Digital Commons Network^™

Elovanoid-N34 Modulates Txnrd1 Key In Protection Against Oxidative Stress-Related Diseases, Jorgelina M. Calandria, Surjyadipta Bhattacharjee, Sayantani Kala-Bhattacharjee, Pranab K. Mukherjee, Yuehan Feng, Jakob Vowinckel, Tobias Treiber, Nicolas G. Bazan

School of Graduate Studies Faculty Publications

The thioredoxin (TXN) system is an NADPH + H+/FAD redox-triggered effector that sustains homeostasis, bioenergetics, detoxifying drug networks, and cell survival in oxidative stress-related diseases. Elovanoid (ELV)-N34 is an endogenously formed lipid mediator in neural cells from omega-3 fatty acid precursors that modulate neuroinflammation and senescence gene programming when reduction-oxidation (redox) homeostasis is disrupted, enhancing cell survival. Limited proteolysis (LiP) screening of human retinal pigment epithelial (RPE) cells identified TXNRD1 isoforms 2, 3, or 5, the reductase of the TXN system, as an intracellular target of ELV-N34. TXNRD1 silencing confirmed that the ELV-N34 target was isoform 2 or 3. This …

Nutrient And Microbiome-Mediated Plant–Soil Feedback In Domesticated And Wild Andropogoneae: Implications For Agroecosystems, Amanda Quattrone, Yuguo Yang, Pooja Yadav, Karrie A. Weber, Sabrina E. Russo

School of Biological Sciences: Faculty Publications

Plants influence the abiotic and biotic environment of the rhizosphere, affecting plant performance through plant–soil feedback (PSF). We compared the strength of nutrient and microbemediated PSF and its implications for plant performance in domesticated and wild grasses with a fully crossed greenhouse PSF experiment using four inbred maize genotypes (Zea mays ssp. mays b58, B73- wt, B73-rth3, and HP301), teosinte (Z. mays ssp. parviglumis), and two wild prairie grasses (Andropogon gerardii and Tripsacum dactyloides) to condition soils for three feedback species (maize B73-wt, teosinte, Andropogon gerardii). We found evidence of negative …

Mutational Analysis Of The Nitrogenase Carbon Monoxide Protective Protein Cown Reveals That A Conserved C‑Terminal Glutamic Acid Residue Is Necessary For Its Activity, Dustin L. Willard, Joshuah J. Arellano, Mitch Underdahl, Terrence M. Lee, Avinash S. Ramaswamy, Gabriella Fumes, Agatha Kliman, Emily Y. Wong, Cedric P. Owens

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Nitrogenase is the only enzyme that catalyzes the reduction of nitrogen gas into ammonia. Nitrogenase is tightly inhibited by the environmental gas carbon monoxide (CO). Many nitrogen fixing bacteria protect nitrogenase from CO inhibition using the protective protein CowN. This work demonstrates that a conserved glutamic acid residue near the C-terminus of Gluconacetobacter diazotrophicus CowN is necessary for its function. Mutation of the glutamic acid residue abolishes both CowN’s protection against CO inhibition and the ability of CowN to bind to nitrogenase. In contrast, a conserved C-terminal cysteine residue is not important for CO protection by CowN. Overall, this work …

Policy Review And Recommendation For Secondary Education Np-Led Clinics In The Southeastern United States, Shiney Alex Jacob

Student Scholarly Projects

Secondary-level education involves adolescent children aged 11-12 years to 18-19 with unique healthcare needs. Their healthcare is of significant importance as they are transitioning to adulthood, and a majority of them lack access to primary healthcare needs. Advanced Practice Registered Nurses/Nurse Practitioners (APRNs/NPs) provide high-quality, cost-effective, and evidence-based care to people across the lifespan, and there is minimal utilization of their services in meeting the primary care needs of adolescents at the secondary school level. The purpose of the policy project was to determine if current policies and practices related to school health services in three southeastern states of the …

The Accuracy Of Automatic And Human Live Captions In English, Pablo Romero-Fresco, Nazaret Fresno

Writing and Language Studies Faculty Publications

Closed captions play a vital role in making live broadcasts accessible to many viewers. Traditionally, stenographers and respeakers have been in charge of their production, but this scenario is changing due to the steady improvements that automatic speech recognition has undergone in recent years. This technology is being used to create intralingual live captions without human assistance and broadcasters have begun to explore its use. As a result, human and automatic captions co-exist now on television and, while some research has focused on the accuracy of human live captions, comprehensive assessments of the accuracy and quality of automatic captions are …

