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Articles 38641 - 38670 of 1518678
Full-Text Articles in Entire DC Network
Upper Echelons And Corporate Venture Capital: Ceo Effects On Investment Direction And Resource Deployment, Ralph Judicael Mompoint
Upper Echelons And Corporate Venture Capital: Ceo Effects On Investment Direction And Resource Deployment, Ralph Judicael Mompoint
Graduate Theses, Dissertations, and Problem Reports (ETD)
This study examines how founder-CEO status shapes the strategic orientation of corporate venture capital (CVC) activity. Drawing on upper echelons theory, I argue that founder-CEOs differ from non-founder CEOs in where they direct CVC investments, not simply in whether they engage in CVC at all. Using a panel of S&P 500 firms spanning 2004 through 2024, I test whether founder-CEOs pursue greater CVC activity overall and whether they concentrate that activity in ventures operating within the firm's core industry. Results from random-effects negative binomial regression models show that founder-CEO status is positively associated with core-industry CVC but not with investments …
Assessing Flood Resilience In West Virginia Communities: Integrating Physical, Institutional, Socioeconomic, And Environmental Dimensions, Anahita Mahmoudi
Assessing Flood Resilience In West Virginia Communities: Integrating Physical, Institutional, Socioeconomic, And Environmental Dimensions, Anahita Mahmoudi
Graduate Theses, Dissertations, and Problem Reports (ETD)
Flooding is one of the most frequent and damaging natural hazards in the United States, with impacts expected to intensify under changing climate conditions. In regions such as West Virginia, complex terrain, development patterns along river corridors, and socioeconomic disparities contribute to elevated flood risk. Traditional approaches to flood risk assessment often focus on single dimensions of vulnerability or rely on binary floodplain maps, which do not fully capture the spatial variability and multidimensional nature of flood resilience.
This dissertation develops an integrated, community-scale framework for assessing flood resilience in West Virginia by combining physical, environmental, institutional, and socioeconomic dimensions …
The Differential Impacts Of Internal And External Corporate Social Responsibility Activities On Consumer Trust After Covid-19, Kennadi C. Mccoy
The Differential Impacts Of Internal And External Corporate Social Responsibility Activities On Consumer Trust After Covid-19, Kennadi C. Mccoy
Graduate Theses, Dissertations, and Problem Reports (ETD)
This dissertation explores the strategic role of Corporate Social Responsibility (CSR) in helping small businesses recover from crises, with a specific focus on the COVID-19 pandemic. Different from many traditional studies that highlight the ethical or reputational aspects of CSR, this research will examine its practical effects: how CSR initiatives during crises influence business success by enhancing consumer trust, particularly by examining the differential impact of Internal CSR versus External CSR. The study suggests that, compared with internally focused CSR, external CSR activities will have a greater impact on consumer trust. In addition, the dissertation suggests that this effect is …
Virtual Ensembles_ A Beginner's Guide For Recording Multitrack Audio Projects In Logic Pro, Joseph Walczyk
Virtual Ensembles_ A Beginner's Guide For Recording Multitrack Audio Projects In Logic Pro, Joseph Walczyk
Graduate Theses, Dissertations, and Problem Reports (ETD)
During the COVID-19 pandemic, musicians worldwide were suddenly unable to rehearse and perform for live audiences. This, however, did not stop people from finding ways to continue making music and perform. The idea of a virtual ensemble was not new, but it was a mystery to many. The author’s own virtual ensemble, Cinematic Brass, is one of the many groups that found continued success in producing virtual ensemble projects post-pandemic. This research aims to demystify the process, helping beginners take their first steps towards high-quality virtual ensemble audio recordings. Included are equipment recommendations, examples of file organization and communication, recording …
Evaluation Of Brook Trout (Salvelinus Fontinalis) Thermal Tolerance And Projected Climate Change Effects On Headwater Brook Trout Population Persistence, Cory Bauerlien
Graduate Theses, Dissertations, and Problem Reports (ETD)
