Digital Commons Network^™

Rsv-Induced Actin Modulation: Contributes To Bronchial Wall Thickening; Does Not Induce Emt, And Is Cdc42-Assisted, Sattya Narayan Talukdar

Theses and Dissertations

RSV is a negative-sense, single-stranded RNA virus that infects our respiratory tract and can cause severe bronchiolitis and pneumonia worldwide. RSV bronchiolitis causes more fatalities in infants and newborns and leads to severe hospitalization and even death of children. The host-RSV interaction has yet to be explored properly to explain RSV bronchiolitis. This study aimed to elucidate the connection between the modulation of host actin cytoskeletal with viral pathogenesis, including bronchiolitis. As bronchial wall thickening is a common feature of bronchiolitis, the contribution of RSV-infected airway epithelium to bronchial wall thickening was evaluated. RSV infection in the healthy adult bronchial …

Multispectral Imaging For Microchip Electrophoresis Enables Point-Of-Care Newborn Hemoglobin Variant Screening, Ran An, Yuning Huang, Anne Rocheleau, Qiaochu Zhang, Yuncheng Man, Zoe Sekyonda, Amma Owusu-Ansah, Umut A. Gurkan

Faculty Scholarship

Hemoglobin (Hb) disorders affect nearly 7% of the world's population. Globally, around 400,000 babies are born annually with sickle cell disease (SCD), primarily in sub-Saharan Africa where morbidity and mortality rates are high. Screening, early diagnosis, and monitoring are not widely accessible due to technical challenges and cost. We hypothesized that multispectral imaging will allow sensitive hemoglobin variant identification in existing affordable paper-based Hb electrophoresis. To test this hypothesis, we developed the first integrated point-of-care multispectral Hb variant test: Gazelle-Multispectral. Here, we evaluated the accuracy of Gazelle-Multispectral for Hb variant newborn screening in 265 newborns with known hemoglobin variants including …

Multicriteria Study Of The Violation Of The Principle Of Innocence In Traffic Accidents, Eduardo Luciano Hernández Ramos, Carlos Gilberto Rosero Martinez, Janneth Ximena Iglesias Quintana, Alex Javier Peñafiel Palacio

Neutrosophic Sets and Systems

No abstract provided.

Using Landsat Satellite Imagery To Estimate Groundcover In The Grainbelt Of Western Australia, Justin Laycock, Nick Middleton, Karen Holmes

Resource management technical reports

Maintaining vegetative groundcover is an important component of sustainable agricultural systems and plays a critical function for soil and land conservation in Western Australia’s (WA) grainbelt (the south-west cropping region). This report describes how satellite imagery can be used to quantitatively and objectively estimate total vegetative groundcover, both in near real time and historically across large areas. We used the Landsat seasonal fractional groundcover products developed by the Joint Remote Sensing Research Program from the extensive archive of Landsat imagery. These products provide an estimate of the percentage of green vegetation, non-green vegetation and bare soil for each 30 m …

Intelligent Autonomous Inspections Using Deep Learning And Detection Markers, Alejandro Martinez Acosta

Open Access Theses & Dissertations

Inspection of industrial and scientific facilities is a crucial task that must be performed regularly. These inspections tasks ensure that the facilityâ??s structure is in safe operational conditions for humans. Furthermore,the safe operation of industrial machinery, is dependent on the conditions of the environment. For safety reasons, inspections for both structural integrity and equipment is often manually performed by operators or technicians. Naturally, this is often a tedious and laborious task. Additionally, buildings and structures frequently contain hard to reach or dangerous areas, which leads to the harm, injury or death of humans. Autonomous robotic systems offer an attractive solution …

Dangerous Alliances: Russia’S Strategic Inroads In Latin America, Douglas Farah, Marianne Richardson

INSS Strategic Perspectives

Russia’s strategic interests in Latin America center on establishing a multisector, persistent presence in the Western Hemisphere as a counterweight to U.S. and North Atlantic Treaty Organization (NATO) presence in the former Soviet Union and bordering states. The engagement focuses on aggressive implementation of what the West calls the doctrine of “hybrid warfare.” This approach fuses hard and soft power across multiple domains, recognizing the existence of a permanent state of confrontation with the West. This strategy undergirds the rationalization and operationalization of Russia’s invasion of Ukraine.

