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Studying More, Not Less: Rethinking Test Anxiety In Undergraduate Biology Courses, Kailey E. Reeves May 2026

Studying More, Not Less: Rethinking Test Anxiety In Undergraduate Biology Courses, Kailey E. Reeves

Honors Theses

This study investigates the relationships among test anxiety, study behaviors, and metacognitive evaluation in undergraduate biology courses. While prior research has established that study strategies and metacognition influence academic performance, less is known about how these factors interact with test anxiety in undergraduate Biology courses. Guided by the student approaches to learning (SAL) and metacognition frameworks, this study examines whether test anxiety is associated with the type and number of study strategies students use, as well as their ability to evaluate their own learning and preparedness. Using a convergent parallel mixed-methods design, data was collected from 205 students enrolled in …


The Impact Of Patient Navigation On The Hepatitis C Care Continuum In Underserved Populations: A Scoping Review, Deauntaye Jones May 2026

The Impact Of Patient Navigation On The Hepatitis C Care Continuum In Underserved Populations: A Scoping Review, Deauntaye Jones

Honors Theses

Hepatitis C virus (HCV) remains a significant public health concern and is a leading cause of cirrhosis, hepatocellular carcinoma, and liver transplantation when left untreated. Although direct-acting antiviral therapies have made HCV curable for most patients, many underserved populations continue to experience barriers to diagnosis, linkage-to-care, treatment completion, and sustained virologic response (SVR). This study evaluated how patient navigation programs influence progression through the HCV care continuum among underserved populations. Relevant studies published between 2014 and 2025 were identified through searches of PubMed and Embase using terms related to HCV, patient navigation, linkage-to-care, underserved populations, and treatment outcomes. Following title, …


Hyposense: Multimodal Physiologic And Voc Wearable For Early Hypoglycemia Detection, Nidhi R. Patel May 2026

Hyposense: Multimodal Physiologic And Voc Wearable For Early Hypoglycemia Detection, Nidhi R. Patel

Honors Theses

Hypoglycemia remains a significant safety concern for insulin-dependent individuals, especially when blood glucose declines rapidly during exercise, sleep, or periods of impaired hypoglycemia awareness. Current continuous glucose monitors and automated insulin delivery systems have helped to improve diabetes management, but these technologies primarily respond to glucose trends after they have already started and may not actually provide sufficient warning before symptoms occur. This thesis describes the development of HypoSense, a noninvasive wrist worn wearable concept that is designed to support earlier hypoglycemia risk detection through multimodal physiologic and volatile organic compound emission sensing. HypoSense combines volatile organic compounds/gas sensing with …


Learning Through Play: The Effects Of Play-Based Instruction On Literacy Development, Jherica Goodgame May 2026

Learning Through Play: The Effects Of Play-Based Instruction On Literacy Development, Jherica Goodgame

Honors Theses

This thesis explores the role of play-based learning in early literacy development, emphasizing its impact on student engagement, executive functioning, and overall academic success. Drawing from research and personal experience, it argues that play is not separate from learning but a critical component of it. This thesis also highlights the benefits of play for diverse learners and examines the challenges teachers face in implementing play-based instruction. It provides numerous examples of play-based instruction practiced in a real classroom setting with 17 students who are varying from early kindergarten to late kindergarten levels. This thesis seeks to demonstrate the importance of …


The Influence Of The Federalist Society On Originalism In Supreme Court Opinions, Edoardo Santopuoli May 2026

The Influence Of The Federalist Society On Originalism In Supreme Court Opinions, Edoardo Santopuoli

Honors Theses

This thesis will investigate the influence of the Federalist Society on the use of originalism in Supreme Court opinions. To investigate this influence, justices that served on the Supreme Court from 1994 to 2022 are categorized based on whether or not they are affiliated with the Federalist Society. Then using artificial intelligence (ChatGPT version 5.3), ten Supreme Court opinions known to be originalist are used as a baseline for artificial intelligence to know what an originalist opinion looks like. Then, all majority opinions of the Supreme Court from that timeframe are scored from 1-10, with 10 meaning an opinion is …


