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Articles 152401 - 152430 of 1326676

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Interview With Jason Brown, Utah State University Special Collections & Archives Dec 2022

Interview With Jason Brown, Utah State University Special Collections & Archives

Utah State University COVID-19 Oral History Collection

No abstract provided.

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Drug Abuse Ontology To Harness Web-Based Data For Substance Use Epidemiology Research, Usha Lokala, Francois Lamy, Raminta Daniulaityte, Manas Gaur, Amelie Gyrard, Krishnaprasad Thirunarayan, Ugur Kursuncu, Amit Sheth Dec 2022

Drug Abuse Ontology To Harness Web-Based Data For Substance Use Epidemiology Research, Usha Lokala, Francois Lamy, Raminta Daniulaityte, Manas Gaur, Amelie Gyrard, Krishnaprasad Thirunarayan, Ugur Kursuncu, Amit Sheth

Computer Science and Engineering Faculty Publications

Background: Web-based resources and social media platforms play an increasingly important role in health-related knowledge and experience sharing. There is a growing interest in the use of these novel data sources for epidemiological surveillance of substance use behaviors and trends. Objective: The key aims were to describe the development and application of the drug abuse ontology (DAO) as a framework for analyzing web-based and social media data to inform public health and substance use research in the following areas: determining user knowledge, attitudes, and behaviors related to nonmedical use of buprenorphine and illicitly manufactured opioids through the analysis of web …

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Getting It Wrong: Applying Public Security Limitation To The East African Community's Right Of Establishment In Kenya, Priscah Wamucii Nyotah, Francis D.P. Situma, Edwin Abuya Dec 2022

Getting It Wrong: Applying Public Security Limitation To The East African Community's Right Of Establishment In Kenya, Priscah Wamucii Nyotah, Francis D.P. Situma, Edwin Abuya

The Transnational Human Rights Review

The Right of Establishment (ROE) is one of the rights and freedoms provided for under the East African Community’s Common Market Protocol. Under this right, citizens of East African Community Partner States, namely, Kenya, Uganda, Tanzania, Rwanda, Burundi, South Sudan, and the Democratic Republic of Congo are entitled to move to any other Partner State and pursue economic activities, as self-employed persons. Their spouses and children are also entitled to this right or to be employed. They are also entitled to join the security schemes of the host PS. However, the right is not absolute. A PS can limit the …

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Federalism And Constitutional Hyper-Rigidity: A Comparative Analysis Of The Federalist Amendment Mechanisms Within The Australian And United States Constitutions, Amy Buckley Dec 2022

Federalism And Constitutional Hyper-Rigidity: A Comparative Analysis Of The Federalist Amendment Mechanisms Within The Australian And United States Constitutions, Amy Buckley

The Transnational Human Rights Review

The amendment mechanisms contained within the Australian and United States Constitutions, being Section 128 and Article V respectively, have many structural similarities. Both amendment mechanisms are purposed towards protecting federalism insofar as they require the achievement of more than just a simple constituent majority before a referendum proposal will succeed. In fact, the entrenchment of the Australian and United States ‘double’ and ‘super’ majority requirements respectively were specifically included as a protection for the federal distribution of power originally mandated within the Constitutions of each. Building upon that framework, if the Australian and American constitutional amendment mechanisms are purposed towards …

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December 1, 2022, Caa Dec 2022

December 1, 2022, Caa

Minutes

No abstract provided.

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A Predictive Model Using The Mesoscopic Architecture Of The Living Brain To Detect Alzheimer’S Disease, Marianna Inglese, Neva Patel, Kristofer Linton-Reid, Flavia Loreto, Zarni Win, Richard J. Perry, Christopher Carswell, Matthew Grech-Sollars, William R. Crum, Haonan Lu, Paresh A. Malhotra, Lisa C. Silbert, Betty Lind, Rachel Crissey, Jeffrey A. Kaye, Raina Carter, Sara Dolen, Joseph Quinn, Lon S. Schneider, Sonia Pawluczyk, Mauricio Becerra, Liberty Teodoro, Karen Dagerman, Bryan M. Spann, James Brewer, Helen Vanderswag, Adam Fleisher, Jaimie Ziolkowski, Judith L. Heidebrink, Zbizek-Nulph, Joanne L. Lord, Lisa Zbizek-Nulph, Ronald Petersen, Sara S. Mason Dec 2022

