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Predictive Modeling Using Clinical Data And Compositional Microbiome Data, Li Zhang Jan 2024

Predictive Modeling Using Clinical Data And Compositional Microbiome Data, Li Zhang

All ETDs from UAB

This dissertation focuses on developing predictive modeling using data from two areas: clinical data and microbiome data. Compositional data in real life are mainly represented by relative proportions. With the advancement of next-generation sequencing (NGS) technology, researchers can now collect a large volume of metagenomic sequencing data, which is valuable for investigating associations between the microbiome and host diseases. Current methods for dealing with such data are either constrained by generalization or limited by application. In the first part, to address this, we propose Bayesian compositional generalized linear models for analyzing microbiome data (BCGLM). This model incorporates a structured regularized …

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"Stitched By An Indifferent Hand: Recognizing The Marginal In Cormac Mccarthy's 'Suttree'", Michael Wayne Boody Jan 2024

"Stitched By An Indifferent Hand: Recognizing The Marginal In Cormac Mccarthy's 'Suttree'", Michael Wayne Boody

All ETDs from UAB

For centuries, philosophers have been kept busy by the question of what it means to be recognized. In the early 1990’s the Critical theorist Axel Honneth synthesized ideas put forth by Hegal and George Herbert Mead to propose his theory of Recognition, which suggests that society advances forward when humans exercise moral recognition of each others’ positive attributes; only then can people within society achieve a positive-relation-to-self. While Recognition is not greatly applied to literary theory, I believe that we can use it to explain the main character’s interactions with the people in his community in Cormac McCarthy’s Suttree (1979). …

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Exploring The Associations Between Cognitive Training, Social Determinants Of Health, And Driving Behaviors: A Longitudinal Analysis Of The Active Study, Katie Wheeler Jan 2024

Exploring The Associations Between Cognitive Training, Social Determinants Of Health, And Driving Behaviors: A Longitudinal Analysis Of The Active Study, Katie Wheeler

All ETDs from UAB

As the average lifespan increases, older adults are remaining independent into older ages than before. The ability to drive a vehicle is an essential part of daily living that helps older adults maintain independence. Cognitive training, specifically speed of processing training (SOPT), is an intervention that has consistently shown to benefit older adult’s driving abilities and driving behaviors. This dissertation examined the longitudinal association between cognitive training and primary driving location on crash risk across 20 years (Paper 1), investigated the effects of cognitive training and dosage on driving mobility across 10 years (Paper 2), and explored social determinants of …

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The Prescription Drug Monitoring Program And Its Effect On Drug Overdose Mortalities, Charles Lee Jan 2024

The Prescription Drug Monitoring Program And Its Effect On Drug Overdose Mortalities, Charles Lee

All ETDs from UAB

The opioid epidemic is a growing concern, and the health and economic impacts on rural and urban counties are increasing. Between 1999 and 2019, approximately 841,000 people died from drug overdoses involving heroin, synthetic opioids, and prescribed opioids with 71,000 dying in 2019. This study examined the relationship between drug overdose mortalities and three independent variables, (a) Medicaid expansion, (b) Years PDMP active, and (c) Academic detailing engagement. Results of this study will contribute to the literature by determining if the Medicaid expansion, years prescription drug monitoring programs active, and academic detailing engagement decrease drug overdose mortalities. This study includes …

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Fundamentals Of Vehicle Modeling For Mobility And Maneuver, Jordan Whitson Jan 2024

Fundamentals Of Vehicle Modeling For Mobility And Maneuver, Jordan Whitson

All ETDs from UAB

The direction of research for off-road ground vehicles is an ever-growing interdisciplinary field. The strategies and modeling methods range from simple terramechanics mathematical models to complex terramechanics that involve the use of high-performance computing (HPC) systems with varying vehicle metric and performance analysis and information extraction. Current advanced methods based on terrain properties and dynamic models utilize conventional performance metrics that have been supported through decades of research. As automated driving systems (ADS) and unmanned ground vehicles (UGVs) research and development progress, more complexities are unraveled and present the need for novel directions of research. Whereas on-road vehicles have the …

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Using The Social Ecological Model To Assess The Correlates Of Unprotected Sex Among African American Emerging Adults, Shirlacia S. Gray Jan 2024

Using The Social Ecological Model To Assess The Correlates Of Unprotected Sex Among African American Emerging Adults, Shirlacia S. Gray

