Digital Commons Network^™

Computational Study Of The Effect Of Geometry On Molecular Interactions, Sarika Kumar

Computer Science ETDs

The specificity and predictability of DNA make it an excellent programmable material and have allowed bio-programmers to build sophisticated molecular circuits. These molecular devices should be precise, correct, and function as intended. In order to implement these circuits, the challenge is to build a robust, reliable, and scalable logic circuit with ideally minimum unwanted signal release. Performing experiments are expensive and time-consuming, so modeling and analyzing these bio-molecular systems become crucial in designing molecular circuits. This dissertation aimed to develop algorithms and build computational tools for automated analysis of molecular circuits that incorporate the molecular geometry of nanostructures. Molecular circuits …

The Art Of Sustaining Orchestras Through Intentional Educational Experiences, Kimberly Souther

Dissertations, 2020-current

The purpose of this study is to identify the most current and successful advances in audience engagement that champion connection and result in sustainability through purposeful educational experiences.

The Symphony Orchestra currently serves an audience which represents a multiplicity of perspectives, background, and understanding. In an era of expanded canon and outreach to local communities, the orchestra must acknowledge that change is necessary if we are to truly create fulfilling experiences for our listeners. Unfortunately, many orchestras fail to connect their outreach to the concert hall, woefully categorizing their patrons into pre-determined subsets. What if all patrons were trusted with …

Camargo Guarnieri's Twenty Estudos: A Commitment To Brazilian Nationalism And Virtuosity, Steven Brancaleone

Dissertations, 2020-current

This document aims to find how composer Camargo Guarnieri uses Brazilian trends and incorporates them into his individual style, specifically in his Twenty Estudos for piano. The long compositional period of these pieces displays frequent experimentation and maturation in Guarnieri’s style between 1949 and 1988. The trends that Guarnieri follow can be traced by examining his life, environment, and teachings. Brazilian figure and instructor, Mario de Andrade, also contributes to molding and refining Guarnieri’s ideas. With this study, the Twenty Estudos will display Guarnieri’s individualistic use of Brazilian trends and how they correlate to his mature compositional style.

Distinguishing High-Quality Audio: The Unique Contribution Of Bit-Depth Resolution?, Benjamin Stone

Masters Theses, 2020-current

Individuals are capable of discerning high- and low-quality digital audio, but the current evidence tends to confound sampling rate and bit depth (see Mizumachi et al., 2014). When bit-depth is constant, higher sampling rates can be discerned (Oohashi et al., 2000). It likewise has been argued that 16- and 24-bit audio can be distinguished when sampling rate is constant (Kanetada et al., 2013). The present study aimed to evaluate bit-depth-related perceptual ability using simplified tone stimuli in order to determine at which point from 8- to 24-bit that further increases in bit-depth resolution are no longer perceptually beneficial. Potential contributions …

Neurobehavioral And Eeg Characteristics In Latino Targets Of Bullying, Isabel Solis

Psychology ETDs

Bullying adversely impacts the well-being and development of youth, calling for a comprehensive understanding of its neurobehavioral and social mechanisms for targeted interventions. Despite the increasing demographic of Latino children, little is known about their early life experiences and individual traits that leave them susceptible to becoming targets of bullying. The present study utilized a mixed-methods design to address this gap, incorporating interviews, neuropsychological assessments, and resting-state EEG (rsEEG) spectral power within the alpha (8-13Hz) and theta (4-7Hz) frequency bands. The aim was to compare the cognitive, emotional, social, and neural characteristics of nine Latino Targets (LT) of bullying and …

Volumetric Imaging Using The Pupil-Matched Remote Focusing Technique In Light-Sheet Microscopy, Sayed Hassan Dibaji Foroushani

Optical Science and Engineering ETDs

ABSTRACT

The dissertation explores innovative techniques in light sheet microscopy, a pivotal tool in biomedical imaging, to enhance its speed, resolution, and efficiency in capturing dynamic biological processes. Light sheet microscopy allows for quick 3D imaging of biological specimens ranging from cells to organs with high spatiotemporal resolution, large field-of-view, and minimal damage, making it vital for in vivo imaging.

