Digital Commons Network^™

Fast And Accurate Measurement Of Small Field Dosimetry Using A Novel Scintillation Detector, Yiding Han, Jingzhu Xu, Yao Hao, Baozhou Sun

2020-Current year OA Pubs

BACKGROUND: The most used instruments for small-field dosimetry have notable limitations, including the need for correction of output factors, limited scanning speeds, and challenges in alignment for percentage depth dose (PDD) measurements, particularly for extremely small fields. However, plastic scintillation detectors (PSDs) are an attractive alternative for small-field dosimetry due to their correction-free nature, linear dose response, and fast response time.

PURPOSE: This study evaluates the robustness and accuracy of the dosimetric measurements using a new water-equivalent PSD in small-field dosimetry. The study also aims to report accurate measurements of output factors, profiles, and an indirect method for measuring PDD …

A Narrative Review On Artificial Intelligence In Neurosurgery: Ethical Challenges And Implementation Considerations, Tirath Patel, Hamza Yousuf Ibrahim, Fathimathul Henna, Fatima Nasir, Abbas Hussain, Rahma Naveed, Aziz Ur Rehman, Syeda Ramish Zehra Kazmi, Bhum Daishik Patel, Nikhilesh Anand

School of Medicine Publications

Introduction: Artificial intelligence (AI) is revolutionizing neurosurgery by enhancing diagnostic precision, surgical planning, and postoperative management. However, its integration raises ethical concerns related to bias, privacy, accountability, and the potential dehumanization of healthcare. This review focuses on navigating these challenges while maximizing AI's potential in improving patient care.

Methodology: A narrative review was conducted by identifying studies from PubMed, Cochrane Library, and Google Scholar databases. The search utilized the following keywords: "artificial intelligence," "neurosurgery," "machine learning," "data privacy," "robotic surgery," "ethics," and "bias." The review primarily focused on issues of dataset bias, data privacy, and the need for transparency and …

Satisfaction With The Saudi Healthcare System: Findings From The 2019 Kingdom Of Saudi Arabia World Health Survey, Ali M. Alzahrani, Holly C. Felix

Saudi Medical Journal

ABSTRACT Objectives: To provide details on patient satisfaction with the Saudi healthcare system and patient characteristics associated with satisfaction levels using nationally representative survey data. Methods: A cross-sectional secondary analysis was conducted using the Kingdom of Saudi Arabia World Health Survey (KSAWHS 2019) data, which collected information on demographics, health status, chronic conditions, and access to and use of healthcare services among Saudi adults aged ≥15 years. Descriptive statistics and logistics regression analyses were performed to identify significant predictors of satisfaction with Saudi healthcare services. Results: Between April and July 2019, 8,912 individuals completed the KSAWHS 2019 individual questionnaire. Out …

Rising Cancer Burden Among Older Adults In Saudi Arabia: A Longitudinal Analysis Of Incidence Rates By Demographics, 2013–2022, Hissah A. Alzahrani

Saudi Medical Journal

ABSTRACT Objectives: To analyze cancer incidence trends in Saudi Arabia from 2013 to 2022 by age group, gender, and nationality, identify significant temporal patterns or shifts, and determine the most prevalent cancer types across age groups and years. Methods: A retrospective analysis was conducted using data from the Saudi Cancer Registry, which included 185,567 reported cancer cases between 2013 and 2022. Descriptive statistics, generalized estimating equation (GEE), and Joinpoint regression were used to examine the crude incidence rate (CIR), age-specific incidence rate (AIR), and age-standardized rate (ASR) across demographic subgroups. Results: Saudi nationals had higher cancer rates than non-Saudi residents, …

Real-World Evidence Of Nusinersen Treatment For Patients With Spinal Muscular Atrophy In The Kingdom Of Saudi Arabia: Initial Insights From The Saudi National Spinal Muscular Atrophy Program, Ahmed H. Al-Jedai, Hajer Yousef Almudaiheem, Tareef Y. Alaama, Fahad Abdo Bashiri, Mohammed Abdelrahman Almuhaizae, Fouad Abdullah Alghamdi, Aljohara A. Alsakran, Fahad Zuriqan Ibrahim

