Digital Commons Network^™

Examining Hospital Mergers And Acquisitions From A Supply Chain Perspective: Applications For Public Hospitals In Louisiana, Jamar O'Neal Powell

Walden Dissertations and Doctoral Studies

Public hospitals undergoing mergers and acquisitions (M&As) often encounter complex supply chain challenges that disrupt operations, decrease efficiency, and jeopardize financial sustainability. Ineffective post-merger integration may result in increased costs, lower employee performance, and diminished patient satisfaction. The purpose of this quantitative study was to examine whether key post-merger supply chain strategies: supply chain integration, vendor consolidation, inventory rationalization, and healthcare landscape evolution (independent variables) were significantly associated with hospital performance outcomes: supply chain efficiency, employee performance, employee satisfaction, patient care experiences, and financial efficiency (dependent variables). Grounded in organizational change theory, this study utilized a secondary data analysis design …

Developing Organizational Leaders’ Personal Mastery Through Emotional Intelligence Training In The Workplace: An Interpretive Phenomenological Analysis, Billie Bruce Relyea

Walden Dissertations and Doctoral Studies

Mayer and Salovey, seminal researchers of emotional intelligence (EI), indicated that the ability measures of EI are still evolving, and the mental abilities involved in EI remain to be determined. Organizational leaders should understand this intention as the key to developing EI and personal mastery, resting firmly upon attaining accurate self-awareness as a prerequisite for human behavior. The purpose of this interpretive phenomenological analysis was to gain an understanding of the socially constructed realities of the lived experiences of organizational leaders and organizational development specialists who have completed Ennea International’s 5 Lens Development Platform (5LDP). Bandura’s social cognitive theory grounded …

Staff Education To Address Communication In Correctional Healthcare, Pamela Renee Bredy

Walden Dissertations and Doctoral Studies

This doctoral project was a staff education initiative focused on enhancing staff knowledge of Situation Background Assessment Recommendations (SBAR) communication through structured educational intervention in correctional healthcare settings. The practice problem centered on significant deficiencies in standardized communication. The practice-focused question was, Will implementing staff education on SBAR communication increase staff knowledge and confidence? I aimed to enhance staff communication and knowledge through SBAR implementation using live sessions, hands-on practice, and reference materials.

Parapinopsin: A Photoswitchable Inhibitory Gpcr For Two-Photon Optogenetics, Bobbie J. Brown

Arts & Sciences Graduate Student Theses and Dissertations

The development of optogenetic tools has greatly advanced the capability of researchers to understand the connection between neuronal activity and behavior. Optogenetics makes use of opsins, which are light activated ion-channels, ion pumps, or G-Protein coupled receptor (GPCR-based) proteins used to regulate cellular activity. Coupled with technological advances in genetics and optical physics/microscopy, optogenetics can be used to control specific populations of cells in a time-locked, spatially specific manner. The experiments possible with optogenetics depend largely on the capabilities and limitations of the opsin used; thus, there have been continuous efforts to design and employ new opsins with a variety …

Circuit-Specific Vulnerability In A Mouse Model Of Alzheimer's Disease, Samuel Brunwasser

Arts & Sciences Graduate Student Theses and Dissertations

The relationship between brainwide functional decline and accumulation of pathological protein aggregates in Alzheimer’s disease (AD) is complex and not well understood. A set of highly interconnected cortical regions known as the Default Mode Network (DMN) exhibits selective vulnerability to both functional decline and amyloid beta (Aβ) plaques in early AD. One possibility is that early Aβ accumulation in the DMN drives vulnerability. However, it is unknown whether there is something intrinsic to neuronal projections within the DMN that biases these circuits towards dysfunction. In this dissertation, I describe the development of a multisite in vivo electrophysiology pipeline for chronic …

Induced Cd8a Identifies Enhanced Human Nk Cell Il-15-Induced Proliferation And Metabolism And Modulates Nk Cell Activation, Celia Cubitt