The first project introduces a novel optical concept designed to optimize Axially Swept Light Sheet Microscopy (ASLM). This technique is crucial for imaging specimens ranging from live cells to chemically cleared organs due to its versatility across different immersion media. …

Modeling Lithographic Quantum Dots And Donors For Quantum Computation And Simulation, Mitchell Ian Brickson

Physics & Astronomy ETDs

Our first focus is on few-hole quantum dots in germanium. We use discontinous Galerkin methods to discretize and solve the equations of a highly detailed k·p model that describes these systems, enabling a better understanding of experimental magnetospectroscopy results. We confirm the expected anisotropy of single-hole g-factors and describe mechanisms by which different orbital states have different g-factors. Building on this, we show that the g-factors in Ge holes are suciently sensitive to details of the device electrostatics that magnetospectroscopy data can be used to make a prediction of the underlying confinement potential. The second focus is on designing quantum …

An Interdisciplinary Education And Service Bundle To Reduce Hospital Resource Utilization And Decrease Pediatric Asthma-Related Morbidity And Mortality, Emily Yates

Seton Hall University Dissertations and Theses (ETDs)

The purpose of this quality improvement project was to reduce hospital resource utilization and improve health outcomes for children with asthma by providing an evidence-based, interdisciplinary education and service bundle to patients and families admitted to a Children’s Hospital in Northern New Jersey with a primary diagnosis of asthma. The 2020 Asthma Management Guidelines published by the U.S. Department of Health and Human Services (2020), the Global Initiative for Asthma (GINA) and a modified systematic review identified common themes among children at risk for asthma-related morbidity and mortality and high hospital resource utilization. These themes included medication misuse, asthma trigger …

Exploring The Use Of Time Delay As A Pragmatic Cue In Text Messaging, Nicklas Phillips

Masters Theses, 2020-current

Text messaging is often used as a stand-in for face to face communication. While texting mimics the rapid back and forth, turn taking nature of oral conversation, it lacks many of the pragmatic cues conversationalists ordinarily rely on to establish common ground and inform their understanding of sometimes nonliteral meaning conveyed to them. To get around this hurdle, texters have developed sets of textisms. These are specific cues that can be used to make up for the lack of pragmatic information in the texting environment. Examples include emoji, emoticons, and punctuation. This is an experimental study exploring whether time can …

Increasing Medication Adherence In Patients With Bipolar Disorder Using Mobile App Reminder, Emmaculate Ndifor

Doctors of Nursing Practice (DNP) Final Projects, 2020-current

Background: Bipolar disorder (BD) is the fifth leading course of disability in the world, contributing to many co-morbid conditions and complications. Non-adherence to medication is prevalent in patients with BD. The aim of the project was to use an evidence-based technological intervention to enhance medication adherence in BD patients between 18- 65 years old at an outpatient behavioral health clinic.

Methods: Baseline assessment included a pre Morisky Medication Adherence (MMAS-4) questionnaire. The development of an intervention to improve medication adherence was based on Johnson’s (2002) Medication Adherence Model (MAM).

Interventions: Participants downloaded the Medisafe app, registered medications and set …

Sexually Transmitted Infection Prevalence In College Students With Urinary Tract Infection Symptoms: A Pilot Study, Kathleen Beigh

Doctors of Nursing Practice (DNP) Final Projects, 2020-current

Approximately one in five individuals in the United States has had a sexually transmitted infection (STI). Individuals between 15 to 24 years are considered a ‘higher risk’ for developing new STIs than other age groups. Many STIs are treatable but difficult to detect and carry significant health implications. Chlamydia and gonorrhea can be treated effectively with antibiotics if detected early. STIs are challenging to diagnose due to having few or no symptoms and often go undetected and untreated. A specific concern related to STIs is misdiagnosis as a lower urinary tract infection (LUTI) only in persons born with a vagina …

