Digital Commons Network^™

Fibroblasts Are The Primary Contributors To A Disrupted Micro-Environment In End-Stage Pediatric Hypertrophic Cardiomyopathy, Hanna J Tadros, Diwakar Turaga, Yi Zhao, Chang-Ru Tsai, Iki A Adachi, Xiao Li, James F Martin

Faculty, Staff and Students Publications

Background: Hypertrophic cardiomyopathy (HCM) is a relatively rare but debilitating diagnosis in the pediatric population, and patients with end-stage HCM require heart transplantation. Here, we have examined the transcriptome in ventricular tissue from this patient group to identify cell states and underlying cellular processes unique to pediatric HCM.

Methods: We performed single-nucleus RNA sequencing (snRNA-seq) on explanted hearts at transplant in 3 pediatric patients with end-stage HCM and compared findings to pediatric control and adult HCM.

Results: We identified distinct underlying cellular processes in cardiomyocytes, fibroblasts, endothelial cells, and myeloid cells compared with controls. Pediatric HCM was enriched in cardiomyocytes …

Patient-Centered Communication Case: Threatened Miscarriage, Anita Rohra, Daniela Ortiz, Shagun Berry, Colleen Donovan, Nicole Novotny, Stephanie Cohen, Charles Lei, Alaa Aldalati, Stephanie Stapleton, David Fernandez

Faculty, Staff and Students Publications

Audience: This communication case is intended for EM residents of all levels.

Introduction: Patient-centered communication is a necessary skill in the practice of emergency medicine. This style of communication is crucial for promoting high-quality healthcare by prioritizing patient needs, perspectives, and values. This patient-centered communication case centers on miscarriage, a diagnosis where patient-centered communication is requisite. Approximately one in six or 17.1% of patients with a final diagnosis of miscarriage, also known as early pregnancy loss, present initially to the emergency department.1 Advising a patient of the diagnosis of miscarriage requires excellent communication skills including facile rapport building, empathy, nonverbal …

Managing Conflict Case: The Difficult Consultant, Amrita Vempati, Suzanne Bentley, Anita Rohra, Daniela Ortiz, David Fernandez, Shagun Berry, Colleen Donovan, Nicole Novotny, Stephanie Cohen, Stephanie Stapleton, Tiffany Moadel

Faculty, Staff and Students Publications

Audience: This communication case is intended for emergency medicine (EM) resident physicians and junior faculty preparing for the ABEM Certifying Exam.

Introduction: Conflict management is a common and significant challenge in the emergency department (ED), with potential negative impact on both physicians and patients. At the individual level, hospital-based conflicts can lead to emotional stress, impaired concentration, decreased trust among providers, and feelings of dehumanization.1 For patients, conflicts between physicians can compromise the quality of care and contribute to delays in treatment.1 In the ED, conflict often arises between emergency physicians (EPs) and various stakeholders, including patients, family members, nursing …

Where, How, And How Much? A Multicenter Cohort Study Of The Relationship Across Lupus Decision-Aid Modality, Place Of Administration, Interruption And Viewing Completeness, And Patient-Reported Outcomes, Jasvinder A Singh, Mark Beasley, Larry R Hearld

Faculty, Staff and Students Publications

Objective: We assessed whether shared decision-making (SDM) and patient acceptability, feasibility, and overall satisfaction with a computerized patient decision aid (PtDA) for patients with systemic lupus erythematosus (SLE) differs by PtDA setting, modality, and the viewing experience.

Methods: Patients with SLE were invited to view a self-administered computerized SLE PtDA during regular clinic visits at 15 rheumatology clinics in an implementation trial. Patients completed a survey that included SDM measures including the decision conflict scale (DCS), Preparation for Decision Making (PDM) scale, and CollaboRATE scale, and we measured perceived patient acceptability, feasibility, and satisfaction. Patients viewed the SLE PtDA in …

The Neonatal Gut Microbiome In Health And Disease, Geoffrey A Preidis

Faculty, Staff and Students Publications

No abstract provided.

Differential Microrna Profiling Of Blood L1cam And Bulk Extracellular Vesicles In Bipolar Disorder, Gabriel R Fries, Salahudeen Mirza, Jun Wang, Camila N C Lima, Wei Zhang, Marcela Carbajal Tamez, Giselli Scaini, Jair C Soares, Joao Quevedo

Faculty, Staff and Student Publications

Objective: This preliminary study aimed to identify microRNA (miRNA) signatures associated with bipolar disorder (BD) by profiling blood-derived extracellular vesicles (EVs) of both putative neuronal origin and from all sources.

