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On A First Name Bias: A Bibliometric Study Of Six Writing Studies Journals, Joe Torok Jan 2025

On A First Name Bias: A Bibliometric Study Of Six Writing Studies Journals, Joe Torok

Wayne State University Dissertations

On a First Name Bias: A Bibliometric Study of Six Writing Studies Journals analyzes citation, authorship, source use, and other bibliometric patterns across a small collection of peer-reviewed journals featuring research from the academic field of writing studies (also known as rhetoric and composition). The study is grounded in a small but established tradition of RAD (replicable, aggregable, data-supported) scholarship in the field and uses bibliometric methods inspired by similar, primarily historiographic research studies within the field of writing studies and by critical inquiry from scholars across disciplines who have used bibliometric analysis to interrogate troubling patterns of publishing and …


Advancing Road Safety Through Software-Defined Vehicles, Raef Abdallah Jan 2025

Advancing Road Safety Through Software-Defined Vehicles, Raef Abdallah

Wayne State University Dissertations

Road traffic accidents are a significant global concern, claiming approximately 1.3 million lives annually and causing non-fatal injuries to 20–50 million people, many of which result in long-term disabilities. They are the leading cause of death for individuals aged 5–29 and impose a substantial economic burden, costing most countries 3% of their Gross Domestic Product (GDP). In addition to car accidents, other types of road incidents, such as collisions involving tall vehicles and overpasses, also pose significant risks. These accidents result in numerous fatalities and cause millions of dollars in damages annually. Environmental conditions like wet or icy roads and …


African Restorative Justice Philosophy: Practicing The Ubuntu Paradigm In The Composition Classroom, Francis Hamza Issah Jan 2025

African Restorative Justice Philosophy: Practicing The Ubuntu Paradigm In The Composition Classroom, Francis Hamza Issah

Wayne State University Dissertations

As the field of rhetoric and composition studies grapples with problematic institutional paradigms militating against its growth, changes taking place in the field mean that opportunity is created for a more equitable, inclusive, and diversified composition classroom. Questions of diversity, equity and inclusion have led me to investigate the composition classroom to identify and decenter structural systems of white mainstream literacy and language practices as a way of encouraging and building on the prior literacy practices of not just minority students, but all categories of students. In my dissertation research, I propose the practice of ubuntu as a way of …


The Alternative Schoolteachers Perspectives Of African American Males' Experiences In Alternative Education, Carlita Yevonne Y. Earl Jan 2025

The Alternative Schoolteachers Perspectives Of African American Males' Experiences In Alternative Education, Carlita Yevonne Y. Earl

Wayne State University Dissertations

ABSTRACT

This qualitative study explores how alternative educators perceive the experiences of African American male students in Disciplinary Alternative Education Programs (DAEPs). Guided by critical epistemology and grounded in Critical Race Theory, the research uses narrative inquiry to examine the ways in which disciplinary reassignment from traditional school settings affects Black male students. The study highlights the systemic issues that disproportionately affect African American males while addressing the larger context of educational inequality and its relationship to the school-to-prison pipeline. The results show that alternative teachers are aware of the critical need for equity-focused professional development, culturally sensitive practices, and …


Designing For Neurodiversity In Web Spaces, Kelly Getz, Kimberly Shotick Jan 2025

Designing For Neurodiversity In Web Spaces, Kelly Getz, Kimberly Shotick

Faculty Books & Book Chapters

In this chapter, we share how we carried out library website usability studies with neurodivergent students. The research is situated within the Social Model of Disability and places value on students' experiences challenges. Through usability studies and inclusive web service redesign plans, we center the opinions and expectations of neurodivergent student users in ways neurotypical users have been centered and designed around in the past. The chapter will share methods and best practices for conducting usability studies with neurodivergent individuals as well as findings from our own study.


