Digital Commons Network^™

Neuropsychiatric Symptoms Of Dementia In Those With And Without A Recorded History Of Psychological Trauma: A Comparative Study From An Australian Dementia Support Service, Monica Cations, Mustafa Atee, Thomas Morris, Daniel Whiting

Research outputs 2022 to 2026

Objective: To compare the number and severity of neuropsychiatric symptoms (NPS) and associated caregiver distress between those with and without a noted history of psychological trauma among those referred to a specialised national dementia NPS support service. Methods: This was a 5-year retrospective observational study of records from the Dementia Support Australia NPS support service. NPS were reported by formal or informal caregivers at service entry using the Neuropsychiatric Inventory Nursing Home version or Questionnaire version. A history of psychological trauma was recorded in the person's social or medical history and/or endorsed as a contributor to NPS by a trained …

Professionalism In Artificial Intelligence: The Link Between Technology And Ethics, Anton Klarin, Hossein Ali Abadi, Rifat Sharmelly

Research outputs 2022 to 2026

Ethical conduct of artificial intelligence (AI) is undoubtedly becoming an ever more pressing issue considering the inevitable integration of these technologies into our lives. The literature so far discussed the responsibility domains of AI; this study asks the question of how to instil ethicality into AI technologies. Through a three-step review of the AI ethics literature, we find that (i) the literature is weak in identifying solutions in ensuring ethical conduct of AI, (ii) the role of professional conduct is underexplored, and (iii) based on the values extracted from studies about AI ethical breaches, we thus propose a conceptual framework …

Region-Specific Drivers Cause Low Organic Carbon Stocks And Sequestration Rates In The Saltmarsh Soils Of Southern Scandinavia, Carmen Leiva-Dueñas, Anna E. L. Graversen, Gary T. Banta, Jeppe N. Hansen, Marie L. K. Schrøter, Pere Masqué, Marianne Holmer, Dorte Krause-Jensen

Research outputs 2022 to 2026

Saltmarshes are known for their ability to act as effective sinks of organic carbon (OC) and their protection and restoration could potentially slow down the pace of global warming. However, regional estimates of saltmarsh OC storage are often missing, including for the Nordic region. To address this knowledge gap, we assessed OC storage and accumulation rates in 17 saltmarshes distributed along the Danish coasts and investigated the main drivers of soil OC storage. Danish saltmarshes store a median of 10 kg OC m−2 (interquartile range, IQR: 13.5–7.6) in the top meter and sequester 31.5 g OC m−2 yr−1 (IQR: 41.6–15.7). …

The Impact Of The Belt And Road Initiative On Green Innovation And Innovation Modes: Empirical Evidence From Chinese Listed Enterprises, Bowen Li, Zijing Zhang, Zhaoyong Zhang

Research outputs 2022 to 2026

Under the Belt and Road Initiative (BRI), promoting green innovation in enterprises has been the central focus of the developmental strategy for China and countries along the Belt and Road to ensure sustainable development in line with the UN Sustainable Development Goals (SDGs) related to the environment and development. This paper examines the driving factors and heterogeneous mechanisms of the BRI in green technology innovation, especially in collaborative vs. independent innovation modes, utilizing a multi-period difference-in-difference model (DID) and micro-level panel data of Chinese listed enterprises spanning from 2007 to 2021. We find that the BRI has significantly stimulated the …

Malware Detection With Artificial Intelligence: A Systematic Literature Review, Matthew G. Gaber, Mohiuddin Ahmed, Helge Janicke

Research outputs 2022 to 2026

In this survey, we review the key developments in the field of malware detection using AI and analyze core challenges. We systematically survey state-of-the-art methods across five critical aspects of building an accurate and robust AI-powered malware-detection model: malware sophistication, analysis techniques, malware repositories, feature selection, and machine learning vs. deep learning. The effectiveness of an AI model is dependent on the quality of the features it is trained with. In turn, the quality and authenticity of these features is dependent on the quality of the dataset and the suitability of the analysis tool. Static analysis is fast but is …

Interbody Material Composition And Bone Morphogenetic Protein-2—Risks And Benefits Of Utilization: A Narrative Review, Rohit Bhan, Francisco Narro Garcia, Brian J. Neumann, Mark J. Lambrechts

2020-Current year OA Pubs

No abstract provided.

