Digital Commons Network^™

Structure Of Ergosteryl-Aspartate Synthase Reveals How An Entrapped Trna Is Used Like A Prosthetic Swinging Arm In The Synthesis Of Aminoacylated Sterols, Hanako Murayama, Nathaniel Yakobov, Nassira Mahmoudi, Sasha Legrosdidier, Nicolas Fournier, Solène Zuttion, Kanata Matsumoto, Michihiro Nishimura, Jingwei Ji, Bruno Senger, Laurence Huck, Howard Gamper, Yoshiaki Kise, Ralph Kleiner, Mathieu Frechin, Ya-Ming Hou, Hubert Becker, Yuzuru Itoh, Frédéric Fischer, Osamu Nureki

Department of Biochemistry and Molecular Biology Faculty Papers

Ergosteryl-3β-O-L-aspartate synthase (ErdS) catalyzes tRNA-dependent aspartylation of ergosterol, a lipid essential for fungal cell membrane integrity. However, the functional significance of ergosteryl-aspartate and the molecular mechanisms underlying its synthesis remain unclear. Here, we show that ErdS localization is highly dynamic and that Erg-Asp is required for proper hyphal growth, sporulation, and spore germination, and likely influences stress tolerance. The cryo-electron microscopy structure of ErdS revealed an unprecedented sterol-binding pocket. In addition, the structures in complex with a non-hydrolyzable Asp-N-tRNAAsp show a tRNA-guided intramolecular aminoacyl transfer mechanism between two functional domains of the enzyme. The CCA end of tRNAAsp undergoes a …

Pregnancy Outcomes After In Utero Exposure To Immune Checkpoint Inhibitors, Morgan Bou Zerdan, Bruna Kfoury, Eliane Aoun, Sarah Diane Hmaidan, Roni Nitecki Wilke, Jeffrey A How, Terri L Woodard, Pamela T Soliman, Laurie J Mckenzie

Faculty, Staff and Students Publications

Importance: Immune checkpoint inhibitors (ICIs) have transformed the management of cancers affecting reproductive-age patients, yet their impact on pregnancy outcomes remains incompletely understood. We describe two cases of maternal and fetal outcomes associated with ICI exposure during pregnancy and present a comprehensive literature review.

Methods: A retrospective chart review was conducted at MD Anderson Cancer Center (1 January 2015 to 31 December 2024) to identify patients exposed to ICIs during pregnancy. Clinical data including cancer type, treatment timing, pregnancy course, and maternal and neonatal outcomes were collected. A narrative literature review was also performed using PubMed to identify reported cases …

The 2026 Fifa World Cup: Communicable Disease Risks And Advice For Visitors To Canada, The United States, And Mexico, Alfonso J Rodriguez-Morales, Ivan Arturo Rodríguez-Sabogal, Beatriz Elena Porras-Pedroza, Álvaro A Faccini-Martínez, Daniel Grisales-Nieto, Florencia Escarrá, Pasesa Pascuala Quispe-Torrez, Francisco Javier Membrillo, Tomás Orduna, Susana Lloveras, Tânia S S Chaves, Miguel M Cabada, Cecilia Perret, René Echavarría, Ana F Ribeiro, Melinda Tanabe, Fernando Bazzino, Maximiliano Ramirez, Baruch Diaz, Karen Mirna Loro Morejón, Karen Daly, Reinaldo Rosas, Maria Belen Lopez, Cristina Miranda, Marisa Liliana Fernandez, Yasemin Özsürekçi, Wasin Matsee, Yenddy Carrero, Cristian Biscayart, Sergio Cimerman, Maria L Avila-Aguero, Roberto Debbag, Jose Brea, Alejandro Risquez, Jaime David Acosta-España, Rolando Ulloa-Gutierrez, Carlos Espinal, Carlos N Torres-Martinez, Marta González-Sanz, Aula Abbara, Jill Weatherhead, Mario Masana

Faculty, Staff and Students Publications

No abstract provided.