A Predictive Model Using The Mesoscopic Architecture Of The Living Brain To Detect Alzheimer’S Disease, Marianna Inglese, Neva Patel, Kristofer Linton-Reid, Flavia Loreto, Zarni Win, Richard J. Perry, Christopher Carswell, Matthew Grech-Sollars, William R. Crum, Haonan Lu, Paresh A. Malhotra, Lisa C. Silbert, Betty Lind, Rachel Crissey, Jeffrey A. Kaye, Raina Carter, Sara Dolen, Joseph Quinn, Lon S. Schneider, Sonia Pawluczyk, Mauricio Becerra, Liberty Teodoro, Karen Dagerman, Bryan M. Spann, James Brewer, Helen Vanderswag, Adam Fleisher, Jaimie Ziolkowski, Judith L. Heidebrink, Zbizek-Nulph, Joanne L. Lord, Lisa Zbizek-Nulph, Ronald Petersen, Sara S. Mason

Clinical Research Faculty Publications

Background: Alzheimer’s disease, the most common cause of dementia, causes a progressive and irreversible deterioration of cognition that can sometimes be difficult to diagnose, leading to suboptimal patient care. Methods: We developed a predictive model that computes multi-regional statistical morpho-functional mesoscopic traits from T1-weighted MRI scans, with or without cognitive scores. For each patient, a biomarker called “Alzheimer’s Predictive Vector” (ApV) was derived using a two-stage least absolute shrinkage and selection operator (LASSO). Results: The ApV reliably discriminates between people with (ADrp) and without (nADrp) Alzheimer’s related pathologies (98% and 81% accuracy between ADrp - including the early form, mild …

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The Polygenic Risk Score Knowledge Base Offers A Centralized Online Repository For Calculating And Contextualizing Polygenic Risk Scores, Madeline L. Page, Elizabeth L. Vance, Matthew E. Cloward, Ed Ringger, Louisa Dayton, Mark T.W. Ebbert, L. Ravdin, M. Lin, A. Lee, G. Chiang, N. Relkin, R. B. Santulli, M. L. Hynes, M. Seltzer, L. A. Flashman, K. Anderson, K. Blank, G. D. Perlson, S. Kittur, S. Correia, P. Malloy, S. Salloway, S. Potkin, P. Newhouse, M. Sabbagh, A. Garcia, J. Shi, J. Masdeu, A. Williams, J. Mintzer, A. O’Connell, A. Mintz, D. Munic, C. Bernick Dec 2022

The Polygenic Risk Score Knowledge Base Offers A Centralized Online Repository For Calculating And Contextualizing Polygenic Risk Scores, Madeline L. Page, Elizabeth L. Vance, Matthew E. Cloward, Ed Ringger, Louisa Dayton, Mark T.W. Ebbert, L. Ravdin, M. Lin, A. Lee, G. Chiang, N. Relkin, R. B. Santulli, M. L. Hynes, M. Seltzer, L. A. Flashman, K. Anderson, K. Blank, G. D. Perlson, S. Kittur, S. Correia, P. Malloy, S. Salloway, S. Potkin, P. Newhouse, M. Sabbagh, A. Garcia, J. Shi, J. Masdeu, A. Williams, J. Mintzer, A. O’Connell, A. Mintz, D. Munic, C. Bernick

Clinical Research Faculty Publications

The process of identifying suitable genome-wide association (GWA) studies and formatting the data to calculate multiple polygenic risk scores on a single genome can be laborious. Here, we present a centralized polygenic risk score calculator currently containing over 250,000 genetic variant associations from the NHGRI-EBI GWAS Catalog for users to easily calculate sample-specific polygenic risk scores with comparable results to other available tools. Polygenic risk scores are calculated either online through the Polygenic Risk Score Knowledge Base (PRSKB; https://prs.byu.edu) or via a command-line interface. We report study-specific polygenic risk scores across the UK Biobank, 1000 Genomes, and the Alzheimer’s Disease …

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Total Energy Expenditure Is Repeatable In Adults But Not Associated With Short-Term Changes In Body Composition, Rebecca Rimbach, Yosuke Yamada, Hiroyuki Sagayama, Philip N. Ainslie, Lene F. Anderson, Liam J. Anderson, Lenore Arab, Issaad Baddou, Kweku Bedu-Addo, Ellen E. Blaak, Stephane Blanc, Alberto G. Bonomi, Carlijn V.C. Bouten, Pascal Bovet, Maciej S. Buchowski, Nancy F. Butte, Stefan G.J.A. Camps, Graeme L. Close, Jamie A. Cooper, Sai Krupa Das, Lara R. Dugas, Ulf Ekelund, Sonja Entringer, Terrence Forrester, Barry W. Fudge, Annelies H. Goris, Michael Gurven, Catherine Hambly, Asmaa El Hamdouchi, Marije B. Hoos, Sumei Hu, Noorjehan Joonas, Annemiek M. Joosen, Peter Katzmarzyk Dec 2022