Improvement Of Medication Compliance By Adding A Weekly Medication Planner, Jeramie Muya Laurio

Master's Projects and Capstones

Abstract

This quality improvement project aimed to use a weekly medication planner to enhance medication adherence in a home health setting to help improve patient healthcare outcomes. A weekly medication planner helps patients manage their medications. Systematic reviews and meta-analyses show medication planners increase adherence. Morisky 4-item survey assessed patient opinions pre and post intervention.

Problem:. Medication adherence is an important part of home health patient care that affects health outcomes and safety. The problem is patients received an abundance of discharge medications and do not have enough time with a Registered Nurse discharge planner to go over their …

A Bio-Inspired Alternative Positioning, Navigation, And Timing Approach Based On A Potential Game-Theoretic Model, Md Sadman Siraj

Electrical and Computer Engineering ETDs

This thesis addresses the challenge of designing of alternative Positioning, Navigation, and Timing (PNT) solutions. Inspired by the evolution of biological ecosystems, we introduce a novel symbiotic PNT solution, based on the principles of Game Theory and the exploitation of Reconfigurable Intelligent Surfaces (RISs). A set of actors, consisting of anchor nodes and RISs with known coordinates, collaborator nodes having a rough estimate of their positions, and targets of unknown positions, are cooperating to accurately determine the targets’ positioning and timing. The key objective is to minimize the estimation error of each target and collaborator node, as well as of …

Heat & Social Cooperation: The Effects Of Thermal Stress On Altruism, Alexander J. Courtman

Master's Theses

Recent literature has highlighted the effects of temperature on economic outcomes and violence in humans, on both the interpersonal and intergroup levels: as temperatures rise, humans are more likely to exhibit increased aggression and agitation. However, little research has been done on how pro-social behaviors like cooperation and altruism among humans might respond to increased temperatures. As extreme heat events increase in frequency, will humans and communities work together in the face of adverse shocks and crises? Leveraging experimental data collected randomized controlled trails held in 4 locations across the world, this paper seeks to establish a relationship between thermal …

Scott, Sue Title Ix Interview, Debbie Touatelli

General Athletics

Sue Scott was the Women’s Athletic Director at American River College. The first part of the recording is the radio interview with Scott by Debbie [Touatelli], the second part is radio commentary on women's volleyball attendance vs. football by Gail Schramm of KUOP.

Parsons, Edgar Athletics Oral History, Cindy Spiro

General Athletics

Ed Parsons was a 1934 graduated of Pacific and athlete

Digital Journeys: A Narrative Inquiry Into The Experiences Of Third- Grade Through Fifth-Grade General Education Teachers Implementing Instructional Technology In Northern California, Erin Layng

Doctor of Education Program Dissertations

The problem studied was the utilization of instructional technology in elementary classrooms, from third-grade through fifth-grade, and how teachers experience the use of technology in teaching methods and student learning. The purpose of this qualitative narrative inquiry was to understand the experiences of third-grade through fifth-grade teachers regarding the implementation of instructional technology in their classrooms. The study's timing captured teachers' views on technology before, during, and after the 2020-2021 academic year, which was heavily impacted by the COVID-19 pandemic and distance learning. Qualitative narrative inquiry allowed for a rich exploration of the teachers' experiences, with results of the study …

Socially Engaged Engineering: A Framework For K-8 Education, Christine M. Cunningham, Gregory J. Kelly, Ashwin Mohan

Journal of Pre-College Engineering Education Research (J-PEER)

Socially engaged engineering provides for student learning of the design, analysis, and practices of engineering as well as the ways that engineering is situated in sociocultural contexts. This paper provides a conceptual framework regarding socially engaged engineering for K-8 educators, researchers, and curriculum designers. The framework identifies ways to support youth learning of engineering and considerations of technical, social, environmental, and ethical dimensions of engineering. As engineering enters K-8 educational settings, it is important to introduce the discipline in equity-oriented ways. We draw from the field of engineering for social justice to build this framework for examining engineering at the …

