Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

Discipline
Institution
Keyword
Publication Year
Publication
Publication Type
File Type

Articles 110761 - 110790 of 1326687

Full-Text Articles in Entire DC Network

Mentoring Nurses After Specialty Training Or Orientation In Labor And Delivery, Benjamin Jlopleh Worji Dec 2023

Mentoring Nurses After Specialty Training Or Orientation In Labor And Delivery, Benjamin Jlopleh Worji

Master's Projects and Capstones

Mentoring Nurses After Specialty Training or Orientation in Labor and Delivery

Abstract

Background: The setting for this project was a northern California hospital-based healthcare system referred to as “Hospital KV.” Hospital KV is a non-profit, integrated hospital that operates to improve the community’s health. Hospital KV’s maternal child health (MCH) department comprises a labor and delivery(L&D) unit, a mother and baby unit (MBU), also referred to as a postpartum unit, and an intermediate nursery (IMN).

Problem: The hospital KV MCH department faced the challenge of a nursing shortage. The nursing shortage was associated with substantial challenges to Hospital KV, its …


Enhancing Diabetic Patient Continuous Glucose Monitoring Access, Colleen Ildefonso Dec 2023

Enhancing Diabetic Patient Continuous Glucose Monitoring Access, Colleen Ildefonso

Master's Projects and Capstones

Problem: Diabetic patients utilize treatments that require frequent monitoring and medication changes based on their blood sugar results. Continuous Glucose Monitoring (CGM) is more commonly used for diabetes management as time in range is becoming more prevalent to measure diabetes outcomes. Many diabetic patients find CGM use more accessible than finger sticks and glucometers. In contrast, others utilize the technology to closely monitor their blood sugars for interventions throughout the day. However, older adults have difficulty facilitating new CGM technology and may require further reinforcement using additional education methods such as teach-back.

Context: The endocrinology clinic serves a patient population, …


Reducing Care Companion Utilization In Medical-Surgical And Telemetry Units, Mary Jane B. Sagabaen Dec 2023

Reducing Care Companion Utilization In Medical-Surgical And Telemetry Units, Mary Jane B. Sagabaen

Master's Projects and Capstones

Abstract

Problem: The facility highly utilized sitters or care companions, negatively impacting the staffing plan, budget, and productivity. An average of 56 hours of care companions were used daily. This greatly exceeded the budget of 33 hours a day. Reassigning Patient Care Technicians (PCT) as care companions resulted in inadequate nurse support for patient care and increased cost for additional staffing needs. Despite this, the fall rate remained higher than the target.

Context: The patient population is mainly 65 years old and above, sometimes with confusion, dementia, delirium, and at high risk for falls and elopement. The culture included promptly …


Factors Affecting Adoption Of Tiktok Among Students In The Dhaka City Area., Mahafizur R. Jim, Muhammad I. Alam Dec 2023

Factors Affecting Adoption Of Tiktok Among Students In The Dhaka City Area., Mahafizur R. Jim, Muhammad I. Alam

Business Review

This study investigates the factors affecting adoption of TikTok among the students in Dhaka city area. A structured survey questionnaire was developed through the survey tool, Google form and data were obtained from 529 respondents living in various locations of Dhaka city by an online survey method through using the social media platform, Facebook. Moreover, the multiple regression analysis was performed to test the research hypotheses. Results show that students perceive this app in a different way and do not consider this app as a great source of enjoyment. Moreover, they do not perceive this app as a decent media …


Lemons And Other Grand Delusions, Jake A. Yarnold Dec 2023

Lemons And Other Grand Delusions, Jake A. Yarnold

Master's Theses

Lemons and Other Grand Delusions explores a host of characters as they come face to face with their greatest fears, as they get exactly what they think they want. From magic dimension-bending lemons, to automatons powered by the Philosopher’s Stone, as the powers from beyond become in-hand realities, the characters find their greatest desires are not as simple and powerful in their hands as they first thought. Exploring the limits of greed and desire within ourselves and in the society we live in, the collection asks who are we, if not a collection of our own desires, and the impulses …


From Margins To Museums: Tracing The Evolution Of Representation For Contemporary African Artists In The United States, Victoria Mouraux Durand-Ruel Dec 2023

From Margins To Museums: Tracing The Evolution Of Representation For Contemporary African Artists In The United States, Victoria Mouraux Durand-Ruel

Master's Theses

This thesis examines the impact of the Black Lives Matter movement on the art community in the United States and the evolution of representation for Contemporary African artists. By analyzing the careers and artistic contributions of Omar Ba, Toyin Ojih Odutola, and Njideka Akunyili Crosby, the study explores the concept of artistic agency according to which African artists have more control over the production and distribution of their works.

