Digital Commons Network^™

Aerospace Senior Design Project, In-Orbit Manufacturing Process Of Electronic Enclosures, Alan O'Neal, George Pitcock, Audrey Yewo

Senior Design Project For Engineers

This report presents the final design of A-MOD's groundbreaking in-orbit electronic enclosure manufacturing device. The detailed design, encompassing analysis, specifications, and component specifics, showcases the feasibility of the proposed system. With objectives met, the report navigates through the concept of operations, validation and verification processes, critical design of mechanical and electrical components, software integration, performance specifications, and a comprehensive risk assessment. A-MOD's design revolutionizes space technology by proposing a device capable of manufacturing electronic enclosures in orbit, reducing costs and optimizing resources. Thorough validation and verification procedures ensure the system's adherence to stringent requirements, covering precision, quality, thermal resilience, and …

Investigating Telomere Lengths In Chestnut-Crowned Babblers, Gabriella Rose Beberg

Honors Thesis

Telomeres are chromosomal elements that protect and maintain genes as DNA replicates in many organisms. As individuals age and DNA replicates, telomeres often shorten; thus, telomere length often corresponds with an individual’s lifespan, and early-life decreases in telomere length can be predictive of longevity. Here, I investigated the relationship between telomere length and developmental environment in a cooperatively breeding species, the chestnut-crowned babbler (Pomatostomus ruficeps; CCB). Cooperative species are unique, as some individuals give up their own breeding opportunities to help rear the offspring of others; further, cooperative breeding systems generate considerably more variation in adult carers, which …

Residential Indoor Air Quality Study – Assessment And Mitigation, Giovanni Cerrato

Mechanical Engineering Theses

An increased awareness in residential indoor air quality (IAQ) has led to an increase in technologies that assist in improving IAQ. Two such technologies include Electro-static (ES) air cleaners and Photocatalytic Oxidizing (PCO) air cleaners. ES air cleaners remove particulate matter from indoor air, but are known to emit ozone, a contaminant, as a by-product. PCO air cleaners abate gaseous pollutants (i.e., Volatile Organic Compounds, VOCs); however, a lack of testing standards creates confusion about their effectiveness in improving IAQ in a real residential home. On the other hand, environmental variables such as temperature and humidity were found to affect …

Finding Ideal Parameters For Recycled Material Fused Particle Fabrication-Based 3d Printing Using An Open Source Software Implementation Of Particle Swarm Optimization, Shane Oberloier, Nicholas G. Whisman, Joshua M. Pearce

Michigan Tech Publications

As additive manufacturing rapidly expands the number of materials including waste plastics and composites, there is an urgent need to reduce the experimental time needed to identify optimized printing parameters for novel materials. Computational intelligence (CI) in general and particle swarm optimization (PSO) algorithms in particular have been shown to accelerate finding optimal printing parameters. Unfortunately, the implementation of CI has been prohibitively complex for noncomputer scientists. To overcome these limitations, this article develops, tests, and validates PSO Experimenter, an easy-to-use open-source platform based around the PSO algorithm and applies it to optimizing recycled materials. Specifically, PSO Experimenter is used …

A Phase I Trial Of Bevacizumab And Temsirolimus In Combination With Valproic Acid In Advanced Solid Tumors, Blessie Elizabeth Nelson, Apostolia M Tsimberidou, Xueyao Fu, Siqing Fu, Vivek Subbiah, Anil K Sood, Jordi Rodon, Daniel D Karp, George Blumenschein, Scott Kopetz, Shubham Pant, Sarina A Piha-Paul

Faculty, Staff and Student Publications

BACKGROUND: Preclinical models suggest synergy between anti-angiogenesis therapy, mammalian target of rapamycin (mTOR), and histone deacetylase inhibitors to promote anticancer activity.

METHODS: This phase I study enrolled 47 patients between April 2012 and 2018 and determined safety, maximum tolerated dose (MTD), and dose-limiting toxicities (DLTs) when combining bevacizumab, temsirolimus, and valproic acid in patients with advanced cancer.

