Digital Commons Network^™

Association Of Igg N-Glycomics With Prevalent And Incident Type 2 Diabetes Mellitus From The Paradigm Of Predictive, Preventive, And Personalized Medicine Standpoint, Xiaoni Meng, Fei Wang, Xiangyang Gao, Biyan Wang, Xizhu Xu, Youxin Wang, Wei Wang, Qiang Zeng

Research outputs 2022 to 2026

Objectives: Type 2 diabetes mellitus (T2DM), a major metabolic disorder, is expanding at a rapidly rising worldwide prevalence and has emerged as one of the most common chronic diseases. Suboptimal health status (SHS) is considered a reversible intermediate state between health and diagnosable disease. We hypothesized that the time frame between the onset of SHS and the clinical manifestation of T2DM is the operational area for the application of reliable risk assessment tools, such as immunoglobulin G (IgG) N-glycans. From the viewpoint of predictive, preventive, and personalized medicine (PPPM/3PM), the early detection of SHS and dynamic monitoring by glycan biomarkers …

Principles And Philosophies For Speech And Language Therapists Working With People With Primary Progressive Aphasia: An International Expert Consensus, A. Volkmer, J. Cartwright, L. Ruggero, A. Beales, J. Gallée, S. Grasso, M. Henry, R. Jokel, J. Kindell, R. Khayum, M. Pozzebon, E. Rochon, C. Taylor-Rubin, R. Townsend, F. Walker, S. Beeke, Deborah Hersh

Research outputs 2022 to 2026

Purpose:

Primary progressive aphasia (PPA) is a language-led dementia associated with Alzheimer’s pathology and fronto-temporal lobar degeneration. Multiple tailored speech and language interventions have been developed for people with PPA. Speech and language therapists/speech-language pathologists (SLT/Ps) report lacking confidence in identifying the most pertinent interventions options relevant to their clients living with PPA during their illness trajectory.

Materials and methods:

The aim of this study was to establish a consensus amongst 15 clinical-academic SLT/Ps on best practice in selection and delivery of speech and language therapy interventions for people with PPA. An online nominal group technique (NGT) and consequent focus …

Intragranular Nanocomposite Powders As Building Blocks For Ceramic Nanocomposites, Ryan D. Dempsey, Xiaoqing He, Jonathan A. Scott, David W. Lipke

Materials Science and Engineering Faculty Research & Creative Works

A powder-based bottom-up processing scheme is introduced for the production of ceramic nanocomposites. Internal displacement reactions between solid solution powders and metallic reactants proceeding via gaseous intermediates are utilized to generate nanostructured building blocks for the synthesis of ceramic nanocomposites. Subsequent rapid sintering results in ceramic nanocomposites, whose microstructures are inherited from the building blocks. This processing scheme is demonstrated for the production of titanium carbide nanocomposites featuring up to 28 wt.% intragranular tungsten inclusions derived from titanium-tungsten mixed carbide powders. Heat treatment of mixed carbide powders in evacuated ampoules containing titanium sponge and iodine at 1000°C for 24 h …

Final-Stage Densification Kinetics Of Direct Current–Sintered Zrb2, Austin D. Stanfield, Steven M. Smith, Suzana Filipović, Nina Obradović, Vladimir Buljak, Gregory E. Hilmas, William Fahrenholtz

Materials Science and Engineering Faculty Research & Creative Works

Final-stage sintering was analyzed for nominally phase pure zirconium diboride synthesized by borothermal reduction of high-purity ZrO₂. Analysis was conducted on ZrB₂ ceramics with relative densities greater than 90% using the Nabarro–Herring stress–directed vacancy diffusion model. Temperatures of 1900°C or above and an applied uniaxial pressure of 50 MPa were required to fully densify ZrB₂ ceramics by direct current sintering. Ram travel data were collected and used to determine the relative density of the specimens during sintering. Specimens sintered between 1900 and 2100°C achieved relative densities greater than 97%, whereas specimens sintered below 1900°C failed to …