Total Energy Expenditure Is Repeatable In Adults But Not Associated With Short-Term Changes In Body Composition, Rebecca Rimbach, Yosuke Yamada, Hiroyuki Sagayama, Philip N. Ainslie, Lene F. Anderson, Liam J. Anderson, Lenore Arab, Issaad Baddou, Kweku Bedu-Addo, Ellen E. Blaak, Stephane Blanc, Alberto G. Bonomi, Carlijn V.C. Bouten, Pascal Bovet, Maciej S. Buchowski, Nancy F. Butte, Stefan G.J.A. Camps, Graeme L. Close, Jamie A. Cooper, Sai Krupa Das, Lara R. Dugas, Ulf Ekelund, Sonja Entringer, Terrence Forrester, Barry W. Fudge, Annelies H. Goris, Michael Gurven, Catherine Hambly, Asmaa El Hamdouchi, Marije B. Hoos, Sumei Hu, Noorjehan Joonas, Annemiek M. Joosen, Peter Katzmarzyk

Clinical Research Faculty Publications

Low total energy expenditure (TEE, MJ/d) has been a hypothesized risk factor for weight gain, but repeatability of TEE, a critical variable in longitudinal studies of energy balance, is understudied. We examine repeated doubly labeled water (DLW) measurements of TEE in 348 adults and 47 children from the IAEA DLW Database (mean ± SD time interval: 1.9 ± 2.9 y) to assess repeatability of TEE, and to examine if TEE adjusted for age, sex, fat-free mass, and fat mass is associated with changes in weight or body composition. Here, we report that repeatability of TEE is high for adults, but …

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Low Total Osteocalcin Levels Are Associated With All-Cause And Cardiovascular Mortality Among Patients With Type 2 Diabetes: A Real-World Study, Yun Shen, Lei Chen, Jian Zhou, Chunfang Wang, Fei Gao, Wei Zhu, Gang Hu, Xiaojing Ma, Han Xia, Yuqian Bao Dec 2022

Low Total Osteocalcin Levels Are Associated With All-Cause And Cardiovascular Mortality Among Patients With Type 2 Diabetes: A Real-World Study, Yun Shen, Lei Chen, Jian Zhou, Chunfang Wang, Fei Gao, Wei Zhu, Gang Hu, Xiaojing Ma, Han Xia, Yuqian Bao

Population and Public Health Science Faculty Publications

Background: The association between osteocalcin and mortality has been scantly studied. We aimed to investigate the association between osteocalcin along with its trajectories and mortality based on long-term longitudinal data. Methods: We performed a retrospective cohort study of 9413 type 2 diabetic patients with at least three measurements of total serum osteocalcin within 3 years since their first inpatient diagnosis of type 2 diabetes. Baseline, mean values of osteocalcin levels and their trajectories were used as exposures. A multivariable-adjusted Cox proportional hazards model was used to estimate the association of osteocalcin levels and their trajectories with mortality. Results: During a …

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Safety Matters, Lehigh Valley Health Network Dec 2022

Safety Matters, Lehigh Valley Health Network

LVHN documents

No abstract provided.

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Needs-Based Standards Of Practice For The Use Of Forensic Genetic Genealogy In Investigations Of Violence Toward Marginalized Victims, Anthony Redgrave Dec 2022

Needs-Based Standards Of Practice For The Use Of Forensic Genetic Genealogy In Investigations Of Violence Toward Marginalized Victims, Anthony Redgrave

Doctor of Education Program Dissertations

The purpose of this qualitative narrative study was to identify strategies by which forensic genetic genealogy can be applied to cases of unidentified decedents who are from marginalized populations. Three research questions guided this study: (1) What is each affected group most concerned about regarding the use of forensic genetic genealogy to identify marginalized unidentified decedents or perpetrators of violent crime against marginalized group members?, (2) How have the past experiences of individuals in the affected groups contributed to their stance on the use of forensic genetic genealogy?, And (3) How do stakeholders’ opinions on the use of forensic genetic …

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Higher Education Professional Involved In Or Aspiring To Careers In Strategic Enrollment Management: Competency Development And Career Pathways, Jodi Ward Dec 2022

Higher Education Professional Involved In Or Aspiring To Careers In Strategic Enrollment Management: Competency Development And Career Pathways, Jodi Ward

Dissertations

Strategic Enrollment Management (SEM) is an emergent and evolving field in higher education (HE). While the concept has often been researched as a system or process implemented by an institution of HE to optimize enrollment, this study examined the professionals that currently lead or aspire to lead those systems. The HE competencies areas that current SEM professionals are most engaged with, the activities they participate in to gain and cultivate competency development, as well as their educational backgrounds and career pathways was the focus of this study. Additionally, this study investigated the competency development opportunities available to individuals working in …

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The Evaluation Of A Clinical Decision Support Tool Using Natural Language Processing To Screen Hospitalized Adults For Unhealthy Substance Use: Protocol For A Quasi-Experimental Design, Cara Joyce, Talar W. Markossian, Jenna Nikolaides, Elisabeth Ramsey, Hale M. Thompson, Juan C. Rojas, Brihat Sharma, Dmitriy Dligach, Madeline K. Oguss, Richard S. Cooper, Majid Afshar Dec 2022

