Digital Commons Network^™

Baseline Characteristics Of Newly Registered Diabetic Patients In Primary Care Settings In Oman, Fathiya Al-Shariqi, Shaima Al-Mazoori, Zaher Al-Kharusi, Mohammed Al-Hinai, Samira Al-Maimani

Sultan Qaboos University Medical Journal

Objectives: This study aimed to identify the baseline demographic characteristics, clinical profile and cardiovascular risk factors of newly registered diabetic patients in Muscat Governorate, Oman, in 2022. Methods: This cross-sectional study included newly registered diabetic patients attending all primary care centres in Muscat Governorate in 2022. Data regarding sociodemographic characteristics and clinical and laboratory parameters were collected from the national diabetic registry and Al-Shifa health information system. Results: A total of 1,309 patients were included and their data analysed, of which 51% were male and the mean age was 53.89 ± 12.47 years. Approximately 50% of the participants were obese …

Everyday Life In The U.S.: An Intersectional Approach To A North Korean Refugee Woman’S Identities, And Experiences, Lyounghee Kim

Communication ETDs

This dissertation examines everyday experiences of a North Korean refugee woman in the U.S., centering her narratives as sites of critique, resistance, and meaning-making. Grounded in Critical Refugee Studies, Asian American Studies, and Critical Intercultural Communication and framed by intersectionality, it explores how interlocking structures of power shape and are shaped by her life. Rather than focusing solely on trauma or assimilation, this study highlights her digital storytelling, faith, and mutual aid practices as acts of survival, dignity, and moral agency. Using a qualitative, narrative inquiry approach grounded in critical reflexivity, it thematically analyzes her stories to reveal how she …

Wildlife Science Education For Grades 3–12, Natalie J. Carroll, Theodore Leuenberger, Katherine Leuenberger

Purdue University Press Books

Wildlife Science Education for Grades 3–12 guides and encourages youth to learn about the wildlife around them. The first section introduces the basic wildlife groups to youth in upper elementary school using hands-on and other activity-based learning techniques. Young learners will understand the similarities and differences between mammals, birds, fish, and herptiles. The activities for middle schoolers expand the study to interactions within and between them. The lessons for high school students are based on topics of importance to homeowners, residents of a watershed, food and fiber producers (farmers), mayors, teachers, and policy makers. This section delves deeper into the …

The Influence Of Family Literacy Playgroups On Early Childhood Development And Parent Efficacy In Hispanic Families: A Qualitative Phenomenological Case Study, Karen R. Loper

Graduate Theses, Dissertations, and Capstones

This qualitative phenomenological case study is focused on the engagement of Hispanic children between 18 and 36 months of age and their parents in a family literacy program. Participation in a family literacy program was associated with changes in the cognitive, social, and emotional development of children, as well as the self-efficacy of their parents in parenting skills. Grounded in the social theories of Vygotsky, Bandura, and Bronfenbrenner, this study relates the importance of language acquisition, literacy skills, and self-efficacy to a community setting where conversation is encouraged and reading engagement is modeled. The Hispanic population is underrepresented in the …

Correction: Bid-Induced Release Of Aif/Endog From Mitochondria Causes Apoptosis Of Macrophages During Infection With Leptospira Interrogans (Frontiers In Cellular And Infection Microbiology, (2017), 7, (471), 10.3389/Fcimb.2017.00471), Wei-Lin Hu, Hai-Yan Dong, Yang Li, David M. Ojcius, Shi-Jun Li, Jie Yan