Living In Untranslatability--Performance Art In China And Usa, Ziyun Ma

Masters Theses

This thesis embodies discontinuities in performance art and its non-equivalent Chinese term “行 为艺术” between language and cultural context into a migrating journey. A comparative analysis on the disciplinary history of performance art studies in the US and China laid a foundation in exploring the dynamics of marginality in two contexts. Extracting from the narrative mechanism and body view of Chinese performance art, I demonstrate how the philosophy of living (生) inspired many artistic creation, which also echoes my research journey. And from our mutual living experience, I pose the concept of constructive untranslatability that applies positionality and situated knowledge …

In The Words Of Early Adolescents: A Novel Assessment Of Positive Psychological Well-Being Predicts Young Adult Depressive Symptoms, Julia K. Boehm, Farah Qureshi, Laura D. Kubzansky

Psychology Faculty Articles and Research

Purpose

Methods

The Emotional Experience Of Representative Bureaucrats In A Contested Public Policy Environment, Shaun Damien Heckstall

Walden Dissertations and Doctoral Studies

No abstract provided.

Identification Of Candidate Dna Methylation Biomarkers Related To Alzheimer’S Disease Risk By Integrating Genome And Blood Methylome Data, Yanfa Sun, Jingjing Zhu, Yaohua Yang, Zichen Zhang, Hua Zhong, Guanghua Zeng, Dan Zhou, Richard S Nowakowski, Jirong Long, Chong Wu, Lang Wu

Faculty, Staff and Student Publications

Alzheimer disease (AD) is a common neurodegenerative disease with a late onset. It is critical to identify novel blood-based DNA methylation biomarkers to better understand the extent of the molecular pathways affected in AD. Two sets of blood DNA methylation genetic prediction models developed using different reference panels and modelling strategies were leveraged to evaluate associations of genetically predicted DNA methylation levels with AD risk in 111,326 (46,828 proxy) cases and 677,663 controls. A total of 1,168 cytosine-phosphate-guanine (CpG) sites showed a significant association with AD risk at a false discovery rate (FDR) < 0.05. Methylation levels of 196 CpG sites were correlated with expression levels of 130 adjacent genes in blood. Overall, 52 CpG sites of 32 genes showed consistent association directions for the methylation-gene expression-AD risk, including nine genes (CNIH4, THUMPD3, SERPINB9, MTUS1, CISD1, FRAT2, CCDC88B, FES, and SSH2) firstly reported as AD risk genes. Nine of 32 genes were enriched in dementia and AD disease categories (P values ranged from 1.85 × 10-4 to 7.46 × 10-6), and 19 genes in a neurological disease network (score = 54) were also observed. Our findings improve the understanding of genetics and etiology for AD.

Connecting With A Lost Heritage: The Indigenous Taino Community Of The Caribbean In New York City, Angeles R. Rodriguez Negron

Capstones

Among New York City's diasporic communities lie the Indigenous Tainos, an aboriginal people originally from the Caribbean region. But many people are unaware of their existence. There is a belief among Puerto Ricans and other Caribbean societies that the Tainos are an extinct tribe since the 16th century due to European colonization. The Taino revivalist movement has taken strength during the last 30 years, and more Taino descendants are taking pride on their identity and culture. After 5 months of collaboration with this Indigenous community, Puerto Rican journalist Ángeles Rodríguez Negrón created Miyari Taino, a podcast designed to provide visibility …

The Pima County Jail In A “State Of Full-Blown Crisis”: Inmate Deaths Four Times The National Average, Natalie Robbins

Capstones

Last year, 12 inmates died in custody at the Pima County Jail in Tucson, Arizona. With a 10-year average jail population of 1,827, that is a per capita rate of 656.8 deaths per 100,000 inmates.

According to the most recent data from the Bureau of Justice Statistics, the 2019 national local jail mortality rate was 167 deaths for every 100,000 inmates, making the Pima County Jail’s 2022 per capita death rate nearly four times as high as the national average in 2019.

In a December 2022 memo to the Pima County Board of Supervisors, Pima County Sheriff Chris Nanos wrote …

“Unsanitary, Rundown, Everything Is Broken”: The Reality Of Queer Homeless Shelters, Sunjum Nagpaul

Capstones

Despite the larger need for queer-designated shelters, there are only a handful of them out of hundreds of city shelters. Most of them are for youth except Marsha’s House, located in Belmont in the Bronx, which has an age limit of 30. It also comes with a slew of concerns, like staff who are unfamiliar with LGBTQ+ issues and a layout that can exclude those with physical disabilities. What’s more, queer residents face many of the same challenges others homeless do: dirty and unsanitary facilities that never seem to improve.

https://medium.com/@sunny.nagpaul/unsanitary-rundown-everything-is-broken-the-reality-of-homeless-shelters-fd2940f6b862

Documents From The December 13, 2023 Meeting Of The University Of Montana Staff Senate, University Of Montana--Missoula. Staff Senate

University of Montana Staff Senate Meeting Minutes

Agenda and meeting minutes from the December 13th 2023 meeting of the University of Montana Staff Senate.

