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Articles 31141 - 31170 of 1517381
Full-Text Articles in Entire DC Network
Africa's Digital Health Revolution: The Digital Fit-Viability Model To Move From Innovation To Scaled Implementation, Afra Jiwa, Antony Ngatia, Karim Benali, Niclas Boehmer, Sangu Delle, Patrick Emedom-Nnamdi, Chris Opoku Fofie, Christine M O'Brien, Tobi Olatunji, Kate Obayabgona, Milind Tambe, Richard Ribon Fletcher, Adeline Adwoa Boatin, Bethany Hedt-Gauthier
Africa's Digital Health Revolution: The Digital Fit-Viability Model To Move From Innovation To Scaled Implementation, Afra Jiwa, Antony Ngatia, Karim Benali, Niclas Boehmer, Sangu Delle, Patrick Emedom-Nnamdi, Chris Opoku Fofie, Christine M O'Brien, Tobi Olatunji, Kate Obayabgona, Milind Tambe, Richard Ribon Fletcher, Adeline Adwoa Boatin, Bethany Hedt-Gauthier
2020-Current year OA Pubs
Digital innovations hold immense potential to transform health care delivery, particularly in sub-Saharan Africa, where financial, geographical, and infrastructural constraints continue to hinder progress toward universal health care delivery. Although a growing health tech sector offers creative solutions, few digital health interventions reach scaled implementation. In this paper, we present the digital fit/viability model-an adapted determinant framework to describe facilitators and barriers to moving from digital tools to integrated digital health implementation. We then use this model to describe the specific challenges and recommended solutions when developing digital health tools for health systems in sub-Saharan Africa.
Diet-Responsive Genetic Determinants Of Intestinal Colonization In The Yeast Candida Albicans, Musfirat Shubaita, Mazen Oneissi, Elena Lindemann-Pérez, Cecilia Fadhel Alvarez, Anne-Marie Krachler, Diana M Proctor, J Christian Pérez
Diet-Responsive Genetic Determinants Of Intestinal Colonization In The Yeast Candida Albicans, Musfirat Shubaita, Mazen Oneissi, Elena Lindemann-Pérez, Cecilia Fadhel Alvarez, Anne-Marie Krachler, Diana M Proctor, J Christian Pérez
Faculty, Staff and Student Publications
Dietary components influence microbial composition in the digestive tract. Although often viewed as energy sources, dietary components are likely to shape microbial determinants of intestinal colonization beyond metabolism. Here, we report that a dietary long-chain fatty acid enhances the yeast Candida albicans colonization of the murine gut partly by eliciting modifications to the fungal cell surface. Mice fed an oleic acid-rich diet were readily colonized by C. albicans and exhibited higher fungal load in feces compared with rodents fed an isocaloric control diet. Surprisingly, β-oxidation, a catabolic process to break down fatty acids for energy production, was dispensable for C. …
The Impact Of Skin Tone On Performance Of Pulse Oximeters Used By Nhs England Covid Oximetry @Home Scheme: Measurement And Diagnostic Accuracy Study, Exakt Study Investigators, Daniel S Martin, James C Doidge, Doug Gould, Tasnin Shahid, Alex Cowden, Walton N Charles, Amelia Francis Johnson, Roger Garrett, Catherine Mbema, Olusegun Olusanya, Eugene Healy, Kathryn Rowan, Paul Mouncey, David A Harrison
The Impact Of Skin Tone On Performance Of Pulse Oximeters Used By Nhs England Covid Oximetry @Home Scheme: Measurement And Diagnostic Accuracy Study, Exakt Study Investigators, Daniel S Martin, James C Doidge, Doug Gould, Tasnin Shahid, Alex Cowden, Walton N Charles, Amelia Francis Johnson, Roger Garrett, Catherine Mbema, Olusegun Olusanya, Eugene Healy, Kathryn Rowan, Paul Mouncey, David A Harrison
Peninsula Medical School
OBJECTIVES: To assess the impact of skin tone on the measurement and diagnostic accuracy of five fingertip pulse oximeters used by patients in the NHS (National Health Service) England COVID Oximetry @home scheme.
DESIGN: Measurement and diagnostic accuracy study (exploring pulse oximeter accuracy across skin tones-EXAKT).
