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Methylprednisolone For Heart Surgery In Infants - A Randomized, Controlled Trial, Kevin D Hill, Prince J Kannankeril, Jeffrey P Jacobs, H Scott Baldwin, Marshall L Jacobs, Sean M O'Brien, David P Bichel, Eric M Graham, Brian Blasiole, Ashraf Resheidat, Adil S Husain, S Ram Kumar, Jerry L Kirchner, Dianne S Gallup, Joseph W Turek, Mark Bleiweis, Bret Mettler, Alexis Benscoter, Eric Wald, Tara Karamlou, Andrew H Van Bergen, David Overman, Pirooz Eghtesady, Ryan Butts, John S Kim, John P Scott, Brett R Anderson, Michael F Swartz, Patrick I Mcconnell, David F Vener, Jennifer S Li, Stress Network Investigators

Faculty, Staff and Students Publications

BACKGROUND: Although perioperative prophylactic glucocorticoids have been used for decades, whether they improve outcomes in infants after heart surgery with cardiopulmonary bypass is unknown.

METHODS: We conducted a multicenter, prospective, randomized, placebo-controlled, registry-based trial involving infants (age) undergoing heart surgery with cardiopulmonary bypass at 24 sites participating in the Society of Thoracic Surgeons Congenital Heart Surgery Database. Registry data were used in the evaluation of outcomes. The infants were randomly assigned to receive prophylactic methylprednisolone (30 mg per kilogram of body weight) or placebo, which was administered into the cardiopulmonary-bypass pump-priming fluid. The primary end point was a ranked composite …

An Elf4 Hypomorphic Variant Results In Nk Cell Deficiency, Sandra Andrea Salinas, Emily M Mace, Matilde I Conte, Chun Shik Park, Yu Li, Joshua I Rosario-Sepulveda, Sanjana Mahapatra, Emily K Moore, Evelyn R Hernandez, Ivan K Chinn, Abigail E Reed, Barclay J Lee, Alexander Frumovitz, Richard A Gibbs, Jennifer E Posey, Lisa R Forbes Satter, Akaluck Thatayatikom, Eric J Allenspach, Theodore G Wensel, James R Lupski, H Daniel Lacorazza, Jordan S Orange

Faculty, Staff and Students Publications

NK cell deficiencies (NKD) are a type of primary immune deficiency in which the major immunologic abnormality affects NK cell number, maturity, or function. Since NK cells contribute to immune defense against virally infected cells, patients with NKD experience higher susceptibility to chronic, recurrent, and fatal viral infections. An individual with recurrent viral infections and mild hypogammaglobulinemia was identified to have an X-linked damaging variant in the transcription factor gene ELF4. The variant does not decrease expression but disrupts ELF4 protein interactions and DNA binding, reducing transcriptional activation of target genes and selectively impairing ELF4 function. Corroborating previous murine models …

Whole Genome Sequencing Identifies Structural Variants Contributing To Hematologic Traits In The Nhlbi Topmed Program, Marsha M. Wheeler, Adrienne M. Stilp, Shuquan Rao, Bjarni V. Halldórsson, Doruk Beyter, Jia Wen, Anna V. Mihkaylova, Laura Almasy, John Blangero, Joanne E. Curran

School of Medicine Publications

Genome-wide association studies have identified thousands of single nucleotide variants and small indels that contribute to variation in hematologic traits. While structural variants are known to cause rare blood or hematopoietic disorders, the genome-wide contribution of structural variants to quantitative blood cell trait variation is unknown. Here we utilized whole genome sequencing data in ancestrally diverse participants of the NHLBI Trans Omics for Precision Medicine program (N = 50,675) to detect structural variants associated with hematologic traits. Using single variant tests, we assessed the association of common and rare structural variants with red cell-, white cell-, and platelet-related quantitative …

Minds And Hearts And Digital Data. Collaborative Learning With Jesuit Manuscripts & Databases, Elisa Frei

