Digital Commons Network^™

Loss Of Pex1 In Inner Ear Hair Cells Contributes To Cochlear Synaptopathy And Hearing Loss., Stephanie A Mauriac, Thibault Peineau, Aamir Zuberi, Cathleen Lutz, Gwénaëlle S G Géléoc

Faculty Research 2022

Peroxisome Biogenesis Disorders (PBD) and Zellweger syndrome spectrum disorders (ZSD) are rare genetic multisystem disorders that include hearing impairment and are associated with defects in peroxisome assembly, function, or both. Mutations in 13 peroxin (PEX) genes have been found to cause PBD-ZSD with ~70% of patients harboring mutations in PEX1. Limited research has focused on the impact of peroxisomal disorders on auditory function. As sensory hair cells are particularly vulnerable to metabolic changes, we hypothesize that mutations in PEX1 lead to oxidative stress affecting hair cells of the inner ear, subsequently resulting in hair cell degeneration and hearing loss. Global …

Usa V. William Boney

2022 Decisions

USDC for the District of Delaware

Same As It Ever Was: An Exploration And Demonstration Of Techniques For Repurposing And Modernizing Advanced Musical Vocabulary In Mainstream Commercial Music, Aidan Scrivens

Composition/Recording Projects

In the market for tertiary level commercial music education, educators find themselves pulled between students' commercial stylistic interests and the seemingly incommensurable genres better suited to exploring advanced theoretical concepts and vocabulary. This divide can lead to a motivational deficiency in a student that, in turn, can hinder their development and render their collegiate experience less worth the expense. In the interest of combating this potential motivational deficiency, this recording project and accompanying paper explores and demonstrates the process of modernizing and recontextualizing material found in these less commercially mainstream genres. By adapting vocabulary and approaches learned from the transcription …

Is Teaching Experience A Predictor For School Psychologists' Confidence And Competence In Behavior Intervention Plans?, Misty Dawn Lainé Coplan

Theses and Dissertations

The Individuals with Disabilities Education Improvement Act (IDEIA) introduced Behavior Intervention Plans (BIPs) into United States law in 1990, and the reauthorization of IDEIA occurred in 2004. Even though BIPs have been codified into law, school personnel struggle to meet BIP mandates due to poor implementation fidelity. Barriers for BIP implementation are varied, but there is little research regarding whether practitioner competence and confidence through teaching experience is a factor. School psychologists (N = 122) from eight states completed a self-evaluation survey using the tailored design method. Results from the survey compared responses from school psychologists with and without teaching …

Creation Of Preschool Evaluation For Children Experiencing Sensory Processing Disorders, Brittney Tuck

Honors Theses

For our thesis project, we partnered with Dr. Michelle Suarez, the co-director of the Resiliency Center at Western Michigan University. When we first met with her, she informed us about the high rates of expulsion for Kalamazoo preschool students with various regulation challenges relating to sensory processing disorders, regulation, autism, and trauma. In fact, according to the U.S. Department of Health and Human Services, preschool students are expelled at three times the rate of children in K-12 (2022). Additionally, according to the Equal Justice Society, 250 preschool children get suspended or expelled each day nationwide (2021). The article continues to …

Effect Of Education On Self-Reported Health, Mai Le '24

Student Research

Human Capital Theory pointed out health as a possible return to education. The question at the center of this research is if education can improve health. Replicating the work of Goesling (2007) on new data from the 2000-2022 Current Population Survey (CPS), a cross-sectional probit analysis shows a positive relationship between educational level and self-reported health. This relationship is robust and significant across age groups.

Book Review Of Advanced Introduction To Legal Reasoning, Brian H. Bix

Journal of Legal Education

No abstract provided.

Abortion Pill Reversal And The Inappropriate Censorship Of Google Advertisements, Chloe S. Edwards

Pepperdine Policy Review

Abortion has been a contentious policy issue for nearly as long as United States has existed. From its legalization under the U.S. Constitution’s right to privacy in the Supreme Court decision of Roe v. Wade to the overturn of the decision this year in Dobbs v. Jackson Women’s Healthcare Organization, abortion policy has been on a back and forth swing for generations. The addition of medically advanced forms of abortion, including medical abortions administered via pills, has added another dimension to this already complicated matter. Recent censorship of abortion pill reversal ads by the internet site Google has shown the …

Exploring The Use Of Piox System For Treatment Of Endocrine Disrupting Compounds, Alexander Pearson

Civil Engineering Theses

In this thesis, the Photon Initiated Oxidation (PIOx) system was investigated for its possible use in the treatment of Endocrine Disrupting Compounds (EDCs). It was theorized that the unique design of the system, namely the multiple wavelengths of UV light and the micronfoam would improve removal rates of the test contaminant when compared to other systems. 17β-estradiol was chosen as the test contaminant due to the compounds known sensitivity to ozone exposure. Two methods of testing were used, the first to test an idealized homogenous concentration (method one) and the second to mimic the sudden influx of contaminant that would …