SETTING: Twenty four intensive care units in England between June 2022 and August 2024.
PARTICIPANTS: 903 critically ill adults admitted to intensive care units screened for or enrolled into a trial evaluating different approaches to oxygen therapy.
INTERVENTIONS: Pulse oximetry derived peripheral oxygen saturation (SpO2) measurements were compared with paired arterial oxygen saturation (SaO2) …
Lefferts Ave. Ventures Llc V. Keennlyside
Lefferts Ave. Ventures Llc V. Keennlyside
All Decisions
The court addressed a tenant's motion to dismiss a landlord's action for unpaid rent arrears, arguing a three-year statute of limitations for consumer credit transactions under CPLR 214-i. The tenant contended that unpaid rent constituted a consumer credit transaction. The court, however, rejected this argument, distinguishing it from consumer debt under the FDCPA. It ruled that failure to pay rent is a breach of a lease agreement, subject to a six-year statute of limitations for breach of contract, not a consumer credit transaction. Therefore, the tenant's motion to dismiss was denied, allowing the landlord's claim to proceed.
Unlocking The Benefits Of Transparent And Reusable Science For Climate Risk Management, Adam B. Pollack, Lisa Auermuller, Casey D. Burleyson, Jentry Campbell, Madison Condon, Courtney Cooper, Matteo Coronese, Sönke Dangendorf, James Doss-Gollin, Prabhat Hegde, Casey Helgeson, Robert E. Kopp, Jan Kwakkel, Corey Lesk, Justin Mankin, Robert E. Nicholas, Jennie Rice, Samantha Roth, Vivek Srikrishnan, Moira Scheeler, Nancy Tuana, Chris Vernon, Mengqi Zhao, Klaus Keller
Unlocking The Benefits Of Transparent And Reusable Science For Climate Risk Management, Adam B. Pollack, Lisa Auermuller, Casey D. Burleyson, Jentry Campbell, Madison Condon, Courtney Cooper, Matteo Coronese, Sönke Dangendorf, James Doss-Gollin, Prabhat Hegde, Casey Helgeson, Robert E. Kopp, Jan Kwakkel, Corey Lesk, Justin Mankin, Robert E. Nicholas, Jennie Rice, Samantha Roth, Vivek Srikrishnan, Moira Scheeler, Nancy Tuana, Chris Vernon, Mengqi Zhao, Klaus Keller
Faculty Scholarship
People around the world seek climate risk information to guide their decisions. For instance, projections about future flood risk inform where households choose to live, how lenders manage credit risks, and which communities receive federal funding. Yet data limitations and fundamental validation challenges raise important concerns about the reliability of such projections. The principles of transparency and reusability help address these concerns by enabling scrutiny of assumptions and methods, development of foundational data and tools, and consistent application of evaluation standards. While there is ongoing debate about how much transparency commercial climate risk services should provide, many expect noncommercial actors …
Real-World Multicenter Assessment Of Sustained Clinical Outcomes After Digital Deep Brain Stimulation, Alireza Gharabaghi, Sergiu Groppa, Elena Casas, Alfons Schnitzler, Laura Muñoz-Delgado, Vicky L. Marshall, Jessica Karl, Lin Zhang, Ramiro Alvarez, Mary S. Feldman, Michael J. Soileau, Lan Luo, Benjamin L. Walter, Chengyuan Wu, Hong Lei, Damian M. Herz, Devyani Nanduri, Claudia A. Salazar, Corneliu Luca, Daniel Weiss
Real-World Multicenter Assessment Of Sustained Clinical Outcomes After Digital Deep Brain Stimulation, Alireza Gharabaghi, Sergiu Groppa, Elena Casas, Alfons Schnitzler, Laura Muñoz-Delgado, Vicky L. Marshall, Jessica Karl, Lin Zhang, Ramiro Alvarez, Mary S. Feldman, Michael J. Soileau, Lan Luo, Benjamin L. Walter, Chengyuan Wu, Hong Lei, Damian M. Herz, Devyani Nanduri, Claudia A. Salazar, Corneliu Luca, Daniel Weiss
Department of Neurosurgery Faculty Papers
Remote, internet-based deep brain stimulation programming for Parkinson's disease accelerates clinical benefits postoperatively by improving access to therapy adjustments compared to in-clinic optimization. After completion of the initial digital programming phase, we show that clinical outcomes, quality of life, and safety remain sustained over at least twelve months under routine care conditions. Embedding a randomized trial within a larger cohort study enables long-term, real-world evaluation, offering a scalable and pragmatic model for assessing complex digital interventions in routine clinical care. (NCT05269862 registered on 2022-03-08 and NCT04071847 registered on 2019-08-28).