Saudi Medical Journal

ABSTRACT Objectives: To assess the clinical and functional outcomes of 110 patients with spinal muscular atrophy (SMA) program who received nusinersen treatment in the Kingdom of Saudi Arabia (KSA). Methods: Motor assessments were performed using the Children’s Hospital of Philadelphia infant test of neuromuscular disorder (CHOP-INTEND) and Hammersmith infant neurological examination (HINE) for type 1 SMA, the Hammersmith Functional Motor Scale–Expanded (HFMSE) for types 2 and 3 SMA; the 6-minute walk test (6MWT) for ambulant type 3 SMA, and the revised upper limb module (RULM) for types 2 and 3 SMA. Results: Data included all SMA types (type 1, 2.72%; …

Nutritional Knowledge Of The Phenylketonuria Diet Among Healthcare Providers In Saudi Arabia, Nouf A. Alghamdi, Rouba K. Naaman

Saudi Medical Journal

ABSTRACT Objectives: Phenylketonuria (PKU) is associated with detrimental impacts on factors contributing to the etiology of obesity, and metabolism disorders. Therefore, we hypothesized that physicians and dietitians demonstrate a sufficient level of nutritional knowledge of the PKU type diet. The aim of this study is to assess understanding of the PKU diet in relation to current guidelines among dietitians and metabolic physicians in Saudi Arabia. Methods: This study involved 238 participants, primarily Saudi and non-Saudi dietitians and metabolic physicians working in Saudi Arabia, who asked to complete an electronic questionnaire assessing their nutritional knowledge of the PKU diet. The questionnaire …

Examining Public Satisfaction With The Saudi Health System: Findings From The 2019 Kingdom Of Saudi Arabia World Health Survey, Ali M. Khashab

Saudi Medical Journal

No abstract provided.

Prevention: Bend It Like Bekham, Mirvat Alasnag, Adel Tash

Saudi Medical Journal

No abstract provided.

Evaluation Of Simplified Arabic Matrix Test In Children With Normal Hearing, Medhat F. Yousef, Alia A. Asiri, Abdulmalik M. Marzuq, Abdulaziz A. Almalki, Mohammed N. Garrada, Manal A. Khoja, Ibrahim A. Busaad, Mahmoud M. Mahrous

Saudi Medical Journal

ABSTRACT Objectives: To evaluate the simplified version of the Arabic matrix test in individuals with normal hearing to derive reference ranges for future measurements with the test material. Methods The test was conducted in 80 native Arabic individuals (20 adults and 60 children across different age groups between 5-10 years) from November 2020 to Mar 2023. Evaluation measurements were conducted in adults and children to derive the reference psychometric functions and assess the training effect. The test list equivalence was verified only in the adults group. Results The reference ranges for speech-intelligibility in noise for 80% thresholds or speech-recognition threshold …

Antipsychotic Misuse: A Silent But Growing Public Health Hazard, Sumeet Bhardwaj, Karisma Pathak, Myra Mclenon, Steven Spector, Kevin Tu

Student Publications

Antipsychotic drugs are essential in the management of schizophrenia, bipolar disorder, and other psychiatric illnesses, but their use is closely linked to cardiometabolic side effects. Cardiometabolic side effects include weight gain, dyslipidemia, glucose intolerance, and increased cardiovascular morbidity and mortality. Mechanisms of cardiometabolic side effects involve disruption of the central nervous system’s ability to regulate appetite, peripheral metabolic effects, which are changes in metabolism outside the CNS, and receptor-level interactions, with second-generation antipsychotics generally posing a greater risk than first-generation agents. This review addresses current evidence on the cardiometabolic consequences of antipsychotic therapy, increasing inappropriate off-label use of antipsychotic drugs, …

Functional Head Tremor: Contrasting Features With Other Tremor Etiologies, José Fidel Baizabal-Carvallo, Joseph Jankovic

Faculty, Staff and Students Publications

Background: Functional tremor (FT) is considered the most common phenomenology among patients with functional movement disorders (FMDs). Most patients have limb tremor, but they can also present with tremor involving the head and trunk.

