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Articles 70291 - 70320 of 1519737
Full-Text Articles in Entire DC Network
Lived Experiences Of Older Adults After Involuntary Work Separation, Mark Mallock Rose
Lived Experiences Of Older Adults After Involuntary Work Separation, Mark Mallock Rose
Doctoral Dissertations and Projects
The purpose of this qualitative phenomenological study was to describe the lived experiences of those subjected to involuntary work separation at age 50+ in the United States. The literature concerning involuntary job loss is lacking in research pertaining to the 50+ age demographic. This research is important in the aspect that older workers face specific challenges that their younger counterparts may not after involuntary work separation. Understanding the psychological responses, positive aspects, and negative aspects of involuntary job separation in older adults added to the literature for those aged 50+. The research design was qualitative inquiry using virtual recorded interviewing …
Virtual Reality In Trauma Therapy: Clinicians Treating Posttraumatic Stress Disorder (Ptsd) With Technological Resources In Minneapolis, Minnesota, Thomas E. Covington
Virtual Reality In Trauma Therapy: Clinicians Treating Posttraumatic Stress Disorder (Ptsd) With Technological Resources In Minneapolis, Minnesota, Thomas E. Covington
Doctoral Dissertations and Projects
This dissertation aims to establish how virtual reality (VR) integrated with other technological devices in the management of posttraumatic stress disorder (PTSD). The technology will lay the foundation for how it can establish controlled and safe VR contexts that can help patients address traumatizing occurrences. I will also stress the use of virtual therapists through online tools and applications, giving access to those who cannot attend meetings in person. Also, I will examine the individualization of the treatment process through the application of digital technologies and their potential effects on the outcomes of the therapeutic process. The research also examines …
Understanding The Lived Experiences Of Post-Graduates Of A Spiritual Direction Training Program Rooted In Ignatian Spirituality: A Phenomenological Study, Traci Arends
Doctoral Dissertations and Projects
The purpose of this hermeneutic phenomenological study was to understand and explain the lived experiences of the graduates of the Spiritual Direction Training Program at the Ignatian Ways Center for Spirituality (IWCS). The theory guiding this study was Mezirow’s theory on transformative learning as it informs the transformative journey for the graduates. With this in mind, the central research question was, “What are the transformative learning experiences of graduates of the Spiritual Direction Training Program at the IWCS?” This qualitative design was appropriate because it considered the nature of the problem. The study utilized purposeful sampling of the lived experience …
Do Parents ‘Know Best’ When It Comes To Their Teenaged Children’S Experiences Of Sexual Content Online?, Harrison W. See, Kjartan Ólafsson, Brian O’Neill, Lelia Green, Carmen Jacques, Kelly Jaunzems
Do Parents ‘Know Best’ When It Comes To Their Teenaged Children’S Experiences Of Sexual Content Online?, Harrison W. See, Kjartan Ólafsson, Brian O’Neill, Lelia Green, Carmen Jacques, Kelly Jaunzems
Research outputs 2022 to 2026
In 2010, the EU Kids Online project, and aligned AU Kids Online study, interviewed one parent and one child (9–16) from 25,542 families across 26 countries. Information gathered included parents’ awareness of their child’s experiences of sexual content online. This dataset has since been updated by recent ethnographic work in Australia and Ireland, capturing parents’ approaches to managing their children’s (11–17) digital engagement with sexual content. Parents identified risks and benefits in their children’s encounters with adult content online. This article concludes that parents do not judge the efficacy of their digital parenting around preventing their child from seeing restricted …
Phase 1, First-In-Human, Single-/Multiple-Ascending Dose Study Of Iluzanebart In Healthy Volunteers, Andreas Meier, Spyros Papapetropoulos, Andrew Marsh, Kelly Neelon, David Stiles, Ryan O'Mara, Evan A Thackaberry, Marco Colonna, Raj Rajagovindan
Phase 1, First-In-Human, Single-/Multiple-Ascending Dose Study Of Iluzanebart In Healthy Volunteers, Andreas Meier, Spyros Papapetropoulos, Andrew Marsh, Kelly Neelon, David Stiles, Ryan O'Mara, Evan A Thackaberry, Marco Colonna, Raj Rajagovindan
2020-Current year OA Pubs
OBJECTIVE: To evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of iluzanebart, a fully human monoclonal antibody TREM2 (triggering receptor expressed on myeloid cells 2) agonist, after single- (SAD) and multiple-ascending-dose (MAD) administration.