The research begins with a comprehensive literature review, investigating the historical contexts that have shaped the art landscape, including the impact of colonization, decolonization, and globalization. The study reveals how these …


Top Tips For Effective Use Of Periodontal Instruments In Primary Care, Morag Powell, Ruth Potterton, Ewen Mccoll Dec 2023

Top Tips For Effective Use Of Periodontal Instruments In Primary Care, Morag Powell, Ruth Potterton, Ewen Mccoll

Peninsula Dental School

Stabilisation of primary disease is a key pillar of successful treatment and in addition to managing caries, managing periodontal disease is a crucial component of a successful treatment plan. The recent European Federation of Periodontology (EFP) S3 level clinical practice guidelines (CPG)1 are evidence‐based clinical guidelines providing recommendations to treat periodontitis. Crucial to successful implementation of these recommendations is delivering behavioural change and non-surgical instrumentation. Often this is given passing attention with insufficient time allocated to behaviour change in treatment planning. Similarly, poorly maintained periodontal instruments and equipment not used to their full utility or design can lead to poorer …


Effect Of Temperature And Steam-To-Carbon Monoxide (Co) Ratio On Hydrogen Production In Water-Gas Shift Reaction Using Cu-Zno-Al2o3 Catalyst, Sekar Kumala Desi, Restu Siti Nursa'adah, Hana Nabila Anindita, Bambang Muharto, Nurdiah Rahmawati, Tyas Puspita Rini, Erlan Rosyadi Dec 2023

Effect Of Temperature And Steam-To-Carbon Monoxide (Co) Ratio On Hydrogen Production In Water-Gas Shift Reaction Using Cu-Zno-Al2o3 Catalyst, Sekar Kumala Desi, Restu Siti Nursa'adah, Hana Nabila Anindita, Bambang Muharto, Nurdiah Rahmawati, Tyas Puspita Rini, Erlan Rosyadi

Makara Journal of Science

This study investigates the effect of steam-to-CO molar ratio and temperature on hydrogen production in a water gas shift reaction using a Cu-ZnO-Al2O3 catalyst. Herein, different steam-to-CO molar ratios (1:1, 2:1, and 3:1) and temperatures (200 °C, 250 °C, and 300 °C) were applied to investigate their impact on the reaction and H2 production. The Cu-ZnO-Al2O3 catalyst was characterized by its surface area, pore size distribution, and chemical composition. Moreover, the experimental setup enabled the control of temperature and steam-to-CO molar ratio while monitoring the product gas composition. The results revealed a considerable …


Combining The Tyrosine Kinase Inhibitor Cabozantinib And The Mtorc1/2 Inhibitor Sapanisertib Blocks Erk Pathway Activity And Suppresses Tumor Growth In Renal Cell Carcinoma, Yige Wu, Siqi Chen, Xiaolu Yang, Kazuhito Sato, Preet Lal, Yuefan Wang, Andrew T Shinkle, Michael C Wendl, Tina M Primeau, Yanyan Zhao, Alanna Gould, Hua Sun, Jacqueline L Mudd, Jeremy Hoog, R Jay Mashl, Matthew A Wyczalkowski, Chia-Kuei Mo, Ruiyang Liu, John M Herndon, Sherri R Davies, Di Liu, Xi Ding, Yvonne A Evrard, Bryan E Welm, David Lum, Mei Yee Koh, Alana L Welm, Jeffrey H Chuang, Jeffrey A Moscow, Funda Meric-Bernstam, Ramaswamy Govindan, Shunqiang Li, James Hsieh, Ryan C Fields, Kian-Huat Lim, Cynthia X Ma, Hui Zhang, Li Ding, Feng Chen Dec 2023