Climate change has been identified as one of the greatest threats to global biota in recorded human history. Consequences are expected to be more pronounced in ectotherms because most of their physiology is controlled by external temperature conditions. Predicting how ectotherms may respond to increasing global temperatures necessitates information about thermal limits of thermal sensitive species and how increasing temperatures may affect individual and population-level fitness. Therefore, the objectives of this research were aimed at gaining a better understanding of the mechanisms that underpin thermal tolerance limits of fish and how those mechanisms may affect fitness and population persistence under …
A Constraint-Based Approach To Developing Melodic Improvisational Skills In Intermediate Jazz Piano Students, Alton Xian Rong Wong
A Constraint-Based Approach To Developing Melodic Improvisational Skills In Intermediate Jazz Piano Students, Alton Xian Rong Wong
Graduate Theses, Dissertations, and Problem Reports (ETD)
This study examines the pedagogical value of a constraint-based approach in helping students develop improvisational fluency and coherence by facilitating audiation. Although there are pedagogical texts on jazz improvisation that incorporate exercises shaped by constraint-based thinking, there is neither a systematic framework for their application with students of varying levels and musical backgrounds, nor a clear explanation of their pedagogical purpose. This research investigates how constraint-based pedagogy, through the lens of rhythmic, harmonic, and melodic parameters, can be applied independently or collectively to support the development of improvisational fluency in intermediate level jazz piano improvisers. It argues that musical constraints …
Bridging Physics-Based Modeling And Machine Learning To Predict Material Behavior: Applications In Fatigue Crack Growth And Dielectric Property Characterization, Ansan Pokharel
Graduate Theses, Dissertations, and Problem Reports (ETD)
This dissertation integrates physics-based modeling with machine learning (ML) to predict how materials behave under complex thermal and mechanical conditions. A key innovation of this work is the use of finite element analysis (FEA) to supplement experimental data. This approach creates more diverse and representative synthetic datasets, helping to reduce the limitations and biases that arise when training ML models solely on experimental measurements. The research focuses on two applications: improving the prediction of fatigue properties in superalloys and estimating temperature-dependent, high-frequency dielectric properties relevant to microwave-based chemical processing.
In the first study, low-cycle fatigue experiments were performed on the …
More Than A Man: An Ethnomusicological Survey Of The Folklore Of John Henry And Resource Guide For “More Than A Man” By Shanyse Strickland, Clayton R. Heath
More Than A Man: An Ethnomusicological Survey Of The Folklore Of John Henry And Resource Guide For “More Than A Man” By Shanyse Strickland, Clayton R. Heath
Graduate Theses, Dissertations, and Problem Reports (ETD)
“John Henry” exists as an enduring folk legend in the United States of America, representing the confluence of the Reconstruction Era, the economic utility of Appalachia and the Westward expansion of industry which left it behind. Though based on historical events, Henry’s fictional representation has diverted and evolved in music and other media from its inception in the oral tradition to the modern age. Through this progression, shared symbols have circulated, gathering embedded meanings and associating the folklore with specific communities. Henry’s representational identity has been signaled with the creation and distribution of each version of his story, both complicating …
A Prospective Analysis Of Success And Survival Of Haptic Robotically Driven Dental Implant Placement., Samuel Clarkman Smith
A Prospective Analysis Of Success And Survival Of Haptic Robotically Driven Dental Implant Placement., Samuel Clarkman Smith
Graduate Theses, Dissertations, and Problem Reports (ETD)
Purpose: The aim of this prospective study was to assess survivability of dental implants placed using robotic computer aided implant surgery via Yomi® (Neocis, Inc. Miami, FL) after at least 1 year of functional loading. Secondary analysis included additional success and marginal bone loss outcomes after at least 1 year of functional loading of the same Straumann (Basel, Switzerland) titanium dental implants that were placed with the r-CAIS workflow. Materials and Methods: Since acquisition of the Yomi® robotic system, a comprehensive list of patients who underwent dental implant therapy via r-CAIS methodology at West Virginia University Department of Graduate Periodontics …
High-Resolution Laser Diagnostics For Ion Measurements In Magnetized Plasmas, Katey Stevenson
High-Resolution Laser Diagnostics For Ion Measurements In Magnetized Plasmas, Katey Stevenson
Graduate Theses, Dissertations, and Problem Reports (ETD)