The Evaluation Of A Clinical Decision Support Tool Using Natural Language Processing To Screen Hospitalized Adults For Unhealthy Substance Use: Protocol For A Quasi-Experimental Design, Cara Joyce, Talar W. Markossian, Jenna Nikolaides, Elisabeth Ramsey, Hale M. Thompson, Juan C. Rojas, Brihat Sharma, Dmitriy Dligach, Madeline K. Oguss, Richard S. Cooper, Majid Afshar

Faculty Publications

Background: Automated and data-driven methods for screening using natural language processing (NLP) and machine learning may replace resource-intensive manual approaches in the usual care of patients hospitalized with conditions related to unhealthy substance use. The rigorous evaluation of tools that use artificial intelligence (AI) is necessary to demonstrate effectiveness before system-wide implementation. An NLP tool to use routinely collected data in the electronic health record was previously validated for diagnostic accuracy in a retrospective study for screening unhealthy substance use. Our next step is a noninferiority design incorporated into a research protocol for clinical implementation with prospective evaluation of clinical …

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Leadership Development And Training In Community-Based Organizations In Myanmar, Anna Rockett Dec 2022

Leadership Development And Training In Community-Based Organizations In Myanmar, Anna Rockett

Honors Capstones

No abstract provided.

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Louisiana Children's Trust Fund Annual Report 2021-2022, Elizabeth Winchester, Jada Thomas-Smith, Harleen Sandhu, Aimee H. Moles, Judith L. F. Rhodes Dec 2022

Louisiana Children's Trust Fund Annual Report 2021-2022, Elizabeth Winchester, Jada Thomas-Smith, Harleen Sandhu, Aimee H. Moles, Judith L. F. Rhodes

Reports

Child abuse and neglect is a leading factor in the staggeringly high rates of child mortality in Louisiana. In 2017, Louisiana had 44,793 total referrals for child abuse and neglect of which 19,851 were investigated (CWLA, 2019). Child abuse and neglect can have multiple detrimental effects on a child’s physical, psychological, and behavioral health. Effective prevention efforts are critical to ensuring the immediate and long-term safety and well-being of children in Louisiana. Each year, LCTF selects high-quality proposals and funds a range of prevention efforts to protect children, strengthen family well-being, and educate the public about children’s safety. Local, national, …

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Channel Bed Adjustment Of The Lowermost Yangtze River Estuary From 1983 To 2018: Causes And Implications, Ming Tang, Heqin Cheng, Yijun Xu, Hao Hu, Shuwei Zheng, Bo Wang, Zhongyong Yang, Lizhi Teng, Wei Xu, Erfeng Zhang, Jiufa Li Dec 2022

Channel Bed Adjustment Of The Lowermost Yangtze River Estuary From 1983 To 2018: Causes And Implications, Ming Tang, Heqin Cheng, Yijun Xu, Hao Hu, Shuwei Zheng, Bo Wang, Zhongyong Yang, Lizhi Teng, Wei Xu, Erfeng Zhang, Jiufa Li

Faculty Publications

Deltaic channels are significant landforms at the interface of sediment transfer from land to oceanic realms. Understanding the dynamics of these channels is urgent because delta processes are sensitive to climate change and adjustments in human activity. To obtain a better understanding of the morphological processes of large deltaic channels, this study assessed the evolution and response mechanism of the South Channel and South Passage (SCSP) in the Yangtze Estuary between 1983 to 2018 using hydrology, multibeam echo sounding and historical bathymetry datasets. Decadal changes in riverbed volume and erosion/deposition patterns in the SCSP were assessed. The results showed that …

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Satisfaction Of Patients With Diabetic Kidney Disease With Traditional Chinese Medicine Physician Visits, Wanling Zeng, Hong Chang Tan, Huang Fang Zheng, Amanda Rui Lin Lam, Kok Keong Teo, Chieh Suai Tan, Jean Paul Kovalik, Sujoy Ghosh, Xiao Hui Xin Dec 2022

Satisfaction Of Patients With Diabetic Kidney Disease With Traditional Chinese Medicine Physician Visits, Wanling Zeng, Hong Chang Tan, Huang Fang Zheng, Amanda Rui Lin Lam, Kok Keong Teo, Chieh Suai Tan, Jean Paul Kovalik, Sujoy Ghosh, Xiao Hui Xin

Division of Basic Science Faculty Publications

Background: Patient-centred care is an important part of quality healthcare and patient satisfaction has been shown to be associated with improved clinical outcomes. We aim to explore the satisfaction of patients with diabetic kidney disease (DKD) with their visits to the TCM physician and its association with patients' socio-economic characteristics. Methods: A questionnaire survey was conducted among patients aged >21 years with DKD. Participants' demographic, socioeconomic characteristics and satisfaction scores measured with the self-administered Medical Interview Satisfaction Scale (MISS) were collected after they visited the TCM physician. MISS is a 26-item questionnaire consisting of three domains – cognitive, affective and …

