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Design And Synthesis Of Substituted 1,4-Hydrazine-Linked Piperazine-2,5- And 2,6-Diones And 2,5-Terpyrimidinylenes As Α-Helical Mimetics, Laura Anderson Jul 2009

Design And Synthesis Of Substituted 1,4-Hydrazine-Linked Piperazine-2,5- And 2,6-Diones And 2,5-Terpyrimidinylenes As Α-Helical Mimetics, Laura Anderson

USF Tampa Graduate Theses and Dissertations

The most common secondary structure of proteins is the alpha-helix. The alpha-helix can be involved in various protein-protein interactions (PPIs) through the recognition of three or more side chains along one face of the alpha-helix (Wells and McClendon, 2007). In recent years, there has been an increasing interest in the development of peptidic and non-peptidic compounds that bind to PPI surfaces. We focused on the design and synthesis of compounds that mimic the orientation of side chain residues of an alpha-helical protein domain. Although our scaffolds could potentially inhibit various PPIs, we focused mainly on the disruption of interactions among …

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The Use Of Fourier Transform (Ft) Surface-Enhanced Raman Scattering For Biochemical Analysis, Robert Butler Jeffers Jul 2009

The Use Of Fourier Transform (Ft) Surface-Enhanced Raman Scattering For Biochemical Analysis, Robert Butler Jeffers

Chemistry & Biochemistry Theses & Dissertations

Surface-enhanced Raman scattering (SERS) is a powerful spectroscopic technique that has created exciting opportunities in the field of bioanalytical chemistry, where it combines ultrasensitive detection of biologically relevant molecules with vibrational spectroscopy. Due to the difficulties in preparing reproducible SERS active substrates, SERS has been mainly used as a qualitative tool. In order for SERS to be utilized as a viable tool for quantitative analysis, simple, facile SERS substrates which generate clean, highly reproducible signals must be developed. This dissertation deals with the evaluation of three different methods of SERS that led to the development of a novel substrate for …

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The Effect Of Prior Knowledge In Undergraduate Performance In Chemistry: A Correlation – Prediction Study, Michael K. Seery Jul 2009

The Effect Of Prior Knowledge In Undergraduate Performance In Chemistry: A Correlation – Prediction Study, Michael K. Seery

Theses

No abstract provided.

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What Happens To Student Engagement And Understanding Of Chemistry When Cross-Curricular Activities And Assignments Are Used In An Honors Chemistry Class?, Heather L. Keller Jun 2009

What Happens To Student Engagement And Understanding Of Chemistry When Cross-Curricular Activities And Assignments Are Used In An Honors Chemistry Class?, Heather L. Keller

Theses and Dissertations

The focus of this action research study was to determine if cross-curricular learning strategies could be used in a chemistry class to increase both student engagement and understanding of chemistry content. Two strategies were implemented in an honors chemistry course of sophomores and juniors. Participants were chosen on a voluntary basis, those students who chose not to participate still needed to complete the activities, however, their grades and responses were not included in the data. Participating students were required to complete a consent form and obtain parental permission. Students completed a creative writing activity and a kinesthetic activity in which …

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Mole Street Journal, June 2009, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry Jun 2009

Mole Street Journal, June 2009, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry

Mole Street Journal

No abstract provided.

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Web Based Classes For Enhancement Of Prelaboratory Lectures, Tiffany Hesser, Michael Collura Jun 2009

Web Based Classes For Enhancement Of Prelaboratory Lectures, Tiffany Hesser, Michael Collura

Chemistry and Chemical Engineering Faculty Publications

The use of web classes, such as Tegrity Campus1, as a supplement to pre laboratory reading or a replacement for pre laboratory lectures could become a standard tool in laboratory education protocol. In classes with multiple lab sections and instructors, pre laboratory lectures can lack consistency and it can be difficult to gauge the students’ level of preparation. With the ever increasing exposure to technology, students generally prefer information in a digital and multimedia form, rather than textbook readings. Therefore, this method can prove to better prepare students prior to laboratory experiments, increasing the overall understanding of the chemical reactions …

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Risk Assessment And Risk Management Of Nano-Material Toxicity, Farah Bigdeli May 2009