Intertribal Band, Lydia Wolfe

Undergraduate Research Symposium Podium Presentations

Research Journey: Class Project (1) Read article by Ed Johnson - school band traveling world in early 1900s (2) What happened to the band after this tour? Not much documentation was found on early school band years (3) Oftentimes extracurricular activities are overlooked in research (4) Looking deeper can sometimes lead to bigger revelations of the student body

Unpacking Athletics: An Exploration Of Identity Development For Division I Women College Athletes, Kathleen E. Scanlon

Dissertations - ALL

This dissertation explored how former Division I National Collegiate Athletic Association (NCAA) women athletes made meaning of their undergraduate experience and how it influenced their post-graduate lives. The study research questions focused on three areas: a) how participants constructed meaning from their athletic experiences and what role those experiences had in shaping their identity; b) how the participants made sense of the various systems they experienced and what bearing various identities had on their meaning making; and c) what concrete knowledge, skills and qualities participants felt they possessed today that they attribute to their intercollegiate athletic experiences.

Three semi-structured interviews …

Board Of Trustees Meeting Minutes, December 9, 2022

Board of Trustees Minutes

Minutes from the Wright State University Board of Trustees Meeting held on December 9, 2022.

The Dark Side Of Due Process: Part Iii, How To Use Irreverent Double-Talk To Speak Back To Bad Men, Joshua J. Schroeder

St. Mary's Law Journal

Most American lawyers take for granted that the common law established almost all the ordinary causes of action we know today. As Joseph Story’s Commentaries acknowledged, the common law is the basis of the entire U.S. system of law. Common law struggled with feudal and canon forms and eventually transformed them for the benefit of ordinary people even in the face of the most heinous travesties of the English and American past.

The Witch Judges of Salem, Massachusetts and the Parliament of Saints in England did not prevail through despotic radicalism to demolish the common law through codification. Legal positivism …

Distinctive Sans Forgetica Font Does Not Benefit Memory Accuracy In The Drm Paradigm, Mark J. Huff, Nicholas P. Maxwell, Anie Mitchell

Faculty Publications

A common method used by memory scholars to enhance retention is to make materials more challenging to learn—a benefit termed desirable difficulties. Recently, researchers have investigated the efficacy of Sans Forgetica, a perceptually disfluent/distinctive font which may increase processing effort required at study and enhance memory as a result. We examined the effects of Sans Forgetica relative to a standard control font (Arial) on both correct memory and associative memory errors using the Deese/Roediger–McDermott (DRM) false memory paradigm, to evaluate Sans Forgetica effects on overall memory accuracy. Across four experiments, which included nearly 300 participants, Sans Forgetica was found to …

From B2b Survivor To Sap’S Swallow: Sap Ariba’S Success, John Wang, Steve Bin Zhou, Yang Li, Houda El Bouhissi

Department of Information Management and Business Analytics Faculty Scholarship and Creative Works

Ariba Inc. and Commerce One Inc. (C1), two bellwethers with e-entrepreneurship in the e-commerce field, provided business-to-business (B2B) spend management and supply chain services. After having been wiped out by the devaluation of the stock market that followed the dot-com era, C1 is extinct today. Having faced the same market condition and serious competition, innovative Ariba had a different path and was acquired by SAP in 2012. Nowadays, SAP Ariba (formerly known as Ariba) is the largest digital B2B network on the planet. Why did Ariba survive whereas C1 collapsed? The authors explore the external (hidden costs, high-priced software, hurtful …

Pharmacotherapy For Opioid Use Disorder In Mississippi, Amanda Michelle Whitacre

Doctoral Projects

The opioid epidemic is affecting Mississippi’s young to middle-aged adult population in a profound way. Pharmacotherapy for opioid use disorder (OUD) is the gold standard treatment. Despite the FDA-approved evidence-based treatment of pharmacotherapy for OUD, rural areas often lack providers available who will initiate and provide maintenance of this life-saving medication. For this doctoral project, a 36-question survey was developed based on a preliminary literature review. The survey was disseminated to advanced practice registered nurses (APRNs) in the family and psychiatric specialties across Mississippi to assess the barriers to APRNs filling the gap in pharmacotherapy prescribing for OUD. A continuing …

Exploring The Acute Cardiovascular Effects Of Floatation-Rest., M C Flux, Thomas H. Fine, Tate Poplin, Obada Al Zoubi, William A. Schoenhals, Jesse Schettler, Hazem H. Refai, Jessyca Naegele, Colleen Wohlrab, Hung-Wen Yeh, Christopher A. Lowry, Jason C. Levine, Ryan Smith, Sahib S. Khalsa, Justin S. Feinstein