Worlds Built And Borrowed: A Paracosmic Exploration Of The Metatextual Unconscious, Ryleigh Michele Roberts Jan 2025

Worlds Built And Borrowed: A Paracosmic Exploration Of The Metatextual Unconscious, Ryleigh Michele Roberts

Master’s Theses

This thesis explores literary phenomenology through the lens of fictional world-building and borrowing, integrating psychoanalytic play theories and reader response criticism, primarily through the works of D.W. Winnicott, Stanley Fish, and Wolfgang Iser. In applying this theoretical approach, the thesis investigates how fictional worlds function as intermediary phenomena through which creators can externalize and process their individual or collective experiences of being. Employing a comprehensive literary survey framework, the project spans a diverse range of texts, from canonical literature, such as the Brontës’ juvenilia and Orwell’s Nineteen Eighty-Four, to contemporary works like Stephenie Meyer’s Twilight and E.L. James’ Fifty Shades …


Thermo-Mechanical Behaviour Of Preloaded Low Cement Concrete Under Heating And Cooling Phase Of Fire Exposure, Mahadev Sitaram Rokade, James Lui, Yu Sheng, Tim Stratford, David Rush, Benny Suryanto Jan 2025

Thermo-Mechanical Behaviour Of Preloaded Low Cement Concrete Under Heating And Cooling Phase Of Fire Exposure, Mahadev Sitaram Rokade, James Lui, Yu Sheng, Tim Stratford, David Rush, Benny Suryanto

International Conference on Durability of Concrete Structures

Understanding the structural performance of concrete under fire, particularly during the cooling phase, is critical to ensuring post-fire safety. Concrete columns, as primary load-bearing elements, are especially vulnerable under such conditions. While Ordinary Portland Cement (OPC) concrete has been widely studied in fire, limited research has addressed the behaviour of sustainable alternatives such as Ground Granulated Blast Furnace Slag (GGBS) concrete, particularly under realistic thermal decay scenarios. GGBS, a by-product of steel production, offers a low-carbon alternative to OPC, reducing embodied CO₂ while enhancing long-term durability. This study investigates the fire response of 100 mm × 200 mm cylindrical specimens …


Ripples Of Change: Middle School Students Navigating The Future Of Our Watershed Through Eco-Stem, Elizabeth Andrew Thiel Jan 2025

Ripples Of Change: Middle School Students Navigating The Future Of Our Watershed Through Eco-Stem, Elizabeth Andrew Thiel

Indiana STEM Education Conference

Ripples of Change is an eco-STEM unit designed to address Indiana’s environmental education goals by fostering environmental literacy and informed decision-making among middle school students. By engaging students in community-based learning activities that empower students to address watershed issues, this eco-STEM unit promotes culturally sustaining integrated STEM education. Preliminary findings indicate increased student awareness and responsibility for their impact on local ecosystems using evidence-based reasoning, highlighting the potential for Ripples of Change to inspire global citizenship in students and scalable eco-STEM approaches.


Innovative Stem Learning Through Solar Oven Design: Promoting Creativity And Teamwork In Stem Education, Humphrey Chinenye Ochulor, Abigail Erskine, Comfort Temitope Aje Jan 2025

Innovative Stem Learning Through Solar Oven Design: Promoting Creativity And Teamwork In Stem Education, Humphrey Chinenye Ochulor, Abigail Erskine, Comfort Temitope Aje

Indiana STEM Education Conference

STEM education benefits significantly from integrating design-based learning (DBL) which fosters student creativity and teamwork. This research brief examines how solar oven design projects for K-12 students that involve DBL promote students' creative skills and teamwork. A literature review was done to investigate how solar oven design activities impacted student learning. Research has shown that students improve creativity and teamwork when these activities are carried out using DBL strategies.


