Digital Commons Network^™

Stimulus Discrimination Training And Its Effects On Generalization Gradients, Christopher Veenstra

Theses and Dissertations

Adaptation-level theory has been used to explain how the size and shape of generalization gradients depend on the procedure used to study generalization. However, most of the empirical support for this theory has come from studies using a relatively simple stimulus dimension (e.g., lights that vary in brightness). In addition, much of the research has focused on one specific prediction of adaptation-level theory: that responding during a generalization test should shift towards intermediate values within the tested portion of the stimulus dimension. The present research used a more complex set of stimuli. Specifically, the stimulus dimension was based on bar …

Identifying Motivations Of New Counselors For Continuing Professional Development Of Multicultural Competencies: A Qualitative Study, Larry English

Dissertations

The need to increase multicultural counseling skills is a crucial area of focus in the continued evolution of the counseling profession. This necessity is due to a number of factors, including the ongoing demographic and societal changes in the United States. The research has helped to bring awareness of the need for increased and continued professional development in the area of cultural literacy and multicultural competencies skills for beginning counselors and others in counseling-related programs. At the micro level, the research investigated new clinicians’ self-awareness of their own biases, assumptions, internalized/externalized actions, and beliefs toward other cultures. The purpose of …

The Characterization Of Natural Ingredients As Pharmaceutical Excipients In Paracetamol Tablets, Nigel Patrick Brooks Jr

All Theses

Excipients used in pharmaceuticals are inactive ingredients that play a big role in drug formulations, and drug delivery systems. Binders are a type of pharmaceutical excipient that is crucial to the stability, physical characteristics, and cohesiveness of the tablet. Fully synthetic binders, such as polyethylene glycol (PEG), are commonly used due to their great formulation traits; however, these materials may have a slow dissolution rate, reduced bioavailability, or the potential to cause allergic reactions. Due to these limitations, natural excipients would be a great alternative due to their biocompatibility and faster dissolution rate. The purpose of this research was to …

A Fresh Look At A University Website: Redesigning The Graphic Communication Website, Kristy Leung, Samantha Kim

Graphic Communication

Designed over ten years ago, the landing page of the Graphic Communication website does not reflect the artistic talents of the department and exhibits poor navigation and usability. Colleen Twomey, the department chair, has expressed that prospective students, transfers, guardians, and other visitors have trouble finding relevant information on the website. As a university-affiliated site, the landing page should guide both new and returning visitors to their destination in a quick and intuitive manner. The primary goal of this project is to effectively educate new visitors who are interested in the Graphic Communication program but have minimal knowledge of what …

Cultivating Christian Community In A Post-Covid Era, Susie M. Lloyd

Journalism

This study focuses on how to meet the needs of young adult Christians through community and resources, all of which aim to help them live more like Jesus. There are many online resources for Christians, but society lacks a “one-stop shop” website that has every resource a young adult following Jesus could need. These resources include an online community where people can choose what mode of community they need, whether that be one-on-one discipleship or mentorship, consistent group meetings with people their own age, an accountability partner, or just a friend who shares similar beliefs and values. In an era …

Wordmuse, John M. Nelson

Computer Science and Software Engineering

Wordmuse is an application that allows users to enter a song and a list of keywords to create a new song. Built on Spotify's API, this project showcases the fusion of music composition and artificial intelligence. This paper also discusses the motivation, design, and creation of Wordmuse.

Novelty Ice Cream Assembly Prototype, Mason Sylvester, Logan Williamson, Alvaro Martinez, Adin Gilman-Cohen

Mechanical Engineering

Cool Beans USA is a novelty ice cream startup company founded by Keith Zachow. In the winter of 2022, our team began working with Mr. Zachow to develop a machine to automate parts of the production process for his product. This product consists of two hemispherical ice-cream cone shell halves filled with soft serve ice cream and pressed together. The assembled pods are around the size and shape of a small walnut and are intended to be sold in stores as a frozen finger food. At the time of project inception, this product was in its early stages and was …

Community In Culture: The Role Of Multicultural Education In Elementary School, Michaela Novack

Senior Honors Theses

Racism, bias, and discrimination plagues all areas of society, including the school systems. With the wrong perspective, diversity causes division, and it is impacting students, even in elementary schools. This thesis will examine research about the issue of racism and bias in elementary schools and suggest the solution of cultural integration experiences with practical strategies. It will demonstrate how cultural diversity in instruction encourages students to identify stereotypes, readjust their perspectives of culture, and identify and appreciate their cultural differences. This instruction can be achieved through a variety of methods including virtual field trips, diverse literature, and class activities. The …