A Preliminary Study On Floating Flexible Otec Cold Water Pipe, Nai Kuang Liang, Hai Kuan Peng

Journal of Marine Science and Technology–Taiwan

Ocean Thermal Energy Conversion (OTEC) requires a large amount of cold seawater. The traditional rigid pipe, semi-rigidly fixed onto the ship bottom is not easy to install and disassemble, so the Floating Flexible Cold Water Pipe (FFCWP) flexibly connected to the ship is proposed. A small FFCWP was designed, fabricated, and successfully installed and recovered in the sea. The flexible pipe adopts commercially available fire ventilation snake pipe. The pipe wall material strength must be improved in the future. Assuming that the drag coefficient Cd value is 1.5, a numerical calculation is employed to simulate the FFCWP attitude from the …

Machine Learning With Multi-Source Data To Predict And Explain Marine Pilot Occupational Accidents, Gokhan Camliyurt, Youngsoo Park, Daewon Kim, Won Sik Kang, Sangwon Park

Journal of Marine Science and Technology–Taiwan

Marine pilot occupational accidents during transfer to/from ships are the primary concern of the International Marine Pilots’ Association (IMPA) and industry professionals. There are multiple transfer methods for marine pilots, with the most common being the pilot boat. To reach the mother ship bridge, the following stages must be safely completed: car transfer, walking on the pier, pier to pilot boat, pilot transfer by boat, cutter to pilot ladder, mother ship freeboard climbing, and ship deck to the bridge. Each stage has its own risk. Previous accident records and expert opinions are commonly used to conduct a risk analysis and …

A Neuromuscular Training Program Performed On Foam Is Accompanied By Improved Balance And Jump Height In Recreational Runners, Katie L. Nixon, Cameron J. Franz, Carson J. Birchmeier, Jeremy L. Knous, David C. Berry, Kisha M. Osterhoff, Merrick A. Lincoln

Internet Journal of Allied Health Sciences and Practice

Purpose: To assess balance, plyometric performance, and strength of recreational runners completing a neuromuscular training (NMT) program on a novel foam surface. Methods: After baseline testing, participants (n=14) completed 22-minute exercise sessions on foam twice weekly for eight weeks, and a post-training testing battery. Testing included lower quarter Y-balance test (LQYBT), dynamic leap and balance test (DLBT), squat jump and countermovement jump tests, and isometric strength testing of the foot and ankle via handheld dynamometry (HHD). Participants were asked to maintain their normal running routines throughout the study period and report any training missed due to injury. Results: Participants demonstrated …

Remote Teleassessment And Telerehabilitation Of A Comprehensive Exercise Training Protocol For Older Adults: Design And Methodology Of A Usability Protocol, Savitha Subramaniam, Spyros Kitsiou, Tanvi Bhatt

Internet Journal of Allied Health Sciences and Practice

ABSTRACT

Purpose: The design, usability, safety, and feasibility of a telehealth protocol comprising teleassessment and tele rehabilitation to evaluate and improve physical and cognitive function among older adults was assessed. Methods: Healthy older adults (n=23) participated in a pre-post tele-assessment of a 4-week (3 sessions/week) telerehabilitation session. Tele-assessment was performed to evaluate balance, gait function, and cognition. Tele-rehabilitation sessions comprised of balance games, dancing, dual-tasking, yoga, and tai-chi exercises. Results: There were no adverse events reported to indicate concerns with the safety of the current telehealth protocol. Conclusion: The proposed telehealth protocol to assess and improve physical and cognitive function …

Student Athletic Therapists' Knowledge Of Pain-Relieving Medications: A Nationwide Study, Jackie Vandertuin, Dalya Abdulla, Stephanie Lowther, Joshua Collins