Identity, Masculinity, And Stigma: Understanding Barriers To Mental Health Care Among African American Men, Landon H. Jones May 2026

Identity, Masculinity, And Stigma: Understanding Barriers To Mental Health Care Among African American Men, Landon H. Jones

Honors Theses

African American men are documented to underutilize health care services. Although the reasons for this pattern are complex, research suggests that both historical mistrust of the medical system and sociocultural expectations of strength, rooted in intersecting racial and masculine identities, might play key roles. These same factors may also influence attitudes toward mental health care. In the study, 267 African American men were randomly assigned to listen to a brief pro-health message delivered by either an in-group community member, a religious figure, or a neutral control speaker. Participants completed measures of racial identity importance, conformity to masculine norms, anticipated stigma, …


Just War Theory And Coercive Non-Proliferation: Ethically Evaluating Nuclear Prevention Efforts, P. Walker Jacklin May 2026

Just War Theory And Coercive Non-Proliferation: Ethically Evaluating Nuclear Prevention Efforts, P. Walker Jacklin

Honors Theses

This thesis examines the ethics of coercively addressing non-nuclear states who are attempting to acquire nuclear weapons. Nuclear weapons pose a serious danger on a global scale, so ethical analysis should balance these consequences with the coerciveness of state intervention. Just War Theory provides a useful framework that balances these considerations.  Using the criteria of Just War Theory, this thesis examines two 21st century non-proliferation operations: Operation Orchard and Operation Midnight Hammer. I find that Operation Orchard fails the criteria of Just War Theory, while Operation Midnight Hammer satisfies the criteria. Making this determination is ethically risky, however, because our …


Mechanisms Underlying Diversity In Bacterial Biofilms, Jacob David Holt May 2026

Mechanisms Underlying Diversity In Bacterial Biofilms, Jacob David Holt

Dartmouth College Ph.D Dissertations

Bacteria commonly exist in natural environments as communities of multiple strains and species attached to surfaces and encased in an extracellular matrix of DNA, protein, and polysaccharides–termed biofilms. These biofilms contribute to diverse functions, from ocean carbon cycling via chitin degradation to pathogenic processes such as wound or implant colonization. The molecular mechanisms governing biofilm formation and composition have been well characterized in model pathogenic organisms, yet the extent to which aspects of biofilm formation contribute to the assembly and maintenance of diverse communities remains less well understood. Using microfluidics, confocal microscopy, and model biofilm-forming bacteria, this thesis details how …


Tensions, Characteristics, And Methods Surrounding Critical Autoethnographic Narrative: A Dialogic Review Of Bedrettin Yazan’S Autoethnography In Language Education, Meryem Büşra Ünsal, Ufuk Keleş May 2026

Tensions, Characteristics, And Methods Surrounding Critical Autoethnographic Narrative: A Dialogic Review Of Bedrettin Yazan’S Autoethnography In Language Education, Meryem Büşra Ünsal, Ufuk Keleş

The Qualitative Report

In this book review, the authors critically explore Bedrettin Yazan’s Autoethnography in Language Education, which addresses theoretical, methodological, and ethical dimensions of autoethnography in applied linguistics and teacher education. Organized as a reconstructed scholarly dialogue between a doctoral advisor - Ufuk, and a doctoral researcher - Meryem, the review systematically outlines the book’s central arguments, chapter structure, and contributions to qualitative research. Attention is given to Yazan’s positioning of autoethnography as an onto-ethico-epistemological stance, his engagement with debates surrounding legitimacy and rigor, and his discussion of reflexivity, identity, and emotional labor in research. The review also highlights the book’s practical …


Building Ai Literacy Through Assessment Practices In Physical Education Teacher Education, Rebekah A. Johnson May 2026

Building Ai Literacy Through Assessment Practices In Physical Education Teacher Education, Rebekah A. Johnson