Pacific Faculty Work

In the published article, there was an error in Figure 1E as published. The representative flow dot plots were misplaced. The corrected Figure 1 appears below. Apoptosis, pathological changes, and MMP decrease in leptospire-infected macrophages. (A) Apoptosis of macrophages infected with L. interrogans strain Lai at the optimal apoptosis-causing time for different MOIs. J774A.1 and THP-1 cells were infected with leptospires at 4 h. Bars show the mean ± SD of three independent experiments. Five thousand cells were analyzed in each specimen. *p < 0.05 vs. apoptotic ratios in leptospire-infected macrophages with an MOI of 10, 50, 100, or 500. (B) Apoptosis of macrophages infected with L. interrogans strain Lai at the optimal apoptosis-causing MOI for different times. J774A.1 and THP-1 cells were infected at an MOI of 100. Bars show the mean ± SD of three independent experiments. Five thousand cells were analyzed in each specimen. *p < 0.05 vs. apoptotic ratios in each macrophage type before infection. (C) The representative pathological changes in the nucleus and mitochondria in macrophages infected with L. interrogans strain Lai (MOI 100) for 4 h. a: healthly cells showed normal cellular morphology, b: chromatin margination in leptospire-infected macrophages crescent, c: mitochondrial shape in healthly macrophages, d: disappearance of mitochondrial cristae in leptospire-infected macrophages. (D) The representative MMP changes in macrophages during infection with L. interrogans strain Lai for the indicated times determined by fluorescence microscopy. The red cells have a high MMP while the green cells have a low MMP. (E) The representative MMP changes in macrophages during infection with L. interrogans strain Lai for the indicated times determined by flow cytometry. The FL2 channel indicates high MMP (red) while the FL1 channel shows low MMP (green). (F) Statistical summary of MMP changes by flow cytometry in leptospire-infected macrophages. Statistical data from experiments such as shown in (E). Bars show the mean ± SD of three independent experiments. The values at “0” h show the MMP values before infection. Five thousand cells were analyzed in each specimen. *p < 0.05 vs. MMP value of the macrophages before infection. (G) CSA blockage of the apoptosis in macrophages infected with L. interrogans strain Lai. Bars show the mean ± SD of three independent experiments. Five thousand cells were analyzed in each specimen. *p < 0.05 vs. apoptotic ratios in each macrophage type unpretreated with CSA infected with the spirochetes. The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated.

The Call Of Cucurrucucú, Rachel Olivia Blair

Dissertations and Theses

This is a site of geologic excavation; where charged voices like porous monoliths and forked-tongue shapeshifters call out in fragmented polyphony. What lies broken or misshapen, what can be pieced back together.

What is purity when the body that is being inherited is drowning in murky waters.

Can Mere Possession Of A Consumer Product Boast Your Self-Efficacy? : A Cultural Perspective, Yixuan Gao

Lingnan Theses (MPhil & PhD)

Beggan (1992) introduced the mere ownership effect, suggesting that people evaluate owned objects more positively. Beggan argued that ownership fosters a psychological bond between people and their possessions, driven by self-enhancement motives (e.g., “I am good, thus my object must be good”). Yeung et al. (2017, 2020) extended the mere ownership effect, showing that ownership influences self-evaluations (e.g., I own a book so I am knowledgeable). Previous studies on the “person-based” mere ownership effect have primarily focused on East Asian participants. This thesis aims to compare cross-cultural differences, if any, in the “person-based” mere ownership effect (Study 1), and systematically …

Joint Disclosure Statement

Catholic Dioceses in Bankruptcy

No abstract provided.

Patient Information Needs During Ambulatory Medication Changes: A Qualitative Study, Elaine Giletta, Vanessa B. Hurley, Yushi Yang, Jessica L. Schwartz, Rabia Jalalzai, Nicole L. Mollenkopf, Raquel Mayne, Samantha I. Pitts

Journal of Patient-Centered Research and Reviews

Purpose: We performed interviews with patients and caregivers to explore whole-person, whole-regimen information needs at times of routine outpatient medication changes. We categorized information needs in this relatively unstudied context and identified which needs were commonly recognized as insufficiently met.

Methods: We explored the content of the semi-structured interviews, which involved nine patients and two caregivers of pediatric patients, all of whom experienced a recent medication change in the outpatient setting of a large urban academic healthcare system. We used inductive thematic analysis to organize information needs into categories to identify key information gaps.

