Digital Commons Network^™

Systemic Sclerosis Associated Interstitial Lung Disease: A Conceptual Framework For Subclinical, Clinical And Progressive Disease, David Roofeh, Kevin K Brown, Ella A Kazerooni, Donald Tashkin, Shervin Assassi, Fernando Martinez, Athol U Wells, Ganesh Raghu, Christopher P Denton, Lorinda Chung, Anna-Maria Hoffmann-Vold, Oliver Distler, Kerri A Johannson, Yannick Allanore, Eric L Matteson, Leticia Kawano-Dourado, John D Pauling, James R Seibold, Elizabeth R Volkmann, Simon L F Walsh, Chester V Oddis, Eric S White, Shaney L Barratt, Elana J Bernstein, Robyn T Domsic, Paul F Dellaripa, Richard Conway, Ivan Rosas, Nitin Bhatt, Vivien Hsu, Francesca Ingegnoli, Bashar Kahaleh, Puneet Garcha, Nishant Gupta, Surabhi Khanna, Peter Korsten, Celia Lin, Stephen C Mathai, Vibeke Strand, Tracy J Doyle, Virginia Steen, Donald F Zoz, Juan Ovalles-Bonilla, Ignasi Rodriguez-Pinto, Padmanabha D Shenoy, Andrew Lewandoski, Elizabeth Belloli, Alain Lescoat, Vivek Nagaraja, Wen Ye, Suiyuan Huang, Toby Maher, Dinesh Khanna

Faculty, Staff and Students Publications

OBJECTIVES: To establish a framework by which experts define disease subsets in systemic sclerosis associated interstitial lung disease (SSc-ILD).

METHODS: A conceptual framework for subclinical, clinical and progressive ILD was provided to 83 experts, asking them to use the framework and classify actual SSc-ILD patients. Each patient profile was designed to be classified by at least four experts in terms of severity and risk of progression at baseline; progression was based on 1-year follow-up data. A consensus was reached if ≥75% of experts agreed. Experts provided information on which items were important in determining classification.

RESULTS: Forty-four experts (53%) completed …

Perceptions Of Nursing Staff On Restraint Alternatives, Adelia S. Perea

Doctor of Nursing Practice Scholarly Projects

Physical restraint is often used as a nursing intervention for patients with behavioral issues despite current evidence that indicates their use is actually more harmful than helpful. Nursing staff at UNMH are required by policy to use other methods such as restraint alternatives before placing patients in restraint. However, they do not have the necessary resources or tools to comply with the policy. The NPCU conducted a quality improvement project that introduced 5 restraint alternatives followed by a survey focused on nursing perceptions. The results revealed 2 alternatives (Gamewright GoPOP sensory toy & Playtivity sensory disc) were perceived by nursing …

The Prospector, May 2, 2023, Utep Student Publications

The Prospector

Headline: Parting Words from the President

Effect Of Motivational Music On Peak Knee Torque, Perceived Exertion, And Enjoyment In College-Aged Individuals, Arianna Cole

Undergraduate Honors Theses

There is a general consensus in previous and current literature that the incorporation of music in exercise has the potential to benefit performance (Karageorghis 2020; Terry et al. 2019). Research on the potential benefits of music in rehabilitative exercise has become more prevalent but has mainly focused on music and the rehabilitation of neurological conditions such as Parkinson's disease or stroke (Craig et al. 2015; De Bartolo et al. 2020; Grau-Sánchez et al. 2022; Katlen da Silva et al. 2021; Särkämö 2018). Research in a more general rehabilitative setting has not been explored as widely and this is the aim …

Race In The Relationship Quality Of Sexual Minority People Of Color: A Meta-Analytic Review, Olivia M. Lawrence

Undergraduate Honors Theses

No abstract provided.