Educational Practices in Kinesiology

The classroom resource presented provides an instructional approach designed to enhance both course outcomes and artificial intelligence (AI) literacy in undergraduate physical education preservice teachers. Implemented in a full-semester, in-person Assessment in Physical Education course, the project engaged students in learning to develop effective AI prompts, critically analyze AI-generated outputs, and apply these tools to design a standards-based assessment plan. Designed for undergraduate students with foundational knowledge of assessment and pedagogy, the project incorporated scaffolded tasks, guided discussions, and structured reflections to support AI integration through experiential learning. In approximately 30 minutes per week throughout the semester, students explored how …


Design And Production Of A Carbon Fiber Longboard, Jacob T. Williams May 2026

Design And Production Of A Carbon Fiber Longboard, Jacob T. Williams

Honors Theses

This thesis contains an overview of the design, prototyping, and manufacturing of a carbon fiber long board. The purpose of this capstone was to create a viable product for the real-world market and then determine how to manufacture it at scale with sustainable financial practices. In order to accomplish this task, engineering, accounting, and manufacturing challenges had to be overcome throughout all stages. The production process involved the carbon fiber layup, baking, water jet cutting, and assembly of the carbon fiber longboard. In order to optimize this process, continuous improvement and lean manufacturing problem solving techniques were applied. After a …


"En Papel,” Not In Practice: Indigenous Autonomy And The Structural Barriers To Land And Resource Control In Bolivia, Andrew F. Purcell May 2026

"En Papel,” Not In Practice: Indigenous Autonomy And The Structural Barriers To Land And Resource Control In Bolivia, Andrew F. Purcell

Honors Theses

This thesis examines why Bolivia’s 2009 plurinational constitution—despite its strong recognition of Indigenous autonomy, collective territory, and prior consultation—often produces rights that remain “en papel” rather than in practice. Based on one month of fieldwork in Tumupasa, Chojasivi, La Paz, El Alto, and Santa Cruz, the study draws on interviews, participant observation, and NGO documents to analyze the structural barriers that prevent constitutional guarantees from becoming enforceable governance tools. This gap between recognition and implementation structures the central research question: why do Bolivia’s constitutional and legal protections for indigenous land and resource rights function as symbolic guarantees rather than enforceable …


Stridevision: Automated Detection Of Running Form Deviations From 2d Pose Estimation And Machine Learning, Paulina Eguibar Ortega May 2026

Stridevision: Automated Detection Of Running Form Deviations From 2d Pose Estimation And Machine Learning, Paulina Eguibar Ortega

Honors Theses

Running gait analysis plays a critical role in injury prevention and performance optimization, however, existing approaches often rely on specialized laboratory equipment or wearable sensors with limited interpretability. Recent advances in computer vision, particularly 2D human pose estimation, enable markerless motion analysis from standard video. However, progress remains constrained by the lack of publicly available datasets designed for running form analysis.

In this work, we introduce a preliminary dataset and benchmark for stride-level running gait analysis. The dataset consists of 73 treadmill running videos from 15 participants with varying experience levels, annotated with over 4,600 stride-level labels across multiple biomechanical …


Analyzing Best Practices In Large-Scale Digital Archaeological Databases, Chloe M. Vizier May 2026

Analyzing Best Practices In Large-Scale Digital Archaeological Databases, Chloe M. Vizier

Honors Theses

Archaeological databases, the foundation of archaeological analyses, have changed drastically alongside the rise of new digital tools in the twenty-first century. Digital databases, alongside other digital tools, must therefore be evaluated for their efficiency and effectiveness within the field. This thesis seeks to determine a set of best practices within large-scale digital archaeological databases through analyzing an existing example: The Paleoindian Database of the Americas (PIDBA). PIDBA is composed of multiple state-level datasets, a trait that both invited collaboration and creates discrepancies in data entry. Though examining both PIDBA's user-facing website and one of its most robust state-level datasets, the …