Psychosocial Correlates Of Hiv Prevention, Care, And Well-Being Among Older Women Aging With Hiv, Thi Vu Jan 2025

Psychosocial Correlates Of Hiv Prevention, Care, And Well-Being Among Older Women Aging With Hiv, Thi Vu

Yale Graduate School of Arts and Sciences Dissertations

Background: Approximately 54% of the nearly 1.1 million people living with diagnosed HIV in the United States are aged 50 and older. From 2015 to 2019, diagnoses among women ages 55 years and older increased by 7% while diagnoses among other age groups decreased. In 2019, women made up 19% of all HIV diagnoses. Despite advances in HIV science and education, there is still a dearth of research focused on the growing population of older women with HIV. Durvasula’s Contextualized Model for HIV/AIDS Care and Prevention for Older Women highlights that older women with HIV face different barriers to care, …


Sports And Rhetorical Marginalization: A Case Study Of Angel Reese & Caitlin Clark, Diamond R. Williams Jan 2025

Sports And Rhetorical Marginalization: A Case Study Of Angel Reese & Caitlin Clark, Diamond R. Williams

Honors Undergraduate Theses

This thesis explores the manifestation of racism, sexism, and capitalism in the language and rhetoric of sports media through a case study of WNBA players Angel Reese and Caitlin Clark. This study theorizes that sports media has referred to Reese and Clark with damaging language tied to the intersections of their respective identities. This thesis also identifies and analyzes the presence of repeated themes throughout select sports media that mirror relevant theories surrounding stereotypes, biases, and marginalization in sports. Examining and analyzing the subtle nuances at play allows one to understand how language implicitly reinforces harmful narratives and, thus, how …


A Kinder Panopticon? Examining Effects Of Fairness And Justice On Performance Outcomes Under Advanced Electronic Monitoring Systems, William F. Tang Jan 2025

A Kinder Panopticon? Examining Effects Of Fairness And Justice On Performance Outcomes Under Advanced Electronic Monitoring Systems, William F. Tang

Honors Undergraduate Theses

The adoption of Electronic Performance Monitoring (EPM) systems has increased with the prevalence of remote workers post-COVID. Research indicates EPM yields conflicting performance and behavioral outcomes. EPM-related behavior can be predicted by organizational justice (the extent to which workplaces are perceived as fair in nature); environments with higher justice ratings are less likely to induce issues like stress and distrust. However, advanced EPM like electroencephalograms (EEG) may modulate the relationships between perceived fairness, stress, and work performance. This study assigned 42 participants to a modified vigilance test (based on Temple, et al., 2001), which participants took under 3 placebo monitoring …


Post-Incident Debriefings For Pediatric Intensive Care Nurse Burnout A Scoping Review, Sulah Emilie Monize Jan 2025

Post-Incident Debriefings For Pediatric Intensive Care Nurse Burnout A Scoping Review, Sulah Emilie Monize

Honors Undergraduate Theses

Burnout is prevalent among pediatric intensive care unit (PICU) nurses, impacting between 42-77% of them. High emotional burden, physical demand, and cognitive overload contribute to significant PICU nurse burnout prevalence. Burnout is linked to increased job turnover, compromised patient care, and decreased staff mental well-being. Addressing burnout is crucial to ensure patient safety and maintain care quality. Burnout in adult ICU nurses is well documented but less so with PICU nurses, and they face stressors unique to their setting, such as a vulnerable patient population and unique dynamics with families and providers. This scoping review includes 9 articles examining the …


Creating A Criteria Set To Evaluate The Use Of Cai Resources In K-6 Language Arts Education, Matthew T. Bates Jan 2025

Creating A Criteria Set To Evaluate The Use Of Cai Resources In K-6 Language Arts Education, Matthew T. Bates

Honors Undergraduate Theses

The purpose of this creative project was to research adequate educational practices regarding implementing technology and specifically CAI (Computer-Assisted Instruction) technology in the context of elementary education. This information was compiled into distinct categories based on research articles and policy statements. Then, the implications of each category were explored within the classroom. From this review of research, I created a criteria set for elementary educators to follow to evaluate CAI in the framework of their own educational methods and classroom. This thesis presents an address on the issue of student engagement in elementary literacy classrooms by assisting students in actively …


Beyond The Bench: Historical Injustices And Future Pathways For Florida’S Family Court, David J. Blum Jan 2025

Beyond The Bench: Historical Injustices And Future Pathways For Florida’S Family Court, David J. Blum