Method: In two parallel studies of individuals with BD and controls (CON), we characterized miRNA expression profiles of blood EVs selected for L1CAM, a putative marker of neuronal origin (n = 20 BD/20 CON), as well as bulk EVs (n = 21 BD/20 CON). For each study, analyses identified miRNAs differentially expressed between groups, followed by functional interrogation and testing for associations with clinical features.

Results: Results of …

Promoting Professionalism In Medical Education: A Toolbox For Effective Feedback And Remediation, Matthew R Carroll, Gal Barak, Tracy Byrne, Huma Farid

Faculty, Staff and Students Publications

No abstract provided.

A Model For Developing Subspecialty Clinical Practice Guidelines: The Geriatric Emergency Department Guidelines 20, Satheesh Gunaga, Christopher R Carpenter, Maura Kennedy, Lauren T Southerland, Alexander X Lo, Sangil Lee, Kirby Swan, Fabrice Mowbray, Rachel M Skains, Teresita M Hogan, Martin F Casey, Kei Ouchi, Naomi R George, Kerstin De Wit, Cameron J Gettel, Katherine Selman, Luna C Ragsdale, Anita N Chary, James D Van Oppen, Glenn Arendts, Charles L Maddow, Katherine M Hunold, Katren R Tyler, Danya Khoujah, Ula Hwang, Shan Liu

Faculty, Staff and Students Publications

The original consensus-based Geriatric Emergency Department (GED) Guidelines, published in 2014, established a framework of core principles for delivering high-quality, age-appropriate emergency care for older adults. In response to significant advances in geriatric emergency medicine research and evolving clinical priorities, we developed the GED Guidelines 2.0 to ensure continued relevance, clinical utility, and evidence-based rigor. This concept paper describes the systematic and iterative process undertaken to update the guidelines, including the formation of multidisciplinary working groups and the application of the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) methodology. Unlike the original GED Guidelines, our approach prioritized methodological transparency, …

Ataxia-Telangiectasia Mutated Activation Mediates Transforming Growth Factor Beta Signaling In Acetaminophen-Induced Liver Injury In Mice, Matthew Mcmillin, Christopher S Chu, Elaina Williams, Juliet Venter, Kiersten Bell, Anca D Petrescu, Patrick Mireles, Sharon Demorrow

Faculty and Staff Publications

Acetaminophen (APAP) overdose is associated with increased transforming growth factor beta 1 (TGFβ1) signaling and elevated oxidative stress, which exacerbate DNA damage. TGFβ1 has been shown to regulate ataxia-telangiectasia mutated (ATM) signaling and DNA repair in other cell types. This study investigates the DNA damage response (DDR) during APAP-induced liver injury, focusing on ATM-mediated regulation of TGFβ1 signaling. APAP administration in vitro and in vivo resulted in DNA damage, increased ATM signaling, accumulation of γH2AX, and activation of phosphorylated ataxia telangiectasia mutated (pATM) and phosphorylated checkpoint kinase 2 (pChk2). Pretreatment with an ATM inhibitor, KU55933, attenuated APAP-induced hepatocyte damage and …

Decreasing Barriers To The Utilization Of Cryopreserved Sperm In Male Cancer Survivors: An Expert Review And Guide, Megan V Alexander, Hailie Ciomperlik, Anna Claire Reynolds, Allyson Nevins, Luwam Ghidei, Jordan Kassab, Kevin Campbell, John Sullivan, Michael D Jochum, Laura Detti, Terri L Woodard, Larry I Lipshultz, Laurie J Mckenzie

Faculty, Staff and Students Publications

Background: Sperm cryopreservation offers male cancer patients a critical opportunity to preserve fertility prior to gonadotoxic therapy, yet utilization of banked sperm remains modest, typically under 10%. A structured understanding of barriers across the cancer survivorship continuum is needed to support patients in utilization of cryopreserved sperm in alignment with their reproductive goals.

