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Articles 37171 - 37200 of 1519397
Full-Text Articles in Entire DC Network
How Dentists Can Remain Advisors Of Merit To Their Patients, Daniel L. Orr Ii, Dds, Ms (Anesth), Phd, Jd, Md, Facd (Nevada Section Chair)
How Dentists Can Remain Advisors Of Merit To Their Patients, Daniel L. Orr Ii, Dds, Ms (Anesth), Phd, Jd, Md, Facd (Nevada Section Chair)
Journal of the American College of Dentists
This article examines how members of the dental profession can sustain their longstanding reputation as trusted advisors amid declining public confidence in major institutions. Grounded in ethical principles, informed consent, and professional self-regulation, dentistry has historically ranked among the most trusted professions. The discussion explores challenges to credibility, including media scrutiny, concerns about anesthesia safety, controversial treatment hesitancy, and debates over community water fluoridation. Emphasizing the concept of the “advisor of merit,” the author argues that continued trust depends on truthful communication, transparency about risks, respect for patient autonomy, and freedom from conflicts of interest in clinical and public health …
From The Archives: Continued Competency Assessment: Its History And Role In The Health Professions
From The Archives: Continued Competency Assessment: Its History And Role In The Health Professions
Journal of the American College of Dentists
Each issue of the Journal of the American College of Dentists (JACD) features an archival article selected for its continued relevance to contemporary issues in dentistry. This article provides historical context and enduring insights that inform current discussions in the profession.
J Am Coll Dent 2026 92 4
Journal of the American College of Dentists
The Journal of the American College of Dentists (JACD) publishes scholarly articles, editorials, essays, and reflections addressing the ethical, professional, and social dimensions of dentistry. The Journal serves as a forum for advancing ethics, professionalism, leadership, and excellence within the dental community. By fostering dialogue across disciplines and perspectives, JACD provides readers with insights that encourage ethical, professional practice, lifelong learning, and service to the public, reinforcing dentistry’s commitment to advancing oral healthcare and the common good.
Core Standards For Leadership In Oral Healthcare, Sir Nairn H.F. Wilson Cbe Dsc(H.C.) Ddent(H.C.) Phd Msc Bds Fcgdent Fds Rcs Edin, Eng(Hon) & Rcps Glasg(Hon) Ffd Rcsi(Hon) Fcdshk(Hon) Fracds(Hon) Drd Fhea Facd Ficd Fadm Fpfa Frsm Fkc
Core Standards For Leadership In Oral Healthcare, Sir Nairn H.F. Wilson Cbe Dsc(H.C.) Ddent(H.C.) Phd Msc Bds Fcgdent Fds Rcs Edin, Eng(Hon) & Rcps Glasg(Hon) Ffd Rcsi(Hon) Fcdshk(Hon) Fracds(Hon) Drd Fhea Facd Ficd Fadm Fpfa Frsm Fkc
Journal of the American College of Dentists
This article introduces the American College of Dentists’ core standards for leadership in oral healthcare, grounded in well-established ethical principles and in response to ever-increasing expectations for patient-first care. It is suggested that the new standards must be consistently upheld to maintain patient trust and professional credibility. Effective leadership, in contrast to management, improves patient engagement and outcomes, team performance, and resilience. The article calls for more leadership training in dentistry, beginning in dental schools, and highlights the need for effective leadership in oral healthcare to strengthen the profession’s standing and status.