In this work, we investigate ion heating in two plasma systems (helicon plasmas and flux rope plasmas) using the PHAse Space MApping (PHASMA) experiment. Our studies rely on high-resolution laser diagnostics, specifically laser-induced fluorescence (LIF), to measure ion velocity distribution functions (IVDFs). The temperature and bulk flow of each species are inferred from their respective VDFs. This dissertation is organized into three main parts: the study of ion heating in helicon plasmas, pulsed LIF modeling and diagnostic development, and the study of ion heating in flux rope plasmas. Helicon plasma sources efficiently generate high-density plasmas and are widely used to …
Utilizing Plethodontid Occupancy To Assess Initial Ecosystem Responses To Invasive Plant Control Treatment In The Central Hardwoods, Maree Guinevere Dieterich
Utilizing Plethodontid Occupancy To Assess Initial Ecosystem Responses To Invasive Plant Control Treatment In The Central Hardwoods, Maree Guinevere Dieterich
Graduate Theses, Dissertations, and Problem Reports (ETD)
Invasive plants are a growing concern for land managers, impacting ecosystem resilience and outcompeting native vegetation. To combat this, invasive plant control treatments can assist in reducing the impacts and spread of damaging, non-native plant species. However, intensive treatments completed at large scales have the potential to negatively impact ecosystem services as well. To monitor these impacts, I utilized a well-known indicator in the Central Applachian region, Plethodontid salamanders, to assess impacts of invasive plant control treatments in the Central Hardwood forests. I completed 12 visual samples across 60 sites in West Virginia, USA during Spring and Fall of 2025 …
Graded Repertoire For Violin By Latin American Composers: Pedagogical Analysis And Categorization Of Selected Pieces, Irene Guerra Rudas
Graded Repertoire For Violin By Latin American Composers: Pedagogical Analysis And Categorization Of Selected Pieces, Irene Guerra Rudas
Graduate Theses, Dissertations, and Problem Reports (ETD)
Repertoire sequences have evolved from a collection of technical studies into a comprehensive educational framework. This research aims to enhance the integration of innovative pedagogical materials by identifying, analyzing, and categorizing works originally composed for violin by Latin American composers. These works are assessed for their suitability within a structured violin curriculum and organized into graded levels, ranging from elementary to advanced.
Each selected piece is evaluated according to pedagogical parameters commonly used in established violin teaching traditions. These parameters include pitch range, rhythmic complexity, bow strokes, length, stylistic diversity, musical language, and the historical and cultural relevance of both …
Student And Teacher Perceptions Of Confirming Behaviors Across Instructional Modalities, April Nicole Wright
Student And Teacher Perceptions Of Confirming Behaviors Across Instructional Modalities, April Nicole Wright
Graduate Theses, Dissertations, and Problem Reports (ETD)
This dissertation examined how undergraduate students and instructors evaluate lowinference teacher confirmation behaviors across instructional modalities and identified additional behaviors perceived as confirming in contemporary instructional contexts. Participants included 274 undergraduate students and 104 higher-education instructors who completed a survey measuring four clusters of confirming behaviors (willingness to engage, recognition, acknowledgment, and endorsement) using a 7-point Likert-type scale. Open-ended questions invited participants to describe confirming behaviors not represented in existing measures. Results indicated that both students and instructors rated most behaviors above the midpoint of the scale, with instructional responsiveness and course organization receiving the highest ratings. Instructors rated all …
A Digital Calibration Source For 21 Cm Cosmology Telescopes, Kalyani Balkrishna Bhopi
A Digital Calibration Source For 21 Cm Cosmology Telescopes, Kalyani Balkrishna Bhopi
Graduate Theses, Dissertations, and Problem Reports (ETD)
Precise calibration of radio telescope beams and gains is a central requirement for 21 cm intensity mapping experiments, which aim to measure large scale cosmological structure through the redshifted emission line of neutral hydrogen. Bright astrophysical foregrounds dominate the sky at these frequencies, and separating them from the cosmological signal demands precise control over instrumental systematics, particularly the telescope beam and its frequency-dependent response. Existing aerial calibration sources are incoherent broadband emitters, detectable only as total power. They provide no direct phase information and suffer from poor sensitivity in low signal-to-noise regimes.