Evolution Of Nematode Prey Chemotaxis Behavior Across Different Environments, Hailey R. Smith May 2026

Evolution Of Nematode Prey Chemotaxis Behavior Across Different Environments, Hailey R. Smith

Honors Theses

Climatic conditions in the near future are projected to be warmer, with more frequent and intense weather events. This will substantially alter the environments in which organisms must integrate specific information to find essential resources. Many organisms rely upon chemical signals to orient towards attractive resources through a mechanism called chemotaxis. How different environmental conditions, like temperature, impact this process will be important to understand as environments change. I conducted a laboratory evolution experiment with the model nematode Caenorhabditis elegans to see how success in chemotaxis assays changes over time when selected under different temperature regimes (normal laboratory temperature, increased …


Re: Conditional Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) Clark Tailings Consolidated Waste Management Area (Ctcwma) Site Investigation Quality Assurance Project Plan (Qapp) (Dated April 16, 2026), Emma Rott May 2026

Re: Conditional Approval Letter For The Butte Priority Soils Operable Unit (Bpsou) Clark Tailings Consolidated Waste Management Area (Ctcwma) Site Investigation Quality Assurance Project Plan (Qapp) (Dated April 16, 2026), Emma Rott

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.


Draft Final Butte Mine Waste Repository Operation And Maintenance (O&M) Plan, Pioneer Technical Services, Inc. May 2026

Draft Final Butte Mine Waste Repository Operation And Maintenance (O&M) Plan, Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.


Values-Based Clinical Ethics: A New Model Of Health And Ethics Consultation For Patients Suffering In Extremis, Adam Trainer May 2026

Values-Based Clinical Ethics: A New Model Of Health And Ethics Consultation For Patients Suffering In Extremis, Adam Trainer

Electronic Theses and Dissertations

This dissertation argues that contemporary clinical ethics is inadequately equipped to support patients suffering in extremis because it relies on an insufficiently discriminating account of health and a constrained model of moral reasoning. Drawing on Bernard Lonergan, it reconceives health as an emergent, multi-layered, heuristic notion shaped by biological, psychological, social, and existential goods. On that basis, it critiques principlism’s global applicability thesis and the undergirding claim that its principles form part of the common morality, arguing that this justificatory structure is philosophically insufficient and practically limited for clinical ethics in cases marked by profound suffering, moral plurality, and normative …


The Design And Manufacturing Process Of The Concealed Shelf, Mexrojiddinbek Sattorov May 2026

The Design And Manufacturing Process Of The Concealed Shelf, Mexrojiddinbek Sattorov

Honors Theses

This document contains information regarding the design and build process of the Concealed Shelf, which is a furniture product with hidden storage capability. First, the team members decided on the design of the product, followed by market analysis and manufacturing feasibility. Lean manufacturing principles were applied to improve the process efficiency and reduce waste.

Multiple prototypes were built with varying raw materials and locking mechanisms. Jigs and fixtures were handcrafted to ensure more consistent product quality. Two production runs were conducted to evaluate performance and identify areas for improvement.

The final design includes economic considerations, manufacturing layout, and continuous improvement …


Energy Materials Health Monitoring With Interpretable Machine Learning, Osumanu Musah Mohammed May 2026

Energy Materials Health Monitoring With Interpretable Machine Learning, Osumanu Musah Mohammed

Honors Theses

Reliability and the lifecycle of energy materials have become key concerns for sustainable, decarbonized power systems [1]. More recent reports on photovoltaic (PV) device technologies, fuel cells, hydrogen storage, and novel composite materials have indicated that material deterioration is a constraint on large-scale exploitation and cost-effectiveness, rather than on energy conversion efficiency [2], [3]. The energy infrastructure of tomorrow needs to be smart and efficient; however, more to the point, it needs to be self-aware, self-diagnostic, and able to overcome any form of degradation before breaking down [4]. The US dilemma is also directly related to federal concerns. That is …


Recovering Sn From Ultrafine Tails At Mina San Rafael, Peru, Angelica Plenge May 2026