Standards For Leadership In Oral Health Care. A Project Of The Board Of Regents Of The American College Of Dentists, Robert A. Faiella Dmd, Mmsc., Mba, Teresa A. Dolan Dds, Mph, Facd, N. Karl Haden Phd, Facd, Sreenivas Koka Dds, Ms, Phd, Mba, Mas, Facd, Sir Nairn H.F. Wilson Cbe Dsc(H.C.) Ddent(H.C.) Phd Msc Bds Fcgdent Fds Rcs Edin, Eng(Hon) & Rcps Glasg(Hon) Ffd Rcsi(Hon) Fcdshk(Hon) Fracds(Hon) Drd Fhea Facd Ficd Fadm Fpfa Frsm Fkc
Standards For Leadership In Oral Health Care. A Project Of The Board Of Regents Of The American College Of Dentists, Robert A. Faiella Dmd, Mmsc., Mba, Teresa A. Dolan Dds, Mph, Facd, N. Karl Haden Phd, Facd, Sreenivas Koka Dds, Ms, Phd, Mba, Mas, Facd, Sir Nairn H.F. Wilson Cbe Dsc(H.C.) Ddent(H.C.) Phd Msc Bds Fcgdent Fds Rcs Edin, Eng(Hon) & Rcps Glasg(Hon) Ffd Rcsi(Hon) Fcdshk(Hon) Fracds(Hon) Drd Fhea Facd Ficd Fadm Fpfa Frsm Fkc
Journal of the American College of Dentists
This section of the Journal of the American College of Dentists presents professional conference proceedings and/or published guidelines relevant to dentistry, ethics, education, leadership, policy, or clinical care. Conference proceedings may also include documents from affiliate organizations in dentistry.
Empathy And Human-Centered Leadership In Community Health Center Dental Clinics, Pamela S. Alston Dds, Mpp, Facd
Empathy And Human-Centered Leadership In Community Health Center Dental Clinics, Pamela S. Alston Dds, Mpp, Facd
Journal of the American College of Dentists
A person-centered approach, with empathy toward patients, can improve satisfaction among both patients and dental health professionals. A dental director with a human-centered leadership style can improve the well-being of oral health team members. This article describes the role that empathy, a core value of humanism and professionalism, plays in accomplishing these improvements in community health center dental clinics. This article also describes the risks of empathy, as experienced by the author in her role as a dental director and practitioner, as well as documented in the literature. It further focuses on dental directors’ human-centered approaches to supporting oral health …
The History Of Dr. Suess And European Dentists From The Past: Relevant Lessons In Bioethics For Today, Howard A. Israel Dds, Facd
The History Of Dr. Suess And European Dentists From The Past: Relevant Lessons In Bioethics For Today, Howard A. Israel Dds, Facd
Journal of the American College of Dentists
The works of the author-illustrator Dr. Seuss evoke images of children’s books with moral themes, such as Yertle the Turtle and Horton Hears a Who. The life story of another Dr. Suess has remained relatively unknown. Walter Suess was an extremely talented dentist and musician in Austria. Brilliant and courageous, he became a victim of a morally depraved authoritarian regime and the absence of biomedical ethics during the reign of the Third Reich. The serendipitous discovery of the true story of Dr. Seuss and European dentists from this era offers lessons in bioethics relevant to today.
The Personal, Professional, And Practice: Integrating Health Humanities Into Dental Education, Margie Hodges Shaw Jd, Ma, Phd, Michael Yunker Dds, Nicholas Mercado Drph, Ms
The Personal, Professional, And Practice: Integrating Health Humanities Into Dental Education, Margie Hodges Shaw Jd, Ma, Phd, Michael Yunker Dds, Nicholas Mercado Drph, Ms
Journal of the American College of Dentists
Dentistry’s evolution as a profession reflects both scientific progress and enduring tensions between commercial and service-oriented models of care. Despite long-standing commitments to ethical education, dental training continues to privilege technical mastery over professional identity formation, leaving some future practitioners underprepared for the ethical and relational complexities of clinical practice. This paper situates these challenges within the historical separation of dentistry and medicine and argues that integrating the health humanities into dental education can strengthen professional identity formation and clinical ethics competency. Using a case study, we demonstrate how biases, professional obligations, and patient trust intersect in practice. We introduce …
The Persistent Shock Of The Old: Making The Case For The Responsive Development Of Artwork Deploying Historical Museological Display Techniques., Duncan Cameron
The Persistent Shock Of The Old: Making The Case For The Responsive Development Of Artwork Deploying Historical Museological Display Techniques., Duncan Cameron
School of Art, Design and Architecture Theses
My sculpture work and thesis investigate the potential of historical museological practices—particularly Victorian and Edwardian display technologies—in contemporary art-making and sculptural practice. I ask three central questions: how can the collection and display of natural history materials be ethically defended in the present day; how might traditional exhibition orthodoxies be reconfigured to privilege the prosaic, domestic, and handmade over the novel and precious; and what role does the idiosyncratic and beautiful play in narrating material stories within an ethical, Anthropocene-aware framework?The study employs a practice-led methodology combining iterative art-making, critical reflection, and active fieldwork. Working from a studio in Somerset, …
