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Kernel Estimation Of Spot Volatility And Its Application In Volatility Functional Estimation, Bei Wu Dec 2022

Kernel Estimation Of Spot Volatility And Its Application In Volatility Functional Estimation, Bei Wu

Arts & Sciences Graduate Student Theses and Dissertations

It\^o semimartingale models for the dynamics of asset returns have been widely studied in financial econometrics. A key component of the model, spot volatility, plays a crucial role in option pricing, portfolio management, and financial risk assessment. In this dissertation, we consider three problems related to the estimation of spot volatility using high-frequency asset returns. We first revisit the problem of estimating the spot volatility of an It\^o semimartingale using a kernel estimator. We prove a Central Limit Theorem with an optimal convergence rate for a general two-sided kernel under quite mild assumptions, which includes leverage effects and jumps of …

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Geometry And Dynamics Of Rolling Systems, Bowei Zhao Dec 2022

Geometry And Dynamics Of Rolling Systems, Bowei Zhao

Arts & Sciences Graduate Student Theses and Dissertations

Billiard systems, broadly speaking, may be regarded as models of mechanical systems in which rigid parts interact through elastic impulsive collision forces. When it is desired or necessary to account for linear/angular momentum exchange in collisions involving a spherical body, a type of billiard system often referred to as no-slip has been used. Previous work indicated that no-slip billiards resemble non-holonomic systems, specifically, systems consisting of a ball rolling on surface. In prior research, such connections were only observed numerically and were restricted to very special surfaces. In this thesis, it is shown that no-slip billiard and rolling systems are …

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Truncated Realized Variations Of Lévy Models: Optimality, Debiasing, And Implementation Approaches, Yuchen Han Dec 2022

Truncated Realized Variations Of Lévy Models: Optimality, Debiasing, And Implementation Approaches, Yuchen Han

Arts & Sciences Graduate Student Theses and Dissertations

Statistical inference for stochastic processes under high-frequency observations has been an active research area in econometrics and financial statistics for over twenty years. In this thesis, we consider some aspects related to the estimation of the volatility of an Itô semimartingale in the presence of Lévy-type jumps, which is of fundamental importance in derivatives pricing evaluation, risk management and portfolio allocation. The main technique we use is the Truncated Realized Variation (TRV) that is both rate- and variance-efficient, in the Cramer-Rao lower bound sense, when jumps are of bounded variation.Motivated by recent results that state that the optimal threshold parameter, …

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Munroe Construction Corp V. Goode Dec 2022

Munroe Construction Corp V. Goode

All Decisions

Court dismisses a holdover proceeding on an unregulated unit because the Notice to Terminate was defective. The landlord gave only 89 - not 90 - days notice of termination as required by statute.

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Virtual Cleaning Of Works Of Art Using Deep Learning Based Approaches, Morteza Maali Amiri Dec 2022

Virtual Cleaning Of Works Of Art Using Deep Learning Based Approaches, Morteza Maali Amiri

Theses

Virtual cleaning of art is a key process that conservators apply to see the likely appearance of the work of art they have aimed to clean, before the process of cleaning. There have been many different approaches to virtually clean artworks but having to physically clean the artwork at a few specific places of specific colors, the need to have pure black and white paint on the painting and their low accuracy are only a few of their shortcomings prompting us to propose deep learning based approaches in this research. First we report the work we have done in this …

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Machine-Learning Classifier To Detect Atrial Fibrillation Based On Facial Action Units, Chongyu Zhu Dec 2022

Machine-Learning Classifier To Detect Atrial Fibrillation Based On Facial Action Units, Chongyu Zhu

Theses

Facial action units (AUs) are numerical representations of indicative facial features drawn by facial landmark localization. Tiny muscular movements on the face can be reflected through facial AUs. In this project, using AUs to diagnose atrial fibrillation (AFib) in real-time is investigated for the first time, and AUs are shown to have a connection with AFib occurrence. Unlike ECG/PPG/VPG, the machine-learning-enabled AFib detector proposed in this project can realize real-time contactless monitoring of AFib continuously in home settings while maintaining the accuracy of AFib detection. ECG data and tablet image snapshots are synchronized to form the dataset that will be …

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“High Fantasy Track.” Dragon Con, Atlanta, Ga. September 1-5, 2022. Reviewed By Tim Lenz, Tim Lenz Dec 2022

“High Fantasy Track.” Dragon Con, Atlanta, Ga. September 1-5, 2022. Reviewed By Tim Lenz, Tim Lenz

Mythprint Book Reviews

Mythprint is the quarterly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local discussion groups.