RESULTS: Median age of enrolled patients was 56 years. Patients were heavily pretreated with a median of 4 lines of prior therapy. Forty-five patients (95.7%) experienced one or more treatment-related adverse events (TRAEs). Grade 3 TRAEs were lymphopenia (14.9%), thrombocytopenia (8.5%), and mucositis …

Evaluation Of Various Turbulence Models For Turbulent Separated Flow Over A Model Two-Dimensional Bump, Xuehui Qian

Mechanical Engineering and Materials Science Independent Study

In this paper, performance of several turbulence models is evaluated by computing the turbulent separated flow over a 2D bump using the RANS equations. The turbulence models considered are the Spalart-Allmaras (SA), SST k-ω, and Wray-Agarwal (WA) models. The geometry of the 2D bump is the centerline geometry of the NASA/Virginia Tech (VT) 3D BeVERLI hill bump. Since the experimental data is available only for the 3D bump, the goal of this paper is to compare the numerical solutions using the three turbulence models on a series of grids from coarse to fine. The experimental data of the 3D bump …

Public Mental Health Through Social Media In The Post Covid-19 Era, Deepika Sharma, Jaiteg Singh, Babar Shah, Farman Ali, Ahmad Ali Alzubi, Mallak Ahmad Alzubi

All Works

Social media is a powerful communication tool and a reflection of our digital environment. Social media acted as an augmenter and influencer during and after COVID-19. Many of the people sharing social media posts were not actually aware of their mental health status. This situation warrants to automate the detection of mental disorders. This paper presents a methodology for the detection of mental disorders using micro facial expressions. Micro-expressions are momentary, involuntary facial expressions that can be indicative of deeper feelings and mental states. Nevertheless, manually detecting and interpreting micro-expressions can be rather challenging. A deep learning HybridMicroNet model, based …

Ultrafast Electronic Relaxation Pathways Of The Molecular Photoswitch Quadricyclane, Kurtis D. Borne, Joseph C. Cooper, Michael N. R. Ashfold, Julien Bachmann, Surjendu Bhattacharyya, Rebecca Boll5, Matteo Bonanomi, Michael Bosch, Carlo Callegari, Martin Centurion, Marcello Coreno, Basile F. E. Curchod, Miltcho B. Danailov, Alexander Demidovich, Michele Di Fraia, Benjamin Erk, Davide Faccialà, Raimund Feifel, Ruaridh J. G. Forbes, Christopher S. Hansen, David M. P. Holland, Rebecca A. Ingle, Roland Lindh, Lingyu Ma, Henry G. Mcghee, Sri Bhavya Muvva, Joao Pedro Figueira Nunes, Asami Odate, Shashank Pathak, Oksana Plekan, Kevin C. Prince, Primoz Rebernik, Arnaud Rouzée, Artem Rudenko, Alberto Simoncig, Richard J. Squibb, Anbu Selvam Venkatachalam, Caterina Vozzi, Peter M. Weber, Adam Kirrander, Daniel Rolles

Martin Centurion Publications

The light-induced ultrafast switching between molecular isomers norbornadiene and quadricyclane can reversibly store and release a substantial amount of chemical energy. Prior work observed signatures of ultrafast molecular dynamics in both isomers upon ultraviolet excitation but could not follow the electronic relaxation all the way back to the ground state experimentally. Here we study the electronic relaxation of quadricyclane after exciting in the ultraviolet (201 nanometres) using time-resolved gas-phase extreme ultraviolet photoelectron spectroscopy combined with non-adiabatic molecular dynamics simulations. We identify two competing pathways by which electronically excited quadricyclane molecules relax to the electronic ground state. The fast pathway (<100 femtoseconds) is distinguished by effective coupling to valence electronic states, while the slow pathway involves initial motions across Rydberg states and takes several hundred femtoseconds. Both pathways facilitate interconversion between the two isomers, albeit on different timescales, and we predict that the branching ratio of norbornadiene/ quadricyclane products immediately after returning to the electronic ground state is approximately 3:2.