Possible Role Of The Storm-Generated Streamwise Vorticity In Tornado Intensification And Evolution, Lance Reed Wilson

Theses and Dissertations

Streamwise vorticity developing within the forward flank (FF) of supercell thunderstorms has been found to modulate the intensity of the low-level mesocyclone. However, few studies have quantitatively investigated FF vorticity contributions to low-level mesocyclone intensity. This study investigates the relative contribution of streamwise vorticity within the FF to the low-level mesocyclone strength using two Cloud Model 1 simulations with 75 m horizontal grid spacing initialized with the 18Z Jackson, MS, special sounding from the environment that produced the 27 April 2011 Tuscaloosa tornado. Vorticity budgets were calculated along forward trajectories that enter the low-level mesocyclone. Trajectories traversing through the FF …

Rsv-Induced Actin Modulation: Contributes To Bronchial Wall Thickening; Does Not Induce Emt, And Is Cdc42-Assisted, Sattya Narayan Talukdar

Theses and Dissertations

RSV is a negative-sense, single-stranded RNA virus that infects our respiratory tract and can cause severe bronchiolitis and pneumonia worldwide. RSV bronchiolitis causes more fatalities in infants and newborns and leads to severe hospitalization and even death of children. The host-RSV interaction has yet to be explored properly to explain RSV bronchiolitis. This study aimed to elucidate the connection between the modulation of host actin cytoskeletal with viral pathogenesis, including bronchiolitis. As bronchial wall thickening is a common feature of bronchiolitis, the contribution of RSV-infected airway epithelium to bronchial wall thickening was evaluated. RSV infection in the healthy adult bronchial …

Multispectral Imaging For Microchip Electrophoresis Enables Point-Of-Care Newborn Hemoglobin Variant Screening, Ran An, Yuning Huang, Anne Rocheleau, Qiaochu Zhang, Yuncheng Man, Zoe Sekyonda, Amma Owusu-Ansah, Umut A. Gurkan

Faculty Scholarship

Hemoglobin (Hb) disorders affect nearly 7% of the world's population. Globally, around 400,000 babies are born annually with sickle cell disease (SCD), primarily in sub-Saharan Africa where morbidity and mortality rates are high. Screening, early diagnosis, and monitoring are not widely accessible due to technical challenges and cost. We hypothesized that multispectral imaging will allow sensitive hemoglobin variant identification in existing affordable paper-based Hb electrophoresis. To test this hypothesis, we developed the first integrated point-of-care multispectral Hb variant test: Gazelle-Multispectral. Here, we evaluated the accuracy of Gazelle-Multispectral for Hb variant newborn screening in 265 newborns with known hemoglobin variants including …

Multicriteria Study Of The Violation Of The Principle Of Innocence In Traffic Accidents, Eduardo Luciano Hernández Ramos, Carlos Gilberto Rosero Martinez, Janneth Ximena Iglesias Quintana, Alex Javier Peñafiel Palacio

Neutrosophic Sets and Systems

No abstract provided.

Using Landsat Satellite Imagery To Estimate Groundcover In The Grainbelt Of Western Australia, Justin Laycock, Nick Middleton, Karen Holmes

Resource management technical reports

Maintaining vegetative groundcover is an important component of sustainable agricultural systems and plays a critical function for soil and land conservation in Western Australia’s (WA) grainbelt (the south-west cropping region). This report describes how satellite imagery can be used to quantitatively and objectively estimate total vegetative groundcover, both in near real time and historically across large areas. We used the Landsat seasonal fractional groundcover products developed by the Joint Remote Sensing Research Program from the extensive archive of Landsat imagery. These products provide an estimate of the percentage of green vegetation, non-green vegetation and bare soil for each 30 m …

Intelligent Autonomous Inspections Using Deep Learning And Detection Markers, Alejandro Martinez Acosta