Improving Access To General Education Via Co-Teaching In Secondary Mathematics Classrooms: An Evaluation Of Utah's Professional Development Initiative, Kaitlin Bundock, Kristen Rolf, Anna Hornberger, Chamy Halliday

Special Education and Rehabilitation Counseling Faculty Publications

Co-teaching may be a promising strategy to improve inclusive secondary mathematics education in rural schools. Professional development (PD) aids in special and general education teachers' co-teaching implementation, yet little empirical research examines how to effectively train and support co-teachers. In this study we describe one U.S. state's PD model for secondary mathematics co-teaching, evaluate outcomes of the PD on co-teachers' behaviors and beliefs, and examine the impact of co-teaching on students' mathematics achievement. We examined data from observations, surveys, and students' pre/post assessments across nine classes within seven U.S. school districts, including three rural school districts, over 3 years. We …

Spartan Daily, May 2, 2023, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2023

Volume 160, Issue 38

Effect Of High Fat Vs High Sugar Diet On Mtor Signaling Pathway In Skeletal Muscle Of Male And Female Mice, Zereque Powell

Electronic Theses and Dissertations Archive

Background: Obesity and MetS has been shown to negatively impact protein synthesis rates. Objective: Determine the effects of sex and high fat/high sugar diets on mTOR signaling pathways. Methods: 15 male and 15 female wild type C57BL/6 mice were randomized into 3 groups: High Fat (45% fat), High Sugar (60% carb) and Control. While continuing diets, body weight and body composition were monitored. Following sacrifice, muscles were examined for changes in the mTOR signaling pathway. Results: Mice consuming the HF diet had the highest levels of weight gain. Females expressed higher levels of expression of P-AMPK. Levels of REDD1 were …

Self-Compassion And Psychological Flexibility: A Meta-Analysis Of Relations, Jordan Moreno

Electronic Theses and Dissertations Archive

Abstract This meta-analysis sought to examine the relation between self-compassion and psychological flexibility as well as to add to the literature pertaining to potential moderators of this relation. The study extracted 104 unique effect sizes (Pearson’s r) from 44 samples, with data from 11,660 participants. Consistent with prior research, results indicated a moderate positive relation (.62) between self-compassion and psychological flexibility. However, the study did not find any significant moderation effects for age or gender. All studies used a variation of the Self-Compassion Scale (SCS) including the Self-Compassion Scale – Short Form and the Self-Compassion Scale – Positive Factors. The …

Diplomacy In 280 Characters: An In-Depth Content And Comparative Analysis Of Official State Twitter Accounts, Audrey Firrone

Electronic Theses and Dissertations Archive

This study conducted a content and comparative analysis of 17 states’ official Twitter accounts to analyze textual and visual content posted. The types of content, communication models, and visuals were analyzed to determine how states use Twitter as a form of digital diplomacy. A sample of 730 tweets (n = 374, n = 356) was taken from official state accounts. The present study found that the type of content posted varied by freedom level, with international issues and interstate cooperation themes being the most common among states. Additionally, the method of communication varied based on freedom level, with more free …

Does Vocalization Increase The Positive Valence Of Emotion?, Joshua Hyde

Electronic Theses and Dissertations Archive

This study aims to determine if the act of voicing can have an effect on mood in a within-participant reversal paradigm, where each participant served as their own control. Following a baseline condition, participants underwent three experimental conditions: breathing, articulating, and voicing. Following baseline and experimental conditions, participants underwent an emotion-induction paradigm by looking at pictures. They rated their current mood and arousal levels following each picture. Additionally, psychophysiological measures of facial electromyography, electrocardiography, and electrodermal responses were gathered throughout the experiment. Results were mixed, revealing that there was a mood change during aversive picture viewing toward positive moods in …

Evaluating Item Bias And Equitability Of The Pediatric Quality Of Life Inventory- Diabetes Module 5 Item Version Amongst Income And Racially Diverse Youth Living With Type 1 Diabetes, Kasey Harry

