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Articles 89401 - 89430 of 1517301
Full-Text Articles in Entire DC Network
Providing Safe Gastric Feedings In Pediatric Patients On High Flow Nasal Cannula Respiratory Support, Olivia Joyce Chan
Providing Safe Gastric Feedings In Pediatric Patients On High Flow Nasal Cannula Respiratory Support, Olivia Joyce Chan
Yale School of Nursing Digital Theses
Purpose: HFNC is used to manage pediatric respiratory distress, but concerns aboutgastric air insufflation and aspiration risk lead to delayed feedings. There is no standardized practice guiding gastric feedings in children on HFNC. This project developed and implemented a decision tree to guide clinical decision-making for gastric feedings for children on HFNC. Methods: A HFNC feeding safety decision tree was developed following literature review and implemented in a Pediatric Intensive Care Unit (PICU). The primary outcome evaluated HFNC flow rates when starting gastric feeds. Secondary outcomes include adverse events (AEs), physiologic distress, and PICU/hospital LOS. Data were analyzed using Chi-Square …
Changing The Paradigm For Newly Graduated Nurses’ Intent To Leave Through An Emeritus Rn Virtual Mentoring Program In An Acute Care Hospital Setting, Lacy Eynon
Yale School of Nursing Digital Theses
The U.S. nursing shortage presents a critical challenge to healthcare organizations, withwide-reaching implications for patient safety and financial sustainability. High nurse turnover contributes to increased staffing costs, estimated at $56,300 average cost per nurse replaced. This shortage directly impacts patient outcomes including increased rates of medical errors, patient mortality and decreased overall quality of care. Supporting early-career nurses through mentorship programs is a promising strategy to improve professional development and retention, thereby addressing clinical and economic consequences workforce shortages. This DNP Project developed and implemented an Emeritus RN Virtual Mentoring Program utilizing experienced emeritus nurses to mentor nurses with less …
Empowering Emerging Air Medical Leaders Through A Novel Professional Development Program Adapting National Nursing And Healthcare Management Competencies To A Multi-State Air Medical Service, Christopher Hardman
Yale School of Nursing Digital Theses
Empowering Emerging Air Medical Leaders through a Novel Professional Development Program Adapting National Nursing and Healthcare Management Competencies to a Multi-State Air Medical ServiceHigh turnover in the nursing workforce has led to clinicians with limited experience being promoted to leadership roles without proper training or support. Nurse leaders directly impact clinical outcomes and retention. The financial burden of turnover is significant, as health systems must continually replace employees. Despite this, limited evidence exists on effective professional development and retention strategies in non-traditional, non-hospital settings. This DNP project sought to adapt and implement a novel professional development program, derived from the …
Transgender And Gender Diverse People – Inclusive Healthcare System Access, Dakota Denielle Lawtum
Transgender And Gender Diverse People – Inclusive Healthcare System Access, Dakota Denielle Lawtum
Yale School of Nursing Digital Theses
Transgender and Gender Diverse People – Inclusive Healthcare System AccessPurpose: This DNP project implemented a dual strategy to increase system-wide access to care and awareness of the needs of transgender and gender diverse people. Background: The 2015 U.S. Transgender Survey is the most recent and largest survey of its kind in the United States comprising a total of 27,715 responses. (National Center for Transgender Equality, 2015, U.S. Transgender Survey). The results of this survey are as follows: 1) 26% of the total national respondents experienced insurance issues for gender affirming healthcare or being denied coverage for routine care; 2) 32% …