Combining The Tyrosine Kinase Inhibitor Cabozantinib And The Mtorc1/2 Inhibitor Sapanisertib Blocks Erk Pathway Activity And Suppresses Tumor Growth In Renal Cell Carcinoma, Yige Wu, Siqi Chen, Xiaolu Yang, Kazuhito Sato, Preet Lal, Yuefan Wang, Andrew T Shinkle, Michael C Wendl, Tina M Primeau, Yanyan Zhao, Alanna Gould, Hua Sun, Jacqueline L Mudd, Jeremy Hoog, R Jay Mashl, Matthew A Wyczalkowski, Chia-Kuei Mo, Ruiyang Liu, John M Herndon, Sherri R Davies, Di Liu, Xi Ding, Yvonne A Evrard, Bryan E Welm, David Lum, Mei Yee Koh, Alana L Welm, Jeffrey H Chuang, Jeffrey A Moscow, Funda Meric-Bernstam, Ramaswamy Govindan, Shunqiang Li, James Hsieh, Ryan C Fields, Kian-Huat Lim, Cynthia X Ma, Hui Zhang, Li Ding, Feng Chen

Faculty, Staff and Student Publications

Current treatment approaches for renal cell carcinoma (RCC) face challenges in achieving durable tumor responses due to tumor heterogeneity and drug resistance. Combination therapies that leverage tumor molecular profiles could offer an avenue for enhancing treatment efficacy and addressing the limitations of current therapies. To identify effective strategies for treating RCC, we selected ten drugs guided by tumor biology to test in six RCC patient-derived xenograft (PDX) models. The multitargeted tyrosine kinase inhibitor (TKI) cabozantinib and mTORC1/2 inhibitor sapanisertib emerged as the most effective drugs, particularly when combined. The combination demonstrated favorable tolerability and inhibited tumor growth or induced tumor …


Early Diagnosis Methods For Autism Spectrum Disorder: A Systematic Review, Megan Denise Mccarthy Dec 2023

Early Diagnosis Methods For Autism Spectrum Disorder: A Systematic Review, Megan Denise Mccarthy

Doctoral Dissertations

Objective: This systematic review aimed to comprehensively synthesize existing literature on early detection methods for Autism Spectrum Disorder (ASD) in children birth to 3 years, that lead to an effective and reliable early diagnosis in children 2 to 3 years of age.

Methods: A systematic search was conducted across multiple electronic databases, including PubMed, Scopus, and PsycINFO following PRISMA guidelines. Studies reporting on early detection methods for ASD in infants and toddlers within ages 0 to 3 years that lead to early diagnosis of children ages 2 to 3 years were eligible for inclusion. Data extraction and quality assessment were …


T1 And Flair Signal Intensities Are Related To Tau Pathology In Dominantly Inherited Alzheimer Disease, Farzaneh Rahmani, Matthew R Brier, Brian A Gordon, Nicole Mckay, Shaney Flores, Sarah Keefe, Russ Hornbeck, Beau Ances, Nelly Joseph-Mathurin, Chengjie Xiong, Guoqiao Wang, Cyrus A Raji, Jorge J Libre-Guerra, Richard J Perrin, Eric Mcdade, Alisha Daniels, Celeste Karch, John C Morris, Randall J Bateman, Tammie L S Benzinger, Et Al. Dec 2023

T1 And Flair Signal Intensities Are Related To Tau Pathology In Dominantly Inherited Alzheimer Disease, Farzaneh Rahmani, Matthew R Brier, Brian A Gordon, Nicole Mckay, Shaney Flores, Sarah Keefe, Russ Hornbeck, Beau Ances, Nelly Joseph-Mathurin, Chengjie Xiong, Guoqiao Wang, Cyrus A Raji, Jorge J Libre-Guerra, Richard J Perrin, Eric Mcdade, Alisha Daniels, Celeste Karch, John C Morris, Randall J Bateman, Tammie L S Benzinger, Et Al.

