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Chronic Training Load And Dorsiflexion Range Of Motion Throughout A Season In Professional American Soccer, Tristan L. Young Jan 2024

Chronic Training Load And Dorsiflexion Range Of Motion Throughout A Season In Professional American Soccer, Tristan L. Young

College of Graduate Studies: Theses & Dissertations

Soccer has an incredibly complex movement profile. Players experience various types of strains on their body from the requirement to land in awkward positions while maintaining the ability to quickly accelerate and decelerate. Dorsiflexion range of motion (DFROM) is of concern due to the movement profile and ball control that requires constant eccentric and concentric actions at the talocrural joint. With an American soccer season spanning across nine months these demands can contribute to overuse, which has been linked to restricted range of motion. Restricted DFROM and asymmetries have been identified as injury predictors, but their relationship to performance has …


Snake Translocation Policies And Practices Within The United States, Robin E. Bedard, Megan Rottenborn, Emily Taylor Jan 2024

Snake Translocation Policies And Practices Within The United States, Robin E. Bedard, Megan Rottenborn, Emily Taylor

Human–Wildlife Interactions

Human–wildlife conflict with nuisance snakes (Serpentes) is rapidly increasing with human population growth and development rates. Translocation of nuisance snakes has become a widespread practice, aided by social media pages connecting people to volunteer and for-profit snake translocators. However, translocators often struggle to find information and resources from wildlife agencies about the policies required, and some may unintentionally use translocation procedures that disregard the health and survival of the snakes. The goals of this study were to (1) obtain data on policies, permitting, and training required for translocating nuisance snakes in each U.S. state that has snakes and (2) compare …


Impact Of Road Infrastructures On The Abundance Of Common Chameleon Populations, Pablo García-Quevedo, Francisco Díaz-Ruiz, Antonio Román Muñoz, Jesús Duarte, Adrián Martín-Taboada, José-María García-Carrasco, Miguel Ángel Farfán Jan 2024

Impact Of Road Infrastructures On The Abundance Of Common Chameleon Populations, Pablo García-Quevedo, Francisco Díaz-Ruiz, Antonio Román Muñoz, Jesús Duarte, Adrián Martín-Taboada, José-María García-Carrasco, Miguel Ángel Farfán

Human–Wildlife Interactions

The common chameleon (Chamaeleo chamaeleon) is a threatened species in Spain. The loss and transformation of their traditional habitats are among the main causes of its decline. Linear infrastructures, such as roads and highways, cause direct habitat loss, roadkill, and fragmentation of populations by acting as an artificial barrier. In this study, we investigated the potential effect of 2 high-speed road infrastructures in southern Spain on local populations of common chameleons. A total of 34 grids of 1x1 km were sampled, differentiating between grids without road presence (n = 17) and grids with road presence (n …


Exploring Police K-9 Deaths, Their Causes, And Possible Remedies, John Wise Jan 2024

Exploring Police K-9 Deaths, Their Causes, And Possible Remedies, John Wise

College of Graduate Studies: Theses & Dissertations

Police K-9s face daily dangers due to their work. Data collected by the Officer Down Memorial Page from 2000-2023 on K-9 deaths (N = 405) shows that of K-9s that die in the line of duty, many fall victim to heat stroke. Research was conducted comparing heat stroke to all other causes of death. Through an exploration into the history of mankind’s use of working dogs, the unique capabilities of both dogs and K-9 specific dog breeds and applying Routine Activity Theory and Lifestyle Routine Activity Theory to police K-9s, this study’s objective is to bring awareness to, and …


Bringing Gans To Medieval Times: Manuscript Translation Models, Tonilynn M. Holtz Jan 2024

Bringing Gans To Medieval Times: Manuscript Translation Models, Tonilynn M. Holtz

College of Graduate Studies: Theses & Dissertations

The Generative Adversarial Networks (GAN) recently emerged as a powerful framework for producing new knowledge from existing knowledge. These models aim to learn patterns from input data then use that knowledge to generate output data samples that plausibly appear to belong to the same set as the input data. Medieval manuscripts study has been an important research area in the humanities field for many decades. These rare manuscripts are often times inaccessible to the general public, including students in scholars, and it is of a great interest to provide digital support (including, but not limited to translation and search) for …


