) to extract multiscale and geometrically diverse features, specifically designed to enhance the detection of small and camouflaged airborne objects. To model motion patterns over time while preserving spatial structure, particularly for detecting camouflaged, cluttered and occluded objects with …

Intramolecular Nonbonding Interactions And Geared Phenyl Twisting In Para-Disubstituted 1,4-Diphenylazines: Electron Correlation Effects On Molecular Conformations And Enantiomerization, Kaidi Yang, Harmeet Bhoday, Rainer Glaser

Chemistry Faculty Research & Creative Works

The results are reported of potential energy surface (PES) analyses of six symmetrical azines Y_p − Ph − RC=N − N=CR − Ph − Y_p, namely, the benzaldehyde azines 1H, 2H, and 8H with R = H and the acetophenone azines 1M, 2M, and 8M with R = Me. The Y substituents Cl (1), Br (2), and Me (8) were studied because sets of polymorphs I (C2-symmetry, azine twist τ ≈ 135 ± 10°, disrotatory phenyl twists ϕi ≠ 0°) and II (Ci-symmetry, τ = 180°, conrotatory ϕi ≠ 0°) were crystallized for these three azines. The …

Compensation For Victims Of Crimes: Should Victims’ Financial Means And Insurance Coverage Matter? — Criminal Procedure Code 2010, S 359(1); Public Prosecutor V Ong Eng Siew [2025] Sghc 55, Benjamin Joshua Ong

Research Collection Yong Pung How School Of Law

Under s 359(1) of the Criminal Procedure Code 2010, the court can order an offender to compensate the victim with a sum which the victim would have been able to recover in a civil claim in tort against the offender. The courts have used this useful power extensively, though problems remain. One such problem is seen in Ong Eng Siew, where the court declined to make a compensation order. Given the purpose of the compensation system, the court was not correct to hold – in effect – that the purpose of s 359(1) is to benefit only impecunious victims, and …

Spatial Profiling Reveals Distinct Molecular And Immune Evolution Of Mouse Lung Adenocarcinoma Precancers With Or Without Carcinogen Exposure, Bo Zhu, Muhammad Aminu, Pingjun Chen, Jian-Rong Li, Chuanpeng Dong, Chenyang Li, Yanhua Tian, Shao-Wei Lu, Hong Chen, Chenxi Ma, Xin Hu, Jie Ye, Andrew Y Liu, Beibei Huang, Frank R Rojas, Parra Cuentas Edwin Roger, Ou Shi, Monique B Nilsson, Alissa Poteete, Khaja B Khan, Wei Lu, Luisa M Solis Soto, Junya Fujimoto, Cara Haymaker, Ignacio I Wistuba, Zhubo Wei, Linghua Wang, Don L Gibbons, Ken Chen, Alexandre Reuben, Jason M Schenkel, John V Heymach, Chao Cheng, Jia Wu, Jianjun Zhang

Faculty, Staff and Student Publications

Tumor evolution involves genetic, transcriptional, and phenotypic alterations that shape cancer cell behavior and interactions with the microenvironment. While single‐cell technologies have advanced our understanding of this process, spatial dynamics remain incompletely characterized. Here, whole‐exome sequencing (WES), imaging mass cytometry (IMC), and spatial transcriptomics (ST) were integrated to study molecular evolution and immune responses in two lung adenocarcinoma (LUAD) mouse models: a genetically engineered model (129S4/Sv‐KrasLSL‐G12D, termed 129S4 K) and a carcinogen‐induced precancer model (129S4 U). Compared to 129S4 K, 129S4 U tumors exhibited higher mutational, neoantigen but lower copy number variation (CNV) burdens at matched developmental timepoints, consistent with …

Non-Synaptic Function And Localization Of Syntaxin-Binding Protein 1 In A Mouse Model Of Stxbp1-Related Epileptic Encephalopathy, Tao Yang, Rajat Banerjee, Yamei Deng, Sheetal Jahagirdar, Joo Hyun Kim, Wu Chen, Mingshan Xue, Alexey I Nesvizhskii, Michael D Uhler, Jack M Parent, Yu Wang

Duncan NRI Faculty and Staff Publications

Objective: De novo mutations in the syntaxin-binding protein 1 (STXBP1), encoded by STXBP1, are among the most prevalent causes of variable neurodevelopmental disorders, including epileptic encephalopathy, developmental delay, and movement disorders. Although STXBP1 has been proposed as a critical presynaptic protein controlling synaptic vesicle exocytosis, clinical phenotypes also suggest that its biological function could be more diverse.