A Balm For The Broken: Bearing The Scars And Songs Of Generational Survival In A World That Denies Our Humanity, Desmond Beach
A Balm For The Broken: Bearing The Scars And Songs Of Generational Survival In A World That Denies Our Humanity, Desmond Beach
School of Art, Design and Architecture Theses
“We survived to tell the tale.” This dissertation explores the intersections of visual art, Black cultural memory, and spiritual labor through a body of creative and scholarly work rooted in Black textile traditions. Informed by the artist’s upbringing in West Baltimore and shaped by the spiritual and communal practices of the Black church, the research considers artmaking as a form of ritual, resistance, and remembrance. Patchwork, performance, and mixed media installations become not only expressive gestures but also repositories of intergenerational memory, sites of ancestral presence, and acts of survival that exceed mere endurance.The dissertation integrates creative production with critical …
Planetarity And Relation: Ecology As Method, Ashish Ghadiali
Planetarity And Relation: Ecology As Method, Ashish Ghadiali
School of Art, Design and Architecture Theses
The List of Works submitted comprises research through film, text, exhibition, performance and policy engagement, developed during a three-year period from 2021 to 2024 in the site-specific location of Southwest England. This multi-modal and interdisciplinary practice is framed in response to the question of how art and cultural strategy can, in the contexts of climate breakdown and global racial inequity, be conceived of as agency for environmental justice. In this integrative summary, I present a theoretical framework where ecology, in response to conditions of environmental crisis, is understood not only as a subject of inquiry but also as method. In …
The Influence Of Historical Technological Constraints On Contemporary Music Practice, Clive Mead
The Influence Of Historical Technological Constraints On Contemporary Music Practice, Clive Mead
School of Art, Design and Architecture Theses
This practice-based research project explores the creative implications of working within historically constrained music production environments. By composing and producing original music using only emulated instruments, effects, and recording technologies from four key eras—1955, 1965, 1975, and 1985—the study examines how technological limitations affect contemporary compositional practice. The project is situated at the intersection of music production, creative practice research, and is conducted by a composer-producer with extensive experience across diverse musical genres.The research addresses three central questions: What occurs when a proficient modern producer is restricted to using tools from earlier periods of recorded music history? In what ways …
Feminism, Domestic Abuse And The Singer-Songwriter, Kathryn Ferguson
Feminism, Domestic Abuse And The Singer-Songwriter, Kathryn Ferguson
School of Art, Design and Architecture Theses
This project explores how feminism and domestic abuse can be articulatedthrough songwriting. Research in music therapy, sociology and popular musicincreasingly speaks to the value of songwriting as a tool for personal andcommunity empowerment, but there is space to actively use songwriting toexplore feminist issues independently of the traditional commercial context ofpopular music. Existing feminist music has been deemed as at its mostsuccessful when it is linked clearly to social change in our communities(Greene, 2017, p.8). Modern popular feminist songwriting has been criticised fornot going far enough in deconstructing systemic patterns of patriarchy (Tong,2024, p.9). Considering this, engaging with academic research …
Hehanyela Istogmuzapi S’E Unk’Unpi Sni (Blind No More): Storying Transgenerational Healing And Relational Indigenous Leadership Through Practitioner Research, Dowan Wasté Win Tamera Miyasato
Hehanyela Istogmuzapi S’E Unk’Unpi Sni (Blind No More): Storying Transgenerational Healing And Relational Indigenous Leadership Through Practitioner Research, Dowan Wasté Win Tamera Miyasato
Dissertations and Theses
This dissertation, Hehanyela Istogmuzapi S’e Unk’unpi Sni (Blind No More), examines how Indigenous leadership emerges through transgenerational healing, story, and relational accountability. Grounded in Indigenous methodologies and guided by Absolon’s (2022) Kaandossiwin framework, this practitioner research positions story not as data to be analyzed, but as method, theory, and ceremony. It asks how healing inherited wounds through story, memory, and land shapes Indigenous approaches to leadership and restores relational responsibility within educational and community spaces. The work unfolds through intergenerational and transgenerational dialogue between the author and her mother, whose stories carry the teachings of her father, the author’s grandfather. …
Retention In A Community College In A Rural State In The Midwest: Factors Associated With Persistence And Withdrawal, Samantha Reeves Grady
Retention In A Community College In A Rural State In The Midwest: Factors Associated With Persistence And Withdrawal, Samantha Reeves Grady