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The Gallant Edith Bratt: J.R.R. Tolkien’S Inspiration, By Nancy Bunting And Seamus Hamill-Keays. Reviewed By Mattie E. Gustafson., Mattie E. Gustafson Dec 2022

The Gallant Edith Bratt: J.R.R. Tolkien’S Inspiration, By Nancy Bunting And Seamus Hamill-Keays. Reviewed By Mattie E. Gustafson., Mattie E. Gustafson

Mythprint Book Reviews

Mythprint is the quarterly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local discussion groups.

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Serum Lipid Profile Among Sudanese Patients Diagnosed With Hyperthyroidism, Afraagassim Mohammed Yousif, Khalid Abdelbagi Ataelfadeal Dec 2022

Serum Lipid Profile Among Sudanese Patients Diagnosed With Hyperthyroidism, Afraagassim Mohammed Yousif, Khalid Abdelbagi Ataelfadeal

Muthanna Medical Journal

Hyperthyroidism is a term for overactive tissue within the thyroid gland, human hyperthyroidism is accompanied by multiple abnormalities with increased energy expenditure and excessive mobilization and utilization of metabolic substrates. The aim of this study is to investigate the concentration of serum lipid profiles in Sudanese patient with hyperthyroidism in Khartoum state. Analytical case control hospital base study recruited 50 patients diagnosed with hyperthyroidism compare with 50 control group, attended at Military Hospital, Khartoum state from January to April 2021. The results data show that the ages of hyperthyroidism were ranging (20-72 years). TSH and T3 were significantly increased in …

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Comparative Study In The Significance Of The Character Of Christ In The Poetry Of Mahmoud Darwish And Ahmed Shamlou, Seyed Adnan Ashkouri, Zahra Naomi, Saghri Fallahi, Muhammad Ali Mudali Dec 2022

Comparative Study In The Significance Of The Character Of Christ In The Poetry Of Mahmoud Darwish And Ahmed Shamlou, Seyed Adnan Ashkouri, Zahra Naomi, Saghri Fallahi, Muhammad Ali Mudali

Alustath Journal for Human and Social Sciences

Mahmoud Darwish and Ahmed Shamlou are considered among the modern poets in the Arab and Iranian world. The presence of different cultures in their poems is one of the common characteristics between them, which led to the worldwide fame of their poems. Christian thoughts and Christian culture were among the common origins of their poems. Therefore, the presence of Jesus Christ and his stories were noticeable in the poems of both Darwish and Shamlou. By employing this great character in their poems, these two poets were able to give their poetry more depth dimensions on the one hand, and on …

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Al-Munawun In The Holy Qur’An: A Pragmatic Linguistic Approach (Salsabil) As A Mode, Wathiq Galib Hashim Dec 2022

Al-Munawun In The Holy Qur’An: A Pragmatic Linguistic Approach (Salsabil) As A Mode, Wathiq Galib Hashim

Alustath Journal for Human and Social Sciences

The multiplicity of facets and possibilities in the analysis of a specific linguistic issue, or a specific grammatical issue, is a familiar matter that is common in the study of Arabic, indicating the occurrence of disagreement in opinions at the level of a single issue, as occurred in the name Al-Manun (Salsabil) mentioned in the Almighty’s saying: “An eye in it is called Salsabil.” ( [Al-Insan: 18] who was chosen by the research as his field, he saw in it what is sufficient to reveal this phenomenon in the sayings of the people of Arabic and the commentators, and the …

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The Use Of Psychometric Scale Theory In Formulating Gilliam Scale Gars-3 For Diagnosing Autism Spectrum Disorder, Abbas Fadhil Abdulwahid, Muhammad Anwar, Khalid Jamal Jasim Dec 2022

The Use Of Psychometric Scale Theory In Formulating Gilliam Scale Gars-3 For Diagnosing Autism Spectrum Disorder, Abbas Fadhil Abdulwahid, Muhammad Anwar, Khalid Jamal Jasim