Methods: The expression pattern of STXBP1 was studied using immunostaining in vitro and in vivo. Synaptosome isolation was performed to investigate the synaptic and non-synaptic localization of STXBP1 in the brain. STXBP1 immunoprecipitation followed by mass spectrometry (MS) was conducted to identify protein …

Long-Term Consumer Welfare, Rebecca Haw Allensworth

Vanderbilt Law Review

Consumer welfare is not monolithic. Antitrust policy that pursues it as a goal must trade off the various incommensurable values that make up the consumer experience. Perhaps the most important of these-and the most poorly theorized-is the trade-off between consumers' short-term and long-term welfare. Many business practices that might be challenged as exclusionary or unreasonable restraints of trade can benefit consumers on one time horizon while hurting them on another. Often the trade-off is between short-term quality or price effects and long-term consequences for competitive entry and incentives to innovate. These disparate effects are well understood by economists, yet economics …

Beyond Redemption?: Examining The Sixth Circuit’S Dangerousness Approach For As-Applied Challenges To The Felon-In-Possession Ban, Jack Baker

Vanderbilt Law Review

The federal felon-in-possession statute permanently bans felons from possessing firearms, regardless of the severity of the predicate felony conviction. Both a murder conviction and a mail-fraud conviction equally satisfy the statute's elements. Critics thus argue that the statute is too expansive. Despite the criticism, the felon-in-possession ban has generally survived Second Amendment challenges. But the U.S. Supreme Court's decision in New York State Rifle & Pistol Ass'n v. Bruen opened a new angle for constitutional challenges to the felon-in-possession ban. In Bruen, the Supreme Court established a history-and-tradition test for Second Amendment cases. Courts must now find historically analogous gun …

When Detention Becomes A Death Sentence: The Urgent Need For Greater Due Process Protections For Ice Detainees, Kyle J. Smith

Vanderbilt Law Review

This Note argues that U.S. immigration detention, though legally classified as civil, operates as a punitive carceral system that routinely subjects immigrants to abuse, neglect, and preventable death. Drawing on the tragic case of Ernesto Javier Rocha Cuadra and other documented instances of physical violence, medical neglect, solitary confinement, and sexual abuse, it demonstrates how U.S. Immigration and Customs Enforcement ('ICE') relies on detention as a default mechanism rather than as a last resort. The result is a system that mirrors the criminal legal system in scale and severity but denies detainees its constitutional safeguards.
The analysis situates the rise …

Thermodynamically Consistent Incorporation Of The Langmuir Adsorption Model Into Compressible Fluctuating Hydrodynamics, Hyun Tae Jung, Hyungjun Kim, Alejandro L. Garcia, Andrew J. Nonaka, John B. Bell, Ishan Srivastava, Changho Kim

Faculty Research, Scholarly, and Creative Activity

For a gas–solid interfacial system where chemical species undergo reversible adsorption, we develop a mesoscopic stochastic modeling method that simulates both gas-phase hydrodynamics and surface coverage dynamics by coupling the Langmuir adsorption model with compressible fluctuating hydrodynamics. To this end, we derive a thermodynamically consistent mass–energy update scheme that accounts for how the mass and energy variables in the gas and surface subsystems should be updated according to the changes in the number of molecules of each species in each subsystem due to adsorption and desorption events. By performing a stochastic analysis for the ideal Langmuir model and the full …

Ultrarenderer: Real-Time Heterogeneous Cpu-Gpu Memory Management And Adaptive View-Dependent Rendering For Massive 3d Environments, Huadong Zhang

Theses

Rendering large-scale 3D datasets in real-time presents significant challenges due to the widening gap between the ever-growing scale of dataset complexity and the limited memory capacity of modern GPUs. As datasets increasingly exceed available GPU memory, traditional methods encounter severe bottlenecks, such as restricted CPU-GPU bandwidth and inefficient memory usage, which significantly hinder rendering performance. This is especially problematic in interactive applications where high frame rates and low latency are critical. To address these limitations, this dissertation presents UltraRenderer, a novel out-of-core rendering method designed to maximize visual fidelity under strict memory and bandwidth constraints. The core of our approach …

Online Age Gating: An Interdisciplinary Evaluation, Noah Apthorpe, Brett Frischmann, Yan Shvartzshnaider

Faculty Publications

The recent surge in regulation seeking to establish age-based governance online is part of a decades-long attempt to establish online zoning. It is driven by active development of technologies to estimate or verify user age based on various characteristics of users, their credentials, or their activities. However, these developments have heightened prevailing concerns that online age gating technology will inevitably be abused and misused to cause a variety of privacy harms and rights infringements. This paper examines this ongoing debate by bridging technical and legal scholarship to explore the current state of online age-based governance. We discuss the current legal …

La Françafrique: À La Lumière Des Romans Et Films Francophones, Joseph Diémé

Trade & Scholarly Monographs

Qu’est-ce que la Françafrique? Qui sont ses acteurs? Où et comment opèrent-ils? Cet ouvrage tente de répondre à ces questions complexes à la lumière d’essais politiques, de romans et films de pays francophones. Pas à pas, le lecteur découvre comment la fiction offre un cadre pertinent non seulement pour comprendre le concept « Françafrique », mais aussi pour identifier quelques-unes de ses ramifications sur le continent africain.

