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Development Of Functional Markers For Resistance To Smut And Identification Of Genes Differentially Expressed In Response To Brown Rust In Sugarcane, Jose David Cortes Dec 2022

Development Of Functional Markers For Resistance To Smut And Identification Of Genes Differentially Expressed In Response To Brown Rust In Sugarcane, Jose David Cortes

LSU Doctoral Dissertations

Smut, caused by Sporisorium scitamineum and brown rust, caused by Puccinia melanocephala, are two of the most important diseases that affect sugarcane production in Louisiana and worldwide. Smut continues to cause losses in the breeding program in Louisiana. Therefore, a QTL analysis was conducted to identify molecular markers associated with resistance in F1 progeny (162) of a biparental cross between susceptible cultivar L 99-233 and resistant HoCP 96-540. Using 1,574 single-dose SNP markers, a total of 253 linkage groups (LG) were obtained with a genome coverage of 24,580.15 cM. Six QTLs were localized on five LGs. The highest …


The Spectral Sensitivity Of Human Circadian Phase Resetting And Melatonin Suppression To Light Changes Dynamically With Light Duration, Melissa A. St Hilaire, María L. Ámundadóttir, Shadab A. Rahman, Shantha M. W. Rajaratnam, Melanie Rüger, George C. Brainard, Charles A. Czeisler, Marilyne Andersen, Joshua J. Gooley, Steven W. Lockley Dec 2022

The Spectral Sensitivity Of Human Circadian Phase Resetting And Melatonin Suppression To Light Changes Dynamically With Light Duration, Melissa A. St Hilaire, María L. Ámundadóttir, Shadab A. Rahman, Shantha M. W. Rajaratnam, Melanie Rüger, George C. Brainard, Charles A. Czeisler, Marilyne Andersen, Joshua J. Gooley, Steven W. Lockley

Department of Neurology Faculty Papers

Human circadian, neuroendocrine, and neurobehavioral responses to light are mediated primarily by melanopsin-containing intrinsically-photosensitive retinal ganglion cells (ipRGCs) but they also receive input from visual photoreceptors. Relative photoreceptor contributions are irradiance- and duration-dependent but results for long-duration light exposures are limited. We constructed irradiance-response curves and action spectra for melatonin suppression and circadian resetting responses in participants exposed to 6.5-h monochromatic 420, 460, 480, 507, 555, or 620 nm light exposures initiated near the onset of nocturnal melatonin secretion. Melatonin suppression and phase resetting action spectra were best fit by a single-opsin template with lambdamax at 481 and 483 …


A New Gtseq Resource To Facilitate Multijurisdictional Research And Management Of Walleye Sander Vitreus, Peter T. Euclide, Wesley A. Larson, Matthew Bootsma, Loren M. Miller, Kim T. Scribner, Wendylee Stott, Chris C. Wilson, Emily K. Latch Dec 2022

A New Gtseq Resource To Facilitate Multijurisdictional Research And Management Of Walleye Sander Vitreus, Peter T. Euclide, Wesley A. Larson, Matthew Bootsma, Loren M. Miller, Kim T. Scribner, Wendylee Stott, Chris C. Wilson, Emily K. Latch

Purdue University Libraries Open Access Publishing Fund

Conservation and management professionals often work across jurisdictional boundaries to identify broad ecological patterns. These collaborations help to protect populations whose distributions span political borders. One common limitation to multijurisdictional collaboration is consistency in data recording and reporting. This limitation can impact genetic research, which relies on data about specific markers in an organism's genome. Incomplete overlap of markers between separate studies can prevent direct comparisons of results. Standardized marker panels can reduce the impact of this issue and provide a common starting place for new research. Genotyping-in-thousands (GTSeq) is one approach used to create standardized marker panels for nonmodel …


Regional Airline Pilot Profession Post Colgan 3407, Brett Maas Dec 2022

Regional Airline Pilot Profession Post Colgan 3407, Brett Maas

Honors Theses

Colgan Air Flight 3407 was a devastating aircraft accident that resulted in the loss of 50 lives (Beresnevicius, 2019). Multiple factors played into the accident, such as pilot credentials, pilot experience, weather, and fatigue. As a result of the accident, the regional airline pilot profession was changed entirely. Changes that spurred because of the accident were both regulatory and compensatory in nature. Regulatory changes include the introduction of the Pilot Records Database (online database that stores pilot training histories), increased flight experience requirements to become a First Officer at an air carrier, and the introduction of proactive rest rules with …


Bob Reich Oral History Interview, Bob Reich, Mathew Lin Dec 2022

Bob Reich Oral History Interview, Bob Reich, Mathew Lin

Raymond College

No abstract provided.