Alustath Journal for Human and Social Sciences

The present paper aims to formulate Gilliam Scale GARS-3 for diagnosing autism spectrum disorder (ADS) according to the use of psychometric scale theory. In order to achieve the aim of the paper, the researchers have followed the scientific steps in formulating the scale and verifying the credibility of the translation via checking the accuracy and subjectivity in transferring all the thoughts of the scale. Then, an expert in Arabic language has checked the scale which consists of (58) items of six dimensions. The scale was applied to (500) students inside the governmental and the private centers and on a sample …

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Inferring Adaptation In Social Microbes From Experimental Evolution Under Relaxed Selection, Tyler John Larsen Dec 2022

Inferring Adaptation In Social Microbes From Experimental Evolution Under Relaxed Selection, Tyler John Larsen

Arts & Sciences Graduate Student Theses and Dissertations

Microbes exist against a backdrop of other organisms, and the interactions between microbes have major consequences on their traits, their evolution, and their impact on the world. Microbial interactions and the adaptations that enable them are extremely diverse – they can unlock abilities beyond the reach of individual cells or lead to a population’s destruction, they can be temporary or permanent, they can be between genetically identical cells or different species entirely. The first chapter of this dissertation reviews microbial interactions and the related concept of the evolution of conflict and cooperation.To be certain a trait is an adaptation at …

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Insights Into The Non-Osmoregulatory Function Of A Pollen-Specific Mechanosensitive Ion Channel, Kari Miller Dec 2022

Insights Into The Non-Osmoregulatory Function Of A Pollen-Specific Mechanosensitive Ion Channel, Kari Miller

Arts & Sciences Graduate Student Theses and Dissertations

Pollen, the male gametophyte of flowering plants, delivers the sperm cells to the ovule to carry out sexual reproduction. During this process, the pollen grain undergoes dramatic physical changes. Survival requires careful control of cell mechanics, particularly the balance between protoplast expansion and cell wall resistance. One control mechanism is the use of a mechanosensitive (MS) ion channel, MscS-Like (MSL)8. This pollen-specific protein was previously shown to be essential for pollen survival during hydration and was proposed to function as a tension-gated osmoregulator. However, direct proof of osmoregulation during initial hydration has not yet been found. In fact, studies of …

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Bioinformatics And Cancer Genomics Approaches To Advance Precision Medicine And Elucidate Tumor Mutational Landscapes, Kelsy Cotto Dec 2022

Bioinformatics And Cancer Genomics Approaches To Advance Precision Medicine And Elucidate Tumor Mutational Landscapes, Kelsy Cotto

Arts & Sciences Graduate Student Theses and Dissertations

Next-generation sequencing of DNA and RNA continues to be integrated into pre-clinical and clinical research. However, challenges still remain that impede the translation of findings into an improved understanding of human diseases or clinically actionable alterations. The projects described in this dissertation start with compiling efforts from experts who have identified druggable genes within the human genome, followed by in-depth analyses which characterize the pan-cancer landscape of splice-associated mutations and noncoding, regulatory mutations across multiple subtypes of breast cancer. In Chapters 2 and 3, substantial efforts were made to update the content and the user experience for the drug-gene interaction …

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Generation, Characterization, And Treatment Of Functional Zebrafish Models For Musculoskeletal Disorders, Julia Nicole Whittle Dec 2022

Generation, Characterization, And Treatment Of Functional Zebrafish Models For Musculoskeletal Disorders, Julia Nicole Whittle

Arts & Sciences Graduate Student Theses and Dissertations

Musculoskeletal disorders in humans present with a broad range of phenotypes that vary in severity, onset, and genetic cause. The musculoskeletal system is comprised of complex and diverse tissues that make up the majority of total body mass. Thus, mutations in many different genes with differing structure and function can produce phenotypically similar developmental and morphological defects in the muscle and skeleton. In addition, the muscular and skeletal systems develop non-autonomously, wherein development and function of each will affect development of the other. Thus, mutations in genes responsible for development of this complex system have the potential to influence morphogenesis …

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A War Of Compassion: Challenging The Species Barrier In The Works Of Céline And Léautaud, Dawn Mohrmann Dec 2022

A War Of Compassion: Challenging The Species Barrier In The Works Of Céline And Léautaud, Dawn Mohrmann