Developing A Decision Tree To Address Behavioral And Psychological Symptoms Of Dementia In The Primary Care Setting, Lolita Tramel
Developing A Decision Tree To Address Behavioral And Psychological Symptoms Of Dementia In The Primary Care Setting, Lolita Tramel
Yale School of Nursing Digital Theses
AbstractDeveloping a Decision Tree to Address Behavioral and Psychological Symptoms of Dementia in the Primary Care Setting There are 55 million people living with dementia worldwide. In the United States, there are approximately 7.2 million people living with Alzheimer’s dementia and these numbers are expected to rise. The U.S. Department of Health and Human Services (2022) identified there is a shortage of behavioral health clinicians nationwide. As the population ages, demand for behavioral health clinicians will be high and supply will remain low. Primary care providers (PCPs) will be required to see an influx of dementia patients despite finding it …
Live Streaming In Hospitality And Tourism: A Hybrid Systematic Review And Way Forward, Yuhong Shao, Songshan (Sam) Huang
Live Streaming In Hospitality And Tourism: A Hybrid Systematic Review And Way Forward, Yuhong Shao, Songshan (Sam) Huang
Research outputs 2022 to 2026
Purpose: This study aims to provide a timely review of hospitality and tourism live streaming (HTLS) research, aiming to understand the intellectual foundation in the past and identify opportunities for future research. Design/methodology/approach: This study collected 56 papers from journals in the Social Science Citation Index database or the Australian Business Deans Council journal quality list and adopted a hybrid systematic literature review combining bibliometric analysis and the theory-context-characteristics-method framework-based approach. Additionally, a cross-tabulation analysis was conducted to compare the research on two specific forms of HTLS – tourism e-commerce live streaming (TEcLS) and travel live streaming. Findings: The study …
Using Online Critical Reflection To Enhance Students’ Confidence, Motivation, And Engagement In Higher Education, Isaiah T. Awidi, Jonas Quashie Klutsey
Using Online Critical Reflection To Enhance Students’ Confidence, Motivation, And Engagement In Higher Education, Isaiah T. Awidi, Jonas Quashie Klutsey
Research outputs 2022 to 2026
This research examines the effect of critical reflection activities in an educational environment that uses active and blended learning experiences for students to develop confidence, motivation, and engagement with their learning. A mixed-methods research approach was adopted on a sample of 137 Communications and Media students, who were involved in a game-based project. Using a validated survey instrument to measure the students’ perceptions of their experiences, Pearson Correlation coefficient was used to estimate the relationship between the learning activities and students’ perceived confidence, motivation, and engagement. Finally, multiple linear regression was used to determine the effect of the critical reflection …
Myopia Correction, Myopia Control And Myopia Management: Definitions And Recommended Usage, International Myopia Institute (Imi), Ian Flitcroft, Mark A. Bullimore, Kate L. Gifford, Jost B. Jonas, Deborah Jones, Lyndon W. Jones, Pauline Kang, Serge Resnikoff, Jeffrey Walline, Christine F. Wildsoet
Myopia Correction, Myopia Control And Myopia Management: Definitions And Recommended Usage, International Myopia Institute (Imi), Ian Flitcroft, Mark A. Bullimore, Kate L. Gifford, Jost B. Jonas, Deborah Jones, Lyndon W. Jones, Pauline Kang, Serge Resnikoff, Jeffrey Walline, Christine F. Wildsoet
Research Outputs: 2025-Present
No abstract provided.
