Digital Commons Network^™

Tribbles 2 Pseudokinase Confers Enzalutamide Resistance In Prostate Cancer By Promoting Lineage Plasticity, Jitender Monga, Indra Adrianto, Craig G. Rogers, Shirish M. Gadgeel, Dhananjay A. Chitale, Joshi J. Alumkal, Himisha Beltran, Amina Zoubeidi, Jagadananda Ghosh

Urology Articles

Enzalutamide, a second-generation antiandrogen, is commonly prescribed for the therapy of advanced prostate cancer, but enzalutamide-resistant, lethal, or incurable disease invariably develops. To understand the molecular mechanism(s) behind enzalutamide resistance, here, we comprehensively analyzed a range of prostate tumors and clinically relevant models by gene expression array, immunohistochemistry, and Western blot, which revealed that enzalutamide-resistant prostate cancer cells and tumors overexpress the pseudokinase, Tribbles 2 (TRIB2). Inhibition of TRIB2 decreases the viability of enzalutamide-resistant prostate cancer cells, suggesting a critical role of TRIB2 in these cells. Moreover, the overexpression of TRIB2 confers resistance in prostate cancer cells to clinically relevant …

Stress Classification Using Deep Learning With 1d Convolutional Neural Networks, Abdulrazak Yahya Saleh, Lau Khai Xian

Knowledge Engineering and Data Science

Stress has been a major problem impacting people in various ways, and it gets serious every day. Identifying whether someone is suffering from stress is crucial before it becomes a severe illness. Artificial Intelligence (AI) interprets external data, learns from such data, and uses the learning to achieve specific goals and tasks. Deep Learning (DL) has created an impact in the field of Artificial Intelligence as it can perform tasks with high accuracy. Therefore, the primary purpose of this paper is to evaluate the performance of 1D Convolutional Neural Networks (1D CNNs) for stress classification. A Psychophysiological stress (PS) dataset …

A Framework Of Web-Based Dark Patterns That Can Be Detected Manually Or Automatically, Ioannis Stavrakakis, Andrea Curley, Dympna O'Sullivan, Damian Gordon, Brendan Tierney

Articles

This research explores the design and development of a framework for the detection of Dark Patterns, which are a series of user interface tricks that manipulate users into actions that they do not intend to do, for example, share more data than they want to, or spend more money than they plan to. The interface does this using either deception or other psychological nudges. User Interface experts have categorized a number of these tricks that are commonly used and have called them Dark Patterns. They are typically varied in their form and what they do, and the goal of this …

Single-Cell Analysis Of Aneurysmal Aortic Tissue In Patients With Marfan Syndrome Reveals Dysfunctional Tgf-Β Signaling, Ashley Dawson, Yanming Li, Yang Li, Pingping Ren, Hernan G. Vasquez, Chen Zhang, Kimberly R. Rebello, Waleed Ageedi, Alon R. Azares, Aladdein Burchett Mattar, Mary Burchett Sheppard, Hong S. Lu, Joseph S. Coselli, Lisa A. Cassis, Alan Daugherty, Ying H. Shen, Scott A. Lemaire

Saha Cardiovascular Research Center Faculty Publications

The molecular and cellular processes leading to aortic aneurysm development in Marfan syndrome (MFS) remain poorly understood. In this study, we examined the changes of aortic cell populations and gene expression in MFS by performing single-cell RNA sequencing (scRNA seq) on ascending aortic aneurysm tissues from patients with MFS (n = 3) and age-matched non-aneurysmal control tissues from cardiac donors and recipients (n = 4). The expression of key molecules was confirmed by immunostaining. We detected diverse populations of smooth muscle cells (SMCs), fibroblasts, and endothelial cells (ECs) in the aortic wall. Aortic tissues from MFS showed alterations …

The Reality Of Psychological Defense Deception Among Students Practicing Sports In The Faculties Of Physical Education And Sports Sciences/Baghdad University, Sawsan Jawdat, Najlaa Abbas

Modern Sport

The study aimed to apply the measure of psychological defense deception for university students practices for sports, and to recognize the level of psychological defense deception among university students practices for sports, and the researchers adopted the descriptive curriculum by the survey method a sample of third-graders in the Faculties of Physical Education and Sports Sciences /Baghdad University for the academic year (2020-2021) and the number of the students are (209) students, selected from them (189) students by (90.43%) In the random way of the main application sample, also (10) students were selected by (4,785%) in a random way of …