Arts & Sciences Graduate Student Theses and Dissertations

Jacques Derrida, when affirming the undeniability of animal suffering in L’Animal que donc je suis, states that there is “une guerre en cours … entre d’une part, ceux qui violent non seulement la vie animale mais jusqu’à ce sentiment de compassion et d’autre part, ceux qui en appellent au témoignage irrécusable de cette pitié” (50). This study investigates the nature of this ongoing war to which Derrida referred. I investigate both the nature of human cruelty and its counterpoint, empathy, which I propose as the response to the anthropocentrism that allows this struggle to continue. Through investigating theories of empathy, …

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Circadian Circuitry And Glioblastoma: Interactions With Behavior, Carcinogenesis, And Clinical Practice., Anna R. Damato Dec 2022

Circadian Circuitry And Glioblastoma: Interactions With Behavior, Carcinogenesis, And Clinical Practice., Anna R. Damato

Arts & Sciences Graduate Student Theses and Dissertations

Glioblastoma (GBM) is the most common primary adult brain tumor diagnosed, with a 15-month prognosis using current standard of care treatment which includes chemotherapy with temozolomide (Temodar, TMZ). Chronotherapy, the practice of considering time of day in treating a disease, has been shown to improve outcome in several cancers, but had not been applied to GBM. Previous work in the lab on a cultured murine mesenchymal GBM cell line showed a time-of-day dependent maximum in sensitivity to TMZ corresponding with the daily peak of Bmal1 and trough of Per2 expression, two core clock genes. Based on this finding, we sought …

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The Enemy Within: An Investigation Of The Intracellular Bacteria In Urinary Tract Infections, Jennie Elizabeth Hazen Dec 2022

The Enemy Within: An Investigation Of The Intracellular Bacteria In Urinary Tract Infections, Jennie Elizabeth Hazen

Arts & Sciences Graduate Student Theses and Dissertations

Urinary tract infections (UTIs) are common diseases that are associated with significant morbidities. Multiple studies have indicated that multiple species of uropathogenesis bacteria invade and persist within bladder epithelial cells as a necessary step of uropathogenesis. Interestingly, many of these species are not canonically associated with intracellular infections. Although the first study describing bacteria within the urothelium was published two decades ago, this critical step of uropathogenesis remains relatively understudied.I established a murine model of community-acquired A. baumannii UTI, a previously unstudied manifestation of the disease. While immunocompetent mice resolved their infections quickly, immunocompromised mice displayed high bacterial burdens throughout …

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A Universal Mechanism Of G Protein Inhibition, Tyson Daniel Todd Dec 2022

A Universal Mechanism Of G Protein Inhibition, Tyson Daniel Todd

Arts & Sciences Graduate Student Theses and Dissertations

G protein coupled receptors transduce a truly staggering number of diverse extracellular signals including chemical messengers, physical force, and even photons into specific cellular responses through their coupling to heterotrimeric G proteins. G proteins amplify the originating signal through their binding to downstream effectors, activating a complex network of overlapping responses that allow the cell to respond perfectly to that specific stimulus. It is critical to the cell that this process is carried out faithfully in order to respond to the myriad environmental cues and avoid injury, exhaustion, and death for the individual cell or the development of pathology if …

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Non-Canonical Beta-Lactam Antibiotics, Brett Wesley Virgin-Downey Dec 2022

Non-Canonical Beta-Lactam Antibiotics, Brett Wesley Virgin-Downey

Arts & Sciences Graduate Student Theses and Dissertations

In canonical β-Lactam antibiotics, such as penicillin, the strained nature of the β-Lactam ring leads to acylation of the catalytic serine in the active site of transpeptidases. In 2018, our lab reported a novel mechanism for monocyclic β-lactam antibiotics in the inhibition of glutamine synthetase (GS) by a natural product, tabtoxinine-β-lactam (TβL) using a 3-hydroxy-β-lactam pharmacophore. This work aims to generalize the β-lactam scaffold from TβL to act as a warhead against ATP-dependent carboxylate-amine ligase enzymes, with dihydrofolate synthetase (DHFS) as the test case. A pure 3-hydroxy-β-lactam warhead was synthesized and ligated both chemically and chemoenzymatically to different pteridine mimics. …