METHODS: Healthy adult volunteers (N = 136) received intravenous placebo or iluzanebart 1-60 mg/kg (SAD) or 10-60 mg/kg (MAD) followed by serial pharmacokinetics and safety assessments. Safety assessments included adverse events (AEs), vital signs, electrocardiograms, and clinical laboratory evaluations. Pharmacokinetics were assessed through noncompartmental analysis. The study also included open-label cohorts (3, 10, 20, 40, 60 mg/kg SAD; 10, 20, 40 mg/kg MAD) for cerebrospinal fluid (CSF) collection …
C-Band Air To Ground Communication System For Uav, Mubark Alghamdi
C-Band Air To Ground Communication System For Uav, Mubark Alghamdi
Theses and Dissertations
C band spectrum 5030-5091 MHz is allocated for command-and-control communication services with unmanned aircraft systems. This document evaluates the possibility of using 3GPP 5G standards for provisioning of such services. Channelization of the spectrum and major system parameters are proposed. The performance of the proposed system in channel fading environment is evaluated using MATLAB based simulations. The evaluations examine SINR, and average throughput of the proposed system at different altitudes of the unmanned aircraft system. MATLAB simulations are used to evaluate system performance in free-space environments. Signal-to-Interference-plus-Noise Ratio (SINR) and Reference Signal Received Power (RSRP) are predicted at different UAS …
Characterizing Human Mobility Patterns In Saudi Arabia Using Cellular Data, Meshal Alnefaie
Characterizing Human Mobility Patterns In Saudi Arabia Using Cellular Data, Meshal Alnefaie
Theses and Dissertations
The study analyzes human mobility in Saudi Arabia. Using crowd-source data, Riyadh mobility is analyzed to find trends and highlight mobility patterns of individuals in Riyadh. Then, the mobility of Riyadh is compared with that of Jeddah and Dammam in a similar data collection and analysis. Four mobility metrics are utilized: Number of Visited Locations (NLOC), Number of Unique Locations (NULOC), Radius of Gyration (RGYR), and Distance Traveled (DTRV). The results show interesting outcomes about individuals in the three cities. Although these cities are far from each other, they observe the same mobility patterns. These findings have the potential to …
Developing End-To-End Imitation Learning For Asteroid Proximity Operations, Patrick David Quinn
Developing End-To-End Imitation Learning For Asteroid Proximity Operations, Patrick David Quinn
Theses and Dissertations
Asteroid exploration remains a popular topic in the scientific community, however hurdles still exist for controlling spacecraft within the asteroid environment. Communication delays often require the usage of limited onboard computing hardware for navigation. Additionally, long mission timelines must be accommodated with highly efficient fuel use. Considering these issues, it is apparent that any guidance, navigation, and control (GNC) system in these spacecraft should emphasize both computational and fuel efficiency in its design. Furthermore, the integration of a robust state estimation system is necessary for the successful deployment of such systems. The development of a controller aiming to address these …
The Marionette Among Us: The Dark Triad, Influence Tactics, And The Fabric Of Team Relationships, Jarret Nathan Bain
The Marionette Among Us: The Dark Triad, Influence Tactics, And The Fabric Of Team Relationships, Jarret Nathan Bain
Theses and Dissertations
This study examines the influence of the Dark Triad personality traits—Machiavellianism, Narcissism, and Psychopathy—on workplace team dynamics, particularly through the use of hard and soft interpersonal influence tactics. The research focuses on Team Member Exchange (TMX) as a measure of perceived relationship quality among team members. Using a cross-sectional survey of employed adults recruited through Amazon Mechanical Turk (MTurk), the study investigated the relationships between Dark Triad traits, influence tactics, and TMX. The findings reveal that while Narcissism is positively correlated with TMX, Machiavellianism and Psychopathy show more complex patterns of association, impacted by the choice of influence tactics. The …
Patterns Of Fire History And Vegetation Changes In The Last 5000 Years: A Paleoecological Study Of Iquitos, Annabel Zwarts
Patterns Of Fire History And Vegetation Changes In The Last 5000 Years: A Paleoecological Study Of Iquitos, Annabel Zwarts
Theses and Dissertations
The vegetation of the Amazonian rainforest is hypothesized to have been shaped by pre-Columbian activities, such as burning and palm management to various extents. Management of palms is hypothesized to have caused some of the most useful species to become hyperdominant in Amazonia. This study investigated the extent to which human activities over the past 5000 years affected palm abundances in mature lowland rainforests near Iquitos, Peru. I used phytoliths and charcoal from soil cores to determine the history of local floras, and modern palm surveys to compare modern phytolith occurrence with modern vegetation. Because pre-Columbian activity clustered along the …
