Digital Commons Network^™

Spatiotemporal Changes In The Imperiled And Diverse Mussel Assemblage Of The Spring River In Kansas In Response To Known And Emerging Pollutants, Joshua Holloway

Electronic Theses & Dissertations

Kansas was historically home to 50 species of freshwater mussels, of which 42 remain extant. The Spring River of southeastern Kansas is home to 34 of the remaining 42 mussels, many of which are imperiled. Elevated metal concentrations that resulted from past lead and zinc mining in the Tri-State Mining District historically imperiled Spring River mussels, but this threat has abated over the last 20 years. Ammonia pollution may have replaced the threat of metals, however, with potentially severe consequences for Spring River mussels. Our objectives were to evaluate contemporary mussel assemblage structure, in addition to spatiotemporal trends in the …

Effect Of Traumatic Brain Injury On Quality Of Life, Mohammad A. Al Rjoob

Theses

Traumatic brain injury (TBI) results from external events, such as falls and motor vehicle accidents leading to brain damage. This study investigated quality of life (QoL) in individuals with TBI and its relation to demographic and clinical variables, including gender, age, educational level, time since TBI onset, fatigue, depression and cognitive function. Twelve individuals with TBI participated in this cross-sectional study. Quality of life was assessed using Quality of Life after Brain Injury and ASHA Quality of Communication Life Scale measures. Fatigue was measured using the Fatigue Severity Scale, depression was measured with the Geriatric Depression Scale, and cognitive function …

Gender Knobs, Jordan Faye Bardgett

Theses

Gender Knobs is a performance art piece that tells the histories of both the technology surrounding pitch shifting devices like the vocoder as well as well as the personal history of the voice of the performer, Jordan, regarding their queer identity as non-binary trans woman. The performance is a combination of lecture, personal storytelling, and sound performance within a theatrical setting with musical accompaniment and projected visuals.

A Costuming Carol: A Costume Design Thesis On A Christmas Carol, Aleka Fischer

Theses

This thesis is a collection of research, analysis, design, and production work done for the costumes for A Christmas Carol. The play production took place in the McLeod Theater at Southern Illinois University from December 5th- December 8th, 2024. The play was written by Darwin Reid Payne and published in 1981. It is an adaptation of the novella A Christmas Carolby Charles Dickens. Chapter 1 contains the research and script analysis used to make design decisions for this production. Chapter 2 documents the design process, and how the costume design evolved between the first and final design meetings. Chapter 3 …

Elliptic Curves And Their Applications In Cryptography, Mercedes Danange Moll

Theses

This thesis explores the mathematical foundations and cryptographic applications ofelliptic curves. To understand elliptic curves, we start by introducing group theory, ring theory, and field theory. Then, we dive into elliptic curves, their algebraic structure, and the group law defined on their points. We then examine elliptic curves over finite fields, leading to the discrete logarithm problem and key cryptographic applications such as Weil Pairings, the Diffie-Hellman key exchange, Digital Signature Algorithm, and Elliptic Curve Digital Signature Algorithms. Using the theory and its application, this thesis highlights the significance of elliptic curves in modern cryptography.

Black Women During The Great Migration: Transitions From Sharecropping To Black Metropolis, Ryan Daye

Dartmouth College Master’s Theses

The origin of the dissertation came about as me being the only southerner within the group of individuals completing the MALS Program. While studying Cultural studies, I began to take a focus on the Great Migration of black Americans migrating from the South to other regions of the United States. As a southerner, I was aware of the migration patterns but never went in-depth on the subject because I felt no connection. While studying, I noticed the perception of black women who were being used as subjects. Women who were being forced out of their southern situations because of segregation, …

Fiction For Feminist Jurisprudence: The Power Of The Literary Reality In Feminist Legal Scholarship, Elia M. O'Hara

All Theses And Dissertations

This paper asks what can it mean when we take women's stories and their realities seriously and allow them to paint a more nuanced portrayal of life and law? I will argue that a feminist legal theory — which aims to recognize and remedy the subordination of women seen through the legal system — needs a literary counterpart. Furthermore, I will argue that subtleties and nuances that make literature so alluring to us can also benefit in part from the structure and clarity that feminist jurisprudence can offer. One of my central aims is to show that we can create …

Pastoral Unity Community Engagement Of Shiprock Area Ministry Association In Shiprock, New Mexico, Rosalind Ann Russell