Objectives and methods: We aimed to assess the clinical phenomenology of functional head tremor (FHT) and contrast it with features of HT observed in 125 patients with other tremor etiologies (OTE), including 71 patients with essential tremor (ET).

Results: There were 101 consecutive patients (68.3% females) with FT from which n = 36 (35.6%) had FHT. Yes-yes tremor was the most common directionality (47.2%). Functional trunk …

Abca4-Mutant Human Retinal Organoids Sequencing Reveals Organoids Application In Inherited Retinal Diseases, Yourong Bao, Sujung Soh, Jean Li, Zhen Zuo, Salma Ferdous, Xinye Qian, Jin Li, Jiaxiong Lu, Xuesen Cheng, Anna Matynia, Yumei Li, Rui Chen

Faculty, Staff and Students Publications

In the studies of Inherited Retinal Diseases (IRDs), the knockout of traditional animal models like mice often fails to accurately replicate human phenotypes due to genetic and anatomical differences. Human retinal organoids (ROs) derived from stem cells have emerged as promising developmental models in retinal studies to delineate cell growth, but their ability to represent the characteristics of late-onset IRDs remains unclear. This study aims to validate ROs as a disease model for Stargardt's Disease (STGD) caused by ABCA4 mutations. Using single-cell RNA sequencing, ROs from 2 STGD patients were compared with healthy control-derived ROs at two developmental stages on …

Group Concept Mapping To Develop A Salon-Based Hpv Self-Collection Intervention, Kelly N B Palmer, Namoonga M Mantina, Adebola Adegboyega, Itunu O Sokale, Kathleen Pryor, Azaria Suero-Davis, Trevon Brooks, Jennifer Hatcher

Faculty, Staff and Students Publications

Background: Black women in the US face higher cervical cancer mortality rates due to delayed diagnoses linked to lower screening rates. Contributing factors include provider bias, costs, and limited access, particularly affecting women aged 40-64. While innovative approaches like clinical and home-based HPV self-collection exist, equitable dissemination remains challenging. Distributing HPV self-collection kits in unconventional sites like hair salons may offer a solution. Using concept mapping, we gathered community insights to design a salon-based cervical cancer screening intervention.

Methods: We employed groupwisdom™ and REDCap platforms for community-based participatory intervention development. Participants included members of the Black Community Advisory Council of …

Fast And Accurate Measurement Of Small Field Dosimetry Using A Novel Scintillation Detector, Yiding Han, Jingzhu Xu, Yao Hao, Baozhou Sun

Faculty, Staff and Students Publications

Background: The most used instruments for small-field dosimetry have notable limitations, including the need for correction of output factors, limited scanning speeds, and challenges in alignment for percentage depth dose (PDD) measurements, particularly for extremely small fields. However, plastic scintillation detectors (PSDs) are an attractive alternative for small-field dosimetry due to their correction-free nature, linear dose response, and fast response time.

Purpose: This study evaluates the robustness and accuracy of the dosimetric measurements using a new water-equivalent PSD in small-field dosimetry. The study also aims to report accurate measurements of output factors, profiles, and an indirect method for measuring PDD …

Constitutional Obiter Dicta On Male-Male Sex And Fundamental Rights In Singapore, Benjamin Joshua Ong

Research Collection Yong Pung How School Of Law

The Singapore Court of Appeal held a law prohibiting male–male sexual intercourse (s 377A of the Penal Code) unenforceable on non-rights-based grounds. The court's remarks about the rights to life and liberty (including whether sexual orientation is mutable), freedom of expression, and equality are obiter. But they are significant, since in Singapore, there are few constitutional rights cases and the courts focus on spelling out the limits to executive and legislative power without necessarily striking down exercises of such power on rights grounds. Indeed, the obiter dicta prompted the Legislature to repeal s 377A. Given the repeal, the obiter dicta …

Telemedicine Preexposure Prophylaxis Prescribing From A Large Online Us Company, Aaron J Siegler, Shi Hao Ernest Koh, Tristan Schukraft, Simon Mazzoni, Edwin Corbin-Gutierrez, Rupa R Patel, Patrick S Sullivan, Wenting Huang

2020-Current year OA Pubs

IMPORTANCE: HIV preexposure prophylaxis (PrEP) is highly effective in HIV prevention; telemedicine is a promising avenue for delivering PrEP care.