Bikram Singh V. Doris Hawkins

All Decisions

The tenant moved to dismiss a holdover proceeding brought by their landlord. The landlord had sought to evict her after accepting funds from the COVID-19 emergency rental assistance program (ERAP) and then terminating her tenancy. The tenant argued that the ERAP statute barred the landlord from terminating her tenancy within one year of accepting the funds. The court agreed with the tenant and dismissed the proceeding.Key Legal Points:Accepting ERAP funds prevents a landlord from terminating a tenancy for one year, even if the eviction proceeding is not filed until after the year is up.Landlords cannot evict tenants for non-payment of …

Impact Of Irrigation On Vulnerability Of Winter Wheat Under Extreme Climate Change Scenario: A Case Study Of North China Plain, Yulian Gao, Lin Wang, Yaojie Yue

Department of Agricultural and Biological Systems Engineering: Faculty Publications

An inadequate understanding of the impacts of adaptation countermeasures tends to exaggerate the adverse e􀀀ects of climate change on agricultural systems. Motivated by proposing reasonable climate change adaptation countermeasures, the present study applied the EPIC model to quantify the impacts of climate change and irrigation changes with future socioeconomic development on agricultural production. Winter wheat yield losses using dynamic irrigation parameters in the North China Plain (NCP) from 2010 to 2099 under a scenario coupling climate change and future socioeconomic development (RCP8.5-SSP3), and those under an extreme climate change scenario (RCP8.5), were simulated. Results show that EPIC model demonstrates superior …

Contextualizing Singlehood Among Young Adults: Exploring The Meanings And Perceived Reasons For Being Single, Jonathon J. Beckmeyer, Tyler B. Jamison

Faculty Publications

Objective: We explored how young adults discussed their experiences with singlehood and their reasons for being single.

Background: Despite singlehood being normative during young adulthood, less research has focused on the diversity of singlehood compared to that of romantic involvement.

Method: In Study 1, 35 young adults participated in in-depth qualitative interviews about their romantic histories. We explored singlehood meanings and reasons in the context of their relationship histories. In Study 2 we used data from 155 single young adults to explore the factor structure, internal reliability, and initial validity of the Reasons for Being Single (RBS) scale, which we …

An Educational Intervention To Increase Knowledge And Awareness Of Hypertension Among Nurses, Sylvia Kabba

Walden Dissertations and Doctoral Studies

No abstract provided.

Establishing A Novel Lipid-Polyamine Metabolic Connection To Virus Replication, Yazmin Edith Cruz Pulido

Dissertations

Polyamines are small positively charged alkylamines found in all living cells. These ubiquitous molecules have been found to play a variety of roles ranging from stabilizing nucleic acids (DNA and RNA) to cellular proliferation. Studies have also identified roles for polyamines in viral packaging and viral enzyme function. However, the role of polyamines on cellular components and their effect on viral replication is less known. In our efforts to identify the lipid-polyamine metabolic connection to virus replication we utilized a human hepatocyte cell line in which polyamines were depleted via pharmacological or genetic approaches and studied the effects on lipid …

An Analysis Of The Efficacy Of Disciplinary Methods, William Hewitt

Masters Projects

The practice of punitive discipline is the most common response to misbehavior in American school systems, despite having no evidence to support its continued use. However, there is research that demonstrates its active harm to students in multiple capacities. Punitive discipline has been found to only exacerbate students’ behavior issues, as well as negatively impact their academic performance. Additionally, research has pointed out that punitive discipline impacts students of minority demographics at a significantly higher rate than students belonging to majority demographics. More research in the way of alternative restorative policies, such as Positive Behavior Interventions and Supports (PBIS), is …

Enlightenment Ideals And Belief In Progress In The Run-Up To The Industrial Revolution: A Textual Analysis, Ali Almelhem, Murat Iyigun, Austin Kennedy, Jared Rubin

ESI Working Papers

We trace the evolution of the language of science, religion, and political economy in the centuries leading to the British Industrial Revolution. Using textual analysis of 264,443 works printed in England between 1500 and 1900, we test whether British culture manifested a belief in progress associated with science and industry. Our analysis yields three main findings. First, there was a separation in the languages of science and religion beginning in the mid-18th century. Second, volumes using language at the nexus of science and political economy became more progress-oriented during the Enlightenment. Third, volumes using industrial language—especially those at the science-political …

Review Of "Three In One: Analogies For The Trinity", Steve Emerson

The Christian Librarian

No abstract provided.

Assessing Generalization Of Behavioral Interventions In Teaching Independent Play Skills To Individuals With Autism Spectrum Disorder: A Systematic Review, David Anthony Defranco

Seton Hall University Dissertations and Theses (ETDs)

A myriad of evidence-based practices has been effective in teaching independent play skills to individuals with Autism Spectrum Disorder (ASD). These interventions include video modeling, activity schedules, task correspondence training, task organization, individual work systems, and matrix training. This systematic review is aimed at examining the various behavioral interventions used to teach independent play skills to children and adolescents with ASD as the independent play literature will be evaluated to see if generalization was programmed for and assessed within the study. As one of the main dimensions of behavior analysis, generalization of skills, specifically independent play skills, is important to …

Review Of "40 Questions About Women In Ministry", Keilah Villa

The Christian Librarian

No abstract provided.