Honors Undergraduate Theses

This thesis examines systemic inequities in Florida’s family law system, focusing on how legal doctrines, discretionary practices, and enforcement patterns disadvantage unwed and noncustodial fathers. Drawing on statutory analysis, case law, empirical studies, and psychological research, it evaluates several reforms designed to promote fairness while protecting child welfare. These include mandatory paternity testing at birth, a rebuttable presumption of equal custody, stronger enforcement of visitation orders, equitable tax restructuring, and improved training for legal professionals. Current Voluntary Acknowledgment of Paternity (VAP) procedures often create binding obligations without confirming biological parentage, resulting in long-term emotional, legal, and financial consequences. Research shows …


Ad Astra Per Aspera: Legal Revision Of Space Laws And Intellectual Property To Cultivate Global Alliance And Innovation, Jaiden E. Haggiag Jan 2025

Ad Astra Per Aspera: Legal Revision Of Space Laws And Intellectual Property To Cultivate Global Alliance And Innovation, Jaiden E. Haggiag

Honors Undergraduate Theses

This thesis explores the inadequate nature of the current legal space regime and points out the gaps in outer space laws, including the following: Jurisdictional Challenges, Frameworks of Liability, and IP (Intellectual Property) Enforcement, utilizing laws such as the Outer Space Treaty (OST), the Liability Convention, the Registration Convention, the Moon Agreement, the Patent Cooperation Treaty (PCT), and TRIPS, along with national laws like the U.S. Commercial Space Launch Competitiveness Act and The Inventions in Outer Space Act (35 U.S.C. § 105.). Through analysis of current scholarly proposals and treaty evolution and synthesize to provide policy options, the goal of …


An Analysis Of The Constitutionality Of Florida's 2024 Hb 3: “Online Protections For Minors,” Comparative To Other State Regulations Of The Internet, Evan J. Siegel Jan 2025

An Analysis Of The Constitutionality Of Florida's 2024 Hb 3: “Online Protections For Minors,” Comparative To Other State Regulations Of The Internet, Evan J. Siegel

Honors Undergraduate Theses

This thesis examines the constitutionality of the Florida House of Representatives’ 2024 priority bill, HB 3: “Online Protections for Minors,” through its ongoing litigation in North Florida. The broad nature of the bill, which is now Florida law, and its burden on accessing constitutionality protected speech and/or expression may not be consistent with the First and Fourteenth Amendments to the United States Constitution. How the law defines and shapes what material may be accessible to people on the Internet, or the means they would need to use to create a social media account, are questions many other courts have begun …


Parents’ Perspectives On Emotional Regulation In Their Children With Autism Spectrum Disorder, Diana Stewart Jan 2025

Parents’ Perspectives On Emotional Regulation In Their Children With Autism Spectrum Disorder, Diana Stewart

Honors Undergraduate Theses

The current study’s main research question was whether emotional dysregulation of children with Autism Spectrum Disorder (ASD) affects parental stress levels. This project examined various negative emotional reactions, such as anger, sadness, worry, anxiety, and tantrums that were present in children with an ASD diagnosis, ages 4 to 13. The research consisted of five psychological assessments with strong psychometric properties. The whole survey was supposed to be filled out by a parent or a caregiver of a child, since children are considered a vulnerable population when it comes to research. The first assessment was the Childhood Autism Spectrum Test (CAST) …


0th Order Solutions Of The Wavefunctions For The Quantum Elliptical Box And Microstrip Antenna, Nishtha Tikalal Jan 2025

0th Order Solutions Of The Wavefunctions For The Quantum Elliptical Box And Microstrip Antenna, Nishtha Tikalal

Honors Undergraduate Theses

For a quantum particle confined to a two-dimensional elliptical box or electromagnetic wave in a microstrip antenna, geometrical and boundary condition interplay result in a spectrum of spatial patterns. Due to the asymmetrical nature of the ellipse, we are faced with continuous symmetry reductions, leaving both degenerate and nondegenerate solutions. Here, we present a complete derivation of an analytical solution and visualizations of the fundamental wavefunctions for both Dirichlet and Neumann boundary conditions respectively corresponding to the quantum elliptical box and the elliptical microstrip antenna.