Doctoral Dissertations and Projects

This praxis project examines the Shiprock Area Ministry Association (SAMA), a pastoral group which represents different religious denominations of faith in the community. SAMA is located on the Navajo Indian reservation in Shiprock, New Mexico and has struggled to return as a group amid the post COVID-19 pandemic. Since its founding as an organization, the group has gathered for support in unity, prayer, and engaged in activities in Shiprock. The return of SAMA members and new membership is to include pastor spouses, church workers, and ministers within a 15-mile radius. The Hershey and Blanchard (2001) Situational Leadership Self-Assessment will be …

Parent-Child Relationship Satisfaction Influences After Solution-Focused Brief Therapy Is Delivered To An Anxious Child: A Quantitative Analysis From The Parent’S Perspective, Michelle S. Saunders

Doctoral Dissertations and Projects

Social media culture is prevalent today, which encourages inclusion, exclusion, self-doubt, bullying, and other positive and negative social and emotional learning (SEL). Children are exposed to social media which has both positive and negative daily consequences. The prognosis and remission rates of anxiety are declining, with the risk of maladaptive regulation symptoms. A strong positive foundation of SEL promotes core identity, beliefs, morals, values, and interpersonal growth throughout a lifespan. Parenting styles (parent), the child’s psychosocial development (child), religious morals and values (religion), and psychotherapy (therapy) are influences of change that can help create healthy SEL. Therapy interventions are sought …

The Overrepresentation Of Juveniles Of Color In The Criminal Justice System, Shimila A. Stewart

Doctoral Dissertations and Projects

The criminal justice system foundation historically was based on discriminatory and racial undertones for people of color; hence, the significance of mass incarceration in the United States. The juvenile justice system often parallels and mimics the adult penal system. Thus, many of the same racial disparities continue to exist in the juvenile system, as do the adult system. The prevalence of racial disparities within the juvenile justice system has led to the overrepresentation of juveniles of color. Systemic racism has been significant to the overrepresentation of juveniles of color in the juvenile justice system. There are extenuating barriers and disadvantages …

The Impact Of Waste Management On Green Spaces And Community Well-Being: A Case Study Of Wa Municipality, Upper West, Ghana, Al-Rauf Mahama

Sustainability and Social Justice

Urbanization in Low- and Middle-Income Countries such as Ghana has placed immense pressure on infrastructure, waste management systems, and urban green spaces. This study examines the impact of waste management practices on green spaces and community well-being in Wa Municipal, focusing on four communities: Dondoli, Mangu, Dokpong, and Bamahu. Using a participatory research approach, data collected from waste management authorities, sanitation agencies, and residents were used to examine waste composition, health impacts, and community engagement in environmental sustainability. The findings reveal that organic waste and plastics dominate waste composition, with inadequate disposal practices contributing to pollution and health issues, including …

Assessing The Effectiveness And Value Of Information On Southern Illinois University Carbondale's Center For Education's (Cie) Website, Herty Tinadu

Research Papers

Abstract

The internationalization of higher education has grown significantly over the past three decades, with international students playing a crucial role in fostering academic, cultural, and economic development in host countries. University websites are pivotal in supporting international student mobility, serving as primary sources of information during the decision-making process. This study aims to evaluate the effectiveness of the Center for International Education (CIE) website at Southern Illinois University Carbondale (SIUC) in disseminating information and providing a positive user experience for international students.

The study examines factors influencing website usability, such as content clarity, website architecture, user interface design, and …

Dual-Criterion Dose Finding Designs For Phase I Clinical Trials, Yunlong Yang

Dissertations and Theses (Open Access)

The primary objective of Phase I oncology trials is to assess the safety and tolerability of novel therapeutics. Conventional dose escalation methods identify the maximum tolerated dose (MTD) based on dose-limiting toxicity (DLT). However, as cancer therapies have evolved from chemotherapy to targeted therapies, these traditional methods have become problematic. Many targeted therapies rarely produce DLT and are administered over multiple cycles, potentially resulting in the accumulation of lower-grade toxicities, which can lead to intolerance, such as dose reduction or interruption. To address this issue, we proposed dual-criterion designs that find the MTD based on both DLT and non-DLT-caused intolerance. …

Unraveling Epigenetic Mechanisms That Regulate Breast Cancer Lung Metastatic Relapse By Rewiring The Immune Microenvironment, Jayanta Mondal

Dissertations and Theses (Open Access)