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Interindividual Differences In Trainability And Moderators Of Cardiorespiratory Fitness, Waist Circumference, And Body Mass Responses: A Large-Scale Individual Participant Data Meta-Analysis, Jacob T. Bonafiglia, Paul A. Swinton, Robert Ross, Neil M. Johannsen, Corby K. Martin, Timothy S. Church, Cris A. Slentz, Leanna M. Ross, William E. Kraus, Jeremy J. Walsh, Glen P. Kenny, Gary S. Goldfield, Denis Prud’Homme, Ronald J. Sigal, Conrad P. Earnest, Brendon J. Gurd Dec 2022

Interindividual Differences In Trainability And Moderators Of Cardiorespiratory Fitness, Waist Circumference, And Body Mass Responses: A Large-Scale Individual Participant Data Meta-Analysis, Jacob T. Bonafiglia, Paul A. Swinton, Robert Ross, Neil M. Johannsen, Corby K. Martin, Timothy S. Church, Cris A. Slentz, Leanna M. Ross, William E. Kraus, Jeremy J. Walsh, Glen P. Kenny, Gary S. Goldfield, Denis Prud’Homme, Ronald J. Sigal, Conrad P. Earnest, Brendon J. Gurd

Clinical Research Faculty Publications

Although many studies have assumed variability reflects variance caused by exercise training, few studies have examined whether interindividual differences in trainability are present following exercise training. The present individual participant data (IPD) meta-analysis sought to: (1) investigate the presence of interindividual differences in trainability for cardiorespiratory fitness (CRF), waist circumference, and body mass; and (2) examine the influence of exercise training and potential moderators on the probability that an individual will experience clinically important differences. The IPD meta-analysis combined data from 1879 participants from eight previously published randomized controlled trials. We implemented a Bayesian framework to: (1) test the hypothesis …

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Study In Parkinson’S Disease Of Exercise Phase 3 (Sparx3): Study Protocol For A Randomized Controlled Trial, Charity G. Patterson, Elizabeth Joslin, Alexandra B. Gil, Wendy Spigle, Todd Nemet, Lana Chahine, Cory L. Christiansen, Ed Melanson, Wendy M. Kohrt, Martina Mancini, Deborah Josbeno, Katherine Balfany, Garett Griffith, Mac Kenzie Dunlap, Guillaume Lamotte, Erin Suttman, Danielle Larson, Chantale Branson, Kathleen E. Mckee, Li Goelz, Cynthia Poon, Barbara Tilley, Un Jung Kang, Malú Gámez Tansey, Nijee Luthra, Caroline M. Tanner, Jacob M. Haus, Giamila Fantuzzi, Nikolaus R. Mcfarland, Paulina Gonzalez-Latapi, Tatiana Foroud, Robert Motl, Michael A. Schwarzschild, Tanya Simuni Dec 2022

Study In Parkinson’S Disease Of Exercise Phase 3 (Sparx3): Study Protocol For A Randomized Controlled Trial, Charity G. Patterson, Elizabeth Joslin, Alexandra B. Gil, Wendy Spigle, Todd Nemet, Lana Chahine, Cory L. Christiansen, Ed Melanson, Wendy M. Kohrt, Martina Mancini, Deborah Josbeno, Katherine Balfany, Garett Griffith, Mac Kenzie Dunlap, Guillaume Lamotte, Erin Suttman, Danielle Larson, Chantale Branson, Kathleen E. Mckee, Li Goelz, Cynthia Poon, Barbara Tilley, Un Jung Kang, Malú Gámez Tansey, Nijee Luthra, Caroline M. Tanner, Jacob M. Haus, Giamila Fantuzzi, Nikolaus R. Mcfarland, Paulina Gonzalez-Latapi, Tatiana Foroud, Robert Motl, Michael A. Schwarzschild, Tanya Simuni

Clinical Research Faculty Publications

Background: To date, no medication has slowed the progression of Parkinson’s disease (PD). Preclinical, epidemiological, and experimental data on humans all support many benefits of endurance exercise among persons with PD. The key question is whether there is a definitive additional benefit of exercising at high intensity, in terms of slowing disease progression, beyond the well-documented benefit of endurance training on a treadmill for fitness, gait, and functional mobility. This study will determine the efficacy of high-intensity endurance exercise as first-line therapy for persons diagnosed with PD within 3 years, and untreated with symptomatic therapy at baseline. Methods: This is …