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Dysregulation Of Gene Expression In Non-Photosensitive Trichothiodystrophy, Brittany Townley Dec 2022

Dysregulation Of Gene Expression In Non-Photosensitive Trichothiodystrophy, Brittany Townley

Arts & Sciences Graduate Student Theses and Dissertations

The pre-mRNA life cycle requires intron processing; yet, how intron processing defects influence splicing and gene expression is unclear. Here, we find TTDN1, which is frequently mutated in non-photosensitive trichothiodystrophy (NP-TTD), functionally links intron lariat processing to the spliceosome. The conserved TTDN1 C-terminal region directly binds lariat debranching enzyme DBR1, while its N-terminal intrinsically disordered region (IDR) binds the intron binding complex (IBC). The IDR forms condensates in vitro and is needed for IBC interaction. TTDN1 loss causes significant intron lariat accumulation, as well as splicing and gene expression defects, mirroring phenotypes observed in NP-TTD patient cells. Ttdn1∆/∆ mice recapitulate …

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Tracking Reducing Equivalents Between Cellular Compartments To Understand The Metabolic Demands Of Proliferation, Yahui Wang Dec 2022

Tracking Reducing Equivalents Between Cellular Compartments To Understand The Metabolic Demands Of Proliferation, Yahui Wang

Arts & Sciences Graduate Student Theses and Dissertations

Proliferating cancer cells compartmentalize metabolic reactions, many of which require reducing equivalents. This compartmentalization is functionally important, but it is challenging to study with current technologies. As a consequence, our understanding of proliferating metabolism has been limited. Here, I developed an approach to track reducing equivalents between cellular compartments. By applying this method to a panel of different cell lines under various conditions, I investigated a dysregulated metabolic phenotype in proliferating cells known as “aerobic glycolysis”. Aerobic glycolysis is characterized by an elevated rate of glucose fermentation to lactate irrespective of oxygen availability. Using the NCI-60 cell lines, I first …

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Understanding Gene Regulation With High-Throughput Genome-Integrated Reporter Assays, Clarice Hong Dec 2022

Understanding Gene Regulation With High-Throughput Genome-Integrated Reporter Assays, Clarice Hong

Arts & Sciences Graduate Student Theses and Dissertations

Proper spatiotemporal gene expression depends on specific interactions between cis-regulatory sequences (CRSs) and chromatin modifications at a genomic location. However, we do not yet understand the rules that determine how CRSs work together to influence gene expression. The goal of this thesis is to systematically assay and quantify how different genomic environments interact with CRSs to control gene expression output using a variety of genome-integrated massively parallel reporter assays (MPRAs). First, we tested the hypothesis that core promoters confer specificity by only responding to compatible enhancers and chromatin in specific genomic environments. We measured the activities of hundreds of core …

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The Effect Of Ionization Density In Applications Of Radiation Detection, Dosimetry, And Therapy, Daniel Mulrow Dec 2022

The Effect Of Ionization Density In Applications Of Radiation Detection, Dosimetry, And Therapy, Daniel Mulrow

Arts & Sciences Graduate Student Theses and Dissertations

This dissertation covers a wide range of topics but is linked by the common theme of radiation interacting with materials and studying the result of those interactions. The introduction describes the fundamentals of how radiation interacts with material and how we are able to detect that radiation and the application of how we use those interactions in radiation oncology. The thesis starts with a chapter detailing the temperature dependence of the photophysics in two organic scintillators. This chapter is the foundation for a future study that will look the degree to which these scintillators can distinguish between gammas and neutrons …

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Interpersonal Emotion Regulation In Current And Remitted Major Depressive Disorder: An Experience Sampling Study, Yunjing Liu Dec 2022

Interpersonal Emotion Regulation In Current And Remitted Major Depressive Disorder: An Experience Sampling Study, Yunjing Liu

Arts & Sciences Graduate Student Theses and Dissertations

Individuals with major depressive disorder (MDD) have difficulties regulating emotion on their own. As people also turn to others for help with emotion regulation (i.e., interpersonal emotion regulation [IER]), we examined whether these difficulties extend to IER in current and remitted MDD. We generally expected individuals with current MDD (and remitted MDD to a lesser extent) to utilize IER in distinct ways compared to those with no history of psychiatric disorders (i.e., controls) due to differences in emotional, cognitive, and interpersonal functioning. Using experience sampling, adults with current MDD (n=48), remitted MDD (n=80), and controls (n=87) reported on how frequently …