Recovering Sn From Ultrafine Tails At Mina San Rafael, Peru, Angelica Plenge

Honors Theses

San Rafael is currently the only mine producing tin (Sn) in Peru, operating two concentrators. In the first, called the San Rafael plant, tin concentrate is produced through gravity separation circuits consisting of jigs, spirals, and Mozley tables, followed by reverse flotation, where sulfides are floated while cassiterite (78.77% theoretical tin content) is depressed. Material containing tin values is then directed to a desliming circuit, where the pulp density is adjusted prior to sulfide reverse flotation. The tailings from this stage are subsequently processed through another flotation circuit but, in this case, the Sn is floated. Cycloning is applied throughout …


Integrating Remote Sensing Soil Water Balance And Time-Lapse Microgravity To Quantify A Groundwater Budget For The Greenfields Bench Aquifer, Montana, Tyler Storey May 2026

Integrating Remote Sensing Soil Water Balance And Time-Lapse Microgravity To Quantify A Groundwater Budget For The Greenfields Bench Aquifer, Montana, Tyler Storey

Honors Theses

The Greenfields Bench is an irrigation-sustained, shallow, unconfined gravel aquifer in Teton County, Montana, where irrigation modernization and canal operations affect groundwater recharge, storage, and discharge to drains and streams. This study integrates a 30 m remote sensing soil water balance in Google Earth Engine using OpenET evapotranspiration and gridded climate inputs (2020 to 2024) with a two-epoch time-lapse microgravity survey (July and November 2025), groundwater-level measurements, Greenfields Irrigation District operational records, and U.S. Geological Survey streamflow observations to quantify irrigation water partitioning and develop a groundwater budget. Microgravity paired with water level change yields provisional, high-uncertainty, effective specific yield …


Hydrogen Engine For A Continuous Biochar Reactor, Andrew Woods May 2026

Hydrogen Engine For A Continuous Biochar Reactor, Andrew Woods

Honors Theses

A biochar reactor produces biochar, syngas, and bio-oil, which can be utilized for many useful products that are used in environmental remediation and power generation. The hydrogen that is captured from the syngas during the thermochemical gasification process opens the door to a unique opportunity to provide green energy from a biomass feedstock. The research aims to incorporate a single-cylinder, 10-hp engine that has been converted from gasoline to hydrogen fuel into a continuous biochar production reactor. This will play the role of power generation in a larger system that intends to mobilize biochar production. This study focuses on the …


Optimization And Safety Protocols For An Acetone Production Plant, Holley J. Garrison May 2026

Optimization And Safety Protocols For An Acetone Production Plant, Holley J. Garrison

Honors Theses

The proposed acetone production plant, scheduled for start-up in 2028, is capable of producing 3,750 kg/h of 99.9 wt% acetone. Using an endothermic catalytic dehydrogenation reaction, a feed of isopropyl alcohol (IPA) is reacted to produce 30,000 metric tons per year (MT/y) of acetone. Initial design and economic analysis of this process found that this plant will not be economically viable due to its Net Present Value (NPV) of -$132M. Optimization efforts prioritized reductions in raw materials and improved product recovery. Several optimizations were performed to reduce the feed rate, including switching to the low temperature catalyst, shortening the reactor …


Identifying Novel Gene Dysregulation Associated With Opioid Overdose Death: A Meta-Analysis Of Differential Gene Expression In Human Prefrontal Cortex, Javan K Carter, Bryan C Quach, Caryn Willis, Melyssa S Minto, Dana B Hancock, Janitza Montalvo-Ortiz, Olivia Corradin, Ryan W Logan, Consuelo Walss-Bass, Brion S Maher, Eric Otto Johnson May 2026

Identifying Novel Gene Dysregulation Associated With Opioid Overdose Death: A Meta-Analysis Of Differential Gene Expression In Human Prefrontal Cortex, Javan K Carter, Bryan C Quach, Caryn Willis, Melyssa S Minto, Dana B Hancock, Janitza Montalvo-Ortiz, Olivia Corradin, Ryan W Logan, Consuelo Walss-Bass, Brion S Maher, Eric Otto Johnson