Arts & Sciences Graduate Student Theses and Dissertations

Natural Killer (NK) cells are cytotoxic innate lymphoid cells that play an important role in the surveillance and elimination of virally-infected and malignantly-transformed cells. These primary effector functions are achieved by producing cytokines and chemokines which activate and recruit additional immune effectors, as well as direct cytotoxic killing via perforin and granzymes. NK cell function is tightly regulated by a balance of germ-line encoded activating, inhibitory, co-stimulatory, and cytokine receptors expressed at the cell surface. Through these activating and inhibitory receptors, NK cells recognize and kill targets without prior sensitization through the loss of self-identifying molecules such as major histocompatibility …

Parental Guidance Suggested: Genetic, Epigenetic, And Environmental Factors Shape Allele-Specific Gene Regulation In Metabolic Traits, Celine Louise St. Pierre

Arts & Sciences Graduate Student Theses and Dissertations

Deciphering the “genotype to phenotype” map is a crucial goal of biology. We will not improve our ability to predict phenotypes from DNA sequences until we better incorporate epigenetic and environmental variation into our models of human health and disease. Genes are typically presumed to express both parental alleles equally, but genetic and epigenetic factors can cause one allele to function differently than the other (e.g. expressed or silenced more). These allele-specific imbalances can alter the final composition of a gene’s transcriptional product and ultimately shape phenotypes. Allele-specific effects have widespread impacts on complex traits, but how environmental signals contribute …

Expanding The Druggable Proteome By Integrating Deep Learning With Molecular Simulations To Predict Cryptic Pockets, Artur Meller

Arts & Sciences Graduate Student Theses and Dissertations

Of the protein structures deposited in the Protein Data Bank, less than half have pockets suitable for the binding of drugs. Even when proteins contain pockets in their ground state structures (e.g., the nucleotide-binding active site in myosin motors), achieving specificity remains a central challenge in drug design as many protein families share common structural motifs. Cryptic pockets are cavities absent in ligand-free experimental structures that form due to protein fluctuations in solution. They provide a means to specifically target proteins currently considered undruggable. While cryptic pockets are alluring drug targets, it remains difficult to predict which proteins will form …

Young-Onset Diabetes Poses A Greater Risk Of End-Stage Kidney Disease Than Cardiovascular Disease And Stroke: A Retrospective Cohort Study Of Uk Biobank (Ukb), Debasish Kar

Peninsula Medical School

No abstract provided.

Reverse Engineering Of Binary Programs Using Graph Attention Networks, Sai Nikhila Kanigiri

Master's Theses

Understanding the functionality and behavior of binary code is essential for many software engineering tasks, including malware analysis, vulnerability detection, and program optimization. However, automating this process is challenging due to the complexity of machine code and the significant manual effort required from experienced software engineers. In this paper, we present BinGAT (Reverse Engineering of Binary Programs using Graph Attention Networks), a method for classifying binary programs into algorithmic categories using Graph Attention Neural Networks (GNNs) based on their Control-Flow Graphs (CFGs). Given a binary program, BinGAT extracts its CFG through static analysis and transforms the assembly instructions within each …

Sirt6 Deficiency Promotes Senescence And Age-Associated Intervertebral Disc Degeneration In Mice, Pranay Ramteke, Bahiyah Watson, Mallory Toci, Victoria A Tran, Shira Johnston, Maria Tsingas, Ruteja A Barve, Ramkrishna Mitra, Richard F Loeser, John A Collins, Makarand V Risbud

2020-Current year OA Pubs

Intervertebral disc degeneration is a major risk factor contributing to chronic low back and neck pain. While the etiological factors for disc degeneration vary, age is still one of the most important risk factors. Recent studies have shown the promising role of SIRT6 in mammalian aging and skeletal tissue health, however its role in the intervertebral disc health remains unexplored. We investigated the contribution of SIRT6 to disc health by studying the age-dependent spinal phenotype of mice with conditional deletion of Sirt6 in the disc (Acan

Society’S Press: Designing A Digital Commons To Promote Critical Thought And Civil Discourse, Louis Driver

Honors College Theses

This thesis proposes the design of a new digital commons aimed at counteracting the negative incentives that currently dominate online discourse. This paper outlines the research and design of a system that promotes informative, medium-length, user-generated content, emphasizing thoughtful communication over virality. Inspired by academic peer-review practices, the proposed platform will implement a community-driven moderation model to reduce low-quality contributions and foster constructive feedback.