Open Access Theses & Dissertations

Inspection of industrial and scientific facilities is a crucial task that must be performed regularly. These inspections tasks ensure that the facilityâ??s structure is in safe operational conditions for humans. Furthermore,the safe operation of industrial machinery, is dependent on the conditions of the environment. For safety reasons, inspections for both structural integrity and equipment is often manually performed by operators or technicians. Naturally, this is often a tedious and laborious task. Additionally, buildings and structures frequently contain hard to reach or dangerous areas, which leads to the harm, injury or death of humans. Autonomous robotic systems offer an attractive solution …

Dangerous Alliances: Russia’S Strategic Inroads In Latin America, Douglas Farah, Marianne Richardson

INSS Strategic Perspectives

Russia’s strategic interests in Latin America center on establishing a multisector, persistent presence in the Western Hemisphere as a counterweight to U.S. and North Atlantic Treaty Organization (NATO) presence in the former Soviet Union and bordering states. The engagement focuses on aggressive implementation of what the West calls the doctrine of “hybrid warfare.” This approach fuses hard and soft power across multiple domains, recognizing the existence of a permanent state of confrontation with the West. This strategy undergirds the rationalization and operationalization of Russia’s invasion of Ukraine.

The Inevitable U.S. Return And The Future Of Great Power Competition In South Asia, Thomas F. Lynch

INSS Strategic Perspectives

More than a year after America’s painful Afghanistan withdrawal, the future of U.S. and Western security interests in South Asia no longer relates mainly to the terrorism threat from Salafi jihadism, which has receded and reoriented there to be most menacing toward Pakistan and China. Instead, American security interests now require the proper posture for long-term Great Power competition (GPC) with China. Such a posture in South Asia requires patient, persistent growth in the slowly maturing, overt strategic security partnership with India and a quiet regeneration of a transactional one with Pakistan.

By The Inch, It’S A Cinch: The Case For Go-Ing Slow In First-Year Legal Writing Courses, Patrick J. Long

Journal Articles

No abstract provided.

Full Issue: 14(5) 2022 - Special Issue: Foreign Interference In Higher Education

Journal of Comparative & International Higher Education

No abstract provided.

The Applicability Of Joint Source-Channel Coding Systems To Aeronautical Mobile Telemetry Data, Jesse Richmond

Theses and Dissertations

Broadcast spectrum restrictions require greater efficiency from wireless transmission systems, particularly in applications where sections of spectrum previously reserved for military purposes have been sold to private interests. A joint source-channel coding system, in tandem with smart data selection techniques, is proposed as a potential solution to this problem. The workings of this joint source-channel coding system are detailed, with particular attention given to the decoding process.

Building Software Compliant Multidimensional Datasets Through Programmatic Solutions, Jon Enoch Jones

Theses and Dissertations

Meteorological and other multidimensional, georeferenced data is used extensively in science and engineering. These datasets are produced, shared, and used by organizations all over the world. Conventions have been developed specifying the metadata and format of these datasets in an effort to standardize the data and make it compatible with current and future software and web services. By necessity, the conventions are complex and difficult to implement correctly, resulting in useful datasets that are unusable in many applications due to lack of compliance with the conventions. By programmatically assigning metadata and guiding the dataset creator through the dataset creation process, …

Annual Report, Fiscal Year 2021/2022, Tennessee. Department Of Safety & Homeland Security.

Annual Report

No abstract provided.

A Systematic Approach To Configuring Metamap For Optimal Performance, Xia Jing, Akash Indani, Nina Hubig, Hua Min, Yang Gong, James J Cimino, Dean F Sittig, Lior Rennert, David Robinson, Paul Biondich, Adam Wright, Christian Nøhr, Timothy Law, Arild Faxvaag, Ronald Gimbel

Faculty, Staff and Student Publications

BACKGROUND: MetaMap is a valuable tool for processing biomedical texts to identify concepts. Although MetaMap is highly configurative, configuration decisions are not straightforward.

OBJECTIVE: To develop a systematic, data-driven methodology for configuring MetaMap for optimal performance.

