Three Essays In Urban And Regional Economics, Bryan Khoo Wyng Wai

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation "Three Essays in Urban and Regional Economics" contains three chapters which explore urban and regional economics. The first chapters focuses on examining the effect of stadiums on congestion; the second chapter on the effect of military base closures on the housing market; and the third chapter is a meta-analysis on historical instrumental variables.

The first chapter examines the effect of National Football League games on traffic congestion in Cincinnati, Ohio; Seattle, Washington; and Santa Clara, California during the 2018 and 2019 seasons. By linking sporting events to traffic congestion, this paper provides the mechanism for stadiums generating additional …

Ethics In Action: Exploring B Corporation Certification, Value Congruence, And Empathy Within Organizations, Jiahui Lu

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation is comprised of three studies. It explores ethical practices within organizational settings from three different perspectives: a macro perspective, an individual perspective, and a micro-level interaction perspective. The first study examines the earnings management behavior of B Corporation managers, providing a macro view of how an external corporate certification may address the broader issue of business ethics. The findings of this study contribute to the legitimacy of B Corporations and our understanding of the relationship between corporate social responsibility and earnings management. The second study investigates the effect of value congruence on employee whistleblowing at for-profit social mission …

Are Two Heads Better Than One? Investigating The Influence Of Collaboration On Creativity, Alexander Knopps

Psychology

Creativity and collaboration are considered fundamental skills for student success in STEM Education (Karimi & Pina, 2021) and are consistently among the top-ranked skills for employers (Flaherty, 2021). To assess creativity, the Remote Association Task (RAT) is an increasingly used tool to measure creative problem-solving (Wu et al., 2021). However, no research has systematically investigated the effectiveness of working collaboratively versus individually using this measure. The current research evaluates how collaboration impacts creative problem-solving using the RAT. Participants worked collaboratively or individually to solve 20 RAT problems (Experiments 1-2) and completed a later, individual test that involved the same 20 …

A Quality Improvement Initiative To Reduce Preanalytical Blood Gas Errors, Layla Haver Newbrough

Graduate Theses, Dissertations, and Problem Reports (ETD)

Abstract

Introduction: Laboratory testing is one of the most commonly performed procedures in healthcare and resulting data are paramount to clinical decision making. Background: Preanalytical blood gas laboratory errors often stem from the incorrect recording of a patient’s fraction of inspired oxygen (FiO2) within the laboratory collection application. Incorrect FiO2 may cause erroneous results or delays in reporting results that have the potential to negatively impact patient safety and medical management.

Purpose: The purpose of this quality improvement initiative was to reduce the occurrence of preanalytical blood gas laboratory errors. Methods/Interventions: This initiative combined modification of the laboratory collection application …

Gating Of Food And Non-Food Information From Working Memory, Emily Johnson

Psychology

Prior research has suggested that biased attention towards food cues in the environment may contribute to the onset and maintenance of binge eating. Here, we examine whether individuals who report high levels of binge eating also have difficulty keeping task-irrelevant food-related information out of working memory (WM). To investigate this, we used the contralateral delay activity (CDA), a neurophysiological measure reflecting the amount of information held in WM. Experiment 1 confirmed differences in behavioral performance and CDA amplitude when holding one versus two items in WM and between stimulus type (food vs. non-food). Experiment 2 replicated these behavioral findings but …

Implementation Of Bayesian Statistics To Answer Diverse Engineering Questions: Applications In Cancer Immunology And Engineering Education, Anika C. Pirkey

Graduate Theses, Dissertations, and Problem Reports (ETD)

Quantitative Systems Pharmacology (QSP) refers to a mechanistic modeling approach used for assessing potential therapeutics by linking the molecular and cellular level mechanisms of the disease and therapeutic to the system-wide dynamics and clinical endpoints relevant to the disease. Although the field of QSP is still in its relative infancy, the mathematical methodology employed to predict the kinetics of these systems are not new and can be applied to a wide variety of systems. For instance, similar to QSP’s goal of guiding the development of novel therapeutics for various disease states, there exists a need to develop novel interventions in …

Ung: A Diagnostic Standard C Library, Jakob Knute Kaivo

Graduate Theses, Dissertations, and Problem Reports (ETD)

Undefined behavior in C programs is a major source of unreliable software. Many of the most common exploitable software vulnerabilities can be traced directly to undefined behavior. In the increasingly connected world, a successful attack can cost the victim millions of dollars to recover from. While static program analysis aids in identifying undefined behavior, testing indicates that even the best static analysis tools correctly identifies about 35% of these defects. This dissertation introduces UNG’s Not GNU (UNG), a standard C library designed to mitigate undefined behavior. Where others have seen opportunities for optimization, UNG makes every effort to identify undefined …