An Analysis Of The Effects Of Embedded Instruction And Item Quality On Activity Selection, Julianne Isabella Fernandez
An Analysis Of The Effects Of Embedded Instruction And Item Quality On Activity Selection, Julianne Isabella Fernandez
Theses and Dissertations
Naturalistic teaching strategies, such as embedded instruction, have been used to effectively teach a variety of skills to individuals diagnosed with ASD and other developmental disabilities. However, the effect of embedding instructions on a child’s play preferences is unknown. The goal of this study is to evaluate whether response allocation is dependent on frequency of demands or quality of items available during preferred activities. We used a concurrent operants arrangement in which a room was divided into two sides and various toys were placed in each with embedded demands available in one side. In Experiment 1, researchers evaluated the time …
Use Of Pushed-In Pencel Pressuremeter Test For Shallow Foundation Design In Florida Fine Sands, Brhane Weldeanenya Ygzaw
Use Of Pushed-In Pencel Pressuremeter Test For Shallow Foundation Design In Florida Fine Sands, Brhane Weldeanenya Ygzaw
Theses and Dissertations
A comprehensive evaluation was conducted on the performance, consistency, and practical application of various in-situ geotechnical testing methods for predicting the settlement and bearing capacity of shallow foundations in Florida’s fine sands. The methods assessed include the Standard Penetration Test (SPT), Cone Penetration Test (CPT), Dilatometer Test (DMT), pushed-in PENCEL Pressuremeter Test (PPMT), and the pre-bored TEXAM Pressuremeter Test. A dual approach controlled indoor testing at the FDOT State Materials Office (SMO) and field investigations at three representative sites (Kingsley, Trenton, and the UCF research site), formed the experimental foundation.
Over thirty settlement prediction techniques and thirteen bearing capacity estimation …
Early Breast Cancer Detection With Ultrasound Data Using Nmf, Rutvi Khamar
Early Breast Cancer Detection With Ultrasound Data Using Nmf, Rutvi Khamar
Theses and Dissertations
Early detection of breast cancer significantly influences patient outcomes. Dynamic Contrast-Enhanced Ultrasound (DCE-US) has shown promise in early detection by visualizing tumor vascularity and perfusion dynamics in real-time. This study evaluates the efficacy of DCE-US in distinguishing four stages of cancer progression: normal, hyperplasia, ductal carcinoma in situ (DCIS), and invasive cancer, using a transgenic mouse model that mimics human breast cancer. Ultrasound burst pulses, while commonly used to remove unbound contrast agents, can potentially damage human tissues. Using the pre-pulse data helps mitigate this risk, ensuring safer and more reliable measurements. A VEGFR2-targeted microbubble contrast agent was injected, and …
Effects Of Reflective Journaling And Nudges On Academic Motivation And Engagement, Lakshmi Satya Sai Veda Mahita Uppuluri
Effects Of Reflective Journaling And Nudges On Academic Motivation And Engagement, Lakshmi Satya Sai Veda Mahita Uppuluri
Theses and Dissertations
This study investigates the effects of reflective journaling and motivational nudges on academic motivation and engagement among college students. Grounded in Self- Determination Theory (SDT), the research examines how different interventions influence intrinsic motivation, and academic behaviors such as class attendance, participation, and preparation. The study employed a between-group experimental design with three conditions: a control group, a journaling group, and a journaling group that also received daily motivational nudges. Results showed that students in the journaling groups—particularly those who received nudges—experienced a significant increase in academic motivation. While changes in academic engagement were not significant, the effect size suggested …
Stochastic Analysis With Operational Calculus In Reliability, Hend Hamdan Al-Jahani
Stochastic Analysis With Operational Calculus In Reliability, Hend Hamdan Al-Jahani
Theses and Dissertations
Our dissertation models several reliability systems subject to occasional random shocks of random magnitudes W1,W2,..occurring at times tau0, tau2,..In Model 1, the underlying system becomes inoperational if it wears out due to aging specified by a monotone increasing continuous function Delta identifying system's wear at any time t>=0 . The system is deemed inoperational if delta crosses a sustainability threshold at some moment T=(delta )^-1(D). The precise time T is difficult to identify making the realistic failure time randomly delayed and thus identified at some opportune observation epoch. The system can also fail due to damages by external shocks, …