Bragg Compensated Non-Normal Incidence Hoe Fabrication For Occlusion Capable Near Eye Display, Chun Wei Ooi, Dipanjan Chakraborty, Owen Kearney, Izabela Naydenova, John Dingliana, Suzanne Martin
Bragg Compensated Non-Normal Incidence Hoe Fabrication For Occlusion Capable Near Eye Display, Chun Wei Ooi, Dipanjan Chakraborty, Owen Kearney, Izabela Naydenova, John Dingliana, Suzanne Martin
Research Outputs: 2025-Present
volume Holographic Optical Elements (VHOE) are being developed for use in image combiners and waveguide couplers within the near eye display(NED). VHOEs have the potential to replace conventional geometric optics and can perform multiple functions in a lightweight thin layer, depending on the recorded hologram design. However, due to high dispersion and the angular and spectral selectivity of VHOEs, bespoke solutions are needed for every new system design and it is important to be able to fabricate at a given recording wavelength (with available lasers) regardless of the intended operating wavelength of the VHOE. To alleviate the problem, we have …
Imi—2025 Digest, Nina Tahhan, Mark A. Bullimore, Xiangui He, Lisa A. Ostrin, Timothy J. Gawne, Kate L. Gifford, Pauline Kang, Ian Morgan, Aude Couturier, Kyoko Ohno-Matsui, Nicola S. Logan, Ian Flitcroft
Imi—2025 Digest, Nina Tahhan, Mark A. Bullimore, Xiangui He, Lisa A. Ostrin, Timothy J. Gawne, Kate L. Gifford, Pauline Kang, Ian Morgan, Aude Couturier, Kyoko Ohno-Matsui, Nicola S. Logan, Ian Flitcroft
Research Outputs: 2025-Present
As myopia research expands in scope and complexity, the International Myopia Institute (IMI) continues to provide timely, evidence-based consensus guidance through its biennial white papers and digests. The IMI 2025 Digest delivers targeted updates in areas identified for revision since the previous digest: definitions and classification of myopia, clinical management guidelines, risk factors, accommodation and binocular vision, experimental models, and onset and progression in young adults. A major focus is the evolving concept of pre-myopia, including a refined understanding of hyperopic reserve as a predictive marker, population-specific thresholds, and the distinction between risk and predictive factors. Emerging evidence supports earlier …
Property And Information, Jeanne L. Schroeder, David G. Carlson
Property And Information, Jeanne L. Schroeder, David G. Carlson
Articles
The article proceeds as follows. As the information theory is a reaction to legal realism, Part I explores its antecedents in the work of Wesley Newcomb Hohfeld and Ronald H. Coase. Part II presents the information theory as arising from Professor Smith’s interpretation of the Coase theorem.11 In the imaginary world of TC0, we are supposedly indifferent to organizing by property and organizing by contract. Property eclipses contract as the organon of the economy because property reduces the cost of delineation and processing—of speaking and comprehending. We show that this theory is founded on a misunderstanding of Coase. Part III …
A Proposed Load Forecasting Strategy Developed On Smart Electrical Grid Employing Deep Learning Techniques, Noha A. Sakr, Ahmed I. Saleh, Rana Mohamed El-Balka
A Proposed Load Forecasting Strategy Developed On Smart Electrical Grid Employing Deep Learning Techniques, Noha A. Sakr, Ahmed I. Saleh, Rana Mohamed El-Balka
Mansoura Engineering Journal
Smart electrical grids, which involve the application of intelligent information and communication technologies, are becoming the core ingredient in the ongoing modernization of the electricity delivery infrastructure. They enable the real-time monitoring and direction of network components, which has led to the emergence of new jobs and responsibilities including autonomous intelligent load forecasting. As it gives energy management intelligence, load forecasting is a crucial function for the operation and planning of the electrical system. Many works and studies have been made over the years to enhance smart grids, almost all of these works target the data collected in Fog computing …
Optimized Vgg16 For Multi-Class Classification Of Alzheimer's Disease, Amira M. Basuoni, Hussein Seleem, Amira S. Ashour
Optimized Vgg16 For Multi-Class Classification Of Alzheimer's Disease, Amira M. Basuoni, Hussein Seleem, Amira S. Ashour
Mansoura Engineering Journal