Internet Journal of Allied Health Sciences and Practice

Purpose: Misuse of pain-relieving medications (PRMs), including opioids, is high among injured athletes. Athletes are increasingly relying on PRMs and as a result, it is likely that student athletic therapists (SATs) have managed athletes who have misused PRMs and may have potentially missed important symptoms placing athletes in harm. While dispensing PRMs is not within the scope of practice of the SAT, recognition and referral are. Previous research has found that SATs feel ill prepared to recognize PRM misuse and feel tremendous pressure to provide correct health information to the athlete. The purpose of this study was to expand on …

Application Of The Us Food And Drug Administration’S Sentinel Routine Querying Tools To The Taiwan Sentinel Data Model-Formatted National Health Insurance Research Database, Fang-Ju Lin, Ling-Ya Huang, Chi-Chuan Wang, Sengwee Toh

Journal of Food and Drug Analysis

The U.S. Food and Drug Administration’s Sentinel System is a leading distributed data network for drug safety surveillance in the world. The National Health Insurance Research Database (NHIRD) in Taiwan was converted into the Taiwan Sentinel Data Model (TSDM) based on the Sentinel Common Data Model (SCDM) version 6.0.2. The goal of this study was to investigate the feasibility of applying the same study designs, analytic choices, and analytic tools as used by the U.S. Sentinel System to examine the same drug-outcome associations in the TSDM-formatted NHIRD. Four known drug-outcome associations previously examined by the U.S. Sentinel System were selected …

Dehulled Adlay (Coix Lachryma-Jobi L.) Ameliorates Hepatic Gluconeogenesis And Steatosis In Streptozotocin/High-Fat Diet-Induced Diabetic Rats, Shing-Hwa Liu, Wan-Hsin Wu, Huei-Ping Tzeng, Wenchang Chiang, Meng-Tsan Chiang

Journal of Food and Drug Analysis

Adlay (Coix lachryma-jobi L.) is a traditional Chinese herbal medicine with various biological activities. We investigated the anti-diabetic effects of different parts of adlay seeds, including polished adlay (PA), adlay bran (AB) and dehulled adlay (DA) in a streptozotocin (STZ)/high fat diet (HFD) diabetic rat model (DM). DM rats supplemented with or without PA (43%), AB (3%), or DA (46%) diet for 8 weeks. The plasma glucose and insulin levels and the insulin resistance index (HOMA-IR) were increased in DM group; among the three adlay diets, DA has the best effects attenuating all of these alterations in DM …

Glycine-Rich Peptides From Fermented Chenopodium Formosanum Sprout As An Antioxidant To Modulate The Oxidative Stress, Chen-Che Hsieh, Shu-Han Yu, Hsing-Chun Kuo, Darin Khumsupan, Hsiao-Chu Huang, Yu-Wei Liou, Chen-Yu Kao, Szu-Chuan Shen, Kuan-Chen Cheng

Journal of Food and Drug Analysis

Rhizopus oligosporus was utilized in the solid-state fermentation of Chenopodium formosanum sprouts (FCS) in a bioreactor. Subsequently, the antioxidant activity of food proteins derived from FCS was investigated. Results showed that glycine-rich peptide (GGGGGKP, G-rich peptide), identified from the < 2 kDa FCS proteins, had antioxidant values. According to SwissADME, AllerTOP, ToxinPred, and BIOPEP-UWM analyses, G-rich peptide was identified as safe, non-toxic, and non-allergenic. Afterward, the peptide was examined using in silico and in vitro studies to evaluate its potential alleviating oxidative stress caused by particulate matter. This study proposed plausible mechanisms that involve the binding of G-rich peptide which inhibited phosphorylation of the v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA) subunit on NF-κB pathway. The inhibition then resulted in down regulation of NF-κB transcription and genetic expression of inflammatory …

Personalized Mixed Reality Audio Using Audio Classification Using Machine Learning, Quinn Thuy Tran, Joseph Johnson Jr.