We present the Precision Emitter for 21cm Array …
Ai-Driven Prediction And Reconstruction Of Missing Cased-Hole Logs For Improved Well System Understanding, Samuel Avilez Martinez
Ai-Driven Prediction And Reconstruction Of Missing Cased-Hole Logs For Improved Well System Understanding, Samuel Avilez Martinez
Graduate Theses, Dissertations, and Problem Reports (ETD)
Well logging is a fundamental technique in formation evaluation providing continuous, real-time measurements of geological and petrophysical properties within a well. Through the systematic analysis of well logs, engineers and geoscientists can accurately determine critical formation characteristics, including porosity, permeability, lithology, and fluid composition. Well logging is fundamental for making informed decisions and reducing uncertainties in the exploration and development of oil and gas reservoirs.
Despite its significance, the acquisition of reliable well log data in oil and gas wells is often compromised by various operational, mechanical, and formation-related challenges, as well as pressure, fluid, and equipment constraints. In high-risk …
The Impact Of Ai Service Workers On Opportunistic Complaint Behavior, Chelsi J. Baker
The Impact Of Ai Service Workers On Opportunistic Complaint Behavior, Chelsi J. Baker
Graduate Theses, Dissertations, and Problem Reports (ETD)
Consumer complaint behavior research has traditionally focused on interactions between customers and human employees, leaving open questions about how these behaviors may change when the service agent is artificial intelligence. This research looks at whether customers are more likely to engage in opportunistic complaint behavior when interacting with AI service agents and explores what might explain that behavior. The results show that customers are more likely to behave opportunistically when interacting with AI service agents than with human employees. Perceived morality helps explain this relationship, as more human-like service agents increase the extent to which exaggerating a complaint is seen …
Congolese Journalists: Professional Identity And Legitimacy, Hannah L. Heiskell
Congolese Journalists: Professional Identity And Legitimacy, Hannah L. Heiskell
Graduate Theses, Dissertations, and Problem Reports (ETD)
This paper examines how Congolese journalists construct their professional identity
and legitimacy while working under conditions of conflict and state pressure, and how
international media outlets discursively represent them through Western journalistic norms.
