Digital Commons Network^™

Blood Bacterial Dna Signatures In A Prospective Cohort Of Patients With Masld Cirrhosis, Suet-Ying Kwan, Lillian I Dolapchiev, Caren I Sanchez, Tiffany L Calderone, Jessica I Sanchez, Megha B Bhongade, Ahmed El Sabagh, Darrel W Cleere, Nakul Gupta, Prasun K Jalal, David W Victor, Laura Beretta

Faculty, Staff and Student Publications

Background: Predictive biomarkers are needed to identify individuals with metabolic dysfunction-associated steatotic liver disease (MASLD), at high risk for HCC. Our study aimed to determine whether the detection of circulating bacterial DNA could be associated with HCC development in MASLD patients with liver cirrhosis.

Methods: We developed a multicenter prospective cohort of patients with cirrhosis undergoing surveillance for HCC by contrast-enhanced magnetic resonance imaging. In a nested cohort study, we performed 16S rRNA sequencing of cell-free DNA extracted from 343 longitudinal plasma samples collected from 151 MASLD patients with cirrhosis. Among the 151 patients, 25 developed HCC during follow-up.

Results: …

Technical Development And In Silico Implementation Of Syntheticmr In Head And Neck Adaptive Radiation Therapy: A Prospective R-Ideal Stage 0/1 Technology Development Report, Lucas Mccullum, Samuel L Mulder, Natalie A West, Robert Aghoghovbia, Alaa Mohamed Shawky Ali, Hayden Scott, Travis C Salzillo, Yao Ding, Alex Dresner, Ergys Subashi, Dan Ma, R Jason Stafford, Ken-Pin Hwang, Clifton D Fuller

Faculty, Staff and Student Publications

Background: SyntheticMR has the capability of generating quantitative relaxometry maps and synthetic contrast-weighted MRI images in rapid acquisition times. Recently, it has gained attention in the diagnostic community, however, no studies have investigated its feasibility on the MR-Simulation or MR-Linac systems, especially as part of the head and neck adaptive radiation oncology workflow.

Purpose: Demonstrating its feasibility will facilitate rapid quantitative biomarker extraction, which can be leveraged to guide adaptive radiation therapy decision making.

Methods: Two phantoms, two healthy volunteers, and one patient were scanned using SyntheticMR on the MR-Simulation and MR-Linac devices with scan times between 4 to 6 …

Impacts Of Radiation On Metabolism And Vascular Cell Senescence, Junichi Abe, Khanh Chau, Anahita Mojiri, Guangyu Wang, Masayoshi Oikawa, Venkata S K Samanthapudi, Abigail M Osborn, Keila C Ostos-Mendoza, Karla N Mariscal-Reyes, Tammay Mathur, Abhishek Jain, Joerg Herrmann, Syed Wamique Yusuf, Sunil Krishnan, Anita Deswal, Steven H Lin, Sivareddy Kotla, John P Cooke, Nhat-Tu Le

Faculty, Staff and Student Publications

Significance: This review investigates how radiation therapy (RT) increases the risk of delayed cardiovascular disease (CVD) in cancer survivors. Understanding the mechanisms underlying radiation-induced CVD is essential for developing targeted therapies to mitigate these effects and improve long-term outcomes for patients with cancer.

Recent Advances: Recent studies have primarily focused on metabolic alterations induced by irradiation in various cancer cell types. However, there remains a significant knowledge gap regarding the role of chronic metabolic alterations in normal cells, particularly vascular cells, in the progression of CVD after RT.

Critical Issues: This review centers on RT-induced metabolic alterations in vascular cells …

Supporting Administrative Time For Advanced Practitioners: A Comprehensive Approach, Merdith Beaton, Andrea Edwards, Wendy Vogel, Haleigh Mistry, Lisa Kottschade, Sara Toth, David Johnson, Heather Koniarczyk

Faculty, Staff and Student Publications

Advanced practitioners (APs), including nurse practitioners (NPs), physician assistants (PAs), clinical nurse specialists, and pharmacists, are pivotal in health care. Despite their critical role, record numbers of APs are leaving the profession, primarily due to poor work-life balance, which contributes to burnout and high turnover rates. This article explores the impact of administrative time on AP job satisfaction and retention, drawing from recent surveys and case studies. Findings indicate that dedicated administrative time significantly enhances job satisfaction and reduces burnout, with data showing that APs with administrative time are less likely to leave their roles. The Advanced Practitioner Society for …