Results: We identified five categories of …

Mechanisms And Intermediate Outcomes Of A Community Translation To Adapt A Whole Family-Inclusive Lifestyle Intervention: A Pilot Evaluation, Megan J. Moran, Kimberly Padilla, Abby Neiser, Nicole Clark, Virginia Jimenez, Natalia Sanchez, Talia Thompson, Ana M. Gutierrez-Colina, Jesse Owen, Chesleigh Keene, Matthew A. Haemer, Lauren B. Shomaker

Journal of Patient-Centered Research and Reviews

Purpose: Involving community members in the process of translating scientific evidence into health messaging and interventions can lead to improved health outcomes and more patient-centered healthcare. Community Translation (CT) is one methodology for fostering collaboration between researchers and community members, and it has been shown to result in locally relevant, acceptable solutions to health challenges. There has been very little research on the direct effects that participation may have on community members who become involved in CT. Understanding the mechanisms of CT and its outcomes on participating community members is essential to maximizing the potential of CT. To address this …

The Hazard Ratio Is Equivalent To An Odds Under The Assumption Of Proportional Hazards, David M. Thompson

Journal of Patient-Centered Research and Reviews

Clinicians routinely interpret statistical findings from medical research to inform patients of treatment benefits. Studies that use the hazard ratio present special challenges. Clinicians should not equate hazard ratios with risk ratios, ie, relative risks. However, clinicians can provide patients with a straightforward interpretation of the hazard ratio as an odds, as long as the ratio was calculated in a study in which the assumption of proportional hazards is justified. In such a case, the hazard ratio is equivalent to the odds that a person, who is randomly chosen from the group represented in the ratio’s numerator, experiences an event …

Emergency Managers Perceived Effectiveness Of Disaster Mitigation Plans And Training Focused On The Special Needs Population, Jessica Windsor

Walden Dissertations and Doctoral Studies

The special needs population faces increased vulnerability during disasters, yet disaster planning often overlooks their unique requirements. This study focuses on the experiences and perceptions of emergency managers in the Southeastern United States. The purpose of the study was to examine the extent to which emergency management plans recognize and address the needs of special populations and identify training gaps. The research questions aimed to uncover the factors that influence inclusive planning, training effectiveness, and resource allocation. Grounded in the Disaster Health Framework, the study utilized a qualitative research design involving surveys with 14 emergency managers, followed by thematic analysis …

Effective Strategies Adult Education Business Leaders Use To Attain Their Organization's Sustainability, Ryan J. Bagshaw

Walden Dissertations and Doctoral Studies

Leaders in nonprofit adult education frequently struggle with maintaining financial sustainability, a challenge that can compromise their operations and the positive influence they have on their communities. This issue is critical for education leaders and policymakers who rely on these institutions to support workforce development and foster economic growth. Grounded in the Baldrige framework, the purpose of this qualitative single-case study was to identify and explore the strategies employed by leaders of a Caribbean nonprofit adult education organization to enhance their organization’s sustainability. The participants were four leaders from an adult education facility in St. Lucia, the Caribbean. Data sources …

Driving Implementation Of Segregation Of Duties Processes, Marlin Earl Moyer

Walden Dissertations and Doctoral Studies

In the healthcare industry, safeguarding the confidentiality, integrity, and accessibility of IT systems is crucial. However, some organizations face difficulties in implementing effective segregation of duties (SoD) processes, which can lead to increased risks. This is a major concern for healthcare IT leaders and organizations, as inadequate SoD can compromise patient data security and disrupt operational efficiency. The purpose of this qualitative, pragmatic study was to explore the strategies used by senior IT leaders to implement SoD processes. The transformational leadership theory was used as the conceptual framework for the study. The participants included seven IT leaders at Northeastern U.S. …

Assessment Of Knowledge About Toxoplasmosis Among Nursing College Students, Zainab Hassan, Saba Adnan, Abdulameer Abdullah Al- Musawi