Resilient Leadership In Action: The Rhetoric And Relationships Of Abraham Lincoln For Today’S Public Administration, Wayne Morris Baker
Resilient Leadership In Action: The Rhetoric And Relationships Of Abraham Lincoln For Today’S Public Administration, Wayne Morris Baker
Doctoral Dissertations and Projects
Public administration faces growing volatility and complexity, requiring leadership models that extend beyond traditional management paradigms. This qualitative, historical-explanatory case study introduces and tests a multidimensional theory of resilient leadership in public administration through the rhetoric and relationships of Abraham Lincoln during his presidency. Guided by one central and four sub-research questions, the study analyzes fifty-six of Lincoln’s letters, speeches, and memoranda alongside fifteen diary entries by Navy Secretary Gideon Welles. Using a dual framework that integrates the Four-Factor Leadership Model and the proposed five-dimensional resilient leadership model: adaptability and learning, ethical decision-making and integrity, collaborative governance and stakeholder engagement, …
Jesus’S View On Church Unity And Leadership: A Comparative Study Of His Views Against The Old Testament And Pauline Models In Addressing Leadership-Driven Divisions Within The Togolese Assemblies Of God Church, Sidibé-Néwendé Kamassé
Jesus’S View On Church Unity And Leadership: A Comparative Study Of His Views Against The Old Testament And Pauline Models In Addressing Leadership-Driven Divisions Within The Togolese Assemblies Of God Church, Sidibé-Néwendé Kamassé
Doctoral Dissertations and Projects
This paper will analyze the lack of alignment between Jesus's view of kingdom-centered unity and the pattern of leadership, and how these differences have affected the rule of the church according to biblical history. The paper further examines the problem of divisions driven by leadership in the modern churches, especially those in the Togolese Assemblies of God Church (TAGC). The thesis argues that Jesus's unique teachings on the Kingdom of God can be viewed as both the key organizational principle defining ecclesial leadership and unity and the final leadership paradigm that wrestles with the Old Testament and Pauline models of …
African American Adult Male Survivors Of Childhood Sexual Abuse And Their Subsequent Experiences In Intimate Partner Relationships, Christian Lee Jefferson
African American Adult Male Survivors Of Childhood Sexual Abuse And Their Subsequent Experiences In Intimate Partner Relationships, Christian Lee Jefferson
Doctoral Dissertations and Projects
The purpose of this qualitative interpretive phenomenology study is to explore the lived experiences of African American adult male survivors of childhood sexual abuse within intimate partner relationships. The problem is that it is not known how African American adult male survivors of childhood sexual abuse describe their present or past intimate partner relationships experience or the impact that childhood sexual abuse has on their intimate partner relationships. Research shows how experiences of sexual abuse create difficulty in managing intimate partner relationships. Many survivors of childhood sexual abuse often had damaging effects on adults with their romantic relationships. Findings from …
A Phenomenological Study To Describe The Lived Experiences Of U.S. Military Veterans Diagnosed With Ptsd Who Have Completed A Spiritually Integrated Treatment Program, Roger Fall
Doctoral Dissertations and Projects
The purpose of this phenomenological study was to describe the lived experiences of U.S. military veterans diagnosed with post-traumatic stress disorder (PTSD) who completed a spiritually integrated treatment program. Schlossberg’s transition theory formed the study’s primary theoretical framework, through which the following research questions were answered: 1) How do U.S. military veterans diagnosed with PTSD describe their experiences before attending a spiritually integrated treatment program? 2) How do the participants describe their expectations for the program prior to their participation? 3) How were the participants’ expectations met, and were any unexpected outcomes experienced while participating in the program? and 4) …
Social Support In The College Classroom And The Impact Supportive Communication Has On Student Academic Success And Quality Of Life, Rachael Tiede
Social Support In The College Classroom And The Impact Supportive Communication Has On Student Academic Success And Quality Of Life, Rachael Tiede
Doctoral Dissertations and Projects