2020-Current year OA Pubs

Carriers of mutations responsible for dominantly inherited Alzheimer disease provide a unique opportunity to study potential imaging biomarkers. Biomarkers based on routinely acquired clinical MR images, could supplement the extant invasive or logistically challenging) biomarker studies. We used 1104 longitudinal MR, 324 amyloid beta, and 87 tau positron emission tomography imaging sessions from 525 participants enrolled in the Dominantly Inherited Alzheimer Network Observational Study to extract novel imaging metrics representing the mean (μ) and standard deviation (σ) of standardized image intensities of T1-weighted and Fluid attenuated inversion recovery (FLAIR) MR scans. There was an exponential decrease in FLAIR-μ in mutation …


A Novel Application Of The Coras Framework For Ensuring Cyber Hygiene On Shipboard Radar, Gizem Kayisoglu, Pelin Bolat, Kimberly Tam Dec 2023

A Novel Application Of The Coras Framework For Ensuring Cyber Hygiene On Shipboard Radar, Gizem Kayisoglu, Pelin Bolat, Kimberly Tam

School of Engineering, Computing and Mathematics

No abstract provided.


Middle-Earth, Or There And Back Again, Edited By Łukasz Neubauer. Reviewed By Hamish Williams., Hamish Williams Dec 2023

Middle-Earth, Or There And Back Again, Edited By Łukasz Neubauer. Reviewed By Hamish Williams., Hamish Williams

Mythprint Book Reviews

Mythprint is the quarterly bulletin of the Mythopoeic Society, a nonprofit educational organization devoted to the study, discussion, and enjoyment of myth and fantasy literature, especially the works of J.R.R. Tolkien, C.S. Lewis, and Charles Williams. To promote these interests, the Society publishes three magazines, maintains a World Wide Web site, and sponsors the annual Mythopoeic Conference and awards for fiction and scholarship, as well as local discussion groups.


Galonsky V. East 17th Llc Dec 2023

Galonsky V. East 17th Llc

All Decisions

No abstract provided.


Unsupervised Multi-Resolution Analysis Of Protein-Protein Abundance Patterns In Infectious Exacerbation Of Copd, Eric Everingham Dec 2023

Unsupervised Multi-Resolution Analysis Of Protein-Protein Abundance Patterns In Infectious Exacerbation Of Copd, Eric Everingham

Theses

Despite consistently appearing as a top 5 cause of death domestically and internationally, understandings of the underlying biological interactions of COPD remain insufficient. Particularly, early identification of highly vulnerable patients that may experience more severe infectious exacerbation is a challenge during diagnostics. This project leverages unsupervised clustering and multi-resolution decomposition of proteomic abundance profiles in a small cohort of COPD subjects to identify candidate biomarkers of heightened exacerbation risk. As part of an ongoing study, serum and sputum samples were collected during well visits (stable illness) from n=67 subjects, and analyzed using quantitative proteomics. A scores principal component analysis was …


Performance Evaluation Of Residential Design In Four Different Climate Zones Using Passive House Strategies And Metrics, Ian Luhmann Dec 2023

Performance Evaluation Of Residential Design In Four Different Climate Zones Using Passive House Strategies And Metrics, Ian Luhmann

Theses

This study presents a comprehensive performance evaluation of residential designs across four different climate zones, employing Passive House strategies and metrics to achieve energy efficiency, comfort, and sustainability. The Passive House standard, recognized for its rigorous approach to energy-efficient buildings, is the cornerstone of this research. The objective is to adapt and optimize residential designs to meet the specific climate conditions of each zone while adhering to the Passive House principles and noting the modifications necessary to do so.


Enrichment-Planting With Pines Alters Fuel Amount And Structure In Endangered Araucaria Araucana Forests In Northwestern Patagonia, Argentina, Sofia Cingolani, Ignacio A. Mundo, Ivan Barbera, Andrés Holz, Thomas T. Veblen, Juan Paritsis Dec 2023

Enrichment-Planting With Pines Alters Fuel Amount And Structure In Endangered Araucaria Araucana Forests In Northwestern Patagonia, Argentina, Sofia Cingolani, Ignacio A. Mundo, Ivan Barbera, Andrés Holz, Thomas T. Veblen, Juan Paritsis