Iraqi National Journal of Medicine

Background: Toxoplasmosis is a parasitic disease caused by Toxoplasma gondii. Humans acquire toxoplasmosis by consuming infected meat containing cysts of T. gondii or through contact with cat feces. Toxoplasmosis is known to cause miscarriage, also referred to as spontaneous abortion or pregnancy loss, which pertains to an unviable intrauterine pregnancy occurring during the first trimester and is the most common type of miscarriage. Aim: The aim of this study is to assess the level of knowledge of nursing students about toxoplasmosis. Methods: A questionnaire was administered to 90 nursing students. The self-completed questionnaire consisted of 17 questions covering the parasite, …

Mothers’ Plan To Protect Their Children From Covid-19 And Other Viral Illnesses, Miami Kadhum Yossif, Rehab Abdulwehab Jaafer

Iraqi National Journal of Medicine

Background: Mothers play a critical role in safeguarding the health and well-being of their children—a vulnerable population—particularly during outbreaks of infectious diseases. Aim: This study investigated the strategies employed by mothers to protect their children from COVID-19 and other viral illnesses. Methods: A cross-sectional study was conducted at the outpatient pediatric clinics of Basra Maternity and Children Hospital and Almawani Teaching Hospital, 118 mothers were enrolled from diverse backgrounds. Data was collected through structured interviews and a standardized questionnaire designed to assess maternal practices, attitudes, and experiences concerning the protection of their children. The key areas explored included hygiene practices, …

Barriers To Diet And Exercise Among Patients With Type 2 Diabetes Mellitus In Basrah Hospitals, Jhood Abdul Samad Molan, Fatima K. Hassan, Miaad K. Khaddam, Zainab A.R. Antesh, Hudaa S. Karim

Iraqi National Journal of Medicine

Background: Type 2 diabetes mellitus (T2DM) is growing health concern globally, particularly in the Middle East. To encourage individuals to adopt a healthy lifestyle essential for managing diabetes, it is imperative to thoroughly understand the barriers, especially those that can be modified, encountered by patients following nutritional and exercise medical advice. Aim: The primary objective of this study was to investigate the barriers related to nutrition and exercise among patients with T2DM in hospitals located in Basrah. Methods: This cross-sectional study included 194 adults with history of T2DM who were visiting the outpatient departments of internal medicine in four selected …

Isolation Enhancement Based On Tm010 And Te30 Mode Characteristics In A Patch Antennas Using Genetic Algorithm Optimization For Ku-Band Applications, Muddineni Raveendra, U. Saravanakumar, P. Padmaloshani, P. Saam Prasanth Dheeraj, Anand Anbalagan, R. Sreelakshmy

Electrical and Computer Engineering Faculty Publications and Presentations

This paper proposes a novel technique to enhance isolation in rectangular patch antennas by leveraging the mode characteristics of TM010 and TE30 to achieve better than −40 dB between the transmitter and receiver with dual‐polarization features. The primary innovation of this work lies in achieving significant isolation enhancement solely by combining two resonant modes with orthogonal polarizations, without incorporating any additional design elements such as parasitic components or decoupling structures. To validate the isolation enhancement based on these mode characteristics, a pair of rectangular transmitter and receiver patch antennas was designed to operate in the frequency range from 14 to …