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Author Correction: Novel Mode Of Defective Neural Tube Closure In The Non-Obese Diabetic (Nod) Mouse Strain (Scientific Reports, (2015), 5, 1, (16917), 10.1038/Srep16917), J. Michael Salbaum, Claudia Kruger, Jacalyn Macgowan, Nils J. Herion, David Burk, Claudia Kappen Dec 2022

Author Correction: Novel Mode Of Defective Neural Tube Closure In The Non-Obese Diabetic (Nod) Mouse Strain (Scientific Reports, (2015), 5, 1, (16917), 10.1038/Srep16917), J. Michael Salbaum, Claudia Kruger, Jacalyn Macgowan, Nils J. Herion, David Burk, Claudia Kappen

Division of Basic Science Faculty Publications

The Supplementary Information file published with this Article is incomplete, where the supplementary figures and tables are omitted. The correct Supplementary Information file is now linked to this correction notice.

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Predicting Energy Intake In Adults Who Are Dieting And Exercising, Corey Gerving, Robert Lasater, James Starling, Danielle M. Ostendorf, Leanne M. Redman, Chad Estabrooks, Kevin Cummiskey, Vincent Antonetti, Diana M. Thomas Dec 2022

Predicting Energy Intake In Adults Who Are Dieting And Exercising, Corey Gerving, Robert Lasater, James Starling, Danielle M. Ostendorf, Leanne M. Redman, Chad Estabrooks, Kevin Cummiskey, Vincent Antonetti, Diana M. Thomas

Clinical Research Faculty Publications

Background: When a lifestyle intervention combines caloric restriction and increased physical activity energy expenditure (PAEE), there are two components of energy balance, energy intake (EI) and physical activity energy expenditure (PAEE), that are routinely misreported and expensive to measure. Energy balance models have successfully predicted EI if PAEE is known. Estimating EI from an energy balance model when PAEE is not known remains an open question. Objective: The objective was to evaluate the performance of an energy balance differential equation model to predict EI in an intervention that includes both calorie restriction and increases in PAEE. Design: The Antonetti energy …

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The Trend Of Disruption In The Functional Brain Network Topology Of Alzheimer’S Disease, Alireza Fathian, Yousef Jamali, Mohammad Reza Raoufy, Michael W. Weiner, Norbert Schuf, Howard J. Rosen, Bruce L. Miller, Thomas Neylan, Jacqueline Hayes, Shannon Finley, Paul Aisen, Zaven Khachaturian, Ronald G. Thomas, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Leon Thal, James Brewer, Helen Vanderswag, Adam Fleisher, Melissa Davis, Rosemary Morrison, Ronald Petersen, Cliford R. Jack, Matthew Bernstein, Bret Borowski, Jef Gunter, Matt Senjem, Prashanthi Vemuri, David Jones, Kejal Kantarci, Chad Ward Dec 2022

The Trend Of Disruption In The Functional Brain Network Topology Of Alzheimer’S Disease, Alireza Fathian, Yousef Jamali, Mohammad Reza Raoufy, Michael W. Weiner, Norbert Schuf, Howard J. Rosen, Bruce L. Miller, Thomas Neylan, Jacqueline Hayes, Shannon Finley, Paul Aisen, Zaven Khachaturian, Ronald G. Thomas, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Leon Thal, James Brewer, Helen Vanderswag, Adam Fleisher, Melissa Davis, Rosemary Morrison, Ronald Petersen, Cliford R. Jack, Matthew Bernstein, Bret Borowski, Jef Gunter, Matt Senjem, Prashanthi Vemuri, David Jones, Kejal Kantarci, Chad Ward

Clinical Research Faculty Publications

Alzheimer’s disease (AD) is a progressive disorder associated with cognitive dysfunction that alters the brain’s functional connectivity. Assessing these alterations has become a topic of increasing interest. However, a few studies have examined different stages of AD from a complex network perspective that cover different topological scales. This study used resting state fMRI data to analyze the trend of functional connectivity alterations from a cognitively normal (CN) state through early and late mild cognitive impairment (EMCI and LMCI) and to Alzheimer’s disease. The analyses had been done at the local (hubs and activated links and areas), meso (clustering, assortativity, and …

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Dissociation Of Tau Pathology And Neuronal Hypometabolism Within The Atn Framework Of Alzheimer’S Disease, Michael Tran Duong, Sandhitsu R. Das, Xueying Lyu, Long Xie, Hayley Richardson, Sharon X. Xie, Paul A. Yushkevich, Michael Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John C. Morris, Leslie M. Shaw, Enchi Liu, Tom Montine, Ronald G. Thomas, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gustavo Jimenez-Maggiora, Danielle Harvey, Matthew Bernstein, Nick Fox, Paul Thompson, Norbert Schuff, Charles Decarli, Bret Borowski Dec 2022