The Reality Of The Cognitive Burden Of The Methods Of Teaching Physical Education For Male And Female Teachers Of Al-Karkh Al-Thania Education Directorate, Fatima Naeem

Modern Sport

The aim of the research is to build a cognitive load scale for the methods of teaching physical education for male and female teachers of the eduction for male and female teachers of the second karkh Education Directorate , and to identify the details of the leval of cognitive burden for the methods of teaching physical education forthem . Baghdad Al - Karkh /2 numbering (59) individuals , all of them were chosen deliberately at a rate of (100%) , and then they wrer divded into three samples ( contruction , exploratory and application ) according to the requirements of …

Spatial Analysis Of Infrastructure Services In Samawah City For The Year 2019, Shaima Talib Kazim Sandil, Maher Nasser Abdullah

Uruk Journal of Human Sciences

The increase in population in urban cities, especially in developing cities, has increased the demand for services, especially infrastructure services, as the research aims to spatially analyze infrastructure services, which included (water, electricity, sewage, communications, roads and bridges) and their spatial distribution and the extent of their efficiency and adequacy, and the study relied on the Descriptive, analytical and statistical method with the help of field study and personal interviews in order to explain and analyze the study problem, as well as using a number of maps and tables, and among the The most important results that the research has …

The Geopolitical Significance Of The Port Of Gwadar Challenges And Future Visions, Vian Ahmed Mohamed

Uruk Journal of Human Sciences

The port of Gwadar is a major turning point in the Pakistani economy, as it is characterized by a very important strategic location and has characteristics that enable it to play an active role in the region, being a land bridge linking Central Asia, especially the countries of Central and South Asia, by the sea, and also linking the Chinese economy (west of China to the port). And due to its distinguished strategic location, which made it a center of attraction for large commercial ships, despite all the positive advantages, there are obstacles that stand in the way of completing …

Media Stylistics Linguistic Representation, Realization, And Perception, Hussein Huwail Ghayadh

Uruk Journal of Human Sciences

Communication can be accomplished through the processes of encoding (developing and sending messages) and decoding (turning messages into thoughts). Communication generally manifests itself within the perspective of some social situation which is responsible for setting the context for the conveyed interlocutors’ intentions. This paper looks at how the messages are encoded by the interviewee, how his linguistic choices are stylistically and constructive, and how his arguments are logically arranged. Not only the interviewee’s task, but this paper also detects how the audience perceives the intentions, how they match the linguistic choices with their referents (semantic or pragmatic referents). It also …

Educational Guidance And The Dangers Of Modern Communication Methods On High School Students, Sajjad Baqir Kazim

Uruk Journal of Human Sciences

The importance of researching the role of educational counseling in the educational institution and limiting the risks of modern means of communication to students and informing those in charge of the educational institution about the obstacles that educational counselors face during the performance of their work in order to identify them and find appropriate solutions to remove them and prevent their emergence, as well as give a picture to the scientific departments of the Department of Sociology and Service Social and Psychology and Counseling Department in preparing social workers, this research can benefit parents to know the real risks of …

Real Property, Real Problems: Expanding Alaska's Unfair Trade Practices And Consumer Protection Act, Michael E. Keramidas

Alaska Law Review

Alaska’s Unfair and Deceptive Acts and Practices (UDAP) statute was designed to provide broad, robust protections for everyday Alaskan consumers. Astonishingly, Alaska is one of only three states that does not protect Alaskans under its UDAP statute when they fall victim to fraudulent schemes involving real property. The Alaska Supreme Court has consistently upheld this interpretation of the UDAP statute by relying on precedent from over thirty years ago. At the same time, due to the COVID-19 pandemic, everyday Alaskans are more economically vulnerable than ever before, with the atmosphere being ripe for proliferation of fraudulent real property schemes. This …

Feeding Problems Of Preschool-Age Children With Autism Spectrum Disorder In Pathum Thani Province, Thailand, Issarapa Chunsuwan, Warapoj Ma-Eime, Tippawan Hansakunachai, Prapasri Kulalert, Tiraya Lerthattsilp