Metastasis accounts for >90% of cancer-related deaths and thwarting metastasis is widely considered to be the “Holy Grail” of cancer treatment. Breast cancer is the most common cause of cancer-related death among women and is characterized by its proclivity to spread to distant secondary organs like the lungs, and the brain. These disseminated tumor cells lie dormant at the secondary site and can undergo metastatic relapse. Epigenetic alterations are a predominant hallmark of cancer, however, its role in facilitating reawakening of dormant cancer cells and the subsequent metastatic relapse remains to be elucidated. To address this gap of knowledge, we …

Developing Novel Therapies Targeting The Tumor Microenvironment Of Aggressive Breast Cancer, Lan T H Phi

Dissertations and Theses (Open Access)

Triple-negative breast cancer (TNBC) and inflammatory breast cancer (IBC) are the most aggressive breast cancer subtypes. The tumor microenvironment (TME) is critical in driving these aggressive breast cancers' clinical phenotype and aggressiveness. Therefore, we explored novel actionable targets and complementary therapies targeting the TME to improve the outcomes of patients with these cancers.

In this thesis, we identified AXL as a potential therapeutic target in IBC due to its role in generating an immunosuppressive TME. Indeed, inhibiting the AXL pathway suppresses IBC tumor growth and reduces M2 macrophage populations in various mouse models. Mechanistically, AXL facilitates the polarization of M2 …

The Extracellular Domains Of The Ampa, Kainate, And Orphan Delta Receptor Regulate Channel Gating In Distinct Ways, Cuauhtemoc Ulises Gonzalez

Dissertations and Theses (Open Access)

The ionotropic glutamate receptors are ligand-gated cationic channels essential for neuroplasticity and neurological functions such as learning, memory, behavior, cognition, and motor coordination. Mutations in these channels are linked to various disorders including autism, ataxia, and epilepsy, making them compelling pharmacological targets. Within this family, the α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) and kainate receptor mediate their function through fast glutamate-gated ionotropic activity, which needs precise structural changes to perform properly. While Cryo-EM structures have provided snap shots of these proteins, questions remain regarding the dynamics across conformations and individual roles of the extracellular amino-terminal and agonist binding domain in dictating function. …

Relationship Between Processing Body Formation, Epithelial-To-Mesenchymal Transition, And Invasion In Lung Adenocarcinoma, Amanda Warner

Dissertations and Theses (Open Access)

Lung cancer is the leading cause of cancer-related deaths in the United States, largely due to its ability to metastasize. Epithelial-to-mesenchymal transition (EMT) is a process that enhances the ability of cells to lose their cell-cell contacts, invade, and enter the blood stream which are essential during metastasis. Many transcriptional gene programs are altered during EMT such as activation of mesenchymal transcription factors, like ZEB1, and enhanced response to the TGFβ1 cytokine. In oncogenic contexts, TGFβ1 enhances the formation of processing-bodies (P-bodies) where P-body proteins are required for invasion in multiple cancerous cell lines. P-bodies are a type of ribonucleoprotein …

Rod Photoreceptor Regeneration In A Zebrafish Model With Retinitis Pigmentosa, Eyad Shihabeddin

Dissertations and Theses (Open Access)

A cellular hallmark of inherited retinal degenerative diseases is progressive loss of photoreceptors until one is completely blind. Unlike mammalian models, Zebrafish have the ability to naturally regenerate their neurons after injury or disease is detected. We have generated a zebrafish model with the most common autosomal dominant form of the inherited retinal degenerative disease known as Retinitis Pigmentosa. We utilize immunohistochemistry, single-cell RNA sequencing, several analysis tools, behavioral assays and oligonucleotides to characterize our zebrafish model and identify the transcription factors necessary for rod photoreceptor regeneration. We show that our zebrafish model has continuous degeneration and regeneration of rod …

The Gut Microbiome As A Novel Approach For Reversing Long-Term Inflammation And Accelerated Aging Across The Lifespan, Janelle M. Korf

Dissertations and Theses (Open Access)

Introduction: Neonatal hypoxic-ischemic encephalopathy (HIE) arises from disrupted perinatal cerebral oxygenation and perfusion. It is a leading global cause of infant death and disability which disproportionally affects males. Like adult stroke, HIE initiates a rapid influx of inflammatory cells across the blood brain barrier and a loss of microglial homeostasis. Persistent peripheral inflammation in children with a history of HIE is recognized but its ramifications, including accelerated aging, are poorly understood. As this coincides with critical stages of brain development, interventions started months or years post-injury may still improve survivors’ quality of life. One promising intervention is to manipulate the …