All ETDs from UAB

USING THE SOCIAL ECOLOGICAL MODEL TO ASSESS THE CORRELATES OF UNPROTECTED SEX AMONG AFRICAN AMERICAN EMERGING ADULTS SHIRLACIA S. GRAY DEVELOPMENTAL PSYCHOLOGY ABSTRACT Background: The Centers for Disease Control and Prevention (CDC) reported that HIV diagnoses for Black/African American men and women are 8x and 15x higher than white individuals, respectively. While the social determinants of health largely influence HIV transmission rates, reducing risky behaviors can lower the risk for HIV. This current study used the Social Ecological Model to investigate correlates of unprotected sex. Methods: Participants were recruited through respondent-driven sampling. Participant's demographics (age, gender, years of education, financial …

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The Impact Of O-Glcnac Signaling On Dna Hydroxymethylation In Temporal Lobe Epilepsy, Rudhab Bahabry Jan 2024

The Impact Of O-Glcnac Signaling On Dna Hydroxymethylation In Temporal Lobe Epilepsy, Rudhab Bahabry

All ETDs from UAB

Temporal Lobe Epilepsy (TLE) is the most prevalent form of focal epilepsy and the most treatment-resistant type. This condition is characterized by recurrent, unprovoked seizures typically originating in the hippocampus. Epigenetic modifications such as DNAme changes have been implicated in brain functions such as synaptic plasticity, learning and, memory, and cognition. The oxidation of DNA 5-methylcytosine (5-mC) and its oxidized form, 5-hydroxymethylcytosine (5-hmC) catalyzed by Ten-Eleven Translocation (TET) family of dioxygenases and linked to epilepsy's hyperexcitable state. Post‐translational modifications (PTMs) of proteins, such as O-GlcNAcylation, facilitate cells' immediate responses to intracellular or extracellular environmental stimuli by modifying the functions of …

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3d Microtissue Model Of The Aged Ovarian Tumor Microenvironment, Peyton Clark Jan 2024

3d Microtissue Model Of The Aged Ovarian Tumor Microenvironment, Peyton Clark

All ETDs from UAB

Ovarian cancer is the 5th leading cause of cancer deaths for women, primarily due to treatment resistant and/or recurrent disease. Most cases of ovarian cancer are not diagnosed until distant metastases have formed, which drastically reduces overall survival. The median age at diagnosis is 63 and most cases occur in patients who are peri- and post-menopausal. There is a critical gap between the clinical presentation of ovarian cancer and the preclinical models used to study the disease. Most preclinical in vivo investigations use mice who are between 6 and 12 weeks old, which corresponds to roughly a 20-year-old human. Therefore, …

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Multi-Enclave Blockchain Architecture Integrating Useful Work For Member Selection In Committee-Based Consensus, Shawn C. Adams Jan 2024

Multi-Enclave Blockchain Architecture Integrating Useful Work For Member Selection In Committee-Based Consensus, Shawn C. Adams

All ETDs from UAB

Blockchains offer an alternative approach to centralized systems for data and record storage by using independently operated nodes in a distributed and decentralized network. Within a blockchain network, each node maintains an identical version of all data, without being directly controlled or managed by any centralized entity. Nodes maintain the synchronization of data through the network's consensus mechanism, a protocol built into the nodes to determine which node is given the right to append data to the network. Once chosen, the data added by the node is propagated to other nodes which update their local records to maintain synchronization. Common …

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Early Childhood Educators’ Perceptions, Attitudes, And Beliefs On Use Of The Modern Classrooms Project: A Case Study, Christina Arriagada Jan 2024

Early Childhood Educators’ Perceptions, Attitudes, And Beliefs On Use Of The Modern Classrooms Project: A Case Study, Christina Arriagada

All ETDs from UAB

The purpose of this qualitative study was to explore how early childhood educators perceive the use of Modern Classrooms Project (MCP) in their classrooms. MCP is an instructional model that promotes blended, self-paced, and mastery-based learning with ties to constructivist teaching ideals. Data were collected using a teacher interview, observations, and the review of teacher resources such as lesson plans and student learning paths. Previous research found MCP was effective at the secondary level. Findings of this study showed that early childhood educators found MCP to be an effective instructional model to use in their classrooms. I identified three themes: …

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Filing The Serial Numbers Off: The Role Of The Author In Fanfiction Published As Original Fiction, Lauren Mcinnis Jan 2024

Filing The Serial Numbers Off: The Role Of The Author In Fanfiction Published As Original Fiction, Lauren Mcinnis