Asian Medical Journal and Alternative Medicine

Introduction: Feeding problems are commonly observed in children with autism spectrum disorder (ASD). Among feeding problems, food selectivity is the most common issue. Improper feeding behaviors could lead to health issues and difficulties in parenting. The objective of this research is to compare eating problems among preschool-age children with autism and children with typical development (TD).
Methods: This case-control study was conducted in 30 children with ASD and 30 age- and gendermatched children with TD. Parents of children from both groups answered demographic questionnaires, the Brief Autism Mealtime Behavior Inventory (BAMBI) and questionnaires about attitude and strategies toward their child’s …

The Effect Of Blended Learning Methods During The Covid 19 Pandemic On Students Ofthe Hospitalization Study Program, Wiyanti Wiyanti, Puput Dewi Anggraini

Journal of Indonesian Tourism and Policy Studies

The COVID-19 pandemic has impacted all sectors including the education sector, forcing the face-to-face learning process to switch to online learning. There are many obstacles when conducting online learning in vocational education, especially hospitality study programs, including during practical courses. In situations and conditions like this, the blended learning model is deemed appropriate and can be used as an alternative learning model that is able to combine online and face-to-face learning processes. This study intends to analyze the effect of the teaching and learning process through the blended learning model in increasing the learning independence of students in the hospitality …

Teaching Chinese Language Outside Of China: The Case Of Chinese Teachers In Thailand, Lim Chong Ewe, Feng Min

Asia-Pacific Social Science Review

To respond to the increasing demand for Chinese language teachers in Thailand, Hanban, a non-governmental, public organization affiliated with the Chinese Ministry of Education, has employed many Chinese teachers on a voluntary basis. Weighing on this matter, this study explored the perceptions of 13 Chinese language teachers of the difficulties and challenges of being Chinese teachers in Thailand. Online survey questionnaires and individual follow-up interviews were used to collect the data. Findings revealed that participants held a positive perception with regards to being Chinese language teachers in Thailand. Some reasons why they came to teach in Thailand included Thailand’s ancient …

Knowledge, Attitudes, And Practices Of Saudi Citizens On Covid-19 Pandemic: A Multi-Region Survey, Maha Sanat Alreshidi, Nojoud Abdullah Daaya Alreshidi, Ebaa Felemban, Ferdinand Gonzales

Makara Journal of Health Research

Background: Although policies and guidelines may not always be optimal in all settings, a tailor-fitted guideline is appropriate. This study aims to determine the differences in the knowledge, attitudes, and practices (KAP) of Saudi citizens toward Coronavirus Disease 2019 (COVID-19).

Methods: A quantitative-comparative-correlational approach was carried out from March 21 to May 22, 2020. Descriptive statistics, ANOVA, and t-test were used to determine the differences in knowledge and demographic characteristics. Linear regression was used to determine relationships among KAP.

Results: The participants’ knowledge yielded 82.83%, positive attitudes (M = 2.10; SD = 1.15) and good …

Trends And Determinants Of Family Planning Utilization Among Men In Indonesia, Haerawati Idris, Willyana Syafriyanti

Makara Journal of Health Research

Background: Population growth rate in the world is still increasing. To control population growth, governments issue family planning programs for married women and men. However, contraception use is still dominated by women. This study aims to analyze the trends and determinants of family planning utilization among men in Indonesia.

Methods: This study is quantitative in nature with a cross-sectional design, using secondary data from the Indonesian Health Demographic Survey (2007–2017). The sample comprised married men with a total of 27,859 respondents. For the final analysis, we conducted logistic regression statistical tests to determine family planning utilization among men. …

Evaluation Of Levofloxacin And Yahom-Navakot Remedy Extract Combination Therapy Against Antibiotic Resistant Bacteria In Vitro, Kitrawee Jiraratsatit, Sombat Muengtaweepongsa, Arunporn Itharat, Neal M. Davies

Asian Medical Journal and Alternative Medicine

Introduction: Antibiotic resistant bacteria are being considered a serious public health challenge. Levofloxacin is a broad-spectrum antibiotic, developed to replace previously resistant antimicrobials. The use of natural products as an antimicrobial drug is an alternative way to reduce bacterial resistance by synthesized drugs and enhance their efficacy. Yahom-Navakot (YN) is a Thai remedy in the Thai essential drug list. The indications for YN treatment are to relieve fatigue, dizziness, malaise, and vomiting after alleviation of fever. Previous studies have reported antibiotic enhancing effects of YN. This study was aimed to evaluate the antibacterial activities of levofloxacin and Yahom-Navakot Remedy Extract. …

Impact Of Motile Ciliopathies On Human Development And Clinical Consequences In The Newborn, Rachael Hyland, Steven L. Brody

Open Access Publications

No abstract provided.

