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Articles 32851 - 32880 of 1518692
Full-Text Articles in Entire DC Network
E-Payment Systems Use: The Role Of Cybersecurity Risk And The Moderating Effect Of Risk Propensity And Technology Readiness, Abdou Illia, Hyunsun Kim-Hahm, Thomas Ngniatedema, Mahaman Sani Yakoubou
E-Payment Systems Use: The Role Of Cybersecurity Risk And The Moderating Effect Of Risk Propensity And Technology Readiness, Abdou Illia, Hyunsun Kim-Hahm, Thomas Ngniatedema, Mahaman Sani Yakoubou
Journal of International Technology and Information Management
Advances in digitalization have accelerated consumer migrations away from traditional cash- and check-based payment systems towards electronic payment systems worldwide. Yet, many people still remain resistant. This study examined the role of motivational and inhibiting factors and their interaction effects on the use of e-payment systems. The findings suggest that perceived cybersecurity risk, risk propensity, trust in the companies offering the e-payment services, and technology readiness have a significant direct impact on the use of e-payment systems. The findings also suggest that risk propensity and technology readiness have a tempering effect on the negative impact of perceived risk. The study …
Business Process Redesign For Reducing Undelivered Product Return Losses In E-Commerce – An Explainable Ai Approach, Venkataraghavan Krishnaswamy, Deepa R, Himanshu Sharma
Business Process Redesign For Reducing Undelivered Product Return Losses In E-Commerce – An Explainable Ai Approach, Venkataraghavan Krishnaswamy, Deepa R, Himanshu Sharma
Journal of International Technology and Information Management
Product returns in e-commerce affect the profitability of the e-tailer. We adopt a two-stage approach to reduce undelivered product returns in an e-commerce firm. First, we develop and compare machine learning techniques—logistic regression, decision trees, Naïve Bayes, random forest, adaptive boosting, gradient boosting, stochastic gradient boosting, and deep neural networks—on their ability to predict undelivered returns. Next, we use explainable methods, such as relative importance and Shapley values, to develop insights from the best-performing machine learning model. Finally, we use these insights and the predictive model to redesign the firm’s order fulfillment and return processes. A Post-implementation evaluation of the …
Pulse Musical Center. The Geometry Of Sound, Luara Sánchez Franco
Pulse Musical Center. The Geometry Of Sound, Luara Sánchez Franco
Grado en Diseño de Interiores
PULSE was created to overturn the exclusivity of Serrano Street, creating a "third space" for musical creation where culture stops being a privilege of consumption and therefore becomes a universal and free right of access. The foundation of a music center at 130 Serrano Street in Madrid, addresses a urban paradox: a high density of young people with a complete lack of freely accessible social infrastructure and space. Located at the heart of a "Student Hub" due to the academic activity of IE University and the CSIC (Spanish National Research Council), the area around the Casa de Villora attracts many …
The 2026 World Cup, In Trump’S Shadow, Richard Holtzman
The 2026 World Cup, In Trump’S Shadow, Richard Holtzman
History, Literature, and the Arts Faculty Journal Articles
This essay examines President Donald Trump’s rhetorical interventions in the lead-up to the 2026 FIFA World Cup. It is inspired by Eduardo Galeano’s Soccer in Sun and Shadow, which interprets football as a mirror reflecting broader political, cultural, and economic realities. My analysis explores how Trump commandeered the World Cup through spectacle, transforming it into a stage for symbolically demonstrating his power and indulging his ego. The president’s rhetorical behavior is explored and critiqued through three case studies and a final vignette: (1) the establishment of a White House World Cup Task Force, (2) the president’s threats to relocate …
College Of Liberal Arts Faculty Bylaws 2026-2027 - Amended 09/2026), College Of Liberal Arts Faculty, Rollins College
College Of Liberal Arts Faculty Bylaws 2026-2027 - Amended 09/2026), College Of Liberal Arts Faculty, Rollins College
College of Liberal Arts Bylaws
No abstract provided.