Unbiased Niche Labeling Maps Immune-Excluded Niche In Bone Metastasis, Zhan Xu, Fengshuo Liu, Yunfeng Ding, Tianhong Pan, Yi-Hsuan Wu, Yujiao Han, Jun Liu, Igor L Bado, Weijie Zhang, Ling Wu, Yang Gao, Xiaoxin Hao, Liqun Yu, Xuan Li, David G Edwards, Hilda L Chan, Sergio Aguirre, Michael Warren Dieffenbach, Elina Chen, Siyue Wang, Yichao Shen, Dane Hoffman, Luis Becerra Dominguez, Charlotte Helena Rivas, Xiang Chen, Hai Wang, Yibin Kang, Zbigniew Gugala, Robert L Satcher, Xiang H-F Zhang

Faculty, Staff and Students Publications

Metastatic cancer cell fate is shaped by the local microenvironment niches. To unbiasedly define the cellular and molecular features of metastatic niches, we developed sortase A-based microenvironment niche tagging (SAMENT), which selectively labels cells encountered by cancer cells during metastasis. Applying SAMENT across multiple cancer models and target organs revealed shared niche features, including macrophage enrichment and T cell depletion, alongside marked organ-specific phenotype heterogeneity in niche macrophages. In bone, metastatic niches are enriched for macrophages expressing estrogen receptor alpha (ERα) with active ERα signaling. Conditional deletion of Esr1 in macrophages significantly impaired bone colonization by enabling T cell infiltration. …

Applicability Of Diatom Indices And Phytoplankton Functional Groups To Assessment Of Water Quality In The Coastal Egyptian Mediterranean Estuary, Fatma A. Zaghloul, Soha H. Shabaka

Blue Economy

This study provides the first application of diatom-based water quality and eutrophication assessments in Egypt, focusing on the El Mex Bay situated along the Mediterranean Coast of Egypt, providing a comprehensive evaluation of how diatom assemblages can serve as reliable bioindicators for ecological monitoring in this heavily impacted coastal system. It analyzes two distinct periods: monthly from 2003-2004 and seasonally from 2020-2021. Diatom community composition shifted significantly between the two decades. The earlier period hosted 109 diatom species, which declined to 69 species in the later period. Concurrently, overall abundance decreased from 1,071 x 10³ to 728 x 10³ cells/L. …

From Double Absence To Double Presence: Video-Selfie As Empowerment In A Multicultural Italian Classroom, Maria Ranieri, Ilaria Bucciarelli, Giulia Cuozzo

Journal of Media Literacy Education Pre-Prints

This paper examines the video-selfie as a tool for empowerment in multicultural secondary school classrooms. We draw on data from the European ICME project, focusing on a vocational secondary school in Italy, where 17 of 18 first-year students – approximately half of whom had migration backgrounds – produced short videos presenting themselves through personally meaningful objects. Students then participated in a structured reflection activity after watching each other's videos in class. We combine three theoretical frameworks: critical media literacy, identity and self-representation studies, and Mezirow's transformative learning theory. Our argument is that the video selfie empowers in multiple ways: it …

The Relationship Between Synchronous Online Training Preference And Online Student Engagements, Saida Ulfa, Rex Bringula

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

Online training during the pandemic was commonly held using the synchronous learning method. The aim of this study was to explore the relationship between synchronous online training preference, gender difference, and online student engagements (OSE). This study was analyzed with Structural Equation Model (SEM) by using SmartPLS 3 software. The participants of this study involved 35 online training participants and produced the following findings (1) synchronous online training preference has a positive relationship with OSE variables, (2) The relationship between OSE variables is positive, (3) a gender has a positive relationship with skills, participation, and performance, while gender has a …

Developing Scientific Article Writing Materials Using A Hybrid Learning Approach: Insights From An Indonesian Language For Foreign Speakers (Bipa) Program, Ah. Rofiuddin, Didin Widyartono, Gatut Susanto, David Pickus

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

This study aims to develop learning materials for writing scientific articles for international students using the hybrid learning approach. This approach was chosen by utilizing the advantages of offline classes combined with online classes. This approach is in accordance with the characteristics of students as millennials. For product development, we used a method consisting of product design, product design, production, and product testing. In the end, we produced learning materials to write scientific articles packaged in the form of a module of writing process-genre-based scientific articles with a hybrid learning approach for international students. The module consists of the debriefing …

Mapping Arabic Calligraphy Education Research Structure: A Bibliometric Analysis Between 2016 And 2021 Using Vosviewer, Nurul Murtadho, Mohammad Dawood

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

The purpose of this study is to present a bibliometric analysis of Arabic calligraphy research from the Scopus database from 2016 to 2021. This study identified 43 English documents for further analysis based on the query used and the document screening stages. In this study, Vosviewer was used to visualize the data, and Harzing's Publish or Perish is used to harvest data, calculate metrics, and analyze citations. According to our findings, Arabic calligraphy research publications are increasing, with the peak occurring in 2019, including in terms of citations. The findings indicate that research in language and arts is closely related …

Kesiapan Dan Motivasi Mahasiswa Dalam Mengikuti Pembelajaran Online Di Masa Pandemi Covid-19, Nur Indrianti, Ellen Chung, Ammar Hamid Adil

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

This study aimed to determine online learning readiness, motivation, and challenges for students in Indonesia during the COVID-19 pandemic. Aspects considered in this study included supporting devices and skills to use them, independence in learning, self-control for successful learning, learning motivation, and online communication. The study was conducted using an online questionnaire and crosstabs analysis. The results showed that the students had a good readiness and motivation to do online learning during the pandemic. The most common obstacles included internet connection, limited data quota, unsupported devices, and lecturer learning methods.