A 16-Week Progressive Exercise Training Intervention In Treatment-Naïve Chronic Lymphocytic Leukaemia: A Randomised-Controlled Pilot Study, Frankie F. Brown, Rebecca Oliver, Rachel Eddy, Adam J. Causer, Annabelle Emery, Harrison D. Collier-Bain, David Dutton, Josephine Crowe, Daniel Augustine, John Graby, Daniel Rees, Daniela Rothschild-Rodriguez, Oliver J. Peacock, Sally Moore, James Murray, James E. Turner, John P. Campbell

Research outputs 2022 to 2026

Background: Chronic lymphocytic leukaemia (CLL) typically presents with asymptomatic, early-stage disease that is monitored until disease progression (‘treatment-naïve’ CLL). The objective of this pilot study was to assess the feasibility and preliminary safety of an exercise program in treatment-naïve CLL. We also sought to preliminarily assess the impact of the exercise program on disease activity, as it has been proposed that exercise training may reduce disease outgrowth in treatment-naïve CLL. Methods: A total of 40 treatment-naïve CLL patients were recruited into this randomised-controlled pilot study, and after screening, n = 28 were randomised into a 16-week, home-based, partially supervised, personalised, …

Developing International Guidance To Make Impact Assessment Follow-Up Happen–Reflections On An Interactive Design Process, Angus Morrison-Saunders, Jos Arts, Annette Nykiel, Bruce Muir, Richard Morgan, Patricia Fitzpatrick, Ciaran O’Faircheallaigh, Alberto Fonseca, Charlotta Faith-Ell, Ainhoa González, Jan Albert Wessels, Gesa Geißler, Luis Sánchez, Urmila Jha-Thakur, William Ross, John Glasson

Research outputs 2022 to 2026

To advance impact assessment (IA) practice worldwide the International Association for Impact Assessment (IAIA) has long promoted and published a series of international best practice principles, including the recently revised best practice principles for IA follow-up. IA follow-up refers to any kind of undertaking that seeks to ‘understand the outcomes of projects or plans’ that have been subject to IA. To support the implementation of these principles worldwide, a global guidance document has been developed (published by IAIA in 2024). The aims of this paper are to report on the approach undertaken to this guidance, applying a Delphi method, and …

Effective Land Use Classification Through Hybrid Transformer Using Remote Sensing Imagery, Muhammad Zia Ur Rehman, Syed Mohammed Shamsul Islam, Anwaar Ulhaq, David Blake, Naeem Janjua

Research outputs 2022 to 2026

Recent advances in deep learning for hyperspectral image (HSI) classification have shown exceptional performance in resource management and environmental planning through land use classification. Despite these successes, challenges continue to persist in land use classification due to the complex topology of natural and man-made structures. The uneven distribution of land cover introduces spectral-spatial variability, causing inter- and intra-class similarity. To address this issue, this study adopts a hybrid approach that combines convolutional neural networks (CNNs) and a transformer model. The technique comprises three key components: a spectral-spatial convolutional module (SSCM), a spatial attention module (SAM), and a transformer module. Each …

Optimal Operation Of An Islanded Hybrid Energy System Integrating Power And Gas Systems, Mehrdad Ghahramani, Daryoush Habibi, Seyyedmorteza Ghamari, Asma Aziz

Research outputs 2022 to 2026

Remote communities and geographically isolated areas require a secure supply of energy. Isolated hybrid energy systems offer an effective and reliable solution for delivering power to these regions. However, shifting to renewable energy sources introduces uncertainty challenges for low-inertia stand-alone systems. In this paper, we propose a two-stage energy management strategy to address the uncertainties of wind generation and load consumption while minimizing operational expenses. Furthermore, the study explores the integration of multi-carrier energy networks, in this case electricity and gas, to enhance the reliability of hybrid energy systems. Two modeling methods are proposed to tackle the uncertainties. First, a …