Geography Faculty Publications and Presentations

The introduction of non-native tree species for large-scale afforestation may alter the fire regime of native ecosystems by modifying fuel proprieties. We quantified changes in fuel abundance and structure resulting from the establishment of commercial Pinus spp. plantations in Araucaria araucana ecosystems in northwestern Patagonia, Argentina. Specifically, we assessed the amount, distribution, and condition (live/dead) of surface and standing fine fuel in A. araucana stands with mature pine plantations (i.e. > 20 cm dbh) and in stands dominated only by A. araucana (control). Our study shows that both types of stands are prone to wildfires, but pine plantations have fuel characteristics …


American Institution Of Public, K-12 Education: An Institutional Field Under A Complexity Paradigm, Jennifer Jean Joyalle Dec 2023

American Institution Of Public, K-12 Education: An Institutional Field Under A Complexity Paradigm, Jennifer Jean Joyalle

Dissertations and Theses

Institutional fields serve as foundational bedrocks that shape and govern behaviors, norms, and practices within distinct domains of societal and organizational interactions. The emergence of machine learning and the ability to manipulate large datasets offer researchers and decision makers the potential ability to model and visualize the behavior associated with institutional fields.

This proof of concept provides an example of visualizing the changing conditions in the institutional field of public K-12 education in America as a topology. By interweaving three primary strands of theory -- institutional fields, complexity in the guise of complex adaptive systems as a paradigm, and paradigms …


Lilrb3 Modulates Acute Myeloid Leukemia Progression And Acts As An Effective Target For Car T-Cell Therapy, Sunny Mai, Alan Hodges, Hui-Ming Chen, Jilu Zhang, Yi-Ling Wang, Yongbin Liu, Fumiko Nakatsu, Xiaoxuan Wang, Jing Fang, Yitian Xu, Vitaliy Davidov, Kyeongah Kang, Sai Ravi Pingali, Siddhartha Ganguly, Masataka Suzuki, Marina Konopleva, Brooke Prinzing, Youli Zu, Stephen Gottschalk, Yong Lu, Shu-Hsia Chen, Ping-Ying Pan Dec 2023

Lilrb3 Modulates Acute Myeloid Leukemia Progression And Acts As An Effective Target For Car T-Cell Therapy, Sunny Mai, Alan Hodges, Hui-Ming Chen, Jilu Zhang, Yi-Ling Wang, Yongbin Liu, Fumiko Nakatsu, Xiaoxuan Wang, Jing Fang, Yitian Xu, Vitaliy Davidov, Kyeongah Kang, Sai Ravi Pingali, Siddhartha Ganguly, Masataka Suzuki, Marina Konopleva, Brooke Prinzing, Youli Zu, Stephen Gottschalk, Yong Lu, Shu-Hsia Chen, Ping-Ying Pan

Faculty, Staff and Students Publications

Identifying novel cell surface receptors that regulate leukemia cell differentiation and can be targeted to inhibit cellular proliferation is crucial to improve current treatment modalities in acute myeloid leukemia (AML), especially for relapsed or chemotherapy-refractory leukemia. Leukocyte immunoglobulin-like receptor type B (LILRB) is an immunomodulatory receptor originally found to be expressed in myeloid cells. In this study, we found that LILRB receptors can be induced under inflammatory stimuli and chemotherapy treatment conditions. Blockade of LILRB3 inhibited leukemia cell proliferation and leukemia progression. Additionally, treatment with LILRB3 blocking antibodies upregulated myeloid lineage differentiation transcription factors, including PU.1, C/EBP family, and IRF, …


Enniatin A Inhibits The Chaperone Hsp90 And Unleashes The Immune System Against Triple-Negative Breast Cancer, Nada H Eisa, Vincent M Crowley, Asif Elahi, Vamsi Krishna Kommalapati, Michael A Serwetnyk, Taoufik Llbiyi, Sumin Lu, Kashish Kainth, Yasmeen Jilani, Daniela Marasco, Abdeljabar El Andaloussi, Sukyeong Lee, Francis T F Tsai, Paulo C Rodriguez, David Munn, Esteban Celis, Hasan Korkaya, Abdessamad Debbab, Brian Blagg, Ahmed Chadli Dec 2023