Antibody Binding Captures High Energy State Of An Antigen: The Case Of Nsp1 Sars-Cov-2 As Revealed By Hydrogen-Deuterium Exchange Mass Spectrometry, Ravi Kant, Nawneet Mishra, Michael L Gross

2020-Current year OA Pubs

We describe an investigation using structural mass spectrometry (MS) of the impact of two antibodies, 15497 and 15498, binding the highly flexible SARS-CoV-2 Nsp1 protein. We determined the epitopes and paratopes involved in the antibody-protein interactions by using hydrogen-deuterium exchange MS (HDX-MS). Notably, the Fab (Fragment antigen binding) for antibody 15498 captured a high energy form of the antigen exhibiting significant conformational changes that added flexibility over most of the Nsp1 protein. The Fab for antibody 15497, however, showed usual antigen binding behavior, revealing local changes presumably including the binding site. These findings illustrate an unusual antibody effect on an …

Rupturing Tradition: Theorizing Black Women’S Place In The Discipline Through The Disruptive Rhetoric Of Sanctuary, Celnisha Leta Dangerfield

Electronic Theses and Dissertations Archive

Black women need refuge from physical, mental, emotional and rhetorical violence. However, refuge that does not foster liberation can never offer the full protection of sanctuary. Black women uniquely understand that the only way to ensure full access to sanctuary is by circumventing place. Yet, people and scholarly disciplines overlook their valuable, experiential awareness of place. This dissertation takes an intersectional approach to place by analyzing Black women’s contributions to the rich rhetorical tradition. When we look to the past for guidance, it is easy to see Black women’s struggles are not bound by place or time. An analysis of …

Employment Leave For Early Pregnancy Endings: A Biopolitical Reproductive Governance Analysis In England And Wales, Al Middlemiss, I Boncori, J Brewis, J Davies, Vl Newton

School of Nursing and Midwifery

When a pregnancy ends in England and Wales, statutory time away from paid employment is limited to circumstances where there is a live birth or stillbirth. Forms of leave, such as Maternity Leave or Paternity Leave, depend on parental status derived from the civil registration of a new person or a post-viability stillbirth. Other early pregnancy endings, such as miscarriage or abortion, do not provide specific time off work after pregnancy. This paper uses the concept of reproductive governance to analyze current and shifting biopolitical truth discourses, strategies of intervention, and modes of subjectification around post-pregnancy leaves. It shows how …

Advanced Diffusion Mri Technique And Applications In Placenta And Brain, Zhexian Sun

McKelvey School of Engineering Graduate Student Theses & Dissertations

Among a series of contrasts of MRI, diffusion MRI (dMRI) is different from conventional MRI by its ability to capture information about the random movement of water molecules and their interaction with local tissue microstructures. This capability holds the potential to reveal intricate subvoxel microstructural information linked to pathological changes, offering potential imaging biomarkers. A higher-order diffusion analysis model helps to yield more accurate and specific parameters but requires more extensive parameter tuning and higher image quality. In this study, we firstly fine-tuned the previously developed diffusion basis spectrum imaging (DBSI) method to strike a balance between efficiency and accuracy …

Lecturers’ Skills To Evaluate Information And Use Information Effectively As Correlates Of Digital Library Resources Utilization In Nigeria, Joy Iguehi Ikenwe, Ogagaoghene Uzezi Idhalama

Library Philosophy and Practice (e-journal)

The study investigates lecturers’ skills to evaluate information and use information effectively as correlates of digital library resources utilization in Nigeria. Research questions were, what is the correlation between lecturers’ skills to evaluate information and digital library resources utilization in Southern Nigeria? and what is the correlation between lecturers’ skills to use information effectively and digital library resources utilization in Southern Nigeria? The two hypotheses are: Ho 1: Lecturers' skill to evaluate information does not have a significant relationship with the utilization of digital library resources. Ho 2: Lecturers' skill to use information effectively does not have a …