College students often encounter academic and personal challenges that lead to stress, anxiety, and feelings of isolation. These challenges can feel burdensome, making it difficult for them to determine the best course of action for the issues they face. They frequently experience difficulties in managing the demands of college. Given these challenges, a potential solution for their anxiety and stress is social support through supportive communication from friends, instructors, and others at the college or university. Guided by social support theory and social penetration theory and employing a quantitative methodology, the research examined the impact of supportive communication on college …
Unmothered: A Phenomenological Study Of Black Daughters Who Are Detached From Their Black Mothers, Imani S. Steele
Unmothered: A Phenomenological Study Of Black Daughters Who Are Detached From Their Black Mothers, Imani S. Steele
Doctoral Dissertations and Projects
Mother-daughter relationships are often characterized as foundational, nurturing bonds, but for some adult daughters, the relationship is a source of pain and disconnection. This phenomenological study explored the lived experiences of adult Black American daughters who are detached from their Black American mothers, influenced by Bowen Family Systems Theory’s emotional cutoff concept. Seventeen Black adult women, aged 27-49, were interviewed to assess how they made meaning of being detached from their mothers, along with the ways it shaped their lives. Findings showed that detachment was a gradual response to a history of harmful mothering. Daughters described detachment as an act …
Perceptions Of Defund The Police, Russell F. Cooper
Perceptions Of Defund The Police, Russell F. Cooper
Doctoral Dissertations and Projects
This research delves into contemporary literature on the Defund the Police movement in the United States, a significant force shaping law enforcement practices and the future landscape of policing and criminal justice. Stemming from the aftermath of the 2020 George Floyd protests, this movement has spurred transformations in policing methodologies and resource distribution. With its expansion across the nation, law enforcement agencies are grappling with high turnover rates and a dwindling pool of qualified applicants. The Defund the Police movement, originally aimed at abolishing police departments due to perceived systemic issues, underscores the need for progressive law enforcement reforms, particularly …
The Effect Of Parent-Child Relationship, Teacher-Student Relationship, And Parent/Teacher Religiosity On Prosocial Behavior In Early Childhood, Monifa Andrea Cross
The Effect Of Parent-Child Relationship, Teacher-Student Relationship, And Parent/Teacher Religiosity On Prosocial Behavior In Early Childhood, Monifa Andrea Cross
Doctoral Dissertations and Projects
There are several factors that can influence prosocial development in early childhood, including secure attachments, perspective-taking skills, empathy, parent-child relationships, teacher-student relationships, and parent/teacher religiosity. The purpose of this qualitative collective case study was to explore how parent–child relationships, teacher–student relationships, and the religiosity of both parents and teachers are perceived to influence prosocial behavior in 5- to 6-year-old children in early childhood settings. Through an in-depth examination of multiple cases, this study aimed to understand the lived experiences and perspectives of parents and teachers regarding the relational and spiritual factors that may support or shape prosocial development during this …
A Qualitative Exploration Of Global Remote Leadership, Melissa Morrison
A Qualitative Exploration Of Global Remote Leadership, Melissa Morrison
Doctoral Dissertations and Projects
Leaders of organizations have faced many changes with respect to remote work. As face-to-face interactions decrease, the opportunities and challenges of technological and digital advancement further the complexity of remote work. Leaders serve as prominent figures who use remote technology to communicate and interact with employees that report to them. The relationship between remote work and the development of meaningful social interactions remains largely unexplored (Clark et al., 2018). This phenomenological study explored the described experiences of remote leaders, the role that identity development plays in the success of leadership remote work, how their identity development impacts their well-being and …
Espionage, Civil Liberties, And The Secret War Of The American Revolution, Jackson Tomlin
Espionage, Civil Liberties, And The Secret War Of The American Revolution, Jackson Tomlin
Doctoral Dissertations and Projects