Defensive Publications Series

Traditional audio devices such as over-the-ear or in-ear headphones are limited in their ability to provide a personalized and engaging listening experience. When using such audio devices in a noisy environment, it can be difficult for a user to focus on the audio that is most important. This disclosure describes the use of mixed reality audio to enhance the listening experience via headphones, earbuds, or other audio devices during normal use. Machine learning techniques are used to modify the audio per user preferences, e.g., to focus the audio on a single person talking while the user is in a group, …

The Role Of Self-Sampling For Hpv In The Primary Prevention Of Cervical Cancer, Divya Patel, Kara Roman, Jennifer Christiansen, Justin Gambini

Doctor of Medical Science (DMSc)

Introduction:

Cervical cancer is a striking women's health problem worldwide. It is the fourth most common cancer in women and the seventh most common cancer worldwide1. There were roughly 604,000 new cases of cervical cancer and 342,000 deaths in 20202. Most of these cases occur in developing countries due to ineffective screening initiatives2. Screening essentially allows pre-cancerous lesions to be identified at stages where they can easily be treated; screening methods include cytology and HPV testing (Human Papillomavirus)1. HPV has over 100 strains and is one of the most common risk factors for cervical cancer. HPV testing is more sensitive …

Thoughtful Integration Of Active Learning Teaching Strategies Into Physician Assistant Education, Daniel Berger, Heather Rollins, Curt C. Stilp, Justin M. Gambini

Doctor of Medical Science (DMSc)

Introduction:

The future of healthcare relies upon how we train student clinicians. It is integral to continually reevaluate our methodologies of teaching and work to better approach the challenging task of educating competent and compassionate physician assistants in a short two-to-three-year window. While the traditional modality of teaching has been primarily lecture-based, there has been a growing movement to incorporate active learning into medical education. This learner-driven model puts students in the driver’s seat and allows for greater amounts of self-directed learning prior to class followed by the reinforcement of concepts during class time. Though lecture-based teaching could be the …

Combining The Tyrosine Kinase Inhibitor Cabozantinib And The Mtorc1/2 Inhibitor Sapanisertib Blocks Erk Pathway Activity And Suppresses Tumor Growth In Renal Cell Carcinoma., Yige Wu, Siqi Chen, Xiaolu Yang, Kazuhito Sato, Preet Lal, Yuefan Wang, Andrew T Shinkle, Michael C Wendl, Tina M Primeau, Yanyan Zhao, Alanna Gould, Hua Sun, Jacqueline L Mudd, Jeremy Hoog, R Jay Mashl, Matthew A Wyczalkowski, Chia-Kuei Mo, Ruiyang Liu, John M Herndon, Sherri R Davies, Di Liu, Xi Ding, Yvonne A Evrard, Bryan E Welm, David Lum, Mei Yee Koh, Alana L Welm, Jeffrey Chuang, Jeffrey A Moscow, Funda Meric-Bernstam, Ramaswamy Govindan, Shunqiang Li, James Hsieh, Ryan C Fields, Kian-Huat Lim, Cynthia X Ma, Hui Zhang, Li Ding, Feng Chen

Faculty Research 2023

UNLABELLED: Current treatment approaches for renal cell carcinoma (RCC) face challenges in achieving durable tumor responses due to tumor heterogeneity and drug resistance. Combination therapies that leverage tumor molecular profiles could offer an avenue for enhancing treatment efficacy and addressing the limitations of current therapies. To identify effective strategies for treating RCC, we selected ten drugs guided by tumor biology to test in six RCC patient-derived xenograft (PDX) models. The multitargeted tyrosine kinase inhibitor (TKI) cabozantinib and mTORC1/2 inhibitor sapanisertib emerged as the most effective drugs, particularly when combined. The combination demonstrated favorable tolerability and inhibited tumor growth or induced …