The Effect Of Food Preference On The Efficacy Of The High-Probability Instructional Sequence To Treat Food Selectivity, Christina Marie Sheppard
The Effect Of Food Preference On The Efficacy Of The High-Probability Instructional Sequence To Treat Food Selectivity, Christina Marie Sheppard
Theses and Dissertations
Food selectivity involves avoiding certain foods based on type, texture, brand, smell, temperature, or presentation, and it affects 80% of children with intellectual and developmental disabilities. Although several antecedent-based and consequence-based behavioral interventions exist to increase acceptance and consumption of food in this population, one antecedent-based intervention that has shown promise both within and outside of a feeding context is the high-probability instructional sequence, which consists of the delivery of three high-probability instructions before delivery of a low-probability instruction. The high-probability sequence is used to increase compliance with instructions that have a low probability of completion (e.g., taking a bite …
The Impact Of Sibling Sexual Abuse On Parenting Stress, Giuliana Berry
The Impact Of Sibling Sexual Abuse On Parenting Stress, Giuliana Berry
Theses and Dissertations
Sibling sexual abuse is the most common yet least reported, treated, and studied manifestation of child sexual abuse (Bertele & Talmon, 2023; Caffaro & Conn-Caffaro, 2005; Krienert & Walsh, 2011; O’Brien, 1991). It is a particularly challenging form of intrafamilial sexual abuse for parents and caregivers because their children are both the victim and the perpetrator of the abuse. They struggle to balance the needs of both children (Duane et al., 2002; Tener et al., 2020) and may experience heightened stress and associated psychological difficulties. Parenting stress is linked to child and adolescent posttraumatic stress and internalizing and externalizing problem …
Evaluating A Video Modeling Approach To Teach Shelter Volunteers How To Interact With Dogs In The Shelter, Sean Michael Will
Evaluating A Video Modeling Approach To Teach Shelter Volunteers How To Interact With Dogs In The Shelter, Sean Michael Will
Theses and Dissertations
Well-trained volunteers are required to help meet the daily needs of dogs waiting to be adopted in animal shelters and to find new homes for them. Inadequate volunteer training leads to mismanagement and attrition of volunteers who are essential to helping shelter dogs get adopted. However, animal shelters often lack access to the resources and funds required to provide adequate training for volunteers. Using a nonconcurrent multiple baseline design, this study evaluated a cost-effective program consisting of video modeling with voiceover instruction, on-screen text, examples, and non-examples that instructed volunteers to interact with the dogs in a specific manner to …
Trends In And Factors Associated With Science Achievement Among Fourth Graders In Saudi Arabia: A Secondary Analysis Of Timss Data, Reda Massawe
Theses and Dissertations
This secondary analysis examined trends and factors associated with science achievement among fourth-grade students in Saudi Arabia using data from the Trends in International Mathematics and Science Study (TIMSS). Between 2007 and 2019, Saudi students consistently scored below the international average in science, with female students outperforming males by more than 30 points. The study addressed two issues: (1) reasons behind Saudi students’ underperformance and (2) limited research on contributing factors. TIMSS data from 2011, 2015, and 2019 were analyzed using descriptive, correlational, and regression methods. While trends across the years were explored, only 2019 data were used for detailed …
Exploration, Exploitation, And Financial Performance: The Long-Term Advantages Of Ambidextrous Companies, Georgi Aleksandrov Kirov
Exploration, Exploitation, And Financial Performance: The Long-Term Advantages Of Ambidextrous Companies, Georgi Aleksandrov Kirov
Theses and Dissertations
Researchers have advanced ambidexterity as an effective organizational strategy to cope with environmental and technological change. The use of divergent and incompatible core construct conceptualizations, overreliance on cross-sectional and perceptual performance measures, and persistent scarcity of longitudinal examinations have undermined empirical conclusions that ambidexterity works. This study seeks to ascertain whether ambidexterity enhances long-term financial performance under environmental conditions of munificence, dynamism, and external potential slack.