The Inevitable U.S. Return And The Future Of Great Power Competition In South Asia, Thomas F. Lynch

INSS Strategic Perspectives

More than a year after America’s painful Afghanistan withdrawal, the future of U.S. and Western security interests in South Asia no longer relates mainly to the terrorism threat from Salafi jihadism, which has receded and reoriented there to be most menacing toward Pakistan and China. Instead, American security interests now require the proper posture for long-term Great Power competition (GPC) with China. Such a posture in South Asia requires patient, persistent growth in the slowly maturing, overt strategic security partnership with India and a quiet regeneration of a transactional one with Pakistan.

By The Inch, It’S A Cinch: The Case For Go-Ing Slow In First-Year Legal Writing Courses, Patrick J. Long

Journal Articles

No abstract provided.

Full Issue: 14(5) 2022 - Special Issue: Foreign Interference In Higher Education

Journal of Comparative & International Higher Education

No abstract provided.

The Applicability Of Joint Source-Channel Coding Systems To Aeronautical Mobile Telemetry Data, Jesse Richmond

Theses and Dissertations

Broadcast spectrum restrictions require greater efficiency from wireless transmission systems, particularly in applications where sections of spectrum previously reserved for military purposes have been sold to private interests. A joint source-channel coding system, in tandem with smart data selection techniques, is proposed as a potential solution to this problem. The workings of this joint source-channel coding system are detailed, with particular attention given to the decoding process.

Building Software Compliant Multidimensional Datasets Through Programmatic Solutions, Jon Enoch Jones

Theses and Dissertations

Meteorological and other multidimensional, georeferenced data is used extensively in science and engineering. These datasets are produced, shared, and used by organizations all over the world. Conventions have been developed specifying the metadata and format of these datasets in an effort to standardize the data and make it compatible with current and future software and web services. By necessity, the conventions are complex and difficult to implement correctly, resulting in useful datasets that are unusable in many applications due to lack of compliance with the conventions. By programmatically assigning metadata and guiding the dataset creator through the dataset creation process, …

Annual Report, Fiscal Year 2021/2022, Tennessee. Department Of Safety & Homeland Security.

Annual Report

No abstract provided.

A Systematic Approach To Configuring Metamap For Optimal Performance, Xia Jing, Akash Indani, Nina Hubig, Hua Min, Yang Gong, James J Cimino, Dean F Sittig, Lior Rennert, David Robinson, Paul Biondich, Adam Wright, Christian Nøhr, Timothy Law, Arild Faxvaag, Ronald Gimbel

Faculty, Staff and Student Publications

BACKGROUND: MetaMap is a valuable tool for processing biomedical texts to identify concepts. Although MetaMap is highly configurative, configuration decisions are not straightforward.

OBJECTIVE: To develop a systematic, data-driven methodology for configuring MetaMap for optimal performance.

METHODS: MetaMap, the word2vec model, and the phrase model were used to build a pipeline. For unsupervised training, the phrase and word2vec models used abstracts related to clinical decision support as input. During testing, MetaMap was configured with the default option, one behavior option, and two behavior options. For each configuration, cosine and soft cosine similarity scores between identified entities and gold-standard terms were …

Identifying Missing Is-A Relations In Orphanet Rare Disease Ontology, Maryamsadat Mohtashamian, Rashmie Abeysinghe, Xubing Hao, Licong Cui

Faculty, Staff and Student Publications

The Orphanet Rare Disease Ontology (ORDO) provides a structured vocabulary encapsulating rare diseases. Downstream applications of ORDO depend on its accuracy to effectively perform their tasks. In this paper, we implement an automated quality assurance pipeline to identify missing is-a relations in ORDO. We first obtain lexical features from concept names. Then we generate related and unrelated feature sharing concept-pairs, where a feature sharing concept-pair can further generate derived term-pairs. If an unrelated and related feature sharing concept-pair generate the same derived term-pair, then we suggest a potential missing is-a relation between the unrelated feature sharing concept-pair. Applying this approach …

Structural Variants Drive Context-Dependent Oncogene Activation In Cancer, Zhichao Xu, Dong-Sung Lee, Sahaana Chandran, Victoria T Le, Rosalind Bump, Jean Yasis, Sofia Dallarda, Samantha Marcotte, Benjamin Clock, Nicholas Haghani, Chae Yun Cho, Kadir C Akdemir, Selene Tyndale, P Andrew Futreal, Graham Mcvicker, Geoffrey M Wahl, Jesse R Dixon