This dissertation attempts to analyze the line between a government that can create security for its constituents, while also protecting their rights. It is an attempt to understand this schism by looking at the American Revolution and the role of spying in all of it. It aims to establish the role of spying in this narrative by first looking at the role of espionage in the ranks of the British government. The research attempts to look at how spying affected the American Revolution, how colonists lost their civil liberties because of spying, and the how spying played a future role …
Examining The Intergenerational And Transgenerational Impact Of Military-Related Posttraumatic Stress Disorder On Academic Success In College Students In The United States, Kimberlee Bazo
Doctoral Dissertations and Projects
Military families and caregivers have unique experiences with their service member which can both enhance and challenge their daily lives. The purpose of this dissertation was to examine the transgenerational and intergenerational impact of military-related posttraumatic stress disorder (PTSD) on academic success in college students in the United States. This non-experimental, quantitative research design utilized both descriptive and correlational data analysis. Self-report measures and grade point average (GPA) provided the data from a total of 67 participants, as determined by an a priori analysis, for the results and subsequent discussion sections. Participants were recruited through a variety of sources using …
A Phenomenological Study Exploring Christian Women Emotional Traumatic Symptoms Post Spousal Infidelity, Tracy Y. Davis
A Phenomenological Study Exploring Christian Women Emotional Traumatic Symptoms Post Spousal Infidelity, Tracy Y. Davis
Doctoral Dissertations and Projects
The discovery of spousal infidelity has been recognized in the literature as a devastating breach of marital commitment. The purpose of this phenomenological study was to describe women of faith’s experiences with emotional trauma after discovering spousal infidelity in the Northeastern United States. This study’s theoretical framework is guided by Schlossberg’s transition theory, which aims to answer the following research questions: How do women of faith describe emotional trauma after the discovery of infidelity? How does infidelity affect the psychological, emotional, and physical functioning of women and their social systems? How do participants describe their spiritual relationship with God after …
Evaluating Theories On End-Of-Life Dreams And Visions With Similar Phenomena In Trauma-Related Populations, Christopher Channy Vinson
Evaluating Theories On End-Of-Life Dreams And Visions With Similar Phenomena In Trauma-Related Populations, Christopher Channy Vinson
Doctoral Dissertations and Projects
A grounded theory approach was used to conduct a study on participants (N=24) who were veterans with trauma-related dreams or who had a near-death experience. Research questions were designed to qualitatively examine the lived experiences of dreams and visions in a non-end-of-life setting. This allowed the data to give greater insight into the end-of-life phenomenon and deepen the body of knowledge on dreams and visions in general. A survey consisting of the PTGI-SF, LuCiD, NExS, and the Greyson NDE, along with open-ended survey questions designed to record dream narratives for a thematic analysis, was used. The dream narratives were coded …
Exploring The Counselor Identities Of Latina Counselors Through The Lens Of Their Familial, Cultural, And Religious Contexts: A Phenomenological Study, Samuel Landa
Doctoral Dissertations and Projects
Developing a counselor identity is an essential component of becoming a counselor. There are several factors influencing the developmental process. Though there are several studies that explore the topic of counselor identity development, the research on what this process entails for Latina counselors is limited. Thus, this transcendental phenomenological qualitative study explores how family, culture, and religion influence the counselor identity development of Latina counselors. This study utilized Schlossberg’s transition theory (1981) to observe how these factors become evident in the first year of their Council for Accreditation of Counseling and Related Educational Program (CACREP) and how they influenced their …
Examining Perceived Problem-Solving Skills, Parenting Styles, And Biblical Principles: Insights From Parents Or Guardians Of African American Teen Males, Dorothy Farrow
Doctoral Dissertations and Projects