All ETDs from UAB

With the increase of authors altering and publishing fanfiction as original works of fiction, the practices and attitudes of fan communities cross over into the realm of traditional fiction. Throughout its history, fandom is a community built on the shared love of a piece of media or celebrity. The importance of community appears in fanfiction through Author’s Notes and comments sections; both of which traditionally published novels generally lack. When authors choose to make the transition to traditional publication which provides legitimacy that fanfiction lacks, they must remove most of their own identity and the fan-community that they originally relied …

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Comparative Enzymatic Analysis Of Different Isoforms Of Group A Streptococcal Bacteriophage H4489a Hyaluronidase, Urvi Prakash Rawal Jan 2024

Comparative Enzymatic Analysis Of Different Isoforms Of Group A Streptococcal Bacteriophage H4489a Hyaluronidase, Urvi Prakash Rawal

All ETDs from UAB

The Hyaluronate Lyase derived from Group A streptococcal bacteriophage H4489A gene (HylP) is known for cleaving the glycosidic bonds of high molecular weight hyaluronic acid (HMWHA), a substance often overexpressed in certain types of cancer cells. This enzymatic action produces HA oligosaccharides. Previous research, conducted by our team, has demonstrated that these oligosaccharides play a significant role in reducing the invasion, migration, and proliferation of breast cancer cells. This effect occurs through the disruption of Erk1/2 activation and RhoA expression. This bacteriophage hyaluronate lyase (HylP), a 40kDa protein, possesses a unique collagen-like sequence, consisting of 30 amino acids in a …

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Understanding Disparities In Hypertension Treatment Cascade And Validating Blood Pressure Measurement Among Persons Living With Or At Risk For Hiv, Jessica Blair Jan 2024

Understanding Disparities In Hypertension Treatment Cascade And Validating Blood Pressure Measurement Among Persons Living With Or At Risk For Hiv, Jessica Blair

All ETDs from UAB

In the United States, 44% of adult women >18 years have hypertension. Although non-Hispanic Black adults were more likely to be aware of and treated for hypertension compared to non-Hispanic White adults, Black individuals had the highest prevalence of uncontrolled hypertension. Persons living with HIV have a higher prevalence of hypertension, which is a major modifiable risk factor for cardiovascular disease. Similar to the geographic distribution of hypertension in the US, people living in the South have higher incidence of both hypertension and HIV diagnoses compared to other US regions. Furthermore, accurate diagnosis of hypertension and initiation of treatment is …

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Associations Of Religious Involvement And Cultural Justifications With Depressive Symptoms And Burden Among Caregivers, Maizonne Fields Jan 2024

Associations Of Religious Involvement And Cultural Justifications With Depressive Symptoms And Burden Among Caregivers, Maizonne Fields

All ETDs from UAB

With the advancement of medicine, life expectancy has increased globally. As a result, the need for a caregiver by an older adult has also risen. A caregiver is often a spouse, child, or friend of an older adult that assists an older adult that is experiencing changes in their ability to complete activities of daily living and/or instrumental activities of daily living. Caregivers are often unpaid for their assistance and can be at heightened risk for negative mental health outcomes. This study used the Stress Process Model to investigate the associations of high levels of religious commitment or involvement (RCI) …

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Shakespeare’S Tragic Heroines: Personality And Status Versus Gender, Ryann Grace Howard Jan 2024

Shakespeare’S Tragic Heroines: Personality And Status Versus Gender, Ryann Grace Howard

All ETDs from UAB

Readings of Shakespeare’s female characters as presentations of ideals – such as innocence – or as characters limited by the innate nature of their gender fail to understand the full personalities and challenges these characters have. The chosen characters are discussed in the pairings of Cordelia and Cleopatra (queens) and Desdemona and Juliet (high-status ladies) to show how this thesis’s chosen female characters are presented through their individual statuses and personalities rather than their genders.

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Mixed Martial Arts, Meaning, And Behavioral Peace: Examining Social Relationships In A Diverse Environment, Dana Dawson Jan 2024

Mixed Martial Arts, Meaning, And Behavioral Peace: Examining Social Relationships In A Diverse Environment, Dana Dawson

All ETDs from UAB

This thesis investigates the manifestation of behavioral peace within the diverse subcultures of mixed martial arts (MMA) gyms, drawing from the operational definition provided by peace ethology, which encompasses more than just the absence of violence. Peace ethology investigates how behavioral peace is achieved through mutual interests, tolerance, helping, sharing, and the avoidance of aggressive confrontation. This thesis explores how behavioral peace manifests in environments characterized by controlled violence and vulnerability, focusing on three MMA gyms in Alabama. Employing an ethnographic and ethological framework, the methodology blends autoethnography with participant observations and semi-structured interviews to comprehend the cultural, environmental, and …