Characterizing 4,4’-Methylene Diphenyl Diisocyanate Exposure In Primary Human Epidermal Keratinocytes: A Multi-Omics Approach, Brandon F. Law

Graduate Theses, Dissertations, and Problem Reports (ETD)

Exploring the routes of exposure and biological fate of 4,4’-methylene diphenyl diisocyanate (MDI) has been a challenge for many years. Occupational exposure to MDI can result in the development of occupational asthma (MDI-OA) which results in loss of productivity, large economic costs, and costs to the individual worker. Initially, it was thought that respiratory exposure to MDI was the most likely route leading to MDI-OA. Industries utilizing MDI have been successful at controlling airborne concentrations according to industrial hygiene assessment and newly diagnosed cases of MDI-OA decreased and plateaued. New research suggests that dermal exposures to MDI may explain this …

Applying A Modern Situational Measure To Improve The Reliability, Validity, And Outcome Predictability Of Dream Assessment, Odalis Garcia

Psychology

Dreams are hallucinatory activity occurring during sleep that nearly everyone experiences. To understand and research dreams, the field needs a reliable and valid dream assessment tool. The current, most used, measure (Hall and Van de Castle measure) has presented with various reliability and validity issues since its development in 1966. I propose adapting the DIAMONDS taxonomy for situational characteristics to assess dream content. The validation process of this adapted measure has begun with foundational work informing the development of dream-specific subscales. In two preliminary studies I provide some evidence for substantive and structural validity of the adapted measure. Interim data …

A Structured Diabetes Continuous Glucose Monitor Education Program To Improve Patient Knowledge And Self-Efficacy, Krystal Abucevicz-Swick

Graduate Theses, Dissertations, and Problem Reports (ETD)

Introduction/background: Continuous glucose monitor (CGM) is a recommended method of glucose monitoring for patients living with diabetes who are on insulin or experience documented hypoglycemia. CGM is a tool that can improve patient management of diabetes but works best when paired with education to achieve the maximum therapeutic benefits.

Purpose: The purpose of this project was (1) to develop an evidence-based structured CGM education program toolkit for people with diabetes who are ordered CGM, (2) to implement the CGM education toolkit into the Diabetes Self-Management and Education Services (DSMES) program at the project site, (3) to improve patient knowledge about …

Taking The Red Pill: A Content Analysis Of Ambivalent Sexism And Precarious Manhood In Alpha Male Podcasts, Madalen Lea Fields

Graduate Theses, Dissertations, and Problem Reports (ETD)

Podcasts have become increasingly popular across various platforms (e.g., Spotify or Apple podcasts). A more recent trend is the emergence of “alpha male” podcasts. The goal of these podcasts is to instruct young men how to stop being “betas” and on achieving “alpha male” status. These podcasts are a subset of the manosphere, a term used to describe media focused especially on hegemonic masculinity, which is characterized by their promotion of misogynistic beliefs and sexist rhetoric. Drawing upon social science research, three forms of sexism (i.e., ambivalent sexism, precarious manhood and violence against women) serve as analytical frameworks for understanding …

Experimental And Chemical Modeling Of Applied Dc Electric Field Induced H2 – Air Axisymmetric Laminar Co-Flow Diffusion Flames With Low Carbon Impurities, Susith Dilshan Pathmasiri Gunamuni Halowitage

Graduate Theses, Dissertations, and Problem Reports (ETD)

The effect of externally applied DC electric fields on flame structure was investigated in a stationary atmospheric axisymmetric laminar H₂–Air flame with less than 100 ppm carbon equivalent impurities. Flame OH chemiluminescence signals were recorded using a UV-sensitive CCD array as a function of voltage (+10 to -10 kV) applied to a stainless-steel ring electrode placed around the burner nozzle. Changes in chemiluminescence signal are reported as a function of electrode height above the burner, airflow, and fuel composition. Significant changes in OH* distributions were observed for voltages below -5 kV. Under optimum conditions, the height of the …

On Uncertainty For Ill-Posed Robot Decision Problems, Jared Joseph Beard

Graduate Theses, Dissertations, and Problem Reports (ETD)

As robots adopt more real world responsibilities, they will be expected to solve more complicated problems. In some cases limited prior knowledge will result in unmodelled environmental conditions; in others, multiple users may have competing perspectives on how to frame a decision problem. Many existing frameworks, namely Markov decision processes (MDP) presuppose users have identified a specific problem with models sufficient to solve or learn a problem. If we wish to extend MDPs to novel problems or those heavily dependent on user feedback, autonomous decision makers must be able to identify limitations in how a given problem is framed and …

The Effects Of Feed Manufacture On Exogenous Enzymes, Starch Gelatinization, And Antinutritional Factors Associated With Soybeans, Kristina M. Bowen

Graduate Theses, Dissertations, and Problem Reports (ETD)

This doctorate dissertation consists of four individual studies with the overarching theme of the effect of feed manufacture on exogenous enzymes and antinutrients found in soybeans.