Alzheimer’s disease (AD) is a severe neurological disorder that leads to memory loss and other cognitive impairments, ultimately resulting in death. With the advancement of deep learning, several researchers implemented a deep learning (DL)-based classification system for diagnosing such disease. However, determining the proper setting of the parameters, like learning rate and the number of dense units in the classification model is essential to achieve the best performance. Although manual tuning and grid search methods may be used, they are often time-consuming and cannot achieve the optimal model’s design. Accordingly, this paper proposed an improved model of the Visual Geometry …
Adaptive Watermarking Scheme For Enhanced Image Authentication And Restoration, Merna E. Ibrahim, Mohamed G. Abdelfattah, Mohamed A. Mohamed
Adaptive Watermarking Scheme For Enhanced Image Authentication And Restoration, Merna E. Ibrahim, Mohamed G. Abdelfattah, Mohamed A. Mohamed
Mansoura Engineering Journal
Traditional fragile watermarking schemes often struggle to balance tamper detection accuracy, image quality, and processing speed. This paper presents a novel adaptive fragile watermarking scheme that leverages Canny-edge detection to dynamically adjust watermark embedding based on image features. The proposed approach classifies image regions into smooth and dense areas. Larger 4×4 blocks are employed in smooth regions, prioritizing visual quality and processing speed, while smaller 2×2 blocks are used in edge and dense regions to enhance tamper detection accuracy. This adaptive strategy effectively balances competing factors, resulting in superior recovered image quality compared to fixed-block schemes. Experimental results demonstrate the …
Lstm-Based Model For Intrusion Detection In Sdn-Iot Networks, Randa Srour Ali, Eman Abdelhalim, Hala B. Nafea, Ahmad Hassan
Lstm-Based Model For Intrusion Detection In Sdn-Iot Networks, Randa Srour Ali, Eman Abdelhalim, Hala B. Nafea, Ahmad Hassan
Mansoura Engineering Journal
Ensuring security in Software-Defined Networking (SDN)-enabled Internet of Things (IoT) environments is a critical challenge due to the increasing complexity of cyber threats. This study proposes an intrusion detection system based on Long Short-Term Memory (LSTM) networks to enhance security in SDN-IoT networks. The research methodology involves data preprocessing, feature selection, and model training using the SDN-IoT dataset. Data preprocessing includes handling missing values and applying various encoding (label, one-hot, frequency, binary) and normalization (minmax, log, robust, z-scaling) techniques to optimize feature representation. Feature selection, conducted using Random Forest and correlation matrix analysis, reduces the feature set from 33 to …
Development Of An Examination Hall Malpractice Detection System Using Pose Estimation And Machine Learning, Etinosa Noma-Osaghae, Udoumoh John David, Joshua Sokowonci Mommoh, Olusogo Julius Adetunji, Oyedeji Ayo Isaac
Development Of An Examination Hall Malpractice Detection System Using Pose Estimation And Machine Learning, Etinosa Noma-Osaghae, Udoumoh John David, Joshua Sokowonci Mommoh, Olusogo Julius Adetunji, Oyedeji Ayo Isaac
Mansoura Engineering Journal
Examination malpractice remains a critical concern, driving the need for robust and efficient detection systems to uphold academic integrity. This research introduces a novel approach to examination malpractice detection by leveraging pose estimation and machine learning to address key gaps in existing solutions. Current systems often rely exclusively on either pose estimation or object detection, failing to exploit the synergistic potential of combining these techniques. This study bridges this gap by integrating deep learning models with complementary capabilities to enhance detection accuracy, robustness, and coverage. The proposed methodology utilises OpenPose for precise human pose estimation, enabling the detection of body …
Subordinate Prosecutors’ Independence, Bruce A. Green, Jessica A. Roth
Subordinate Prosecutors’ Independence, Bruce A. Green, Jessica A. Roth
Articles
This essay is about subordinate prosecutors’ independence to do what they think constitutes “seeking justice” when they perceive that their boss, or their boss’s boss, wants them to do something that is unjust—not illegal, but unjust. Of course, if subordinate prosecutors want to do either what they are told to do or what they infer that a higher-up wants them to do, they can do so, as long as the conduct is legal. Subordinate prosecutors might choose to disregard their own professional judgment of what justice requires because they share their boss’s objectives, because they see conforming as a route …