Manuscripts, Articles, Book Chapters and Other Papers

The central nervous system (CNS) exerts a strong regulatory influence over the cardiovascular system in response to environmental demands. Floatation-REST (Reduced Environmental Stimulation Therapy) is an intervention that minimizes stimulation from the environment, yet little is known about the autonomic consequences of reducing external sensory input to the CNS. We recently found that Floatation-REST induces a strong anxiolytic effect in anxious patients while paradoxically enhancing their interoceptive awareness for cardiorespiratory sensations. To further investigate the physiologic nature of this anxiolytic effect, the present study measured acute cardiovascular changes during Floatation-REST using wireless and waterproof equipment that allowed for concurrent measurement …

Determinism V. Free Will & Genetic Evidence Of Addiction In Plea Bargaining And Sentence Mitigation: Conversion Of Incarceration To Probation And Rehabilitation Based On Genetic Addiction Risk Severity (Gars) Test, Kenneth Blum, Paul Mullen, Richard Green

St. Mary's Law Journal

In this Article, Dr. Kenneth Blum and his team present the case of a presently abstinent, thirty-five year old alcoholic (“AG”) who has several convictions for DWI. AG has undergone and continues to be engaged in out-patient substance abuse treatment. He entered treatment before adjudication and was mandated by the court to continue treatment to assist in maintaining sobriety. Treatment included the administration of the Genetic Addiction Risk Severity (“GARS”) Test.

AG was facing a probable five-year sentence for his fifth DWI conviction in Bexar County, Texas. However, because AG’s genetic risk results indicated a genetically induced dopamine dysfunction, hypodopaminergia, …

Fall/Winter 2022: Language-Learning Legacy Brings Tokyo Student To St. Norbert, St. Norbert College

St. Norbert College Magazine 2019-2023

Chihiro Sato’s journey to study English at St. Norbert College continues a family legacy begun by her mother, Tomoko Sato, highlighting the enduring impact of the ESL Institute’s immersive language and cultural programs over nearly three decades.

The Diamond, December 9, 2022, Dordt University

Dordt Diamond

• Front Page: Paperwork Delays Cause Problems for International Students; Airband Rocks the BJ Haan; Campus Christmas Events
• News: Peepholes; Dordt's Fall Semester Ends Later Than Previous Years; Dordt Gaming Guild Tabletop War Game Event
• Feature: "Glitch" in Ticketmaster May be its End Game; Iowa Removes Praxis Requirement for Teaching Licensure; FIFA World Cup Held During Classes for the First Time; Terracotta Films; Julie Van Otterloo Returns as a Second-Year Teacher; Small Groups Watch The Chosen
• Opinion: A Perspective on Christian Education as a Requirement; Questioning the Purpose of CORE 140 and 145; What To Do Over …

Voices From The Field: A Critical Incident Study Of Teachers' Perspectives On What Helps And Hinders The Implementation Of Behavior Intervention Plans In The Classroom, Emily Anne Cragun

Theses and Dissertations

Student problem behavior continues to be a major issue in schools for both teachers and students. Teachers often feel they are not provided with enough resources to help them manage this problem behavior. Students who engage in problem behavior tend to struggle socially and academically. When classified with an emotional disturbance, students are especially at risk due to the severity of the problem behavior they exhibit (Brauner & Stephens, 2006). This study examined how function-based interventions can help both teachers and students better manage the effects of problem behavior. There are several factors believed to hinder the effectiveness of function-based …

Principles For Using Remote Data Collection Devices And Deep Learning In Evaluating Social Impact Indicators Of Engineered Products For Global Development, Bryan J. Stringham

Theses and Dissertations

Evaluating the social impacts of engineered products, or effects products have on the daily lives of individuals, is critical to ensuring that products are having positive impacts while avoiding negative impacts and to learning how to improve product designs for a more positive social impact. One approach to quantifying a product's social impact is to use social impact indicators that combine user data in a meaningful way to give insight into the current social condition of an individual or population. However, determining social impact indicators relative to engineered products and individuals in developing countries can be difficult when there is …

Response Of Rotor Blade Flapping In Forward Flight, Yunfei Gao

Mechanical Engineering and Materials Science Independent Study

The article aims to determine the effect of reverse flow on the damping, frequency, and the stability boundaries of helicopter rotor-blade flapping dynamics and to investigate the behavior of the system in the limit of small Lock number and small advance ratio. The system is represented by a linear ordinary differential equation that gives results resembling to experimental data.