Electronic Theses and Dissertations Archive

Type 1 Diabetes (T1D) is one of the most common chronic diseases among children in the United States, affecting around 244,000 children and adolescents. In 2014–2015 around 18,200 youth were diagnosed with T1D. T1D requires youth to participate in complex and burdensome health behaviors that can affect health-related quality of life (HRQoL). Measures such as the Pediatric Quality of Life Inventory- Diabetes Module Version 3.2 (PedsQL-DM) are used to determine how T1D has influenced youth and caregivers’ daily lives. Recently, a 5-item version of the Pediatric Quality of Life Inventory- Diabetes Module (PedsQL-DMSF5) was developed; however, it is presently unclear …

Evaluating The Impact Of The Shelby Farms Greenline As An Equitable Transportation Source Through The Use Of Streetlight Data Analytics, Logan Nelson Sirbaugh

Electronic Theses and Dissertations Archive

This study employs the use of StreetLight Data analytics to evaluate the Shelby Farms Greenline in Memphis, TN as an equitable pedestrian transportation source. A comprehensive literature review was conducted to identify current practices in equitable pedestrian infrastructure design and pedestrian data collection methods. Using American Community Survey data (annual household income and race/ethnicity), four access points were identified along the Greenline based on demographic and geographic representation. Each location was analyzed using traveler and trip attributes provided by StreetLight data to evaluate pedestrian use of the Greenline. The results of StreetLight Data were validated using two permanent pedestrian counters …

Relative Discretionary Expenditures On Alcohol As An Indicator Of Alcohol Use Severity In A Diverse Emerging Adult Sample, Jackie Austin Varner

Electronic Theses and Dissertations Archive

Relative discretionary expenditures towards alcohol (RDEA) is a behavioral economic measure that uses patterns of resource allocation (money) to alcohol versus other activities as an index of the relative reinforcing efficacy of alcohol. RDEA can be predictive of treatment response and is positively associated with alcohol use and consequences, but has not been validated in a diverse sample of emerging adults. This study hypothesized that RDEA would be an indicator of alcohol use severity and investigated associations among RDEA, alcohol use, and alcohol problems, as well as relationships among two measures of relative reinforcing efficacy (RRE) to establish construct validity …

Engaging The Vulnerable: Health Literacy For Children Combating Non Communicable Diseases In Sub Saharan Africa, A Review, Madireng Monyela

Library Philosophy and Practice (e-journal)

Background: Instilling health literacy in children could reduce the chances of poor health behaviours and non-communicable diseases (NCDs). Good childhood health literacy has been associated with routinely having a healthier diet, as well as a better understanding and use of nutritional information on foods and drinks. Building resilience in childhood through health literacy programmes can also have a positive impact on psychological health and well-being across the life course, and reducing the severity of depression experienced in adulthood among other diseases.

Objectives: The objectives of the study were to find out how health literacy is offered to children in sub-Saharan …

Shiftable Load Forecasting And User-Centric Demand-Side Optimization For Nanogrid, Akash Kumar

Theses

Increased focus on sustainability and energy decentralization has positively impacted the adoption of nanogrid (NG). Despite its perceived advantages, NG’s high load volatility poses risk not only to its stability but also to the associated network. This is further exacerbated by the user’s transient moods and the probabilistic nature of metrological events. Moreover, unoptimized operation of electrical appliances in a NG, especially in peak hours, raises the energy cost substantially. Thus, for risk aversion and cost savings, day-ahead demand-side optimization is highly required, especially for shiftable loads. Moreover, most load centers, aspiring to be NGs, have either limited or no …

Parkin Ubiquitination Of Kindlin-2 Enables Mitochondria-Associated Metastasis Suppression, Minjeong Yeon, Irene Bertolini, Ekta Agarwal, Jagadish C Ghosh, Hsin-Yao Tang, David W. Speicher, Frederick Keeney, Khalid Sossey-Alaoui, Elzbieta Pluskota, Katarzyna Bialkowska, Edward F. Plow, Lucia R. Languino, Emmanuel Skordalakes, M Cecilia Caino, Dario C. Altieri