Dissertations and Theses
This qualitative case study examined the factors associated with students’ persistence or withdrawals from courses during the Fall 2025 semester at a community college in the Midwest. Guided by research questions exploring what factors supported students in completing their courses and what prompts course withdrawals. Data was collected through semi-structured interviews and focus groups with students who had withdrawn from one or more courses during the Fall 2025 semester. Using thematic analysis, several key themes emerged. Findings indicated that academic difficulties contributed significantly to student withdrawals. Additionally, course load intensity and competing external factors further hindered student persistence. Students, in …
Meeting The Occupational Needs Of Older Adults With Long-Term Conditions: An Exploration Of Occupational Therapy In Primary Care, Sam Wakley
School of Health Professions Theses
This thesis investigated the occupational needs of older adults with long-term conditions to determine how these needs could be met through primary care, acknowledging this as a contemporary area of occupational therapy practice. Combining three studies offered a comprehensive, occupationally centred analysis of a growing area of practice that remains underexplored. Strand One involved conducting a scoping review to map existing models of primary care for adults with long-term conditions. It demonstrated that current approaches largely neglect occupation, favouring biomedical outcomes and fiscally related priorities. However, growing awareness to quality of life and the role of an integrated multidisciplinary team …
Stimuli Development To Measure Parafoveal Contrast Sensitivity In Age-Related Macular Degeneration At Varying Luminance Levels, Joao Alhada Lourenco
Stimuli Development To Measure Parafoveal Contrast Sensitivity In Age-Related Macular Degeneration At Varying Luminance Levels, Joao Alhada Lourenco
School of Health Professions Theses
Age-related macular degeneration is a common ocular condition in the older adult population, being the leading cause of visual impairments in industrialised countries. The prevalence of age-related macular degeneration is expected to increase along with increased life-expectancy. The early stages of age-related macular degeneration often present no noticeable symptoms; however, visual function may be impaired, particularly under low light conditions. An initial impairment tends to occur in the parafoveal region where rod photoreceptors are denser, as these photoreceptors were shown to be more prone to dysfunction than cone photoreceptors in early stages of age-related macular degeneration. Therefore, testing for this …
The Effects Of Hyperthyroidism On Mouse Corneal Innervation: Implications For Human Cornea Re-Innervation, Anjali Malali
The Effects Of Hyperthyroidism On Mouse Corneal Innervation: Implications For Human Cornea Re-Innervation, Anjali Malali
Research Honors
To test the effects of elevated TH during cornea development, our lab has collaborated with Dr. Juan Davila (University of Illinois Urbana-Champaign) to develop an embryonic mouse model of hyperthyroidism. Embryos were exposed to high levels of TH in utero by adding TH to the pregnant mother’s drinking water. Upon collection of the embryos, elevated blood thyroid levels in the pregnant mother were analyzed with an enzyme-linked immunosorbent assay (ELISA), and eye tissues were collected and preserved for analysis of corneal nerve innervation patterns. By utilizing immunohistochemistry in order to visualize corneal innervation in mouse embryos, this project studied whether …
Music And Mecha: An Analysis Of Mobile Suit Zeta Gundam, Jackson Grey Baker
Music And Mecha: An Analysis Of Mobile Suit Zeta Gundam, Jackson Grey Baker
Research Honors
Music within anime is a topic that has only recently gained traction in terms of academic study in the west. Consequently, there is not a particularly great body of literature yet. Much work has been done regarding the music that introduces the anime and accompanies the closing credits of the show, as these songs often become very popular, sometimes even outside of the anime sphere. But the soundtrack to the show itself is also very important. Within the show there is a large amount of music that connects to the plot, themes, characters, moods and more which greatly affect the …
Monetary Policy And Equity Market Reactions: Linking Monetary Theory To Sector Level Etf Performance, Joseph Freedman
Monetary Policy And Equity Market Reactions: Linking Monetary Theory To Sector Level Etf Performance, Joseph Freedman
Research Honors
This project examines how the economic framework of U.S. monetary policy translates into financial market outcomes by studying sector level equity responses to changes in the Federal Reserve’s effective federal funds rate. While monetary policy theory emphasizes how interest rates influence investment, borrowing costs and risk taking, financial markets reflect these mechanisms through asset prices. Exchange traded funds provide a useful lens for studying this connection, as they aggregate firm level behavior into tradable sector portfolios.