July 15, 2025 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Technology Roadmap Of Micro/Nanorobots, Xiaohui Ju, Chuanrui Chen, Cagatay M Oral, Semih Sevim, Ramin Golestanian, Mengmeng Sun, Negin Bouzari, Xiankun Lin, Mario Urso, Jong Seok Nam, Yujang Cho, Xia Peng, Fabian C Landers, Shihao Yang, Azin Adibi, Nahid Taz, Raphael Wittkowski, Daniel Ahmed, Wei Wang, Veronika Magdanz, Mariana Medina-Sánchez, Maria Guix, Naimat Bari, Bahareh Behkam, Raymond Kapral, Yaxin Huang, Jinyao Tang, Ben Wang, Konstantin Morozov, Alexander Leshansky, Sarmad Ahmad Abbasi, Hongsoo Choi, Subhadip Ghosh, Bárbara Borges Fernandes, Giuseppe Battaglia, Peer Fischer, Ambarish Ghosh, Beatriz Jurado Sánchez, Alberto Escarpa, Quentin Martinet, Jérémie Palacci, Eric Lauga, Jeffrey Moran, Miguel A Ramos-Docampo, Brigitte Städler, Ramón Santiago Herrera Restrepo, Gilad Yossifon, James D Nicholas, Jordi Ignés-Mullol, Josep Puigmartí-Luis, Yutong Liu, Lauren D Zarzar, C Wyatt Shields, Longqiu Li, Shanshan Li, Xing Ma, David H Gracias, Orlin Velev, Samuel Sánchez, Maria Jose Esplandiu, Juliane Simmchen, Antonio Lobosco, Sarthak Misra, Zhiguang Wu, Jinxing Li, Alexander Kuhn, Amir Nourhani, Tijana Maric, Ze Xiong, Amirreza Aghakhani, Yongfeng Mei, Yingfeng Tu, Fei Peng, Eric Diller, Mahmut Selman Sakar, Ayusman Sen, Junhui Law, Yu Sun, Abdon Pena-Francesch, Katherine Villa, Huaizhi Li, Donglei Emma Fan, Kang Liang, Tony Jun Huang, Xiang-Zhong Chen, Songsong Tang, Xueji Zhang, Jizhai Cui, Hong Wang, Wei Gao, Vineeth Kumar Bandari, Oliver G Schmidt, Xianghua Wu, Jianguo Guan, Metin Sitti, Bradley J Nelson, Salvador Pané, Li Zhang, Hamed Shahsavan, Qiang He, Il-Doo Kim, Joseph Wang, Martin Pumera

Faculty, Staff and Student Publications

Inspired by Richard Feynman’s 1959 lecture and the 1966 film Fantastic Voyage, the field of micro/nanorobots has evolved from science fiction to reality, with significant advancements in biomedical and environmental applications. Despite the rapid progress, the deployment of functional micro/nanorobots remains limited. This review of the technology roadmap identifies key challenges hindering their widespread use, focusing on propulsion mechanisms, fundamental theoretical aspects, collective behavior, material design, and embodied intelligence. We explore the current state of micro/nanorobot technology, with an emphasis on applications in biomedicine, environmental remediation, analytical sensing, and other industrial technological aspects. Additionally, we analyze issues related to …

Synergistic Activity Of Combined Flt3-Itd And Mdm2 Inhibition With Quizartinib And Milademetan In Flt3-Itd Mutant/Tp53 Wild-Type Acute Myeloid Leukemias, Weiguo Zhang, Li Li, Muharrem Muftuoglu, Mahesh Basyal, Noriko Togashi, Koichi Iwanaga, Fumie Tanzawa, Masashi Numata, Dale L Bixby, Harry P Erba, Nikolai Podoltsev, Gary J Schiller, Prasanna Kumar, Arnaud Lesegretain, Takeshi Isoyama, Takahiko Seki, Naval Daver, Michael Andreeff

Faculty, Staff and Student Publications

Purpose: Acute myeloid leukemia (AML) is characterized by frequent mutations in FMS-like tyrosine kinase 3 (FLT3), overexpression of murine double minute 2 (MDM2), and TP53 wild-type (WT). Monotherapies targeting FLT3 frequently result in the development of resistant disease. In this study, we investigated the antileukemic efficacy of co-targeting FLT3 and MDM2 with quizartinib and milademetan (Q/M) in FLT3 internal tandem duplication (FLT3-ITD) AML cell lines, xenograft and patient-derived xenograft (PDX) models, and a phase I clinical trial.

Experimental design: Preclinical studies used human and murine cell lines carrying FLT3-ITD and/or tyrosine kinase domain mutations, TP53 WT/knockdown, leukemia cell xenograft models, …

Medpix®: Database Of Medical Images, Teaching Cases, And Clinical Topics, Alex Henigman, Brandon Kennedy

Library Staff Publications

MedPix is a free, open-access, online database developed by the National Library of Medicine that houses a vast collection of over 59,000 medical images, 12,000 patient cases, and 9,000 clinical topics. Designed to support both teaching and self-directed learning, the platform serves a diverse audience including physicians, medical students, educators, and researchers. MedPix offers robust search capabilities as well as case-based learning tools that support Continuing Medical Education.