Risk Assessment And Risk Management Of Nano-Material Toxicity, Farah Bigdeli

LSU New Orleans Theses and Dissertations

Increasing applications of nano materials in medicine, construction, textiles, computers, and other consumer goods have lead to increasing concerns of their effect on human health and ecology during synthesis, manufacturing, use, and disposal of nano-materials. Though much scientific progress has been made in nano material synthesis, manufacturing, and application in consumer goods and other sectors such as medicine, textiles and more, not much progress has been made in understanding the adverse effects of nano materials on human health and the environment. Physical, chemical, toxicological characteristics of these nano materials and their fate in the environment are important in understanding their …

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Asymmetric Synthesis Of Sl0101, Cyclitol And Jadomycin, Mingde Shan May 2009

Asymmetric Synthesis Of Sl0101, Cyclitol And Jadomycin, Mingde Shan

Graduate Theses, Dissertations, and Problem Reports (ETD)

The carbohydrate portion of natural products plays a crucial role in biology, such as target binding, solubility, tissue targeting, and membrane transportation. The O'Doherty group has developed a de novo methodology to build the desired functionality and stereochemistry within each sugar, in contrast to the traditional approach using known carbohydrates as starting materials. This methodology relies on a highly diastereoselective palladium(0)-catalyzed glycosylation reaction to control the stereochemistry at the anomeric center and post-glycosylation transformation to introduce the corresponding functionality in the sugar moiety.;Continuing our investigations on the utility of this strategy, we turned our attention to the syntheses of the …

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Anthropogenic Osmium In Rain And Snow Reveals Global-Scale Atmospheric Contamination, Cynthia Chen, Peter N. Sedwick, Mukul Sharma May 2009

Anthropogenic Osmium In Rain And Snow Reveals Global-Scale Atmospheric Contamination, Cynthia Chen, Peter N. Sedwick, Mukul Sharma

Dartmouth Scholarship

Osmium is one of the rarer elements in seawater, with typical concentration of approximately 10 x 10(-15) g g(-1) (5.3 x 10(-14) mol kg(-1)). The osmium isotope composition ((187)Os/(188)Os ratio) of deep oceans is 1.05, reflecting a balance between inputs from continental crust (approximately 1.3) and mantle/cosmic dust (approximately 0.13). Here, we show that the (187)Os/(188)Os ratios measured in rain and snow collected around the world range from 0.16 to 0.48, much lower than expected (>1), but similar to the isotope composition of ores (approximately 0.2) that are processed to extract platinum and other metals to be used primarily …

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Mole Street Journal, May 2009, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry May 2009

Mole Street Journal, May 2009, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry

Mole Street Journal

No abstract provided.

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Mole Street Journal, April 2009, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry Apr 2009

Mole Street Journal, April 2009, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry

Mole Street Journal

No abstract provided.

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Utpa Commencement – Spring 2009, University Of Texas-Pan American Apr 2009

Utpa Commencement – Spring 2009, University Of Texas-Pan American

Edinburg Archives - Legacy Commencement Programs

No abstract provided.

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Mole Street Journal, March 2009, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry Mar 2009

Mole Street Journal, March 2009, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry

Mole Street Journal

No abstract provided.

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Mole Street Journal, February 2009, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry Feb 2009

Mole Street Journal, February 2009, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry

Mole Street Journal

No abstract provided.

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Mole Street Journal, January 2009, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry Jan 2009

Mole Street Journal, January 2009, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry

Mole Street Journal

No abstract provided.

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Evidence Of Infaunal Effects On Porewater Advection And Biogeochemistry In Permeable Sediments: A Proposed Infaunal Functional Group Framework, George G. Waldbusser, Roberta L. Marinelli Jan 2009

Evidence Of Infaunal Effects On Porewater Advection And Biogeochemistry In Permeable Sediments: A Proposed Infaunal Functional Group Framework, George G. Waldbusser, Roberta L. Marinelli

Journal of Marine Research

Bioturbating infauna significantly modify reaction and transport processes in permeable sediments, though most studies to date are limited in the scope of species examined. We conducted a comparative field study measuring density-dependent effects of six common bioturbating species on porewater advection and biogeochemistry, across three intertidal permeable sediment habitats. The species in this study are; head-down like deposit feeders (Abarenicola pacifica and Balanoglossus aurantiacus), surface deposit feeders (Diopatra cuprea and Onuphis jenneri) and gallery diffusers (Upogebia pugettensis and Neotrypaea californiensis). Tracer loss from gel diffusers was used to assess relative differences in porewater advection …

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A Reconnaissance Of The Intersex Condition In Micropterus Dolomieu Of The Upper Ohio River Basin As An Indicator Of Anthropogenic Endocrine Disruptors, Christopher Barry Jan 2009