Law, Conflict, And Hybrid Warfare: A Teaching Imperative For A Changing World, Cynthia Alkon, Andrea K. Schneider
Law, Conflict, And Hybrid Warfare: A Teaching Imperative For A Changing World, Cynthia Alkon, Andrea K. Schneider
Articles
Lawyers increasingly find themselves at the frontlines of the battlefield, just not in the traditional sense. Hybrid warfare is a conflict form that combines traditional military offensive measures with nontraditional methods, including the harnessing of legal systems to achieve strategic goals. Lawyers have always been at the frontline of typical legal risk assessment, thinking about a client's risk of liability or regulation costs generally. Now, lawyers must stand at the ready for a lot more: lawyers must be prepared for cyber-attacks, disinformation campaigns using artificial intelligence, the use of court systems to suppress reporting or shield bad actors, and so …
A Textbook Equity Student Advisory Board, Karlee Colby, Anne Marie H. Gruber
A Textbook Equity Student Advisory Board, Karlee Colby, Anne Marie H. Gruber
Faculty Publications
Engaging college students in advocacy related to open educational resources (OER) is an important way to raise awareness and encourage OER adoption on campuses in higher education. The student perspective is vital to encouraging instructors and administrators to be responsive to student needs, concerns, and preferences related to course materials access, and to consider affordability and usage rights. This case study describes the library-facilitated Textbook Equity Student Advisory Board at the University of Northern Iowa, a medium-sized regional comprehensive university. The board serves as a two-way communication outlet between textbook equity campus leaders and students, including student government. This article …
Coopting Disruption, Mark A. Lemley, Matthew Wansley
Coopting Disruption, Mark A. Lemley, Matthew Wansley
Articles
Our economy is dominated by five aging tech giants – Alphabet, Amazon, Apple, Meta, and Microsoft. In the last twenty years, no company has commercialized a new technology in a way that threatens them. Why?
We argue that the tech giants have learned how to coopt disruption. They identify potentially disruptive technologies, use their money to influence the startups developing them, strategically dole out access to the resources the startups need to grow, and seek regulation that makes it harder for the startups to compete. When a threat emerges, they buy it off. And after they acquire a startup, they …
Stronger Together Newsletter, January 2025, Office Of Inclusive Excellence
Stronger Together Newsletter, January 2025, Office Of Inclusive Excellence
News, Magazines and Reports
Rev. Dr. Martin Luther King Jr. Day Celebration, Inclusion in Bloom, Introducing The Academy for Inclusive Excellence Education & Development, Lunar New Year, Human Library, Inclusive Excellence Spotlight, Upcoming Events
Artificial Intelligence And Digital Technologies In Finance: A Comprehensive Review, Soudeh Pazouki, Mohamad Jamshidi, Mirarmia Jalali, Arya Tafreshi
Artificial Intelligence And Digital Technologies In Finance: A Comprehensive Review, Soudeh Pazouki, Mohamad Jamshidi, Mirarmia Jalali, Arya Tafreshi
Finance Faculty Publications
This study explores the transformative impact of artificial intelligence (AI) and digital technologies on the financial technology (FinTech) industry, highlighting their role in fostering business growth, operational efficiency, and enhanced customer engagement. AI-driven strategies have unlocked new avenues for streamlining workflows, boosting productivity, and expanding financial inclusion by reaching underrepresented populations. However, these advancements also pose challenges, including navigating complex regulatory frameworks and adapting to the rapidly evolving technological landscape. This paper delves into the macroeconomic effects of AI, examining its influence on labor markets, consumer behavior, and organizational success. Furthermore, the paper discusses blockchain applications and their potential to …
Does The Acquirer's Complexity Affect The Market Reaction To M&A Decisions?, Rajib Chowdhury, John A. Doukas
Does The Acquirer's Complexity Affect The Market Reaction To M&A Decisions?, Rajib Chowdhury, John A. Doukas
Finance Faculty Publications