Teaching Autistic Children To Independently Wash Their Hands: A Systematic Review Of Behavioral Techniques, Alexis Vazquez Dec 2022

Teaching Autistic Children To Independently Wash Their Hands: A Systematic Review Of Behavioral Techniques, Alexis Vazquez

Seton Hall University Dissertations and Theses (ETDs)

With COVID 19 having changed the world’s perception on daily hygiene, people are aiming to improve the rate and efficacy of their hand washing. Autistic children, having a history of challenges with daily living skills, may need support when learning the skill of hand washing. The current review discusses interventions used to teach autistic children effective hand washing and investigates if those interventions meet criteria to be considered an evidence-based practice. Six studies met the inclusion criteria and data were synthesized narratively. Given the importance of hand washing in society, more research is necessary to achieve optimal outcomes. The review …


Understanding The Experiences Of African American Caregivers Of Loved Ones With Dementia, Paula R. Madison Dec 2022

Understanding The Experiences Of African American Caregivers Of Loved Ones With Dementia, Paula R. Madison

Seton Hall University Dissertations and Theses (ETDs)

Background: Dementia is a public health problem that is estimated to triple by 2050.Globally, dementia is the seventh leading cause of death among all diseases and one of the major causes of disability and dependency among older people. The direct medical costs and indirect social and economic costs of dementia are burdensome to society, and by 2030 it is projected to cost more than $2.8 TRILLION dollars worldwide. African Americans are two to four times more likely to be diagnosed with dementia than White Americans; and more likely to rely on informal care from family and friends. African …


Single-Shot, Ultrafast, Multi-Frame X-Ray Imaging Of Defect-Bearing Ablator Materials In Extreme Conditions, Daniel S. Hodge Dec 2022

Single-Shot, Ultrafast, Multi-Frame X-Ray Imaging Of Defect-Bearing Ablator Materials In Extreme Conditions, Daniel S. Hodge

Theses and Dissertations

Characterization of the dynamic behavior of defect-bearing ablator materials subjected to extreme conditions is essential in advancing fusion energy as an reliable and abundant energy source. By understanding how materials evolve spatially and temporally we can minimize hydrodynamic instabilities, which are major contributing factors to energy yield degradation in inertial confinement fusion (ICF) experiments. In this thesis we demonstrate the capabilities of an ultrafast x-ray imaging (UXI) detector, the Icarus V2, where we capture multiple frames of single void-bearing sample compressed by a high-intensity laser shockwave. Using the Matter in Extreme Conditions (MEC) instrument at the Linac Coherent Light Source …


Delivering Explicit Math Instruction Through Point-Of-View Video Modeling To Elementary Students With Autism Spectrum Disorder, Patsy Mccray Gibbs Dec 2022

Delivering Explicit Math Instruction Through Point-Of-View Video Modeling To Elementary Students With Autism Spectrum Disorder, Patsy Mccray Gibbs

Theses and Dissertations

There is significant literature demonstrating the effectiveness of video modeling for teaching skills to students with disabilities. Still, much less is known about how video modeling, particularly point-of-view video modeling (POV-VM), might be applied to teach academic skills to children with an autism spectrum disorder. This multiple probe single-case design study used explicit instruction techniques to teach multiplication, division, and fraction skills to two elementary-aged students with an autism spectrum disorder. A visual analysis of the data showed that POV-VM using explicit techniques to deliver the videos is an effective intervention for autistic students This research study adds to the …


Decision-Based Learning As A Tool For Teaching Statistics In A Peruvian University, Gloria Mora Barba Dec 2022

Decision-Based Learning As A Tool For Teaching Statistics In A Peruvian University, Gloria Mora Barba

Theses and Dissertations

Many students find that learning statistics is difficult, especially novice learners first taking statistical classes. Instructors also struggle to teach statistics due to many challenges, such as students' misconceptions, lack of math skills, negative attitudes, and deficient instructional methods. A new pedagogical approach called Decision-Based Learning (DBL) has been developed to help instructors and students overcome these challenges. A group of Peruvian university professors in 2018 and 2019 were trained to use DBL. However, limited studies have explored DBL instructors' and students' experiences using DBL in Peru. The aim of this qualitative research study is to deeply understand the experiences …


Quantifying Shape Variation In An Antisymmetrical Trait In Xenophallus Umbratilis, Mary-Elise Johnson Nielsen Dec 2022