Department of Pharmacology, Physiology, and Cancer Biology Faculty Papers

Mitochondria are signaling organelles implicated in cancer, but the mechanisms are elusive. Here, we show that Parkin, an E3 ubiquitination (Ub) ligase altered in Parkinson's disease, forms a complex with the regulator of cell motility, Kindlin-2 (K2), at mitochondria of tumor cells. In turn, Parkin ubiquitinates Lys581 and Lys582 using Lys48 linkages, resulting in proteasomal degradation of K2 and shortened half-life from ∼5 h to ∼1.5 h. Loss of K2 inhibits focal adhesion turnover and β1 integrin activation, impairs membrane lamellipodia size and frequency, and inhibits mitochondrial dynamics, altogether suppressing tumor cell-extracellular matrix interactions, migration, and invasion. Conversely, Parkin does …

Challenges Of Cataloguing Library Resources In The Evolving Digital Environment: The African Cataloguer’S Experience, Madireng Monyela

Library Philosophy and Practice (e-journal)

The paper examines the challenges of cataloguing library resources, in the City of Cape Town Metropolitan Public Libraries (CCTML), South Africa. The paper was necessitated by the postulation that, the extent of access and the use of library resources depends greatly upon the quality of the library catalogue. The following research questions were formulated: what cataloguing knowledge do cataloguers of CCTML have? How is cataloguing carried out in CCTML? What challenges do cataloguers of CCTML experience in cataloguing library resources? Qualitative approach and case study design were employed. The population of the study was made of 6 cataloguers. Data was …

Awareness, Perceptions And Reactions On The Science Hub (Sci-Hub) Website Use Among Postgraduate Students Of Usmanu Danfodiyo University, Sokoto, Mohammed Kpakiko, Aina Adebowale Japhet, Muhammad Zannah-Bukar Badia

Library Philosophy and Practice (e-journal)

The study investigated the awareness, perceptions and reactions on the Science Hub (Sci-Hub) website use among the postgraduate students of Usmanu Danfodiyo University, Sokoto. The objectives of the study were to find out the postgraduate students’ level of awareness, perceptions and contributions of Science Hub website use for research and to ascertain their reactions and extent of satisfaction with it. The study adopted the survey research design. The population for the study comprised of postgraduate students of the university. Four faculties namely: Science, Health, Veterinary and Agriculture were purposively selected for the study. This is due to the fact that …

Adiposity-Associated Atrial Fibrillation: Molecular Determinants, Mechanisms, And Clinical Significance, Monika Gawałko, Arnela Saljic, Na Li, Issam Abu-Taha, Thomas Jespersen, Dominik Linz, Stanley Nattel, Jordi Heijman, Anke Fender, Dobromir Dobrev

Faculty, Staff and Students Publications

Obesity is an important contributing factor to the pathophysiology of atrial fibrillation (AF) and its complications by causing systemic changes, such as altered haemodynamic, increased sympathetic tone, and low-grade chronic inflammatory state. In addition, adipose tissue is a metabolically active organ that comprises various types of fat deposits with discrete composition and localization that show distinct functions. Fatty tissue differentially affects the evolution of AF, with highly secretory active visceral fat surrounding the heart generally having a more potent influence than the rather inert subcutaneous fat. A variety of proinflammatory, profibrotic, and vasoconstrictive mediators are secreted by adipose tissue, particularly …

Enhancing The Battleverse: The People’S Liberation Army’S Digital Twin Strategy, Joshua Baughman

Military Cyber Affairs

No abstract provided.

What Senior U.S. Leaders Say We Should Know About Cyber, Dr. Joseph H. Schafer

Military Cyber Affairs

On April 6, 2023, the Atlantic Council’s Cyber Statecraft Initiative hosted a panel discussion on the new National Cybersecurity Strategy. The panel featured four senior officials from the Office of the National Cyber Director (ONCD), the Department of State (DoS), the Department of Justice (DoJ), and the Department of Homeland Security (DHS). The author attended and asked each official to identify the most important elements that policymakers and strategists must understand about cyber. This article highlights historical and recent struggles to express cyber policy, the responses from these officials, and the author’s ongoing research to improve national security cyber policy.