Addressing previous research and centering local perspectives, this study uses critical
discourse analysis to compare language, framing, and narratives across Congolese and
international media texts, and the works in which they produce. Attention is given to how
agency, professionalism, and constraint are represented within each discourse. The analysis
focuses on metajournalistic discourse, or journalism talking about journalism, to examine
how professional norms and boundaries are articulated and …
Exploring The Role Of Occupational Therapy In A Pediatric Specialty Care Office, Sierra Leigh Hays
Exploring The Role Of Occupational Therapy In A Pediatric Specialty Care Office, Sierra Leigh Hays
Graduate Theses, Dissertations, and Problem Reports (ETD)
Introduction: The role of OT in primary and specialty care clinics is a rising area of interest in the field. There are also many multidisciplinary clinics that OTs can be or are apart of. This study aims to evaluate the consulting role of OT in primary and specialty care clinics, as well as to evaluate data collected by an OT in a pediatric brachial plexus and peripheral nerve clinic. Methods: The first objective was focused on analyzing functional outcomes, using the Active Movement Scale (AMS), of children following neurosurgery or onabotulinum toxin A injections. This was a retrospective study with …
Back To The Office Or Out The Door: The Impact Of Return-To-Office Mandates On Employee Well-Being And Turnover Intention, Charlotte Renee Nelson
Back To The Office Or Out The Door: The Impact Of Return-To-Office Mandates On Employee Well-Being And Turnover Intention, Charlotte Renee Nelson
Graduate Theses, Dissertations, and Problem Reports (ETD)
The widespread adoption of remote work during the COVID-19 pandemic significantly altered traditional workplace arrangements. As organizations increasingly implement RTO mandates, questions have emerged about how these changes affect employee well-being and turnover intentions. Guided by the Job Demands–Resources framework, this study examined the relationship between RTO mandates and two employee outcomes: employee well-being and turnover intention. The study also tested whether work engagement mediated these relationships and whether perceived organizational support and work stressors moderated the relationship between RTO mandates and work engagement.
A quantitative, non-experimental, cross-sectional survey design was employed. Data were collected from 229 U.S. employees working …
Impact Of Occupational Therapy Within The Rosenbaum Family House: How Program Development Supports Health And Well-Being For Caregivers And Care Recipients, Zaccardi P. Muniz
Impact Of Occupational Therapy Within The Rosenbaum Family House: How Program Development Supports Health And Well-Being For Caregivers And Care Recipients, Zaccardi P. Muniz
Graduate Theses, Dissertations, and Problem Reports (ETD)
Healthcare hospitality houses (HHH) are designed to accommodate patients and caregivers receiving medical treatment far from home. The Rosenbaum Family House (RFH) acts as the HHH adjacent to J.W. Ruby Memorial Hospital in Morgantown, West Virginia. The RFH offers amenities that meet the basic needs of guests; However, there is an opportunity for occupational therapy-based program development to help further assist caregivers and care recipients both inside and outside the RFH. During the doctoral capstone experience (DCE), a three-phase project was developed to support the health and well-being of guests and WVUMedicine clients through group programming, resource guide development, and …
Enhancing Occupational Engagement And Wellness In Middle-Aged And Retired Adults Through Movement And Mindfulness Program Development, Erin J. Harvey
Enhancing Occupational Engagement And Wellness In Middle-Aged And Retired Adults Through Movement And Mindfulness Program Development, Erin J. Harvey
Graduate Theses, Dissertations, and Problem Reports (ETD)
Occupational imbalance and a diminished sense of purpose are common challenges faced during middle age and the transition into retirement. These issues can contribute to increased burnout, decreased participation in meaningful activities, and an overall decline in health and well-being. Occupational therapy is well-equipped to address these concerns through comprehensive and holistic, occupation-based wellness programs that promote healthy routines and engagement in meaningful roles. This doctoral capstone project involved developing and implementing two community-based wellness programs tailored to different populations. The first program included self-paced wellness modules for middle-aged adults, aiming to encourage healthy lifestyle habits, enhance coping skills, and …
A Quality Improvement Initiative To Improve Central Line Insertion Care Using An Evidence- Based Practice Checklist, Jonathan Andre Barbour
A Quality Improvement Initiative To Improve Central Line Insertion Care Using An Evidence- Based Practice Checklist, Jonathan Andre Barbour
Graduate Theses, Dissertations, and Problem Reports (ETD)
Background: Central line infections in a 33-bed Cardiovascular Intensive Care Unit (CVICU) at a large academic medical center located in the northeastern United States were increasing for patients after cardiovascular surgery. These infections could, potentially, lead to longer hospital stays and lost revenues for the health system. A project explored the implementation of an evidence-based practice (EBP) sterile procedure standardized checklist during central line insertions
Purpose: A quality improvement (QI) initiative project sought to improve central line insertion compliance while monitoring the bedside implementation of an EBP checklist.