Quantifying Shape Variation In An Antisymmetrical Trait In Xenophallus Umbratilis, Mary-Elise Johnson Nielsen

Theses and Dissertations

Antisymmetry is a striking, yet puzzling form of biological asymmetry. The livebearing fish Xenophallus umbratilis exhibits antisymmetry in the male intromittent organ and provides a system that is well-suited for studying the nature of variation in antisymmetrical traits. Using geometric morphometrics, I test the hypothesis that because the gonopodium is critical to fitness there will not be significant differences in gonopodium shape between the two gonopodial morphs in this species. My results are consistent with this prediction, though I found that gonopodium shape did differ with gonopodium size.


Gabapentin Disrupts Binding Of Perlecan To The Α 2Δ1 Voltage Sensitive Calcium Channel Subunit And Impairs Skeletal Mechanosensation, Perla C Reyes Fernandez, Christian S Wright, Adrianna N Masterson, Xin Yi, Tristen V Tellman, Andrei Bonteanu, Katie Rust, Megan L Noonan, Kenneth E White, Karl J Lewis, Uma Sankar, Julia M Hum, Gregory Bix, Danielle Wu, Alexander G Robling, Rajesh Sardar, Mary C Farach-Carson, William R Thompson Dec 2022

Gabapentin Disrupts Binding Of Perlecan To The Α 2Δ1 Voltage Sensitive Calcium Channel Subunit And Impairs Skeletal Mechanosensation, Perla C Reyes Fernandez, Christian S Wright, Adrianna N Masterson, Xin Yi, Tristen V Tellman, Andrei Bonteanu, Katie Rust, Megan L Noonan, Kenneth E White, Karl J Lewis, Uma Sankar, Julia M Hum, Gregory Bix, Danielle Wu, Alexander G Robling, Rajesh Sardar, Mary C Farach-Carson, William R Thompson

Faculty, Staff and Student Publications

Our understanding of how osteocytes, the principal mechanosensors within bone, sense and perceive force remains unclear. Previous work identified "tethering elements" (TEs) spanning the pericellular space of osteocytes and transmitting mechanical information into biochemical signals. While we identified the heparan sulfate proteoglycan perlecan (PLN) as a component of these TEs, PLN must attach to the cell surface to induce biochemical responses. As voltage-sensitive calcium channels (VSCCs) are critical for bone mechanotransduction, we hypothesized that PLN binds the extracellular α2δ1 subunit of VSCCs to couple the bone matrix to the osteocyte membrane. Here, we showed co-localization of PLN and α2δ1 along …


Clinical Characteristics And Electrophysiologic Properties Of Scn5a Variants In Fever-Induced Brugada Syndrome, Gan-Xiao Chen, Hector Barajas-Martinez, Giuseppe Ciconte, Cheng-I Wu, Michelle M Monasky, Hao Xia, Bian Li, John A Capra, Kai Guo, Zhong-He Zhang, Xiu Chen, Bo Yang, Hong Jiang, Gary Tse, Chloe Miu Mak, Yoshiyasu Aizawa, Michael H Gollob, Charles Antzelevitch, Arthur A M Wilde, Carlo Pappone, Dan Hu Dec 2022

Clinical Characteristics And Electrophysiologic Properties Of Scn5a Variants In Fever-Induced Brugada Syndrome, Gan-Xiao Chen, Hector Barajas-Martinez, Giuseppe Ciconte, Cheng-I Wu, Michelle M Monasky, Hao Xia, Bian Li, John A Capra, Kai Guo, Zhong-He Zhang, Xiu Chen, Bo Yang, Hong Jiang, Gary Tse, Chloe Miu Mak, Yoshiyasu Aizawa, Michael H Gollob, Charles Antzelevitch, Arthur A M Wilde, Carlo Pappone, Dan Hu

Division of Cardiology Faculty Papers

Background: Brugada syndrome (BrS) is a severe inherited arrhythmia syndrome that can be unmasked by fever.

Methods: A multicentre clinical analysis was performed in 261 patients diagnosed with fever-induced BrS, including 198 (75.9%) and 27 (10.3%) patients who received next-generation genetic sequencing and epicardial arrhythmogenic substrate (AS) mapping, respectively.