The Effect Of Technological Literacy, Learning Facility, And Family Environment On Students’ Learning Motivation, Agung Winarno, Maria Yorozi Andini Fedin, Norlida Hanim Mohd Salleh

Jurnal Pendidikan: Teori, Penelitian, dan Pengembangan

Student achievement is influenced by a variety of factors, both internal and external, such as school and home amenities. This study intends to assess the effect of technological literacy, amenities and learning environment on the learning motivation of SMK students during the pandemic. This is a quantitative Expos-Fact style of study. This study's population and sample consisted of 58 students majoring in Automation and Office Governance at SMK PGRI Turen; questionnaires and observations were used to collect data. Multiple linear regression test was employed for data analysis. The analysis reveals that technical literacy has a favorable influence on learning motivation, …

Hidden In Plain Sight: The Role Of Belonging In Shaping Pre-Service Teachers’ Motivations & Practices In A Paraprofessional-To-Teacher Pathway, Julie Sidarous Dr., Douglas Van Dyke Dr.

i.e.: inquiry in education

As school districts face persistent teacher shortages, paraprofessionals and school staff remain an untapped resource with immense potential. The purpose of this study was to explore the distinct benefits that school employees bring to the teaching profession when transitioning into roles as teachers of record. To deeply understand candidates' stories, this qualitative study employed Interpretive Phenomenological Analysis (IPA) to examine how preservice teacher candidates make sense of their own lived experiences. The findings reveal five key advantages these transitioning educators provide: deep community connections, practical institutional knowledge, resilience in high-need schools, expertise supporting non-traditional learners, and a profound desire to …

Belonging As The Bedrock Of Learning, Gloria Mcdaniel-Hall, Nina Weisling

i.e.: inquiry in education

The reasons why we teach are intensely personal. We give our hearts and souls to “the work,” though it is so much more than work to us. It is a calling, felt deep in our souls, to correct wrongs, to bend the “arc of the moral universe” all the way to justice, to realize the dreams that have been deferred at best and stamped out and denied at worst. Because at the core of each day, we find humans, students, families, and colleagues who are inherently worthy of learning, loving, and living a fulfilling life. Yet, for far too many …

Teachers’ Action Research Knowledge: From Knowing To Doing, Firdissa J. Aga Dr.

i.e.: inquiry in education

This quantitative study investigated the action research (AR) knowledge of English as a Foreign Language (EFL) instructors at three Ethiopian public universities. Data collected via questionnaire from 57 instructors revealed that EFL instructors had respectively high and medium theoretical and practical knowledge of AR. Their theoretical knowledge and practical skills demonstrated a significant positive correlation (r = 0.43, p < 0.01). Furthermore, instructors’ preferences showed strong alignment with reflective rationality (context-specific, practitioner-led inquiry) over technical rationality (externally imposed, top-down approaches). While reported levels of reflection-on-action and reflection-in-action were high, tacit knowing-in-action-the deep, personal, often unarticulated professional knowledge-was notably low. This gap suggests that instructors’ AR understanding remains largely externalized, not yet internalized as embodied, intuitive practice. The findings suggest that empowering instructors to convert their tacit knowledge into explicit understanding through sustained, hands-on AR engagement is critical for authentic professional development and transformative classroom practice.

Applying The Framework Of Activity Theory As An Ongoing Complementary Planning And Evaluation Tool For Esl/Bilingual Programs. How To (Meet) And Go Beyond Compliance, Margaret Bouchard, Jason Stegemoller

i.e.: inquiry in education

In this conceptual article, the authors explore the use of Activity Theory as a tool to build a framework for designing, modifying, or evaluating ESL/Multilingual Programs. Demographics of immigrant and emerging multilingual students within educational systems are continually evolving. Educational systems with emerging multilingual students are particularly vulnerable to this phenomenon and must meet changing needs that are often driven by outside influences. These changes might include: increases in immigration from varying student ethnicities, societal/political trends, socio-economic level of a community, legal regulations, and advanced educational research. Designing and evaluating educational programs within a system of change can be a …