Treatment Manual For Nonsequential Format Two Part Program For Symptom Self-Management (12 Session Course & Support Group For Booster Dose Of Course), Robin Kay Buccheri, Louise Nigh Trygstad, Martha D. Buffum
Treatment Manual For Nonsequential Format Two Part Program For Symptom Self-Management (12 Session Course & Support Group For Booster Dose Of Course), Robin Kay Buccheri, Louise Nigh Trygstad, Martha D. Buffum
Nursing and Health Professions Faculty Research and Publications
This is the Treatment Manual and 5 Appendices for NonSequential Format. Two-Part Program for Symptom Self-Management of Auditory Hallucinations: 12 Session Course & Support Group for Booster Dose of Course
Winter 2026, Southwestern Oklahoma State University Office Of Institutional Advancement And Alumni
Winter 2026, Southwestern Oklahoma State University Office Of Institutional Advancement And Alumni
Echoes from the Hill
From The Interim President
Fellow members of the SWOSU Community,
I have been grateful for the opportunity to serve Southwestern Oklahoma State University for nearly three decades. As the Spring 2026 semester gets underway, we welcome the opportunity to pause and reflect on what we have learned—and what we continue to achieve together.
The bonds formed among our students, faculty, and staff as we deliver high quality, affordable programs of instruction and training are deep and enduring. The Southwestern Spirit—marked by friendly cooperation, thoughtful inquiry, and hard work—gives SWOSU a distinctive strength and instills in our graduates a lasting sense …
Spring/Summer 2026, Southwestern Oklahoma State University Office Of Institutional Advancement And Alumni
Spring/Summer 2026, Southwestern Oklahoma State University Office Of Institutional Advancement And Alumni
Echoes from the Hill
From The President
SWOSU Community,
SWOSU is 125 years old this year, and 2026 has been an exciting year here on the Hilltop! We are gearing up for a great Fall Semester!
This issue of Echoes highlights the wonderful time we had in the Spring when our students, faculty, and staff joined donors, alumni, dignitaries, and community leaders from throughout Oklahoma and beyond for the dedication of the Jerry & Margaret Hodge Center for Pharmacy & Rural Health. The Center represents an innovative private-public partnership that will enable our university to graduate more healthcare professionals to meet the workforce needs …
Could Have Seen That Coming: New York State Department Of Health Taken To Task For Failing To Provide Proper Oversight Of Medicaid Managed Care Provider Networks, Lance Plunkett Jd, Llm
Could Have Seen That Coming: New York State Department Of Health Taken To Task For Failing To Provide Proper Oversight Of Medicaid Managed Care Provider Networks, Lance Plunkett Jd, Llm
The New York State Dental Journal
A recent audit conducted by the Office of the New York State Comptroller (OSC) found that the New York State Department of Health (NYSDOH) oversight of Medicaid managed care healthcare provider networks was largely illusory and a paperwork sham. This raises the much larger question of whether Medicaid managed care is really serving the population of Medicaid patients. It is already almost a given that it is not serving healthcare providers well.
Single Intratympanic Injection Of Proprietary Brain-Derived Neurotrophic Factor (Oto-413) In Subjects With Speech-In-Noise Hearing Impairment: A Randomized, Dose Escalating, Double-Blind, Placebo-Controlled Phase 1/2 Study, Alan C. Foster, Jeffery J. Anderson, David R. Moore, Morgan Oktela Fuentes, Yiwei Wang, Peter G. Volsky, K. Paul Boyev, Victoria A. Sanchez
Single Intratympanic Injection Of Proprietary Brain-Derived Neurotrophic Factor (Oto-413) In Subjects With Speech-In-Noise Hearing Impairment: A Randomized, Dose Escalating, Double-Blind, Placebo-Controlled Phase 1/2 Study, Alan C. Foster, Jeffery J. Anderson, David R. Moore, Morgan Oktela Fuentes, Yiwei Wang, Peter G. Volsky, K. Paul Boyev, Victoria A. Sanchez
Department of Otolaryngology (ENT) Faculty Publications
Purpose
To evaluate the safety and tolerability and exploratory efficacy of OTO-413, an intratympanic-administered, sustained release formulation of brain-derived neurotrophic factor (BDNF) in a thermoreversible gel, in participants with speech-in-noise hearing difficulties.