Highlights include Secretary election and Presentation by VP for Information Technology and Chief Information Officer Zach Rossmiller.

Epigenomic Mapping Reveals Distinct B Cell Acute Lymphoblastic Leukemia Chromatin Architectures And Regulators, Kelly R Barnett, Robert J Mobley, Jonathan D Diedrich, Brennan P Bergeron, Kashi Raj Bhattarai, Alexander C Monovich, Shilpa Narina, Wenjian Yang, Kristine R Crews, Christopher S Manring, Elias Jabbour, Elisabeth Paietta, Mark R Litzow, Steven M Kornblau, Wendy Stock, Hiroto Inaba, Sima Jeha, Ching-Hon Pui, Charles G Mullighan, Mary V Relling, Shondra M Pruett-Miller, Russell J H Ryan, Jun J Yang, William E Evans, Daniel Savic

Faculty, Staff and Student Publications

B cell lineage acute lymphoblastic leukemia (B-ALL) is composed of diverse molecular subtypes, and while transcriptional and DNA methylation profiling has been extensively examined, the chromatin landscape is not well characterized for many subtypes. We therefore mapped chromatin accessibility using ATAC-seq in primary B-ALL cells from 156 patients spanning ten molecular subtypes and present this dataset as a resource. Differential chromatin accessibility and transcription factor (TF) footprint profiling were employed and identified B-ALL cell of origin, TF-target gene interactions enriched in B-ALL, and key TFs associated with accessible chromatin sites preferentially active in B-ALL. We further identified over 20% of …

Multidimensional Measures Of Militarization (M3): A Global Dataset, Markus Bayer, Aurel Croissant, Roya Izadi, Nikitas Scheeder

Political Science Faculty Publications

In this article, we present the novel M3dataset. This global dataset brings together 30 existing and newly developed indicators and a total of 140,000 observations on three dimensions of material, political, and societal militarization from 1990 to 2020. We introduce a novel, multidimensional concept of militarization, explain the construction of the dataset, data-collection process, and the measures taken to ensure the validity and reliability of the data. We illustrate the usefulness of the dataset for researchers by analyzing for the first time the impact of military policing as one aspect of societal militarization on violence and human rights violations at …

Matter Of Helm V. New York State Div. Of Hous. & Community Renewal

All Decisions

No abstract provided.

Behavioural Responses Of Fin Whales To Military Mid-Frequency Active Sonar, Brandon L. Southall, Ann N. Allen, John Calambokidis, Caroline Casey, Stacy L. Deruiter, Selene Fregosi, Ari S. Friedlaender, Jeremy A. Goldbogen, Catriona M. Harris, Elliott L. Hazen, Valentin Popov, Alison K. Stimpert

Faculty Research, Scholarly, and Creative Activity

The effect of active sonars on marine mammal behaviour is a topic of considerable interest and scientific investigation. Some whales, including the largest species (blue whales, Balaenoptera musculus), can be impacted by mid-frequency (1-10 kHz) military sonars. Here we apply complementary experimental methods to provide the first experimentally controlled measurements of behavioural responses to military sonar and similar stimuli for a related endangered species, fin whales (Balaenoptera physalus). Analytical methods include: (i) principal component analysis paired with generalized additive mixed models; (ii) hidden Markov models; and (iii) structured expert elicitation using response severity metrics. These approaches provide complementary perspectives on …

Decreased Fxr Agonism In The Bile Acid Pool Is Associated With Impaired Fxr Signaling In A Pig Model Of Pediatric Nafld, Magdalena A Maj, Douglas G Burrin, Rodrigo Manjarín

Faculty, Staff and Students Publications

The objective of this study was to investigate whether the impairment of farnesoid X receptor (FXR)-fibroblast growth factor 19 (FGF19) signaling in juvenile pigs with non-alcoholic fatty liver disease (NAFLD) is associated with changes in the composition of the enterohepatic bile acid pool. Eighteen 15-day-old Iberian pigs, pair-housed in pens, were allocated to receive either a control (CON) or high-fructose, high-fat (HFF) diet. Animals were euthanized in week 10, and liver, blood, and distal ileum (DI) samples were collected. HFF-fed pigs developed NAFLD and had decreased FGF19 expression in the DI and lower FGF19 levels in the blood. Compared with …

Towards An Efficient Machine Learning Based Phish Detection System, Hamad Alfalasi