Ai Need Not Make One Slothful, Roy A. Kaelin Jr

i.e.: inquiry in education

As National Louis University seeks to plan and advance its way amid the potential perils and pitfalls of so-named artificial intelligence, one finds that with reasonable workflows and guard rails, the use of AI proposes both potential promise and prospect, to assist and augment the natural intelligence that students and teachers bring to the classroom, encouraging them to pursue STEM-related activities with the preparation and deployment of focused and directed AI-bots. This paper presents examples and a case study of that directed and focused approach, the incremental lessons learned to date, and a proposed path to advance worthwhile AI …

Living With Ai Within The Context Of Higher Education, Terry Jo Smith

i.e.: inquiry in education

This autoethnographic study examines how generative AI has entered higher education, reshaping teachers’ and students’ inner lives, relational practices, and institutional ecologies. Drawing on the author’s embodied experiences within the higher education landscape, the analysis consists of plugging in theory, research, policy, and current events as a means to connect individual experience with broader concepts, events, and structures (Jackson & Mazzei, 2022). The paper maps affective responses such as awe and anxiety, pedagogical tensions such as assessment, transparency, and trust, and political-economic drivers such as capitalism and policy. The study foregrounds methodological reflexivity, arguing that critical autoethnography can surface situated …

Exploring Ai In Higher Education: Reflections On Research-Informed Practices For Teaching And Learning, Angela Elkordy, Stuart I. Carrier, Jack Denny, Donna Wakefield, Ayn F. Keneman

i.e.: inquiry in education

This article examines how faculty at a college of education are integrating generative AI tools into graduate and doctoral educator preparation programs. Drawing on faculty inquiry and course-based observations across multiple contexts — including early childhood education, secondary education, special education, and doctoral programs in education — the article synthesizes emerging lessons and practices of  AI literacy development, pedagogical approaches, and instructional design. We present an evidence-informed, reflective account of faculty practice through the lens of the scholarship of teaching, exploring how educators are navigating AI content, literacy, and practices in real courses, what students are learning, and what instructional …

Ai-Powered Remixes: Using Generative Ai To Critically Examine Text, Genre, And Language In First Year College Writing, Lauren Anderson, Eric Vandemark

i.e.: inquiry in education

As generative AI tools become embedded in writing instruction, educators face urgent questions about how these technologies encode and reinforce language standardization — particularly for multilingual and multidialectal students. This practitioner reflection describes a series of AI-powered "remix" activities developed and refined in corequisite writing labs. Building on a prior action research study, this paper turns to the pedagogical questions that emerged after the study: how AI tools might be used not as writing shortcuts but as objects of critical inquiry. Drawing on frameworks including critical literacy, plurilingualism, culturally relevant pedagogy, and AI literacy, we describe four remix activity types …

Scaffolded Generative Ai In Instructional Planning: Supporting Teacher Candidates’ Culturally Responsive Teaching, Dr. Eun Kyung Ko, Xiaoning Chen, Vishodana Thamotharan, Julie Sidarous

i.e.: inquiry in education

As generative artificial intelligence (GenAI) becomes increasingly embedded in instructional planning, teacher education programs must move beyond efficiency-oriented adoption toward equity-centered, pedagogically grounded integration. This mixed-methods longitudinal study examines a year-long, scaffolded approach to integrating GenAI within an early childhood teacher residency program, with a specific focus on culturally responsive teaching (CRT) instructional planning. Guided by the AI/I-TPACK and CRT frameworks, fourteen bilingual teacher candidates (TCs) participated in this study. Data sources included pre- and post-surveys of CRT self-efficacy, lesson plans and instructional artifacts, reflective coursework, and focus group interviews. Quantitative analyses revealed statistically significant gains in TCs’ CRT self-efficacy …

When The Output Looks Like Learning: Tertiary Algorithmicity, Unproductive Success, And The Case For Pedagogical Friction In K–12 Schools, Micah J. Miner

i.e.: inquiry in education

The rapid adoption of generative artificial intelligence in K–12 schools has outpaced educators' capacity to evaluate its effects on learning. This conceptual article argues that the dominant institutional responses treating AI as either an integrity threat or a productivity tool share an unexamined assumption that the fundamental nature of learning remains unchanged. Drawing on Walter Ong's media ecology and extending it through the concept of tertiary algorithmicity, the article offers a theoretical framework for understanding generative AI as a qualitative shift in the symbolic environment of schooling. For the first time, the prevailing communication technology ctively generates symbolic content, enabling …