Study 1. Including exogenous enzymes in poultry diets can liberate nutrients that are typically inaccessible to monogastric animals. Phytase feeding research has traditionally been conducted by rearing broilers in raised wire cages, whereas commercially grown broilers are reared on built-up litter. Therefore, cage-based studies may not accurately represent commercial bird performance response to phytase. Birds with access to litter consume it, possibly increasing phosphorus intake leading to suggestions that lower phytase concentrations are required. …

School Counselors' Use Of Movement In Small Group And Individual Counseling Sessions, Amy Geinert

Psychology

Although there is a research base for incorporating movement into teaching and classroom lessons, there currently is a lack of research on incorporating movement into school counseling practices. The present mixed methods exploratory study aimed to identify school counselor attitudes, beliefs, and practices regarding the use of movement in individual and small group counseling sessions. A concurrent embedded strategy was utilized to survey practicing school counselors in the United States. By sharing requests through the ASCA Member Community and state school counselor association communications, study participants were invited to complete an anonymous survey online. Study participants indicated they find incorporating …

Effects Of Synonymous And Nonsynonymous Cyp51 Mutations On Dmi Resistance In Cercospora Beticola, Isaac Courneya

Plant Pathology

Cercospora beticola is the most devastating foliar pathogen of sugar beet. This pathogen is primarily managed by the application of fungicides, including demethylation inhibitors (DMIs). Given the broad use of DMIs in managing Cercospora leaf spot, resistance has developed. Recently, five haplotypes of CbCyp51 have been correlated with DMI resistance. To improve our understanding of these haplotypes, this study has evaluated CbCyp51 expression across haplotypes with and without DMI exposure using RT-qPCR. Significant differences were found between haplotypes in control and difenoconazole groups, but the broader implications were unclear. This study also produced mutant C. beticola strains with replaced CbCyp51 …

The Global Alpl Gene Variant Classification Project: Dedicated To Deciphering Variants., Mariam R. Farman, Catherine Rehder, Theodora Malli, Cheryl Rockman-Greenberg, Kathryn Dahir, Gabriel Ángel Martos-Moreno, Agnès Linglart, Keiichi Ozono, Lothar Seefried, Guillermo Del Angel, Gerald Webersinke, Francesca Barbazza, Lisa K. John, Sewmi M A Delana Mudiyanselage, Florian Högler, Erica Burner Nading, Erin Huggins, Eric T. Rush, Ahmed El-Gazzar, Priya S. Kishnani, Wolfgang Högler

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Hypophosphatasia (HPP) is an inherited multisystem disorder predominantly affecting the mineralization of bones and teeth. HPP is caused by pathogenic variants in ALPL, which encodes tissue non-specific alkaline phosphatase (TNSALP). Variants of uncertain significance (VUS) cause diagnostic delay and uncertainty amongst patients and health care providers.

RESULTS: The ALPL gene variant database (https://alplmutationdatabase.jku.at/) is an open-access archive for interpretation of the clinical significance of variants reported in ALPL. The database contains coding and non-coding variants, including single nucleotide variants, insertions/deletions and structural variants affecting coding or non-coding sequences of ALPL. Each variant in the database is displayed with details …

Statistical Analysis Of Single-Cell Protein Data., Brooke L. Fridley, Simon Vandekar, Inna Chervoneva, Julia Wrobel, Siyuan Ma

Manuscripts, Articles, Book Chapters and Other Papers

Immune modulation is considered a hallmark of cancer initiation and progression, with immune cell density being consistently associated with clinical outcomes of individuals with cancer. Multiplex immunofluorescence (mIF) microscopy combined with automated image analysis is a novel and increasingly used technique that allows for the assessment and visualization of the tumor microenvironment (TME). Recently, application of this new technology to tissue microarrays (TMAs) or whole tissue sections from large cancer studies has been used to characterize different cell populations in the TME with enhanced reproducibility and accuracy. Generally, mIF data has been used to examine the presence and abundance of …