Methods
This was a single dose, dose-ascending, randomized, double-blind, Placebo-controlled Phase 1/2 study conducted at 7 enrolling clinical sites in the U.S. 110 participants (56% female) enrolled had self-reported speech-in-noise (SIN) difficulties that were confirmed by a SIN test and were randomized to OTO-413 or Placebo. OTO-413 dose range was escalated from 0.01 mg to 1.5 mg within 7 Cohorts. Safety evaluations included monitoring for treatment-emergent adverse events, …
The Relationship Between Enablement Sentiment And Kpi Achievement, Stefanie Boyer, David E. Fleming, Michael Rodriguez, Tom Tonkin
The Relationship Between Enablement Sentiment And Kpi Achievement, Stefanie Boyer, David E. Fleming, Michael Rodriguez, Tom Tonkin
Marketing Department Faculty Journal Articles
Sales enablement (defined as the "activities, systems, processes and information that support and promote knowledge-based sales interactions with client and prospects” (Gartner, n.d.)) has evolved from a tactical resource to a strategic organizational function, crucial for aligning sales and marketing. Despite its importance, there is a lack of research on how 'sentiment' (perceptions toward enablement) influnces key performance indicators (KPI). This exploratory survey of sales and enablement professionals investigates sentiment across individual, team, and company levels, and its relationship with KPI achievement. Results reveal positive relationships between sentiment and performance outcomes at all levels with organizational sentiment being the strongest …
Deep Joint Source-Channel Coding For Semantic-Aware Adaptive Wireless Image Transmission, Sudipto Das Suvro
Deep Joint Source-Channel Coding For Semantic-Aware Adaptive Wireless Image Transmission, Sudipto Das Suvro
Theses
The growing use of AI-enabled applications has increased the demand for adaptive, efficient, and low-latency image transmission of large data volumes. This has created challenges for conventional separate source-channel coding that focuses on reliable bit sequence transmission without considering the contents or communication objectives. Deep joint source-channel coding (DeepJSCC) potentially solves this by combining source compression and error correction into a unified process. This thesis focuses on developing adaptive and computationally lightweight DeepJSCC-based transceivers for image transmission across heterogeneous channels. The framework further investigates DeepJSCC’s performance in OFDM with robust channel estimation and importance-based subcarrier allocation strategies. Comprehensive evaluation using …
Judge V. Academia, Northern District Of California
Judge V. Academia, Northern District Of California
Historical and Topical Legal Documents
No abstract provided.
Netchoice V. Wilson, District Of South Carolina
Netchoice V. Wilson, District Of South Carolina
Historical and Topical Legal Documents
No abstract provided.
Meeting Tv V. Koi, Southern District Of California
Meeting Tv V. Koi, Southern District Of California
Historical and Topical Legal Documents
No abstract provided.
What Is Hate Speech? A Proposal For An Ordinary And Legal Definition, Hannah Van Dijcke
What Is Hate Speech? A Proposal For An Ordinary And Legal Definition, Hannah Van Dijcke
SJD Dissertations
The term “hate speech” has been stretched in legal and public debates to cover speech ranging from insults to Holocaust denial. This definitional stretching has consequences beyond mere conceptual confusion: it risks obscuring the profound harm that hate speech does, and it facilitates the term’s misuse.