OBJECTIVE: To explore telemedicine delivery of PrEP care (telePrEP) by the largest telePrEP company in the US.

DESIGN, SETTING, AND PARTICIPANTS: This retrospective, single-arm cohort study used health record data of patients receiving telePrEP from MISTR LLC, a for-profit telehealth company, from November 27, 2018, to March 5, 2025. Patient characteristics and AIDSVu data were assessed to determine levels of PrEP use nationally. Retention in care was assessed for persons initiating PrEP in 2020, 2021, and 2022. Data were analyzed …

A Roadmap To Scale Up Person-Centred Care In The Hiv Response: Recommendations From A Global Consensus-Building Process, Lina Golob, Elvin H Geng, Et Al.

2020-Current year OA Pubs

INTRODUCTION: World Health Organization global normative guidance recommends person-centred care (PCC) approaches to reduce HIV-related mortality and morbidity and to improve health-related quality of life (HrQoL). However, consensus on the priority PCC elements and guidance on how different stakeholders can realize PCC principles at the health systems, service delivery and individual client-healthcare worker (HCW) levels are lacking. We conducted a global consensus-building process to define core PCC elements and develop recommendations for implementation at scale.

METHODS: We used a multi-phase process to build consensus and prioritize recommendations, consisting of a literature review, five stakeholder consultations (34-43 participants each) between July …

A Guide For Initiating And Managing Chimeric Antigen Receptor T Cell Therapy Clinical Trials In Autoimmune Rheumatic Diseases, Roberto Caricchio, Stacie Bell, Sasha Bernatsky, Maria Dall'era, David Goddard, Kenneth Kalunian, Alfred H J Kim, Fotios Koumpouras, Jose Rubio, Amit Saxena, Saira Sheikh, Lupus Clinical Investigators Network

2020-Current year OA Pubs

Chimeric antigen receptor (CAR) T-cell therapy, long transformative in oncology, is now rapidly emerging as a frontier in autoimmune rheumatic diseases, particularly systemic lupus erythematosus (SLE), driven by accumulating evidence of deep B-cell depletion, immune "resetting," and durable drug-free remission in early studies, yet its translation into rheumatology demands mastery of formidable logistical, regulatory, clinical, and ethical complexities that span institutional readiness, multidisciplinary team formation, stringent regulatory compliance, sophisticated operational workflows, comprehensive patient selection and education, meticulous clinical management of both classical toxicities (CRS, ICANS, ICAHT) and autoimmune-specific reactions such as LICATS, robust financial and resource planning, and long-term follow-up …

Introducing The Outpace Framework For Health Care Quality Improvement, Michele Bolles, Heather M. Alger, Mitchell S. V. Elkind, Howard Haft, Sabra C. Lewsey, Mariell Jessup, Karen E. Joynt Maddox, Chiadi E. Ndumele, Clyde W. Yancy, Christine Rutan, Michelle Congdon, Katherine Overton, Lynn Serdynski, Kathie Thomas, Gregg C. Fonarow

2020-Current year OA Pubs

Equitable, timely, and evidence-based care remains a central goal across health care ecosystems, yet significant quality gaps, care variability, and health disparities persist. Professional societies, including the American Heart Association, have long developed clinical practice guidelines to provide standardized, evidence-based recommendations across the cardiovascular care continuum. These guidelines are operationalized into quality measures to monitor care, identify gaps, and guide improvement. Professional societies, agencies, and health systems have applied implementation science strategies, such as education, data sharing, and evaluation, to improve care quality and achieve quality measures defined in the clinical practice guidelines. American Heart Association's Get With The Guidelines …

Does Health Insurance Coverage Improve Cardiometabolic Risk Factor Levels? Quasi-Experimental Evidence From India, Kavita Singh, Anubha Agarwal, Mark D Huffman, Et Al.