Enniatin A Inhibits The Chaperone Hsp90 And Unleashes The Immune System Against Triple-Negative Breast Cancer, Nada H Eisa, Vincent M Crowley, Asif Elahi, Vamsi Krishna Kommalapati, Michael A Serwetnyk, Taoufik Llbiyi, Sumin Lu, Kashish Kainth, Yasmeen Jilani, Daniela Marasco, Abdeljabar El Andaloussi, Sukyeong Lee, Francis T F Tsai, Paulo C Rodriguez, David Munn, Esteban Celis, Hasan Korkaya, Abdessamad Debbab, Brian Blagg, Ahmed Chadli

Faculty, Staff and Students Publications

Low response rates and immune-related adverse events limit the remarkable impact of cancer immunotherapy. To improve clinical outcomes, preclinical studies have shown that combining immunotherapies with N-terminal Hsp90 inhibitors resulted in improved efficacy, even though induction of an extensive heat shock response (HSR) and less than optimal dosing of these inhibitors limited their clinical efficacy as monotherapies. We discovered that the natural product Enniatin A (EnnA) targets Hsp90 and destabilizes its client oncoproteins without inducing an HSR. EnnA triggers immunogenic cell death in triple-negative breast cancer (TNBC) syngeneic mouse models and exhibits superior antitumor activity compared to Hsp90 N-terminal inhibitors. …


Timigp: An R Package To Depict The Tumor Microenvironment From Bulk Transcriptomics, Chenyang Li, Jianjun Zhang, Chao Cheng Dec 2023

Timigp: An R Package To Depict The Tumor Microenvironment From Bulk Transcriptomics, Chenyang Li, Jianjun Zhang, Chao Cheng

Faculty, Staff and Students Publications

Exploring the clinical relevance of diverse immune cell types within the tumor microenvironment is pivotal for unraveling cancer intricacies and developing treatments. Here, we present a protocol for using tumor immune microenvironment illustration based on gene pairs, an R package to deduce cell-cell interactions, unveiling the association between immune cell relative abundance and patient prognoses from bulk gene expression and survival data. We describe steps for harnessing cell-type markers derived from single-cell RNA sequencing data to map the tumor immune microenvironment across a spectrum of cancer types. For complete details on the use and execution of this protocol, please refer …


Diversity And Dissemination Of Viruses In Pathogenic Protozoa, Senne Heeren, Ilse Maes, Mandy Sanders, Lon-Fye Lye, Vanessa Adaui, Jorge Arevalo, Alejandro Llanos-Cuentas, Lineth Garcia, Philippe Lemey, Stephen M Beverley, James A Cotton, Jean-Claude Dujardin, Frederik Van Den Broeck Dec 2023

Diversity And Dissemination Of Viruses In Pathogenic Protozoa, Senne Heeren, Ilse Maes, Mandy Sanders, Lon-Fye Lye, Vanessa Adaui, Jorge Arevalo, Alejandro Llanos-Cuentas, Lineth Garcia, Philippe Lemey, Stephen M Beverley, James A Cotton, Jean-Claude Dujardin, Frederik Van Den Broeck

2020-Current year OA Pubs

Viruses are the most abundant biological entities on Earth and play a significant role in the evolution of many organisms and ecosystems. In pathogenic protozoa, the presence of viruses has been linked to an increased risk of treatment failure and severe clinical outcome. Here, we studied the molecular epidemiology of the zoonotic disease cutaneous leishmaniasis in Peru and Bolivia through a joint evolutionary analysis of Leishmania braziliensis and their dsRNA Leishmania virus 1. We show that parasite populations circulate in tropical rainforests and are associated with single viral lineages that appear in low prevalence. In contrast, groups of hybrid parasites …


Combining The Tyrosine Kinase Inhibitor Cabozantinib And The Mtorc1/2 Inhibitor Sapanisertib Blocks Erk Pathway Activity And Suppresses Tumor Growth In Renal Cell Carcinoma, Yige Wu, Siqi Chen, Xiaolu Yang, Kazuhito Sato, Preet Lal, Andrew T Shinkle, Michael C Wendl, Tina M Primeau, Yanyan Zhao, Alanna Gould, Hua Sun, Jacqueline L Mudd, Jeremy Hoog, R Jay Mashl, Matthew A Wyczalkowski, Chia-Kuei Mo, Ruiyang Liu, John M Herndon, Sherri R Davies, Di Liu, Xi Ding, Ramaswamy Govindan, Shunqiang Li, James Hsieh, Ryan C Fields, Kian-Huat Lim, Cynthia X Ma, Li Ding, Feng Chen, Et Al. Dec 2023