Recent Trends In Medical Education To Sustain An Effective Practice - A Systematic Review, Sharon Pricilla Jeevan Kumar Leela Ms., Amtuz Zehra Dr, Ayesha Siddiqhha Mukthar Ms

International Journal of Health and Allied Sciences

Learning processes in medical practices in medicinal schools put more emphasis on the hard sciences than they do on developing soft skills like empathy and communication. For this reason, the medical humanities emerged to provide a "different" take on the creative process. Medical ethics, the doctor-patient relationship, clinical research, mental illness, and professionalism are just a few of the topics that have been utilized to discuss in medical school. A strong connection between classroom learning and clinical experience is crucial for medical school graduates. Students graduating from a medical program are expected to have experience with patient care, clinical procedures, …

Exploring The Vitamin D Receptor Gene Polymorphisms: Implications For Disease Susceptibility, Thrupthi Rai, Sushma M, Jadeppa G, Suma M N, Swetha Nk

International Journal of Health and Allied Sciences

The Vitamin D endocrine system, comprising of Vitamin D, its receptor (VDR), and metabolic enzymes, coordinates essential physiological functions influencing skeletal metabolism, immune response, and various diseases including osteoarthritis, cancer, and obesity. Understanding the impact of genetic variations, particularly the VDR gene, on disease susceptibility is crucial. This paper provides a comprehensive overview of Vitamin D metabolism, deciphering how the VDR gene works and understanding how different versions of the gene impact complex diseases. It provides a brief overview of the association between VDR gene polymorphisms in inflammatory disease, hypertension, osteoporosis, hyperparathyroidism, coronary artery disease, asthma, cancer, and infectious diseases. …

A Comprehensive Review Of Ethical Guideline On Biomarker Application And Research, Nurjamal Hoque

International Journal of Health and Allied Sciences

Background:

Biomarker research is essential for personalized medicine, providing insights into disease causes, diagnostics, and treatment methods. However, informed consent, privacy, data protection, and vulnerable population impacts are major ethical considerations in this quickly developing profession.

Method

This thorough overview analyzes existing legal frameworks, such as HIPAA and GDPR, and assesses growing ethical criteria for biomarker research and implementation. A examination of case studies, ethical considerations, and regulatory rules examines how biomarker research has handled sensitive data and protected participant rights.

Result

Key results indicate that informed consent is a significant issue in biomarker research owing to its complexity and …

Making Training Stick: Transferring Learning Back To The Job, Amanda Woods Herron, Phoebe Hessen, Katelyn J. Cavanaugh, Wykesha C. Hayes, Victor Hassid, Courtney L. Holladay

Advances in Cancer Education and Quality Improvement

Communication remains a central priority in healthcare, making it a key component of many training efforts. The positive impacts of communication training in healthcare settings have been well-established; however, the linkage of communication training to key organizational outcomes (e.g., engagement, performance, retention) remains underexplored. The present study investigated a training program targeting interpersonal communication within a large academic oncology center. We drew from Cognitive Load Theory and Social Cognitive Theory to evaluate the impact of the training on participant learning (retention and utilization), transfer (communication, decision-making, performance), and results-level outcomes (engagement and turnover). The program centered around a personality framework …