We examine whether and how acquiring firms' complexity affects investor perception at the announcement of M&A decisions. Using well-established data of firm complexity developed through combining machine learning and a lexicon of words, we find a significant positive relationship between acquiring firm complexity and cumulative abnormal returns (CAR), indicating that more intricate firms are viewed as more valuable or competent in mergers and acquisitions. This association is stronger for acquirers with high operating risk, organizational capital, R&D intensity, large and independent boards, and larger targets. We also present evidence that high-complexity bidders offer higher takeover premiums. Our study contributes to …
Are Csr Incidents Truly Bad News?, Chen Chen, John A. Doukas, Rongyao Gloria Zhang
Are Csr Incidents Truly Bad News?, Chen Chen, John A. Doukas, Rongyao Gloria Zhang
Finance Faculty Publications
We revisit whether disclosures of negative Corporate Social Responsibility (CSR) incidents adversely affect firms' stock prices. While univariate tests reveal significant negative abnormal returns around incident announcements, the effect disappears once firm characteristics, industry, and time‐fixed effects are controlled for. We find no robust evidence that CSR incidents or firms' Environmental, Social, and Governance (ESG) commitments influence stock price reactions on the event day or across broader windows. These results suggest that previously documented negative market responses may be attributable to endogeneity. Our baseline results are consistent with informed trading behavior: short‐sellers do not increase activity in incident‐related stocks relative …
Guided Autonomy: A Research-Based Approach To Improving Students' Wellbeing And Decision-Making In The Development Of Problem-Solving Skills, Jonathan E. Moore
Guided Autonomy: A Research-Based Approach To Improving Students' Wellbeing And Decision-Making In The Development Of Problem-Solving Skills, Jonathan E. Moore
Akron Law Faculty Publications
Law schools and the legal profession face a wellbeing crisis. Law students and lawyers suffer from high rates of depression, substance abuse, and job dissatisfaction. Research shows that cultivating autonomy—the sense of control over one’s own decisions and actions—is key to wellbeing and success in legal education and practice. Yet, fostering autonomy in new law students is challenging, as too much independence too soon can overwhelm learners and increase stress. This article introduces a “guided autonomy” approach for law students, with a focus specifically on legal writing courses. The article combines insights from Self-Determination Theory and Cognitive Load Theory to …
Law On Digital Banking Risk Management - Experiences Of Several Countries And Challenges For Such Developing Countries As Vietnam, Sue M. Altmeyer, Cao Dinh Lanh, Phan Dang Hai
Law On Digital Banking Risk Management - Experiences Of Several Countries And Challenges For Such Developing Countries As Vietnam, Sue M. Altmeyer, Cao Dinh Lanh, Phan Dang Hai
Akron Law Faculty Publications
In the context of globalization and the continuous development of financial markets, the banking and financial services industry is increasingly complex, accompanied by potential legal risks that organizations need to deal with face-to-face. Risk management of banking operations in the digital environment is becoming increasingly important for financial institutions and banks, as it is essential to help protect organizations' assets, reputation, and stability. This article is based on analysis and research of the law in several countries to discern possible changes to the law on digital banking risk management in Vietnam. Three goals will be assessed: i) building a comprehensive …
A View Of The Restaurant Script Through The Lens Of Hierarchical Planning, Jamie C. Macbeth, Mark Roberts, Boming Zhang, Sharmin Badhan, Molly Neu, Tanush Garg, Yining Hua, Manushaqe Muco, Mackie Zhou
A View Of The Restaurant Script Through The Lens Of Hierarchical Planning, Jamie C. Macbeth, Mark Roberts, Boming Zhang, Sharmin Badhan, Molly Neu, Tanush Garg, Yining Hua, Manushaqe Muco, Mackie Zhou
Computer Science: Faculty Publications
The flexible nature of human cognition and of the structures it uses is well known, as is the difficulty of building cognitive systems that exhibit transfer and use the same structures for radically different tasks. In this paper, we perform a close examination of Schank-Abelsonian scripts, picking apart the goal- and plan- oriented nature of low-level acts and high-level reasoning inherent in them. We then view scripts through the lens of hierarchical planning systems and construct the well-known restaurant script as a hierarchical goal network planning domain. These are evidence in support of a claim that some, if not all, …