Intervention: The Agency for Healthcare Research and Quality’s (AHRQ) Central line-associated bloodstream …
Behavioral Adaptation To Systematically Changing Local Conditions Of Reinforcement, Kento Yasukawa
Behavioral Adaptation To Systematically Changing Local Conditions Of Reinforcement, Kento Yasukawa
Graduate Theses, Dissertations, and Problem Reports (ETD)
Adaptation is the continual process of behavioral change in response to changes in environmental contingencies. One example of adaptation is to track the temporal distribution of reinforcers. The present dissertation investigated how responding tracked cyclically changing reinforcement schedules (i.e., cyclic interval [CI]) and how such tracking was influenced by concurrently available alternative reinforcement schedules. Across two experiments, four pigeons responded under a CI 60-s schedule in which the interreinforcer intervals (IRIs) changed systematically according to a sinusoidal function. The primary dependent variable was postreinforcement pauses (PRPs), with local response rates (response rates per IRI) examined as a secondary measure of …
Feasibility Of Parent-Child Interaction Therapy-Toddler In Community Clinics In The United States And Japan, Sharon T. Phillips
Feasibility Of Parent-Child Interaction Therapy-Toddler In Community Clinics In The United States And Japan, Sharon T. Phillips
Graduate Theses, Dissertations, and Problem Reports (ETD)
The toddler age (12-36 months) is characterized by a toddler’s increasing desire for autonomy, which can result in caregiver-child conflict and toddler externalizing problems (Kohlhoff & Morgan, 2014). Clinical levels of disruptive behavior in toddlerhood can be predictive of a host of negative outcomes, including problems with academic achievement and delinquency (Copeland et al., 2007; Milledge et al., 2019). High levels of toddler behavior problems also are associated with poor caregiver-child relationships and poor toddler emotion regulation skills (Beijers et al., 2013; Umemura et al., 2022). Thus, interventions targeting toddler behavior problems need to focus on strengthening the caregiver-child relationship …
Social Media Appearance Pressures And Body Dissatisfaction In Collegiate Athletes: Model Refinement, Group Differences, And Exploratory Insights, Hannah Hunter Miller
Social Media Appearance Pressures And Body Dissatisfaction In Collegiate Athletes: Model Refinement, Group Differences, And Exploratory Insights, Hannah Hunter Miller
Graduate Theses, Dissertations, and Problem Reports (ETD)
In considering athletes’ body image, it is necessary to examine the psychosocial factors, and related psychological processes, that influence it. The body-related pressures athletes experience while navigating social media represent a relatively new and increasingly influential factor that warrants further investigation. The purpose of this study was threefold: (1) to replicate and refine Miller and colleagues’ (in press) model; (2) to examine differences in model variables and relationships across demographic and contextual groups; and (3) to explore aspects of social media perceived as contributing to appearance pressures, as well as strategies athletes may use to mitigate these pressures and their …
Real-Time Lidar-Based Vehicle Detection Using Pointpillars For Connected And Automated Vehicle Applications, Jared Townsend Behr
Real-Time Lidar-Based Vehicle Detection Using Pointpillars For Connected And Automated Vehicle Applications, Jared Townsend Behr
Graduate Theses, Dissertations, and Problem Reports (ETD)
This work explores the implementation of a real-time LiDAR processing model for autonomous vehicle design. Automotive perception systems are becoming increasingly important as Advanced Driver Assistance Systems (ADAS) and Connected and Automated Vehicle (CAV) technologies continue to progress toward higher levels of autonomy. Reliable perception is paramount for autonomous features, such as adaptive cruise control (ACC), where identifying and tracking a lead vehicle is a safety critical task.