Using daily data from 2004 to 2025, this study analyzes eleven S&P 500 sector exchange traded funds to evaluate how monetary policy shocks are …
“We Only Care For White Germs”: How Black Chicagoans Used Community Care To Overcome Medical Discrimination, Kylie Power
“We Only Care For White Germs”: How Black Chicagoans Used Community Care To Overcome Medical Discrimination, Kylie Power
Research Honors
This project examines the use of Community Care as a means of healthcare within Black American populations, specifically in Chicago. Background information is provided on the evolution of Community Care, from slavery, to post-emancipation, to the early 20th century. Provident Hospital of Chicago in particular is examined during the early 20th century section, with a look at how the 1918 Spanish Influenza affected the Hospital, it's patrons, and Chicago. Important pieces of literature from the time period are combined with newspaper articles and other reports, as well as secondary literature, to construct this social history.
The Development Of Collaborative Relationships Between Disaster Relief Ngos: Barriers And Solutions, Christopher Phillips
The Development Of Collaborative Relationships Between Disaster Relief Ngos: Barriers And Solutions, Christopher Phillips
Plymouth Business School Theses
Collaborative responses amongst disaster relief NGOs can be more effective in delivering aid when compared with responses conducted individually. Collaboration enables the sharing of resources, expertise, personnel, and funding, resulting in more efficient aid distribution in the wake of natural disasters. However, current research highlights that it is often challenging for NGOs to establish and sustain collaborative relationships due to different barriers. The challenges these barriers cause have been explored in previous research, but limited attention has been given with respect to how these can be addressed. Additionally, there is a lack of understanding of the relationships between these barriers, …
The Epidemiology Of Catastrophic Head And Neck Injuries In High School And College Non-Football Sports: A 4-Decade Review, Courtney M. Meyer, Kristen L. Kucera, Samantha E. Scarneo-Miller, Zachary K. Winkelmann, Susan W. Yeargin
The Epidemiology Of Catastrophic Head And Neck Injuries In High School And College Non-Football Sports: A 4-Decade Review, Courtney M. Meyer, Kristen L. Kucera, Samantha E. Scarneo-Miller, Zachary K. Winkelmann, Susan W. Yeargin
Rehabilitation Sciences Faculty Publications
Background:
Catastrophic head and neck injuries (CHNIs) in sport are rare but can have disabling or fatal outcomes. Prior studies have focused on football, equipment-laden sports, or different injury severities, not CHNI in nonfootball sports.
Purpose:
To describe the epidemiology of CHNI across levels (high school vs collegiate) in nonfootball sports and evaluate differences in injury rates (IRs) by sport, sex, and decade.
Study Design
Descriptive epidemiological study.