The study deploys a novel operationalization of the ambidexterity concept and develops company portfolios to compare the financial results of ambidextrous firms and their rivals. Based on a 25-year data set, the research finds …
Exploratory Study On Factors That Impact Job Embeddedness For Northeast Government And Commercial Aerospace Procurement Specialists, Nicholas Alaimo
Exploratory Study On Factors That Impact Job Embeddedness For Northeast Government And Commercial Aerospace Procurement Specialists, Nicholas Alaimo
Theses and Dissertations
This qualitative study examined job embeddedness theory and its impact on commercial and government aerospace procurement professionals in the Northeast United States. The research sought to understand the factors that influence why these professionals remain in their positions and what elements contribute to improved job performance. Job embeddedness theory explains employee retention through three key factors: perceived fit within their role, perceived links to organizational culture, and perceived sacrifices that would result from leaving.
The study identified six main themes. First, the research found both similarities and differences in how aerospace procurement specialists connect with aerospace culture in government subcontracting …
Matrix Training Of Verb Tenses With Autistic Children, Alexandra Lynn Ewald
Matrix Training Of Verb Tenses With Autistic Children, Alexandra Lynn Ewald
Theses and Dissertations
The purpose of this study was to extend the research on matrix training by evaluating its efficacy for producing recombinative generalization of regular verb tense endings. Three autistic children were shown videos of people known to the participants acting out behaviors associated with an action about to take place, currently taking place, or that took place. The targets (actors, actions, and verb tenses) were arranged in a matrix, and the targets appearing along the diagonal of the matrix were directly trained, while the remaining targets were probed to determine if the participant was able to emit correct responses without any …
Expressive And Interpretable User Engagement Prediction Using Multivariate Survival Processes, Akshay Aravamudan
Expressive And Interpretable User Engagement Prediction Using Multivariate Survival Processes, Akshay Aravamudan
Theses and Dissertations
The ability to characterize how information diffuses online is of paramount importance to stakeholders that are interested in tasks such as proposing solutions for mitigating and countering dis/misinformation, predicting user engagement of content in social media, planning marketing campaigns to roll-out products and planning dissemination of political campaign messaging among others. One such facet of learning the dynamics of information diffusion is the ability to predict user engagement or the popularity of a single piece of information as it spreads through an online medium. Existing works in this regard mainly either obfuscate user level information or utilize frameworks that are …
Personality Trait Recognition Through Deep Neural Temporal Modeling Of Non-Verbal Behavior, Kushal Vangara
Personality Trait Recognition Through Deep Neural Temporal Modeling Of Non-Verbal Behavior, Kushal Vangara
Theses and Dissertations
Personality research seeks to explain the wide range of human behaviors through stable, measurable traits. Human interactions are inherently rich and multidimensional, and analyzing behavioral data offers a promising path to uncover personality insights. The increasing convergence of psychology, computer science, and machine learning has fueled interest in computational approaches to personality assessment. Advances in sensing technologies have made it possible to capture fine-grained information about individuals’ behaviors and interactions in naturalistic and controlled environments. Automated audio-visual analysis techniques extract relevant behavioral cues, which machine learning models then interpret to infer underlying personality traits. This work provides a comprehensive overview …