In this dissertation, I aim to precisely define hate speech and its harm, both in an ordinary (colloquial or non-legal) sense and in a legal sense. To do so, I examine real-world examples of speech widely understood to express hate, including texts from the context of the Holocaust and the Rwandan genocide, and conduct …
Bridging The Gap: A Systematic Review Of Cyber Conflict Forecasting Models And The Case For Ai-Driven Dynamic Frameworks, Salim Arfaoui, Youssef Harrath, Omar El-Gayar
Bridging The Gap: A Systematic Review Of Cyber Conflict Forecasting Models And The Case For Ai-Driven Dynamic Frameworks, Salim Arfaoui, Youssef Harrath, Omar El-Gayar
Research & Publications
Cyber conflict forecasting remains constrained by static models that overlook the integration of geopolitical context with technical indicators. This systematic literature review examines 58 studies (2010–2025) using PRISMA guidelines and an Input-Process-Output framework to classify approaches and identify key gaps. Quantitative methods dominate (67%), yet only 14% incorporate geopolitical variables, despite the political nature of cyber conflict. Major limitations include adversarial adaptation blindness (85% assume static behavior), coarse temporal granularity (72% use daily+ intervals), lack of uncertainty quantification (75%), and minimal modeling of cross-domain escalation (92% cyber-only focus). Strategic forecasting is rare, with just 14% providing long-term insights and 16% …
The Explainable Ai Paradox: When Transparency Improves Decision Quality And When It Creates Overconfidence, Harsha Sammangi, Poloju Pravalika
The Explainable Ai Paradox: When Transparency Improves Decision Quality And When It Creates Overconfidence, Harsha Sammangi, Poloju Pravalika
Research & Publications
Explainable artificial intelligence (XAI) is widely promoted as a remedy for algorithmic opacity, premised on the assumption that revealing a model's reasoning improves human oversight and decision quality. This study investigates the Explainable AI Paradox: the possibility that explanations simultaneously increase trust, reliance, and adoption while also producing overconfidence in flawed models — improving decision quality when models are valid but amplifying errors when models are not. Using a controlled experiment with 921 managers making pricing, lending, or inventory decisions assisted by AI systems of deliberately varied validity, participants were randomly assigned to one of five explanation conditions: no explanation, …
A Proposal For Cal Poly Humboldt Spanish Language Family Orientations In Order To Increase First-Gen Latine Student Matriculation And Retention, Xelha B. Puc
Cal Poly Humboldt theses and projects
First-generation college students, defined as those whose parents did not complete a 4-year degree, face distinct challenges when pursuing higher education. Although all first-gen students face significant barriers to success, additional aspects of student identity can further impact their access to institutional support and resources. This project addresses the particular needs of first-generation Latine undergraduate students, who may face additional challenges related to language barriers, limited access to institutional knowledge, financial barriers, and cultural expectations. While existing research highlights the disparities students of this population face, less attention is given to the critical role family support can play in shaping …
Development Of The Core Lit Apparatus For Seaweed Hatcheries (Clash) Bioreactor Using A Germplasm Approach, Phillip O. Tahimic
Development Of The Core Lit Apparatus For Seaweed Hatcheries (Clash) Bioreactor Using A Germplasm Approach, Phillip O. Tahimic
Cal Poly Humboldt theses and projects
In comparison to the Asian aquaculture industry, the United States has minimal seaweed production. There are several drivers of the limited industry in the US, such as regulatory constraints and limited market demand, but the ability to scale is a considerable barrier to commercialization. One possible solution is the development of land-based systems that integrate bioreactors, which utilize fewer resources and do not wholly rely on an oceanic flow-through system. This study assessed the application of a modular bioreactor, known as Core Lit Apparatus for Seaweed Hatcheries (CLASH), as a nursery system and open-source project designed to expand land-based seaweed …