Integrating Artificial Intelligence And Machine Learning Technologies Into Common Operating Picture And Course Of Action Development, C. Anthony Pfaff, Christopher John Hickey

Books, Monographs & Collaborative Studies

C. Anthony Pfaff and Christopher John Hickey, Principal Investigators

©2025 C. Anthony Pfaff. All rights reserved.

Integrating Artificial Intelligence and Machine Learning Technologies into Common Operating Picture and Course of Action Development explores the potential of artificial intelligence (AI) and machine learning to revolutionize military planning processes by enhancing situational awareness and expediting course of action development within the Joint planning process. The study delves into technical, organizational, and resource considerations that are critical for AI integration. In addition, the study highlights the importance of clean, structured data in training AI systems, addresses challenges in data collection across varying formats …

Non-Invasive Telemonitoring In Heart Failure: A Systematic Review, Patrick A. Kwaah, Emmanuel Olumuyide, Kassem Farhat, Barbara Malaga-Espinoza, Ahmed Abdullah, Michael H. Beasley, Novi Y. Sari, Lily K. Stern, Julio A. Lamprea-Montealegre, Adrian Dasilva-Deabreu, Jiun-Ruey Hu

School of Medicine Publications

Background and Objectives: Heart failure (HF) represents a major public health challenge worldwide, with rising prevalence, high morbidity and mortality rates, and substantial healthcare costs. Non-invasive telemonitoring has emerged as a promising adjunct in HF management, yet its clinical effectiveness remains unclear. Materials and Methods: In this systematic review, we summarize randomized controlled trials (RCTs) between 2004 and 2024 examining the efficacy of non-invasive telemonitoring on mortality, readmission, and quality of life (QoL) in HF. In addition, we characterize the heterogeneity of features of different telemonitoring interventions. Results: In total, 32 RCTs were included, comprising 13,294 participants. While some individual …

Decline In Skills And Regression In Adolescents And Adults With Down Syndrome, Brian Chicoine

Advocate GME

Individuals with Down syndrome may experience a decline in skills for many reasons. A thorough evaluation is indicated to identify potential causes and optimize treatment. In this webinar, Brian Chicoine, MD, will discuss possible causes for decline in skills, including Down syndrome regression disorder, Alzheimer’s disease, and others. He will also describe potential treatments and strategies that can be used when supporting an individual with Down syndrome who is experiencing a decline in skills.

Exploring The Impact Of The Emergency Department Built Environment On Physician Workplace Stress: A Qualitative Study Utilizing High-Fidelity Virtual Reality, J Matthew Fields, Alan Price, Billie Faircloth, Eden Blas, Marah Sakkal, Sabrina Naumovski, Robert Ries, Callum Hamilton, Kit Elsworth, Morgan Hutchinson, Bon Ku, Christopher Connock, Jennifer Kahoud

Department of Emergency Medicine Faculty Papers

OBJECTIVES: Physician burnout in emergency medicine has serious consequences. An underrecognized stressor for physicians may be the emergency department (ED) environment itself. EDs can be noisy and chaotic, lack natural light, and have challenging layouts that create patient care and safety concerns. This study examines the relationship between the ED-built environment and physician workplace stress.

METHODS: A qualitative study of ED-attending physicians from a level I trauma center ED in Philadelphia was conducted. Participants underwent a semistructured interview followed by a walkthrough of a high-fidelity virtual reality (VR) simulation of the participant's ED. In the VR simulation, they rated the …

With Vim And Courage: Confederate Soldiers And The Politics Of War, Michelle N. Norello

LSU Master's Theses

The Confederate cause has captivated historians for many decades. At first glance, the Confederacy embodies a persistent effort to promote white supremacy, the planter class, and independence. While this assessment is accurate, individual Confederate soldiers possess diverse narratives that both challenge and support the labels assigned over the years. The political dimension of the Civil War opens new avenues for scholarly exploration concerning Confederate soldiers. But what insights might this offer regarding the nature of the Confederacy, civilian political engagement, and democracy? The answer to this question is complex and nonlinear. Previous research has acknowledged the numerous reasons why Confederate …