We demonstrate that the eigenmodes, governed by eccentricity, directly correspond to the modal field distributions …


The Post-Alert Lexicon: A Multiphased Study To Develop Content For Post-Alert Messages, Jeannette Sutton, Hugh D. Walpole, Micki Olson, Lauren B. Cain, Savanah Olivas, Bruce Pollock, Nicholas Waugh Jan 2025

The Post-Alert Lexicon: A Multiphased Study To Develop Content For Post-Alert Messages, Jeannette Sutton, Hugh D. Walpole, Micki Olson, Lauren B. Cain, Savanah Olivas, Bruce Pollock, Nicholas Waugh

Emergency Preparedness, Homeland Security, and Cybersecurity Faculty Scholarship

Using a multi-phased, mixed methods approach, grounded in theory on alerts and warnings, the Post-Alert Lexicon serves as a companion to the Warning Lexicon to provide evidence-based guidance on how to construct a post-alert message for 45 hazards and missing person events. We draw from the results of quantitative content analyses of a census of post-alert messages issued as Wireless Emergency Alerts from 2012-2022, and public message testing experiments for three hazard types (wildfire, earthquake, and bomb threat), to find that a focus on hazard resolution and public action, rather than the commonly employed language of “all clear,” increases message …


A Unifying Double-Reference Approach To Semantic Paradoxes: From The White-Horse-Not-Horse Paradox And The Ultimate-Unspeakable Paradox To The Liar Paradox In View Of The Principle Of Noncontradiction, Bo Mou Jan 2025

A Unifying Double-Reference Approach To Semantic Paradoxes: From The White-Horse-Not-Horse Paradox And The Ultimate-Unspeakable Paradox To The Liar Paradox In View Of The Principle Of Noncontradiction, Bo Mou

Faculty Research, Scholarly, and Creative Activity

The purpose of this study is to suggest and explain an engaging approach to three distinct types of (alleged or genuine) semantic paradoxes, the White-Horse-Not-Horse Paradox, the Ultimate-Unspeakable Paradox, and the Liar Paradox, in a unifying way that is sensitive to distinct features of them. Although the three types of semantic paradoxes address distinct types of objects, and although their seemingly paradoxical features are different (alleged or genuine), their distinct structures and contents can be understood and treated on the same common ground, which is jointly conceived in people's pretheoretic understandings of truth and of the double-reference feature of people's …


Supports For Mental Well-Being Valued By Healthcare Workers: Qualitative Analysis Of Data From A Canadian Cohort Of Healthcare Workers During The Covid-19 Pandemic, Shannon Marie Ruzycki, Anil Adisesh, Quentin Durand-Moreau, France Labrèche, Tanis Zadunayski, Erica Stroud, Nicola Cherry Jan 2025

Supports For Mental Well-Being Valued By Healthcare Workers: Qualitative Analysis Of Data From A Canadian Cohort Of Healthcare Workers During The Covid-19 Pandemic, Shannon Marie Ruzycki, Anil Adisesh, Quentin Durand-Moreau, France Labrèche, Tanis Zadunayski, Erica Stroud, Nicola Cherry

Études primaires

A prospective cohort of 4964 HCWs from four Canadian provinces was established early in the COVID-19 pandemic. Participants were invited to comment about workplace mental health supports at three time points. We performed a thematic content analysis of responses from 1738 participants using the Social Support Behaviour Code framework to categorize barriers to support as informational, tangible, emotional, social, or expressing esteem. Themes were synthesized into suggestions for healthcare organizations to prepare for future crises. Formal and informal peer support, workplace mental health supports, and one-on-one counseling were most often mentioned as valued. Analysis suggested that workplace social networks as …


Expériences Vécues Et Perceptions De Personnes Étudiantes Internationales Sur Les Mesures Et Les Services Offerts Par Les Universités Québécoises Pendant La Pandémie De Covid-19 = Experiences And Perceptions Of International Students Regarding Measures And Services Offered By Quebec Universities During The Covid-19 Pandemic, Farrah Bérubé, Jessica Dubé, Jorge Frozzini, Daniel Côté Jan 2025