Distinct Reproductive Phenotypes Segregate With Differences In Body Weight In Adolescent Polycystic Ovary Syndrome., Angie Chen-Patterson, Angelina Bernier, Tania S. Burgert, Vanessa Davis, Tazeena Khan, David Geller, Emily Paprocki, Rachana Shah, Selma F. Witchel, Camila Pereira-Eshraghi, Aviva B. Sopher, Melanie G. Cree, Laura C. Torchen

Manuscripts, Articles, Book Chapters and Other Papers

INTRODUCTION: Polycystic ovary syndrome (PCOS) is a heterogenous clinical syndrome defined by hyperandrogenism and irregular menses. In adult women with PCOS, discrete metabolic and reproductive subgroups have been identified. We hypothesize that distinct phenotypes can be distinguished between adolescent girls who are lean (LN-G) and girls with obesity (OB-G) at the time of PCOS diagnosis.

METHODS: Data were extracted from the CALICO multisite PCOS database. Clinical data collected at the time of diagnosis were available in 354 patients (81% with obesity) from 7 academic centers. Patients with body mass index (BMI) < 85th percentile for age and sex were characterized as lean (LN-G) and those with BMI percentile ≥ 95th percentile as obese (OB-G). We compared metabolic and reproductive phenotypes in LN-G and OB-G.

RESULTS: Reproductive phenotypes differed between the groups, with LN-G …

Foreign Policy Reorientation: From Globalization To Nationalism, Abdullah A. Asiri

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation explores the foreign policy implications of the post-2010 resurgence of nationalism in the U.S., Europe, and other parts of the world. It explores the reorientation of foreign policy away from globalization and the post-Cold War expectations that include a rules-based order, the spread of democracy and human rights, and the free movement of capital, products, people, and information. Instead, the emerging nationalist foreign policies emphasize independence and national sovereignty, economic self-sufficiency and protectionism, and anti-democracy and universal values. These policies are also characterized in terms of limited and unilateral engagement and proneness to conflict and confrontation. This dissertation …

A Randomized Controlled Trial Of Group Telehealth Workshops Based On Parent-Child Interaction Therapy For Caregivers Of Children With Autism Spectrum Disorder, Erinn J. Victory

Graduate Theses, Dissertations, and Problem Reports (ETD)

Autism spectrum disorder (ASD) is a neurodevelopmental disorder associated with various symptoms that interfere with functioning requiring intensive early intervention; however, many families experience barriers to accessing behavioral services due to provider shortages, cost of treatment, and lack of transportation. Parent-Child Interaction Therapy (PCIT) has demonstrated effectiveness as a supplemental treatment for disruptive behaviors in children on the autism spectrum. The current study aims to determine the efficacy of a 2-day group telehealth parent-only workshop based on PCIT for improving caregivers’ use of positive parenting skills, child disruptive behavior, compliance to caregiver commands, and child psychosocial functioning. Thirty-three caregivers and …

The Impact Of Normal Growth On The Ap Relationships Of The Jaws And Incisors To The Forehead: A Serial Cephalometric Analysis Of Untreated Individuals, Adam Joseph Rudmann Dr

Graduate Theses, Dissertations, and Problem Reports (ETD)

Abstract

The Impact of Normal Growth on the AP Relationships of the Jaws and Incisors to the Forehead: A Serial Cephalometric Analysis of Untreated Individuals

Adam Rudmann D.D.S. M.S.

Background and Objectives

Growth of the craniofacial complex is a critical factor to consider when treatment planning an orthodontic case. The ability to predict how the forehead and jaws will change over time depends on the ability to find predictable landmarks either radiographically or clinically, and use them to gauge the relative growth of various facial structures. This data can then be integrated with other diagnostic information such as occlusion and …

Health Benefits And Adverse Effects Of Kratom: A Social Media Text-Mining Approach, Abdullah Wahbeh, Mohammad Al-Ramahi, Omar F. El-Gayar, Tareq Nasralah, Ahmed Elnoshokaty

Research & Publications

Background: Kratom is a substance that alters one’s mental state and is used for pain relief, mood enhancement, and opioid withdrawal, despite potential health risks. In this study, we aim to analyze the social media discourse about kratom to provide more insights about kratom’s benefits and adverse effects. Also, we aim to demonstrate how algorithmic machine learning approaches, qualitative methods, and data visualization techniques can complement each other to discern diverse reactions to kratom’s effects, thereby complementing traditional quantitative and qualitative methods. Methods: Social media data were analyzed using the latent Dirichlet allocation (LDA) algorithm, PyLDAVis, and t-distributed stochastic neighbor …

Light-Assisted 3d Printing Of Continuous Carbon Fiber Reinforced Thermoset Composites, Md Zahirul Islam