Combined Inhibition Of Lysine-Specific Demethylase 1 And Kinase Signaling As A Preclinical Treatment Strategy In Glioblastoma, Lea Stitzlein

Dissertations and Theses (Open Access)

Glioblastoma is the most common primary malignant brain tumor in adults, with limited treatment options resulting in a poor prognosis. Lysine-specific demethylase 1 (LSD1) is overexpressed in glioblastoma and contributes to tumor growth and treatment resistance. Inhibitors of LSD1 have shown preclinical promise but have had limited clinical development for glioblastoma. Given the frequent kinase pathway alterations in glioblastoma, the interplay between LSD1 inhibition and kinase signaling pathways was investigated to identify vulnerabilities that could be exploited through rationally designed combination therapies. We hypothesized that LSD1 inhibitors would activate kinase signaling pathways, such as MAPK, and the addition of kinase …

Impact Of Personal And Family History Of Huntington's Disease On The Decision And Ability To Obtain Life, Long-Term Care, And Disability Insurance, Karli Livingston

Dissertations and Theses (Open Access)

Huntington’s disease (HD) is an inherited, neurodegenerative condition characterized by a clinical triad of motor, cognitive, and psychiatric symptoms. Individuals diagnosed with HD manifest characteristic symptoms of the disease including motor and cognitive changes, and they may or may not have undergone genetic testing to confirm the diagnosis. Individuals at-risk for HD are those who have not yet undergone genetic testing for HD, but have a first- or second- degree relative diagnosed with the disease. Genetic testing for HD is categorized into two forms: predictive and confirmatory. However, many individuals choose not to pursue testing due to a fear of …

The Influence Of Scientific, Genetic, And Health Literacy On Carrier Screening Decision-Making, Brenna D. Albracht

Dissertations and Theses (Open Access)

For those wishing to assess their reproductive risks and make informed decisions in their reproductive planning, carrier screening for autosomal recessive and X-linked conditions, as well as cell-free DNA (cfDNA) screening for aneuploidy, are recommended during pregnancy. Despite similarities in purpose, sample requirements, insurance coverage, and safety, a lower percentage of individuals elect carrier screening than cfDNA screening, suggesting there may be a disconnect in what patients perceive as valuable information for their pregnancy. Previous studies have attempted to explain the factors associated with carrier screening uptake or decline; however, no models have yet accounted for a patient’s literacy level …

Achieving The Practice-Based Competencies: Are More Than 50 Cases Needed?, Farren Lopez

Dissertations and Theses (Open Access)

Genetic counseling graduate programs are required to provide didactic coursework and fieldwork experiences to foster development of the practice-based competencies (PBCs) in trainees. Currently, every graduating trainee must log a minimum of 50 participatory encounters to demonstrate readiness for entry-level practice of the PBCs. Previous studies have noted that many trainees exceed the 50-case standard, raising the question of whether this minimum satisfies the training needs of every student. To assess the perceived number of encounters needed for graduates to independently perform the PBCs, a survey was administered to 2023 and 2024 graduates of North American genetic counseling training programs. …

Role Of Mir-4732-3p In Breast Cancer Brain Metastasis And Brain Metastatic Tumor Microenvironment, Munazza Samar Khan

Dissertations and Theses (Open Access)

In this study, we aimed to identify microRNAs (miRNAs) that may play important roles in breast cancer brain metastasis (BCBM). To this end, we conducted miRNA-sequencing of extracellular vesicles isolated from the serum samples of 6 BCBM patients and 8 Stage I/II/III breast cancer patients, and identified 49 circulating miRNAs that were upregulated in BCBM patients compared to Stage I/II/III breast cancer. Upon further analysis, we identified miR-4732-3p to be upregulated in brain-tropic triple-negative breast cancer (TNBC) cell lines, compared to parental lines. MiR-4732-3p overexpression increased metastatic properties of TNBC cells, including proliferation, migration, invasion, and maintenance of a mesenchymal …

Uncovering A Fundamental Mechanism Underlying Female Oocyte Quality And Rasopathies Using C. Elegans As A Model System, Han Bit Baek

Dissertations and Theses (Open Access)