Dissociation Of Tau Pathology And Neuronal Hypometabolism Within The Atn Framework Of Alzheimer’S Disease, Michael Tran Duong, Sandhitsu R. Das, Xueying Lyu, Long Xie, Hayley Richardson, Sharon X. Xie, Paul A. Yushkevich, Michael Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John C. Morris, Leslie M. Shaw, Enchi Liu, Tom Montine, Ronald G. Thomas, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gustavo Jimenez-Maggiora, Danielle Harvey, Matthew Bernstein, Nick Fox, Paul Thompson, Norbert Schuff, Charles Decarli, Bret Borowski

Clinical Research Faculty Publications

Alzheimer’s disease (AD) is defined by amyloid (A) and tau (T) pathologies, with T better correlated to neurodegeneration (N). However, T and N have complex regional relationships in part related to non-AD factors that influence N. With machine learning, we assessed heterogeneity in 18F-flortaucipir vs. 18F-fluorodeoxyglucose positron emission tomography as markers of T and neuronal hypometabolism (NM) in 289 symptomatic patients from the Alzheimer’s Disease Neuroimaging Initiative. We identified six T/NM clusters with differing limbic and cortical patterns. The canonical group was defined as the T/NM pattern with lowest regression residuals. Groups resilient to T had less hypometabolism than expected …

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Author Correction: Fam222a Encodes A Protein Which Accumulates In Plaques In Alzheimer’S Disease (Nature Communications, (2020), 11, 1, (411), 10.1038/S41467-019-13962-0), Tingxiang Yan, Jingjing Liang, Ju Gao, Luwen Wang, Hisashi Fujioka, Michael W. Weiner, Norbert Schuff, Howard J. Rosen, Bruce L. Miller, David Perry, Paul Aisen, Paul Aisen, Arthur W. Toga, Gustavo Jimenez, Michael Donohue, Devon Gessert, Kelly Harless, Jennifer Salazar, Yuliana Cabrera, Sarah Walter, Lindsey Hergesheimer, Karen Crawford, Scott Neu, Lon S. Schneider, Sonia Pawluczyk, Mauricio Becerra, Liberty Teodoro, Bryan M. Spann, Ronald Petersen, Clifford R. Jack, Matthew Bernstein, Bret Borowski, Jeff Gunter, Matt Senjem Dec 2022

Author Correction: Fam222a Encodes A Protein Which Accumulates In Plaques In Alzheimer’S Disease (Nature Communications, (2020), 11, 1, (411), 10.1038/S41467-019-13962-0), Tingxiang Yan, Jingjing Liang, Ju Gao, Luwen Wang, Hisashi Fujioka, Michael W. Weiner, Norbert Schuff, Howard J. Rosen, Bruce L. Miller, David Perry, Paul Aisen, Paul Aisen, Arthur W. Toga, Gustavo Jimenez, Michael Donohue, Devon Gessert, Kelly Harless, Jennifer Salazar, Yuliana Cabrera, Sarah Walter, Lindsey Hergesheimer, Karen Crawford, Scott Neu, Lon S. Schneider, Sonia Pawluczyk, Mauricio Becerra, Liberty Teodoro, Bryan M. Spann, Ronald Petersen, Clifford R. Jack, Matthew Bernstein, Bret Borowski, Jeff Gunter, Matt Senjem

Clinical Research Faculty Publications

In the original version of the manuscript, the image shown in Figure 4g, bottom row (Aβ1–42 + rAggregatin), under “6h” was incorrect. This image incorrectly showed the same sample as shown in the original Figure 4g, top row (Aβ1–42), under “0.5h”. The correct version of figure 4g is as follows: (Figure presented.) which replaces the previous incorrect version: (Figure presented.).

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Uterine Lumen Fluid Is Metabolically Semi-Autonomous, Constantine A. Simintiras, Jessica N. Drum, Hongyu Liu, M. Sofia Ortega, Thomas E. Spencer Dec 2022

Uterine Lumen Fluid Is Metabolically Semi-Autonomous, Constantine A. Simintiras, Jessica N. Drum, Hongyu Liu, M. Sofia Ortega, Thomas E. Spencer

Faculty Publications

Uterine lumen fluid (ULF) is central to successful pregnancy establishment and maintenance, and impacts offspring wellbeing into adulthood. The current dogma is that ULF composition is primarily governed by endometrial glandular epithelial cell secretions and influenced by progesterone. To investigate the hypothesis that ULF is metabolically semi-autonomous, ULF was obtained from cyclic heifers, and aliquots incubated for various durations prior to analysis by untargeted semi-quantitative metabolomic profiling. Metabolite flux was observed in these ULF isolates, supporting the idea that the biochemical makeup of ULF is semi-autonomously dynamic due to enzyme activities. Subsequent integrative analyses of these, and existing, data predict …