Seeing The Forest For The Trees: The Role Of Growth-Oriented Leadership In Shaping Public Servants’ Work Experiences In The Post-Npm Environment, Esme Franken, Aglae Hernandez Grande, Ben Farr-Wharton, Fleur Sharafizad, Tim Bentley

Research outputs 2022 to 2026

In recent years, growth-oriented leadership (GOL) has come to the fore as a salient predictor of positive employee outcomes in public sector contexts. This empirical paper examines the role of GOL in shaping perceptions of quantitative demands as a product of an evolved New Public Management (NPM) context and the subsequent impact on stress and well-being for 419 local government employees working in Western Australia. While latent in previous GOL-oriented studies, this paper is the first to explore the intersection of GOL and quantitative demands, noting that the former has an established positive effect on employee wellbeing, and the opposite …

Spatially-Aware Speaker For Vision-And-Language Navigation Instruction Generation, Muraleekrishna Gopinathan, Martin Masek, Jumana Abu-Khalaf, David Suter

Research outputs 2022 to 2026

Embodied AI aims to develop robots that can understand and execute human language instructions, as well as communicate in natural languages. On this front, we study the task of generating highly detailed navigational instructions for the embodied robots to follow. Although recent studies have demonstrated significant leaps in the generation of step-by-step instructions from sequences of images, the generated instructions lack variety in terms of their referral to objects and landmarks. Existing speaker models learn strategies to evade the evaluation metrics and obtain higher scores even for low-quality sentences. In this work, we propose SAS (Spatially-Aware Speaker), an instruction generator …

Systemic Treatment Of Recessive Dystrophic Epidermolysis Bullosa With Mesenchymal Stromal Cells: A Scoping Review Of The Literature And Conclusions For Future Clinical Research, Elke Niebergall-Roth, Kathrin Dieter, Markus H. Frank, Mark A. Kluth

Research outputs 2022 to 2026

Background: The ability of mesenchymal stromal cells (MSCs) to facilitate regenerative responses in inflamed and injured tissues, coupled with preclinical data suggesting potential to restore defective collagen VII at the dermo-epidermal junction, has raised the hope that MSCs may provide an effective disease-modifying therapy for patients suffering from recessive dystrophic epidermolysis bullosa (RDEB). Methods: We present a descriptive analysis of the clinical research on systemic MSC administration to RDEB patients available in PubMed, including six early-phase studies and one case report, involving 59 patients who received 1–3 intravenous infusions of MSCs from various sources. Results: Based on 133 MSC infusions, …

Grain Boundary Engineering: An Emerging Pathway Toward Efficient Electrocatalysis, Xiaomin Xu, Yijun Zhong, Magdalena Wajrak, Tejas Bhatelia, San Ping Jiang, Zongping Shao

Research outputs 2022 to 2026

Electrochemical transformation processes involving carbon, hydrogen, oxygen, nitrogen, and small-molecule chemistries represent a promising means to store renewable energy sources in the form of chemical energy. However, their widespread deployment is hindered by a lack of efficient, selective, durable, and affordable electrocatalysts. Recently, grain boundary (GB) engineering as one category of defect engineering, has emerged as a viable and powerful pathway to achieve improved electrocatalytic performances. This review presents a timely and comprehensive overview of recent advances in GB engineering for efficient electrocatalysis. The beneficial effects of introducing GBs into electrocatalysts are discussed, followed by an overview of the synthesis …

Identifying And Promoting Qualitative Methods For Impact Assessment, Heidi Walker, Jenny Pope, Angus Morrison-Saunders, Alan Bond, Alan P. Diduck, A. John Sinclair, Brendan Middel, Francois Retief

Research outputs 2022 to 2026

Qualitative methods for impact assessment (IA) represent a broad spectrum of approaches that are important for realising effective IA practice. The purpose of this paper is to identify and promote qualitative methods that are available for use in contemporary and future (next-generation) IA processes. From an extensive literature review, an international survey (145 responses), expert interviews (48 interviewees), and a workshop attended by 27 IA practitioners, 17 qualitative method categories were identified. These were further subdivided into three classes: conventional qualitative methods, highly participatory methods, and mixed methods. Each method is described, and an indication given of how each can …