A Reconnaissance Of The Intersex Condition In Micropterus Dolomieu Of The Upper Ohio River Basin As An Indicator Of Anthropogenic Endocrine Disruptors, Christopher Barry

Theses, Dissertations and Capstones

The intersex condition has been used as a marker of endocrine disruption in West Virginia. Fifty-two male smallmouth bass from 6 basins on the upper Ohio River were examined for the presence and severity of intersex. Vitellogenin (VTG) RNA levels were quantified as marker of estrogenic contaminants. A significant increase in intersex (p=0.02), ranging from 83.3% to 100%, corresponds with higher population densities and agricultural land (p=0.003). At reference sites, smallmouth bass had intersex frequencies of 16.7% to 33.3%. Vitellogenin results were significantly lower (p< 0.001) at impacted sites, consistent with previously reported results in female fish. VTG levels in males were not significantly different. Increased intersex occurrence in males and lowered VTG expression in females have shown that agricultural chemicals and common residential wastewater constituents are likely targets for exploring the relationship between individual EDCs and intersex. There may be a natural background level of the intersex condition.

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Ua58/1 Graduate Studies & Research - Theses & Dissertations, Wku Archives Jan 2009

Ua58/1 Graduate Studies & Research - Theses & Dissertations, Wku Archives

WKU Archives Collection Inventories

Inventory of theses and dissertations written by WKU students housed in WKU Archives. Theses and dissertations for the period 1932-present are digitized and available in TopScholar, WKU’s Institutional Repository, except where the author denied permission. These are available with limited access. Digitized theses include url.

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Use Of Urokinase In The Treatment Of Tuberculous Meningitis Hydrocephalus, Mutasem M. Abuhamed, Song Zhi, Xiao Bo Jan 2009

Use Of Urokinase In The Treatment Of Tuberculous Meningitis Hydrocephalus, Mutasem M. Abuhamed, Song Zhi, Xiao Bo

Neurosciences

We present a patient with hydrocephalus after tuberculous meningitis successfully treated with urokinase. She presented with multiple episodes of headache, fever, and vomiting. She underwent external ventricular drainage and was treated with urokinase in addition to dexamethasone, acetazolamide, and 4 antituberculous drugs. She was evaluated clinically, radiologically, and by laboratory work-up. On short-term clinical follow-up (3 months), she was asymptomatic after the treatment with urokinase. She was radiologically evaluated 3 weeks after the treatment. An MRI of the brain showed a decrease in ventricular size. Urokinase can be considered as a safe and promising adjunctive treatment for tuberculous meningitis hydrocephalus.

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Proceedings Of The South Dakota Academy Of Sciences, 2009, Volume 88., South Dakota Academy Of Science Jan 2009

Proceedings Of The South Dakota Academy Of Sciences, 2009, Volume 88., South Dakota Academy Of Science

Proceedings of the South Dakota Academy of Science

Proceedings of the South Dakota Academy of Science, 2009, Volume 88. The Proceedings includes the consolidated minutes of the ninety-fourth annual meeting of the South Dakota Academy of Science, held April 3–4, 2009. This volume features a special symposium titled Year of Science, the complete senior research papers, and abstracts presented during the meeting. The presidential address, titled Examining South Dakota Academy of Science’s Roles in the Scientific Landscape of South Dakota, was delivered by Krisma D. DeWitt. Special Symposium: Year of Science 2009: The Year of Science: Public Understanding of Science by Charles R. Berry, Jr.; Preparing a Scientifically …

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Method Against Method: Swarm And Interdisciplinary Research Methodology, Dylan E. Wittkower Jan 2009

Method Against Method: Swarm And Interdisciplinary Research Methodology, Dylan E. Wittkower

Philosophy Faculty Publications

Part of a special issue on “swarm methodology,” this paper, written by a swarm participant, reflects upon the purpose and value of this kind of interdisciplinary research methodology. First, by way of a recognition of the interdisciplinary status of this paper itself, the question of what we hope to accomplish when we engage in conversations across disciplinary boundaries is broached. Second, a discussion of the practice of peer-review provides an approximate view of one paradigmatic understanding of how we produce a “conversation” within a given established research methodology. We are then, third, able to consider a number of possible related …

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A Lab To Stemulate Undergraduate Students Into Science, Technology, Engineering And Mathematics Majors, Nicole Lynn Speelman Jan 2009

A Lab To Stemulate Undergraduate Students Into Science, Technology, Engineering And Mathematics Majors, Nicole Lynn Speelman