Tumour And Microenvironment Crosstalk In Nsclc Progression And Response To Therapy, Zahraa Rahal, Roy El Darzi, Seyed Javad Moghaddam, Tina Cascone, Humam Kadara

Faculty, Staff and Student Publications

The treatment landscape of non-small-cell lung cancer (NSCLC) is evolving rapidly, driven by advances in the development of targeted agents and immunotherapies. Despite this progress, some patients have suboptimal responses to treatment, highlighting the need for new therapeutic strategies. In the past decade, the important role of the tumour microenvironment (TME) in NSCLC progression, metastatic dissemination and response to treatment has become increasingly evident. Understanding the complexity of the TME and its interactions with NSCLC can propel efforts to improve current treatment modalities, overcome resistance and develop new treatments, which will ultimately improve the outcomes of patients. In this Review, …

The Sports-Betting Market: A Road To Sports Betting As Viable Investing, Tyler Gottlieb

Vanderbilt Journal of Entertainment & Technology Law

Since its legalization, sports betting has experienced rapid growth, both in terms of economic output and expansion into more states. The current system of sports betting in the United States requires individuals to place bets using a sportsbook. The sportsbook sets the lines on every bet. If an individual wins their bet, the sportsbook pays them money according to the listed odds. If an individual loses their bet, the sportsbook keeps the amount staked. Sportsbooks set lines in a way to ensure that on average, they make money on every bet. This system has been widely accepted, often based on …

Wnt-Directed Cxcl12-Expressing Apical Papilla Progenitor Cells Drive Tooth Root Formation, Mizuki Nagata, Gaurav T Gadhvi, Taishi Komori, Yuki Arai, Hiroaki Manabe, Angel Ka Yan Chu, Ramandeep Kaur, Meer Ali, Yuntao Yang, Chiaki Tsutsumi-Arai, Yuta Nakai, Yuki Matsushita, Nicha Tokavanich, W Jim Zheng, Joshua D Welch, Noriaki Ono, Wanida Ono

Faculty, Staff and Student Publications

The tooth root is a critical component of the tooth anchored to surrounding alveolar bones. Tooth root formation is driven by cells in the apical papilla (AP) that generate new dentin-forming odontoblasts at the root-forming front. Mesenchymal stem cells have been isolated from AP for regenerative use; however, how AP cells physiologically coordinate tooth root formation remains undefined. We find that CXCL12+ cells emerge in AP under hypoxic environments at the onset of tooth root formation. Using Cxcl12-creER-based cell-lineage analysis, we further find that CXCL12+ AP cells contribute not only to odontoblasts but also to cementum-forming cementoblasts of the elongating …

Assessing Health And Academic Disparities In The Deep South: The Enduring Impact Of Segregation And Redlining In Georgia, Bridget Hamilton

Theses and Dissertations

Background: Within the American South, marginalized Black populations continue to suffer from health disparities. A key resource that could aid in the prevention of health disparities such as teen pregnancy is the school nurse. School nurses are well positioned to assist in the development of independent health maintenance among student populations. However, school nurses remain understaffed and underfunded throughout most of the United States, which limits their effectiveness. It is possible that within southern states there are inequities in how school resources are allocated that have ties to segregation and redlining practices that systemically marginalized Black populations throughout the 1900s. …

The Impact Of Consumer Complaints On Corporate Digital Transformation, Yingchao Lu, Hailing Chang, Yadan Zhou

Research Collection Lee Kong Chian School Of Business

This paper examines the impact of consumer complaints on corporate digital transformation and its underlying mechanisms. Using quarterly data from China's Shanghai and Shenzhen A-share listed companies from 2018 to 2023, the empirical results show that an increase in consumer complaints significantly hinders corporate digital transformation. Mechanism analysis reveals that consumer complaints raise legal risks and non-productive costs for firms, leading them to allocate more resources toward short-term crisis management rather than long-term digital development. Heterogeneity analysis indicates that this inhibitory effect is more pronounced in firms with weaker cybersecurity governance, firms whose executives lack a digital background, and firms …

Chronic Illness Education 2025: Improving Outcomes Of Hiv In Marginalized Populations, Aidan Bailey, Alexis Bowles, Ammar Chauhdri, Biola Makinde-Odusola, Dea Kanani, Keshav Sharma, Vasanth Palanisamy, Waffa Bakheet

Patient Education Projects

No abstract provided.