The Fair Credit Reporting Act, David J. Fletcher

Maine Law Review

With the increasing importance of credit in the United States economy, a specialized group of agencies has developed to supply businesses with personal information on consumers. These reporting agencies come in two basic forms. Credit bureaus deal with purely economic data and use a file system to develop their reports. Investigative consumer reporting agencies issue a more comprehensive report which is generally the result of a field investigation. Because of subjective judgments, errors of identification, or use of untrustworthy sources, consumer reports often are inaccurate. The direct result of most inaccuracy is harm to the report's subject, the consumer. An …

Privileged Communications: A Case By Case Approach, Josephine Citron

Maine Law Review

Privileged communications are communications which, because of a special relationship, are protected from revelation during the course of litigation. In the past, grants of privilege have been made by reference to professional groups rather than to the content of the particular communication, resulting in inconsistent treatment. Some professionals have secured absolute privileges for their relationships while others have been partially or totally unsuccessful. The inconsistencies are most clearly demonstrated by examining grants of privilege to medical, psychotherapeutic, and social work personnel, although it is not intended that the case by case approach suggested in the proposed statute at the end …

Enhancing Mental Toughness And Strength And Conditioning Performance In Collegiate Athletes Through Pressure Training, Chad Workman, Andreas Stamatis

International Journal of Exercise Science

International Journal of Exercise Science 18(4): 456-469, 2025. This study is the first to investigate the role of mental toughness (MT) in predicting strength and conditioning (S&C) performance outcomes and the impact of pressure training (PT) on MT development among NCAA athletes. A women’s Division I field hockey team (n = 15) participated in five 1-hour sessions focused on psychological skills training to enhance MT, followed by two S&C sessions under PT conditions. Using the Mental Toughness Index, MT was assessed after the workshops/before PT and following PT. Regression analysis revealed that pre-PT MT scores predicted S&C performance outcomes …

Meningococcal Sepsis In Pregnancy: A Case Of Neisseria Meningitidis Bacteremia In The First Trimester, Tiffany Pittman, Madison Morgan, Monica Drummond, Allison Tresner

Research Day

Introduction:

Meningococcal sepsis caused by Neisseria meningitidis is a rare but life-threatening infection, especially in pregnant women, where the risk of rapid deterioration can occur. The diagnosis of sepsis due to N. meningitidis in early pregnancy is particularly challenging due to limited treatment options that are safe for both mother and fetus. This case highlights the clinical course, diagnosis, and management of Neisseria meningitidis bacteremia in an 8-week pregnant woman, providing valuable insights for clinicians treating systemic infections in pregnancy.

Case Presentation:

A 29-year-old female, gravida 4 para 2012, at 8 weeks and 6 days gestation with no other contributory …

Bridging Healthcare Disparities In Native American Communities: The Role Of Telemedicine In Lung Cancer Screening And Ophthalmic Care., Maryam Ali, Debra Dougher

Research Day

Introduction

Native American populations experience significant healthcare disparities, particularly in lung cancer screening and ophthalmic care. Limited access to specialized medical services, geographic isolation, and socioeconomic barriers contribute to lower screening rates and higher disease burdens. Telemedicine offers a potential solution by bridging gaps in healthcare access and improving early detection and treatment. This study examines the effectiveness of telemedicine interventions in addressing these disparities.

Methods

A systematic literature review was conducted using PubMed, MEDLINE, Google Scholar, and Indian Health Service publications. Keywords included "Native American health disparities," "lung cancer screening," "ophthalmic care," and "telemedicine." Inclusion criteria focused on studies …

How To Qualify For The Political Contributions Credit Sec., John H. Wilguess

Tax Adviser

No abstract provided.

Contributors, Diamond Line Editors

Diamond Line Undergraduate Literary Magazine

No abstract provided.

Diamond Line - Spring 2025, Diamond Line Editors

Diamond Line Undergraduate Literary Magazine

No abstract provided.