The Effect Of Crystal Anisotropy On Fracture Toughness And Strength Of Zrb2 Microcantilevers, Tamás Csanádi, Ahmad Azizpour, Marek Vojtko, William Fahrenholtz

Materials Science and Engineering Faculty Research & Creative Works

The influence of crystal anisotropy on the micromechanical properties of ceramic grains plays an important role in the design of the macromechanical performance of bulk polycrystalline samples. To this end, the effect of crystal orientation on fracture toughness and strength was investigated by microcantilever bending experiments combined with finite element method (FEM) simulations in grains of a polycrystalline ZrB2 sample. The sample was prepared by hot pressing and the crystal orientations were determined by electron backscatter diffraction after careful surface preparation. The bending tests were carried out on notched and unnotched microcantilevers cut from specific grains along the prismatic (⊥ …

Real-Time Air Gap And Thickness Measurement Of Continuous Caster Mold Flux By Extrinsic Fabry-Perot Interferometer, Abhishek Prakash Hungund, Hanok Tekle, Bohong Zhang, Ronald J. O'Malley, Jeffrey D. Smith, Rex E. Gerald, Jie Huang

Materials Science and Engineering Faculty Research & Creative Works

Mold Flux plays a critical role in continuous casting of steel. Along with many other functions, the mold flux in the gap between the solidifying steel shell and the mold serves as a medium for controlling heat transfer and as a barrier to prevent shell sticking to the mold. This manuscript introduces a novel method of monitoring the structural features of a mold flux film in real-time in a simulated mold gap. A 3-part stainless-steel mold was designed with a 2 mm, 4 mm and, 6 mm step profile to contain mold flux films of varying thickness. An Extrinsic Fabry-Perot …

An Eye Tracking Based Framework For Safety Improvement Of Offshore Operations, Muhammad A. Raza, Raj Kiran, Saima Ghazal, Ziho Kang, Saeed Salehi, Edward Cokely, Jiwon Jeon

Mining Engineering Faculty Research & Creative Works

Offshore drilling operations consist of complex and high-risk processes. Lack of situational awareness in drilling operations has become an important human factor issue that causes safety accidents. Prolonged work shifts and fatigue are some of the crucial issues that impact performance. Eye tracking technology can be used to distinguish the degree of awareness or alertness of participants that might be related to fatigue or onsite distractions. Oculomotor activity can be used to obtain visual cues that can quantify the drilling operators' situational awareness that might enable us to develop warning alarms to alert the driller. Such systems can help reduce …

3d Cfd Simulation Of A Bubble Column With Internals: Validation Of Interfacial Forces And Internal Effects For Local Gas Holdup Predictions, Hayder Al-Naseri, Joshua P. Schlegel, Muthanna H. Al-Dahhan

Nuclear Engineering and Radiation Science Faculty Research & Creative Works

CFD Models (Turbulent Models and Interfacial Forces) Incorporated with the Population Balance Model (PBM) Have Been Validated, Azimuthally, with the Gamma-Ray-Computed Tomography (CT) Results to Address the Effect of the Presence of Internals with Different Arrangements and Diameters. the Superficial Gas Velocity Applied Was Varied from 0.05 to 0.45 M/s. the Results Exhibit the Capability to Predict the Hydrodynamics of the Bubble Column, Further Incorporating the Population Balance Model and Promoting the Prediction of Simulation in High Superficial Gas Velocity. the Effect of Internals Revealed that the Gas Holdup Was Significantly Enhanced in the Bubble Column's Wall Region, While the …

Phenomics: An Integrative Approach To Comparative Developmental Physiology, James Mccoy

School of Biological and Marine Sciences Theses

Phenomics, the high-throughput acquisition of phenotypic data at the scale of the whole organism, has led to considerable advancements in plant biology and medicine, yet applications within animal environmental physiology and evolutionary biology are rare. The main aim of this thesis is to understand what phenomics can contribute to our understanding of Comparative Developmental Physiology (CDP), in terms of how environmental and evolutionary change affects the development of physiological function in aquatic embryos. Additionally, I aim to understand the consequences of changes in high-dimensional phenotyping methods used throughout the thesis within the context of embryonic life history. To achieve this, …