It Takes It Out Of The Textbook: Benefits Of And Barriers To Expert By Experience Involvement In Pre-Registration Mental Health Nursing Education, Brenda Happell, Sarah Gordon, John Hurley, Kim Foster, Mike Hazelton, Richard Lakeman, Lorna Moxham, Terri Warner

Research outputs 2022 to 2026

What Is Known on the Subject?: Service user involvement in mental health nursing education is beneficial in terms of attitudinal change to reduce stigma, clinical skill development and enhancing understandings of recovery-oriented practice. Service users as experts by experience have not been embedded within pre-registration nursing programs. Consequently, they remain limited in number, ad hoc and frequently tokenistic. Nurse academics responsible for the design and delivery of pre-registration mental health nursing curricula have a potentially important role in facilitating expert by experience involvement in mental health nursing education. What this Paper Adds to Existing Knowledge: Nurse academics teaching mental health …

Music As A Determinant Of Health Among First Nations People In Australia: A Scoping Narrative Review, Brigitta Scarfe, Kristy Apps, Naomi Sunderland, Phil Graham, Brydie Leigh Bartleet, Glenn Barry, Darren Garvey, Rae Cooper, Clint Bracknell

Research outputs 2022 to 2026

Issue Addressed:

While social determinants frameworks are still popular in research about First Nations health in Australia, a growing body of research prefers cultural determinants of health models. Cultural determinants models provide a holistic, strength-based framework to explain connections between health and contextual factors, including the potential role of music and its impact on social and emotional well-being. Given the growing international recognition of links between music, health, and wellbeing through bodies such as the World Health Organisation, this article examines whether and how music practices are acknowledged in First Nations determinants of health literature.

Methods:

We conducted a scoping …

A Search For Bacteria Identified From Cerebrospinal Fluid Shunt Infections In Previous Surgical Events, Paul Hodor, Christopher E. Pope, Kathryn B. Whitlock, Patrick J. Mcdonald, Jason Hauptman, Lucas R. Hoffman, David D. Limbrick Jr., Tamara D. Simon, Cerebrospinal Fluid Microbiota In Shunts (Climb) Study Group

2020-Current year OA Pubs

Shunt infections are a common complication when treating hydrocephalus by cerebrospinal fluid (CSF) shunt placement. The source of infecting pathogens is not well understood. One hypothesis, which we explored here, is that microorganisms persist chronically in the host long before a symptomatic infection occurs and may be detectable in surgical events preceding infection. A cohort of 13 patients was selected, for which CSF samples were available from an infection episode and from a previous surgery event, which was either an initial shunt placement or a revision. Microbiota were analyzed both directly from CSF and from isolates cultured from CSF on …

Seven-Day Dietary Nitrate Supplementation Clinically Significantly Improves Basal Macrovascular Function In Postmenopausal Women: A Randomized, Placebo-Controlled, Double-Blind, Crossover Clinical Trial, Jocelyn M. Delgado Spicuzza, Jigar Gosalia, Liezhou Zhong, Catherine Bondonno, Kristina S. Petersen, Mary Jane De Souza, Elmira Alipour, Daniel B. Kim-Shapiro, Yasina B. Somani, David N. Proctor

Research outputs 2022 to 2026

Introduction: Cardiovascular disease (CVD) is the leading cause of death in women, with increased risk following menopause. Dietary intake of beetroot juice and other plant-based nitrate-rich foods is a promising non-pharmacological strategy for increasing systemic nitric oxide and improving endothelial function in elderly populations. The purpose of this randomized, placebo-controlled, double-blind, crossover clinical trial was to determine the effects of short-term dietary nitrate (NO3−) supplementation, in the form of beetroot juice, on resting macrovascular endothelial function and endothelial resistance to whole-arm ischemia–reperfusion (IR) injury in postmenopausal women at two distinct stages of menopause. Methods: Early-postmenopausal [1–6 years following their final …