Jesuit Higher Education: A Journal

In a conversation with Emanuele Colombo, John O’Malley explained his historical method in eight points. In describing them, he noticed how “sources are mute” and how “to make them speak I must ask them questions”,[1] “the continuities are stronger and deeper than the discontinuities,”[2] and “if I really understand what is going on, I can explain it to an intelligent ten-year-old.”[3]This article aims at presenting the strategies and outcomes of a Public History project that involves on the one hand Jesuit sources of the early modern period, and on the other, non-professional historians who never studied …

Trying To Capture, Cautiously, The O'Malley Style, James F. Keenan Sj

Jesuit Higher Education: A Journal

John W. O’Malley, S.J., has proffered and used the concept of style so as to name something other than content that is needed in order to understand argument or research. In a way, style is to contemporary argument what rhetoric was to grammar. This essay attempts to capture what O’Malley means by style, but also, and more importantly seeks to describe or capture O’Malley’s own style. By employing the different formats that Jesuit Higher Education: A Journal offers, the essay tries to highlight the relevance and richness of style in communicating the self to the other. In a word, style …

The Contributions Of John O’Malley, Sj, To The Ongoing Reception Of Vatican Ii, Massimo Faggioli

Jesuit Higher Education: A Journal

The article analyzes the major contributions of John O’Malley, SJ, to the reception of the Second Vatican Council, especially thanks to his book What Happened at Vatican II (2008) but also in the context of his other books on the council of Trent (2013) and on Vatican I (2018). O’Malley’s contributions are particularly important in the context of what can be called a crisis of reception of Vatican II and of an ecclesial disruption. But it is relevant for Catholic theology and Catholic higher education because the current ecclesial and theological crisis has, among its causes, also a lack of …

The First Jesuits And The First Jesuit Universities, Paul Grendler

Jesuit Higher Education: A Journal

John W. O’Malley S. J. in The First Jesuits described well the basic principles of the Jesuit educational ministry that shapeed Jesuit schools and universities. He did not discuss what constituted a Jesuit university because that was not the purpose of the book. After assessing the major contributions that O’Malley made to define the principles of Jesuit education, this article will pick up where O’Malley left off by describing the first Jesuit universities. There was not a single model of a Jesuit university. Instead, the Jesuits taught in four kinds of universities: the all-Jesuit university, the civic-Jesuit collegiate university, the …

John O’Malley And Jesuit Education: A Journey Into Humanism, Cristiano Casalini, Alessandro Corsi

Jesuit Higher Education: A Journal

This article reflects upon the impact of the work of John W. O’Malley, S.J. (1927–2022), on the field of the history of Jesuit education. In The First Jesuits (1993), O’Malley provided an innovative approach to the subject that refuted some long-standing preconceptions about the way Jesuit schools and universities had originally developed. The approach that he took to to the topic throughout the 1990s and 2000s allowed him to identify two intertwined educational traditions at the heart of the Jesuit pedagogical model: the humanistic tradition of the Renaissance period, based on the Isocratic concept of pietas, and the scholastic …

Peter Maynard's Blazing Saddles, Jack Morton

The Woodward Review: A Creative and Critical Journal

No abstract provided.

Near Infrared Spectroscopy Is Not A Surrogate Of Venous Occlusion Plethysmography To Assess Microvascular Resting Blood Flow And Function, Manuel Gomez, Alvaro N. Gurovich, Samuel Montalvo

International Journal of Exercise Science

International Journal of Exercise Science 15(2): 1616-1626, 2022. Near-infrared spectroscopy (NIRS) is a non-invasive technique that measures tissue perfusion using red blood cells oxygen saturation and venous occlusion plethysmography (VOP) is the gold standard to assess microvascular blood flow and function. The purpose of this study was to determine if NIRS can surrogate the microvascular blood flow assessment after an ischemic challenge obtained via VOP. Twenty apparently healthy subjects (10 males and 10 females), aged 18 to 35 years, were recruited for this single session study. NIRS probes were placed 40mm apart along the epicondylar muscles on the right forearm …

Honoring Vets Through Flights, Sarah Moss

The Voice

No abstract provided.