The U.S. Southern Mothers Perspective On Affection, Destiny M. Rose Jan 2024

The U.S. Southern Mothers Perspective On Affection, Destiny M. Rose

College of Graduate Studies: Theses & Dissertations

This qualitative research study utilizes Murray Bowen’s Family Systems Theory and Kimberlé Crenshaw’s Intersectionality Theory to examine how ten mothers residing in what is identified as the U.S. Deep South (Georgia, Alabama, and South Carolina) perceive affection shown to their children by adults outside of their nuclear family. Additionally, this study considers the influence social class plays in how parents in the Deep South navigate and negotiate social and cultural norms when it comes to affection displays shown to their children. Data was collected using thematic analysis to describe how parents in parts of the Deep South perceive affection shown …


Integration Of Infrared Thermography And Deep Learning For Real-Time In-Situ Defect Detection And Rapid Elimination Of Defect Propagation In Material Extrusion, Asef Ishraq Sadaf Jan 2024

Integration Of Infrared Thermography And Deep Learning For Real-Time In-Situ Defect Detection And Rapid Elimination Of Defect Propagation In Material Extrusion, Asef Ishraq Sadaf

College of Graduate Studies: Theses & Dissertations

This study presents a novel approach to overcoming process reliability challenges in Material Extrusion (ME), a prominent additive manufacturing (AM) technique. Despite ME's advantages in cost, versatility, and rapid prototyping, it faces significant barriers to commercial-scale production, primarily due to quality issues such as overextrusion and underextrusion, which compromise final part performance. Traditional manual monitoring methods severely lack the capability to efficiently detect these defects and highlight the necessity for an efficient and real-time monitoring solution. Considering these challenges, an innovative and field-deployable infrared thermography-based in-situ real-time defect detection and feedback control system is proposed in this thesis. A novel …


Always A Dreamer, Liz Walker Jan 2024

Always A Dreamer, Liz Walker

College of Graduate Studies: Theses & Dissertations

ABSTRACT

This is the story of my life in the form of a memoir. You might ask, why is my life a relevant subject for a dissertation? As Celeste Snowber, the scholar, author and performer recently said to me, “I think it would be wonderful to write a memoir.... You clearly have an extraordinary life, with art, soul and the depths of wisdom marinating all you do” (2023, personal communication). I was flattered by her comments and her confidence in me gave me the inspiration I needed to tell my story. There is also the meaning of ‘lived experience’ in …


The Effect Of First-Person Testimonial Versus Didactic Video Interventions On Attitudes And Behavioral Intentions Toward Buprenorphine, Tristan S. Fletcher Jan 2024

The Effect Of First-Person Testimonial Versus Didactic Video Interventions On Attitudes And Behavioral Intentions Toward Buprenorphine, Tristan S. Fletcher

College of Graduate Studies: Theses & Dissertations

Emerging adults exhibit disproportionately elevated levels of substance use disorders (Substance Abuse and Mental Health Services Administration [SAMHSA], 2021), opioid misuse (SAMHSA, 2021), and opioid use (Hu et al., 2017; Jones et al., 2015) compared to other age cohorts. If left untreated, opioid misuse and opioid use disorder can lead to various negative consequences, including premature death (Strang et al., 2020). Prior research indicates emerging adults have higher opioid-related mortality rates compared to other age groups in the United States (Gomes et al., 2018). Buprenorphine, an opioid partial agonist medication, is an effective intervention for opioid use disorder (Mattick et …


Effects Of Additions On The Microstructure, Macrostructure, And Mechanical Properties Of Gray Iron, Evan J. Carter Jan 2024

Effects Of Additions On The Microstructure, Macrostructure, And Mechanical Properties Of Gray Iron, Evan J. Carter

College of Graduate Studies: Theses & Dissertations

The iron matrix is a major component of the gray iron (GI) microstructure, which is the transformation product of austenite during solidification. It is generally accepted that the structure of the austenite will impact the final grain structure and thus the properties of GI. Refinement of the austenite grain structure has the potential to increase the strength of GI. Knowledge of controlling austenite grain size with common alloy additions in GI is very limited and is investigated in this research. Utilizing the DAAS heat treatment process, the austenite grain boundaries can be retained and observed directly. The observations were correlated …


Meeting The Moment: Seeking A Symbiosis Of Economic Theory And Practice In Times Of Crisis, Sallie Taylor Manning Jan 2024