A Systems Engineering Approach To Improve Alarm Management And Nurse Mental Workload, Benjamin D. Elmore

LSU Doctoral Dissertations

Alarm fatigue has been a consistent problem nurses have experienced for decades. The effects of excessive nuisance alarms leads to adverse effects such as desensitization, missed alarms, frustration, and increased risk to patient safety. Other research has provided explanations on alarm fatigue causes and developed solutions for reducing nuisance alarms or minimizing effects, but few have examined the problem from a sociotechnical systems perspective. This study applied the Systems Engineering Initiative for Patient Safety (SEIPS) framework to define, design, and test an alarm management intervention compatible with a Progressive Care Unit (PCU)’s sociotechnical subsystems. The SEIPS application is unique from …

Serum Metabolomic Profiling Of Incident Type 2 Diabetes Mellitus In The Multi-Ethnic Study Of Atherosclerosis And Rotterdam Study, Xuanwei Jiang, Fang Zhu, Gonçalo Graça, Xihao Du, Jinjun Ran, Fariba Ahmadizar, Alexis C Wood, Yanqiu Zhou, Denise M Scholtens, Ali Farzaneh, M Arfan Ikram, Alan Kuang, Carel W Le Roux, Meghana D Gadgil, Marilyn C Cornelis, Kent D Taylor, Xiuqing Guo, Mohsen Ghanbari, Laura J Rasmussen-Torvik, Russell P Tracy, Alain G Bertoni, Jerome I Rotter, David M Herrington, Philip Greenland, Maryam Kavousi, Victor W Zhong

Children’s Nutrition Research Center Staff Publications

Objective: This study aimed to investigate serum metabolomic biomarkers associated with incident type 2 diabetes mellitus (T2DM) and evaluate their performance in improving T2DM risk prediction.

Methods: Untargeted proton nuclear magnetic resonance (1H NMR) spectroscopy-based metabolomics analyses were conducted in the Multi-Ethnic Study of Atherosclerosis (MESA; n = 3460; discovery cohort) and The Rotterdam Study (RS; n = 1556; replication cohort). Multivariable cause-specific hazards models were used to analyze the associations between 23 571 serum metabolomic spectral variables and incident T2DM. Replicated metabolites required an false discovery rate-adjusted P < .01 in MESA, P < .05 in RS, and consistent direction of association. Pathway and network analyses were conducted to elucidate biological mechanisms underlying T2DM development. The utility of the replicated metabolites in improving T2DM risk prediction was assessed based on the Framingham Diabetes Risk Score. A 2-sample Mendelian randomization was conducted to assess causal associations.

Results: Nineteen metabolites were significantly associated with incident T2DM. Pathway analyses …

Role Of Lipoprotein(A) In Atherosclerotic Cardiovascular Disease In South Asian Individuals, Darshan Patel, Marlys L Koschinsky, Anandita Agarwala, Pradeep Natarajan, Harpreet S Bhatia, Anurag Mehta, Jaideep Patel, Matthew Peters, Shreya Pandya, Usman Sagheer, Raman Puri, Salim S Virani, Dinesh K Kalra

Faculty, Staff and Students Publications

South Asian individuals (SA), representing approximately one quarter of the global population, experience a disproportionately high burden of cardiovascular disease. Some of this increased susceptibility is accounted for by traditional risk factors such as diabetes, hypertension, carbohydrate-rich diets, and rising rates of obesity and metabolic syndrome. However, other previously underappreciated risk factors may also play a crucial role. These include environmental pollution, genetic factors, and Lp(a) (lipoprotein(a)). Various epidemiological and genetic studies support the role of Lp(a) as a causal and independent risk factor for atherosclerotic cardiovascular disease. SA have a higher prevalence of elevated Lp(a) levels (25% have levels …