Clear Communication Is Key, Says Physics Professor, Lydia Post

The Voice

No abstract provided.

How Will Football Be Played In Heaven?, Erik Hoekstra

The Voice

No abstract provided.

Criminal Law Policy In The Field Of Fishery Based On Indonesia’S International Obligation, Marimin Marimin, Lazarus Tri Setyawan, Rb Sularto

Indonesian Journal of International Law

The Indonesian Fisheries Law has determined criminal threats for perpetrators of illegal fishing in the ZEEI. In practice, there are differences in the application of imprisonment instead of fines for Indonesian citizens and foreign nationals who do illegal fishing. Such differences create injustice for Indonesian citizens. The results of the study indicate that criminal law policies in the field of fisheries need to be based on justice, in the sense of equality before the law. Foreign nationals who catch illegal fishing in the ZEEI are subject to imprisonment instead of a fine, while foreign nationals are not. Therefore, the Fisheries …

Understanding The Failure Of Police Reform In Nigeria: A Case For Legal History Through Literature, Olaoluwa Folasade Oni

LLM Theses

On the 21st of October 2020, the world woke to images and video clips of the bloodied, broken bodies of Nigerians shared across social and traditional media. The night before, young Nigerians protesting police brutality were met with a government-sanctioned, combined police and military onslaught; Nigerias decades-long struggle with police dysfunction was brought to a head with the massacre of its citizens at the Lekki toll gate on the evening of October 20, 2020. This work problematizes the cycle of attempts at, and ultimate failure of, police reform in Nigeria. I argue that the colonial nature of policing is retained …

Why The Courts Should Stop Philly Da Larry Krasner’S Impeachment Trial, Bruce Ledewitz

Newspaper Columns

Collected biweekly contributions to the Pennsylvania Capital-Star, a nonpartisan, nonprofit news site.

2022 Fall Engr333 Project Section A Final Report, Dat Cao, Sam Hoover, Sawyer Masselink, Ian Vanderkooi, Matthew Carlson, Jacob Heeres, Anthony Nykamp, Jacob Wyngarden, Nate Anderson, Anna Giboney, Gia Mien Le, Jonathan Washburn, Jess Camp, Aubree Peters, Alin Stoica, Drew Stoneburner, Claire Sheppard, Alayna Spiering, Reid Veneman, James Viel

ENGR 333

Calvin University has committed to being carbon neutral by 2057. This entails removing all the natural gas consumption for heating, converting to electrical heating options, and then making carbon free electricity. This project looked into four different options: air source heat pumps, ground source heat pumps, renewable natural gas, and the efficiency of current equipment. Each option was examined throughout the course of the semester to determine feasibility of each solution, and which ones would be best to implement. As a class, section A decided ground source heat pumps along with thermostatic valves and the implementation of double pane windows …

Effective Treatment Modalities, Recommendations, And Desired Outcomes For Adolescents With Co-Occurring Disorders, Madelynn J. Revord

Counselor Education Capstones

This Capstone Project analyzes and assesses recent research of different modalities of treatment for adolescents with co-occurring disorders. While conducting research on this topic, the common goal of effective treatment for adolescents with co-occurring disorders includes eliminating continued substance abuse, resolving conduct concerns, developing appropriate coping skills, correcting negative thoughts and/or behaviors, decreasing delinquency, and addressing reoccurring mental health symptoms. Multidimensional family therapy, cognitive behavioral therapy, motivational interviewing, group therapy, and individual therapy are compared to formulate effective clinical approaches for adolescents with co-occurring disorders. Adverse childhood experiences, risk and protective factors, suicidality, community involvement, parental education and early intervention, …

Chicanos' Negotiation Of Language And Culture With Standard English In Cache Valley, Ut, Vanessa Garcia Vazquez

Fall Student Research Symposium 2022

Gloria Anzaldúa theorized that the Chicano English, which she felt best depicted her identity, is seen by educators and American society as an "illegitimate, bastard language" (1987). The stereotypical view on various language variations and vernaculars has contributed to this idea that non-standard English is "illegitimate" or wrong. A Chicano's first language is essentially both English and Spanish. They typically begin speaking Spanish at the beginning of their lives and shortly after they begin to learn English at school. However, this new language is introduced before they can learn the first—which produces a mix of both languages and is commonly …