Faculty, Staff and Student Publications

Higher-order chromatin structure is important for the regulation of genes by distal regulatory sequences. Structural variants (SVs) that alter three-dimensional (3D) genome organization can lead to enhancer-promoter rewiring and human disease, particularly in the context of cancer3. However, only a small minority of SVs are associated with altered gene expression4,5, and it remains unclear why certain SVs lead to changes in distal gene expression and others do not. To address these questions, we used a combination of genomic profiling and genome engineering to identify sites of recurrent changes in 3D genome structure in cancer and determine the effects of specific …

Pan-Cancer Landscape Of Aid-Related Mutations, Composite Mutations, And Their Potential Role In The Ici Response, Isaias Hernández-Verdin, Kadir C Akdemir, Daniele Ramazzotti, Giulio Caravagna, Karim Labreche, Karima Mokhtari, Khê Hoang-Xuan, Matthieu Peyre, Franck Bielle, Mehdi Touat, Ahmed Idbaih, Alex Duval, Marc Sanson, Agustí Alentorn

Faculty, Staff and Student Publications

Activation-induced cytidine deaminase, AICDA or AID, is a driver of somatic hypermutation and class-switch recombination in immunoglobulins. In addition, this deaminase belonging to the APOBEC family may have off-target effects genome-wide, but its effects at pan-cancer level are not well elucidated. Here, we used different pan-cancer datasets, totaling more than 50,000 samples analyzed by whole-genome, whole-exome, or targeted sequencing. AID mutations are present at pan-cancer level with higher frequency in hematological cancers and higher presence at transcriptionally active TAD domains. AID synergizes initial hotspot mutations by a second composite mutation. AID mutational load was found to be independently associated with …

Germline Variants Associated With Toxicity To Immune Checkpoint Blockade, Stefan Groha, Sarah Abou Alaiwi, Wenxin Xu, Vivek Naranbhai, Amin H Nassar, Ziad Bakouny, Talal El Zarif, Renee Maria Saliby, Guihong Wan, Ahmad Rajeh, Elio Adib, Pier V Nuzzo, Andrew L Schmidt, Chris Labaki, Biagio Ricciuti, Joao Victor Alessi, David A Braun, Sachet A Shukla, Tanya E Keenan, Eliezer Van Allen, Mark M Awad, Michael Manos, Osama Rahma, Leyre Zubiri, Alexandra-Chloe Villani, Benjamin Fairfax, Christian Hammer, Zia Khan, Kerry Reynolds, Yevgeniy Semenov, Deborah Schrag, Kenneth L Kehl, Matthew L Freedman, Toni K Choueiri, Alexander Gusev

Faculty, Staff and Student Publications

Immune checkpoint inhibitors (ICIs) have yielded remarkable responses but often lead to immune-related adverse events (irAEs). Although germline causes for irAEs have been hypothesized, no individual variant associated with developing irAEs has been identified. We carried out a genome-wide association study of 1,751 patients on ICIs across 12 cancer types. We investigated two irAE phenotypes: (1) high-grade (3-5) and (2) all-grade events. We identified 3 genome-wide significant associations (P < 5 × 10-8) in the discovery cohort associated with all-grade irAEs: rs16906115 near IL7 (combined P = 3.6 × 10-11; hazard ratio (HR) = 2.1); rs75824728 near IL22RA1 (combined P = 3.5 × 10-8; HR = 1.8); and rs113861051 on 4p15 (combined P = 1.2 × 10-8, HR = 2.0); rs16906115 was replicated in 3 independent studies. The association near IL7 colocalized with the gain of a new cryptic exon for IL7, a critical regulator of lymphocyte homeostasis. Patients carrying the IL7 germline variant exhibited significantly increased lymphocyte stability after ICI initiation, which was itself predictive of downstream irAEs and improved survival.