Making Ai An Intelligent Tool For Our Schools: Using The Perceptions Of Administrators And Teachers In A Midwestern School District To Help Shape Our Educator Preparation Program, John A. Huss

i.e.: inquiry in education

This qualitative practitioner research study explored the attitudes and perceptions of administrators and teachers in a high-performing Midwestern school district regarding the integration of artificial intelligence (AI) in K-12 education. While AI has rapidly emerged as a transformative force in society, its implementation in schools remains inconsistent, with limited policies, training, and usage. Semi-structured interviews with nine educators (three principals and six experienced teachers) revealed widespread interest in AI, but also significant uncertainty and uneven adoption. Educators reported using AI for administrative and instructional tasks, such as grading and resource generation, yet expressed concern over student overreliance and diminished critical …

Dynamic Gateway Assignment For A Programmable Core In Any-G Networks, Anthony Maswan Fajri, Anders Askerup

Defensive Publications Series

Described herein is a Session Management Function Management Function (SMF-MF) that can provide a unified, intelligent system for optimizing performance across Any-G networks. By leveraging subscriber-level data and real-time network analytics, the SMF-MF can enable AI-driven load balancing and seamless session management while significantly reducing signaling overhead. The disclosed architecture may provide a centralized and future-ready approach to gateway selection that bridges operational differences between Long-Term Evolution (LTE) and Fifth Generation (5G) environments.

Food, Crisis And Hope: Three Conflicts, Three Approaches, Johanna Mendelson Forman, Michael Shaikh, Joan Nathan, Yeheniia Yemshenetska, Andrea Borghini

Dublin Gastronomy Symposium

Plenary Session: Food, Crisis and Hope: Three Conflicts, Three Approaches

Panel hosted by Johanna Mendelson Forman

Michael Shaikh - "Saving Cuisine Is the Same As Saving a People"

Joan Nathan - "The Edible DNA: Jewish Food as a Bond through Crisis and War"

Johanna Mendelson Forman and Yevheniia Yemshenetska - "Hope and Crisis in War: Ukraine’s Deployment of Food as Soft Power during Conflict"

Andrea Borghini - "Food in Times of Crisis: A Leadership Perspective"

Originalisms' Indifferences?: Friendly Amendments To Professor Girgis's "Originalism's Difference?", Jed Handelsman Shugerman

Florida Law Review

In this Essay, the author begins by summarizing their many areas of agreement with Girgis’s Dunwody Lecture, Originalism’s Difference?. Then they turn to each of Girgis’s three differences to ask a question and perhaps pose a critique. Has Girgis placed too much emphasis on “constraint”? Is “intensity” a virtue without sufficient care, balance, and open-mindedness, and perhaps a vice if it is a tendentiously intense control-f search? Is avoiding “palpable” moral reasoning a virtue if the Court is using historical evidence to cover for ideological motives and cognitive biases? This Essay turns to some of Girgis’s own examples of …

Originalism's Difference?, Sherif Girgis

Florida Law Review

This Article is a Dunwody Distinguished Lecture in Law and the topic is whether originalism makes any practical difference to constitutional reasoning and outcomes, relative to other methods of interpretation.

Does Good Originalism Need Good History?, Gary Lawson

Florida Law Review

One might think that originalism by definition is largely about history. After all, what does it mean to be “originalist” if not to be concerned primarily, if not exclusively, about the past? And if history is relevant, surely good history is better than bad history?

That seemingly obvious conclusion is not actually obvious. The role of good history, as with the role of any discipline—be it linguistics, epistemology, economics, classical studies, or political theory—depends on what questions one asks. And at least some forms of originalism ask questions for which the role of good history, as historians might define good …

Complete Issue-Volume 14, Issue 1, Edwin A. Miles

Journal of Mississippi History

No abstract provided.

Franklin E. Plummer: Piney Woods Spokesman Of The Jackson Era, Edwin A. Miles

Journal of Mississippi History

No abstract provided.

Rethinking Pre-Service Teachers’ Agency In Ai-Supported Lesson Design Through A Posthuman Synthesis Of Three Empirical Studies In Teacher Education, Wen Wen, Huijing Wen

Excelsior: Leadership in Teaching and Learning

Generative artificial intelligence (GenAI) is increasingly used in lesson planning in teacher education. There has been a growing interest in exploring the different practices of teachers using GenAI to support lesson planning. This conceptual paper, using posthumanism as a framework, synthesizes three empirical studies to conceptualize pre-service teachers’ agency in AI-supported lesson design on literacy instruction. Pre-service teachers’ agency emerges from the interaction with GenAI, as well as with other human and non-human resources. Although their agency is shared and distributed during the design process, it remains essential for pre-service teachers to actively exercise their agency and make informed judgments …