Operationalizing Deterrence By Denial In The Cyber Domain, Gentry Lane

Military Cyber Affairs

No abstract provided.

State-Level Macro-Economic Factors Moderate The Association Of Low Income With Brain Structure And Mental Health In U.S. Children, David G Weissman, Mark L Hatzenbuehler, Mina Cikara, Deanna M Barch, Katie A Mclaughlin

2020-Current year OA Pubs

Macrostructural characteristics, such as cost of living and state-level anti-poverty programs relate to the magnitude of socioeconomic disparities in brain development and mental health. In this study we leveraged data from the Adolescent Brain and Cognitive Development (ABCD) study from 10,633 9-11 year old youth (5115 female) across 17 states. Lower income was associated with smaller hippocampal volume and higher internalizing psychopathology. These associations were stronger in states with higher cost of living. However, in high cost of living states that provide more generous cash benefits for low-income families, socioeconomic disparities in hippocampal volume were reduced by 34%, such that …

Covid-19, Pemenjaraan Berlebihan, Dan Potensi Katastrofe Kemanusiaan, Iqrak Sulhin

Jurnal Hukum & Pembangunan

On March 2, 2020 Indonesia recorded the Covid-19 case for the first time. Since then the trend in the number of infections has continued to increase. Likewise, the number of deaths. To anticipate the spread within the Penitentiary (Lapas), the Ministry of Law and Human Rights is releasing prisoners, through accelerating assimilation and parole. Similar policies have also been carried out by other countries in the world and are recommended by international institutions, such as the World Health Organization and the United Nations Office on Drugs and Crimes. However, the main problem behind this policy is the overcrowding condition in …

Innocent Until Presented, Aristo Pangaribuan

Jurnal Hukum & Pembangunan

This paper analyzes a practice of presenting suspects, which is a ritual that displays a suspect before the media. Until now, although it is frequently used by the police, there has been no attempt to examine such practices in Indonesia. In the criminal procedure scholarship, there is no standard term to describe it. This article will refer to such ritual as a presentation of suspects. This ritual has also been practiced around the world with different methods and has a long history, especially in the United States. This article discusses the presentation of suspects and question whether such a ritual …

Rgensi Meratifikasi Framework Convention On Tobacco Control (Fctc) Dalam Upaya Pengendalian Konsumsi Tembakau Di Indonesia, Fajar Kurniawan

Jurnal Hukum & Pembangunan

The current problem of tobacco consumption has become a global issue that covers almost all aspect of life, both economic, social and community welfare aspects, especially for the health aspects because of the impact of the healt losses they cause. Cigarette consumption in Indonesia continues to experience a significant increase. Indonesia is the thrid country with the highest number of smokers in the world. Global tobacco consumption control has been stated in Framework Convention on Tobacco Control (FCTC) since 2003, but until now Indonesia has not ratified that FCTC. As part of the civilization of the international community, it is …

Review Of Lewis & Tolkien—Of Wardrobes And Rings (Play), James P. Helfers

Sehnsucht: The C. S. Lewis Journal

Review of Lewis & Tolkien—of Wardrobes and Rings, by David Payne, starring David Payne and Gordon Tett. Tempe, Arizona: Sun Valley Community Church, 8 March 2019.

Review Of The Celian Moment And Other Essays, Sørina Higgins

Sehnsucht: The C. S. Lewis Journal

Review of Charles Williams, The Celian Moment and Other Essays, ed. by Stephen Barber (Carterton, West Oxfordshire: The Greystones Press, 2017). xxvii + 127 pages. $17.43. ISBN 9781911122111.

Review Of Inklings Of Truth: Essays To Mark The Anniversaries Of C. S. Lewis And J. R. R. Tolkien, Bruce R. Johnson

Sehnsucht: The C. S. Lewis Journal

Review of Paul Shimpton, ed., Inklings of Truth: Essays to Mark the Anniversaries of C. S. Lewis and J. R. R. Tolkien, Grandpont Papers 3 (Oxford: Grandpont House, 2018). 102 pages. $10.09. ISBN 9780952216728.