2020-Current year OA Pubs

BACKGROUND: Chronic conditions cause notable health and economic burdens. While health insurance enables access to healthcare, its effects on chronic care outcomes remain under-explored.

OBJECTIVE: To examine the association between health insurance coverage and cardiometabolic risk factors among people with chronic conditions in India.

METHODS: Data from the Centre for Cardiometabolic Risk Reduction in South Asia (CARRS) and Solan studies, including 2,926 adults with chronic conditions were analyzed using propensity score weighting to evaluate the associations between health insurance and cardiometabolic risk factors (HbA1c, low-density lipoprotein cholesterol [LDLc], and blood pressure [BP]) and self-reported health status (measured using European Quality …

Cosmetic Surgery And Physiological Disorder: You Should Talk To Someone About Your Unwinding Anxiety, Mona Muzammil, Washain Muzammil

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

Body dysmorphic disorder is a mental health condition in which you can't stop thinking about one or more perceived defects or flaws in your appearance — a flaw that appears minor or can't be seen by others. But you may feel so embarrassed, ashamed and anxious that you may avoid many social situations.

When you have body dysmorphic disorder, you intensely focus on your appearance and body image, repeatedly checking the mirror, grooming or seeking reassurance, sometimes for many hours each day. Your perceived flaw and the repetitive behaviors cause you significant distress and impact your ability to function in …

National Halo And Culture Mixing: U.S. Consumer Acceptance Of Korean Cultivated Meat Made With Seaweed Components, Mark Chong, Angela K. Y. Leung, Tricia Marjorie Fernandez

Research Collection Lee Kong Chian School Of Business

The purpose of this qualitative study was to investigate U.S. consumers’ perception and acceptance of a “culturally mixed” product – i.e., cultivated meat (beef) made with Korean seaweed components – a product that involves the blending of a foreign cultural element (Korean seaweed) with a local cultural element (cultivated beef) to create a mixed cultural representation. Subsequently, it aimed to assess if the product’s country of origin (i.e., South Korea) would influence consumer perception and acceptance. Online in-depth interviews were conducted with 20 U.S. consumers recruited through two market research companies. The interview transcripts were analyzed by two trained coders …

A Thematic Analysis Of What Australians State Would Change Their Minds On Climate Change, Amy S.G. Lee, Kelly Kirkland, Samantha K. Stanley, Abby Robinson, Zoe Leviston, Iain Walker

Research outputs 2022 to 2026

What do Australians believe would change their current opinions about climate change? In this study, we used audience segmentation analysis through the Six Americas Short Survey to identify groups of climate opinion holders within a representative sample of Australians. We had 4857 participants tell us what it would take to change their current opinions about climate change and leveraged OpenAI’s Generative Pre-Trained Transformer (GPT) to identify the presence or absence of themes (Nothing, Evidence and Information, Trusted Sources, Action, and Unsure) and subthemes in their responses. GPT performed at near-human levels, proving to be a highly useful tool for thematic …

Exploring Fathers’ Child And Family Support During Aboriginal Mothers’ Incarceration, Bon Miu, Paul Leslie Simpson, Tony Butler, Mandy Wilson, Destiny Kynuna, Robert Shaw, Jocelyn Jones

Research outputs 2022 to 2026

Aboriginal women are one of the fastest-growing subgroups among the Australian incarcerated population. Their incarceration affects increasing numbers of children, families, and communities. Few studies have examined the role of fathers when mothers are incarcerated. Using 49 in-depth interviews with Aboriginal mothers in Western Australian prisons, we explore the types of child and family support fathers provide based on the incarcerated mother’s perspective. Four themes were identified: (1) diverse support and involvement by fathers; (2) absence of father’s support due to death or incarceration; (3) parental cooperation and communication; and (4) supports and challenges to maintaining family networks. Overall, fathers …

From Mechanisms To Management: Implications Of Biogeochemical Controllers And Land Management For Soil Carbon Cycling And Storage, Savannah R. Adkins