Goal Attainment In Pmm2-Cdg: A New Approach Measuring Meaningful Clinical Outcomes, Sanne Verberkmoes, Gina L Mazza, Andrew C Edmondson, Fernando Scaglia, Seishu Horikoshi, Bryce Kuschel, Mirian C H Janssen, Jehan Mousa, Austin Larson, Rameen Shah, Georgia Mcdonald, Kyriaki Sarafoglou, Gerard Berry, Tamas Kozicz, Christina Lam, Eva Morava
Goal Attainment In Pmm2-Cdg: A New Approach Measuring Meaningful Clinical Outcomes, Sanne Verberkmoes, Gina L Mazza, Andrew C Edmondson, Fernando Scaglia, Seishu Horikoshi, Bryce Kuschel, Mirian C H Janssen, Jehan Mousa, Austin Larson, Rameen Shah, Georgia Mcdonald, Kyriaki Sarafoglou, Gerard Berry, Tamas Kozicz, Christina Lam, Eva Morava
Faculty, Staff and Students Publications
Patient-centered outcomes, including patient-reported outcomes (PROs), are increasingly important in healthcare and research, though their use in rare diseases remains limited. In disorders with significant phenotypic variation, selecting appropriate outcome measures is crucial to ensuring the relevance of clinical trials for the patient population. Phosphomannomutase 2-CDG (PMM2-CDG) involves a complex genotype-phenotype relationship, making it challenging to predict clinical outcomes and select reliable measures for clinical trials. Caused by biallelic pathogenic variants in the PMM2, PMM2-CDG displays highly variable clinical severity, underscoring the need for personalized outcome measures. One such so far unexplored, individualized approach is Goal Attainment Scaling (GAS), which …
Pediatric Predictive Artificial Intelligence Implemented In Clinical Practice From 2010 To 2021: A Systematic Review, Swaminathan Kandaswamy, Lindsey A Knake, Adam C Dziorny, Sean M Hernandez, Allison B Mccoy, Lauren M Hess, Evan Orenstein, Mia S White, Eric S Kirkendall, Matthew J Molloy, Philip A Hagedorn, Naveen Muthu, Avinash Murugan, Jonathan M Beus, Mark Mai, Brooke Luo, Juan D Chaparro
Pediatric Predictive Artificial Intelligence Implemented In Clinical Practice From 2010 To 2021: A Systematic Review, Swaminathan Kandaswamy, Lindsey A Knake, Adam C Dziorny, Sean M Hernandez, Allison B Mccoy, Lauren M Hess, Evan Orenstein, Mia S White, Eric S Kirkendall, Matthew J Molloy, Philip A Hagedorn, Naveen Muthu, Avinash Murugan, Jonathan M Beus, Mark Mai, Brooke Luo, Juan D Chaparro
Faculty, Staff and Students Publications
To review pediatric artificial intelligence (AI) implementation studies from 2010 to 2021 and analyze reported performance measures.We searched PubMed/Medline, Embase CINHAL, Cochrane Library CENTRAL, IEEE, and Web of Science with controlled vocabulary. Inclusion criteria: AI intervention in a pediatric clinical setting that learns from data (i.e., data-driven, as opposed to rule-based) and takes actions to make patient-specific recommendations; published between 01/2010 and 10/2021; must have agency (AI must provide guidance that affects clinical care, not merely running in the background). We extracted study characteristics, target users, implementation setting, time span, and performance measures.Of 126 articles reviewed as full text, 17 …
Maternal Dysbiosis Produces Long-Lasting Behavioral Changes In Offspring, Jacob Hudobenko, Claudia M Di Gesù, Patrick R Mooz, Joseph Petrosino, Nagireddy Putluri, Bhanu P Ganesh, Kristen Rebeles, Frank W Blixt, Venugopal R Venna, Louise D Mccullough