Meeting The Moment: Seeking A Symbiosis Of Economic Theory And Practice In Times Of Crisis, Sallie Taylor Manning

College of Graduate Studies: Theses & Dissertations

By their nature, crises upset the status quo and shake apart the ways of being and doing for individuals, families, communities, nations, institutions, and governments. This research seeks to identify the ways in which times of crisis led to changes in high school economics curriculum. The Georgia Performance Standards for high school economics curriculum were examined over a 23-year period to determine the extent to which three national and international crises led to changes in economics curriculum. A historiography was created for each of three crises, September 11, 2001 (9/11), Hurricane Katrina, and the Great Recession of 2008. The Georgia …


Their Country: Black Women, Three Chords, And The Truth, Dmetri J. Smith Jan 2024

Their Country: Black Women, Three Chords, And The Truth, Dmetri J. Smith

College of Graduate Studies: Theses & Dissertations

ABSTRACT

Country music has long overlooked and at times outright erased the contributions of people of African descent. The past and present contributions of Black women are particularly ignored. Country music— a racially contested space centered in Nashville, Tennessee— is imbued with themes referencing the “good ole days” that were dangerous times for anyone who was not White, male, cisgender, and heterosexual. The genre has only become slightly more welcoming to those who are not part of the dominant class. And yet, there are Black women who feel called to use country music as their storytelling medium. My research shows …


Investigating Division Quest: A Text-Based Adventure Narrative Game For Overcoming Difficulties Of Mitosis Learning, Amanda G. Conner Jan 2024

Investigating Division Quest: A Text-Based Adventure Narrative Game For Overcoming Difficulties Of Mitosis Learning, Amanda G. Conner

College of Graduate Studies: Theses & Dissertations

Mitosis learning is a source of struggle for many introductory biology students. Much of this difficulty stems from an overwhelming amount of terminology and moving pieces as well as the abstract nature of cellular processes. Game-based learning (GBL) has been used in other contexts to reduce cognitive load and provide relatable experiences upon which students can construct their mental models. However, commercial GBL is often expensive and difficult to align with individual instructor teaching preferences and learning objectives. In this study, we use a mixed methods approach to explore the use of a GBL tool made in Twine to overcome …


Numerical Analysis Of A Novel Elastohydrodynamic Seal For Supercritical Co2 Power Cycles With Experimental Verification, Ali Akbor Topu Jan 2024

Numerical Analysis Of A Novel Elastohydrodynamic Seal For Supercritical Co2 Power Cycles With Experimental Verification, Ali Akbor Topu

College of Graduate Studies: Theses & Dissertations

Supercritical carbon dioxide (sCO2) power cycles outperform conventional thermodynamic cycles regarding the efficiency and equipment footprint because of its unique property of maintaining the density of liquid in the gaseous phase at supercritical state (304.13 K and 7.37 MPa). It has robust use in concentrated solar power, fossil fuel power plants, geothermal electricity, nuclear power, and ship propulsion. To fully utilize sCO2 power cycles, technology readiness must be demonstrated at 10-60 MWe scale, with a working temperature and pressure of 350-700°C, and 10-35 MPa respectively. A crucial obstacle to the full realization of this technology is the absence …


Dungeons And Dragons™ (D&D) As A Brief Intervention For College Students, Alexander W. Peralta Jan 2024

Dungeons And Dragons™ (D&D) As A Brief Intervention For College Students, Alexander W. Peralta

College of Graduate Studies: Theses & Dissertations

This quasi-experimental study investigated the effect of a table-top roleplaying game (ttrpg), specifically Dungeons and Dragons™ (D&D), on increasing feelings of social connection, decreasing perceived stress, increasing self-esteem and improving adjustment to college among first semester, first year students. participants signed up to either the D&D group or the comparison group. D&D participants (n = 18) attended five one-hour weekly D&D sessions, meanwhile the comparison group (n = 10) went through their first semester of college with no intervention, but completed the study measures at the same points in time as the D&D participants. All participants completed measures of social …


Investigation Of Mechanically Fatigue Low-Frequency Energy Harvesting Effects On Isotropic Materials, Daniel J. Meade Jan 2024

Investigation Of Mechanically Fatigue Low-Frequency Energy Harvesting Effects On Isotropic Materials, Daniel J. Meade