Findings: In fever-induced BrS patients, pathogenic or likely pathogenic (P/LP) SCN5A variant carriers developed fever-induced BrS at a younger age, and more often in females and those of Caucasian descent. They exhibited significant electrophysical abnormalities, including a larger epicardial AS area, and more prolonged abnormal epicardial electrograms. During a median follow-up …


A Phenomenological Study Of Collegiate Recovery Leadership, Marni Goldberg Dec 2022

A Phenomenological Study Of Collegiate Recovery Leadership, Marni Goldberg

Teacher Education, Educational Leadership & Policy ETDs

Due to the marginalized status of the population they serve, collegiate recovery programs are generally underfunded and employ one staff member who typically holds other job tasks in addition to those of collegiate recovery leader. The consequence of the varied nature by which collegiate recovery programs are founded and implemented is inconsistency, which can threaten the longevity of the field. The purpose of this phenomenological study was to elicit information directly from collegiate recovery leaders to gain a deeper understanding of their lived experience, in order to determine how to best serve and support higher education students in recovery from …


The Effect Of Climate Change On Firm Level Costs With Focus On Mena Region, Farah Osama Saieed Dec 2022

The Effect Of Climate Change On Firm Level Costs With Focus On Mena Region, Farah Osama Saieed

Theses and Dissertations

This paper has a main objective of identifying the relationship between environmental factors and climate change on operating costs incurred by firms. This paper also attempts to compare the direction and intensity of the effect on different sectors in order to analyze whether climate change effect differs based on the nature of the business operations. Several papers have previously addressed the relationship between climate change factors ad profits. This literature will add to previous studies by observing the effect on the cost rather than the profits. In addition to providing results that minimize endogeneity, which is found in a large …


Polymer Reaction Engineering Xi, Timothy Mckenna, Markus Busch, Jay Reimers, Brian Greenhalgh, Claudia Sayer, Robin Hutchinson, Joe Schork, Jose Ramon Leiza, John Tsavalas Dec 2022

Polymer Reaction Engineering Xi, Timothy Mckenna, Markus Busch, Jay Reimers, Brian Greenhalgh, Claudia Sayer, Robin Hutchinson, Joe Schork, Jose Ramon Leiza, John Tsavalas

Polymer Reaction Engineering XI (2022)

No abstract provided.


Therapeutic Approaches Applied To A Middle School Art Unit, Alisa Burggraff Dec 2022

Therapeutic Approaches Applied To A Middle School Art Unit, Alisa Burggraff

Art 895 Research Papers

This case study begins with a brief description of my circumstances as a middle school art teacher, Social and Emotional Learning (SEL), the Collaborative for Academic, Social, and Emotional Learning (CASEL), and my research questions: How can art educators adapt CASEL/SEL within their art curriculum to improve students’ mental health and abilities to cope with stress and trauma? What specific therapeutic and CASEL Model procedures can be applied to an art curriculum that aids in the development of a child’s social and emotional development or learning? SEL and CASEL are defined and compared to art therapy/art therapy practices. A rationale …


Learning Through Social Media: A Case Study Of The Getty Center, Regan Fisher Dec 2022

Learning Through Social Media: A Case Study Of The Getty Center, Regan Fisher

Art 895 Research Papers

Social media is a powerful tool that allows for massive connectivity across the globe and is integral to how young people interact with each other and make sense of their world. During the COVID19 pandemic of 2020, social media was instrumental in connecting communities to museums and providing access during closures. This case study examines how The Getty Center in Los Angeles utilized social media with innovative, strategic thinking and engaging content to achieve their mission of educating the public and increasing awareness about the artifacts housed in their collection.


A Blockchain-Based Regulatory Framework For Mhealth, Dounia Marbouh, Mecit Can Emre Simsekler, Khaled Salah, Raja Jayaraman, Samer Ellahham Dec 2022

A Blockchain-Based Regulatory Framework For Mhealth, Dounia Marbouh, Mecit Can Emre Simsekler, Khaled Salah, Raja Jayaraman, Samer Ellahham

Industrial Engineering: Faculty & Staff Publications

Mobile health (mHealth) is playing a key role in facilitating health services for patients. Such services may include remote diagnostics and monitoring, chronic conditions management, preventive medicine, and health promotion. While mHealth has gained significant traction during the COVID-19 pandemic, they may pose safety risks to patients. This entails regulations and monitoring of shared data and management of potential safety risks of all mHealth applications continuously and systematically. In this study, we propose a blockchain-based framework for regulating mHealth apps and governing their safe use. We systematically identify the needs, stakeholders, and requirements of the current mHealth practices and regulations …


Encouraging Confident Art Making In The Primary Elementary Art Room, Morgan Hagan Dec 2022

Encouraging Confident Art Making In The Primary Elementary Art Room, Morgan Hagan

Art 895 Research Papers

This action research study observes artistic outcomes from students in kindergarten through third grade who display a range of artistic skill levels, and backgrounds. The purpose of this study is to explore what confidence looks like in student artwork and what pedagogical practices art teachers can use to help encourage that confidence by answering two central questions. What does confidence look like in student artwork? What pedagogical practices can art teachers use to encourage students to have confidence in art making?