This quantitative study examined the relationship among parenting styles, the use of biblical principles in parenting, and the problem-solving skills of African American male teenagers aged 14 to 17 years in Cuyahoga County, Ohio, as perceived by their parents or guardians. The study addressed a significant gap in existing literature by integrating biblical teachings with established psychological theories on parenting. The primary theoretical frameworks included Baumrind's parenting styles theory and Bandura's social cognitive theory. Using the Kruskal–Wallis H and chi-square tests, the study assessed the potential relationships among parenting styles, biblical use in parenting, and parent-perceived problem-solving skills of their …
Officers On Patrol: Perspectives Of An Arrest On Past And Present Law Enforcement Officers, Shanee N. Ellington
Officers On Patrol: Perspectives Of An Arrest On Past And Present Law Enforcement Officers, Shanee N. Ellington
Doctoral Dissertations and Projects
While attempting to apprehend suspects, police officers must contend with complex obstacles arising from the arrest's legal, ethical, and sociopolitical context. Officers had to follow their department’s guidelines while also developing legal procedures when carrying out an arrest. The study focused on how an officer’s perception of arrest decisions and procedures encapsulated challenges and ethical dilemmas. Through a semi-structured interview with twenty respondents, this research explored the implications of arresting behaviors on officers’ professional identity formation and development. The data analysis followed the grounded theory approach, which focused on identifying differences and similarities between former and current officers over time. …
Prevalence Of Intimacy Satisfaction In Relation To Burnout And Trauma Saturation Of First Responders, Krystoffer L. Bowman
Prevalence Of Intimacy Satisfaction In Relation To Burnout And Trauma Saturation Of First Responders, Krystoffer L. Bowman
Doctoral Dissertations and Projects
A shared understanding of this issue enables us to recognize the uniqueness of each individual’s experience, supported by the consistent commitment of trauma-saturated professionals. But what happens when these individuals become so accustomed to trauma that they can no longer recognize it as such? When their professional identity is inherently tied to continuous exposure to trauma, they may unconsciously adopt emotional distancing as a coping mechanism, which can appear to others as a fixed personality trait or lifestyle, even outside the workplace. This professional emotional distancing, often a consequence of growing burnout and trauma saturation, may negatively impact intimacy satisfaction. …
A Phenomenological Study Of The Personal And Professional Experiences Of U.S. Police Leaders Who Led Their Agency Through A Line-Of-Duty Death, Elizabeth A. Cary
A Phenomenological Study Of The Personal And Professional Experiences Of U.S. Police Leaders Who Led Their Agency Through A Line-Of-Duty Death, Elizabeth A. Cary
Doctoral Dissertations and Projects
The purpose of this phenomenological study was to describe the personal and professional experiences of police leaders from across the United States who led their agencies through line-of-duty deaths (LODD). The social constructivist worldview guided this study as Creswell and Poth (2025) suggest that it captures complicated and multifaceted subjective meanings of individuals. Transformational leadership theory was the lens through which this research was conducted. Police leaders are faced with personnel, political, societal, and generational challenges following the events of Ferguson, George Floyd, the COVID-19 pandemic. This is on top of the already stressful and traumatic work police officers face …
Trauma-Informed Practices (Tips) And Burnout, Job Satisfaction, And Ptsd In First Responders, Tyler Mcdonough
Trauma-Informed Practices (Tips) And Burnout, Job Satisfaction, And Ptsd In First Responders, Tyler Mcdonough
Doctoral Dissertations and Projects
First responders are the frontline defense of society and consist of people that push back against chaos to keep our communities civilized and in functioning order. This study aimed to ensure that first responders’ mental health is adequate for home life as well as daily job functions, and to assess which Trauma Informed Practices (TIPs) can lead to positive outcomes in reducing first responder’s feelings of burnout, increasing their job satisfaction, and suppressing frequency of PTSD symptoms. TIPs are different intervention techniques that are designed to assist the individual with a variety of emotions such as anxiety, stress, burnout, and …
Vocal Strain In General Music Educators: Choral Vs. Instrumental Training, Jennifer Mclean Stadelmeyer
Vocal Strain In General Music Educators: Choral Vs. Instrumental Training, Jennifer Mclean Stadelmeyer
Doctoral Dissertations and Projects