College of Graduate Studies: Theses & Dissertations

This research project reports an exploratory investigation of energy harvesting effect on isotropic material that goes through low frequency mechanical fatigue. Energy harvesting is a growing field of study that can recycle ambient energy back into a system that would otherwise be lost. This is a significantly useful method for the ongoing energy crisis and provides an alternate route to design and upgrade systems to be more efficient and last longer than current system designs. However, it is time to investigate if there is any effect vibration-based energy harvesting has on the structure from which energy is being harvested. To …


Computational Analysis Of A Naca 0012 Straight Wing At Various Reynolds Numbers Approaching Stall, John E. Crowe Iii Jan 2024

Computational Analysis Of A Naca 0012 Straight Wing At Various Reynolds Numbers Approaching Stall, John E. Crowe Iii

College of Graduate Studies: Theses & Dissertations

As the capabilities and power of computational resources improve with each passing year, the implementation of simulation in the field of aerospace engineering also increases due to its increased efficiency, as it allows for reducing both time and resources. In this study, a computational method is created and tested for determining and visualizing the effect of increasing flow velocity on a NACA 0012 3D wing as it approaches and reaches stall. For this study, the flow over a NACA 0012 3D wing is simulated using a Reynolds-averaged Navier Stokes simulation at angles of attack of 6, 8, 10, 12, and …


Cultivation Of A Commercially Important Macroalga (Ulva Sp) For Polyculture Research In Coastal Georgia, Kyle Mundy Jan 2024

Cultivation Of A Commercially Important Macroalga (Ulva Sp) For Polyculture Research In Coastal Georgia, Kyle Mundy

College of Graduate Studies: Theses & Dissertations

The Georgia coast has shown great potential for large-scale oyster aquaculture, and the rate at which the sector has grown demands implementation of novel techniques to ensure sustainability and success in the face of climate change. One practice – integrated multi-trophic aquaculture (IMTA) or polyculture – is known to have positive effects on the health and quality of farmed organisms and the surrounding environment through low pH/alkalinity amelioration, while also being a unique and viable way for a farming operation to diversify its products. To date, there has been no such attempt at investigating or demonstrating macroalgae culture in Georgia. …


Resonant Ultrasound Spectroscopy(Rus) For Material Characterization Of Metal Am Parts, Malik Marks Jan 2024

Resonant Ultrasound Spectroscopy(Rus) For Material Characterization Of Metal Am Parts, Malik Marks

College of Graduate Studies: Theses & Dissertations

Additive manufacturing (AM) has revolutionized the manufacturing industry by offering flexibility, customization, and rapid prototyping capabilities. However, ensuring the quality and reliability of AM parts remains a significant challenge due to variations in material properties and process parameters. The NDE method used in this study is Resonant Ultrasound Spectroscopy (RUS). This method was used to evaluate and understand its ability to detect internal voids and defects. Dog-bone samples were made using the 316L stainless steel alloy which were fabricated by powder bed fusion (PBF) AM technique at different processing conditions and post processing conditions. These samples were tested to find …


Geoelectrical And Hydrochemical Characterization Of Submarine Groundwater Discharge In Florida Bay, Ifeanyi Emmanuel Eze Jan 2024

Geoelectrical And Hydrochemical Characterization Of Submarine Groundwater Discharge In Florida Bay, Ifeanyi Emmanuel Eze

College of Graduate Studies: Theses & Dissertations

Florida Bay, situated at the southern tip of Everglades National Park and underlain by the Miami Limestone formation, is an ecosystem of global significance. Over the past century, the bay has faced threats such as droughts, seagrass mortality, and hypersalinity. Despite various studies and management efforts, the dynamics of submarine groundwater discharge (SGD) in the region remain underexplored. Given that SGD plays a significant role in the chemical dynamics of coastal ecosystems, it warrants thorough investigation. This study aims to characterize the spatial and temporal patterns of SGD in Florida Bay by surveying three basins – Rankin, Whipray, and Rabbit …


Evaluation Of The Navy Shipshape Program At A Large Navy Military Treatment Facility: A Comprehensive Swot Analysis Approach, Nia Nur Maye Jan 2024

Evaluation Of The Navy Shipshape Program At A Large Navy Military Treatment Facility: A Comprehensive Swot Analysis Approach, Nia Nur Maye