Chronic Illness Education 2025: Managing Hiv In Youth: A Case-Based Application Of The Expanded Chronic Care Model, Adam Kabbani, Ali Nasser, Emi Ueda-Martinez, Kristina Rizo, Mason Gardiner, Matthew Manson, Rachel Chee, Sydni Rosenfeld

Patient Education Projects

No abstract provided.

Chronic Illness Education 2025: Empowering Families With Resources To Combat Childhood Obesity, Abisola Fasakin, Alqasim Elnaggar, David Abdelnour, Mujeebah Kamal-Muili, Prit Patel, Ryan Palazzolo, Sydney Huston

Patient Education Projects

No abstract provided.

Chronic Illness Education 2025: Pediatric Depression And Anxiety: Hope Through Healthcare, Andreas Mozny, Arjan Goenaga Castillo, Audrey Millar, Ebony Williams, Griffin Lotze, Haytham Al-Qasmi, Kamontip Jongnarangsin, Tricia Jain

Patient Education Projects

No abstract provided.

Chronic Illness Education 2025: Education And Resources To Improve Pediatric Type I Diabetes Mellitus Care Within Schools And Child Care Services, Alexander Seidel, Alexandra Thomas, Christine Larrea, Daven Sarikonda, Jack Gurwin, Maria Karla Bermudez Pineiro, Matthew Mello, Sana Soman

Patient Education Projects

No abstract provided.

A Quantitative Examination Of The Sexual Health Of Aging Black Men In Rural South Africa, Esihle Lupindo

Dissertations and Doctoral Documents, University of Nebraska-Lincoln, 2023–

This dissertation uses survey data primarily from Wave 1 of the Health and Aging in Africa: Longitudinal Study of In-depth Community in South Africa (HAALSI) which was collected in 2015 to study the sexual health of Black men in rural Mpumalanga, South Africa. Broadly speaking, I examine aging men’s sexual health as it related to HIV, well-being, loneliness, social networks and disclosure. The definition that I use for sexual health was coined by MacPhail and Campbell (2001) who define it as “not only sexual practices but also what people know and believe about sex, particularly what they think is natural, …

Misinformation Regulations: Early Evidence On Corporate Social Media Strategy, Richard M. Crowley, Yun Lou, Samuel T. Tan, Liandong Zhang

Research Collection School Of Accountancy

Against the backdrop of an increasing threat of misinformation on social media, several countries have enacted regulations to curb the spread of misinformation. This study examines how corporate social media strategy responds to misinformation regulations. Using a large cross-country dataset of corporate tweets and a stacked regression analysis, we show that misinformation regulations lead to less corporate social media disclosure. This result suggests that by deterring misinformation, these regulations reduce firms’ need to use social media to counteract its adverse effects. Additional analyses show that the effect is more pronounced among countries with higher social media usage and countries with …

Efforts Of Public 2-Year Higher Education Institution Leadership Reducing Nonexempt Student Affairs Employees’ Intention To Quit, Christopher M. Viser

Electronic Theses and Dissertations

This narrative qualitative study examined the influence of leadership support and workplace factors on the intentions of nonexempt student affairs employees to leave a public 2-year higher education institution (HEI) in Texas. The study addressed the issue of workplace factors contributing to these employees’ developing intentions to quit their jobs. The research focused on identifying the workplace factors that most significantly influenced nonexempt student affairs employees and explored how leadership support influenced employee experiences. The study used narrative inquiry as its methodology to gather employee narratives through semistructured interviews conducted via Zoom, a communication platform. Nine participants were selected for …

Expanding Equity And Innovation In Pharmaceutical Law And Drug Development: Paying Clinical Trial Participants For Their Data, Steve Calandrillo, Bernadette Tosti, Jefferson Smith, Jamison Koeman

Articles

Bringing a drug to market is exceedingly expensive and exposes pharmaceutical manufacturers to significant legal risk. But when companies are successful, their profits make the PowerBall jackpot look like petty cash. Staggering rewards measure in the billions or millions for the firms, CEOs, pharmacies, drug benefit managers, data brokers, and many more actors in the pharmaceutical-to-patient pipeline. The only individuals who don’t get paid handsomely are the clinical trial participants, whose voluntary participation and data helped make those successes possible. It is long past time that we reform the legal and regulatory roadblocks to paying clinical trial participants in the …

Engage & Empower: Foundations Of Social Work Practice, Elhanan Marvit

Open Touro Created

2025

Engage & Empower: Foundations of Social Work Practice is an open educational resource for social work students in “foundations of social work practice” courses. It begins by explaining Open Educational Resources and their benefits. Students then explore social work fundamentals, including the diverse roles of social workers.