Many production ADAS perception systems primarily rely on radar and camera sensors for object detection and sensor fusion. These sensors work well to achieve classification and accurate distance detections; however, they are …
Ornithine Metabolism In Retinal Pigment Epithelium And Retina And Implications In Gyrate Atrophy, Artjola Puja
Ornithine Metabolism In Retinal Pigment Epithelium And Retina And Implications In Gyrate Atrophy, Artjola Puja
Graduate Theses, Dissertations, and Problem Reports (ETD)
Ornithine aminotransferase (OAT) is a mitochondrial enzyme that regulates ornithine metabolism by converting ornithine to pyrroline-5-carboxylate, a precursor for proline and glutamate synthesis. Deficiency of OAT causes systemic ornithine accumulation and leads to gyrate atrophy (GA) of the choroid and retina, a hereditary disorder characterized by progressive chorioretinal degeneration and irreversible vision loss. Chorioretinal atrophy typically starts at the mid-peripheral retina and progresses toward the macula. Although elevated ornithine is considered toxic to the eye, how ornithine is metabolized in ocular tissues and why OAT deficiency causes selective, region-specific vulnerability remain unclear. We combined ex vivo and in vivo stable …
Swarm Of One: Self-Organization In Multicellular Robots, Trevor Riley Smith
Swarm Of One: Self-Organization In Multicellular Robots, Trevor Riley Smith
Graduate Theses, Dissertations, and Problem Reports (ETD)
Designing robots traditionally relies on centralized, top-down methods that constrain adaptability and resiliency, producing systems optimized for specific tasks. However, such systems often fail in complex environments, such as extraterrestrial, disaster, or natural settings, where designers cannot foresee every scenario a robot may encounter. Achieving autonomy in these contexts requires robots that are resilient and capable of adapting to the unknown. Multicellular organisms exhibit this adaptability through self-organization, where complex structures and behaviors emerge from local interactions among their cells. Such organisms can be viewed simultaneously as a single entity and a swarm of cooperating cells, i.e., a Swarm-of-One.
This …
Mechanisms Of Glyphosate Toxicity: Uptake, Mitochondrial Function, And Metabolism, Dionysios Patriarcheas
Mechanisms Of Glyphosate Toxicity: Uptake, Mitochondrial Function, And Metabolism, Dionysios Patriarcheas
Graduate Theses, Dissertations, and Problem Reports (ETD)
Glyphosate, the most widely used herbicide in the world, is an inhibitor of chorismate biosynthesis, the precursor of aromatic amino acids. The target of glyphosate is absent in animals, but findings reporting toxicity in model organisms without a known mechanism or target are increasing. Saccharomyces cerevisiae is a useful and versatile model for understanding molecular mechanisms of toxicity. In yeast, previous work has shown that the aspartate/glutamate permease Dip5 is the proposed transporter for glyphosate and that mitochondrial metabolism has been implicated in response to glyphosate toxicity. This dissertation aimed to identify the effects of glyphosate on mitochondrial function through …
Electronic Cigarettes Increase Blood-Brain And Blood-Tumor Barrier Drug Efflux In A Preclinical Lung Cancer Model Of Brain Metastasis, Cullen Parker Wolford
Electronic Cigarettes Increase Blood-Brain And Blood-Tumor Barrier Drug Efflux In A Preclinical Lung Cancer Model Of Brain Metastasis, Cullen Parker Wolford
Graduate Theses, Dissertations, and Problem Reports (ETD)
This dissertation (a) provided a comprehensive review of the known therapeutic challenges in nicotine delivery system users with lung cancer and (b) investigated the impact of electronic cigarettes on blood-brain/blood-tumor barrier function and efficacy of small molecule KRAS inhibitors in a syngeneic lung cancer brain metastasis model. The blood-brain barrier is a physiochemical barrier that limits systemic delivery of therapeutics into brain. When tumors invade the central nervous system, the blood-brain barrier is disrupted and subsequently forms a blood-tumor barrier. Despite the inherent leakiness and variable permeability of the blood-tumor barrier, it continues to restrict anti-cancer drugs from accumulating at …