The Effect Of Automated Self-Monitoring On The Behavior Of Individuals Diagnosed With Pre-Diabetes Or Type 2 Diabetes, Leti Phillips Armenta
The Effect Of Automated Self-Monitoring On The Behavior Of Individuals Diagnosed With Pre-Diabetes Or Type 2 Diabetes, Leti Phillips Armenta
Cal Poly Humboldt theses and projects
Type 2 diabetes (T2D) and prediabetes affect millions of individuals in the United States and require effective self-management strategies to reduce glucose variability and improve health outcomes. This study evaluated the effects of automated self-monitoring using the Dexcom G7 continuous glucose monitor (CGM) on glucose management and health-related behaviors among adults diagnosed with prediabetes or at risk for T2D. A repeated-measures design was used to asses’ participants across two distinct 10-day periods. Data included CGM glucose readings, self-report questionnaires, and social validity measures. Results indicated that participants demonstrated reduced glucose variability, fewer prolonged glucose spikes, and increased engagement in health-related …
The Spatial Relationship Between The Residents Of Buttonwillow, Ca And The Carbon Capture And Storage Project, Carbon Terravault, Daniell Dorado
The Spatial Relationship Between The Residents Of Buttonwillow, Ca And The Carbon Capture And Storage Project, Carbon Terravault, Daniell Dorado
Cal Poly Humboldt theses and projects
Carbon capture, utilization and storage (CCUS) is one necessary component in California’s strategy in meeting its carbon neutrality goals. CCUS serves as an important piece to reduce greenhouse gas emissions where other sequestration methods are not yet feasible for certain sectors like electricity generation, cement production and refineries. At the same time, the impacts of industrial projects disproportionately impact underserved communities, and there is a need for more equitable community engagement practices. The state has had an increase in CCUS projects, and several are or will be in Kern County, which has often been a leader in the oil and …
Dextromethorphan And Trace Level Detections Of Dextrorphan In Post-Race Urine Samples – A Case Report And Analysis, Kimberly Brewer, Justin C. Holmes, Clara Fenger, Abelardo Morales-Briceño, Andreas F. Lehner, George A. Maylin, Robert Holland, Levent Dirikolu, Thomas Tobin
Dextromethorphan And Trace Level Detections Of Dextrorphan In Post-Race Urine Samples – A Case Report And Analysis, Kimberly Brewer, Justin C. Holmes, Clara Fenger, Abelardo Morales-Briceño, Andreas F. Lehner, George A. Maylin, Robert Holland, Levent Dirikolu, Thomas Tobin
Maxwell H. Gluck Equine Research Center Faculty Publications
Dextrorphan is a Phase I equine metabolite of dextromethorphan, a widely used anti-tussive / cough suppressant medication marketed and available in numerous over-the-counter formulations in the United States. Dextromethorphan is an Association of Racing Commissioners International (ARCI) drug class 4 penalty class B substance and a Horseracing Integrity and Welfare Authority (HIWU) CONTROLLED S7 B substance and is regulated as such in horse racing. In horses, dextromethorphan is metabolized to its Phase I metabolite, dextrorphan, which is next glucuronidated and the resultant dextrorphan-glucuronide conjugate then excreted at remarkably high concentrations in equine urine. Dextrorphan is therefore at times identified in …
The Association Between Human Papillomavirus Type 16 E6 Seroprevalence And Degrees Of Anal Disease Among Men With Hiv, Krystle A.Lang Kuhs, Christopher Otieno, Staci Sudenga, Tim Waterboer, Weiqun Tong, Dorothy Wiley, Jay H. Bream, Steven Wolinsky, Jeremy Martinson, Gypsyamber D’Souza
The Association Between Human Papillomavirus Type 16 E6 Seroprevalence And Degrees Of Anal Disease Among Men With Hiv, Krystle A.Lang Kuhs, Christopher Otieno, Staci Sudenga, Tim Waterboer, Weiqun Tong, Dorothy Wiley, Jay H. Bream, Steven Wolinsky, Jeremy Martinson, Gypsyamber D’Souza
Epidemiology and Environmental Health Faculty Publications