Browse all Theses and Dissertations

The central focus is the development and implementation of a research/lab module for first year chemistry courses. Electrochemical techniques are utilized to study oxidation and reduction reactions of neurotransmitters with a poly(2,2'-Bithiophene) modified electrode. The goal is to excite students about chemistry and encourage them to continue studies in Science, Technology, Engineering, and Mathematics (STEM) during their undergraduate education. The lab module was created for Project REEL (Research Experiences to Enhance Learning) and will be illustrated with results typically obtained by students. The experiment is inquiry-based, which includes challenging questions students have to do collaboration and research to answer, as …

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Anthropogenic Osmium In Rain And Snow Reveals Global-Scale Atmospheric Contamination, Cynthia Chen, Peter N. Sedwick, Mukul Sharma Jan 2009

Anthropogenic Osmium In Rain And Snow Reveals Global-Scale Atmospheric Contamination, Cynthia Chen, Peter N. Sedwick, Mukul Sharma

OES Faculty Publications

Osmium is one of the rarer elements in seawater, with typical concentration of ≈10 x 10-15 g g-1 ( 5.3 x 10-14 mol kg-1. The osmium isotope composition (187Os/188Os ratio) of deep oceans is 1.05, reflecting a balance between inputs from continental crust (≈ 1.3) and mantle/cosmic dust (≈ 0.13). Here, we show that the 187Os/188Os ratios measured in rain and snow collected around the world range from 0.16 to 0.48, much lower than expected (>1), but similar to the isotope composition of ores (approximate to 0.2) …

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Membrane Properties Of Intact Rock Cores Of Burlington Limestone, Jefferson Dolomite, Darrington Phyllite, And Low Permeability Concrete, Megan Hart Jan 2009

Membrane Properties Of Intact Rock Cores Of Burlington Limestone, Jefferson Dolomite, Darrington Phyllite, And Low Permeability Concrete, Megan Hart

Doctoral Dissertations

"A number of laboratory studies have shown that clays exhibit membrane properties. However, little research has been performed on lithologies outside of pure clays. Recently, research focusing on mixed sand and clay membrane properties for engineering applications was performed. Still, literature only suggests the possibilities of membrane properties, osmotic or reverse-osmotic, associated with other naturally occurring 'tight' rock types. Therefore, the objectives of this research was to perform a series of hyperfiltration experiments using actual rock discs of Quarry Ridge Jefferson Dolomite, Darrington Phyllite, Lower Burlington Limestone, and low permeability concrete to determine if tight lithologies can function as membranes"--Abstract, …

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The Effect Of Learning Styles And Attitude On Preservice Elementary Teachers' Conceptual Understanding Of Chemistry And The Nature Of Matter In A Simulation-Based Learning Environment, Mo H. Al-Jaroudi Jan 2009

The Effect Of Learning Styles And Attitude On Preservice Elementary Teachers' Conceptual Understanding Of Chemistry And The Nature Of Matter In A Simulation-Based Learning Environment, Mo H. Al-Jaroudi

Dissertations and Theses @ UNI

This causal-comparative descriptive study investigated the achievement of pre-service elementary teachers taking an introductory physical science course that integrates inquiry-based instruction with computer simulations. The study was intended to explore if pre-service elementary teachers with different attitudes towards science as well as students with different learning styles would benefit differentially. Four research questions including four hypotheses were developed. The first major question consist of four specific hypothesis that addressed preservice elementary teachers' learning styles (Active/Reflective, Sensing/Intuitive, Visual/Verbal, and Sequential/Global) and their conceptual understanding of chemistry and the particulate nature of matter in a science class which use hands-on learning integrated …

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Mole Street Journal, December 2008, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry Dec 2008

Mole Street Journal, December 2008, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry

Mole Street Journal

No abstract provided.

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Mole Street Journal, November 2008, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry Nov 2008

Mole Street Journal, November 2008, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry

Mole Street Journal

No abstract provided.

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Mole Street Journal, October 2008, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry Oct 2008

Mole Street Journal, October 2008, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry

Mole Street Journal

No abstract provided.

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Mole Street Journal, September 2008, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry Sep 2008

Mole Street Journal, September 2008, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry

Mole Street Journal

No abstract provided.

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Mole Street Journal, August 2008, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry Aug 2008

Mole Street Journal, August 2008, University Of Arkansas, Fayetteville. Dept. Of Chemistry And Biochemistry

Mole Street Journal

No abstract provided.

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