Signaling pathways are molecular networks that allow cells to communicate between and within themselves. They are crucial for the coordination of diverse cellular processes and are the molecular mechanism in which cells sense and respond to their environment. RAS (Rat Sarcoma) is a small GTPase that transmits extracellular growth factor signals through a downstream kinase cascade and ERK (Extracellular-signal regulated kinase) is the terminal kinase, and it controls cellular processes such as proliferation, differentiation, and survival by phosphorylating its downstream effectors. This post translational modification regulates the effector by modulating its activity, levels, and/or interaction with other molecules. Given the …

Mhc Class I Tyrosine Phosphorylation Site Y320 Augments Cd8+ T Cell Priming, Effector Function, And Memory Response, Yimo Sun, Gregory A Lizee, Yitao Tang, Priscilla Ortiz, R Eric Davis

Dissertations and Theses (Open Access)

The cytoplasmic domain of MHC class I (MHC-I) molecules contains a single, highly conserved tyrosine residue (Y320). In previous work, we found that mice expressing a Y320F-mutated form of H-2K^b had reduced capacity to generate K^b-restricted cytotoxic T lymphocyte (CTL) responses following viral infection, due (at least in part) to defects in endolysosomal trafficking of H-2K^b and antigen cross-presentation by dendritic cells (DCs). In this study, we investigated whether there are additional, post-presentation dependencies on Y320 for T-cell priming. We engineered both human- and mouse-derived antigen-presenting cells (APCs) to express either wild-type MHC-I or variants of …

Neural Activity Within And Between Visual And Executive Areas Is Modulated Post-Locomotion In Rhesus Macaques, Sergey Egranov

Dissertations and Theses (Open Access)

Physical activity has been shown to benefit cognitive and mental health by improving cerebrovascular perfusion and regulating hormone-mediated processes on a systemic level. However, the acute effects of physical activity, such as locomotion, on the neuronal circuits underlying cognitive processes have yet to be fully characterized. This body of work seeks to rectify this gap in knowledge through analysis of how both behavioral performance and neuronal activity signatures in visual and executive brain regions are modulated post-locomotion in rhesus macaques.

To this end, we performed high-yield electrophysiological recordings simultaneously from area V4, a mid-tier visual cortical region, and the dorsolateral …

Investigating Metabolic And Mitochondrial Adaptations Triggered By Blood Flow During The Endothelial-To-Hematopoietic Transition, Paulina Horton

Dissertations and Theses (Open Access)

Hematopoietic stem cell (HSC) transplant is the standard of care for many hematologic diseases. However, many patients cannot benefit from this potentially curative treatment because they cannot find a suitable donor, contributing to a high level of unmet need. Recently, bona fide HSCs capable of robust engraftment and differentiation have been generated from iPSCs utilizing wall shear stress (WSS) to help promote HSC generation. However, the mechanisms through which WSS regulates hematopoiesis remain poorly understood. Scientists, therefore, continue to look for the mechanotransduction pathways that promote hematopoiesis, and key answers may lie in examining the role of extrinsic factors that …

Felt Obligation, Knowledge Sharing And Innovation Performance: The Role Of Team Performance Goal Orientation, Zenan Wen

Dissertations and Theses Collection (Open Access)

In today’s dynamic work environment, individual innovation is vital for organizational success. While knowledge sharing is a recognized driver of innovation, less is known about the internal motivational forces that compel employees to share knowledge. Drawing on the role identity theory, this research examines how felt obligation—a normative motivation, whereby individuals, based on their perceived role identities, believe they should care about organizational goals and contribute to them—encourages knowledge sharing and subsequently enhances innovation performance. Furthermore, I theorize that this relationship is strengthened in teams with higher performance goal orientation (TPGO), where norms and expectations regarding performance excellence amplify the …

The Dynamics Of Power Transfer In Organizations: Examining Downward Deference And Its Workplace Consequences, Hoang Bao My Nguyen

Dissertations and Theses Collection (Open Access)

This dissertation examines managerial power transfer as a core mechanism through which less-hierarchical management unfolds in organizations. While traditional management research has emphasized formal authority and top-down control, emerging organizational forms increasingly call on managers to share power with subordinates. Despite growing interest in constructs like empowerment, delegation, and participative leadership, the phenomenon of power transfer remains conceptually fragmented and undertheorized.

To address this, the dissertation defines power transfer as the intentional redistribution of authority, control, or resources by powerholders to lower-power individuals. Chapter 1 develops a typology of power transfer behaviors, organized along two key dimensions: extent of control …