Methods:
This study utilized 40 academic years (1982-1983 to 2021-2022) of surveillance data from the National Center for Catastrophic Sports Injury Research. Descriptive statistics summarized athlete, event, and injury characteristics. IRs were …
Inside, Outside, And In Between: Black Homeplace As A Blueprint For Privacy Law, Nina-Simone Edwards
Inside, Outside, And In Between: Black Homeplace As A Blueprint For Privacy Law, Nina-Simone Edwards
Library Scholarship
This essay reimagines the meaning of home and privacy for Black Americans by interrogating the legal and technological systems that routinely collapse the sanctity of the homeplace. Using the no-knock warrant as a central case study, this essay illustrates how state-sanctioned intrusions transform a space of rest, memory, and self-making into a site of violence. Although Fourth Amendment doctrine purports to guard against unreasonable searches, its prevailing binary framework–distinguishing only between “inside” and “outside” the home–renders Black domestic spaces uniquely vulnerable. Drawing from Critical Race Theory, particularly its social construction thesis, this essay shows how race, law, and technology co-produce …
Catholic Solidarity In American Jesuit Education Through The Radical Kinship Of Fr. Greg Boyle: A Conceptual Analysis, Sajit U. Kabadi
Catholic Solidarity In American Jesuit Education Through The Radical Kinship Of Fr. Greg Boyle: A Conceptual Analysis, Sajit U. Kabadi
Journal of Catholic Education
This is a conceptual analysis that examines how American Jesuit secondary education can pursue greater Catholic solidarity in a polarized world through a framework of radical kinship, as espoused by Fr. Greg Boyle. Boyle is the founder of Homeboy Industries, the world’s largest gang rehabilitation program, in the city of Los Angeles. The purpose of this conceptual analysis is to delve deeper into Boyle’s conceptual framework of radical kinship in the context of American Jesuit secondary education. This conceptual analysis will use Catholic Social Teaching, Biblical references, and the values of the Jesuit mission.
Language, Gender, And Identity In Immigration Contexts: Pragmatic And Sociocultural Markers In Arabic-Speaking Diaspora Communities, Muhammad Alasmari, Abdu Al-Kadi, Rashad Ahmed, Obied Alaqlobi
Language, Gender, And Identity In Immigration Contexts: Pragmatic And Sociocultural Markers In Arabic-Speaking Diaspora Communities, Muhammad Alasmari, Abdu Al-Kadi, Rashad Ahmed, Obied Alaqlobi
Research, Publications & Creative Work
The pragmatics of native language use among immigrants is a central linguistic concern under the pressures of transnational migration. On this backdrop, this study investigates the multifunctionality of the Arabic expression Aiy Khadamat (AK), a discourse marker widely used by Yemenis in both homeland and diaspora contexts. Focusing on politeness, conflict management, and sociocultural signaling, the study examines how AK functions as a discourse marker within immigrant interactions. A descriptive-analytical design grounded in qualitative methods was employed, using nine discourse completion scenarios presented to 30 male and 30 female Yemeni Arabic speakers residing permanently in the United States. Findings reveal …
A User-Friendly Graphical User Interface For Paw Touch Classification In Rodent Cylinder Testing, Tyler R Johnson, Katherine D Zerefos, Dawn M Taylor
A User-Friendly Graphical User Interface For Paw Touch Classification In Rodent Cylinder Testing, Tyler R Johnson, Katherine D Zerefos, Dawn M Taylor
Faculty, Staff and Student Publications
In unilateral rodent models of disease or injury, deficits are induced in only one side of the body, allowing the difference in right versus left limb usage to serve as a metric of disease/injury severity and recovery with various treatments. Unilateral rat models are commonly used for conditions such as Parkinson’s disease (via the neurotoxin 6-hydroxydopamine, 6-OHDA), stroke, and traumatic brain injury, as well as cervical spinal cord injury and peripheral nerve damage. The ‘cylinder test’ has been used for over two decades as a reliable metric of asymmetry in forelimb usage. In this test, videos are taken of the …