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Systems Level Analysis Of Organelle Biogenesis In Saccharomyces Cerevisiae, Kiandokht Panjtan Amiri Dec 2022

Systems Level Analysis Of Organelle Biogenesis In Saccharomyces Cerevisiae, Kiandokht Panjtan Amiri

Arts & Sciences Graduate Student Theses and Dissertations

Eukaryotic cells contain hundreds of subcellular structures that serve different functions to maintain cellular homeostasis. A hallmark of Eukaryotic cells is its compartmentalization into membrane-bound organelles. One of the grand challenges in quantitative cell biology is understanding the precision with which cells assemble and maintain subcellular organelles. Despite identification of numerous molecular factors that regulate organelle sizes we lack insight into the quantitative principles underlying organelle size control. We examine organelle sizes from Saccharomyces cerevisiae and human iPS cells with mathematical theory to show that cells can robustly control average fluctuations in organelle size. By demonstrating that organelle sizes obey …

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The Effects Of Nmda Antagonism On Neuronal Activity And Neurovascular Coupling In Non-Human Primate Cortex, Benjamin Thomas Acland Dec 2022

The Effects Of Nmda Antagonism On Neuronal Activity And Neurovascular Coupling In Non-Human Primate Cortex, Benjamin Thomas Acland

Arts & Sciences Graduate Student Theses and Dissertations

The N-methyl-D-aspartate receptor (NMDAR) plays a variety of important roles in the development and function of primate central nervous systems. This thesis describes three nonhuman primate studies that, together, demonstrate that pharmacologically reducing NMDAR activity not only causes dramatic changes in neural activity in cortex, but also changes the relationship between that activity and a key signal often used as its proxy in human studies, the blood-oxygen-level-dependent (BOLD) signal. The first study reveals that NMDA antagonism is sufficient to induce powerful low-frequency modulation of spiking activity and extracellular local field potential (LFP) and discusses the implications of this finding for …

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The Role Of The Neurodevelopmental Disorder Gene Myt1l In Mammalian Brain Development, Jiayang Chen Dec 2022

The Role Of The Neurodevelopmental Disorder Gene Myt1l In Mammalian Brain Development, Jiayang Chen

Arts & Sciences Graduate Student Theses and Dissertations

Recent human genetic studies have associated mutations in a gene called Myelin Transcription Factor 1 Like (MYT1L) with neurodevelopmental disorders (NDDs). Patients with MYT1L loss of function (LoF) mutations (MYT1L Syndrome patients) demonstrate shared symptoms such as microcephaly, attention deficit and hyperactivity disorder (ADHD), and obesity. Despite prior studies showing MYT1L overexpression facilitates neuronal differentiation in vitro, its functions in vivo, especially in the mammalian brain, and how its mutation leads to human disease pathology remains poorly understood. Here, I established the first mouse model of MYT1L Syndrome mimicking a patient specific LoF mutation. I found mice with Myt1l heterozygous …

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Genetic And Transcriptomic Aspects Of Major Depressive Disorder: In Vivo Functional Assays Of Risk-Associated Variation, Candidate Disease Cell Types, And Their Pharmacologic And Sex Interactions, Bernard Mulvey Dec 2022

Genetic And Transcriptomic Aspects Of Major Depressive Disorder: In Vivo Functional Assays Of Risk-Associated Variation, Candidate Disease Cell Types, And Their Pharmacologic And Sex Interactions, Bernard Mulvey

Arts & Sciences Graduate Student Theses and Dissertations

Major depressive disorder (MDD) is a debilitating illness that affects hundreds of millions globally, with substantial personal, medical, economic, and societal consequences. While depression occurs more commonly in females, the biology of the brain and sex underlying this skewed prevalence remains unclarified. This body of work explores two aspects of how biological sex may influence the brain at the level of gene expression: through intrinsic sex differences and through sex-mediated effects of depression risk genetics.The monoamine hypothesis of depression suggests that modulatory neurotransmitters including serotonin and norepinephrine constitute a key axis in development of MDD. Large-scale studies of MDD treatment …

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