Faculty, Staff and Student Publications

Only recently have human postmortem brain studies of differential gene expression (DGE) associated with opioid overdose death (OOD) been published; sample sizes from these studies have been modest (N = 40-153). To increase statistical power to identify OOD-associated genes, we leveraged human prefrontal cortex RNA-seq data from four independent OOD studies and conducted a transcriptome-wide DGE meta-analysis (N = 272). Using a unified gene expression data processing and analysis framework across studies, we meta-analyzed 20, 098 genes and found 335 significant differentially expressed genes (DEGs) by OOD status (false discovery rate <  0.05). Of these, 66 DEGs were among the list of 303 genes reported as OOD-associated in prior prefrontal cortex molecular studies (e.g., genes/gene families OPRK1, NPAS4, DUSP, EGR). The remaining 269 DEGs were not previously reported (e.g., NR4A2, SYT1, HCRTR2, BDNF). There was little evidence of genetic drivers for the observed differences in gene expression between opioid addiction cases and controls. Enrichment analyses for the DEGs across molecular pathway and biological process databases highlight an interconnected set of genes and pathways linked to orexin and tyrosine kinase receptors through MEK/ERK/MAPK signaling to affect neuronal plasticity.


Conscientiousness And Collegiate Athletes: An Item Response Theory Analysis, Tyler Hall May 2026

Conscientiousness And Collegiate Athletes: An Item Response Theory Analysis, Tyler Hall

College Honors Program

The purpose of this study is to examine how the facets (Kitchenham, L. et al., 2019) and aspects (Roberts et al., 2005) of conscientiousness influence collegiate athletes and how this understanding can be applied to the development of athletes and coaches. Like everyone else, student-athletes face daily stressors that can hinder their performance both in the classroom and on the field. Personality traits play a significant role in an individual's ability to manage these stressors (Lopes Dos Santos, M., 2020). This study examined conscientiousness, one of the Big Five Personality Traits defined by McCrae and Costa (1986), which is characterized …


Spad Camera Image Analysis, Pratheen Reddy Pininti May 2026

Spad Camera Image Analysis, Pratheen Reddy Pininti

Electronic Theses and Dissertations 2020 - Present

I present a thorough noise characterization of the Canon MS-500, a Single-Photon Avalanche Diode (SPAD) camera system, tested under both lit and dark conditions. The camera outputs 10-bit digital number (DN) values produced by an internal processing pipeline whose design is not publicly documented. All analyses in this thesis therefore describe the camera’s DN output — the signal that any downstream detection, tracking, or classification system will actually receive — rather than the photon-counting statistics of the underlying SPAD array. All computations were performed on the native 10-bit data. Where a measured quantity has a known photon-counting analog, the relationship …


Enhancing Psychiatry Residents’ Knowledge And Comfort With Clozapine Prescribing Through Educational Interventions, Christopher Stewart, Alexander Hunter, Faith Franzwa, Quan Huynh, Jennifer Stettler, Nauman Ashraf, Dawny M. Barnhart May 2026

Enhancing Psychiatry Residents’ Knowledge And Comfort With Clozapine Prescribing Through Educational Interventions, Christopher Stewart, Alexander Hunter, Faith Franzwa, Quan Huynh, Jennifer Stettler, Nauman Ashraf, Dawny M. Barnhart

Student Publications

Introduction: Clozapine is the most effective antipsychotic for treatment-resistant schizophrenia but remains underutilized due to safety concerns and monitoring complexity. Recent discontinuation of the Clozapine Risk Evaluation and Mitigation Strategy (REMS) program reduced regulatory barriers but shifted responsibility for monitoring to clinicians. Psychiatry residents may lack adequate training and confidence to prescribe clozapine safely in this new context. The goal of this study is to evaluate the impact of a structured educational intervention on psychiatry residents’ knowledge of clozapine prescribing and management.