Maternal Dysbiosis Produces Long-Lasting Behavioral Changes In Offspring, Jacob Hudobenko, Claudia M Di Gesù, Patrick R Mooz, Joseph Petrosino, Nagireddy Putluri, Bhanu P Ganesh, Kristen Rebeles, Frank W Blixt, Venugopal R Venna, Louise D Mccullough
Faculty, Staff and Student Publications
Advanced maternal age (AMA) is defined as a pregnancy in a woman older than 35 years of age. AMA increases the risk for both maternal and neonatal complications, including miscarriage and stillbirth. AMA has also been linked to neurodevelopmental and neuropsychiatric disorders in the offspring. Recent studies have found that age-associated compositional shifts in the gut microbiota contribute to altered microbial metabolism and enhanced inflammation in the host. We investigated the specific contribution of the maternal microbiome on pregnancy outcomes and offspring behavior by recolonizing young female mice with aged female microbiome prior to pregnancy. We discovered that pre-pregnancy colonization …
Tau Depletion Diminishes Vascular Amyloid-Related Deficits In A Mouse Model Of Cerebral Amyloid Angiopathy, Nur Jury-Garfe, Enrique Chimal-Juárez, Henika Patel, Jonathan Martinez-Pinto, Kathryn Vanderbosch, Muriel D Mardones, Abigail Perkins, Gonzalo Viana Di Prisco, Yamil Marambio, Ruben Vidal, Brady K Atwood, Cristian A Lasagna-Reeves
Tau Depletion Diminishes Vascular Amyloid-Related Deficits In A Mouse Model Of Cerebral Amyloid Angiopathy, Nur Jury-Garfe, Enrique Chimal-Juárez, Henika Patel, Jonathan Martinez-Pinto, Kathryn Vanderbosch, Muriel D Mardones, Abigail Perkins, Gonzalo Viana Di Prisco, Yamil Marambio, Ruben Vidal, Brady K Atwood, Cristian A Lasagna-Reeves
Faculty, Staff and Students Publications
Introduction: Tau is essential for amyloid beta (Aβ)-induced synaptic and cognitive deficits in Alzheimer's disease (AD), making its downregulation a therapeutic target. Cerebral amyloid angiopathy (CAA), a major vascular contributor to cognitive decline, affects over 90% of patients with AD. This study explores the impact of tau downregulation on CAA pathogenesis.
Methods: We crossed the Familial Danish Dementia mouse model (Tg-FDD), which develops vascular amyloid, with tau-null (mTau-/-) mice to generate a CAA model lacking endogenous tau (Tg-FDD/mTau-/-). Behavioral, electrophysiological, histological, and transcriptomic analyses were performed.
Results: Tau depletion ameliorated motor and synaptic impairments, reduced vascular amyloid deposition, and prevented …
Psychiatric Genetics In The Diverse Landscape Of Latin American Populations, Estela M Bruxel, Diego L Rovaris, Sintia I Belangero, Gabriela Chavarría-Soley, Alfredo B Cuellar-Barboza, José J Martínez-Magaña, Sheila T Nagamatsu, Caroline M Nievergelt, Diana L Núñez-Ríos, Vanessa K Ota, Roseann E Peterson, Laura G Sloofman, Amy M Adams, Elinette Albino, Angel T Alvarado, Diego Andrade-Brito, Paola Y Arguello-Pascualli, Cibele E Bandeira, Claiton H D Bau, Cynthia M Bulik, Joseph D Buxbaum, Carolina Cappi, Nadia S Corral-Frias, Alejo Corrales, Fabiana Corsi-Zuelli, James J Crowley, Renata B Cupertino, Bruna S Da Silva, Suzannah S De Almeida, Juan F De La Hoz, Diego A Forero, Gabriel R Fries, Joel Gelernter, Yeimy González-Giraldo, Eugenio H Grevet, Dorothy E Grice, Adriana Hernández-Garayua, John M Hettema, Agustín Ibáñez, Iuliana Ionita-Laza, Maria Claudia Lattig, Yago C Lima, Yi-Sian Lin, Sandra López-León, Camila M Loureiro, Verónica Martínez-Cerdeño, Gabriela A Martínez-Levy, Kyle Melin, Daniel Moreno-De-Luca, Carolina Muniz Carvalho, Ana Maria Olivares, Victor F Oliveira, Rafaella Ormond, Abraham A Palmer, Alana C Panzenhagen, Maria Rita Passos-Bueno, Qian Peng, Eduardo Pérez-Palma, Miguel L Prieto, Panos Roussos, Sandra Sanchez-Roige, Hernando Santamaría-García, Flávio M Shansis, Rachel R Sharp, Eric A Storch, Maria Eduarda A Tavares, Grace E Tietz, Bianca A Torres-Hernández, Luciana Tovo-Rodrigues, Pilar Trelles, Eva M Trujillo-Chivacuan, Maria M Velásquez, Fernando Vera-Urbina, Georgios Voloudakis, Talia Wegman-Ostrosky, Jenny Zhen-Duan, Hang Zhou, Latin American Genomics Consortium, Marcos L Santoro, Humberto Nicolini, Elizabeth G Atkinson, Paola Giusti-Rodríguez, Janitza L Montalvo-Ortiz