The Central Role For Troponin C Amino-Terminal ⍺-Helix In Vertebrate Thin Filiment Ca²⁺-Activation, Yun Shi, Lauren A. Blackwell, Ryan K. Schroy, B. Max Cleland, Cristina M. Risi, Michelle S. Parvatiyar, Jose R. Pinto, Vitold E. Galkin, P. Bryant Chase
The Central Role For Troponin C Amino-Terminal ⍺-Helix In Vertebrate Thin Filiment Ca²⁺-Activation, Yun Shi, Lauren A. Blackwell, Ryan K. Schroy, B. Max Cleland, Cristina M. Risi, Michelle S. Parvatiyar, Jose R. Pinto, Vitold E. Galkin, P. Bryant Chase
Department of Biomedical and Translational Sciences Faculty Publications
Troponin C (TnC) is the Ca²⁺-sensing subunit of troponin that is responsible for activating thin filaments in striated muscle, and, in turn, for regulating the systolic and diastolic contractile function of cardiac muscle. The secondary structure of vertebrate TnC is mainly composed of α-helices, with nine helices named sequentially, starting from the amino terminus, from N to A–H. The N-helix is a 12-residue-long α-helix located at the extreme amino terminus of the protein and is the only helical structure that does not participate in forming Ca²⁺-binding EF-hands. Evolutionarily, the N-helix is found only in TnC from mammalian species and most …
Implementing A Chatbot To Promote Hereditary Breast & Ovarian Cancer Genetic Screening In Women's Health: Identifying Barriers And Facilitators To Screening Adoption, Easton N. Wollney, Shireen Madani Sims, Luisel J. Ricks-Santi, Elizabeth Eddy, Daniel Wiesman, Carla L. Fisher
Implementing A Chatbot To Promote Hereditary Breast & Ovarian Cancer Genetic Screening In Women's Health: Identifying Barriers And Facilitators To Screening Adoption, Easton N. Wollney, Shireen Madani Sims, Luisel J. Ricks-Santi, Elizabeth Eddy, Daniel Wiesman, Carla L. Fisher
Department of Biomedical and Translational Sciences Faculty Publications
Background
To promote genetic screening among women at risk for hereditary breast and ovarian cancer (HBOC), the American College of Obstetricians and Gynecologists recommends that risk assessment be integrated into practice. Chatbots like the Genetic Information Assistant (Gia®) are increasingly implemented to expand access to hereditary genetic screening. Factors that impact chatbot implementation for HBOC risk screening and women's uptake are not fully realized. To refine implementation strategies prior to full scale implementation, we sought to identify women's perceived facilitators/barriers to adopting Gia screening in a rural population within a large healthcare system in the southern United States.
Methods
We …
Phenotype Specific Nuclear Lamina Remodeling In Hipsc Derived Cardiomyocytes Bearing Tnnt2 Sarcomeric Variants, Isabella Leite Coscarella, Olalekan H. Usman, Lili Wang, Maicon Landim-Vieira, Lillian Wirstiuk, Amber N. Brown, Diego A. R. Zorio, Brian K. Washburn, Cynthia Vied, Bjorn C. Knollmann, Christopher Solís, Vitold E. Galkin, P. Bryant Chase, J. Travis Hinson, Jerome Irianto, Jose Renato Pinto
Phenotype Specific Nuclear Lamina Remodeling In Hipsc Derived Cardiomyocytes Bearing Tnnt2 Sarcomeric Variants, Isabella Leite Coscarella, Olalekan H. Usman, Lili Wang, Maicon Landim-Vieira, Lillian Wirstiuk, Amber N. Brown, Diego A. R. Zorio, Brian K. Washburn, Cynthia Vied, Bjorn C. Knollmann, Christopher Solís, Vitold E. Galkin, P. Bryant Chase, J. Travis Hinson, Jerome Irianto, Jose Renato Pinto
Department of Biomedical and Translational Sciences Faculty Publications
[Summary] Cardiomyocytes endure physical stress from the myocardium environment while generating their own mechanical strains. The force generated by sarcomeres is transmitted both longitudinally to adjacent sarcomeres and laterally to the cytoskeleton via intermediate filaments. This mechanical stimulus impacts other organelles, including the nucleus, thus playing a vital role in sensing and signaling nuclear adaptations. However, there is limited understanding of how changes in cardiac contractility affect nuclear mechanics. Here, we sought to investigate the effects of hyper- and hypo-contractility in nuclei of human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) bearing TNNT2 pathogenic variants associated with hypertrophic (HCM) or dilated …