Materials and methods: This expert review synthesizes current evidence and clinical experience to explore the multifaceted barriers to cryopreserved sperm use and propose specific solutions. Key intervention timepoints are examined, including the post-treatment fertility return visit, long-term cryopreservation while remote from family building, readiness for family building, …

"I Wished I Could Have Said Bye": Exploring Youth Reactions To Formal Mentoring Relationship Endings, Thomas E. Keller, Martha J. Mccormack, Miriam Miranda-Diaz, Alison L. Drew, Renee Spencer

School of Social Work Faculty Publications and Presentations

Youth mentoring programs strive to create stable, supportive relationships between adult mentors and youth mentees to promote positive youth development. Although these formal relationships always reach a conclusion, little is known about how mentees experience the endings of their relationships. This study elicits the words and perspectives of mentees to investigate the emotional reactions provoked by mentoring relationship terminations. Participants were youth (n = 72) in a prospective study of mentoring relationship development who completed a survey following the official closure of their match. Asked how they felt about the match ending, mentees more often indicated negative rather than positive …

Auction Consensus Algorithm With Loss Mechanism For Decentralized Task Allocation, Jose Rodriguez, Wenjie Dong, Constantine Tarawneh, Qi Lu

Electrical and Computer Engineering Faculty Publications

This paper presents an Auction-Consensus Algorithm with a Loss Mechanism (ACALM), a decentralized task allocation method for multi-robot systems that enhances the existing Consensus-Based Auction Algorithm (CBAA) by incorporating a novel loss propagation mechanism. In contrast to purely greedy bidding strategies, it enables agents to dynamically update task priorities based on the accumulated loss from previously unsuccessful bids. This extended work reduces globally inefficient allocations caused by early suboptimal decisions. The proposed approach is evaluated through large-scale simulations in thousands of randomized scenarios and swarm sizes ranging from 5 to 120 robots. Compared to existing CBAA and GCAA algorithms, ACALM …

Making The Invisible Visible: Cultivating Contexts For Equitable Workloads, Andrea Carlile

Journal of the Association for Communication Administration

Women make up the majority of degree earners and most of those teaching at higher education institutions. Yet, women are not advancing to the highest ranks. How female faculty receive credit for their work may account for the discrepancy in women advancing to the highest ranks. This single-institution case study explored institutional practices and policies as they related to workload satisfaction and rewards for female faculty. Following the framework from the Faculty Workload and Rewards Project, FWRP, the case used the constructs of equity-minded faculty workloads to shape the analysis. Three themes emerged in the analysis: context matters, transparency practices, …

Complete Volume 42

Journal of the Association for Communication Administration

This is the complete Volume 42 of the Journal of the Association for Communication Administration.

Defending Form Contract Consent, Wayne R. Barnes

Faculty Scholarship

The issue of standard form contracts has bedeviled Contracts scholars for a century. The basic problem has long been known. Contract is supposed to be a quintessentially consensual activity, whereby both parties are operating with full knowledge and comprehension of the array of terms and conditions being negotiated and agreed to. But by employing standard forms replete with boilerplate fine print, companies have created a regime whereby it is most likely irrational for consumers to bother reading the terms before consenting to the transaction. The existing “duty to read” doctrine is that consumers fully consent to all terms when they …

The Integrative Role Of Melatonin In Psychiatric Disorders: A Systematic Review Of Evidence From Circadian Biology, Lifestyle Medicine, And Psychoneuroimmunology, Ho Bao Chau Le, Kollawat Somsri, Thansita Bhunyakarnjanarat, Nattiya Hirankarn, Asada Leelahavanichkul

BioMedicine

Melatonin, a hormone produced by the pineal gland, is known for regulating circadian rhythms and has emerging therapeutic potential in psychiatric disorders. This systematic review examines evidence from clinical and preclinical studies to assess melatonin’s efficacy in the following conditions: depression, anxiety, bipolar disorder, and schizophrenia. Beyond its role in circadian regulation, melatonin exhibits antioxidative, anti-inflammatory, and immunomodulatory properties, which intersect with nutrition, lifestyle medicine, and psychoneuroimmunology (PNI).