Psychiatric Genetics In The Diverse Landscape Of Latin American Populations, Estela M Bruxel, Diego L Rovaris, Sintia I Belangero, Gabriela Chavarría-Soley, Alfredo B Cuellar-Barboza, José J Martínez-Magaña, Sheila T Nagamatsu, Caroline M Nievergelt, Diana L Núñez-Ríos, Vanessa K Ota, Roseann E Peterson, Laura G Sloofman, Amy M Adams, Elinette Albino, Angel T Alvarado, Diego Andrade-Brito, Paola Y Arguello-Pascualli, Cibele E Bandeira, Claiton H D Bau, Cynthia M Bulik, Joseph D Buxbaum, Carolina Cappi, Nadia S Corral-Frias, Alejo Corrales, Fabiana Corsi-Zuelli, James J Crowley, Renata B Cupertino, Bruna S Da Silva, Suzannah S De Almeida, Juan F De La Hoz, Diego A Forero, Gabriel R Fries, Joel Gelernter, Yeimy González-Giraldo, Eugenio H Grevet, Dorothy E Grice, Adriana Hernández-Garayua, John M Hettema, Agustín Ibáñez, Iuliana Ionita-Laza, Maria Claudia Lattig, Yago C Lima, Yi-Sian Lin, Sandra López-León, Camila M Loureiro, Verónica Martínez-Cerdeño, Gabriela A Martínez-Levy, Kyle Melin, Daniel Moreno-De-Luca, Carolina Muniz Carvalho, Ana Maria Olivares, Victor F Oliveira, Rafaella Ormond, Abraham A Palmer, Alana C Panzenhagen, Maria Rita Passos-Bueno, Qian Peng, Eduardo Pérez-Palma, Miguel L Prieto, Panos Roussos, Sandra Sanchez-Roige, Hernando Santamaría-García, Flávio M Shansis, Rachel R Sharp, Eric A Storch, Maria Eduarda A Tavares, Grace E Tietz, Bianca A Torres-Hernández, Luciana Tovo-Rodrigues, Pilar Trelles, Eva M Trujillo-Chivacuan, Maria M Velásquez, Fernando Vera-Urbina, Georgios Voloudakis, Talia Wegman-Ostrosky, Jenny Zhen-Duan, Hang Zhou, Latin American Genomics Consortium, Marcos L Santoro, Humberto Nicolini, Elizabeth G Atkinson, Paola Giusti-Rodríguez, Janitza L Montalvo-Ortiz
Faculty, Staff and Students Publications
Psychiatric disorders are highly heritable and polygenic, influenced by environmental factors and often comorbid. Large-scale genome-wide association studies (GWASs) through consortium efforts have identified genetic risk loci and revealed the underlying biology of psychiatric disorders and traits. However, over 85% of psychiatric GWAS participants are of European ancestry, limiting the applicability of these findings to non-European populations. Latin America and the Caribbean, regions marked by diverse genetic admixture, distinct environments and healthcare disparities, remain critically understudied in psychiatric genomics. This threatens access to precision psychiatry, where diversity is crucial for innovation and equity. This Review evaluates the current state and …
Navigating Insulin Access For Pediatric Type 1 Diabetes: Caregivers' Experiences And Challenges, Ella Anderson
Navigating Insulin Access For Pediatric Type 1 Diabetes: Caregivers' Experiences And Challenges, Ella Anderson
Doctoral Dissertations
Between 2012 and 2018, the annual 14% increase in insulin prices made Type 1 Diabetes (T1D) the most expensive chronic health condition, significantly raising out-of-pocket costs for uninsured or underinsured individuals in the United States (Hayes & Farmer, 2020; Willner et al., 2020). This study utilized a qualitative content analysis methodology to explore the challenges and experiences of parents with children diagnosed with T1D with accessing insulin for their child. Five participants from various areas of the United States responded to open-ended questions both in person and via Zoom. The analysis revealed three main themes: pragmatics of managing diabetic care, …