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Physiologically Relevant Cardiac Tissue Chips For Cardiovascular Disease Modeling, Sachin Budhathoki Jan 2024

Physiologically Relevant Cardiac Tissue Chips For Cardiovascular Disease Modeling, Sachin Budhathoki

All ETDs from UAB

Despite significant advances in our understanding of the molecular basis of cardiovascular diseases (CVD) and the development of new therapeutics, it remains the number one cause of death worldwide, particularly affecting the aging population. This necessitates the development of models that can more accurately recreate aspects of aging and the interaction of the heart with other organs and systems in the body, including the immune system. Tissue chip models are being increasingly considered for studying cardiac diseases as they can potentially address translational hurdles associated with animal models, yet several challenges hinder their full potential. These include a lack of …

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Investigating Impacts Of Caregiving On Cognitive Function: Role Of Social Support, Lu Tian Jan 2024

Investigating Impacts Of Caregiving On Cognitive Function: Role Of Social Support, Lu Tian

All ETDs from UAB

Study Aim: Using the stress process model as a framework, this dissertation aims to investigate the role of social support on the influence of informal caregiving on cognitive function of caregivers aged 50 years and older and to look at potential gender and racial differences in this association. Method: Leveraging data from the 2016 to 2020 waves of the Health and Retirement Study (HRS), this research employs Ordinary Least Squares (OLS) regression analysis to examine the influence of caregiving on the cognitive function of older adults. To comprehensively understand the pathways through which caregiving impacts cognitive outcomes, I use mediation …

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Evaluation Of Feed Intake, Growth, And Reproduction In The Zebrafish, Danio Rerio, Fed A Gel-Based Diet, Thomas Logan Holfelder Jan 2024

Evaluation Of Feed Intake, Growth, And Reproduction In The Zebrafish, Danio Rerio, Fed A Gel-Based Diet, Thomas Logan Holfelder

All ETDs from UAB

EVALUATION OF FEED INTAKE, GROWTH, AND REPRODUCTION IN THE ZEBRAFISH, DANIO RERIO, FED A GEL-BASED DIET THOMAS LOGAN HOLFELDER BIOLOGY ABSTRACT The zebrafish, Danio rerio, is a valuable pre-clinical model, aiding human health understanding and translational aquaculture. Comprehensive documentation of the culture of this model exists, with ongoing efforts to optimize husbandry requirements, particularly in the areas of diet and nutrition. Labor or mechanical costs related to feeding are high in most laboratories and alternative protocols to reduce feed handling would be beneficial and could allow the capability to monitor feed consumption. A commercially produced gel-based diet has a high …

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Elementary School Administrators’ Preparedness In The Area Of Special Education Leadership: Implications For School Administrative Preparation Programs, Jeanette E. Wojcik Jan 2024

Elementary School Administrators’ Preparedness In The Area Of Special Education Leadership: Implications For School Administrative Preparation Programs, Jeanette E. Wojcik

Selected Full Text Dissertations, 2011-

This study explores the perceived preparedness of elementary school building leaders in special education leadership and its implications for school administrative preparation programs. This study aimed to address this problem by examining two research questions. The first was to investigate course offerings in administrative preparation programs in New York State (NYS) to better understand how many special education-specific classes are included in such programs. The second research question was to explore the extent to which public elementary school building leaders in Long Island, New York perceive their preparedness for managing special education issues related to their professional duties, staff, and …

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The Exclusion Of Black Girls: A Quantitative Study, Ursula Moorer Jan 2024

The Exclusion Of Black Girls: A Quantitative Study, Ursula Moorer

Selected Full Text Dissertations, 2011-

Existing research consistently indicates that Black girls are assigned disproportionately exclusionary disciplinary consequences such as, suspension and expulsion rates, surpassing their White counterparts and Black boys. According to the Report to Congressional Requesters, (United States Governmental Accountability Office, 2018), exclusionary discipline is any type of removal from a student’s normal educational setting. This quantitative correlational study examined the relationship between the racial demographics within a school's student and personnel populations and occurrences of suspensions faced by Black female students in grades 9 through 12. Archival data were used from the New York State Education Department (NYSED) website. NYSED data are …

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Implementation And Promotion Of Digital Citizenship In K-12 Schools: A Case Study Of Selected Schools On Long Island, New York, Seema Sumod Jan 2024

Implementation And Promotion Of Digital Citizenship In K-12 Schools: A Case Study Of Selected Schools On Long Island, New York, Seema Sumod