College of Graduate Studies: Theses & Dissertations

The increasing problem of obesity among Navy service members (SMs) is a public health concern that impacts operational readiness and health risks. To combat obesity, the Navy has an official weight management initiative called ShipShape. This project aimed to conduct a Strengths, Weaknesses, Opportunities, and Threats (SWOT) analysis of ShipShape at a large Military Treatment Facility (MTF) in Portsmouth, Virginia. This program evaluation aimed to identify the internal and external factors that influenced the program's effectiveness to propose suggestions for improvement. Using quantitative and qualitative methods, the evaluation focused on conducting a paired t-test to analyze changes in Body Mass …


Implementation Of Cavity Vortex Generators To Mitigate Stall And Ice Accretion On The Naca 0012, Eric Pernell Jan 2024

Implementation Of Cavity Vortex Generators To Mitigate Stall And Ice Accretion On The Naca 0012, Eric Pernell

College of Graduate Studies: Theses & Dissertations

With the growing environmental concerns of international aviation carbon emissions are driven by the ever-increasing commercial aviation traffic. This study aims to increase the aerodynamic efficiency of the NACA 0012, by implementing cavity vortex generators with the intent to increase the effective stall angle without a substantial increase of drag. This study is performed with Reynolds Averaged Navier-Stokes (RANS) at a low Reynolds of 5.0E+04 with varying cavity depths along the leading edge. The depths study is placed at 10 percent cord at depths of 3, 5, and 10 percent cord. All cavity vortex generators effectively increased the stall angle …


Aeroelastic Phenomena Of Fixed-Wing Aircraft In Transonic And Supersonic Flows Using A Tightly-Coupled Computational Approach, John C. Havenar Jan 2024

Aeroelastic Phenomena Of Fixed-Wing Aircraft In Transonic And Supersonic Flows Using A Tightly-Coupled Computational Approach, John C. Havenar

College of Graduate Studies: Theses & Dissertations

Aeroelastic phenomena encountered during flight have considerable effects on the aerodynamic characteristics of fixed-wing aircraft. Transonic aeroelastic phenomena are often characterized by unique flow features which have complex ramifications for aircraft in transonic flight. Computational study of high-speed aeroelastic phenomena requires a fully-coupled aeroelastic algorithm. A series of wing designs are studied with a computational finite volume method solver accompanied by a finite element method solver for the calculation of structural deformation. The computational model for the flow field is validated with experimental data. Modeled flight conditions include transonic flows with bordering subsonic and supersonic cases included for completeness. The …


So Much Courage: Hemingway, War, And Rape, Tracie Nicolai Jan 2024

So Much Courage: Hemingway, War, And Rape, Tracie Nicolai

College of Graduate Studies: Theses & Dissertations

Weaving together Ernest Hemingway’s biography and literature with her own life, Tracie Nicolai analyzes the impact of Hemingway’s life and literature in the classroom and outside of it. War trauma is analyzed in relation to rape and its lasting effects, paralleling the impacts and the traumas that shape our philosophies and our lives. Nicolai explores how Hemingway wrote of war and his own injuries, and she discusses the distance evident between his own life experiences and his subsequent fiction writings. In separate vignettes in each chapter, Nicolai writes of her experience as a rape survivor and the lasting impact on …


Concentration Effects Of Ytterbium(Iii) Ions On The Physical, Structural, Thermal, And Optical Properties Of Barium Phosphate Glasses, Richard Amesimenu Jan 2024

Concentration Effects Of Ytterbium(Iii) Ions On The Physical, Structural, Thermal, And Optical Properties Of Barium Phosphate Glasses, Richard Amesimenu

College of Graduate Studies: Theses & Dissertations

Ytterbium(III)-doped glasses are widely known for their application in near-infrared (NIR) lasers and nowadays attract attention for solar spectral conversion in photovoltaic cells. In this study, the effects of ytterbium(III) concentration on the physical, structural, optical, and thermal characteristics of Yb-doped phosphate glasses were investigated. The glasses were synthesized using the melt-quenching technique with nominal compositions of 50P2O5:(50 – xBaO):xYb2O3 (x = 0, 0.5, 1.0, 2.0, 3.0 and 4 mol%). The properties were then examined by density and related parameters, X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), Fourier transform-infrared …