METHODS: MetaMap, the word2vec model, and the phrase model were used to build a pipeline. For unsupervised training, the phrase and word2vec models used abstracts related to clinical decision support as input. During testing, MetaMap was configured with the default option, one behavior option, and two behavior options. For each configuration, cosine and soft cosine similarity scores between identified entities and gold-standard terms were …

Identifying Missing Is-A Relations In Orphanet Rare Disease Ontology, Maryamsadat Mohtashamian, Rashmie Abeysinghe, Xubing Hao, Licong Cui

Faculty, Staff and Student Publications

The Orphanet Rare Disease Ontology (ORDO) provides a structured vocabulary encapsulating rare diseases. Downstream applications of ORDO depend on its accuracy to effectively perform their tasks. In this paper, we implement an automated quality assurance pipeline to identify missing is-a relations in ORDO. We first obtain lexical features from concept names. Then we generate related and unrelated feature sharing concept-pairs, where a feature sharing concept-pair can further generate derived term-pairs. If an unrelated and related feature sharing concept-pair generate the same derived term-pair, then we suggest a potential missing is-a relation between the unrelated feature sharing concept-pair. Applying this approach …

Structural Variants Drive Context-Dependent Oncogene Activation In Cancer, Zhichao Xu, Dong-Sung Lee, Sahaana Chandran, Victoria T Le, Rosalind Bump, Jean Yasis, Sofia Dallarda, Samantha Marcotte, Benjamin Clock, Nicholas Haghani, Chae Yun Cho, Kadir C Akdemir, Selene Tyndale, P Andrew Futreal, Graham Mcvicker, Geoffrey M Wahl, Jesse R Dixon

Faculty, Staff and Student Publications

Higher-order chromatin structure is important for the regulation of genes by distal regulatory sequences. Structural variants (SVs) that alter three-dimensional (3D) genome organization can lead to enhancer-promoter rewiring and human disease, particularly in the context of cancer3. However, only a small minority of SVs are associated with altered gene expression4,5, and it remains unclear why certain SVs lead to changes in distal gene expression and others do not. To address these questions, we used a combination of genomic profiling and genome engineering to identify sites of recurrent changes in 3D genome structure in cancer and determine the effects of specific …

Pan-Cancer Landscape Of Aid-Related Mutations, Composite Mutations, And Their Potential Role In The Ici Response, Isaias Hernández-Verdin, Kadir C Akdemir, Daniele Ramazzotti, Giulio Caravagna, Karim Labreche, Karima Mokhtari, Khê Hoang-Xuan, Matthieu Peyre, Franck Bielle, Mehdi Touat, Ahmed Idbaih, Alex Duval, Marc Sanson, Agustí Alentorn

Faculty, Staff and Student Publications

Activation-induced cytidine deaminase, AICDA or AID, is a driver of somatic hypermutation and class-switch recombination in immunoglobulins. In addition, this deaminase belonging to the APOBEC family may have off-target effects genome-wide, but its effects at pan-cancer level are not well elucidated. Here, we used different pan-cancer datasets, totaling more than 50,000 samples analyzed by whole-genome, whole-exome, or targeted sequencing. AID mutations are present at pan-cancer level with higher frequency in hematological cancers and higher presence at transcriptionally active TAD domains. AID synergizes initial hotspot mutations by a second composite mutation. AID mutational load was found to be independently associated with …

Germline Variants Associated With Toxicity To Immune Checkpoint Blockade, Stefan Groha, Sarah Abou Alaiwi, Wenxin Xu, Vivek Naranbhai, Amin H Nassar, Ziad Bakouny, Talal El Zarif, Renee Maria Saliby, Guihong Wan, Ahmad Rajeh, Elio Adib, Pier V Nuzzo, Andrew L Schmidt, Chris Labaki, Biagio Ricciuti, Joao Victor Alessi, David A Braun, Sachet A Shukla, Tanya E Keenan, Eliezer Van Allen, Mark M Awad, Michael Manos, Osama Rahma, Leyre Zubiri, Alexandra-Chloe Villani, Benjamin Fairfax, Christian Hammer, Zia Khan, Kerry Reynolds, Yevgeniy Semenov, Deborah Schrag, Kenneth L Kehl, Matthew L Freedman, Toni K Choueiri, Alexander Gusev

Faculty, Staff and Student Publications

Immune checkpoint inhibitors (ICIs) have yielded remarkable responses but often lead to immune-related adverse events (irAEs). Although germline causes for irAEs have been hypothesized, no individual variant associated with developing irAEs has been identified. We carried out a genome-wide association study of 1,751 patients on ICIs across 12 cancer types. We investigated two irAE phenotypes: (1) high-grade (3-5) and (2) all-grade events. We identified 3 genome-wide significant associations (P < 5 × 10-8) in the discovery cohort associated with all-grade irAEs: rs16906115 near IL7 (combined P = 3.6 × 10-11; hazard ratio (HR) = 2.1); rs75824728 near IL22RA1 (combined P = 3.5 × 10-8; HR = 1.8); and rs113861051 on 4p15 (combined P = 1.2 × 10-8, HR = 2.0); rs16906115 was replicated in 3 independent studies. The association near IL7 colocalized with the gain of a new cryptic exon for IL7, a critical regulator of lymphocyte homeostasis. Patients carrying the IL7 germline variant exhibited significantly increased lymphocyte stability after ICI initiation, which was itself predictive of downstream irAEs and improved survival.