Elementary general music educators are at high risk for vocal strain due to the continuous demands of speaking, singing, and classroom management throughout the school day. Prolonged vocal strain can result in voice loss, vocal cord damage, and hoarseness. While the issue of vocal health in educators is widely acknowledged, limited research examined the specific factors contributing to vocal strain among general music educators, particularly in relation to their training backgrounds. This quantitative, causal-comparative study investigated the difference in vocal strain between choral-trained and instrumental-trained music educators teaching elementary general music. Participants included elementary general music educators (N = 12) …
Assessing Pediatric Providers' Physical Activity Counseling Practices And The Feasibility Of Establishing An Exercise Referral Pathway, Kiara Robins
Doctorate in Kinesiology
Pediatric obesity and physical inactivity remain significant public health concerns, yet many pediatric providers report limited training, time, and resources to deliver effective physical activity counseling. The purpose of this pilot study was to examine pediatric providers’ familiarity with physical activity guidelines, confidence in counseling, perceived barriers, and attitudes towards integrating exercise professionals into pediatric care in Eastern North Carolina. A secondary aim evaluated the feasibility of engaging regional practices using a structured recruitment strategy. Eleven pediatric healthcare providers completed an online survey assessing demographic characteristics, counseling behaviors, and perception of a proposed exercise referral model. Providers reported moderate to …
Livestreaming A Doitocracy: Platform-Jumping Participatory Practices In Modular Synthesis Gear Cultures, Eliot Bates
Livestreaming A Doitocracy: Platform-Jumping Participatory Practices In Modular Synthesis Gear Cultures, Eliot Bates
Publications and Research
Earth Modular Society (EMS) is a cross-platform community dedicated to live hardware modular synthesis, with their primary efforts going into a 24/7 modular “radio station” that livestreams on Twitch and YouTube, and a supporting Discord chat server. Although part of the broader modular synthesis gear culture (a large-scale social formation that coalesces around specific classes of fetishized technical objects), EMS represents a new development in gear cultures as it foregrounds live performance and minimizes the accrual of status via conspicuous consumption. The normative governance structures of platform-specific gear culture communities preclude all but one or a handful of users from …
Egfr Inhibitor-Resistant Lung Cancers Exhibit Collateral Sensitivity To A Covalent, Cysteine-Independent Keap1 Oligomerizing Molecular Bridge, Christopher F Bassil, Kerry Dillon, Gray R Anderson, Benjamin Mayro, Kayleigh N Askin, Peter S Winter, Stefan Harry, Samuel Gruber, Tierney M Hall, Jacob P Hoj, Christian Cerda-Smith, Haley M Hutchinson, Shane T Killarney, Ava Heffernan, Caroline Teddy, Katherine R Singleton, Li Qin, Kévin Jubien-Girard, Cécile Favreau, Guillaume Robert, Barr Tivon, Ella Livnah, Nir London, Rachid Benhida, Patrick Auberger, Ann Marie Pendergast, Liron Bar-Peled, David M Lonard, Anthony R Martin, Alexandre Puissant, Kris C Wood
Egfr Inhibitor-Resistant Lung Cancers Exhibit Collateral Sensitivity To A Covalent, Cysteine-Independent Keap1 Oligomerizing Molecular Bridge, Christopher F Bassil, Kerry Dillon, Gray R Anderson, Benjamin Mayro, Kayleigh N Askin, Peter S Winter, Stefan Harry, Samuel Gruber, Tierney M Hall, Jacob P Hoj, Christian Cerda-Smith, Haley M Hutchinson, Shane T Killarney, Ava Heffernan, Caroline Teddy, Katherine R Singleton, Li Qin, Kévin Jubien-Girard, Cécile Favreau, Guillaume Robert, Barr Tivon, Ella Livnah, Nir London, Rachid Benhida, Patrick Auberger, Ann Marie Pendergast, Liron Bar-Peled, David M Lonard, Anthony R Martin, Alexandre Puissant, Kris C Wood
Faculty, Staff and Students Publications
Targeted therapies have revolutionized cancer care. Unfortunately, most patients develop refractory, multifocal resistance to these therapies within a matter of months. Here, we demonstrate that the evolution of resistance to EGFR inhibitors in EGFR-mutant non-small cell lung cancer endows cells with hypersensitivity to a PAINS-like small molecule, MCB-613. Systematic proteomic, functional genomic, and biochemical studies revealed that MCB-613 binds KEAP1 in a covalent, cysteine-independent fashion, acting as a divalent molecular bridge that relies upon lysine residues in the KEAP1 dimerization domain to join monomers of KEAP1 together. Oligomerization of KEAP1 by MCB-613 sets into motion a fatal cascade of KEAP1 …