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Non-Destructive Quality Evaluation Of Tropical Fruit (Mango And Mangosteen) Purée Using Near-Infrared Spectroscopy Combined With Partial Least Squares Regression, Pimpen Pornchaloempong, Sneha Sharma, Thitima Phanomsophon, Kraisuwit Srisawat, Wasan Inta, Panmanas Sirisomboon, Witoon Prinyawiwatkul, Natrapee Nakawajana, Ravipat Lapcharoensuk, Sontisuk Teerachaichayut Dec 2022

Non-Destructive Quality Evaluation Of Tropical Fruit (Mango And Mangosteen) Purée Using Near-Infrared Spectroscopy Combined With Partial Least Squares Regression, Pimpen Pornchaloempong, Sneha Sharma, Thitima Phanomsophon, Kraisuwit Srisawat, Wasan Inta, Panmanas Sirisomboon, Witoon Prinyawiwatkul, Natrapee Nakawajana, Ravipat Lapcharoensuk, Sontisuk Teerachaichayut

Faculty Publications

Mango and mangosteen are commercially important tropical fruits with a short shelf life. Fruit processing is one of the alternatives to extend the shelf life of these fruits. Purée is one of the processed products of fresh fruit. In this research, the quality of mango and mangosteen purée was analyzed. Titratable acidity (TA) and total soluble solids (TSS) were predicted using non-destructive near-infrared (NIR) spectroscopy. A partial least squares regression (PLSR) model was developed based on the NIR spectra with a wavelength ranging from 800 to 2500 nm. The PLSR model returned a coefficient of determination (r2) and a ratio …

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Smart Quantum Statistical Imaging Beyond The Abbe-Rayleigh Criterion, Narayan Bhusal, Mingyuan Hong, Ashe Miller, Mario A. Quiroz-Juárez, Roberto De J. León-Montiel, Chenglong You, Omar S. Magaña-Loaiza Dec 2022

Smart Quantum Statistical Imaging Beyond The Abbe-Rayleigh Criterion, Narayan Bhusal, Mingyuan Hong, Ashe Miller, Mario A. Quiroz-Juárez, Roberto De J. León-Montiel, Chenglong You, Omar S. Magaña-Loaiza

Faculty Publications

The wave nature of light imposes limits on the resolution of optical imaging systems. For over a century, the Abbe-Rayleigh criterion has been utilized to assess the spatial resolution limits of imaging instruments. Recently, there has been interest in using spatial projective measurements to enhance the resolution of imaging systems. Unfortunately, these schemes require a priori information regarding the coherence properties of “unknown” light beams and impose stringent alignment conditions. Here, we introduce a smart quantum camera for superresolving imaging that exploits the self-learning features of artificial intelligence to identify the statistical fluctuations of unknown mixtures of light sources at …

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Health Physics Workforce In The United States, Michael A. Noska, Caridad Borrás, E. Vincent Holahan, Shaheen A. Dewji, Thomas E. Johnson, Jerry W. Hiatt, Wayne D. Newhauser, John W. Poston, Nolan Hertel Dec 2022

Health Physics Workforce In The United States, Michael A. Noska, Caridad Borrás, E. Vincent Holahan, Shaheen A. Dewji, Thomas E. Johnson, Jerry W. Hiatt, Wayne D. Newhauser, John W. Poston, Nolan Hertel

Faculty Publications

No abstract provided.

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Medical Physics Workforce In The United States, Wayne D. Newhauser, Dustin A. Gress, Michael D. Mills, David W. Jordan, Steven G. Sutlief, Melissa C. Martin, Edward Jackson Dec 2022

Medical Physics Workforce In The United States, Wayne D. Newhauser, Dustin A. Gress, Michael D. Mills, David W. Jordan, Steven G. Sutlief, Melissa C. Martin, Edward Jackson

Faculty Publications

No abstract provided.

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Detecting Quantum Critical Points Of Correlated Systems By Quantum Convolutional Neural Network Using Data From Variational Quantum Eigensolver, Nathaniel Wrobel, Anshumitra Baul, Ka Ming Tam, Juana Moreno Dec 2022

Detecting Quantum Critical Points Of Correlated Systems By Quantum Convolutional Neural Network Using Data From Variational Quantum Eigensolver, Nathaniel Wrobel, Anshumitra Baul, Ka Ming Tam, Juana Moreno

Faculty Publications

Machine learning has been applied to a wide variety of models, from classical statistical mechanics to quantum strongly correlated systems, for classifying phase transitions. The recently proposed quantum convolutional neural network (QCNN) provides a new framework for using quantum circuits instead of classical neural networks as the backbone of classification methods. We present the results from training the QCNN by the wavefunctions of the variational quantum eigensolver for the one-dimensional transverse field Ising model (TFIM). We demonstrate that the QCNN identifies wavefunctions corresponding to the paramagnetic and ferromagnetic phases of the TFIM with reasonable accuracy. The QCNN can be trained …

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