Before Daughters And Amplifying Ambiguous Loss In Poetry: How The Line Break Functions As An Effect, Madison Smith

English Creative Writing Theses

The line break is almost impossible to define by itself and more tangible to define as an effect that works with all aspects of language within a poem. Through analysis of the poetic line in both the works of others and my own poetry, I show how the line break as an effect works to amplify feelings of ambiguous loss within individual poems. Looking at how the line break functions in poems having to do with ambiguous loss accomplishes two things: it educates readers on the intricacies of loss and especially non-death losses, and it brings the line break to …

Suffolk Journal, Vol.86, No. 8, 12/7/2022, Suffolk Journal

Suffolk Journal

No abstract provided.

Homelessness Among Utah Women, Candice B. Pierucci, Emily S. Darowski, Susan R. Madsen

Marketing and Strategy Faculty Publications

In 2020, the United States Interagency Council on Homelessness reported that an estimated 3,131 Utah residents experienced homelessness on any given day.¹ And, according to data shared by the Office of Homeless Services under the Utah Department of Workforce Services,² 24,037 people accessed homelessness services in Utah sometime during 2021. Clearly, homelessness is a grave concern for many Utah women and families. As the Utah Women & Leadership Project seeks to strengthen the impact of all Utah girls and women, understanding homelessness for female residents is important. This research snapshot focuses on three key areas:

1. An overview of …

Carlos Erazo-Caballero V. Attorney General United States Of America

2022 Decisions

Agency

Ivey Mccray V. William Jones

2022 Decisions

USDC for the District of New Jersey

Usa V. Wheeler Zamichieli

2022 Decisions

USDC for the Eastern District of Pennsylvania

The Importance Of Teaching Personal Finance, Ryan Brewer

Honors College Theses

Personal finance is a foreign concept to many, yet it is an essential concept for all. This research project considers the impact of a personal finance course being taught in an organized, non-profit setting. A community church offers a finance course to their congregants on an annual basis that is designed to teach short- and long-term personal finance concepts to individuals and families to encourage adequate budgeting and investment practices. This specific project will evaluate the participants skillset and confidence in their financial goals before and after they are involved with the course. The data of study will be collected …

Pseudo-Embryology And Personhood: How Embryological Pseudoscience Helps Structure The American Abortion Debate, Scott F. Gilbert

Biology Faculty Works

There is a pseudo-embryology flourishing today, well nourished by popular science, religious ideologies, and the public media. Just as eugenics was a pseudoscience that influenced (and still influences) American popular culture and which was responsible for racist anti-immigration laws (such as the Immigration Restriction Act of 1924), pseudo-embryology is also influencing popular culture and legislation. This new pseudoscience promotes the belief that science supports current zygotic and fetal personhood movements as well as anti-abortion legislation. However, what often passes for science are actually ideological myths, often grounded in and supporting male superiority. Indeed, the first myth of pseudo-embryology is that …

Usa V. Hugo Reynosa

2022 Decisions

USDC for the Middle District of Pennsylvania

Pause And Possibility: Pre-Service Teachers’ Perspectives On Creative Writing Clubs, Stephanie Altier

Honors Projects

Creative writing clubs can enrich the lives of writers and facilitators. These clubs provide many opportunities to enrich their members’ academic, social, and personal development (Clifton, 2022; Siskel & Jacobs, 2011; Lawton, 2021). This project uses a focus-group study of five pre-service Integrated Language Arts teachers to explore the teachers' perspectives on advising creative writing clubs. Their insight informs a web-based teacher resource, Creative Writing Club Hub. Major findings are that participants harbor low self-efficacy towards creative writing and that the most effective method for encouraging them to advise these clubs may be to create a creative writing community …

Khanal Becomes First Uab Faculty To Receive Prestigious, National Career Development Award, Staff

Browse All News

No abstract provided.