Quantification Of Manipulation Forces Needed For Robot-Assisted Reduction Of The Ankle Syndesmosis: An Initial Cadaveric Study, Mikias Gebremeskel, Babar Shafiq, Ali Uneri, Niral Sheth, Corey Simmerer, Wojciech Zbijewski, Jeffrey H Siewerdsen, Kevin Cleary, Gang Li

Faculty, Staff and Student Publications

PURPOSE: Manual surgical manipulation of the tibia and fibula is necessary to properly align and reduce the space in ankle fractures involving sprain of the distal tibiofibular syndesmosis. However, manual reduction is highly variable and can result in malreduction in about half of the cases. Therefore, we are developing an image-guided robotic assistant to improve reduction accuracy. The purpose of this study is to quantify the forces associated with reduction of the ankle syndesmosis to define the requirements for our robot design.

METHODS: Using a cadaveric specimen, we designed a fixture jig to fix the tibia securely on the operating …

Mildly Dysplastic Oral Lesions With Optically-Detectable Abnormalities Share Genetic Similarities With Severely Dysplastic Lesions, David R Brenes, Allison J Nipper, Melody T Tan, Frederico O Gleber-Netto, Richard A Schwarz, Curtis R Pickering, Michelle D Williams, Nadarajah Vigneswaran, Ann M Gillenwater, Andrew G Sikora, Rebecca R Richards-Kortum

Faculty, Staff and Student Publications

OBJECTIVE: Optical imaging studies of oral premalignant lesions have shown that optical markers, including loss of autofluorescence and altered morphology of epithelial cell nuclei, are predictive of high-grade pathology. While these optical markers are consistently positive in lesions with moderate/severe dysplasia or cancer, they are positive only in a subset of lesions with mild dysplasia. This study compared the gene expression profiles of lesions with mild dysplasia (stratified by optical marker status) to lesions with severe dysplasia and without dysplasia.

MATERIALS AND METHODS: Forty oral lesions imaged in patients undergoing oral surgery were analyzed: nine without dysplasia, nine with severe …

Learning From The Past: A Century Of Accuracy, Aspirations, And Aspersions In Brachytherapy, Christopher S Melhus, Samantha J Simiele, Manik Aima, Susan Richardson

Faculty, Staff and Student Publications

The oldest form of radiation therapy, brachytherapy, has been investigated and reported in the scientific and medical literature for well over a century. Known by many names over the years, radium-based, empirical practices evolved over decades to contemporary practice. This includes treatment at various dose rates using multiple radionuclides or even electrically generated photon sources. Predictions or prognostications of what may happen in the future enjoy a history that spans centuries, e.g. those by Nostradamus in the 1500s. In this review article, publications from several eras of past practice between the early 1900s and the late 2010s where the authors …

Biobehavioral Factors Predict An Exosome Biomarker Of Ovarian Carcinoma Disease Progression, Susan K Lutgendorf, Premal H Thaker, Michael J Goodheart, Jesusa M G Arevalo, Mamur A Chowdhury, Alyssa E Noble, Laila Dahmoush, George M Slavich, Frank J Penedo, Anil K Sood, Steven W Cole

Faculty, Staff and Student Publications

BACKGROUND: Biobehavioral factors such as social isolation and depression have been associated with disease progression in ovarian and other cancers. Here, the authors developed a noninvasive, exosomal RNA profile for predicting ovarian cancer disease progression and subsequently tested whether it increased in association with biobehavioral risk factors.

METHODS: Exosomes were isolated from plasma samples from 100 women taken before primary surgical resection or neoadjuvant (NACT) treatment of ovarian carcinoma and 6 and 12 months later. Biobehavioral measures were sampled at all time points. Plasma from 76 patients was allocated to discovery analyses in which morning presurgical/NACT exosomal RNA profiles were …

Juvenile Report, December 2022, Tennessee. Department Of Correction.

Juvenile Reports

No abstract provided.

Tennessee Felon Population Update, December 2022, Tennessee. Department Of Correction.

Felon Population Reports

No abstract provided.

Tennessee Jail Summary Report, December 2022, Tennessee. Department Of Correction.

Jail Summary Reports

No abstract provided.