Truth Bounties: A Market Solution To Fake News, Yonathan A. Arbel, Michael D. Gilbert

Articles

False information poses a threat to individuals, groups, and society. Many people struggle to judge the veracity of the information around them, whether that information travels through newspapers, talk radio, TV, or social media. Concerned with the spread of misinformation and harmful falsehoods, much of the policy, popular, and scholarly conversation today revolves around proposals to expand the regulation of individuals, platforms, and the media. While more regulation may seem inevitable, it faces constitutional and political hurdles. Furthermore, regulation can have undesirable side effects and be ripe for abuse by powerful actors, public and private.

This Article presents an alternative …

A Scholarly Judge: The Honorable William Holcombe Pryor Jr., Kenneth M. Rosen

Articles

No abstract provided.

Children's Autonomy Rights Online, Clare Ryan

Articles

No abstract provided.

Lessons Learned From The Moment Study On How To Recruit And Retain A Target Population Online, Across Borders, And With Automated Remote Data Collection, Andrew Belfiglio, Shayleigh Dickson Page, Sara Pettersson, Michelle Van Rijn, Ercole Vellone, Heleen Westland, Kenneth E. Freedland, Christopher Lee, Anna Strömberg, Douglas Wiebe, Subhash Aryal, Barbara Riegel, Tiny Jaarsma

2020-Current year OA Pubs

Increasingly, studies use social media to recruit, enroll, and collect data from participants. This introduces a threat to data integrity: efforts to produce fraudulent data to receive participant compensation, e.g., gift cards. MOMENT is an online symptom-monitoring and self-care study that implemented safeguards to protect data integrity. Facebook, Twitter, and patient organizations were used to recruit participants with chronic health conditions in four countries (USA, Italy, The Netherlands, Sweden). Links to the REDCap baseline survey were posted to social media accounts. The initial study launch, where participants completed the baseline survey and were automatically re-directed to the LifeData ecological momentary …

Characterization Of Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels In Oligodendrocytes., Kyle A Lyman, Ye Han, Andrew P Robinson, Samuel E Weinberg, Daniel W Fisher, Robert J Heuermann, Reagan E Lyman, Dong Kyu Kim, Andreas Ludwig, Navdeep S Chandel, Mark D Does, Stephen D Miller, Dane M Chetkovich

2020-Current year OA Pubs

Mature oligodendrocytes (OLG) are the myelin-forming cells of the central nervous system. Recent work has shown a dynamic role for these cells in the plasticity of neural circuits, leading to a renewed interest in voltage-sensitive currents in OLG. Hyperpolarization-activated cyclic nucleotide-gated (HCN) channels and their respective current (I

An Internet Mantram Repetition Program To Promote Well-Being In Breast Cancer Survivors: A Feasibility Randomized Controlled Trial, Jennifer M Hulett, An-Lin Cheng, Jill E Bormann, Allison B Anbari, Jane M Armer, Brooke M Hartman, B Ann Bettencourt, Leeanne B Sherwin, Edie L Sperling, Natsayakarn Narkthong, Carol Reinero, Hans Rindt, Kathy Schreiber, Lindsay L Peterson, Emily Albright

2020-Current year OA Pubs

No abstract provided.

Bradykinin Receptor Expression And Bradykinin-Mediated Sensitization Of Human Sensory Neurons, Jiwon Yi, Zachariah Bertels, John Smith Del Rosario, Allie J. Widman, Richard A. Slivicki, Maria Payne, Henry M. Susser, Bryan A. Copits, Robert W. Gereau 4th

2020-Current year OA Pubs

Bradykinin is a peptide implicated in inflammatory pain in both humans and rodents. In rodent sensory neurons, activation of B1 and B2 bradykinin receptors induces neuronal hyperexcitability. Recent evidence suggests that human and rodent dorsal root ganglia (DRG), which contain the cell bodies of sensory neurons, differ in the expression and function of key GPCRs and ion channels; whether bradykinin receptor expression and function are conserved across species has not been studied in depth. In this study, we used human DRG tissue from organ donors to provide a detailed characterization of bradykinin receptor expression and bradykinin-induced changes in the excitability …

Trans-Ancestry Epigenome-Wide Association Meta-Analysis Of Dna Methylation With Lifetime Cannabis Use, Fang Fang, Laura J Bierut, Et Al.