The review finds that melatonin improves sleep quality, restores circadian balance, and modulates stress-related neuroimmune pathways. It also supports neuroplasticity and reduces oxidative stress, contributing to resilience against psychosocial and environmental stressors. …

Disclosing That Which Has Been Made Invisible: Collective Ontological Inquiry With Vanessa Machado De Oliveira, Dorothy Cococinno Ladybugboss, Aiden Cinnamon Tea, And Aiden Senior, Raphael Borges, Witneiris Constanzo, Samantha Encarnacion, Kaley Klapisch, Carolyne J. White

Turning Toward Being: The Journal of Ontological Inquiry in Education

An unconventional and collaboratively written text begun as a Book Review that expands into a hybrid Book Review-Notes From The Field-Article as we sought to do justice to our encounter with three provocative books that elicit ontological inquiry inside and outside our classrooms, inquiry that challenges us, confuses us, confronts us to unlearn and loosen the grip of ontological constraints we were thrown into within modernity and our embeddedness within the everyday life. Our reading of these books elicits much needed hope for the precarious times we are living through with this earth.

Ontological Inquiry: A Foundation For Intercultural Communication Competence For Peace, Maria Stergiou

Turning Toward Being: The Journal of Ontological Inquiry in Education

Beyond what we have discovered through research and what we claim to know about learning and teaching intercultural global competencies, I advocate for the inclusion of a pedagogy of ontological inquiry. Informed by my work as the International Cooperation Advisor for Higher Education at the Swiss Agency for Exchange and Cooperation, as well as my lived experience with ontological inquiry for more than 25 years, here I illuminate the access an ontological pedagogy provides to the realization of interculturalcommunication competencies as a foundation for peace.

One Individual’S Culmination Is Another’S Abyss: The Matter Of Mattering, Lou Agosta

Turning Toward Being: The Journal of Ontological Inquiry in Education

One individual’s culmination is another’s new beginning and yet another’s abyss. The abyss is nihilism. The challenge of such a Big Idea as The Culmination (the event, not the title of Robert Pippin’s book) is to weave the hermeneutic tapestry of the meaning of Being (Sein) as disclosed in poetry, aesthetics, and the life-world, while coaxing the lumbering Hegelian camel of German Idealism through the eye of the narrow needle of Dasein’s (Heideggerian) finitude. The world and entanglement are disclosed in a nondiscursive (preconceptual) manner as mattering. The way forward in philosophy lies through innovations in “mattering”—not a conceptual sense …

Editorial Statement: Volume 3, Issue 1, Drew Kopp, Carolyne J. White

Turning Toward Being: The Journal of Ontological Inquiry in Education

No abstract provided.

Book Review Of Coloring And Learning About Cambodia In The Arts: Learning About Cambodia In The Arts, Lalinne Suon Bell

Journal of Southeast Asian American Education and Advancement

I have long been witness to the silence that trauma leaves behind. I understand how the body remembers what the tongue cannot say. The aftermath of genocide and displacement leaves not only human tragedy but also artistic ones: a fracture in how we imagine, how we create, how we see. For those of us shaped by the Cambodian diaspora, what we can’t express in words lives through art: through lines and colors. Cambodian classical dance shows this clearly: each gesture tells a story without words and that art has always been our language.

Benefits And Challenges Of Using Chatgpt: An Exploratory Study On English Language Program, Jamal Kaid Mohammed Ali

UB Journal for Humanities

This study was conducted during the early stages of ChatGPT's emergence to explore faculty members' perceptions of its benefits and challenges in the field of English as a Foreign Language (EFL). Employing an exploratory descriptive research design, the study gathered both quantitative and qualitative data from a sample of 58 faculty members at the University of Bisha, Saudi Arabia. A questionnaire consisting of closed-ended and open- ended items was utilized to collect information about the opportunities presented by ChatGPT and the challenges it poses in the field of EFL. The results indicated that while most EFL teachers held a highly …

Parallel Text In The Collection Of Poems (The Full Of Loss) By Poet Yassin Al-Bakali: Semiotic Reading, Omar Eidah Hussein Al-Harithi

UB Journal for Humanities

This research aims to shed light on the themes of loss in the collection of poems (The full of loss) by the Yemeni poet Yassin Al- Bukali. (1977). Light of a methodology that he planned for himself Especially, In the study of textual thresholds, a text-reading network leads to a comprehensible reading of the poet's poetic project. Emphasis on reading his poetic discourse through the text under study externally through its transcendentalism which intertwined with his internal discourse that is concerned with examining the functions that synergize. These together will be confirmed the dominance of the external theme of loss …

Elements Of Peaceful Coexistence And Civilized Communication In The United States Of America: An Applied Study On A Sample Of Saudi Scholarship Students, Fahad Matar F. Alshahrani