All Graduate Theses and Dissertations, Fall 2023 to Present

Climate change and its cascading effects are driven by increases in atmospheric carbon dioxide (CO₂). Many climate solutions exists to remove this excess carbon (C) from the atmosphere, and soils, in particular, represent one of the few win-win solutions. Soils play a vital role in the global C cycle because they store more C than plants and the atmosphere combined, however, they also release more CO₂ annually than fossil fuel combustion (a major contributor to accelerating climate change). Therefore, preventing CO₂ loss from soil could help slow the progression of climate change, and increasing overall soil …

Integrating Manager Perspectives Into The Evaluation Of Wetland Revegetation Strategies, Loren F. Taylor

All Graduate Theses and Dissertations, Fall 2023 to Present

Ecological restoration is the process of assisting the recovery of an ecosystem that has been degraded and is dependent on complex and context-specific decisions. The decision-making process influencing restoration is rarely examined alongside ecological processes. There is a need for research that incorporates the social, economic, institutional, and logistical considerations that shape real-world practices, as well as ecological processes. Decisions made by restoration practitioners and land managers (hereon “manager”) are challenged by the lack of information shared regarding the practical constraints (e.g., cost, labor, specialized equipment) they face. Revegetation, particularly in wetlands, poses challenges due to site conditions and degradation …

Social Media Mining For Extracting The Experience Of Neurodivergent Individuals On Twitter (X) And Reddit, Kartik Thakkar

All Graduate Theses and Dissertations, Fall 2023 to Present

Neurodiversity refers to the natural neurological variations in the human brain such as autism spectrum disorder (ASD), attention deficit hyperactivity disorder (ADHD), dyslexia, dyspraxia, Tourette syndrome and other neurological disorders. it’s estimated that around 15% to 20% of the world’s population is neurodivergent. This means a significant portion of people experience neurological differences in how they think, learn, and interact with the world.

Social Media has become an important space for neurodivergent individuals to share their experiences, build communities, and seek support. This thesis explores how the online venues like X (Twitter) and Reddit offer themselves as digital spaces where …

Using Behavioral Skills Training To Teach School Staff To Implement Functional Communication Training, Megan Johnston

All Graduate Theses and Dissertations, Fall 2023 to Present

This project looked at how to train school staff in effective strategies for supporting students with disabilities who engage in challenging behaviors like hitting, self-injury, or crying. We taught three school staff members to use a behavioral intervention called Functional Communication Training (FCT), which helps students learn more appropriate ways to communicate their needs, while also ensuring they do not gain access to reinforcement for challenging behaviors. Staff were trained using Behavioral Skills Training (BST), a step-by-step approach that includes instructions, modeling, practice, and feedback. After the training, the school staff were able to use these strategies correctly, and the …

Predicting Major Solar Flares Using Convolutional Neural Networks And Multivariate Magnetic Field Time-Series Data, Arash Azizian Foumani

All Graduate Theses and Dissertations, Fall 2023 to Present

Major solar flares are sudden, intense bursts of X-ray energy from the Sun, capable of severely impacting critical technological infrastructure like satellites, communication networks, and power grids on Earth. Accurate prediction of these high-intensity events is crucial but presents a significant challenge. This is largely due to their infrequent occurrence and the complex, dynamic nature of the Sun's underlying magnetic activity which drives these events. This research focuses on improving the prediction of major solar flares by utilizing detailed historical data that tracks the evolution of magnetic properties within solar active regions over time. This time-based data, however, contains inherent …

The Sexual Objectification Experiences Of Amab Non-Binary People, Lee Rosemary Pradell

All Graduate Theses and Dissertations, Fall 2023 to Present

The current study combines two narrative-based methods to understand how AMAB non-binary people experience sexual objectification. Sexual objectification is the process of being treated as an object instead of as a whole person while also being sexualized. Individual people can sexually objectify others (i.e., catcalling, asking “What gender are you really?”, repeatedly asking female people about when they’re giving birth); institutions and systems can also objectify people (i.e., listing sex on driver’s licenses instead of gender; providing binary bathrooms, sports teams, and schooling; labeling female reproductive care “women’s health”).

The current study employed a process chart task that guided participants …