Expériences Vécues Et Perceptions De Personnes Étudiantes Internationales Sur Les Mesures Et Les Services Offerts Par Les Universités Québécoises Pendant La Pandémie De Covid-19 = Experiences And Perceptions Of International Students Regarding Measures And Services Offered By Quebec Universities During The Covid-19 Pandemic, Farrah Bérubé, Jessica Dubé, Jorge Frozzini, Daniel Côté

Études primaires

Cet article fait état d’une partie des résultats d’une recherche menée auprès de personnes étudiantes internationales (PÉI) qui fréquentaient des universités québécoises pendant la pandémie de COVID-19. La recherche portait sur les usages sociaux des technologies de l’information et de la communication (TIC) et sur la qualité de vie des PÉI en période de confinement. Les résultats présentés et discutés dans cet article se rapportent plus spécifiquement aux expériences et perceptions des PÉI sur les mesures et les services offerts par les universités en contexte de confinement. Afin de répondre à cet objectif, des entretiens semi-dirigés, menés auprès de 40 …


Vocational Training And Occupational Health: An Ergonomics Approach To Gender And Disabilities For Social Sustainability, Myriam Bérubé, Céline Chatigny, Marie Laberge Jan 2025

Vocational Training And Occupational Health: An Ergonomics Approach To Gender And Disabilities For Social Sustainability, Myriam Bérubé, Céline Chatigny, Marie Laberge

Études primaires

The Work-Oriented Training Path (WOTP) in Quebec, Canada, is a dual vocational training program that offers students with learning difficulties supervised traineeships. Teachers play a pivotal role in managing students' occupational health and safety (OHS), yet must do so under tight time constraints, limited institutional guidance and highly diverse student profiles. Building on an activity-centered ergonomics and capabilities framework, this multiple-case study explores how gender, disabilities, and work determinants shape OHS management within the WOTP, emphasizing their implications for social sustainability. Twenty-seven semi-structured interviews were conducted with 15 WOTP teachers; 497 narrated anecdotes, which are units of speech when teachers' …


Organizational And Structural Factors In Building The Therapeutic Alliance In A Work Rehabilitation Program With Injured Immigrant Workers In Quebec, Daniel Côté, Maude Arsenault, Jessica Dubé Jan 2025

Organizational And Structural Factors In Building The Therapeutic Alliance In A Work Rehabilitation Program With Injured Immigrant Workers In Quebec, Daniel Côté, Maude Arsenault, Jessica Dubé

Études primaires

Abstract

The therapeutic alliance is central to occupational rehabilitation, particularly for immigrant workers who face unique challenges of migration and of social and occupational integration. This study explores the development and maintenance of this alliance between immigrant workers with compensated work injuries and their care providers during work rehabilitation. Using ethnography, semi-structured interviews, and focus groups, the qualitative case study involved 7 injured immigrant workers and their interdisciplinary clinical team. The study identified several factors that weakened the alliance, including administrative complexity, conflicting views on pain and disability, cultural stereotypes, and interorganizational communication issues. Many of these challenges were systemic …


Evolution Of Stressors For Healthcare Workers Over The Covid-19 Pandemic, F. Labrèche, Q. Durand-Moreau, A. Adisesh, J.-M. Galarneau, Shannon Ruzycki, Tanis Zadunayski, Nicola Cherry Jan 2025

Evolution Of Stressors For Healthcare Workers Over The Covid-19 Pandemic, F. Labrèche, Q. Durand-Moreau, A. Adisesh, J.-M. Galarneau, Shannon Ruzycki, Tanis Zadunayski, Nicola Cherry

Études primaires

Background:

Many studies have documented exposure to psychosocial factors in healthcare workers (HCWs) during the COVID-19 pandemic. Few have done it prospectively with open-ended questions.

Aims:

To describe the evolution of stress factors reported by HCWs during the pandemic.

Methods:

A prospective cohort of 4964 HCWs (physicians, nurses, healthcare aides, personal support workers), from four Canadian provinces, received four online questionnaires between the springs 2020 and 2022. Responses to an open-ended question on stressful events were coded into 25 stressors. Multilevel logistic regressions assessed trends in stressors, and the effect of gender, occupation, and age.