Introduction: Human papillomavirus type 16 (HPV16) E6 antibodies may be an early biomarker of anal cancer. We cross-sectionally evaluated when in the course of anal disease, HPV16 antibodies are induced. Methods: A nested case-control study of 846 men who have sex with men (MSM) was conducted within a prospective study of men with and without HIV. Cases of anal HPV16 (N=262), biopsy-confirmed high-grade squamous intraepithelial lesion (HSIL;N=140), and anal cancer (N=21) were individually matched to controls (N=423) on HIV status, study-participation duration, and age. Serum samples closest to diagnosis underwent HPV serologic testing; prediagnostic serial samples were tested for anal …
Optimizing Control Definitions In Opioid Use Disorder Genetic Research Using Electronic Health Records, Maria Niarchou, Ellen L Tsai, Mariela V Jennings, Annika Faucon, Hyunjoon Lee, Kritika Singh, Justin D Tubbs, Panos Roussos, Tian Ge, Richard C Crist, Rachel Vickers-Smith, Howard Edenberg, Amy Moore, Bradley T Webb, Eric O Johnson, Rachel L Kember, Jordan W Smoller, Lea K Davis, Brandon J Coombes, Georgios Voloudakis, David Burstein, Travis T Mallard, Vanessa Troiani, Sandra Sanchez-Roige
Optimizing Control Definitions In Opioid Use Disorder Genetic Research Using Electronic Health Records, Maria Niarchou, Ellen L Tsai, Mariela V Jennings, Annika Faucon, Hyunjoon Lee, Kritika Singh, Justin D Tubbs, Panos Roussos, Tian Ge, Richard C Crist, Rachel Vickers-Smith, Howard Edenberg, Amy Moore, Bradley T Webb, Eric O Johnson, Rachel L Kember, Jordan W Smoller, Lea K Davis, Brandon J Coombes, Georgios Voloudakis, David Burstein, Travis T Mallard, Vanessa Troiani, Sandra Sanchez-Roige
Epidemiology and Environmental Health Faculty Publications
Amidst the opioid crisis, understanding the genetic basis of opioid use disorder (OUD) is crucial for identifying biological mechanisms and intervention points. However, genome-wide association studies (GWASs) have been hampered by inadequate sample sizes and often the use of control populations not assessed for prior opioid exposure. Because opioid exposure is a prerequisite for the development of OUD, consideration of exposure history in controls is important. Electronic health record data (EHR) paired with genomic information allow a broader sampling of patients with OUD and exposed controls. We leveraged data across two healthcare systems to evaluate the impact of using controls …
Shaping The Future Of Human Biomonitoring (Hbm), Maryam Zare Jeddi, Nancy B. Hopf, Karen S. Galea, Kate Jones, Henriqueta Louro, Maria João Silva, Adrian Covaci, Tiina Santonen, Paul T.J. Scheepers, Susana Viegas, Lesliam Quirós-Alcalá, Asif Qureshi, M. Elizabeth Marder, Natalie Von Goetz, Konstantinos M. Kasiotis, Kyriaki Machera, Ovnair Sepai, Radu Corneliu Duca, Manosij Ghosh, An Van Nieuwenhuyse, Ming Kei Chung, Jihyon Kil, Shoji F. Nakayama, Aziza Menouni, Kaoutar Chbihi, Ana Maria Vekic, Gustavo Souza, Maisarah Nasution Waras
Shaping The Future Of Human Biomonitoring (Hbm), Maryam Zare Jeddi, Nancy B. Hopf, Karen S. Galea, Kate Jones, Henriqueta Louro, Maria João Silva, Adrian Covaci, Tiina Santonen, Paul T.J. Scheepers, Susana Viegas, Lesliam Quirós-Alcalá, Asif Qureshi, M. Elizabeth Marder, Natalie Von Goetz, Konstantinos M. Kasiotis, Kyriaki Machera, Ovnair Sepai, Radu Corneliu Duca, Manosij Ghosh, An Van Nieuwenhuyse, Ming Kei Chung, Jihyon Kil, Shoji F. Nakayama, Aziza Menouni, Kaoutar Chbihi, Ana Maria Vekic, Gustavo Souza, Maisarah Nasution Waras
Epidemiology and Environmental Health Faculty Publications
Human biomonitoring (HBM) continues to play an indispensable role within exposure science, offering insights into aggregate chemical exposures across populations and life stages. Since 2018, the European chapter of the International Society of Exposure Science Human Biomonitoring Working Group (ISES Europe HBM WG) has aimed to facilitate generation of more and high-quality HBM data. The working group aims to strengthen integration of HBM data into regulatory frameworks through improved study design, harmonized methodologies, and enhanced reporting practices. Key achievements in the past seven years include the harmonization of HBM metadata through development of minimum information requirements for HBM (MIR-HBM), development …
Building The Ryan White Hiv/Aids Program Bench In Kentucky, Lauren Bifulco, Kathleen Harding, Jana Collins, Anna Rogers, Lenon Farkash, Marwan Haddad, Alice Thornton
Building The Ryan White Hiv/Aids Program Bench In Kentucky, Lauren Bifulco, Kathleen Harding, Jana Collins, Anna Rogers, Lenon Farkash, Marwan Haddad, Alice Thornton
Epidemiology and Environmental Health Faculty Publications