The Role Of Regional Integration Organizations On Energy Transition And Sustainable Development In Africa, Neba Ridley Ngwa

Journal of African Policy Studies

The Paris Agreement represents a pivotal milestone in multilateral efforts to combat climate change and facilitate energy transition globally. As a comprehensive international legal framework, it outlines commitments for nations to reduce greenhouse gas emissions and enhance resilience to climate impacts. This research examines the key role of regional and sub-regional integration organizations in facilitating energy transition and promoting sustainable development across Africa. As the continent grapples with the dual challenges of energy crisis and climate change, the African Union and its specialised agencies have emerged as key players in enhancing energy cooperation among member states. Though previous scholars have …

Social Movements And Democratization In Nigeria Since 1999: The Search For Good Governance And Justice, Kwame Adum-Kyeremeh, Danladi Abah

Journal of African Policy Studies

What factors account for the surge in social movements in Nigeria and what are the implications for democratization? Who have been the actors and what internal and external dynamics are reconfiguring the materiality of social movements? How is the state responding to the dramatic fluidity and frequency in movements? And what strategies have civil societies used to harness the potentials in social movements for sustainable democratization? Through a political economy approach, oral interviews with NGO leaders, leaders of human rights and pro-democracy activists, interviews with some citizens, and use of journals, newspapers, magazines and reports, this study interrogates and documents …

Les Archives Au Cameroun Dans Les Politiques Publiques De Développement: Des Plans Quinquennaux A La Stratégie Nationale De Développement Snd 2020–2030, Esther Olembe

Journal of African Policy Studies

Cet article examine la place des archives dans le contenu des documents de politiques publiques de développements au Cameroun, depuis les plans quinquennaux d’aprèsindépendance jusqu’à la Stratégie Nationale de Développement 2020–2030 (SND2020–2030). Après l’accession aux indépendances, les pays africains ont cherché à formuler des politiques endogènes de développement, souvent sous l’influence des modèles de coopérations internationales. Le rôle des archives dans ces processus de développement est paradoxalement resté relativement marginal, bien que crucial pour la continuité et la transparence des actions publiques, comme le démontre la revue de la littérature étudiée. L’article met en lumière la difficile intégration des systèmes …

Leading Schools In The Midst Of Covid-19: Experiences Of Basic School Leaders Of The Komenda Edina Eguafo Abrem District Of The Central Region Of Ghana, Corinne Brion

Journal of African Policy Studies

This qualitative study uses a phenomenological approach to understand the experiences of thirteen Ghanaian head-teachers in suburban and rural areas of the Komenda Edina Eguafo Abrem district during the COVID-19 pandemic. Our findings revealed that these leaders faced numerous challenges related to pivoting to remote learning for the first time combined with the lack of access to technology. Other challenges pertained to the absence of infrastructure and resources such as books. Despite these challenges, these Ghanaian head-teachers were able to adapt to the crisis and alter their leadership style to educate the children they served. Currently, there is a limited …

Archives In Cameroon In Public Development Policies: From Five-Year Plans To The National Development Strategy 2020–2030, Esther Olembe

Journal of African Policy Studies

This article examines the role of archives in Cameroon’s public development policies, from post-independence five-year plans to the National Development Strategy 2020–2030 (SND2020–2030). After gaining independence, African countries sought to formulate endogenous development policies, often influenced by international cooperation models. However, archives have paradoxically remained relatively marginal in these development processes, despite being crucial for continuity and transparency in public actions, as demonstrated in the reviewed literature. The article highlights the challenges of integrating archive management systems into development strategies, despite being essential for the planning, management, and evaluation of public policies. It also analyzes current archiving policies and proposes …

Women And Men In The Media, Margaret Gallagher

Communication Research Trends

Since the time of Adam and eve no theme has held the attention of storytellers and their audiences more consistently than that of sexuality and the relationship between the sexes. It is multifaceted, ever-changing, and so deeply involves everyone emotionally that few other subjects present such a challenge to sociological analysis. All would have to admit, however, that the past century has seen unprecedented changes in the role and status of women in relation to men. The mass media have played their own part in this evolution, creating images which have helped to delineate and define its shifting currents.

This …