Detecting Bearing Race Defects With Inductive Magnetic Reluctance Sensors And Artificial Neural Networks, Collin Daly Jan 2024

Detecting Bearing Race Defects With Inductive Magnetic Reluctance Sensors And Artificial Neural Networks, Collin Daly

College of Graduate Studies: Theses & Dissertations

This work proposes a method of detecting physical damage to bearing races in a rotational assembly by means of magnetic reluctance sensors generating a signal from a rotating gear-tooth wheel. A nominally sinusoidal signal is generated based on the rotation of a gearwheel with regularly spaced voids and lands. Detection is based on the time variance of the signal periodically in relation to the gearwheel and the bearing damage. The purpose of this work is to propose a process to detect and classify bearing race defects using existing sensors and neural networks for hazardous area equipment applications.


Functional Monitoring For Run-Time Assurance Of A Real-Time Cyber Physical System, Matthew W. Gelber Jan 2024

Functional Monitoring For Run-Time Assurance Of A Real-Time Cyber Physical System, Matthew W. Gelber

Theses and Dissertations

As cyber-physical systems (CPS) become more integrated into everyday life, the security of these systems must also be considered during their development due to their ever-increasing importance. With the growth of physical components in the system, more autonomous control requirements, and increased dependence on proper functionality, verifying system safety and correct operation becomes increasingly difficult. CPS have become more complex through the combination of additional hardware and the resulting interconnected software in many layers, each requiring unique security solutions. One example of such a safety-critical CPS embedded system is the Flight Control System (FCS) of an Unmanned Aerial System (UAS). …


The Patient Experience Of Language Discordance And Interpreter Services In The Emergency Department, Keri L. Baker Jan 2024

The Patient Experience Of Language Discordance And Interpreter Services In The Emergency Department, Keri L. Baker

Theses and Dissertations

Background: Clear communication is critical to the interaction of a patient and medical provider. For non-English speaking patients, language discordance, described as the lack of proficiency in a shared language, with the medical team results in a poor patient experience and poor patient outcomes. The predominant solution to language discordance is the use of interpreter services, however these services are underused in the emergency department (ED). Studies examining underuse of interpreter services have primarily focused on the clinician and little is known about the patient’s influence on the use of interpreter services.

Methods: Semi-structured interviews were conducted with 12 Spanish-speaking …


Covid-19 Vaccine And Infection And The Relationship To Lichen Planus Flare-Ups: A Self-Reported Survey Study, Sara Kube Jan 2024

Covid-19 Vaccine And Infection And The Relationship To Lichen Planus Flare-Ups: A Self-Reported Survey Study, Sara Kube

Theses and Dissertations

Purpose: The aim of this study was to determine if there is an increased occurrence of oral lichen planus flare-ups after COVID-19 vaccination or infection.

Methods: An 11-item questionnaire was dispersed to patients with a diagnosis of oral lichen planus. The survey contained questions regarding the patient’s history of COVID-19 vaccination and infection as it relates subjective oral lichen planus flare-ups (i.e. oral redness, oral ulcerations, and/or oral pain/discomfort).

Results: Self-reported flares were significantly associated with whether or not vaccine side effects were also reported (p-value=0.0053). For those who reported experiencing side effects (tiredness, headache, muscle pain, chills, fever, nausea), …


Utilizing Hemoglobin Binding Kinetics And X-Ray Crystallography In Sickle Cell Disease Drug Development, Ahmed Alghamdi Jan 2024

Utilizing Hemoglobin Binding Kinetics And X-Ray Crystallography In Sickle Cell Disease Drug Development, Ahmed Alghamdi

Theses and Dissertations

ABSTRACT

UTILIZING HEMOGLOBIN BINDING KINETICS AND X-RAY CRYSTALLOGRAPHY IN SICKLE CELL DISEASE DRUG DEVELOPMENT

By Ahmed Alghamdi, M.Sc. in Medicinal Chemistry

A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science in Medicinal Chemistry at Virginia Commonwealth University.

Virginia Commonwealth University, 2024.

Director: Dr. Martin K. Safo Professor, Department of Medicinal Chemistry

Introduction: Sickle Cell Disease (SCD) is characterized by severe hemolytic anemia, recurrent painful crises, and chronic organ damage, posing significant challenges to patients' quality of life and longevity. While current FDA-approved therapies offer symptomatic relief, they do not address the underlying molecular …