Empowering Nurses To Go The Extra Mile Through Ethical Leadership: A Covid-19 Context, Kaleem Ullah Irfan, Talat Islam

Asia-Pacific Social Science Review

This study attempts to investigate how ethical leadership enhances nurses’ in-role and extra-role performances with the mediation of psychological empowerment. We used a cross-sectional time-lag design and collected data from 371 nurses and their immediate supervisors through a questionnaire-based survey. The data on ethical leadership and psychological empowerment were collected from nurses at T1, whereas data on in-role and extra-role performance were collected from their immediate supervisors at T2. The results revealed positive associations of ethical leadership with psychological empowerment, in-role, and extra-role performance. Further, hierarchical regression confirms the mediating role of psychological empowerment between the associations of ethical leadership …

العدالة التنظيمية والصمت التنظيمي/ العلاقة والأثر: دراسة لعينة من الافراد العاملين في مديرية تربية محافظة نينوى, سجى نذير حميد الصراف

Muthanna Journal of Administrative and Economics Sciences

قرار العاملين في حجبهم للمعلومات و الافكار والآراء مسألة في غاية الاهمية لما لها آثار سلبية على اداء العاملين والمنظمة معا” وبدورها تؤدي الى احداث ظاهرة غير مرغوب بها داخل المنظمة تسمى الصمت التنظيمي, وأسباب تلك الظاهرة عديدة ومتنوعة وقد تكون العدالة التنظيمية واحدة من تلك الاسباب , ومن هذا المنطلق سيتم توضيح علاقة العدالة التنظيمية بحدوث ظاهرة الصمت التنظيمي وما تاثير العدالة التنظيمية في الصمت التنظيمي, و في ضوء ذلك تم طرح التساؤلات الاتية :- هل يرتبط بتحقيق العدالة التنظيمية في المنظمة المبحوثة بظاهرة الصمت التنظيمي؟ هل هناك تأثير للعدالة التنظيمية على حدوث الصمت التنظيمي لدى العينة المبحوثة ؟ …

Effect Of Dry Oxidation And Thermal Annealing On Aln/Gan/Aln/Si (111) And Evaluation Of Its Electrical Characteristics, Mohd Zaki Mohd Yusoff, Azzafeerah Mahyuddin, Zainuriah Hasssan, ‪Muhammad Syarifuddin Yahya

Makara Journal of Science

We proposed a technique for improving the platinum (Pt) Schottky contact dark current of the AlN/GaN/AlN/Si(111) substrate. The AlN/GaN/AlN/ heterostructure sample was successfully grown on a silicon substrate by radio frequency molecular beam epitaxy. The high quality of the interlayer heterostructure sample was verified by transmission electron microscopy (TEM). From the TEM image, a good quality single interface layer with spacing less than 1 nm was detected. The strong significant peaks obtained by X-ray diffraction measurement indicated that the sample has a high structural quality for each grown layer. Dry oxidation and thermal annealing were used in conjunction to effectively …

Silver Bow Creek/Butte Area Npl Site, Trec Inc., A Woodard And Curran Company

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Keberlakuan Klausula Security Exceptions Dalam Perjanjian Trade-Related Aspects Of Intellectual Property Rights (Trips) Di Masa Pandemi Covid-19, Daniel Nicholas Putra, Yetty Komalasari Dewi Ykd

Jurnal Hukum & Pembangunan

WTO commitments, particularly related to intellectual property rights in the TRIPS Agreement, could potentially hinder efforts to increase access to medicines and vaccines during the Covid-19 pandemic. In time of emergency, these commitments can be overridden using the WTO security exceptions clause. This article compares the WTO security exceptions to general exceptions in Article XX of the GATT 1994 and non-precluded measures in the Argentina-US BIT, India-Germany BIT, and India-Mauritius BIT, and analyses how the Covid-19 pandemic can be a valid reason to waive the obligations under the TRIPS Agreement using the security exceptions clause. In particular, this article discusses …

Cyberbullying Victimization As A Predictor Of Depressive Symptoms Among Selected Adolescents Amidst The Covid-19 Pandemic, Jeyaseelan Maria Michael, Marc Eric Reyes