With this foundation, students engage with the NASW Code of Ethics’ key terms, and principles. This ethical grounding prepares them for the “growth work” needed to develop cultural competence and cross-cultural awareness. They then learn to apply various Generalist Practice skills across different-sized systems to empower client populations.

Next, the book explores …

Methods For Meaningful Connection: Supporting Teacher-Child Relationships In Early Care And Education, Sheila Smith, Maribel Granja, Cristina Medellin, Mark Nagasawa

Straus Institute for Thriving Children & Families

This report discusses a combined professional development/exploratory research project focused on how to support relationships between early childhood educators and children. The project piloted the Teacher Reflection Tool (TRT), a very brief reflection tool, paired with a community of practice approach with 19 early childhood educators across 10 classrooms. Among the lessons learned were that the participants:

• Viewed positive relationships with children as family-like and individualized
• Observed that their relationships with parents influenced relationships with children
• Found that the TRT helped them to notice and reflect on their interactions with children in new ways

Among the recommendations that emerged were: …

I Belong Here And Am Thriving: Understanding Full-Time Graduate Student Well-Being And Belonging In An Msw Program, Lana Hart Elkins

Theses and Dissertations

Graduate-level social work students face high levels of stress that can impact their academic success and well-being. According to a national college health assessment, fulltime Master of Social Work (MSW) students at a southeastern university report significantly more academic, career-related, and financial stress than peers in other graduate programs. This study addressed the need to better understand full-time MSW student experiences and identify ways the program can mitigate stress, promote wellbeing, and foster a sense of belonging. Using a two-phase qualitative action research design, the study first analyzed responses to 12 open-ended questions from four student feedback surveys. These findings …

Database Development For Reliable Small Object Detection In Maritime Environments, Jacob Matthew Whisenant

Theses and Dissertations

Achieving high reliability in small object detection is critical for advancing maritime and littoral intelligent navigation operations. Computer vision provides an undetectable form of perception that can be easily integrated into existing camera systems, offering a low-profile yet powerful solution for navigation and situational awareness in water-based environments. While deep learning techniques have significantly advanced the field of computer vision, the detection of small objects remains a persistent challenge. Limited pixel representation, the scarcity of large-scale small object datasets, and the reduced detail and indistinct features of small objects complicate detection efforts, especially in complex environments. These factors collectively hinder …

Improving Professional Learning Communities (Plcs) For Singletons, Stephanie Harbulak-Barron

Theses and Dissertations

Participation in professional learning is generally recognized as a required component of the teaching profession. One type of professional learning is professional learning communities (PLCs). However, there are challenges to implementing successful PLCs that result in relevant professional learning. One challenge is non-standard PLC groupings that contain singletons, especially when those PLC groups are primarily all singletons. This action research study examined educators’ and administrators’ expectations of and experiences with PLCs in a special education cooperative in the Midwest. The goal of the mixed methods research design was to gather enough information from participants to facilitate the creation of an …

Aggressive, Adaptive, And Underestimated: From Allergy To Arboviruses, The Rise Of The Lone Star Tick, Emily Ellen Owens Pickle

Theses and Dissertations

Once considered a nuisance with little medical importance, the lone star tick (Amblyomma americanum, Acari:Ixodidae) has emerged as a formidable vector driving a new era of public health threats across the United States of America. This dissertation traces the rise of the lone star tick from obscurity to infamy, exploring its expanding geographic range, unique immunologic impacts on humans, and role in the transmission of emerging tickborne viruses. Through a series of integrated studies, this work characterizes the epidemiology, immunology, and ecological context of tick-borne diseases in the southeastern U.S., with a particular focus on α-Gal syndrome (AGS), …

The Impact Of Adverse Childhood Experiences And Living With Hiv On Cardiovascular Health And Cardiometabolic Disorders In An African Population: An Analysis Of The Indepth Community In Rural South Africa, Samuel Gavi