Mechanical Engineering and Applied Mechanics

Polymer 3D printing has become an emerging manufacturing technique, due to its design flexibility, however its application to produce structural components is still limited due to the poor mechanical strength and thermal stability of most 3D printed parts. Because of the superior mechanical strength of carbon fiber, 3D printing of continuous carbon fiber reinforced thermoset composites have recently been studied overcome this barrier of mechanical strength and thermal stability. Light- curing based 3D printing of continuous carbon fiber shows a promising potential, however this process also has limitations in making custom object due to fiber loop creation as the nozzle …

Additive Manufacture Of Advanced Composites Using Reactive Resins And Continuous Carbon Fiber, Bibek Aryal

Mechanical Engineering and Applied Mechanics

To overcome the significant limitations such as slow processing times, substantial energy needs of conventional additive manufacturing technology, reactive extrusion additive manufacturing (REAM) process was developed. As printed objects with neat reactive resin exhibited insufficient mechanical performance for advanced application, continuous fiber reinforcement is an effective route to improve mechanical performances. Continuous carbon fiber reinforced 3D printing was performed using a commercially available reactive resin system and an experimentally synthesized one at NDSU. The mechanical properties of the printed carbon fiber reinforced samples were compared with the neat resin samples. The tensile strength of printed sample using Pentaerythritol-xylendiamine resin system …

An Examination Of Selected Chinese Ethnic Choral Music From Inner Mongolia, Yunnan Province, And Central Plains Area, Kewen Cheng

Music

The landscape of choral music in modern China is characterized by a rich and varied repertoire, despite its relatively brief history within the nation. Diverging from the trajectories of traditionally Christian countries, the evolution of Chinese choral music has been shaped by unique historical, social, religious, and folk music traditions. This paper embarks on an examination of selected Chinese ethnic choral music, commencing with an overview of the development path of Chinese choral music in Chapter One. It then delves into an analysis of choral traditions across three distinct ethnic regions in the following three chapters. Each of them is …

Graph Two-Sample Test Via Empirical Likelihood, Ting Zou

Statistics

In the past two decades, there has been a notable surge in network data. This proliferation has spurred significant advancements in methods for analyzing networks across various disciplines, including computer science, information sciences, biology, bioinformatics, physics, economics, sociology, and health science. Graph two-sample hypothesis testing, aimed at discerning differences between two populations of networks, arises naturally in diverse scenarios. In this paper, we delve into the essential yet intricate task of testing for equivalence between two networks. There are many testing procedures available. For instance, the t-test based on subgraph counts is one of the methods. In this paper, we …

Monte-Carlo Method For Identifying Aberrantly Expressed Genes In Cancer, Matthew M. Beltran

Theses and Dissertations

Gene expression provides insight into the functional variations on the cellular level that shape biological phenomena. Several recent sequencing technologies have produced an abundance of expression profiles spurring entirely new disciplines of biological study. With this myriad of data, the new task is deciding how to assess and extract meaningful insights. Identifying genes with expression changes in disease conditions is often the first step in finding potential biomarkers for diagnosis, and targets for pharmaceutical treatments. Parametric statistical tests at the individual gene level have been the conventional approach for finding differentially expressed genes. These tests exhibit high statistical power but …

Mass Political Murder: What And Where Is The Hate?, Clark Mccauley

Psychology Faculty Research and Scholarship

This article explores the meaning and importance of hate in intergroup conflict, especially in conflict that moves to genocide or politicide. Review of controversies in defining hate leads to definition of hate as an extreme form of negative identification that includes perception of bad essence. Negative identification is inverse caring for others, as seen in studies of schadenfreude and gluckschmerz. Studies of dehumanization suggest that two forms of bad essence can be distinguished: evil human (entitativity essentializing) and infrahuman animal (natural kind essentializing). Studies also show that those who essentialize more are more ready to punish indiscriminately all …

The Ubiquity Of Time In Latent-Cause Inference, Dan-Mircea Mirea, Yeon Soon Shin, Sarah Dubrow, Yael Niv

Psychology Faculty Research and Scholarship

Humans have an outstanding ability to generalize from past experiences, which requires parsing continuously experienced events into discrete, coherent units, and relating them to similar past experiences. Time is a key element in this process; however, how temporal information is used in generalization remains unclear. Latent-cause inference provides a Bayesian framework for clustering experiences, by building a world model in which related experiences are generated by a shared cause. Here we examine how temporal information is used in latent-cause inference,using a novel task in which participants see ‘microbe’ stimuli and explicitly report the latent cause (‘strain’) they infer for each …