The Price Of Longevity - Empirical Evidence From Road Pavements, Hanna Kemaw

Lyles School of Civil Engineering Graduate Student Reports

The vast network of county, city and town roads, represent a big part of public assets in most states and often account for a significant share of the public spending on roads. This spending on local road infrastructure help to build, operate, and preserve such infrastructure and therefore provide critical accessibility and mobility to the residents of counties, towns and cities. With the ever-growing volumes of personal and commercial traffic at local roads, the task of maintaining satisfactory levels of service at local roads has become more challenging, and this issue is exacerbated by limited resources, asset aging, and increasing …

Identifying Dis/Misinformation On Social Media: A Policy Report For The Diplomacy Lab Strategies For Identifying Mis/Disinformation Project, Bethany S. Mcgowan, Matthew Hannah, Sofia Babcock, Katelyn Biggs, Lara Chuppe, Christina Galiatsatos, Jannine Huby, Michael Kuczajda, Bennet Miller, Stephanie Perun, Amanda Shie, Alicia Stevance, Andrew Yason, Charlotte Yeung

Libraries Faculty and Staff Scholarship and Research

Dis/misinformation was a major concern in the 2016 U.S. presidential election and has only worsened in recent years. Even though domestic actors often spread dis/misinformation, actors abroad can use it to spread confusion and push their agenda to the detriment of American citizens. Even though this report focuses on actors outside the United States, the methods they use are universal and can be adapted to work against domestic agents. A solid understanding of these methods is the first step in combating foreign dis/misinformation campaigns and creating a new information literacy paradigm.

This report highlights the primary mechanisms of dis/misinformation: multimedia …

A Jurisprudential Quilt Of Tribal Civil Jurisdiction: An Analysis Of Tribal Court Approaches To Determining Civil Adjudicatory Jurisdiction, Jacob Maiman-Stadtmauer

American Indian Law Journal

There are hundreds of Native American Tribes with their own judicial systems and courts. Under the test first established in Montana v. United States, the Supreme Court of the United States has provided a single, nebulous standard for determining the limits of tribal courts’ jurisdiction over non-Indians. Scholars and federal jurists have long assumed that the Supreme Court's framework limiting tribal civil jurisdiction is essential to how tribal courts determine jurisdiction. This paper challenges that assumption. Through a first of its kind survey of tribal court decisions on civil jurisdiction, spanning 26 tribes and covering 71 decisions, this paper …

The Digital Isolation Of Indigenous Communities, Myranda Buiquy

American Indian Law Journal

The crude mistreatment of the tribes across America has continued to undermine Indigenous wealth and empowerment, leaving many Native people without proper housing, education, running water, healthcare, and telecommunications services. Tribes are forced to advocate for themselves to the federal government, instead of receiving support and compensation for generations of colossal exploitation.The federal government continues to breach their responsibility in protecting tribal treaty rights and must assume responsibility in closing an economic divide that has only worsened due to the pandemic.

Indigenous communities continue to endure disadvantaged living conditions, leaving their people without adequate resources. In addition, this vulnerable demographic …

Education Administration In Federal Indian Law: Learning From A Colonial Project Turned Tool Of Liberation, Ariel Liberman, Douglas L. Waters Jr.

American Indian Law Journal

While statistics tend to focus on the difficulties facing tribal education, this article endeavors to look at the matter with fresh eyes. The federal administrative paradigm governing tribal schools has gone from a tool of cultural genocide to a mechanism for empowerment. A survey of recent governmental reforms demonstrates an embrace of the diversity of Indigenous communities, an interest in empowering students through learning, and an acknowledgement of a history of active disenfranchisement. This is ever-evolving federal-tribal relationship shows the administrative state’s capacity for dealing with greatly nuanced community needs and for tailor-making reforms to achieve concrete goals, even if …

Distinct Thalamic And Frontal Neuroanatomical Substrates In Children With Familial Vs. Non-Familial Attention-Deficit/Hyperactivity Disorder (Adhd), Rahman Baboli, Meng Cao, Jeffrey M. Halperin, Xiaobo Li

Publications and Research

Attention-deficit/hyperactivity disorder (ADHD) is a highly prevalent, inheritable, and heterogeneous neurodevelopmental disorder. Children with a family history of ADHD are at elevated risk of having ADHD and persisting its symptoms into adulthood. The objective of this study was to investigate the influence of having or not having positive family risk factor in the neuroanatomy of the brain in children with ADHD. Cortical thickness-, surface area-, and volume-based measures were extracted and compared in a total of 606 participants, including 132, 165, and 309 in groups of familial ADHD (ADHD-F), non-familial ADHD (ADHD-NF), and typically developed children, respectively. Compared to controls, …