The Effects Of Husbandry On Reproductive Output And Behaviour In Captive Saddle-Billed Storks (Ephippiorhynchus Senegalensis), Arlin Douglas Slater

School of Biological and Marine Sciences Theses

Zoos are required to understand specific husbandry requirements of animals in captivity, and there have been significant developments in husbandry research for captive breeding programmes. However, there is no ‘one size fits all’ and in some species, complications have led to low success and failure in breeding. Saddle-billed stork are notoriously difficult to breed in captivity, with low productivity reported in AZA and EAZA populations. Reproductive output, breeding behaviour and interspecific behaviour were measured in saddle-billed storks within European and American zoological institutions using a questionnaire. The effects of birth origin, enclosure provision, nesting provision and wing condition on reproductive …

Personality And Parental Care In The Corkwing Wrasse (Symphodus Melops), Benjamin Ellis

School of Biological and Marine Sciences Theses

Parental care in many species is a repeatable aspect of the behavioural phenotype, in some cases covarying with other behavioural traits within wider behavioural syndromes. It is well understood that in several freshwater fishes, recreational and commercial fisheries often (directly or indirectly) impact traits concerning parental care adversely, in some cases through selection on covarying behavioural traits. In contrast, studies on commercially fished marine species that exhibit parental care are scarce. The corkwing wrasse (Symphodus melops) is a marine fish with complex reproductive behaviour, with parental males exhibiting nest building and parental care behaviours. This species is also subject to …

Metabolism, Swimming Performance, And A Behavioural Syndrome In Schoolmaster Snapper (Lutjanus Apodus), Peter Malorey

School of Biological and Marine Sciences Theses

Commercial overexploitation and climate change can alter the physiology and behaviour of affected marine organisms, although depending on the environment, species, and severity, intraspecific phenotypic response to such changes can vary greatly. Under the Pace-Of-Life Syndrome (POLS) hypothesis, behaviour, physiology, and life history traits can be linked and thus affected both directly and indirectly by selection targeting any aspect of behavioural physiology. However, such links are often understudied in tropical marine fish, with work needed to better understand the impacts of fisheries and climate change on fish stocks. Moreover, tropical regions have greater reliance on fisheries, thus investigations should focus …

Flaws In The Methodologies For Organic Carbon Analysis In Seagrass Blue Carbon Soils, Oscar Serrano, Ines Mazarrasa, James W. Fourqurean, Eduard Serrano, Jeffrey Baldock, Jonathan Sanderman

Research outputs 2022 to 2026

The ability to accurately measure organic carbon (OC) in marine sediments or soils is overall taken for granted in scientific communities, yet this seemingly mundane task remains a methodological challenge when the soil matrix contains calcium carbonate (CaCO3), creating inaccuracies in Blue Carbon estimates. Here, we compared five common methods combining acidification, combustion, and wet oxidation pre-treatments for determination of OC in sediments and soils containing CaCO3 based on the analyses of artificial soil mixtures made of different OC and CaCO3 contents, and multiple soils from Australian seagrass cores. The results obtained showed that methods involving acidification pre-treatment entailed −17 …

Elevated Plasma Sclerostin Is Associated With High Brain Amyloid-B Load In Cognitively Normal Older Adults, Jun Yuan, Steve Pedrini, Rohith Thota, James Doecke, Pratishtha Chatterjee, Hamid R. Sohrabi, Charlotte E. Teunissen, Inge M. W. Verberk, Erik Stoops, Hugo Vanderstichele, Bruno P. Meloni, Christopher Mitchell, Stephanie Rainey-Smith, Kathryn Goozee, Andrew C. P. Tai, Nicholas Ashton, Henrik Zetterberg, Kaj Blennow, Junjie Gao, Delin Liu, Frank Mastaglia, Charles Inderjeeth, Minghao Zheng, Ralph Martins