Three-Dimensional Imaging And Quantification Of Mouse Ovarian Follicles Via Optical Coherence Tomography, Anh (Blue) Truong

Electrical and Systems Engineering Undergraduate Student Research

Ovarian tissue cryopreservation has been successfully applied worldwide for fertility preservation. Correctly selecting the ovarian tissue with high follicle loading for freezing and reimplantation, increases the likelihood of restoring ovarian function, but it is challenging. In this work, we explore the use of three-dimensional spectral-domain optical coherence tomography (SD-OCT) to identify different follicular stages, especially primary follicles, we compare the identifications with H&E images, and we measure the size and age-related follicular density distribution differences in mice ovaries. We use the thickness of the layers of granulosa cells to differentiate primordial/primary follicles from secondary follicles. The measured dimensions and age-related …

Ways To Decrease Risk Of Postpartum Hemorrhage, Madison Holcomb

Honors Theses

Postpartum hemorrhage (PPH) is the leading preventable cause of maternal mortality (Jena et al., 2022). In fact, it accounts for 25% of maternal deaths globally (Cooper et al., 2022). There is a tremendous need for education to the pregnant population There are methods to decrease the risk that needs to be taught to patients. The education on risk factors should be provided in the in the preconception period and throughout pregnancy. There are several components of educational practice that may improve the knowledge of pregnant individuals. The educational components can be divided into implementations during the antenatal period and the …

Pfas Mass Balance, Donovan Vitale

Honors Theses

First-generation, PFOS-dominant Aqueous Film Forming Foam (AFFF) concentrate of approximately 200 gallons was released to the sewer system from the Kalamazoo/Battle Creek International Airport on March 30, 2021. The AFFF release migrated to the Kalamazoo Water Reclamation Plant (KWRP), raising plant effluent above the Department of Environment, Great Lakes, and Energy (EGLE) PFOS water quality standard for a total of 46 days post-spill, although the influent concentrations exhibited sharp declines after only 7 days. By sampling influent, effluent, and biosolids daily, the only known long duration, high-frequency PFAS data set of an accidental AFFF release was generated. This study has …

Accepting The Monster Within: Addressing Mental Illness Through Young Adult Literature, Jenna Ellis

Honors Theses

This creative research project discusses the importance and practice of implementing a unit on mental health in young adult literature in secondary-level ELA curriculum. The first portion of this thesis is an original short story, entitled “Beneath the Surface,” which portrays a middle-schooler, Leith, whose anxiety manifests itself as a monster. “Beneath the Surface” explores mental illness through a metaphor of the ocean, utilizing water imagery to depict Leith’s experiences with and symptoms of anxiety. Following the short story is an annotated bibliography describing mental health texts for students to read in an ELA unit on mental health as well …

Alterations In The Oral Microbiome Leading To Inflammatory Periodontal Disease, Emma Vlaun

Honors Scholar Theses

The oral cavity contains a complex micro-ecosystem of flora inhabiting a variety of different niches. Some of these niches include saliva, shedding surfaces, and non-shedding surfaces. Biofilms in the oral microbiome, colloquially referred to as dental plaque, can accumulate on non-shedding surfaces, such as natural teeth and other artificial hard parts such as braces, dentures, fillings, and implants. These biofilms are made up of many mutualistic bacteria that stick to each other and adhere to hard surfaces. Scientists speculate that at least 700 different species of bacteria inhabit various parts of the mouth. These bacteria occupy different niches in varying …

High-Resolution Cryo-Em Structure Of The Shigella Virus Sf6 Genome Delivery Tail Machine, Fenglin Li, Chun-Feng David Hou, Ruoyu Yang, Richard Whitehead, Carolyn M. Teschke, Gino Cingolani

Department of Biochemistry and Molecular Biology Faculty Papers

Sf6 is a bacterial virus that infects the human pathogen Shigella flexneri. Here, we describe the cryo–electron microscopy structure of the Sf6 tail machine before DNA ejection, which we determined at a 2.7-angstrom resolution. We built de novo structures of all tail components and resolved four symmetry-mismatched interfaces. Unexpectedly, we found that the tail exists in two conformations, rotated by ~6° with respect to the capsid. The two tail conformers are identical in structure but differ solely in how the portal and head-to-tail adaptor carboxyl termini bond with the capsid at the fivefold vertex, similar to a diamond held over …

Development Of A Crosslinked Osteochondral Xenograft And A Collagen Stabilizing Intra-Articular Injection To Remediate Cartilage Focal Lesions To Prevent Osteoarthritis, Mark Lewis Mosher

Theses and Dissertations

Osteoarthritis is one of the most common causes of disability in adults in America. It is a progressive and degenerative disease where the articular cartilage is broken down and lost from the surfaces of bones causing chronic pain and swelling in the joints, and currently has no cure. The most commonly osteoarthritis starts from a focal lesion on the cartilage surface, which will expand on the surface and downwards through the thickness of the tissue. The current gold standard for correcting cartilage focal lesions is the osteochondral autograft/allograft transplantation (OAT), which replaces the defect with a fresh osteochondral graft. The …