Results:

In 2020, 91% of …


Protein Marker-Dependent Drug Discovery Targeting Breast Cancer Stem Cells, Ashley V. Huang, Yali Kong, Kan Wang, Milton L. Brown, David Mu Jan 2025

Protein Marker-Dependent Drug Discovery Targeting Breast Cancer Stem Cells, Ashley V. Huang, Yali Kong, Kan Wang, Milton L. Brown, David Mu

Department of Biomedical and Translational Sciences Faculty Publications

Breast cancer is one of the most common cancers globally. Unfortunately, many patients with breast cancer develop resistance to chemotherapy and tumor recurrence, which is primarily driven by breast cancer stem cells (BCSCs). BCSCs behave like stem cells and can self-renew and differentiate into mature tumor cells, enabling the cancer to regrow and metastasize. Key markers like CD44 and aldehyde dehydrogenase-1 (ALDH1), along with pathways like Wingless-related integration site (Wnt), Notch, and Hedgehog, are critical to regulating this stem-like behavior of BCSCs and, thus, are being investigated as targets for various new therapies. This review summarizes marker-dependent strategies for targeting …


Antibiotic Resistance: The Growing Threats And Potential Solutions, Olisaemeka Zikora Akunne, Blessing Nkechi Emmanuel, Umar Faruk Saidu, Ayobami Sunday Akinnawo, Nasiru Ademola Adeyemi, Livia Chinaza Egoh, Malami Aishatu Muhammad, Olusegun Ayo Ade-Adekunle, Deborah Ahuoyiza Peter, Anne Amina Freitas Jan 2025

Antibiotic Resistance: The Growing Threats And Potential Solutions, Olisaemeka Zikora Akunne, Blessing Nkechi Emmanuel, Umar Faruk Saidu, Ayobami Sunday Akinnawo, Nasiru Ademola Adeyemi, Livia Chinaza Egoh, Malami Aishatu Muhammad, Olusegun Ayo Ade-Adekunle, Deborah Ahuoyiza Peter, Anne Amina Freitas

Department of Biomedical and Translational Sciences Faculty Publications

Antibiotic resistance (AR) has become a critical global health crisis, threatening the efficacy of antibiotics and increasing healthcare costs, morbidity, and mortality. The One Health approach, which emphasizes the interconnectedness of human, animal, and environmental health, is increasingly recognized as an essential framework for addressing the complex drivers of AR. This review explores the mechanisms of resistance, such as genetic mutations, horizontal gene transfer, and biofilm formation, along with contributing factors such as the overuse of antibiotics in healthcare and agriculture. We assess both traditional and emerging strategies to combat AR, including antimicrobial stewardship, the development of new antibiotics, and …


Identifying Notch-Regulated Genes Using A Specific Notch Signaling Inhibitor, Hammed Gafar Jan 2025

Identifying Notch-Regulated Genes Using A Specific Notch Signaling Inhibitor, Hammed Gafar

EWU Masters Thesis Collection

Bone remodeling is a dynamic process that requires a balance between bone resorption by osteoclasts and bone formation by osteoblasts to maintain skeletal integrity. Disruptions to this equilibrium can lead to pathological conditions such as osteoporosis. Osteoclasts originate from macrophages, and their differentiation is regulated by several signaling pathways, notably the notch signaling pathway. Gamma-secretase, an enzyme crucial for initiating notch signaling, can be inhibited by DAPT. However, DAPT also targets non-Notch substrates, complicating the identification of genes specifically regulated by Notch. To address this limitation, this study employed IMR-1A, a selective Notch pathway inhibitor that disrupts the assembly of …


Parallel Inquiries: Investigation Of Social Resource Use In Early Career Stem Teachers And Impacts Of Metal Pollution On Fingernail Clam Microbiome, Emily Hamada Jan 2025

Parallel Inquiries: Investigation Of Social Resource Use In Early Career Stem Teachers And Impacts Of Metal Pollution On Fingernail Clam Microbiome, Emily Hamada

EWU Masters Thesis Collection

No abstract provided.