Combining The Tyrosine Kinase Inhibitor Cabozantinib And The Mtorc1/2 Inhibitor Sapanisertib Blocks Erk Pathway Activity And Suppresses Tumor Growth In Renal Cell Carcinoma, Yige Wu, Siqi Chen, Xiaolu Yang, Kazuhito Sato, Preet Lal, Andrew T Shinkle, Michael C Wendl, Tina M Primeau, Yanyan Zhao, Alanna Gould, Hua Sun, Jacqueline L Mudd, Jeremy Hoog, R Jay Mashl, Matthew A Wyczalkowski, Chia-Kuei Mo, Ruiyang Liu, John M Herndon, Sherri R Davies, Di Liu, Xi Ding, Ramaswamy Govindan, Shunqiang Li, James Hsieh, Ryan C Fields, Kian-Huat Lim, Cynthia X Ma, Li Ding, Feng Chen, Et Al.

2020-Current year OA Pubs

UNLABELLED: Current treatment approaches for renal cell carcinoma (RCC) face challenges in achieving durable tumor responses due to tumor heterogeneity and drug resistance. Combination therapies that leverage tumor molecular profiles could offer an avenue for enhancing treatment efficacy and addressing the limitations of current therapies. To identify effective strategies for treating RCC, we selected ten drugs guided by tumor biology to test in six RCC patient-derived xenograft (PDX) models. The multitargeted tyrosine kinase inhibitor (TKI) cabozantinib and mTORC1/2 inhibitor sapanisertib emerged as the most effective drugs, particularly when combined. The combination demonstrated favorable tolerability and inhibited tumor growth or induced …


The Effect Of Bilingualism On Cognitive Development In Children Review Article, Amal Mahmoud Ali Dec 2023

The Effect Of Bilingualism On Cognitive Development In Children Review Article, Amal Mahmoud Ali

Alustath Journal for Human and Social Sciences

Bilingualism has become an increasingly common phenomenon in today’s globalized world, with many children growing up exposed to two or more languages. As a result, there has been growing interest among researchers in understanding the impact of bilingualism on thinking development in young and children. Some studies confirmed that bilingualism can have a positive effect on children’s perception cognitive development, particularly in the zones of attention control, Operational memory, and cognitive flexibility. Dual-language learners may also have better Planning and organization skills, such as task-switching and inhibitory control, compared to monolingual children. These cognitive advantages may be due to the …


Field Notes: Leucistic Female Boat-Tailed Grackle, William E. Davis Jr. Dec 2023

Field Notes: Leucistic Female Boat-Tailed Grackle, William E. Davis Jr.

Bird Observer

No abstract provided.


Thomas Nuttall: Pioneering Naturalist (1786-1859), John R. Nelson Dec 2023

Thomas Nuttall: Pioneering Naturalist (1786-1859), John R. Nelson

Bird Observer

No abstract provided.


Nineteenth Report Of The Massachusetts Avian Records Committee, Matthew P. Garvey, Jeremiah R. Trimble, Marshall J. Iliff Dec 2023

Nineteenth Report Of The Massachusetts Avian Records Committee, Matthew P. Garvey, Jeremiah R. Trimble, Marshall J. Iliff

Bird Observer

No abstract provided.


Gleanings: Getting From Point A To Point B, David M. Larson Dec 2023

Gleanings: Getting From Point A To Point B, David M. Larson

Bird Observer

No abstract provided.


Musings From The Blind Birder: Birding Paraphernalia, Martha Steele Dec 2023

Musings From The Blind Birder: Birding Paraphernalia, Martha Steele

Bird Observer

No abstract provided.


Musings From The Blind Birder: Birding Vocabulary, Martha Steele Dec 2023

Musings From The Blind Birder: Birding Vocabulary, Martha Steele

Bird Observer

No abstract provided.