Research outputs 2022 to 2026

Osteoporosis and Alzheimer’s disease (AD) mainly affect older individuals, and the possibility of an underlying link contributing to their shared epidemiological features has rarely been investigated. In the current study, we investigated the association between levels of plasma sclerostin (SOST), a protein primarily produced by bone, and brain amyloid-beta (A ) load, a pathological hallmark of AD. The study enrolled participants meeting a set of screening inclusion and exclusion criteria and were stratified into A − (n = 65) and A + (n = 35) according to their brain A load assessed using A -PET (positron emission tomography) imaging. Plasma …

Examining Single Session Peer-Teaching Instructional Approaches On Pre-Service Physical Education Teachers’ Throwing Techniques, Bradley Beseler, Mandy S. Plumb, Michael Spittle, Nicola F. Johnson, Jack T. Harvey, Christopher Mesagno

Research outputs 2022 to 2026

An important role of a Physical Education (PE) teacher is to assist students to develop the fundamental motor skills (FMS) that will allow them to participate in physical activities with competence and confidence. Thus, PE teachers require the knowledge and skills to carry out this crucial task. In the crowded curricula of Physical Education Teacher Education (PETE) programs, there are limited opportunities for pre-service PE teachers to learn how to analyze and perform a large list of motor skills. Our purposes in this study were to determine whether a single session peer-teaching intervention could improve pre-service PE teachers’ short-term non-dominant …

Creating Meaningful Work For Employees: The Role Of Inclusive Leadership, Azadeh Shafaei, Mehran Nejati

Research outputs 2022 to 2026

Meaningfulness is a fundamental psychological need and can result in numerous positive outcomes for employees and organizations. However, little is known about how inclusive leadership can promote employees' sense of meaningful work. Drawing upon self-determination theory, we posit that inclusive leadership enhances meaningful work through creating psychological safety and fostering learning from errors. Inclusive leadership improves work meaningfulness as it contributes to better job attributes. Study hypotheses were tested using a multiple-study research design, including a two-wave field study of 317 full-time employees (Study 1) and a randomized experimental vignette methodology with 440 participants (Study 2). Findings from both studies …

Rethinking Adolescent School Nutrition Education Through A Food Systems Lens, Margaret Miller, Donna Barwood, Amanda Devine, Julie Boston, Sandra Smith, Martin Masek

Research outputs 2022 to 2026

BACKGROUND: Obesity-driven nutrition education in schools does not appear to result in healthier adolescent food choices. This study explored food systems as an alternative pedagogical approach to engage students in nutrition education. METHODS: After playing a food systems computer game, 250 13- to 16-year-old students in 5 Western Australian secondary schools, participated in group discussions to distinguish learning and interests in food systems. Discussion records were thematically coded using constant comparative analysis. RESULTS: Students reported crop growth, food production and food waste, healthier food choices, and food systems as knowledge outcomes of game play. They requested additional content on food …

Identity-Based Edge Computing Anonymous Authentication Protocol, Naixin Kang, Zhenhu Ning, Shiqiang Zhang, Sadaqat Ur Rehman, Muhammad Waqas

Research outputs 2022 to 2026

With the development of sensor technology and wireless communication technology, edge computing has a wider range of applications. The privacy protection of edge computing is of great significance. In the edge computing system, in order to ensure the credibility of the source of terminal data, mobile edge computing (MEC) needs to verify the signature of the terminal node on the data. During the signature process, the computing power of edge devices such as wireless terminals can easily become the bottleneck of system performance. Therefore, it is very necessary to improve efficiency through computational offloading. Therefore, this paper proposes an identity-based …

Comparing Music- And Food-Evoked Autobiographical Memories In Young And Older Adults: A Diary Study, Kelly Jakubowski, Amy M. Belfi, Lia Kvavilashvili, Abbigail Ely, Mark Gill, Gemma Herbert

Psychological Science Faculty Research & Creative Works

Previous Research Has Found that Music Brings Back More Vivid and Emotional Autobiographical Memories Than Various Other Retrieval Cues. However, Such Studies Have Often Been Low in Ecological Validity and Constrained by Relatively Limited Cue Selection and Predominantly Young Adult Samples. Here, We Compared Music to Food as Cues for Autobiographical Memories in Everyday Life in Young and Older Adults. in Two Separate Four-Day Periods, 39 Younger (Ages 18–34) and 39 Older (Ages 60–77) Adults Recorded their Music- and Food-Evoked Autobiographical Memories in Paper Diaries. Across Both Age Groups, Music Triggered More Frequent Autobiographical Memories, a Greater Proportion of Involuntary …