The Ryan White HIV/AIDS program (RWHAP) is governed by legislative and programmatic guidelines that ensure comprehensive services are provided to persons with HIV (PWH) across the United States. Comprehensive training and skill building opportunities for programmatic staff are rare. RWHAP funding recipient organizations may struggle to acquire and retain essential program-specific knowledge, with downstream impact on patient care and treatment. We designed a comprehensive 11-session videoconference learning series to improve program staff’s confidence and competence with RWHAP fundamentals. Quantitative pre-vs-post session data were analyzed using Wilcoxon Signed-Rank tests, and qualitative data using thematic analysis. We enrolled 136 staff from 23 …
Decreased Gabapentin Prescription Fills Among Medicaid Enrollees Following State-Level Schedule V Controlled Substance Classification In Kentucky And West Virginia, Katherine Gora Combs, Stephen W. Marshall, Rachel Vickers-Smith, Alan Kinlaw, Nabarun Dasgupta, Juan M. Hincapie-Castillo
Decreased Gabapentin Prescription Fills Among Medicaid Enrollees Following State-Level Schedule V Controlled Substance Classification In Kentucky And West Virginia, Katherine Gora Combs, Stephen W. Marshall, Rachel Vickers-Smith, Alan Kinlaw, Nabarun Dasgupta, Juan M. Hincapie-Castillo
Epidemiology and Environmental Health Faculty Publications
Background: Driven by concerns of gabapentin misuse and other harms, Kentucky (KY) and West Virginia (WV) became the first states to classify gabapentin as a schedule V controlled substance in July 2017 and June 2018, respectively. This study examined the association of these policies with gabapentin utilization among Medicaid beneficiaries. Methods: Using a controlled interrupted time series design, we modeled a segmented generalized least squares regression and calculated the immediate and trend changes of gabapentin prescriptions among Medicaid enrollees in 2 states (KY, WV), separately. North Carolina (NC) was used as a control to account for secular changes; there was …
Metabolic Reprogramming Following Mitochondrial Transfer Between Idh2-Mutant Chondrosarcoma Cells And A Normal B-Cell Line, Caleb Wyckoff, Christopher Osgood, Ellen Jing, Michael Stacey
Metabolic Reprogramming Following Mitochondrial Transfer Between Idh2-Mutant Chondrosarcoma Cells And A Normal B-Cell Line, Caleb Wyckoff, Christopher Osgood, Ellen Jing, Michael Stacey
Bioelectrics Publications
Background/Objectives: Chondrosarcoma, glioblastoma, acute myeloid leukemia, chronic lymphocytic leukemia, and cholangiocarcinoma cancers all contain mutations in the gene isocitrate dehydrogenase 2 (IDH2). The mutant IDH2 enzyme metabolizes alpha-ketoglutarate (αKG) into the potent oncometabolite D-2-hydroxyglutarate (D2HG) in the mitochondria of these cancers, leading to altered cellular metabolism. Emerging evidence suggests that mitochondrial transfer between cancer and recipient cells represents an important form of intercellular communication that may influence cellular metabolism. The presence of intercellular TNTs between IDH2-mutant chondrosarcoma cells motivated an investigation into mitochondria-associated physiological changes occurring during an intercellular exchange with immune cells. A mitochondrial transfer is a two-way …
Identifying Transcriptomic Signatures That Mediate The Causal Effect Of Genotype On Alzheimer's Disease., Simran Kaur, Anna L. Tyler, Giovanna L Durante, Gregory Cary, Gregory W. Carter, J Matthew Mahoney
Identifying Transcriptomic Signatures That Mediate The Causal Effect Of Genotype On Alzheimer's Disease., Simran Kaur, Anna L. Tyler, Giovanna L Durante, Gregory Cary, Gregory W. Carter, J Matthew Mahoney
Faculty Research 2026
The combined effects of thousands of genetic polymorphisms account for Alzheimer's disease (AD) genetic risk. Most AD polymorphisms affect gene expression. Thus, the transcriptome, the set of all gene expression levels for every gene in the genome, is a major mediator between the genotype to phenotype. This study uses genotypes, transcriptomes, and clinical phenotypes to identify the transcriptomic signature that mediates the causal effect of genotype on AD. By utilizing a causal inference method known as high dimensional mediation analysis (HDMA) on the Religious Orders Study/Memory and Aging Project (ROSMAP) longitudinal cohort, the genotype, transcriptome, and phenotype data were reduced …