Ken Moon, Oral History Interview, 2022, Chyelle Pitts-Chatman, Matt Jones Dec 2022

Ken Moon, Oral History Interview, 2022, Chyelle Pitts-Chatman, Matt Jones

Oral Histories

In the Fall of 2022, Matt Jones’s Oral History Techniques class conducted a set of interviews documenting the stories behind the student unrest on Eastern Michigan University’s campus from 1966-1972. Ken Moon was a Black administrator at EMU during the lates 1960s and early 1970s, and an important mediator between the students and the administration. Moon was an influential figure on campus and supported students academically and personally.


Certification Basis For A Fully Autonomous Uncrewed Passenger Carrying Urban Air Mobility Aircraft, Steve Price Dec 2022

Certification Basis For A Fully Autonomous Uncrewed Passenger Carrying Urban Air Mobility Aircraft, Steve Price

Student Works

The Urban Air Mobility campaign has set a goal to efficiently transport passengers and cargo in urban areas of operation with autonomous aircraft. This concept of operations will require aircraft to utilize technology that currently does not have clear regulatory requirements. This report contains a comprehensive analysis and creation of a certification basis for a fully autonomous uncrewed passenger carrying rotorcraft for use in Urban Air Mobility certified under Title 14 Code of Federal Regulations Part 27. Part 27 was first analyzed to determine the applicability of current regulations. The fully electric propulsion system and fully autonomous flight control system …


Heterogeneous Strain Distribution & The Effects Of High Frequency Climate Change On The Evolution Of Early-Stage Rift Systems: Case Studies From Lakes Tanganyika And Malawi (Nyasa), East Africa, Lachlan Wright Dec 2022

Heterogeneous Strain Distribution & The Effects Of High Frequency Climate Change On The Evolution Of Early-Stage Rift Systems: Case Studies From Lakes Tanganyika And Malawi (Nyasa), East Africa, Lachlan Wright

Dissertations - ALL

The break-up of the earth’s crust through the formation of continental rift basins is a fundamental aspect of plate-tectonics and the first step that ultimately leads to plate-spreading, new continent formation, and the creation of ocean basins. Within continental rifts, processes associated with extensional faulting drive uplift and subsidence of the landscapes forming rift valleys, and climatically influenced processes act upon these transient landscapes, erode them, modify relief, and produce sediments that infill the rift valleys creating the stratigraphic record. Continental rifts are highly sensitive to the interplay between extensional faulting, sedimentary processes, and climate change, and variations in the …


A Robust Random Forest Prediction Model For Mother-To-Child Hiv Transmission Based On Individual Medical History, Rebecca Chaula Dec 2022

A Robust Random Forest Prediction Model For Mother-To-Child Hiv Transmission Based On Individual Medical History, Rebecca Chaula

Tanzania Journal of Engineering and Technology (TJET)

Human Immunodeficiency Virus (HIV) continues to be a leading cause of mortality and reduces manpower throughout the world. HIV transmission from mother to child is still a global challenge in health research. According to UNAIDS, in every 7 girls, 6 are found to be newly infected among adolescents whereby 15-24 years are likely to be living with HIV which is the maternal age and likely to transfer to the child. Machine learning methods have been used to predict HIV/AIDS transmission from mother to child but left behind some important considerations including the use of patient-level information and techniques in balancing …


Modern And Information Services Of An Academic Library: An Overview, Bala Sankar B, Bala Sankar B Dec 2022

Modern And Information Services Of An Academic Library: An Overview, Bala Sankar B, Bala Sankar B

Library Philosophy and Practice (e-journal)

Academic libraries are considered a confidence centre of educational establishments and their Services assist numerous academic programs, including teaching and research. In academic libraries, the application of the latest technology, particularly internet technology, has transformed traditional methods of providing library and information services. Introducing novel information via a variety of channels requires an extra need for information and a library system to include the latest users. As users of technology became more demanding, libraries grew or invented new services. Information methods and techniques are constantly being developed by the internet for libraries to use to provide their services. Some research …


Investigating The Support For Agility In Developing Government Software Systems: A Case Of Three East African Countries, Leonard Peter Binamungu Dec 2022