Cavity Induced Collective Behavior In The Polaritonic Ground State, Vasil Rokaj, Simeon I. Mistakidis, H. R. Sadeghpour

Physics Faculty Research & Creative Works

Cavity Quantum Electrodynamics Provides An Ideal Platform To Engineer And Control Light-Matter Interactions With Polariton Quasiparticles. In This Work, We Investigate Collective Phenomena In A System Of Many Particles In A Harmonic Trap Coupled To A Homogeneous Cavity Vacuum Field. The System Couples Collectively To The Cavity Field, Through Its Center Of Mass, And Collective Polariton States Emerge. The Cavity Field Mediates Pairwise Long-Range Interactions And Enhances The Effective Mass Of The Particles. This Leads To An Enhancement Of Localization In The Matter Ground State Density, Which Features A Maximum When Light And Matter Are On Resonance, And Demonstrates A …

Simulation Of Coherent Remission In Planar Disordered Medium, Pablo Jara-Palacios, Ho Chun Lin, Chia Wei Hsu, Hui Cao, Alexey Yamilov

Physics Faculty Research & Creative Works

Waves remitted from a scattering medium carry information that can be used for non-invasive imaging and sensing. Such techniques are usually limited by a low photon budget. Recent progress in optical wavefront shaping has enabled coherent control with an order-of-magnitude enhancement of remission [1]. This experimental study necessitated increasingly demanding numerical simulations. Extending this line of research requires more sophisticated computational techniques capable of simulating multiple instances of even larger systems. Here, we demonstrate that remission geometry can be efficiently simulated using a novel open-source software package [2] Maxwell's Equations Solver with Thousands of Inputs (MESTI). To verify its numerical …

Quantum Electrodynamics Of Dicke States: Resonant One-Photon Exchange Energy And Entangled Decay Rate, Ulrich D. Jentschura, Chandra M. Adhikari

Physics Faculty Research & Creative Works

We calculate the fully retarded one-photon exchange interaction potential between electrically neutral, identical atoms, one of which is assumed to be in an excited state, by matching the scattering matrix (S matrix) element with the effective Hamiltonian. Based on the Feynman prescription, we obtain the imaginary part of the interaction energy. Our results lead to precise formulas for the distance-dependent enhancement and suppression of the decay rates of entangled superradiant and subradiant Dicke states (Bell states), as a function of the interatomic distance. The formulas include a long-range tail due to entanglement. We apply the result to an example calculation …

Engaging Indigenous Community Towards A Talaandig Language Learning And Cultural Sustainability, Geraldine D. Villaluz, Rscj, Phd., Rita May P. Tagalog, Edd, Isrm, Aduna L. Saway Bai

ASEAN Journal of Community Engagement

The decreased use of indigenous language among the young generation of an indigenous community in the Southern Philippines has introduced apprehension among cultural practitioners, the chief administrator, and the community of elders. With the articulated need to strengthen language learning and sustain the culture among the young Talaandig members of the tribe, the chief administrator has proposed a community engagement process for addressing this concern. This study explores the Talaandig language learning and cultural sustainability through the active involvement of an indigenous community of parents–teachers, leaders, and culture practitioners of the Talaandig tribe in Bukidnon, Philippines. Indigenous research methods and …

Chopin’S Polonaise In Ab Major, Op.53: Constructing An Informed Interpretation, Arielle X. Lu

Theses : Honours

This dissertation centers around Chopin’s Polonaise in Ab Major and charts the various steps undertaken in forming an interpretation of the work. Four approaches inform the interpretation: 1) early prints and manuscripts, 2) later 19th-century performer editions, 3) analysis of historic recordings, and 4) interacting with relevant secondary literature. The results offer both new findings in relation to the broader field of Chopin studies and also offer scholar-performers new possibilities and paradigms in the performance of Chopin’s piano music.