2020-Current year OA Pubs

Cannabis is widely used worldwide, yet its links to health outcomes are not fully understood. DNA methylation can serve as a mediator to link environmental exposures to health outcomes. We conducted an epigenome-wide association study (EWAS) of peripheral blood-based DNA methylation and lifetime cannabis use (ever vs. never) in a meta-analysis including 9436 participants (7795 European and 1641 African ancestry) from seven cohorts. Accounting for effects of cigarette smoking, our trans-ancestry EWAS meta-analysis revealed four CpG sites significantly associated with lifetime cannabis use at a false discovery rate of 0.05

Stat1 Employs Myeloid Cell-Extrinsic Mechanisms To Regulate The Neutrophil Response And Provide Protection Against Invasive Klebsiella Pneumoniae Lung Infection, Shekina Gonzalez-Ferrer, Zeyu Xiong, Atish Gheware, Janet S Lee, Et Al.

2020-Current year OA Pubs

Klebsiella pneumoniae (KP) is an extracellular Gram-negative bacterium that causes infections in the lower respiratory and urinary tracts and the bloodstream. STAT1 is a master transcription factor that acts to maintain T cell quiescence under homeostatic conditions. Although STAT1 helps defend against systemic spread of acute KP intrapulmonary infection, whether STAT1 regulation of T cell homeostasis impacts pulmonary host defense during acute bacterial infection and injury is less clear. Using a clinical KP respiratory isolate and a pneumonia mouse model, we found that STAT1 deficiency led to an early neutrophil-dominant transcriptional profile and neutrophil recruitment in the lung preceding widespread …

Cep120 Is Essential For Kidney Stromal Progenitor Cell Growth And Differentiation, Ewa Langner, Tao Cheng, Eirini Kefaloyianni, Charles Gluck, Baolin Wang, Moe R Mahjoub

2020-Current year OA Pubs

Mutations in genes that disrupt centrosome structure or function can cause congenital kidney developmental defects and lead to fibrocystic pathologies. Yet, it is unclear how defective centrosome biogenesis impacts renal progenitor cell physiology. Here, we examined the consequences of impaired centrosome duplication on kidney stromal progenitor cell growth, differentiation, and fate. Conditional deletion of the ciliopathy gene Cep120, which is essential for centrosome duplication, in the stromal mesenchyme resulted in reduced abundance of interstitial lineages including pericytes, fibroblasts and mesangial cells. These phenotypes were caused by a combination of delayed mitosis, activation of the mitotic surveillance pathway leading to apoptosis, …

Non-Invasive Auricular Vagus Nerve Stimulation For Subarachnoid Hemorrhage (Navsah): Protocol For A Prospective, Triple-Blinded, Randomized Controlled Trial, Anna Huguenard, Gansheng Tan, Gabrielle Johnson, Markus Adamek, Andrew Coxon, Terrance Kummer, Joshua Osbun, Ananth Vellimana, David Limbrick, Gregory Zipfel, Peter Brunner, Eric Leuthardt

2020-Current year OA Pubs

BACKGROUND: Inflammation has been implicated in driving the morbidity associated with subarachnoid hemorrhage (SAH). Despite understanding the important role of inflammation in morbidity following SAH, there is no current effective way to modulate this deleterious response. There is a critical need for a novel approach to immunomodulation that can be safely, rapidly, and effectively deployed in SAH patients. Vagus nerve stimulation (VNS) provides a non-pharmacologic approach to immunomodulation, with prior studies demonstrating VNS can reduce systemic inflammatory markers, and VNS has had early success treating inflammatory conditions such as arthritis, sepsis, and inflammatory bowel diseases. The aim of the Non-invasive …