Investigating The Support For Agility In Developing Government Software Systems: A Case Of Three East African Countries, Leonard Peter Binamungu

Tanzania Journal of Engineering and Technology (TJET)

Agile Software Development Methods support an iterative and incremental way of developing software systems while responding to change by prioritising various aspects at different times. This differs from traditional sequential methods like Waterfall, in which one software development stage has to be completed before starting the next stage. To produce software systems that meet the requirements of their institutions, several governments in Africa have issued standards and guidelines to be followed during the development of government software systems. Such standards and guidelines specify the specific activities and deliverables for each stage of software development. While well-intentioned, such guidelines and standards …


An Investigation Of Spirituality In Person-Centered Planning For Adults With Intellectual/Developmental Disabilities, Holly F. Pedersen, Jolynn Webster Dec 2022

An Investigation Of Spirituality In Person-Centered Planning For Adults With Intellectual/Developmental Disabilities, Holly F. Pedersen, Jolynn Webster

Journal of Sustainable Social Impact

While research identifies spirituality and inclusion in a community of faith as key factors contributing to quality of life for many individuals in our society, people with disabilities are often not able to access this aspect of everyday life if they wish. To change this, four groups must come together: (1) individuals with disabilities; (2) faith communities; (3) families of people with disabilities; and (4) support service providers. Current research describes the efforts of faith communities and people with disabilities and their families relative to spiritual inclusion; however, little is known about how support service systems are addressing this topic. …


Examining Teaching Practices That Increase Student Mathematical Achievement, Jonah P. Zimmerman Dec 2022

Examining Teaching Practices That Increase Student Mathematical Achievement, Jonah P. Zimmerman

Masters Projects

The current data in the United States surrounding mathematics shows that there are issues that must be addressed with teaching and learning math in the K-12 setting. In the perfect world, all students would meet grade level expectations in math prior to moving to another grade; however, this is not what is taking place. Students are not meeting proficiency, and as a result teachers and students alike are not gaining confidence in teaching/learning mathematics. This project looks at the Math Workshop Model as being one alternative to the more traditional teaching practices that are used today in the ABC School …


Contributions Of Semantic And Phonological Working Memory To Narrative Language Independent Of Single Word Production: Evidence From Acute Stroke, Rachel Zahn, Tatiana T Schnur, Randi C Martin Dec 2022

Contributions Of Semantic And Phonological Working Memory To Narrative Language Independent Of Single Word Production: Evidence From Acute Stroke, Rachel Zahn, Tatiana T Schnur, Randi C Martin

Faculty, Staff and Student Publications

Neuropsychological case studies have provided evidence that individuals with semantic, but not phonological, working memory (WM) deficits have difficulty producing phrases containing several content words. These findings supported the claim of a phrasal scope of planning at the grammatical formulation stage of production, where semantic WM supports the maintenance of lexical-semantic representations as they are inserted into slots in phrasal constituents. Recent narrative production results for individuals at the acute stage of stroke supported the role for semantic WM in phrasal elaboration while suggesting a role for phonological WM at a subsequent phonological encoding stage in supporting fluent, rapid speech. …


Trib3 Mediates Fibroblast Activation And Fibrosis Though Interaction With Atf4 In Ipf, Lan Wang, Wenyu Zhao, Cong Xia, Zhongzheng Li, Weiming Zhao, Kai Xu, Ningdan Wang, Hui Lian, Ivan O Rosas, Guoying Yu Dec 2022

Trib3 Mediates Fibroblast Activation And Fibrosis Though Interaction With Atf4 In Ipf, Lan Wang, Wenyu Zhao, Cong Xia, Zhongzheng Li, Weiming Zhao, Kai Xu, Ningdan Wang, Hui Lian, Ivan O Rosas, Guoying Yu

Faculty, Staff and Students Publications

Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease characterized by fibroblast activation, excessive deposition of extracellular matrix, and progressive scarring; the pathogenesis remains elusive. The present study explored the role of Tribbles pseudokinase 3 (TRIB3), a well-known stress and metabolic sensor, in IPF. TRIB3 is down-regulated in the lungs of IPF patients in comparison to control subjects. Deficiency of TRIB3 markedly inhibited A549 epithelial cells’ proliferation and migration, significantly reducing wound healing. Conversely, overexpression of TRIB3 promoted A549 cell proliferation and transmigration while it inhibited its apoptosis. Meanwhile, overexpressed TRIB3 inhibited fibroblast activation and decreased ECM …