Nanomaterials-Based Biosensors For The Detection Of Prostate Cancer Biomarkers: Recent Trends And Future Perspective, Baljit Singh, Shiliang Ma, Tony O. Hara, Sargun Singh

Articles

Cancer is among the leading causes of death and an important barrier to improving life expectancy globally. Prostate cancer is the second most common cancer in men worldwide. The detection of biomarkers in body fluids is the key topic for the diagnosis and prognosis of prostate cancer. Despite advances in prostate cancer detection methods, therapeutic agents and new biomarkers, prostate cancer remains a serious challenge. Prostate-specific antigen (PSA) is widely recognized as an important biomarker for the diagnosis of prostate cancer although researchers have also investigated the use of alternative biomarkers. Design and development of novel biosensors for prostate cancer …

Assessing The Evidential Value Of Mental Fatigue And Exercise Research, Darias Holgado, Cristian Mesquida, Rafael Roman-Caballero

Articles

It has often been reported that mental exertion, presumably leading to mental fatigue, can negatively affect exercise performance; however, recent findings have questioned the strength of the effect. To further complicate this issue, an overlooked problem might be the presence of publication bias in studies using underpowered designs, which is known to inflate false positive report probability and effect size estimates. Altogether, the presence of bias is likely to reduce the evidential value of the published literature on this topic, although it is unknown to what extent. The purpose of the current work was to assess the evidential value of …

Now You See Them, Now You Don’T: International Court-Appointed Experts, Wartime Reparations, And The Drc V. Uganda Case, Sean D. Murphy, Yuri Parkhomenko

GW Law Faculty Publications & Other Works

One intersection between scholarship and practice in international humanitarian law (IHL) is observable in international litigation concerning violations of the law of war. An interesting example in this regard recently arose in the case before the International Court of Justice (ICJ) by the Democratic Republic of the Congo against Uganda for war-related claims. At the reparations phase, the Court decided not to rely solely on the submissions of the Parties, but to task certain scholars and other experts to answer evidentiary questions. Yet, when the Court’s judgment was issued in February 2022, the role of these experts turned out to …

The Heritage Of The Articles On State Responsibility For The International Law Commission, Sean D. Murphy

GW Law Faculty Publications & Other Works

In the two decades since their adoption in 2001, the International Law Commission (ILC)’s Articles on the Responsibility of States for Internationally Wrongful Acts (ASR) have had an extraordinary influence, not just on the field of international law generally, but also on the work of the ILC itself. Indeed, the ILC concluded four projects that directly resulted from or were closely related to the ASR in the first decade after its adoption. Moreover, references to the ASR have worked their way into most (albeit not all) of the ILC topics completed since 2001.

Yet those express references tell just part …

Congressional Testimony: Shareholder Proposals, Index Fund Voting And The Need For Proxy Advisor Reform, Lawrence A. Cunningham

GW Law Faculty Publications & Other Works

This Congressional testimony, requested by the House Financial Services Committee, reviews the history and current state of the federal shareholder proposal rule and how it has been seized by special interests to push agendas at odds with shareholder interests; ponders the conundrum that passive investment funds deign to actively vote shares without either knowledge or authority; and laments how proxy advisors, intended to support such passive funds, make matters worse through a lack of both accountability and incentives to promote accuracy rather than expediency. Congress should restore the legitimacy of the shareholder proposal process, revisit and/or eliminate voting by index …

How To Make A Zoning Atlas 2.0: The Official Methodology Of The National Zoning Atlas, Sara C. Bronin, Scott Markley, Aline Fader, Evan Derickson

GW Law Faculty Publications & Other Works

This methodology, How to Make a Zoning Atlas 2.0, followed on How to Make a Zoning Atlas and was used for a period by the National Zoning Atlas team. It has since been superseded in several key respects and no longer reflects the current process, but is maintained here for historical reference. The National Zoning Atlas has two workflows – one involving analysis of zoning texts, the other involving analysis of zoning maps – the products of which are merged and published to an online, interactive map. This methodology tracks methods used to create both workflows, giving zoning code and …