An Analysis Of Injury And Fatality Trends In The U.S. Construction Industry, Ryan Dutt

Construction Management

Construction work is one of the most dangerous industries in the United States, with different trades and work types showing various risk levels for injuries and fatalities. This paper’s objective is to identify the safety trends in construction over the past 10 to 20 years and understand the trades, accident types, and construction sectors with the highest safety risks. All of the data was obtained from the Occupational Safety and Health Administration (OSHA), the Bureau of Labor Statistics (BLS), the National Institute for Occupational Safety and Health (NIOSH), and the National Safety Council (NSC) databases, broken down by trade, accident …

From Concept To Construction: A Carport For The Slo Botanical Garden, Trent A. Denholm

Construction Management

This paper documents the design, budgeting, procurement and construction of a timber framed carport with architectural shingle roofing at the San Luis Obispo Botanical Garden (SLOBG). The Botanical Garden, a nonprofit organization dependent on community support and volunteer labor, identified the need for covered storage and a dedicated charging station for its golf cart, a vehicle central to daily operations across the property. Without permanent shelter, the cart was exposed to the elements year-round, which contributed to equipment wear and reduced operational efficiency. Working simultaneously as project manager and lead builder, Trent coordinated stakeholder relationships, developed a project budget, secured …

Residential Boundary Fence Installation In Oceano, Ca, Ulysses Beas

Construction Management

This Senior Project focuses on the planning and execution of a residential boundary wooden fence for an elderly homeowner located in Oceano, California, alongside a partial front yard renovation that was an appreciation gift from her grandson. Prior to construction, the front yard was divided by a small ornamental iron fence, which provided very little privacy. This fence installation was designed to improve privacy, security and overall safety while working alongside hired concrete laborers. Not only was the goal to improve safety but also the aesthetics of the home. This Project includes a project scope statement, site measurements, fence layout, …

The Impact Of Bilingual Superintendents On A Multilingual Job Site, Cesar Barajas

Construction Management

Language barriers are frequently encountered on construction job sites. Construction crews can often be limited in their proficiency when speaking English and in states like California, construction superintendents oversee a lot of Spanish-speaking crews. This study aims to identify if bilingual superintendents lead to better performing projects. Communication impacts major metrics of project performance including schedule, rework costs, safety performance, and coordination across trades. This qualitative study includes superintendents, project managers, and field crew semi structured interviews backed by survey answers. Interview participants discuss specific examples of how communication can affect jobsite performance both negatively and positively. Subjects are asked …

Hes V2.0 Validation And Performance Compared To Galad And Asap In The Heds Cohort, Hashem B El-Serag, Camden Lopez, Michelle Luster, K Rajender Reddy, Neehar Parikh, Amit G Singal, Jorge A Marrero, Aaron P Thrift, Jagpreet Chhatwal, Ziding Feng, Stephanie Page-Lester, Qingchun Jin, Nabihah Tayob, Fasiha Kanwal

Faculty, Staff and Students Publications

Background & aims: We previously developed HES V2.0, a biomarker panel (age, ALT, platelets, etiology, AFP, AFP-L3, DCP, and their 1-year gradients) for early detection of hepatocellular carcinoma (HCC) among patients with cirrhosis. We externally validated HES V2.0 and compared its performance with HES V1.0, GALAD, and ASAP.

Methods: We conducted a PRoBE (prospective specimen-collection, retrospective blinded-evaluation) cohort study in the HEDS (Hepatocellular Carcinoma Early Detection Strategy) cohort of 1,485 patients with cirrhosis, of whom 119 developed HCC. Patient- and test-level true positive rates (TPR) for HCC were calculated at 6, 12, and 24 months before diagnosis, using thresholds at …

Predominant Symptom In Gastroparesis: Relationships To Quality Of Life, Treatments, And Outcome, Henry P Parkman, Laura A Wilson, William L Hasler, Madhusudan Grover, Bruno P Chumpitazi, Helen Burton-Murray, Irene Sarosiek, Baha Moshiree, Geoffrey A Preidis, Robert J Shulman, Laura A Miriel, Dave Shade, Braden Kuo, Richard W Mccallum, Thomas L Abell, Pankaj J Pasricha

Faculty, Staff and Students Publications

Background: Patients with gastroparesis (Gp) can have a variety of symptoms. Apart from use of prokinetics, symptomatic therapies for the predominant symptom (PrS) are used.

Aims: (1) To classify Gp patients based on their PrS; (2) To determine differences in Gp symptoms, gastric emptying (GE), quality of life (QOL), treatments, and symptom improvement among Gp patients with different PrS.

Methods: Gp patients were enrolled in a multicenter registry and followed for 96-weeks. Patients recorded their PrS and completed questionnaires assessing symptoms and QOL at enrollment and at follow up visits.

Results: Of 1013 Gp patients (361 diabetic, 607 idiopathic, 45 …