Enhancing Inter-Institutional Ai Research Collaboration Across Multidisciplinary Teams To Increase The National Ai Workforce In Healthcare, Toufeeq Ahmed Syed, Sarah Popal, D'Laney Kernan, Deevakar Rogith, Zulfiia Ditto, Paul Warhurst, Jay Johnson, Jamboor K Vishwanatha
Enhancing Inter-Institutional Ai Research Collaboration Across Multidisciplinary Teams To Increase The National Ai Workforce In Healthcare, Toufeeq Ahmed Syed, Sarah Popal, D'Laney Kernan, Deevakar Rogith, Zulfiia Ditto, Paul Warhurst, Jay Johnson, Jamboor K Vishwanatha
Faculty, Staff and Student Publications
Inter-institutional team collaboration is critical for impactful multidisciplinary AI research in healthcare. The goal of our project (AIM-AHEAD Connect) is to increase multidisciplinary collaborations by connecting AI/ML experts and healthcare researchers, trainees and professionals to enhance research and improve health for all Americans. As of February 2026, AIM-AHEAD Connect has over 10,100 AI/ML and healthcare experts from across 2,400 institutions, has made more than 7,800 connections and facilitated 194 collaborative online groups. We conducted a unique study to understand collaboration, and analyzed profile, connection, and platform engagement metrics to determine if AI experts and healthcare researchers with more inter-institutional connections …
Association Between Three-Dimensional Margin Assessment And Local Tumor Control In Percutaneous Lung Cryoablation Of Colorectal Metastases, Frank Mohn, Koustav Pal, Caleb O'Connor, Iwan Paolucci, Austin Castelo, Kamran Ahrar, Steven Yevich, Joshua D Kuban, Bruno C Odisio, Alda Lui Tam, Rahul A Sheth, Kristy K Brock
Association Between Three-Dimensional Margin Assessment And Local Tumor Control In Percutaneous Lung Cryoablation Of Colorectal Metastases, Frank Mohn, Koustav Pal, Caleb O'Connor, Iwan Paolucci, Austin Castelo, Kamran Ahrar, Steven Yevich, Joshua D Kuban, Bruno C Odisio, Alda Lui Tam, Rahul A Sheth, Kristy K Brock
Faculty, Staff and Student Publications
Purpose
To evaluate the association of two minimum ablation margin (MAM) estimation methods: manual three-dimensional segmentation and biomechanical deformable image registration (DIR) with local tumor progression-free survival (LTPFS) after percutaneous lung cryoablation of colorectal pulmonary metastases.
Materials and Methods
This retrospective single-institution study included patients who underwent percutaneous lung cryoablation between May 2012 and March 2023 (median follow-up, 3.6 years; range, 0.8–9.6 years). Manual three-dimensional MAM was calculated for all tumors, and DIR-based MAM was estimated in a subset with intraprocedural full-thorax imaging. Cox proportional hazards regression assessed associations between MAM and LTPFS. The primary outcome was 2-year LTPFS, with …
Functional, Pharmacogenomic, And Immune Landscapes Of Long Non-Coding Rnas In Cancer, Runhao Wang, Mei Luo, Yuan Liu, Jingwen Yang, Yamei Chen, Chengxuan Chen, Lifei Ma, Stephanie Ding, James Wengler, Yong Zang, Bora Lim, Wenbo Li, Liuqing Yang, Chunru Lin, Lixia Diao, Leng Han
Functional, Pharmacogenomic, And Immune Landscapes Of Long Non-Coding Rnas In Cancer, Runhao Wang, Mei Luo, Yuan Liu, Jingwen Yang, Yamei Chen, Chengxuan Chen, Lifei Ma, Stephanie Ding, James Wengler, Yong Zang, Bora Lim, Wenbo Li, Liuqing Yang, Chunru Lin, Lixia Diao, Leng Han
Faculty, Staff and Student Publications
Long non-coding RNAs (lncRNAs) are emerging as key regulators in cancer, with significant potential as diagnostic, prognostic, and therapeutic targets. Here, this work systematically analyzes lncRNA associations with targeted therapies and immunotherapies across 33 cancer types using The Cancer Genome Atlas (TCGA) and real-world datasets. This work identifies 53,173 lncRNA-pathway associations, millions of lncRNA-drug response associations (via CancerRxTissue and VAEN), and extensive correlations with immune checkpoints and infiltration. This work further identifies 69 lncRNAs associated with immunotherapy response and 2,611 differentially expressed lncRNAs between low and high objective response rate (ORR) groups. Additionally, two lncRNAs are correlated with immune-related adverse …