Theses

Over the recent past, the world has experienced a digital revolution that has profoundly transformed many aspects of human life. This revolution has redefined the way individuals interact, how businesses operate, and how societies function. For businesses, operations have been fundamentally altered, changing the way they interact with customers and other businesses through digital tools and platforms used for transactions. Phishing, a deceitful approach, leverages technological and social tricks to access sensitive personal information, including financial details. A common attack mode involves installing harmful software on electronic devices to gain unauthorized access to personal information, particularly usernames and passwords of …

A System For Multi-Level, Multi-Variate Embedding Framework For Risk Scoring, Hao Xu, Anurag Tangri, Chiranjeet Chetia

Defensive Publications Series

The present disclosure provides a novel system for multi-level multi-variate embedding framework for risk scoring. In the present disclosure, risk factors within each category are aggregated as one score using Level-1 embedding, while a global risk score is obtained using Level-2 embedding. The framework models different scores considering the interactive effects among different factors and scores. Also, any auxiliary variables that are important for global risk scoring can be easily integrated. The coefficients in multi-level embedding can be determined within one process based on historical data of user interested activities. A penalized loss is used to optimize the model structure …

E-Governance: The Implication Of Next Social Generation Welfare Information System, Yaya Mulyana Abdul Aziz, Andre Ariesmansyah

Smart City

Accelerating bureaucracy can be performed by e-governance present in order to improve the quality of government administration in the world. E-governance draft is closely related to the development of information and communication technology (ICT) globally. One form of embodiment of e-governance is the implementation of a smart city. smart cities are expected to be able to become a liaison between the demands of the community in appropriate, effective, and efficient services from the city government, by utilizing ICT. There are various related definitions of smart city in this world. One of them is as explained by Nam and Pardo who …

Abortion In The Fiction Of Laclos, Rousseau, Isabelle De Charrière, Montesquieu, Servanne Woodward

ABO: Interactive Journal for Women in the Arts, 1640–1830

Eighteenth-century French fiction containing episodes on abortion are influenced by the seventeenth-century scandal of La Voisin, and by the 1731 legal suit involving the Jesuit Priest Père Girard and Catherine Cadière. Two observations may be derived from eighteenth-century French novels: women's abortions are monitored, instigated, and decided by fathers, husbands and lovers, who select for them, if they are to remain celibate, and whose children they bear. And as well, abortion tests or reveals the limits of a woman’s individual freedom and right to care for herself.

The Quick And The Dead (And The Transported), Manushag N. Powell

ABO: Interactive Journal for Women in the Arts, 1640–1830

In most nations that still execute prisoners—including the U.S.—it is illegal to execute a pregnant person. In English common law, women have been permitted to “plead the belly” in one form or another since the 14^th century, and this fact is sometimes misconstrued by anti-choice and forced-birth advocates as evidence of a long legal tradition of protection for the lives of fetuses. In fact, it is merely evidence of a long history of legal inconsistencies in the ways laws were applied and sentences carried out against women, for whom there were fewer options for clemency than for men. This …

Review Of Giving Birth In Eighteenth-Century England, By Sarah Fox, Chelsea Phillips

ABO: Interactive Journal for Women in the Arts, 1640–1830

A Review of Giving Birth in Eighteenth-Century England, by Sarah Fox

Review Of Sister Novelists, By Devoney Looser, Katherine Binhammer Prof.

ABO: Interactive Journal for Women in the Arts, 1640–1830

Review of Sister Novelists by Devoney Looser.

Teaching Anne Finch’S Satire In The British Literature Survey Classroom, Amanda Hiner

ABO: Interactive Journal for Women in the Arts, 1640–1830

This article argues for the intentional inclusion of Anne Finch’s diverse and compelling satires in the undergraduate British literature survey course and for the recognition of Finch as an accomplished theorist and practitioner of satire. The article includes practical strategies for pairing Finch’s satires with other well-known and anthologized satires; examines her satires in the context of the Revolution of 1688; and provides an analysis of her innovative rhetorical strategies, including her efforts to dissociate herself from satire while simultaneously producing sharp and defiant satires. The article argues that cultivating a deeper understanding of Finch’s contributions to eighteenth-century satire enriches …

Introduction: Concise Collection On Teaching The Works Of Anne Finch, Part One, Jennifer Keith

ABO: Interactive Journal for Women in the Arts, 1640–1830

This essay introduces Part One of the two-part “Concise Collection on Teaching the Works of Anne Finch," guest edited by Jennifer Keith (Aphra Behn Online, vol. 13, no. 2, 2023). The second part of this collection is scheduled for Spring 2024.

At A Glance, Wayne R. Petersen

Bird Observer

No abstract provided.

Letter To The Editor, Paul Baicich

Bird Observer

No abstract provided.

About Books: Birding In Full Battle-Rattle: A Conversation With Jonathan Trouern-Trend, Mark Lynch

Bird Observer

No abstract provided.