Quantification Of Manipulation Forces Needed For Robot-Assisted Reduction Of The Ankle Syndesmosis: An Initial Cadaveric Study, Mikias Gebremeskel, Babar Shafiq, Ali Uneri, Niral Sheth, Corey Simmerer, Wojciech Zbijewski, Jeffrey H Siewerdsen, Kevin Cleary, Gang Li

Faculty, Staff and Student Publications

PURPOSE: Manual surgical manipulation of the tibia and fibula is necessary to properly align and reduce the space in ankle fractures involving sprain of the distal tibiofibular syndesmosis. However, manual reduction is highly variable and can result in malreduction in about half of the cases. Therefore, we are developing an image-guided robotic assistant to improve reduction accuracy. The purpose of this study is to quantify the forces associated with reduction of the ankle syndesmosis to define the requirements for our robot design.

METHODS: Using a cadaveric specimen, we designed a fixture jig to fix the tibia securely on the operating …

Mildly Dysplastic Oral Lesions With Optically-Detectable Abnormalities Share Genetic Similarities With Severely Dysplastic Lesions, David R Brenes, Allison J Nipper, Melody T Tan, Frederico O Gleber-Netto, Richard A Schwarz, Curtis R Pickering, Michelle D Williams, Nadarajah Vigneswaran, Ann M Gillenwater, Andrew G Sikora, Rebecca R Richards-Kortum

Faculty, Staff and Student Publications

OBJECTIVE: Optical imaging studies of oral premalignant lesions have shown that optical markers, including loss of autofluorescence and altered morphology of epithelial cell nuclei, are predictive of high-grade pathology. While these optical markers are consistently positive in lesions with moderate/severe dysplasia or cancer, they are positive only in a subset of lesions with mild dysplasia. This study compared the gene expression profiles of lesions with mild dysplasia (stratified by optical marker status) to lesions with severe dysplasia and without dysplasia.

MATERIALS AND METHODS: Forty oral lesions imaged in patients undergoing oral surgery were analyzed: nine without dysplasia, nine with severe …

Learning From The Past: A Century Of Accuracy, Aspirations, And Aspersions In Brachytherapy, Christopher S Melhus, Samantha J Simiele, Manik Aima, Susan Richardson

Faculty, Staff and Student Publications

The oldest form of radiation therapy, brachytherapy, has been investigated and reported in the scientific and medical literature for well over a century. Known by many names over the years, radium-based, empirical practices evolved over decades to contemporary practice. This includes treatment at various dose rates using multiple radionuclides or even electrically generated photon sources. Predictions or prognostications of what may happen in the future enjoy a history that spans centuries, e.g. those by Nostradamus in the 1500s. In this review article, publications from several eras of past practice between the early 1900s and the late 2010s where the authors …

Biobehavioral Factors Predict An Exosome Biomarker Of Ovarian Carcinoma Disease Progression, Susan K Lutgendorf, Premal H Thaker, Michael J Goodheart, Jesusa M G Arevalo, Mamur A Chowdhury, Alyssa E Noble, Laila Dahmoush, George M Slavich, Frank J Penedo, Anil K Sood, Steven W Cole

Faculty, Staff and Student Publications

BACKGROUND: Biobehavioral factors such as social isolation and depression have been associated with disease progression in ovarian and other cancers. Here, the authors developed a noninvasive, exosomal RNA profile for predicting ovarian cancer disease progression and subsequently tested whether it increased in association with biobehavioral risk factors.

METHODS: Exosomes were isolated from plasma samples from 100 women taken before primary surgical resection or neoadjuvant (NACT) treatment of ovarian carcinoma and 6 and 12 months later. Biobehavioral measures were sampled at all time points. Plasma from 76 patients was allocated to discovery analyses in which morning presurgical/NACT exosomal RNA profiles were …