Allelic Strengths Of Encephalopathy-Associated Uba5 Variants Correlate Between In Vivo And In Vitro Assays, Xueyang Pan, Albert N Alvarez, Mengqi Ma, Shenzhao Lu, Michael W Crawford, Lauren C Briere, Oguz Kanca, Shinya Yamamoto, David A Sweetser, Jenny L Wilson, Ruth J Napier, Jonathan N Pruneda, Hugo J Bellen

Faculty, Staff and Students Publications

Protein UFMylation downstream of the E1 enzyme UBA5 plays essential roles in development and endoplasmic reticulum stress. Variants in the UBA5 gene are associated with developmental and epileptic encephalopathy 44 (DEE44), an autosomal recessive disorder characterized by early-onset encephalopathy, movement abnormalities, global developmental delay, intellectual disability, and seizures. DEE44 is caused by at least 12 different missense variants described as loss of function (LoF), but the relationships between genotypes and molecular or clinical phenotypes remain to be established. We developed a humanized UBA5 fly model and biochemical activity assays in order to describe in vivo and in vitro genotype–phenotype relationships …

Immunoproximity Biotinylation Reveals The Axon Initial Segment Proteome, Wei Zhang, Yu Fu, Luxin Peng, Yuki Ogawa, Xiaoyun Ding, Anne Rasband, Xinyue Zhou, Maya Shelly, Matthew N Rasband, Peng Zou

Faculty, Staff and Students Publications

The axon initial segment (AIS) is a specialized neuronal compartment required for action potential generation and neuronal polarity. However, understanding the mechanisms regulating AIS structure and function has been hindered by an incomplete knowledge of its molecular composition. Here, using immuno-proximity biotinylation we further define the AIS proteome and its dynamic changes during neuronal maturation. Among the many AIS proteins identified, we show that SCRIB is highly enriched in the AIS both in vitro and in vivo, and exhibits a periodic architecture like the axonal spectrin-based cytoskeleton. We find that ankyrinG interacts with and recruits SCRIB to the AIS. However, …

Grifters, Roger Mensink

Valparaiso Fiction Review

No abstract provided.

You Bury Me, William O'Reilly

Valparaiso Fiction Review

No abstract provided.

Evaluating Militant Decision-Making With Information Science: The Irish Republican Movement During The "Troubles", Joshua C. Eastin, Emily Kalah Gade, Michael Gabbay

Political Science Faculty Publications and Presentations

Why do militant groups decide to escalate or deescalate their use of violence in conflict? Examining the case of the “Troubles” in Northern Ireland, we analyze groups that adopt violence as a political strategy and evaluate factors that influence its application. To do so, we adopt a novel empirical approach to the study of militant groups. Drawn from information science, this approach enables estimation of variable influence and uncertainty within structured case studies, and is thus ideal for topics such as militant decision-making where systematic data collection is difficult.

Reassessment Of Amblyscirtes Hegon (Hesperiidae) As A Complex Of Four Distinct Species Revealed By Genomic Analysis, Harry Pavulaan, Ricky Patterson, Nick V. Grishin

The Taxonomic Report of the International Lepidoptera Survey

After the discovery of a unique phenotype in the southern United States with a different ventral ground color than nominotypical Amblyscirtes hegon (Scudder, 1863), which occurs in the northeastern United States, genomic analysis revealed that A. hegon is a species complex. Phenotypic, genitalic, and genomic differences of the complex are presented here. Four species are identified: A. hegon; A. nemoris (W. H. Edwards, 1864), stat. rest.; A. matheri Patterson, Pavulaan & Grishin, sp. n. (TL: USA, Mississippi, Warren County); and A. gelidus Grishin, Patterson & Pavulaan, sp. n. (TL: USA, Michigan, Van Buren County).

Episode 6: For The Kids, Sara Gras

Season 01

When I started thinking about how to address the issue of trans exclusion from youth sports, I knew I needed to include the culture/industry of youth sports as part of the discussion. The pressure to compete and perform at a high level in athletics is reaching kids earlier than ever before, facilitated by parents who see success in sports as the ticket to success in life. This episode explores the relationship between the increased parental investment in kids' athletic achievements and the social acquiescence to the exclusion of trans kids from sports.

Kirsten Jones
Peak Performance Coach, Podcast Host, Author …