Theses and Dissertations

Background: Adverse Childhood Experiences (ACEs) have been shown to be associated with cardiometabolic disorders (CMDs) and poor CVH; however, in Africa, this has not been well studied. Cardiovascular health (CVH) is an important measure of risk for cardiovascular diseases (CVD) developed by the American Heart Association (AHA). With the increasing prevalence of CVD in Africa, CVH is a potential upstream prevention approach. Africa also has the highest prevalence of HIV, and an increasing prevalence of comorbidities associated with it. Various mechanisms have been investigated to explain the relationship between CVD and chronic HIV infection. This study explores the potential relationship …

Examining Coping, Individual Resilience, And Family Resilience As Strengths-Based Factors For Lgbtq+ Individuals, Elizabeth Moriarty Combs

Theses and Dissertations

Lesbian, Gay, Bisexual, Transgender, Queer/Questioning, and More (LGBTQ+) individuals are part of a diverse and complex community that has unique considerations regarding physical and mental health. While there is ongoing health equity research regarding LGBTQ+ individuals, the focus is often on health disparities. A strengths-based approach to helping LGBTQ+ individuals through research and other avenues may be beneficial. This multi-manuscript dissertation includes two studies that explored the current literature on strengths-based factors such as coping, individual resilience, and family resilience within LGBTQ+ individuals, as well as determined the feasibility of utilizing these factors to assist LGBTQ+ individuals with health and …

An Investigation Of Preservice And Novice Elementary Education Graduate Students’ Self-Efficacy Toward Teaching Engineering Design, Victoria Harkins Cameron

Theses and Dissertations

This mixed-methods action research study examined how an experiential learning–based pedagogical approach influenced the development of teaching engineering self-efficacy in preservice and novice elementary education graduate students. Grounded in Bandura’s self-efficacy theory and Kolb’s experiential learning cycle, the study examined the impact of mastery experiences, vicarious experiences, verbal persuasion, and affective states on shaping participants’ instructional self-efficacy. Data were collected using the Teaching Engineering Self-Efficacy Scale (TESS), written reflections, and a focus group. Engineering pedagogical content knowledge was the only TESS construct to show statistically significant gains, while qualitative findings indicated broader growth in self-efficacy and emotional readiness. The study’s …

How Do People Discern Authenticity From Emotional Expressions, Sewon Oh

Theses and Dissertations

Emotional authenticity is a crucial element in the development and progression of social relationships. However, limited research has comprehensively examined how emotional authenticity perception is shaped by different communication channels, visual attention, and individual differences. This thesis aimed to investigate the emotional authenticity perception from multiple perspectives, including the feasibility of authenticity manipulation, the influence of multimodal cues, and visual attention allocation in assessing authenticity from facial expressions. Findings demonstrated that authenticity could be successfully manipulated by both professional and non-professional actors. Participants differentiated both authenticity and emotion most accurately in audiovisual expressions. The audio channel played an important role …

Action Research To Explore The Use Of Augmented Reality To Support High School Students In Understanding And Creating Art Work In A Drawing Course, Alicia Joanne Cobler

Theses and Dissertations

High school students in Drawing 1 at a high school in South Carolina struggle to understand meaning or make personal connections to their own artwork. The purpose of this action research was to evaluate the implementation of immersive reality technology, specifically augmented reality (AR), in art for high school Drawing 1 students to help them understand meaning in art and create their own meaningful artwork. Creating personally meaningful symbolic works of art is one of the first Visual Art National Core Standards (National Core Visual Art Standards, 2014). Creating meaning in artwork allows students to understand society, provide an opportunity …

Contemporary Anaylsis Of Black Male Experience Through Photovoice: A Second-Year Exploration, Ashley Dillahunt Dantzler

Theses and Dissertations

This dissertation investigates the second-year experiences of successful Black males at predominantly White institutions (PWIs), focusing on the University of South Carolina. While the second-year experience has gained attention in higher education research, specific insights into the challenges and successes faced by African American male students remain limited. This study highlights the critical issues surrounding sophomore retention, emphasizing that while universities often concentrate on first and final-year experiences, the second year is pivotal for academic success and continuation. Through qualitative methods, the research captures the narratives of ten participants, revealing common themes related to belonging, cultural understanding, and the impact …