UB Journal for Humanities

Peaceful coexistence and civilized communication are an approach called for by divine laws in general, and Islamic law in particular, to achieve peace, acquaintance between people, their participation in building the land, and building positive relationships between them. Integrity of faith, working according to Islamic rulings, being characterized by forgiveness, mercy, tolerance, equality, helping others, and doing good for them and benefiting them are among the foundations of a Muslim in his dealings with others. The intellectual, religious, cultural, and social backgrounds of the Saudi scholarship student, as well as the laws and regulations in its country, are among the …

Dhat Al-Nitaqayn As Narrated In History Of The City Of Damascus By Ibn Asakir (D. 571 Ah): Structural Study, Fatimah Awaid Helail Almutairi

UB Journal for Humanities

This study focuses on the life events of Dhat al-Nitaqayn as narrated in History of the City of Damascus by Ibn Asakir (d. 571 AH), as tracking life events is a style of expression in classical Arabic language and a narrative form based on verbal communication and connected to human experience. Arabic heritage is rich with literary writings of different backgrounds from which life events are developed. This is why Ibn Asakir was keen in his book: History of the City of Damascus to document and authenticate the life events of That Al-Nitaqayn. Awaring the significance of tracking life events, …

Assessing Knowledge, Attitudes, And Consumption Of Traditional Chinese Herbal Medicine Among Filipinos Post Covid-19 Pandemic, Jane Yugioksing

Social Transformations Journal of the Global South

Traditional Chinese Medicine (TCM) in the Philippines has existed as early as the first wave of migrants but has remained confined within a prescribed settlement in the Manila district known as Parian. Over the years, TCM has existed independently as a modality of treatment to improve one’s health, mostly catering only to the Chinese in the country. At the height of the COVID-19 pandemic, the Philippines’s Food and Drug Administration (FDA) approved the use of the TCM capsule Lian Hua Qing Wen as part of the COVID-19 treatment option, which was highly patronized by the mainstream Philippine society at that …

A Certainty-Weighted, Belief-Based Model Of Political Attitudes: A Bayesian Analysis Of American Public Attitudes Toward The Affordable Care Act, Gabriel Miao Li, Josh Pasek, Jon A. Krosnick

Communication Faculty Articles and Research

This study proposes a novel, certainty-weighted account of the process by which political beliefs shape political attitudes. Building upon expectancy-value frameworks, this paper introduces belief certainty as a moderator of belief impact. A Bayesian partial-pooling approach is used to test a model positing how beliefs about what the Patient Protection and Affordable Care Act does and does not do relate to overall attitudes toward the law. This analytic method manages the complexity of multiple potentially correlated beliefs and evaluations by imposing a structural constraint to avoid multicollinearity and enable accurate estimation of parameters. Data from a nationally representative sample survey …

Uni Scholarworks Readership Snapshot, October 2025, Bepress

Library Documents & Reports (entire collection)

No abstract provided.

Young Adults And Early-Onset Psychosis: A Grounded Theory Study Of Experiences Of Identity Development, Katherine Hayden-Lewis, Deborah Rubel

The Qualitative Report

While identity development is a crucial task for young individuals ages 15-25, current research inadequately centralizes identity development in the context of first-time psychosis related to schizophrenia spectrum disorders. This study addresses the knowledge gap by exploring the grand research question, “How does a young person experience their identity development after the first episode of psychosis?”. Constructivist grounded theory methods influenced by critical frameworks were used to collect and analyze data with seven young adults engaged in first episode psychosis programs. Participants were young adults, between the ages of 19-24, that at the time of the study were enrolled in …

Translanguaging In Indonesian Efl Classrooms: Pedagogical Insights And Student Perspectives, Fauzi Miftakh, Elih Sutisna Yanto, Annisa Fitria Harjadi

The Qualitative Report

This study investigates translanguaging practices in Indonesian secondary English classrooms and analyzes how teachers and students use multiple languages to enrich the learning experience. Drawing on observations, interviews, and field notes from two teachers and four students in West Java, the study found that translanguaging fosters student comprehension, confidence, and identity affirmation. Teachers strategically used English, Indonesian, and Sundanese to scaffold instruction across various phases, creating an inclusive learning environment. Students responded positively, pointing to a reduction in anxiety and improved participation. These findings are consistent with sociocultural learning theories and challenge monolingual ideologies. The study concludes that translanguaging is …