Selected Full Text Dissertations, 2011-

The advances in technology in the past decades have revolutionized the field of K-12 education, and its widespread implementation has given rise to the concurrent need to educate students about its responsible usage. The concept of digital citizenship as applicable to schools includes elements like digital access, digital communication, digital literacy, digital etiquette, digital rights and responsibilities and digital security. This study examined how twelve randomly selected school districts in the Long Island region of New York presented and promoted digital citizenship on their websites. A content analysis of these school district websites was conducted to identify which elements of …

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School Monitors: A Quantitative Study On The Support Needed For These Professionals, Sara Goldberg Jan 2024

School Monitors: A Quantitative Study On The Support Needed For These Professionals, Sara Goldberg

Selected Full Text Dissertations, 2011-

Minimal research has been focused on the role of school monitors in the public-school setting. This study explored the perspectives of school monitors on preparation, training, communication, and feedback. The study looked to examine if these aspects contribute to the overall role of school monitors and to identify specific areas where they require guidance and support to assist students throughout their day. Additionally, the study determined if schools who use a social emotional curriculum have school monitors who feel more supported in their role. Preparation, support, communication, and feedback was investigated using a 27 statement Likert-scale survey and three open-ended …

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Digital Transformations In The Hotel Industry, Mehmet Sanli Jan 2024

Digital Transformations In The Hotel Industry, Mehmet Sanli

Selected Full Text Dissertations, 2011-

New technologies are changing the way business is done in the hospitality industry. This research explores the emerging field of technology in the hotel industry. This research examines the significant influence of Information Communication Technology (ICT) in driving digital transformations in the hotel industry. With the evolution of the global hospitality sector, the in-corporation of advanced digital technologies has become essential for hotels aiming to elevate customer experiences, operational efficiency, and overall competitiveness. The research observes key components of digital transformation in the hotel industry, including but not limited to online booking systems, mobile applications, data analytics, the Internet of …

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Financial Accessibility And Academic Outcomes: A Comparative Study Of First-Year Pell Grant Recipients At Urban And Suburban Private Four-Year Colleges, Ilkania Maldonado Jan 2024

Financial Accessibility And Academic Outcomes: A Comparative Study Of First-Year Pell Grant Recipients At Urban And Suburban Private Four-Year Colleges, Ilkania Maldonado

Selected Full Text Dissertations, 2011-

Students’ financial literacy and academic success are essential determinants of their ability to offer socio-economic value and afford college. One of the burning concerns in college education for years has been the differences in the funding difficulties that students experience based on whether the college is located in an urban or suburban setting. This quantitative study focuses on the difference in graduation rates of Pell-eligible first-time students enrolled in private four-year institutions in urban areas compared to suburban areas. Focusing mainly on urban and suburban environments, the investigation is mainly concerned with understanding the role of locations of universities in …

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2. Prospero Overview, John Pender, Perry Share Jan 2024

2. Prospero Overview, John Pender, Perry Share

Irish Journal of Applied Social Studies

No abstract provided.

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3.Ethical Complexities Within The Appearance And Usage Of Social Robots: A Scoping Review, Mads Lund Anderson, Heike Felzmann Jan 2024

3.Ethical Complexities Within The Appearance And Usage Of Social Robots: A Scoping Review, Mads Lund Anderson, Heike Felzmann

Irish Journal of Applied Social Studies

No abstract provided.

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4. Robotic Babies - Data, Didactics And Ethics In Social Work, Mads Lund Andersen, Vivi Friis Søgaard, Karin Christiansen, Heike Felzmann, Almundena Navas, Miriam Abietar Jan 2024

4. Robotic Babies - Data, Didactics And Ethics In Social Work, Mads Lund Andersen, Vivi Friis Søgaard, Karin Christiansen, Heike Felzmann, Almundena Navas, Miriam Abietar

Irish Journal of Applied Social Studies

No abstract provided.

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6.Can Social Robot Teaching Assistants Innovate The Irish Primary Education System, John Pender, Debbie Woodward Jan 2024

6.Can Social Robot Teaching Assistants Innovate The Irish Primary Education System, John Pender, Debbie Woodward

Irish Journal of Applied Social Studies

No abstract provided.

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7. Practice Report: Social Robots Help Social Clients Become More Independent And Creates New ‘Client-Professional’ Relations, Hans Jørgen Niewald, Maria Bisgaard Fabricius, Mette Toft Jan 2024

7. Practice Report: Social Robots Help Social Clients Become More Independent And Creates New ‘Client-Professional’ Relations, Hans Jørgen Niewald, Maria Bisgaard Fabricius, Mette Toft

Irish Journal of Applied Social Studies

No abstract provided.

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