Methods: This study was a single-institution quality improvement study using a pre-post design. Participants were psychiatry residents from …


Social Prescribing For Refugee Populations: A Rapid Realist Review Of International Evidence, Victoria Touzel, Doreen Reifegerste, Luisa Bartz, Anna-Lena Esser, Kerryn Husk May 2026

Social Prescribing For Refugee Populations: A Rapid Realist Review Of International Evidence, Victoria Touzel, Doreen Reifegerste, Luisa Bartz, Anna-Lena Esser, Kerryn Husk

Peninsula Medical School

BackgroundSocial prescribing offers potential for addressing social determinants of health and supporting health equity among disadvantaged groups. However, evidence for refugee populations remains limited, despite this group facing profound social and systemic barriers. This rapid realist review synthesizes social prescribing and comparable social-capital based intervention evidence to address this gap.MethodsWe conducted a RAMESES-compliant rapid realist review supported by an expert advisory board. Searches across six databases (2014–2024) were supplemented by grey literature and citation chasing strategies. Eligible studies included refugee, asylum-seekers and forcibly displaced populations engaged in either formal social prescribing or comparably operationalized social-capital interventions. Synthesis developed Context-Mechanism-Outcome configurations …


Inflammatory Markers In The Emergency Department And Ptsd Symptoms In The Aurora Study: A Longitudinal Cohort Study, Kristen Nishimi, Sarah Linnstaedt, Thomas Neylan, Lauren Mckibben, Liz Marie Albertorio-Sáez, Ying Zhao, Stacey House, Francesca Beaudoin, Xinming An, Jennifer Stevens, Gari Clifford, Tanja Jovanovic, Laura Germine, Scott Rauch, John Haran, Alan Storrow, Paul Musey, Phyllis Hendry, Sophia Sheikh, Brittany Punches, Robert Swor, Jose Pascual, Mark Seamon, Elizabeth M Datner, Claire Pearson, David Peak, Roland Merchant, Robert Domeier, Niels Rathlev, Brian O'Neil, Paulina Sergot, Leon Sanchez, Steven Bruce, Steven Harte, Ronald Kessler, Karestan Koenen, Kerry Ressler, Samuel Mclean, Aoife O'Donovan May 2026

Inflammatory Markers In The Emergency Department And Ptsd Symptoms In The Aurora Study: A Longitudinal Cohort Study, Kristen Nishimi, Sarah Linnstaedt, Thomas Neylan, Lauren Mckibben, Liz Marie Albertorio-Sáez, Ying Zhao, Stacey House, Francesca Beaudoin, Xinming An, Jennifer Stevens, Gari Clifford, Tanja Jovanovic, Laura Germine, Scott Rauch, John Haran, Alan Storrow, Paul Musey, Phyllis Hendry, Sophia Sheikh, Brittany Punches, Robert Swor, Jose Pascual, Mark Seamon, Elizabeth M Datner, Claire Pearson, David Peak, Roland Merchant, Robert Domeier, Niels Rathlev, Brian O'Neil, Paulina Sergot, Leon Sanchez, Steven Bruce, Steven Harte, Ronald Kessler, Karestan Koenen, Kerry Ressler, Samuel Mclean, Aoife O'Donovan

Department of Emergency Medicine Faculty Papers

BACKGROUND: Systemic inflammation is hypothesized to contribute to post-traumatic stress disorder (PTSD) vulnerability. Few studies have examined inflammation shortly after trauma as a predictor of later PTSD symptoms. We examined whether inflammation from the emergency department (ED) post-trauma is associated with PTSD symptom severity over the following 6 months.

METHODS: Our sample included 742 AURORA participants, a longitudinal cohort of patients in 29 EDs across the United States after a traumatic stressor, followed up to 6 months. Plasma cytokines were assessed from a study blood draw in the ED: an inflammatory index (standardized sum of generally pro-inflammatory markers interleukin [IL]-6, …