Makara Human Behavior Studies in Asia

Cyberbullying victimization has become a significant mental health concern, particularly among adolescents at risk of experiencing negative consequences like depression. As the outbreak of the Covid-19 pandemic forced everyone to stay at home and participate in all their educational, recreational, and entertainment activities online, this study investigated the relationship between cyberbullying victimization (CV) and depressive symptoms among 612 college students in Tamilnadu, India. We hypothesized that experiences of cyberbullying victimization would predict depressive symptoms among the participants. Adolescent participants aged 18 to 19 years old from colleges in Tamilnadu completed an online survey composed of the Cybervictimization questionnaire for adolescents …

Parental Decisions On Sharing Their Children's Private Information On Social Media Among Families In Jakarta Area, Putri Wardhani, Laras Sekarasih

Makara Human Behavior Studies in Asia

The practice of publishing photos and videos containing children’s private information on social media—also known assharenting—is popular among parents in Jakarta. Embarking from the debate about privacy paradox in which it is believed that privacy concern does not predict someone’s behaviors in managing his/her private information online, this research tries to reveal the considerations underlying parental decisions when sharing their children’s private information through social media and their perceived risk toward their children’s online safety. Using qualitative approach, the researcher conducted interviews with 20 parents in Jakarta with at least one child younger 13 year old. The result suggests that …

Family Resilience Model: The Influence Of Cultural Identity, Coping, Family Strain, Socioeconomic Status, And Community Support To The Formation Of Family Resilience Among Batak Toba Ethnic Group, Sri Redatin Retno Pudjiati, Sri Hartati Dewi Reksodiputro, R. Urip Purwono

Makara Human Behavior Studies in Asia

A resilient family is a family that is capable of survival, overcoming difficult challenges, and then grow stronger (Walsh, 2006). Cultural identity is one of the factors that play a role in forming family resilience, because in order to build the understanding and values of family resilience one needs to build it in accordance to local culture. The purpose of this study is to analyze the factors that build family resilience in Indonesian families, especially Batak Toba families. The measurement tool used in this study is Walsh Family Resilience Questionnaire (WFRQ) to measure family resilience (α = .879), The Responses …

Visioning Science, Governance, Whole-Of-Government Strategy, Romeo B. Lee

Asia-Pacific Social Science Review

No abstract provided.

Empowering Nurses To Go The Extra Mile Through Ethical Leadership: A Covid-19 Context, Kaleem Ullah Irfan, Talat Islam

Asia-Pacific Social Science Review

This study attempts to investigate how ethical leadership enhances nurses’ in-role and extra-role performances with the mediation of psychological empowerment. We used a cross-sectional time-lag design and collected data from 371 nurses and their immediate supervisors through a questionnaire-based survey. The data on ethical leadership and psychological empowerment were collected from nurses at T1, whereas data on in-role and extra-role performance were collected from their immediate supervisors at T2. The results revealed positive associations of ethical leadership with psychological empowerment, in-role, and extra-role performance. Further, hierarchical regression confirms the mediating role of psychological empowerment between the associations of ethical leadership …

Communicative Action In Covid-19 Prevention: Does Religiosity Play A Role?, Ying Shin Chin

Asia-Pacific Social Science Review

Coronavirus disease (COVID-19) has presented the world with a major challenge in curbing infection. Information is important for public awareness of the pandemic and its prevention as part of the problem-solving efforts. Grounded on the situational theory of problem solving (STOPS), this study extends the theory by adding religiosity, an important factor that affects health-related behaviors, to examine its role as an antecedent to the situational perceptions that motivate people to take communicative action in preventing COVID-19, and to investigate the factors that lead to precautionary behavior in response to the pandemic. Based on the online survey responses from 371 …

A Review Of Rice Tariffication In The Time Of Covid-19: Rationale And Road To Rice Self-Sufficiency In The Philippines, David Michael M. San Juan

Asia-Pacific Social Science Review

The Philippine government passed the Rice Tariffication Law (RTL) in 2019, despite a strong and united peasant opposition to rice industry liberalization, which the RTL facilitates and further accelerates. Amid falling Filipino farmers’ incomes due to the deluge of imported rice, negligible milled rice price decreases for consumers, rising rice prices globally, and in the context of the COVID-19 pandemic that has already disrupted food supplies and is poised to cause continuing instability in the price of imports, this paper is aimed at reviewing recent rice tariffication policy literature. Such review will be a springboard in making a case in …